506,328 results match your criteria Joint Bone Spine [Journal]


Origin of neck pain and direction of movement influence dynamic cervical joint motion and pressure pain sensitivity.

Clin Biomech (Bristol, Avon) 2018 Dec 5;61:120-128. Epub 2018 Dec 5.

Center for Neuroplasticity and Pain (CNAP), SMI, Department of Health and Science Technology, Faculty of Medicine, Aalborg University, Denmark.

Background: Patients with neck pain normally showed alterations in cervical motion and pressure pain sensitivity. Cervical joints show scattered motions opposite to (anti-directional) the primary motion direction (pro-directional) during dynamic cervical flexion and extension. This study aimed to assess dynamic cervical joint motion and pressure pain sensitivity when pain originated from different cervical muscles which may have clinical relevance in diagnosis of impairments related with neck pain. Read More

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December 2018

A prediction method of speed-dependent walking patterns for healthy individuals.

Gait Posture 2018 Dec 5;68:280-284. Epub 2018 Dec 5.

Federal University of ABC, Neuroscience and Biomedical Engineering Programs, São Bernardo do Campo, São Paulo, Brazil. Electronic address:

Background: Gait speed is one of the main biomechanical determinants of human movement patterns. However, in clinical gait analysis, the effect of gait speed is generally not considered, and people with disabilities are usually compared with able-bodied individuals even though disabled people tend to walk slower.

Research Questions: This study proposes a simple way to predict the gait pattern of healthy individuals at a specific speed. Read More

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December 2018

Kinematics reduction applied to the comparison of highly-pronated, normal and highly-supinated feet during walking.

Gait Posture 2018 Dec 6;68:269-273. Epub 2018 Dec 6.

Departamento de Ingeniería Mecánica y Construcción, Universitat Jaume I, Av. Vicent Sos Baynat, s/n, 12071, Castellón, Spain. Electronic address:

Background: Kinematic analysis could help to study how variations in the static foot posture affect lower limb biomechanical function. The analysis of foot kinematics is complex because it involves managing the time-dependent joint angles in different joints and in all three planes of motion. But it could be simplified if joint angles are coordinated. Read More

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December 2018

The protective effect of sophocarpine in osteoarthritis: An in vitro and in vivo study.

Int Immunopharmacol 2018 Dec 11;67:145-151. Epub 2018 Dec 11.

Department of Anesthesiology, The Second Affiliated Hospital of Wen Zhou Medical University, 109, Xueyuanxi Road, 325027 Wenzhou, China. Electronic address:

Background: Osteoarthritis (OA) is a type of degenerative joint disease affecting millions of individuals worldwide. However, there are currently no great inflammatory treatments available for it. Sophocarpine (SPC), one of the key bioactive compounds derived from Sophora flavescens, has shown remarkable anti-inflammatory effects. Read More

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December 2018

Selection and characterization of protective anti-chikungunya virus single domain antibodies.

Mol Immunol 2018 Dec 11;105:190-197. Epub 2018 Dec 11.

US Naval Research Laboratory, Center for Biomolecular Science and Engineering, 4555 Overlook Ave SW, Washington, DC 20375, USA. Electronic address:

Chikungunya virus (CHIKV) is a mosquito-borne alphavirus that causes an arthralgia febrile illness that has affected millions of people on three continents. Previously, neutralizing monoclonal antibodies that have prophylactic and therapeutic activity were found to remove virus in joint tissues, thereby reducing the severity of symptoms in mice and non-human primates. In this study, we sought to develop thermostable small recombinant antibodies against CHIKV for future diagnostic, prophylactic and therapeutic applications. Read More

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December 2018

USP14-mediated IκBα degradation exacerbates NF-κB activation and IL-1β-stimulated chondrocyte dedifferentiation.

Life Sci 2018 Dec 11. Epub 2018 Dec 11.

Rehabilitation Department, the Third Hospital of Xingtai City, Xingtai City, Hebei 054000, China.

Osteoarthritis (OA) is an inflammatory joint disease. USP14, a deubiquitinating enzyme critical for ubiquitin-mediated proteasomal protein degradation, is implicated in inflammation regulation. However, its role and mechanism in OA are poorly understood. Read More

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December 2018

Roles for HB-EGF in Mesenchymal Stromal Cell Proliferation and Differentiation During Skeletal Growth.

J Bone Miner Res 2018 Dec 14. Epub 2018 Dec 14.

Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, China.

