17 results match your criteria Jobelyn

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Effects of Jobelyn on Isoniazid-Induced Seizures, Biomarkers of Oxidative Stress and Glutamate Decarboxylase Activity in Mice.

Basic Clin Neurosci 2018 Nov-Dec;9(6):389-396. Epub 2018 Nov 3.

Department of Pharmacology and Therapeutics, College of Medicine, University of Ibadan, Ibadan, Nigeria.

Introduction: Isoniazid-induced seizure, often described as Status Epilepticus (SE), is an emergency condition characterized by repeated convulsive episodes that responds poorly to the currently available anticonvulsant drugs. The current study aimed at ascertaining the effect of Jobelyn (JB), an African dietary supplement, on seizures, altered oxidative stress, and glutamate decarboxylase activity induced by isoniazid in mice.

Methods: A total of 6 mice received JB (10-50 mg/kg, PO), pyridoxine (300 mg/kg), diazepam (5 mg/kg), or distilled water (10 mL/kg) 30 minutes prior to the induction of SE with injection of isoniazid (300 mg/kg, IP). Read More

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November 2018

Jobelyn Attenuates Oxidative Stress and Improves Memory Performance in Mice Exposed to Anoxic Stress.

Authors:
Osarume Omorogbe

Drug Res (Stuttg) 2019 May 10;69(5):291-296. Epub 2018 Dec 10.

Neuropharmacology Unit, Department of Pharmacology and Therapeutics, University of Ibadan, Ibadan, Nigeria.

Objective: Chronic stress impairs memory by damaging brain cells via induction of oxidative stress. Hence, the use of agents with antioxidant activity is being investigated as potential drugs against chronic stress-induced memory decline. This study evaluated the effect of Jobelyn (JB), a potent antioxidant food supplement on memory deficit induced by anoxic stress in mice and on brain levels of biomarkers of oxidative stress. Read More

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Jobelyn® ameliorates neurological deficits in rats with ischemic stroke through inhibition of release of pro-inflammatory cytokines and NF-κB signaling pathway.

Pathophysiology 2019 Mar 28;26(1):77-88. Epub 2018 Oct 28.

Health Forever Products Ltd., Ikeja, Lagos, Nigeria.

The effects of Jobelyn® (JB) on neurological deficits and biochemical alterations associated with ischemic stroke induced by bilateral common carotid artery occlusion (BCCAO) in rats were investigated in this study. Male Wistar rats were divided into five groups (n = 8): group 1 served as Sham control; group 2, which served as negative control received normal saline while groups 3-5 were given JB (25, 50 and 100 mg/kg, p.o) daily for 28 days. Read More

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Jobelyn suppresses hippocampal neuronal apoptosis and necrosis in experimental alcohol-induced brain stress.

Pathophysiology 2018 Dec 9;25(4):317-325. Epub 2018 May 9.

Department of Anatomy and Cell Biology, Faculty of Basic Medical Sciences, Delta State University, Abraka, Delta State, Nigeria.

Neurodegeneration in the hippocampus is a consequence of alcohol abuse which compromises the survival of the CNS tissue and its self-renewal capacity. So far, conventional drugs have not been clinically satisfactory in ameliorating neurodegeneration, therefore there has been a surge towards exploring the potentials of nutraceuticals since they mediate their action in a multi-mechanism fashion and may have high therapeutic potentials in CNS diseases. This study, therefore, evaluated the effect of Jobelyn® supplementation in ethanol-induced neurodegeneration of the hippocampus. Read More

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December 2018

Jobelyn attenuates inflammatory responses and neurobehavioural deficits associated with complete Freund-adjuvant-induced arthritis in mice.

Biomed Pharmacother 2018 Feb 27;98:585-593. Epub 2017 Dec 27.

