3,198 results match your criteria Japanese Journal of Ophthalmology [Journal]


Idiopathic third and sixth cranial nerve neuritis.

Jpn J Ophthalmol 2019 Apr 20. Epub 2019 Apr 20.

Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Ilwon-dong, Kangnam-gu, Seoul, South Korea.

Purpose: To present cases with idiopathic third and sixth cranial nerve neuritis.

Study Design: Retrospective observational study METHODS: The results of high resolution pre- and post- cranial nerve magnetic resonance images (MRI) with three-dimensional sequences for visualizing cranial nerves in patients with third, fourth, and sixth cranial nerve palsies who were treated at the Neuro-ophthalmology Department of Samsung Medical Center were reviewed. Patients with cranial nerve enhancement confirmed by experienced radiologists were identified. Read More

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http://link.springer.com/10.1007/s10384-019-00666-7
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http://dx.doi.org/10.1007/s10384-019-00666-7DOI Listing
April 2019
1 Read

Comparison between refractive outcomes between macula-on and macula-off retinal detachments after phaco-vitrectomy.

Jpn J Ophthalmol 2019 Apr 20. Epub 2019 Apr 20.

Department of Ophthalmology, School of Medicine, Pusan National University, Busan, South Korea.

Purpose: To evaluate axial length (AL) measurements and refractive outcomes in vitrectomy combined with cataract operation for rhegmatogenous retinal detachment (RRD) with wholly detached macula.

Study Design: Retrospective, consecutive, comparative, clinical study.

Methods: We reviewed the data of patients treated by vitrectomy combined with cataract operation for RRD. Read More

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http://dx.doi.org/10.1007/s10384-019-00667-6DOI Listing
April 2019
1 Read

Efficacy and safety of intravitreal drug injections using a short 34-gauge needle.

Jpn J Ophthalmol 2019 Apr 6. Epub 2019 Apr 6.

Department of Ophthalmology, Aichi Medical University, 1-1 Yazako-Karimata, Nagakute, 480-1195, Aichi, Japan.

Purpose: To evaluate the efficacy and safety of intravitreal drug injections using a short 34-gauge needle.

Study Design: Retrospective study.

Methods: This study included patients with age-related macular degeneration, diabetic macular edema, or macular edema associated with retinal vein occlusion. Read More

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http://dx.doi.org/10.1007/s10384-019-00663-wDOI Listing
April 2019
1 Read

Stability, safety, and pharmacokinetics of ganciclovir eye drops prepared from ganciclovir for intravenous infusion.

Jpn J Ophthalmol 2019 Apr 2. Epub 2019 Apr 2.

Department of Biomedical Engineering, Faculty of Life and Medical Sciences, Doshisha University, Kyotanabe, 610-0321, Japan.

Purpose: Hospital-prepared topical ganciclovir eye drops made from intravenous infusions are used to treat cytomegalovirus corneal endotheliitis. This study assessed the efficacy of these eye drops.

Study Design: Experimental study design. Read More

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http://dx.doi.org/10.1007/s10384-019-00665-8DOI Listing

Efficacy of N95 amplitude of pattern electroretinogram measured from baseline to N95 trough in the traumatic optic neuropathy.

Jpn J Ophthalmol 2019 Mar 8. Epub 2019 Mar 8.

Department of Ophthalmology, Kim's Eye Hospital, Youngshin-ro 136, Youngdeungpo-gu, Seoul, 07301, Korea.

Purpose: To investigate the utility of selected pattern electroretinogram (PERG) parameters-including N95 amplitude and N95/P50 ratio, and a BL-N95 amplitude-in the analysis of visual function(s) and for predicting changes in retinal ganglion cell structures in traumatic optic neuropathy.

Study Design: A retrospective, observational case series performed at a single center.

Methods: Forty-four eyes from 36 patients diagnosed with optic neuropathy were included. Read More

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http://link.springer.com/10.1007/s10384-019-00664-9
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http://dx.doi.org/10.1007/s10384-019-00664-9DOI Listing
March 2019
6 Reads

Short-term intraocular pressure changes after intravitreal injection of bevacizumab for retinopathy of prematurity.

Jpn J Ophthalmol 2019 Mar 1. Epub 2019 Mar 1.

Department of Ophthalmology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8575, Japan.

Purpose: To evaluate the short-term changes in intraocular pressure (IOP) after intravitreal injection of bevacizumab (IVB) in premature infants with retinopathy of prematurity (ROP).

Study Design: Prospective cohort study.

Methods: Twenty-two eyes of 11 premature infants with ROP were evaluated. Read More

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http://dx.doi.org/10.1007/s10384-019-00661-yDOI Listing

Indocyanine green angiography-guided focal navigated laser photocoagulation for diabetic macular edema.

Jpn J Ophthalmol 2019 Feb 26. Epub 2019 Feb 26.

Department of Ophthalmology and Visual Science, Nagoya City University Graduate School of Medical Sciences, 1-Kawasumi, Mizuho-ku, Nagoya, 467-8601, Japan.

Purpose: To evaluate the efficacy of indocyanine-green angiography (ICGA)-guided navigated focal laser photocoagulation for diabetic macular edema (DME).