HB-EGF, a member of the EGF superfamily, plays important roles in development and tissue regeneration. However, its functions in skeletal stem cells and skeleton development and growth remain poorly understood. Here, we used the Cre/LoxP system to ablate or express HB-EGF in Dermo1+ mesenchymal stromal cells and their progenies, including chondrocytes and osteoblast lineage cells, and bone marrow stromal cells (BMSCs). Read More

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December 2018

Comparison of classical and transgenic genetic sexing strains of Mediterranean fruit fly (Diptera: Tephritidae) for application of the sterile insect technique.

PLoS One 2018 14;13(12):e0208880. Epub 2018 Dec 14.

Insect Pest Control Laboratory, Joint FAO/IAEA Division of Nuclear Techniques in Food and Agriculture, International Atomic Energy Agency, Vienna, Austria.

The development of genetic sexing strains (GSSs) based on classical genetic approaches has revolutionized the application of the sterile insect technique (SIT) against the Mediterranean fruit fly Ceratitis capitata (Wiedemann) (Diptera: Tephritidae). The global use of Mediterranean fruit fly GSS for SIT applications as part of area-wide integrated pest management (AW-IPM) programmes is testimony to their effectiveness. During recent years, transgenic sexing strains (TSSs) have been developed through genetic engineering techniques offering the possibility to produce male-only progeny by introducing female embryonic lethal genes and to increase the efficacy to identify released sterile males by means of the expression of fluorescent transgene markers. Read More

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December 2018

Identification of knee gait waveform pattern alterations in individuals with patellofemoral pain using fast Fourier transform.

PLoS One 2018 14;13(12):e0209015. Epub 2018 Dec 14.

Division of Physical Therapy, College of Health Sciences, University of Kentucky, Lexington, KY, United States of America.

Patellofemoral pain (PFP) is one of the most common overuse injuries of the knee. Previous research has found that individuals with PFP exhibit differences in peak hip kinematics; however, differences in peak knee kinematics, where the pain originates, are difficult to elucidate. To better understand the mechanism behind PFP, we sought to characterize differences in knee gait kinematic waveform patterns in individuals with PFP compared to healthy individuals using fast Fourier transform (FFT). Read More

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December 2018

Dissecting the regulation and function of ATP at the single-cell level.

PLoS Biol 2018 Dec 14;16(12):e3000095. Epub 2018 Dec 14.

Center for Quantitative Biology and Peking-Tsinghua Joint Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China.

Regulation of cellular ATP level is critical for diverse biological processes and may be defective in diseases such as cancer and mitochondrial disorders. While mitochondria play critical roles in ATP level regulation, we still lack a systematic and quantitative picture of how individual mitochondrial-related genes contribute to cellular ATP level and how dysregulated ATP levels may affect downstream cellular processes. Advances in genetically encoded ATP biosensors have provided new opportunities for addressing these issues. Read More

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December 2018

What Is the Prevalence of Cam Deformity After Prophylactic Pinning of the Contralateral Asymptomatic Hip in Unilateral Slipped Capital Femoral Epiphysis? A 10-year Minimum Followup Study.

Clin Orthop Relat Res 2018 Dec 13. Epub 2018 Dec 13.

T. D. Lerch, F. Schmaranzer, S. D. Steppacher, M. Tannast, K. A. Siebenrock, Department of Orthopaedic Surgery, Inselspital, University of Bern, Bern, Switzerland E. N. Novais, Department of Pediatric Orthopedic surgery, Boston Children's Hospital, Boston, MA, USA K. Ziebarth, Department of Pediatric Surgery, Inselspital, University of Bern, Bern, Switzerland.

Background: Prophylactic pinning of the asymptomatic and normal-appearing contralateral hip in patients with unilateral slipped capital femoral epiphysis (SCFE) remains controversial. Understanding the minimal 10-year clinical, functional, and radiographic outcomes of the contralateral asymptomatic hip in unilateral SCFE may be helpful in the decision regarding whether the benefits associated with potentially preventing a SCFE are outweighed by the risk of additional surgery.

Questions/purposes: Among patients with SCFE treated with prophylactic pinning of the asymptomatic and contralateral hip, we sought (1) to determine the complications and reoperations; (2) to evaluate the development of cam deformities and the frequency and severity of osteoarthritis progression; and (3) to characterize hip pain and function as measured by the Harris hip score (HHS) and the Hip Disability and Osteoarthritis Outcome Score (HOOS) at minimal 10-year followup. Read More

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December 2018

Replication of newly proposed TNM staging system for medullary thyroid carcinoma: a nationwide study.