Neuropharmacology Unit, Department of Pharmacology and Therapeutics, College of Medicine, University of Ibadan, Nigeria. Electronic address:

Rheumatoid arthritis (RA) is a chronic inflammatory disease that affects the physical and psychosocial wellbeing of the patients and a major cause of work disability. Current drugs for its treatment only provide palliative effect, as cure for the disease still remains elusive. Jobelyn (JB), a potent anti-oxidant and anti-inflammatory dietary supplement obtained from Sorghum bicolor, has been claimed to relieve arthritic pain. Read More

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February 2018

Jobelyn® Supplement Lowered Neuronal Degeneration: Significance of Altered p53 and ɤ-Enolase Protein Expressions in Prefrontal Cortex of Rat Exposed to Ethanol.

Ann Neurosci 2016 Sep 9;23(3):139-148. Epub 2016 Sep 9.

Department of Anatomy and Cell Biology, Faculty of Basic Medical Sciences, Delta State University, Abraka, Delta State, Nigeria.

Background: Alcohol-induced neurodegeneration, a consequence of chronic ethanol exposure, is a neuroadaptation that drives the progression of alcohol use disorder (AUD). Unfortunately, conventional drugs for AUDs do not prevent neurodegeneration as part of their pharmacological repertoire. Multimodal neuroprotective therapeutic agents are hypothesized to have high therapeutic utility in the treatment of central nervous system. Read More

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September 2016

Jobelyn® exhibited anti-inflammatory, antioxidant, and membrane-stabilizing activities in experimental models.

J Basic Clin Physiol Pharmacol 2015 Sep;26(5):501-8

Background: Jobelyn® (JB) is an African sorghum-based food supplement claimed to be efficacious for the treatment of rheumatoid arthritis (RA). Although in vitro studies confirmed its anti-inflammatory property, no study had shown the effect of JB using in vivo animal models of inflammation. Thus, its effects on acute and chronic inflammation in rats were evaluated in this study. Read More

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September 2015

Antioxidant modulation of nevirapine induced hepatotoxicity in rats.

Interdiscip Toxicol 2015 Mar;8(1):8-14

Department of Biochemistry, College of Medicine University of Lagos, PMB 12003, Lagos-Nigeria.

HIV/AIDS related mortality has been dramatically reduced by the advent of antiretroviral therapy (ART). However, ART presents with associated adverse effects. One of such adverse effects is hepatotoxicity observed with nevirapine (NVP) containing ART. Read More

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Pharmacological evaluation of the analgesic and anxiolytic activities of Jobelyn® in mice.

J Basic Clin Physiol Pharmacol 2014 Mar 6. Epub 2014 Mar 6.

Abstract Background: This study presents the results of the pharmacological evaluation of the analgesic and anxiolytic potentials of Jobelyn®, a potent antioxidant African herbal formulation, in mice. The analgesic effect was assessed utilizing acetic acid-induced writhing, tail immersion and formalin-induced paw licking pain models. The anxiolytic activity was evaluated using elevated-plus maze (EPM) and light/dark box. Read More

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Herbal medicines supplied by community pharmacies in Lagos, Nigeria: pharmacists' knowledge.

Pharm Pract (Granada) 2013 Oct 20;11(4):219-27. Epub 2013 Dec 20.

Department of Pharmacology, College of Medicine, University of Lagos . Lagos ( Nigeria ).

Background: The use of herbal medicines is on the increase globally and they are usually supplied in pharmacies as non-prescription medicines. Pharmacists are, therefore, responsible for educating and informing the consumers about rational use of herbal medicines.

Objective: To evaluate the knowledge of pharmacists in Lagos, Nigeria with regards to the herbal medicines they supplied by their pharmacies. Read More

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October 2013

Clinical efficacy of a West African sorghum bicolor-based traditional herbal preparation Jobelyn shows increased hemoglobin and CD4+ T-lymphocyte counts in HIV-positive patients.

J Altern Complement Med 2014 Jan 27;20(1):53-6. Epub 2013 Nov 27.

1 Department of Pathology, 68 Nigerian Army Reference Hospital , Yaba, Lagos, Nigeria .

Objectives: The purpose of this study was to evaluate a traditional herbal preparation, Jobelyn,® for its effects on anemia and CD4+ T-cell counts in human immunodeficiency virus-positive (HIV+) patients in Nigeria.