Study Design: Prospective, interventional case series.

Methods: Six patients (8 eyes) were enrolled in this study. Read More

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http://dx.doi.org/10.1007/s10384-019-00662-xDOI Listing
February 2019

Flare changes after intravitreal injection of ocriplasmin in symptomatic vitreomacular traction syndrome.

Jpn J Ophthalmol 2019 Feb 25. Epub 2019 Feb 25.

Eye Clinic, Polytechnic University of Marche, Ancona, Italy.

Purpose: To evaluate the changes in anterior chamber flare after a single intravitreal injection of ocriplasmin (125 μg), in patients with symptomatic vitreomacular traction syndrome (VMT).

Study Design: An institutional review board-approved single-center not randomized prospective study.

Methods: Fifteen eyes of fifteen patients (9 women, 6 men) underwent intravitreal injection with ocriplasmin for symptomatic VMT (width of attachment ≤ 1500 μm). Read More

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http://dx.doi.org/10.1007/s10384-019-00660-zDOI Listing
February 2019
2 Reads

Evaluation of deep convolutional neural networks for glaucoma detection.

Jpn J Ophthalmol 2019 Feb 24. Epub 2019 Feb 24.

Department of Ophthalmology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.

Purpose: To investigate the performance of deep convolutional neural networks (DCNNs) for glaucoma discrimination using color fundus images STUDY DESIGN: A retrospective study PATIENTS AND METHODS: To investigate the discriminative ability of 3 DCNNs, we used a total of 3312 images consisting of 369 images from glaucoma-confirmed eyes, 256 images from glaucoma-suspected eyes diagnosed by a glaucoma expert, and 2687 images judged to be nonglaucomatous eyes by a glaucoma expert. We also investigated the effects of image size on the discriminative ability and heatmap analysis to determine which parts of the image contribute to the discrimination. Additionally, we used 465 poor-quality images to investigate the effect of poor image quality on the discriminative ability. Read More

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http://link.springer.com/10.1007/s10384-019-00659-6
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http://dx.doi.org/10.1007/s10384-019-00659-6DOI Listing
February 2019
1 Read

Clinical predictors of survival in metastatic uveal melanoma.

Jpn J Ophthalmol 2019 Mar 22;63(2):197-209. Epub 2019 Feb 22.

Department of Ophthalmology, Bellvitge University Hospital, Feixa Llarga, s/n, 08907, L'Hospitalet de Llobregat, Barcelona, Spain.

Purpose: To determine the clinical factors that influence survival in patients with metastatic uveal melanoma.

Study Design: Single-center, retrospective review of patients' medical records.

Methods: The following data of ninety-nine consecutive patients (49 men, 50 women) with metastatic uveal melanoma were registered: patient demographics; primary tumor characteristics; features of first melanoma-related metastasis; symptoms and patient status at distant disease debut and metastasis treatment. Read More

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http://dx.doi.org/10.1007/s10384-019-00656-9DOI Listing
March 2019
5 Reads

The proteolytic effect of mast cell tryptase to eotaxin-1/CCL11·eotaxin-2/CCL24 and eotaxin-3/CCL26 produced by conjunctival fibroblasts.

Jpn J Ophthalmol 2019 Mar 22;63(2):215-220. Epub 2019 Feb 22.

Department of Ophthalmology, Juntendo University Urayasu Hospital, 2-1-1, Tomioka Urayasu-shi, Chiba, 279-0021, Japan.

Purpose: To investigate the proteolytic effect of mast cell tryptase on eotaxin-1/CCL11, eotaxin-2/CCL24 and eotaxin-3/CCL26 produced by conjunctival fibroblasts.

Study Design: Experimental.

Methods: The production of eotaxin-1, -2 and -3 by conjunctival fibroblasts stimulated both with and without IL-4/IL-13 or/and TGF-β was assessed by ELISA. Read More

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http://dx.doi.org/10.1007/s10384-019-00655-wDOI Listing

Tear-film-oriented diagnosis for dry eye.

Jpn J Ophthalmol 2019 Mar 19;63(2):127-136. Epub 2019 Feb 19.

Department of Optics and Spectroscopy, Faculty of Physics, St. Kliment Ohridski University of Sofia, Sofia, Bulgaria.

Tear-film (TF) stability protects the ocular surface epithelium from desiccation and is ensured via cooperation between the ocular surface components including constituents of the TF and ocular surface epithelium. Thus, when those components are insufficient or impaired, the TF breakup that initiates dry eye occurs. Recently, new, commercially available eye drops have appeared in Japan that enable TF stabilization via targeted supplementation of deficient ocular surface components. Read More

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http://dx.doi.org/10.1007/s10384-018-00645-4DOI Listing
March 2019
2 Reads

Three-dimensional analysis of morphologic changes and visual outcomes in diabetic macular edema.

Jpn J Ophthalmol 2019 Feb 19. Epub 2019 Feb 19.

Department of Ophthalmology, Konkuk University School of Medicine, Konkuk University Medical Center, 120-1 Neungdong-ro, Gwangjin-gu, Seoul, 05030, Republic of Korea.