Endocr Connect 2018 Dec 1. Epub 2018 Dec 1.

C Godballe, Department of ORL Head and Neck Surgery and Audiology, Odense University Hospital, Odense, Denmark.

A recent study proposed new TNM groupings for better survival discrimination among stage groups for medullary thyroid carcinoma (MTC) and validated these groupings in a population-based cohort in the United States. However, it is unknown how well the groupings perform in populations outside the United States. Consequently, we conducted the first population-based study aiming to evaluate if the recently proposed TNM groupings provide better survival discrimination than the current American Joint Committee on Cancer (AJCC) TNM staging system (seventh and eighth edition) in a nationwide MTC cohort outside the United States. Read More

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December 2018

Handshaking promotes deal-making by signaling cooperative intent.

J Pers Soc Psychol 2018 Dec 13. Epub 2018 Dec 13.

Department of Marketing, Harvard Business School.

We examine how a simple handshake-a gesture that often occurs at the outset of social interactions-can influence deal-making. Because handshakes are social rituals, they are imbued with meaning beyond their physical features. We propose that during mixed-motive interactions, a handshake is viewed as a signal of cooperative intent, increasing people's cooperative behavior and affecting deal-making outcomes. Read More

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December 2018

New recommendations for testing indirect effects in mediational models: The need to report and test component paths.

J Pers Soc Psychol 2018 Dec;115(6):929-943

Department of Psychology, University of Colorado.

In light of current concerns with replicability and reporting false-positive effects in psychology, we examine Type I errors and power associated with 2 distinct approaches for the assessment of mediation, namely the component approach (testing individual parameter estimates in the model) and the index approach (testing a single mediational index). We conduct simulations that examine both approaches and show that the most commonly used tests under the index approach risk inflated Type I errors compared with the joint-significance test inspired by the component approach. We argue that the tendency to report only a single mediational index is worrisome for this reason and also because it is often accompanied by a failure to critically examine the individual causal paths underlying the mediational model. Read More

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December 2018

Developmental psychologies in the Roman world: Change and continuity.

Authors:
Jacob L Mackey

Hist Psychol 2018 Dec 13. Epub 2018 Dec 13.

Occidental College.

A common view among ancient historians about Roman attentiveness to children's psychological development needs reconsideration. The view holds that Romans ignored children's cognitive ontogeny, perceiving early childhood as a largely undifferentiated life stage. A separate but related issue is the problematic claim that Roman childhood was entirely a matter of social construction. Read More

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December 2018

F8-IL10: a new potential anti-rheumatic drug evaluated by a PET-guided translational approach.

Mol Pharm 2018 Dec 14. Epub 2018 Dec 14.

Antibody fragment F8- mediated Interleukin 10 (IL10) delivery is a novel treatment for rheumatoid arthritis (RA). F8 binds to the extra-domain-A of fibronectin (ED-A). In this study, in-vivo biodistribution and arthritis targeting of radiolabeled F8-IL10 were investigated in RA patients, followed by further animal studies. Read More

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December 2018

[Olecranon fractures].

Rev Med Suisse 2018 Dec;14(631):2264-2267

Service de chirurgie orthopédique et traumatologique, Département de l'appareil locomoteur, CHUV, 1011 Lausanne.

Olecranon fractures represent 5 % of all adult fractures. Management is most often surgical. Conservative treatment is recommended for non-displaced fractures or patients who would be poor surgical candidates. Read More

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December 2018

[Cartilaginous tumours].

Rev Med Suisse 2018 Dec;14(631):2259-2263

Service d'orthopédie et traumatologie de l'appareil moteur, HUG, 1211 Genève 14.

Cartilaginous tumours are rare and often incidentally discovered on imaging. They can also be responsible for osteoarticular symptoms (pain, joint stiffness, deformity or fracture) and will require a clinical, radiological and a histopathological assessment. Depending on the lesion, the management may consist of observation or a complex surgical procedure that will take place after a multidisciplinary discussion including the radiologist, the pathologist and the orthopaedic surgeon. Read More

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December 2018

Clinical, Epidemiological, and Etiological Changes in Erythema Nodosum.

Isr Med Assoc J 2018 Dec;20(12):770-772

Department of Internal Medicine F, Soroka University Medical Center and Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel.

Background: Erythema nodosum (EN) is the most common type of panniculitis, commonly secondary to infectious diseases.

Objectives: To elucidate the causative factors and the clinical presentation of patients with EN (2004-2014) and to compare their data to those reported in a previous study.