Design: An open-label pilot study involving 10 confirmed (HIV+) patients who were not receiving antiretroviral therapy (ARVT) was performed, in which the patients consumed Jobelyn for 8 weeks, at a dose of 500 mg twice daily. The pilot study was followed by a controlled trial involving 51 patients, all confirmed HIV+, where the patients with CD4+ T-cell counts below 350 cells/μL were receiving ARVT. Read More

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January 2014

Antidepressant-like property of Jobelyn®, an African unique herbal formulation, in mice.

Drug Res (Stuttg) 2014 Mar 3;64(3):146-50. Epub 2013 Sep 3.

Department of Pharmacology, Osun State University, Osogbo, Nigeria.

Objectives: The purpose of this investigation was to evaluate whether Jobelyn® (JB) possesses anti-depressant-like property in the mouse forced swimming test (FST), tail suspension test (TST) and yohimbine-induced lethality test (YLT) in aggregated mice.

Methods: Mice were given JB (10-100 mg/kg, p.o. Read More

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Effect of Jobelyn® on intruder- and isolation-induced aggressive behavior in mice.

J Basic Clin Physiol Pharmacol 2013 ;24(4):263-9

Background: Aggression is a violent behavior emitted against another organism that may lead to its harm or death and thus is of public health significance, which necessitates the search for agents with anti-aggressive property. This study investigated the effect of Jobelyn® (JB), a unique African polyherbal formulation, on intruder- and isolation-induced aggressive behaviors in mice.

Methods: Male mice that showed aggression after being housed individually with female counterparts for 3 weeks or kept in isolation for 4 weeks were treated orally (p. Read More

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Evaluation of the effect of jobelyn(®) on chemoconvulsants-induced seizure in mice.

Basic Clin Neurosci 2013 ;4(2):125-9

Department of Pharmacology and Therapeutics, University of Ibadan, Nigeria.

Introduction: Epilepsy is a common central nervous system (CNS) disorder characterized by seizures resulting from episodic neuronal discharges. The incidence of toxicity and refractoriness has compromised the clinical efficacy of the drugs currently used for the treatment of convulsions. Thus, there is a need to search for new medicines from plant origin that are readily available and safer for the control of seizures. Read More

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October 2014

Jobelyn® pretreatment ameliorates symptoms of psychosis in experimental models.

J Basic Clin Physiol Pharmacol 2013 ;24(4):331-6

Background: Psychosis is a chronic neurological disorder and it remains a major medical and social problem in most African countries. Individuals with psychotic illness in this region tend to seek help from traditional medical practitioners, who prescribe herbal remedies as alternative forms of treatment for the disease. Jobelyn® (JB) is a commercial polyherbal formulation that has been acclaimed to show beneficial effects in neurological disorders. Read More

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Antioxidant Property of Jobelyn as the Possible Mechanism Underlying its Anti-amnesic Activity in Rodents.

Basic Clin Neurosci 2013 ;4(1):42-9

Department of Pharmacology and Therapeutics, University of Ibadan, Oyo State, Nigeria.

Introduction: Amnesia or loss of memory is the cardinal hallmark of Alzheimer's disease (AD), a progressive neurodegenerative disorder associated with ageing process. Although, AD had been discovered over a century ago, drugs which could cure or halt the progression of the disease are yet to see the light of the day. However, there has been a growing interest in the use of phytomedicines with multipronged mechanisms of action that could target various aspects of the pathologies of AD. Read More

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October 2014

Use of complementary medicine amongst patients on antiretroviral drugs in an HIV treatment centre in Lagos, Nigeria.

Curr Drug Saf 2012 Apr;7(2):120-5

Department of Pharmacology, College of Medicine, University of Lagos, Nigeria.

Traditional herbal remedies have been used to treat many ailments in Nigeria but the safety of herbal remedies has been the major concerns to many people especially when the chemical constituents of the products are not known. This study is therefore designed to evaluate the prevalence of use of complementary drugs with antiretroviral (ARV) therapy and possible treatment outcome of the concurrent utilization of these therapeutic agents. A descriptive cross-sectional survey of 354 HIV patients attending APIN clinics in LUTH using a consecutive sampling technique was used. Read More

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