Purpose: To investigate the association of retinal fluid volume with the visual and anatomic outcomes of patients with diabetic macular edema (DME) after treatment with bevacizumab.

Study Design: Retrospective observational study.

Methods: We retrospectively analyzed 65 eyes of 58 DME patients treated with bevacizumab. Read More

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http://dx.doi.org/10.1007/s10384-019-00657-8DOI Listing
February 2019

Treatment of macular hemorrhage in retinal arterial microaneurysm: anatomic site-oriented therapy.

Jpn J Ophthalmol 2019 Mar 19;63(2):186-196. Epub 2019 Feb 19.

Department of Ophthalmology, Nihon University Hospital, 1-6 Surugadai, Kanda, Chiyodaku, Tokyo, 101-8309, Japan.

Purpose: To investigate the usefulness of anatomic site-oriented therapy for macular hemorrhage secondary to retinal arterial macroaneurysm (RAM).

Study Design: Retrospective observational study, clinical case series METHODS: Twenty-seven consecutive patients (27 eyes) with macular hemorrhage secondary to RAM were classified according to the retinal layer(s) with hemorrhage identified by optical coherence tomography into 4 types and treated differentially. Vitrectomy was conducted for subinternal limiting membrane hemorrhage (SILMH), intravitreal gas injection for subretinal hemorrhage (SRH) or intraretinal hemorrhage (IRH), and vitrectomy and intravitreal air/gas exchange for multilevel hemorrhage (at least 2 among SILMH/SRH/IRH). Read More

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http://dx.doi.org/10.1007/s10384-019-00653-yDOI Listing
March 2019
5 Reads

Effect of topical steroid instillation on central corneal thickness in eyes with bullous keratopathy.

Jpn J Ophthalmol 2019 Feb 19. Epub 2019 Feb 19.

Miyata Eye Hospital, 6-3, Kuraharacho, Miyakonojo, Miyazaki, 885-0051, Japan.

Purpose: To examine the effects of topical steroid instillation on central corneal thickness in eyes with bullous keratopathy (BK).

Study Design: Retrospective case series METHODS: Consecutive patients with BK who did not wish to receive corneal transplantation and were treated with 0.1% betamethasone eyedrops were included. Read More

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http://dx.doi.org/10.1007/s10384-019-00658-7DOI Listing
February 2019
2 Reads

Prediction of corneal curvature radius after pterygium surgery using anterior segment optical coherence tomography.

Jpn J Ophthalmol 2019 Mar 19;63(2):145-150. Epub 2019 Feb 19.

Hayashi Eye Hospital, 4-23-35, Hakataekimae, Hakata-ku, Fukuoka City, Fukuoka, 812-0011, Japan.

Purpose: To investigate the validity of a multiple regression equation to predict postoperative corneal curvature radius (K) in simultaneous cataract and pterygium surgery using preoperative factors, including preoperative K.

Study Design: Retrospective study.

Methods: Seventy eyes of 58 patients who had undergone initial pterygium removal at the Hayashi Eye Hospital between June 2014 and December 2017 were included in this study. Read More

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http://dx.doi.org/10.1007/s10384-019-00654-xDOI Listing
March 2019
1 Read

Descemet stripping automated endothelial keratoplasty performed by trainees.

Jpn J Ophthalmol 2019 Mar 19;63(2):158-164. Epub 2019 Feb 19.

Department of Ophthalmology, Tokyo Dental College, Ichikawa General Hospital, 5-11-13 Sugano, Ichikawa, Chiba, 272-8513, Japan.

Purpose: To assess the surgical outcomes of Descemet stripping automated endothelial keratoplasty (DSAEK) performed by trainees.

Study Design: Retrospective, case control comparative study.

Methods: This study compared cases performed by trainees with those performed by an experienced surgeon. Read More

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http://link.springer.com/10.1007/s10384-019-00652-z
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http://dx.doi.org/10.1007/s10384-019-00652-zDOI Listing
March 2019
5 Reads

Comparison of pretreatment measurements of anterior segment parameters in eyes with acute and chronic primary angle closure.

Jpn J Ophthalmol 2019 Mar 20;63(2):151-157. Epub 2019 Jan 20.

Department of Ophthalmology, Kobe City Eye Hospital, 2-1-8, Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo, 650-0047, Japan.

Purpose: To compare pretreatment anterior segment parameters between eyes with acute primary angle closure (APAC) and chronic primary angle closure (CPAC), and to identify the characteristics of eyes with APAC.

Study Design: Retrospective.

Methods: We measured pretreatment anterior chamber depth (ACD), iris convexity (IC), and pupil diameter in eyes with APAC and CPAC using anterior segment optical coherence tomography. Read More

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http://dx.doi.org/10.1007/s10384-019-00651-0DOI Listing
March 2019
1 Read

Three cases of acute-onset bilateral photophobia.

Jpn J Ophthalmol 2019 Mar 2;63(2):172-180. Epub 2019 Jan 2.

Department of Ophthalmology, Nagoya University Graduate School of Medicine, 65 Tsuruma-cho, Showa-ku, Nagoya, 466-8550, Japan.