Methods: A retrospective study was conducted of all patients diagnosed with EN who were hospitalized at Soroka University Medical Center (2004-2014). Read More

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December 2018

[Leucocyte esterase as a reliable diagnostic, cost-effective and fast in knee infections].

Acta Ortop Mex 2018 Jul-Aug;32(4):198-202

Dirección de Educación e Investigación en Salud, Hospital de Traumatología. Unidad Médica de Alta Especialidad (UMAE). «Dr. Victorio de la Fuente Narváez», Instituto Mexicano del Seguro Social (IMSS). Ciudad de México. México.

Background: The articular infection represents a challenge due to its complexity and its devastating effect when not treated promptly. We have various diagnostic studies: cultures, ESR, CRP, count of leukocytes, among others but none is specific, it takes more than 30 minutes to complete and require complex infrastructure. In this study we determine the sensitivity and specificity of the leukocyte esterase for detection of an infectious process joint in Mexican population. Read More

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December 2018

The sensitivity of the forest carbon budget shifts across processes along with stand development and climate change.

Ecol Appl 2018 Dec 14. Epub 2018 Dec 14.

National Research Council of Italy, Institute for Agriculture and Forestry Systems, in the Mediterranean (CNR-ISAFOM), 87036, Rende, CS, Italy.

The future trajectory of atmospheric CO concentration depends on the development of the terrestrial carbon sink, which in turn is influenced by forest dynamics under changing environmental conditions. An in-depth understanding of model sensitivities and uncertainties in non steady-state conditions is necessary for reliable and robust projections of forest development and under scenarios of global warming and CO -enrichment. Here, we systematically assessed if a bio-geochemical process-based model (3D-CMCC-CNR), which embeds similarities with many other vegetation models, applied in simulating net primary productivity (NPP) and standing woody biomass (SWB), maintained a consistent sensitivity to its 55 input parameters through time, during forest-ageing and -structuring as well as under climate-change scenarios. Read More

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December 2018

A Self-assembled Unit Comprising 12 Squaraine Dyes Built up from two Star-Shaped Hexasquarainyl-Benzene Molecules.

Chemistry 2018 Dec 14. Epub 2018 Dec 14.

Universitat Wurzburg, Institut fur Organische Chemie, Am Hubland, D-97074, Würzburg, GERMANY.

We describe the aggregate formation and optical properties of a star-shaped hexaarylbenzene with six squaraine chromophores (= hexasquarainyl benzene). Comprehensive concentration-dependent studies in acetone/CHCl3 mixtures reveal a strong propensity to form discrete dimeric aggregates with a high binding constant in excess of 1 E6 M-1. In this context, a large hypsochromic shift of almost 2 700 cm-1 was found in the absorption spectrum, indicating H-type exciton coupling. Read More

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December 2018

Repetition Priming Effects for Famous Faces through Dynamic Causal Modelling of Latency-Corrected Event-Related Brain Potentials.

Eur J Neurosci 2018 Dec 14. Epub 2018 Dec 14.

Department of Physics, Hong Kong Baptist University, Kowloon Tong, Hong Kong.

Repetition priming, that is, the repeated processing of a stimulus, facilitates performance. However, the neural underpinnings of repetition priming for famous faces in terms of effective connectivity is not known. Here we investigated this problem using dynamic causal modelling of latency-corrected event-related brain potentials (RERPs). Read More

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December 2018

Bayesian latent class analysis of ELISA and RT-rPCR diagnostic accuracy for subclinical Renibacterium salmoninarum infection in Atlantic salmon (Salmo salar) broodstock.

J Fish Dis 2018 Dec 14. Epub 2018 Dec 14.

Marine Harvest Canada, Campbell River, British Columbia, Canada.

Renibacterium salmoninarum infection causes bacterial kidney disease (BKD) in salmonid freshwater and saltwater life stages, with potentially severe financial loss for the aquaculture industry. Preventing vertical transmission, from infected broodstock to eggs, is key to disease management. As there is no perfect reference standard for detecting R. Read More

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December 2018

FDG-PET/CT for diagnosis and follow-up of necrotizing (malignant) external otitis.

Laryngoscope 2018 Dec 14. Epub 2018 Dec 14.

Department of Otolaryngology-Head and Neck Surgery, Petach Tikva, Israel.