Purpose: To report the findings in 3 cases of bilateral negative electroretinograms (ERGs) with acute onset of photophobia.

Study Design: Retrospective case series.

Methods: The medical charts of the 3 patients were reviewed. Read More

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http://dx.doi.org/10.1007/s10384-018-00649-0DOI Listing
March 2019
4 Reads

Reproducibility and reliability of retinal and optic disc measurements obtained with swept-source optical coherence tomography in a healthy population.

Jpn J Ophthalmol 2019 Mar 2;63(2):165-171. Epub 2019 Jan 2.

Ophthalmology Department, Miguel Servet University Hospital, C/ Padre Arrupe, Consultas Externas de Oftalmología, 50009, Zaragoza, Spain.

Purpose: To analyze the reproducibility of macular and peripapillary thickness measurements, and optic nerve morphometric data obtained with Triton Optical coherence tomography (OCT) in a healthy population.

Study Design: Observational cross sectional study.

Material And Methods: A total of 108 eyes underwent evaluation using the Triton Swept Source-OCT. Read More

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http://dx.doi.org/10.1007/s10384-018-00647-2DOI Listing
March 2019
1 Read

Periocular inverted follicular keratosis: a retrospective series over 17 years.

Jpn J Ophthalmol 2019 Mar 2;63(2):210-214. Epub 2019 Jan 2.

Department of Ophthalmology, Rio Hortega University Hospital, Dulzaina St. 2, 47012, Valladolid, Spain.

Purpose: To evaluate the demographic, clinical, and histopathologic characteristics of periocular inverted follicular keratosis (IFK), a very rare lesion with poorly defined characteristics.

Study Design: Retrospective case series.

Methods: We evaluated 11 patients with clinically diagnosed IFK confirmed by histologic analysis. Read More

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http://dx.doi.org/10.1007/s10384-018-00650-7DOI Listing
March 2019
1 Read

Tear film change and ocular symptoms after reading printed book and electronic book: a crossover study.

Jpn J Ophthalmol 2019 Mar 2;63(2):137-144. Epub 2019 Jan 2.

Department of Ophthalmology, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Wanglang Road, Bangkoknoi, Bangkok, 10700, Thailand.

Purpose: To evaluate and compare tear film changes and ocular symptoms after reading an electronic book (e-book) and a printed book.

Study Design: Clinical and experimental.

Methods: Crossover study was conducted in 30 healthy volunteers, some of whom read an e-book and others a printed book for 20 minutes and then switched the following week. Read More

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http://dx.doi.org/10.1007/s10384-018-00648-1DOI Listing
March 2019
2 Reads

Night-vision aid using see-through display for patients with retinitis pigmentosa.

Jpn J Ophthalmol 2019 Mar 2;63(2):181-185. Epub 2019 Jan 2.

Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.

Purpose: From an early stage, retinitis pigmentosa (RP) patients suffer from night blindness which causes nocturnal mobility difficulties. We created a wearable visual aid that uses a high-performance see-through display, and added a high-sensitivity camera with a complementary metal-oxide-semiconductor sensor. Here, we evaluate the device's efficacy for helping night-blindness sufferers walk in the dark. Read More

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http://dx.doi.org/10.1007/s10384-018-00644-5DOI Listing
March 2019
1 Read

Influence of irrigation dynamic pressure-assisted hydrodissection on intraocular pressure and the posterior chamber-anterior hyaloid membrane barrier during cataract surgery.

Jpn J Ophthalmol 2019 Mar 19;63(2):221-228. Epub 2018 Dec 19.

Department of Ophthalmology, School of Medicine, The Jikei University, 3-25-8 Nishishinbashi, Minato-ku, Tokyo, 105-8461, Japan.

Purpose: To evaluate the effects of irrigation dynamic pressure-assisted hydrodissection (irrigation-hydro: iH) on intraocular pressure (IOP) and the posterior chamber-anterior hyaloid membrane (PC-AHM) barrier in porcine eyes.

Study Design: Experimental.

Methods: In Experiment 1, IOP was recorded while irrigating the anterior chamber (AC), during iH, and during phacoemulsification and aspiration in 20 porcine eyes using bottle heights of 50, 70, and 90 cm. Read More

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http://link.springer.com/10.1007/s10384-018-00646-3
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http://dx.doi.org/10.1007/s10384-018-00646-3DOI Listing
March 2019
43 Reads

In vivo histology and p.L132V mutation in KRT12 gene in Japanese patients with Meesmann corneal dystrophy.

Jpn J Ophthalmol 2019 Jan 7;63(1):46-55. Epub 2018 Dec 7.

Department of Ophthalmology, Kanazawa University Graduate School of Medical Science, 13-1 Takara-machi, Kanazawa, Ishikawa, 920-8641, Japan.

Purpose: To report genetic mutational analysis and in vivo histology of Meesmann corneal dystrophy.

Study Design: Prospective, case control study.

Methods: Six patients from three independent families with clinically diagnosed Meesmann corneal dystrophy were enrolled in this study. Read More

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http://dx.doi.org/10.1007/s10384-018-00643-6DOI Listing
January 2019
4 Reads

Correlation between macular structure and function in patients with age-related macular degeneration treated with intravitreal ranibizumab: 12-month-results.

Jpn J Ophthalmol 2019 Jan 23;63(1):90-99. Epub 2018 Nov 23.

Department of Ophthalmology, Dokkyo Medical University Saitama Medical Center, 2-1-50 Minami-Koshigaya, Koshigaya, Saitama, 343-8555, Japan.

Purpose: To determine the significance of the correlation between optical coherence tomographic (OCT) findings and focal macular electroretinograms (fmERG) at 12 months after beginning intravitreal injections of ranibizumab (IVR) in eyes with age-related macular degeneration (AMD).

Study Design: Prospective, clinical study.

Method: We studied 28 eyes of 28 patients with AMD treated with IVR at monthly intervals for the initial three months. Read More

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http://dx.doi.org/10.1007/s10384-018-0642-1DOI Listing
January 2019
14 Reads

The impact of disc hemorrhage studies on our understanding of glaucoma: a systematic review 50 years after the rediscovery of disc hemorrhage.

Authors:
Tetsuya Yamamoto

Jpn J Ophthalmol 2019 Jan 21;63(1):7-25. Epub 2018 Nov 21.

Department of Ophthalmology, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu-shi, 501-1194, Japan.

Purpose Of Review: To trace the influence of disc hemorrhage studies on our understanding of glaucoma.

Sources: Major articles published during the last 50 years since the rediscovery of disc hemorrhage were identified. A total of 196 articles were selected from 435 articles retrieved using the keywords glaucoma and disc hemorrhage as of August 9 2018 from PubMed. Read More

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http://dx.doi.org/10.1007/s10384-018-0641-2DOI Listing
January 2019
1 Read

Uveitis: contrasting the approaches in Japan and the United States.

Jpn J Ophthalmol 2019 Jan 20;63(1):1-6. Epub 2018 Nov 20.

Casey Eye Institute, Oregon Health and Sciences University, 3375 SW, Terwilliger Blvd, Portland, OR, 97239, USA.

Purpose: To compare the approaches to uveitis in Japan and the United States.

Methods: This report is based on the author's personal experience, conversations with Japanese colleagues, and a literature search using the database of the US National Library of Medicine.

Results: The frequencies of specific forms of uveitis vary between the two countries. Read More

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http://dx.doi.org/10.1007/s10384-018-0633-2DOI Listing
January 2019
13 Reads

Current status of late and recurrent intraocular lens dislocation: analysis of real-world data in Japan.

Jpn J Ophthalmol 2019 Jan 13;63(1):65-72. Epub 2018 Nov 13.

Department of Pharmacoepidemiology, Graduate School of Medicine and Public Health, Kyoto University, Yoshidakonoe-cho, Sakyo-ku, Kyoto, 606-8501, Japan.

Purpose: To describe relevant patient demographic characteristics and investigate the influence of known risk factors for late intraocular lens (IOL) dislocation. To explore the associations between these risk factors and the incidence of recurrent IOL dislocation.

Study Design: Retrospective cohort study. Read More

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http://link.springer.com/10.1007/s10384-018-0637-y
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http://dx.doi.org/10.1007/s10384-018-0637-yDOI Listing
January 2019
8 Reads

Prognosis after lamellar keratoplasty for limbal dermoids using preserved corneas.

Jpn J Ophthalmol 2019 Jan 12;63(1):56-64. Epub 2018 Nov 12.

Department of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.

Purpose: To evaluate the safety and efficacy of lamellar keratoplasty using preserved donor corneas to treat limbal dermoids.

Study Design: Retrospective study.

Methods: The clinical records of 19 patients with limbal dermoids, who underwent lamellar keratoplasty using preserved corneas that were observed for more than 6 months at the Keio University School of Medicine between January, 2000 and December, 2017, were retrospectively reviewed. Read More

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http://link.springer.com/10.1007/s10384-018-0639-9
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http://dx.doi.org/10.1007/s10384-018-0639-9DOI Listing
January 2019
26 Reads

Establishment of a normative database and evaluation of the test-retest repeatability of the Spaeth/Richman contrast sensitivity test.

Jpn J Ophthalmol 2019 Jan 10;63(1):73-81. Epub 2018 Nov 10.

Glaucoma Research Center, Wills Eye Hospital, Philadelphia, PA, 19107, USA.

Purpose: To evaluate the test-retest repeatability of a computer-based contrast sensitivity (CS) test, the Spaeth/Richman contrast sensitivity (SPARCS) test, and to determine the effects of age and lens status on CS in normal eyes.

Study Design: Prospective cross-sectional study.

Methods: The participants were assessed by use of the SPARCS test in each eye 3 times. Read More

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http://link.springer.com/10.1007/s10384-018-0640-3
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http://dx.doi.org/10.1007/s10384-018-0640-3DOI Listing
January 2019
19 Reads

Clinical characteristics and outcomes of open globe injuries in Japan.