Objective: Imaging is important for the diagnosis and follow-up of necrotizing external otitis (NEO). The best imaging modality is controversy. To suggest 2-deoxy-2-[fluorine-18] fluoro-D-glucose-positron emission tomography/computed tomography (18F-FDG-PET/CT) as an alternative to technetium-99m and gallium-67 scans for diagnosis and assessment of response to treatment for patients with NEO. Read More

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December 2018

Estimating the global distribution of field size using crowdsourcing.

Glob Chang Biol 2019 Jan 22;25(1):174-186. Epub 2018 Nov 22.

International Institute for Applied Systems Analysis, ESM, Laxenburg, Austria.

There is an increasing evidence that smallholder farms contribute substantially to food production globally, yet spatially explicit data on agricultural field sizes are currently lacking. Automated field size delineation using remote sensing or the estimation of average farm size at subnational level using census data are two approaches that have been used. However, both have limitations, for example, automatic field size delineation using remote sensing has not yet been implemented at a global scale while the spatial resolution is very coarse when using census data. Read More

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January 2019

Climate change impact and adaptation for wheat protein.

Glob Chang Biol 2019 Jan 22;25(1):155-173. Epub 2018 Nov 22.

Institute of Crop Science and Resource Conservation INRES, University of Bonn, Bonn, Germany.

Wheat grain protein concentration is an important determinant of wheat quality for human nutrition that is often overlooked in efforts to improve crop production. We tested and applied a 32-multi-model ensemble to simulate global wheat yield and quality in a changing climate. Potential benefits of elevated atmospheric CO concentration by 2050 on global wheat grain and protein yield are likely to be negated by impacts from rising temperature and changes in rainfall, but with considerable disparities between regions. Read More

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January 2019
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RanGAP-mediated nucleocytoplasmic transport of Prospero regulates neural stem cell lifespan in Drosophila larval central brain.

Aging Cell 2018 Dec 13:e12854. Epub 2018 Dec 13.

Division of Human Reproduction and Developmental Genetics, The Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, China.

By the end of neurogenesis in Drosophila pupal brain neuroblasts (NBs), nuclear Prospero (Pros) triggers cell cycle exit and terminates NB lifespan. Here, we reveal that in larval brain NBs, an intrinsic mechanism facilitates import and export of Pros across the nuclear envelope via a Ran-mediated nucleocytoplasmic transport system. In rangap mutants, the export of Pros from the nucleus to cytoplasm is impaired and the nucleocytoplasmic transport of Pros becomes one-way traffic, causing an early accumulation of Pros in the nuclei of the larval central brain NBs. Read More

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December 2018

A Highly Active Star Decahedron Cu Nanocatalyst for Hydrocarbon Production at Low Overpotentials.

Adv Mater 2018 Dec 14:e1805405. Epub 2018 Dec 14.

Department of Materials Science and Engineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA.

The electrochemical carbon dioxide reduction reaction (CO RR) presents a viable approach to recycle CO gas into low carbon fuels. Thus, the development of highly active catalysts at low overpotential is desired for this reaction. Herein, a high-yield synthesis of unique star decahedron Cu nanoparticles (SD-Cu NPs) electrocatalysts, displaying twin boundaries (TBs) and multiple stacking faults, which lead to low overpotentials for methane (CH ) and high efficiency for ethylene (C H ) production, is reported. Read More

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December 2018

Enhanced Natural Killer Cell Immunotherapy by Rationally Assembling Fc Fragments of Antibodies onto Tumor Membranes.

Adv Mater 2018 Dec 14:e1804395. Epub 2018 Dec 14.

Chinese Academy of Sciences (CAS) Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology (NCNST), 11 Beiyitiao, Zhongguancun, Beijing, 100190, China.

Recent advances in cancer immunotherapy have exploited the efficient potential of natural killer (NK) cells to kill tumor cells through antibody-dependent cell-mediated cytotoxicity (ADCC). However, this therapeutic strategy is seriously limited by tumor antigen heterogeneity since antibodies can only recognize specific antigens. In this work, modified antibodies or their Fc fragments that can target solid tumors without the necessity of specific antigen presentation on tumors are developed. Read More

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December 2018

Evaluation of the efficacy of granulocyte and monocyte adsorption apheresis on skin manifestation and joint symptoms of patients with pustulotic arthro-osteitis.

J Dermatol 2018 Dec 14. Epub 2018 Dec 14.

Department of Dermatology, Tokyo Medical University, Tokyo, Japan.

Pustulotic arthro-osteitis, occasionally complicated with palmoplantar pustulosis, affects patients' activities of daily living. Granulocyte and monocyte adsorption apheresis selectively removes activated granulocytes and monocytes by means of extracorporeal circulation. Although the efficacy of granulocyte and monocyte adsorption apheresis in the treatment of generalized pustular psoriasis has been proved, very few reports have assessed its efficacy in the treatment of palmoplantar pustulosis and pustulotic arthro-osteitis. Read More

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December 2018
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TGMin: An efficient global minimum searching program for free and surface-supported clusters.

J Comput Chem 2018 Dec 14. Epub 2018 Dec 14.

Department of Chemistry and Laboratory of Organic Optoelectronics & Molecular Engineering of the Ministry of Education, Tsinghua University, Beijing 100084, China.

In this article, we introduce an efficient global-minimum structural search program named Tsinghua Global Minimum 2 (TGMin-2), which is the successor of the original TGMin algorithm that was developed in our group in 2011. We have introduced a number of new features and improvements into TGMin-2, including a symmetric structure generation algorithm that can produce good initial seeds for small- and medium-size clusters, the duplicated structure identification algorithm, and the improved structure adaption algorithm that was implemented in the original TGMin code. To predict the simulated photoelectron spectrum (PE spectrum) automatically, we also implemented a standalone program named AutoPES (Auto Photoelectron Spectroscopy), which can be used to simulate PE spectra and compare them with experimental results automatically. Read More

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December 2018

Sublaminar organization of the human subplate: developmental changes in the distribution of neurons, glia, growing axons and extracellular matrix.

J Anat 2018 Dec 13. Epub 2018 Dec 13.

Croatian Institute for Brain Research, School of Medicine, University of Zagreb, Zagreb, Croatia.

The objective of this paper was to collect normative data essential for analyzing the subplate (SP) role in pathogenesis of developmental disorders, characterized by abnormal circuitry, such as hypoxic-ischemic lesions, autism and schizophrenia. The main cytological features of the SP, such as low cell density, early differentiation of neurons and glia, plexiform arrangement of axons and dendrites, presence of synapses and a large amount of extracellular matrix (ECM) distinguish this compartment from the cell-dense cortical plate (CP; towards pia) and large fiber bundles of external axonal strata of fetal white matter (towards ventricle). For SP delineation from these adjacent layers based on combined cytological criteria, we analyzed the sublaminar distribution of different microstructural elements and the associated maturational gradients throughout development, using immunocytochemical and histological techniques on postmortem brain material (Zagreb Neuroembryological Collection). Read More

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December 2018

New treatment method for mucopolysaccharidosis type VI by liver transplantation.

Pediatr Int 2018 Dec 13. Epub 2018 Dec 13.

Department of Clinical Diagnosis, National Center for Child Health and Development, Tokyo.

Background: Mucopolysaccharidosis (MPS) VI is a rare, autosomal recessive congenital metabolic disorder caused by deficient activity of the lysosomal metabolic enzyme, N-acetylgalactosamine 4-sulfatase. Enzyme replacement therapy (ERT) is current therapeutic treatment for MPS VI, while involves limited compliance to the therapy and high costs. This study aimed to develop a new method of treatment by conducting an orthotopic liver transplantation using an animal model of human MPS VI, and to evaluate and examine its effectiveness for treating MPS VI. Read More

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December 2018

Prevalence of temporomandibular disorders and its clinical signs in Chinese students, 1979-2017: a systematic review and meta-analysis.

Oral Dis 2018 Dec 13. Epub 2018 Dec 13.

College of Stomatology, Chongqing Medical University, Chongqing, China.

Objective: This study intends to assess the prevalence of temporomandibular disorders and its clinical signs in Chinese students.

Materials And Methods: Search strategies were performed in 7 electronic databases, and the reference lists from potentially relevant studies were searched manually. Only observational studies that met the eligibility criteria were selected. Read More

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December 2018

A New Era of Cardiac Cell Therapy: Opportunities and Challenges.

Adv Healthc Mater 2018 Dec 13:e1801011. Epub 2018 Dec 13.

Department of Molecular Biomedical Sciences and Comparative Medicine Institute, North Carolina State University, Raleigh, NC, 27607, USA.

Myocardial infarction (MI), caused by coronary heart disease (CHD), remains one of the most common causes of death in the United States. Over the last few decades, scientists have invested considerable resources on the study and development of cell therapies for myocardial regeneration after MI. However, due to a number of limitations, they are not yet readily available for clinical applications. Read More

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December 2018

Re-emergence of genotype I of African swine fever virus in Ivory-Coast.

Transbound Emerg Dis 2018 Dec 12. Epub 2018 Dec 12.