Jpn J Ophthalmol 2019 Jan 8;63(1):109-118. Epub 2018 Nov 8.

Department of Ophthalmology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, Ibaraki, 305-8575, Japan.

Purpose: To describe the epidemiology and clinical outcomes of open globe injuries (OGIs) in Japan over 10 years, and examine preoperative factors influencing the visual prognosis after surgery.

Study Design: Retrospective, observational, multicenter case-series study.

Methods: Patients' data were entered into a computerized database for review and statistical analyses. Read More

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http://link.springer.com/10.1007/s10384-018-0638-x
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http://dx.doi.org/10.1007/s10384-018-0638-xDOI Listing
January 2019
17 Reads

The 24-month outcomes of intravitreal aflibercept combined with photodynamic therapy for polypoidal choroidal vasculopathy.

Jpn J Ophthalmol 2019 Jan 7;63(1):100-108. Epub 2018 Nov 7.

Division of Ophthalmology, Department of Surgery, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan.

Purpose: This study was prospectively carried out to clarify the effectiveness of visual and anatomical outcomes under combination therapy of intravitreal aflibercept (IVA) and verteporfin photodynamic therapy (vPDT) in over 24 months.

Study Design: A single-arm prospective exploratory study.

Methods: Twenty-six eyes of 26 treatment naïve PCV patients were enrolled in this study. Read More

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http://link.springer.com/10.1007/s10384-018-0636-z
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http://dx.doi.org/10.1007/s10384-018-0636-zDOI Listing
January 2019
7 Reads

Scientific Reviewers.

Authors:

Jpn J Ophthalmol 2018 Nov;62(6):706-707

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http://dx.doi.org/10.1007/s10384-018-0627-0DOI Listing
November 2018
1 Read

Management of presumed trematode induced granulomatous uveitis in pediatric patients.

Jpn J Ophthalmol 2019 Jan 2;63(1):119-125. Epub 2018 Nov 2.

Pathology Department, Faculty of Medicine, Sohag University, Sohâg, Egypt.

Purpose: To outline the management of newly identified trematode induced uveitis in pediatric patients STUDY DESIGN: Prospective interventional case series METHODS: Patients with distinctive uveitis were recruited to either receive steroid monotherapy or undergo surgical excision of the inflammatory lesions based on a scoring system. Outcome measures included best corrected visual acuity (BCVA), intraocular inflammatory activity, and incidence of ophthalmic complications RESULTS: 170 patients (174 eyes) were recruited. Mean age was 11. Read More

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http://link.springer.com/10.1007/s10384-018-0632-3
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http://dx.doi.org/10.1007/s10384-018-0632-3DOI Listing
January 2019
12 Reads
1.800 Impact Factor

Additive intraocular pressure-lowering effects of the Rho kinase inhibitor ripasudil in Japanese patients with various subtypes of glaucoma.

Jpn J Ophthalmol 2019 Jan 28;63(1):40-45. Epub 2018 Oct 28.

Department of Ophthalmology, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo, 113-8655, Japan.

Purpose: The present study aimed to investigate the effectiveness of adjunctive therapy involving the Rho-associated, coiled-coil-containing protein kinase (ROCK) inhibitor ripasudil in lowering intraocular pressure (IOP) in patients with different subtypes of glaucoma, on the basis of the time of IOP measurement STUDY DESIGN: Retrospective study METHODS: In total, 58 patients who underwent adjunctive therapy with ripasudil at a single institution were included. They were classified into a primary open-angle glaucoma (POAG) group, an exfoliation glaucoma (XFG) group, and a secondary glaucoma associated with uveitis, or steroid glaucoma (SG), group. The average IOPs within 6 months before (pre-IOP) and after (post-IOP) the addition of ripasudil were compared among the 3 groups. Read More

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http://link.springer.com/10.1007/s10384-018-0635-0
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January 2019
28 Reads

Clinical features of superior segmental optic hypoplasia: hospital-based study.

Jpn J Ophthalmol 2019 Jan 26;63(1):34-39. Epub 2018 Oct 26.

Department of Ophthalmology, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu-shi, 501-1194, Japan.

Purpose: To determine the clinical features of patients diagnosed with superior segmental optic hypoplasia (SSOH) and to quantitatively compare retinal nerve fiber layer (RNFL) thickness in SSOH eyes, to that in normal subjects.

Study Design: Retrospective comparative case series.

Methods: We examined the medical charts of 106 eyes of 59 patients with SSOH and 35 eyes of 35 normal subjects as controls. Read More

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http://link.springer.com/10.1007/s10384-018-0634-1
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January 2019
25 Reads

Kago-Eye2 software for semi-automated segmentation of subfoveal choroid of optical coherence tomographic images.

Jpn J Ophthalmol 2019 Jan 24;63(1):82-89. Epub 2018 Oct 24.

Department of Ophthalmology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.

Purpose: To determine the capabilities of the "Kago-Eye2" software to semi-automatically segment the choroid in the optical coherence tomographic (OCT) images.

Study Design: A cross-sectional, prospective study of 44 healthy volunteers.