Animal Production and Health Laboratory, Joint FAO/IAEA Division of Nuclear Techniques in Food and Agriculture, Wagramer Strasse 5, P.O. Box 100, A-1400, Vienna, Austria.

In July 2014, an outbreak of severe hemorrhagic disease in a domestic pig population, was reported in San-Pedro, the second seaport city of Ivory-Coast. Animals of all age groups developed clinical signs consistent with African swine fever (ASF). Tissue and serum samples from dead pigs were sent to the laboratory for diagnostic confirmation and molecular characterization based on the partial B646L (p72), the full E183L (p54) gene and the central variable region of the B602L gene. Read More

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December 2018

Direct and indirect effects of climate on richness drive the latitudinal diversity gradient in forest trees.

Ecol Lett 2018 Dec 12. Epub 2018 Dec 12.

ECNU-Alberta Joint Lab for Biodiversity Study, Tiantong National Station for Forest Ecosystem Research, East China Normal University, 200241, Shanghai.

Climate is widely recognised as an important determinant of the latitudinal diversity gradient. However, most existing studies make no distinction between direct and indirect effects of climate, which substantially hinders our understanding of how climate constrains biodiversity globally. Using data from 35 large forest plots, we test hypothesised relationships amongst climate, topography, forest structural attributes (stem abundance, tree size variation and stand basal area) and tree species richness to better understand drivers of latitudinal tree diversity patterns. Read More

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December 2018

Volumetric F-FDG-PET parameters as predictors of locoregional failure in low-risk HPV-related oropharyngeal cancer after definitive chemoradiation therapy.

Head Neck 2018 Dec 12. Epub 2018 Dec 12.

Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan, US.

Background: We sought to investigate the prognostic value of volumetric positron emission tomography (PET) parameters in patients with human papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma (OPSCC) and a ≤10 pack-year smoking history treated with chemoradiation.

Methods: A total of 142 patients were included. Maximum standardized uptake value, metabolic tumor volume, and total lesion glycolysis (TLG) of the primary tumor, involved regional lymph nodes, and total lesion were calculated. Read More

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December 2018

Illumina-based transcriptomic analysis on recalcitrant seeds of Panax notoginseng for the dormancy release during the after-ripening process.

Physiol Plant 2018 Dec 12. Epub 2018 Dec 12.

College of Agronomy & Biotechnology, Yunnan Agricultural University, Kunming, Yunnan, 650201, China.

Panax notoginseng (Burk) F.H. Chen is an economically and medicinally plant of the family Araliacease, seed dormancy is a key factor limiting the extended cultivation of P. Read More

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December 2018

Naproxen attenuates osteoarthritis progression through inhibiting the expression of prostaglandinl-endoperoxide synthase 1.

J Cell Physiol 2018 Dec 12. Epub 2018 Dec 12.

2nd Ward of Burn Department, Linyi People's Hospital, Linyi, Shandong, China.

Objective: This study aims to test the effect of naproxen treatment and the biological target of naproxen for treating osteoarthritis (OA).

Methods: Differentially expressed genes (DEGs) in OA synovial tissues and normal counterparts were analyzed by messenger RNA microarray analysis. R package (weighted gene coexpression network analysis) was used to divide DEGs into several modules and determine the hub genes in each module. Read More

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December 2018

3T chemical shift-encoded MRI: Detection of altered proximal femur marrow adipose tissue composition in glucocorticoid users and validation with magnetic resonance spectroscopy.

J Magn Reson Imaging 2018 Dec 12. Epub 2018 Dec 12.

New York Langone Health, Department of Radiology, New York University School of Medicine, New York, New York, USA.

Background: Osteoporosis (OP) results in weak bone and can ultimately lead to fracture. Drugs such as glucocorticoids can also induce OP (glucocorticoid-induced osteoporosis [GIO]). Bone marrow adipose tissue composition and quantity may play a role in OP pathophysiology, but has not been thoroughly studied in GIO compared to primary OP. Read More

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December 2018

Brain iron deposition in primary insomnia-An in vivo susceptibility-weighted imaging study.

Brain Behav 2018 Dec 11:e01138. Epub 2018 Dec 11.

Department of Neurology, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China.

Background: To study the brain iron deposition and its relationships with cognitive impairment and sleep quality in primary insomnia (PI).