Methods: The Kago-eye2 software was developed to detect the border between Choriocapillaris and Sattler's layer (C-S) and between Sattler's layer and Haller's layer (S-H). Read More

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http://link.springer.com/10.1007/s10384-018-0631-4
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January 2019
4 Reads

Posterior subtenon infusion of triamcinolone acetonide as adjunctive treatment to panretinal photocoagulation using pattern scan laser for diabetic retinopathy.

Jpn J Ophthalmol 2018 Nov 17;62(6):686-692. Epub 2018 Oct 17.

Department of Ophthalmology, Faculty of Medical Sciences, University of Fukui, Eiheiji-cho, Yoshida-gun, Fukui, Fukui-ken, 910-1193, Japan.

Purpose: To estimate the effect of sub-Tenon's capsule triamcinolone acetonide injection (STTA) combined with panretinal photocoagulation (PRP) using pattern scan laser (PSL) for high risk non-proliferative diabetic retinopathy (NPDR), in terms of the inflammation and the progression of diabetic macular edema (DME).

Study Design: Retrospective comparative analysis.

Methods: NPDR patients who underwent PRP using PSL with (STTA+PSL group, n=24) or without (PSL group, n=19) pretreatment of STTA were enrolled. Read More

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http://link.springer.com/10.1007/s10384-018-0628-z
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November 2018
5 Reads

Comparison of recurrent esotropia and consecutive exotropia with horizontal muscle reoperation in infantile esotropia.

Jpn J Ophthalmol 2018 Nov 17;62(6):693-698. Epub 2018 Oct 17.

Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Irwon-Ro 81, Gangnam-gu, Seoul, Republic of Korea.

Purpose: We investigated the clinical and demographic factors associated with horizontal muscle reoperation due to recurrent esotropia or consecutive exotropia in infantile esotropia.

Methods: One hundred forty-two patients with infantile esotropia who received at least 3 years of follow-up after their first surgery between January 2004 and December 2012 were included in this study. The patients were divided into 2 groups according to the reoperation, and the reoperation group was further subdivided into 2 groups [recurrent esotropia (RET) and consecutive exotropia (CXT)]. Read More

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November 2018
1 Read

Genetic diversity and persistent colonization of Enterococcus faecalis on ocular surfaces.

Jpn J Ophthalmol 2018 Nov 15;62(6):699-705. Epub 2018 Oct 15.

Department of Ophthalmology, Gunma University Graduate School of Medicine, 3-39-15 Showa-machi, Maebashi, Gunma, 371-8511, Japan.

Purpose: Enterococcus faecalis causes severe acute endophthalmitis and often leads to poor visual outcomes. Conjunctival bacterial cultures occasionally grow atypical bacteria including E. faecalis, which can potentially contribute to the development of postoperative endophthalmitis. Read More

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http://link.springer.com/10.1007/s10384-018-0630-5
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November 2018
28 Reads

Automated segmentation of en face choroidal images obtained by optical coherent tomography by machine learning.

Jpn J Ophthalmol 2018 Nov 6;62(6):643-651. Epub 2018 Oct 6.

Department of Ophthalmology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.

Purpose: To develop an automated method to segment the choroidal layers of en face optical coherent tomography (OCT) images by machine learning.

Study Design: A cross-sectional, prospective study of 276 eyes of 181 healthy subjects.

Methods: OCT en face images of the choroid were obtained every 2. Read More

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http://link.springer.com/10.1007/s10384-018-0625-2
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November 2018
4 Reads

Intraocular pressure and wound state immediately after long versus short clear corneal incision cataract surgery.

Jpn J Ophthalmol 2018 Nov 6;62(6):621-627. Epub 2018 Oct 6.

Hayashi Eye Hospital, 4-23-35 Hakataekimae, Hakata-ku, Fukuoka, 812-0011, Japan.

Purpose: To compare the intraocular pressure (IOP) and wound state immediately after cataract surgery for eyes with a long clear corneal incision (CCI) with those for eyes with a short CCI.

Study Design: Randomized clinical trial.

Methods: One hundred twenty-eight eyes of 128 patients scheduled for phacoemulsification were randomly assigned to undergo long (≥ 1. Read More

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http://link.springer.com/10.1007/s10384-018-0626-1
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November 2018
17 Reads

Bevacizumab dosing every 2 weeks for neovascular age-related macular degeneration refractory to monthly dosing.

Jpn J Ophthalmol 2018 Nov 29;62(6):652-658. Epub 2018 Sep 29.

Department of Ophthalmology, Meir Medical Center, Kfar Sava and the Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.

Purpose: To evaluate intravitreal bevacizumab every 2 weeks (biweekly) in refractory neovascular age-related macular degeneration (nAMD).

Study Design: Retrospective study.

Methods: A retrospective study of consecutive nAMD patients unresponsive to monthly intravitreal anti-vascular endothelial growth factor (VEGF) switched to 3-4 biweekly injections. Read More

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http://link.springer.com/10.1007/s10384-018-0619-0
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November 2018
6 Reads

Incidence and causes of visual impairment in Japan: the first nation-wide complete enumeration survey of newly certified visually impaired individuals.