Methods: Thirty-five patients with PI and 35 volunteers underwent MRI scanning using high-resolution susceptibility-weighted imaging sequence. Bilateral anterior cingulate cortices, posterior cingulate cortex, hippocampus, caudate nucleus, globus pallidus, putamen, thalamus, red nucleus, substantia nigra, parietal cortex, and frontal white matter were selected as regions of interest. Read More

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December 2018

Application and preliminary validation of the hip inflammation MRI scoring system (HIMRISS) in spondyloarthritis.

Int J Rheum Dis 2018 Dec 11. Epub 2018 Dec 11.

Department of Clinical Immunology, Xijing Hospital, The Fourth Military Medical University, Xi'an, China.

Aims: Spondyloarthritis (SpA) is an inflammatory rheumatic disease and hip involvement often results in severe deformities and functional impairment. Magnetic resonance imaging (MRI) is a powerful imaging tool for detecting early hip lesions in SpA. The aims of this study are to apply the hip inflammation MRI scoring system (HIMRISS) in SpA patients and to evaluate its reproducibility and validity. Read More

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December 2018

Declining population trends of European mountain birds.

Glob Chang Biol 2018 Dec 11. Epub 2018 Dec 11.

Dachverband Deutscher Avifaunisten (DDA) e.V., Geschäftsstelle, Münster, Germany.

Mountain areas often hold special species communities, and they are high on the list of conservation concern. Global warming and changes in human land use, such as grazing pressure and afforestation, have been suggested to be major threats for biodiversity in the mountain areas, affecting species abundance and causing distribution shifts towards mountaintops. Population shifts towards poles and mountaintops have been documented in several areas, indicating that climate change is one of the key drivers of species' distribution changes. Read More

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December 2018

Early development of the Australia & New Zealand Musculoskeletal (ANZMUSC) Clinical Trials Network.

Intern Med J 2018 Dec 11. Epub 2018 Dec 11.

Sydney School of Public Health, University of Sydney, Sydney, NSW, Australia.

The Australia and New Zealand Musculoskeletal (ANZMUSC) Clinical Trials Network was formed to build capacity and infrastructure for high quality musculoskeletal clinical trials in our region. The purpose of this paper is to describe the steps taken in its formation to help others interested in establishing similar networks. In particular we describe the steps taken to form the collaboration and our progress in achieving our vision and mission. Read More

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December 2018

Neuroinflammation in the central nervous system: Symphony of glial cells.

Glia 2018 Dec 11. Epub 2018 Dec 11.

Institute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China.

Neuroinflammation in the central nervous system (CNS) is an important subject of neuroimmunological research. Emerging evidence suggests that neuroinflammation is a key player in various neurological disorders, including neurodegenerative diseases and CNS injury. Neuroinflammation is a complex and well-orchestrated process by various groups of glial cells in CNS and peripheral immune cells. Read More

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December 2018

TREM2 triggers microglial density and age-related neuronal loss.

Glia 2018 Dec 11. Epub 2018 Dec 11.

Neural Regeneration, Institute of Reconstructive Neurobiology, University Hospital of Bonn, University of Bonn, Bonn, Germany.

The microglial triggering receptor expressed on myeloid cells 2 (TREM2) signals via the activatory membrane adaptor molecule TYROBP. Genetic variants or mutations of TREM2 or TYROBP have been linked to inflammatory neurodegenerative diseases associated with aging. The typical aging process goes along with microglial changes and mild neuronal loss, but the exact contribution of TREM2 is still unclear. Read More

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December 2018

The use of whole blood in US military operations in Iraq, Syria, and Afghanistan since the introduction of low-titer Type O whole blood: feasibility, acceptability, challenges.

Transfusion 2018 Dec 11. Epub 2018 Dec 11.

Armed Service Blood Program, Brooke Army Medical Center, JBSA-Fort Sam Houston, Texas.

Background: Hemorrhage is the leading cause of preventable death in military and civilian traumatic injury. Blood product resuscitation improves survival. Low-titer Type O Whole Blood (LTOWB) was recently re-introduced to the combat theater as a universal resuscitation product for hemorrhagic shock. Read More

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December 2018

Efficacy of Problem-Solving Therapy for Spouses of Men with Prostate Cancer: A Randomized Controlled Trial.

Psychooncology 2018 Dec 11. Epub 2018 Dec 11.

San Diego Moores Cancer Center, University of California.

Objective: Prostate cancer can have a significant negative impact on patients and their spouses. Problem-solving therapy (PST) has been shown to help reduce distress and improve quality of life among cancer and caregiver populations. This study tested the efficacy of PST for spouses of men with prostate cancer. Read More

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December 2018
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