Jpn J Ophthalmol 2019 Jan 25;63(1):26-33. Epub 2018 Sep 25.

Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho Kita-ku, Okayama, Okayama, 700-8558, Japan.

Purpose: To investigate the visual impairment certification status in Japan.

Study Design: Observational cross-sectional study.

Methods: We asked all welfare offices throughout Japan to submit data concerning age, sex, causative diseases, and visual impairment grades for newly certified visually impaired individuals aged ≥ 18 years in the fiscal year of 2015. Read More

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http://link.springer.com/10.1007/s10384-018-0623-4
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January 2019
23 Reads

Topical non-steroidal anti-inflammatory drugs for the treatment of cystoid macular edema post Descemet's stripping automated endothelial keratoplasty.

Jpn J Ophthalmol 2018 Nov 25;62(6):615-620. Epub 2018 Sep 25.

Department of Frontier Medical Science and Technology for Ophthalmology, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Hirokoji-agaru, Kawaramachi-dori, Kamigyo-ku, Kyoto, 602-0841, Japan.

Purpose: To investigate the effectiveness of topical non-steroidal anti-inflammatory drugs (NSAIDs) in the treatment of cystoid macular edema (CME) post Descemet's stripping automated endothelial keratoplasty (DSAEK).

Study Design: Retrospective observational study METHODS: In this study of 334 patients who underwent DSAEK at the Baptist Eye Institute, Kyoto, Japan between July 2011 and December 2015, 18 patients with postoperative CME (determined by optical coherence tomography) treated with topical NSAIDs after the onset of CME were included.

Results: At CME onset, 17 of the 18 patients were treated with bromfenac eye drops and 1 was treated with nepafenac eye drops. Read More

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http://dx.doi.org/10.1007/s10384-018-0621-6DOI Listing
November 2018
9 Reads

Occurrence of Demodex species in patients with blepharitis and in healthy individuals: a 10-year observational study.

Jpn J Ophthalmol 2018 Nov 25;62(6):628-633. Epub 2018 Sep 25.

Department of Microbiology, Wroclaw Medical University, Chalubinskiego Street 4, 50-368, Wrocław, Poland.

Purpose: Two Demodex species (eyelash mites)-D. folliculorum and D brevis-are believed to be associated with human skin and eye diseases. However, the clinical significance of infection with Demodex species remains controversial. Read More

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http://link.springer.com/10.1007/s10384-018-0624-3
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November 2018
6 Reads

Contribution of the clock gene DEC2 to VEGF mRNA upregulation by modulation of HIF1α protein levels in hypoxic MIO-M1 cells, a human cell line of retinal glial (Müller) cells.

Jpn J Ophthalmol 2018 Nov 24;62(6):677-685. Epub 2018 Sep 24.

Department of Ophthalmology, Faculty of Medicine, Oita University, 1-1 Yufu-shi, Oita, 879-5593, Japan.

Purpose: Clock genes are components of the molecular clock. Their malfunction is thought to increase the risk of numerous diseases, including cancer. Vascular endothelial growth factor (VEGF) has a pivotal role in angiogenesis, and its expression levels are controlled by clock genes in tumor cells. Read More

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http://link.springer.com/10.1007/s10384-018-0622-5
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November 2018
7 Reads

Three dimensional neuro-retinal rim thickness and retinal nerve fiber layer thickness using high-definition optical coherence tomography for open-angle glaucoma.

Jpn J Ophthalmol 2018 Nov 18;62(6):634-642. Epub 2018 Sep 18.

Department of Ophthalmology, Seoul National University Hospital, 101, Daehak-Ro Jongno-Gu, Seoul, 03080, Republic of Korea.

Purpose: To compare the diagnostic capability of three-dimensional (3D) neuro-retinal rim thickness (NRR) with existing optic nerve head and retinal nerve fiber layer (RNFL) scan parameters using high-definition optical coherence tomography (HD-OCT).

Design: Retrospective study.

Methods: Based on the mean deviation (MD) of the Humphrey Field Analyzer (HFA), the 152 subjects were categorized into mild (MD > - 6 dB, 100), moderate (MD - 6 to - 12 dB, 26), and severe (MD < - 12 dB, 26) glaucoma. Read More

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http://link.springer.com/10.1007/s10384-018-0620-7
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November 2018
5 Reads

Infection of endotheliotropic human cytomegalovirus of trabecular meshwork cells.

Jpn J Ophthalmol 2018 Nov 6;62(6):667-676. Epub 2018 Sep 6.

Department of Ophthalmology and Visual Science, Tottori University Faculty of Medicine, 36-1 Nishicho, Yonago, 683-8504, Japan.

Purpose: Human cytomegalovirus (HCMV) infections can cause endotheliitis which is associated with an elevation in the intraocular pressure (IOP). However, the mechanism of the IOP elevation has not been established. The purpose of this study was to determine whether HCMV strains which are capable of infecting corneal endothelial cells can also replicate and induce anti-viral responses, and can reorganize the actin cytoskeleton in trabecular meshwork cells. Read More

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http://link.springer.com/10.1007/s10384-018-0618-1
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November 2018
4 Reads