4,678 results match your criteria Japanese Journal of Clinical Oncology [Journal]


Treatment status and safety of crizotinib in 2028 Japanese patients with ALK-positive NSCLC in clinical settings.

Jpn J Clin Oncol 2019 Apr 22. Epub 2019 Apr 22.

Graduate School of Medicine, Nippon Medical School, 1-1-5, Sendagi, Bunkyo-ku, Tokyo, Japan.

Objective: Post-marketing surveillance (PMS) was performed in Japan to obtain information on the safety and efficacy of crizotinib.

Methods: Target patients included almost all patients with anaplastic lymphoma kinase-positive non-small cell lung cancer who were administered crizotinib. The observation period was 52 weeks. Read More

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http://dx.doi.org/10.1093/jjco/hyz049DOI Listing

Perinephric invasion as a prognostic factor in non-metastatic renal cell carcinoma: analysis of a nation-wide registry program.

Jpn J Clin Oncol 2019 Apr 12. Epub 2019 Apr 12.

The Cancer Registration Committee of the Japanese Urological Association, Japan.

Objectives: Perinephric fat invasion (PFI) of renal cell carcinoma (RCC) is known to be associated with adverse pathological features and poor prognosis. We analyzed these associations using a sub-group of the RCC registry of The Cancer Registration Committee of the Japanese Urological Association.

Methods: The study cohort of 2998 non-metastatic cases was retrieved from RCC registry (3648 in total). Read More

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http://dx.doi.org/10.1093/jjco/hyz054DOI Listing
April 2019
1 Read
1.747 Impact Factor

Effects of adjuvant radiation therapy on survival for patients with resected primary tracheal carcinoma: an analysis of the National Cancer Database.

Jpn J Clin Oncol 2019 Apr 12. Epub 2019 Apr 12.

Department of Radiation Oncology, University of Louisville Hospital, Louisville KY, USA.

Objective(s): To identify predictors for receiving adjuvant radiation therapy (RT) and investigate the impact of adjuvant RT on survival for patients with resected primary tracheal carcinoma (PTC).

Methods: The National Cancer database was queried for patients with PTC diagnosed from 2004 to 2014 undergoing resection. Patients who died within 30 days of resection were excluded to minimize immortal time bias. Read More

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http://dx.doi.org/10.1093/jjco/hyz047DOI Listing
April 2019
37 Reads

Effects of TACE and preventive antiviral therapy on HBV reactivation and subsequent hepatitis in hepatocellular carcinoma: a meta-analysis.

Jpn J Clin Oncol 2019 Apr 10. Epub 2019 Apr 10.

Department of Gastroenterology, Affiliated Hospital of Nantong University, Jiangsu, China.

Background And Aim: The impact of transarterial chemoembolization (TACE) and preventive antiviral therapy on the occurrence of hepatitis B virus (HBV) reactivation and subsequent hepatitis remains controversial. This meta-analysis aimed to evaluate the effect of TACE and preventive antiviral therapy on the risk of HBV reactivation and subsequent hepatitis. Meanwhile, we explored the role of HBeAg status in HBV reactivation after TACE. Read More

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http://dx.doi.org/10.1093/jjco/hyz046DOI Listing

Early detection of bone metastases of hepatocellular carcinoma reduces bone fracture and paralysis.

Jpn J Clin Oncol 2019 Apr 8. Epub 2019 Apr 8.

Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo.

Background: With the improvement in survival of hepatocellular carcinoma patients, extrahepatic metastases have become a more frequent complication. Although pathological fractures or paralysis due to bone metastases deteriorate the quality of life of patients, no treatment guideline for bone metastases has been established. This study aimed to clarify the risk factors for these events and the clinical course of patients with bone metastases. Read More

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http://dx.doi.org/10.1093/jjco/hyz028DOI Listing

Incidence rates of brain and central nervous system malignancy in the world from the Cancer Incidence in Five Continents XI.

Jpn J Clin Oncol 2019 Apr 3. Epub 2019 Apr 3.

Division of Medical Support and Partnership, Center for Cancer Control and Information Services, National Cancer Center, Tokyo, Japan.

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http://dx.doi.org/10.1093/jjco/hyz055DOI Listing
April 2019
1 Read

Nivolumab versus everolimus in advanced renal cell carcinoma: Japanese subgroup 3-year follow-up analysis from the Phase III CheckMate 025 study.

Jpn J Clin Oncol 2019 Apr 3. Epub 2019 Apr 3.

Department of Urology, Kindai University Faculty of Medicine, Osaka, Japan.

Background: Nivolumab treatment resulted in superior efficacy and safety versus everolimus treatment in the 2-year follow-up of the CheckMate 025 Phase III study, with consistent results in the global population and the Japanese population. Here, we report the 3-year follow-up in both groups.

Methods: Patients were randomized 1:1 to nivolumab 3 mg/kg intravenously every 2 weeks or everolimus 10 mg orally once daily until progression/intolerable toxicity. Read More

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http://dx.doi.org/10.1093/jjco/hyz026DOI Listing
April 2019
4 Reads
1.747 Impact Factor

How to optimize the therapeutic effect of free autogenous fibula graft and wrist arthroplasty for giant cell tumors of distal radius?

Jpn J Clin Oncol 2019 Apr 3. Epub 2019 Apr 3.

Department of Orthopeadics, Xiangya Hospital, Central South University, Changsha, China.

Objective: The purpose of this study is to retrospectively analyze the clinical efficacy of free fibula autograft and wrist arthroplasty in the treatment of giant cell tumors (GCT) of distal radius.

Methods: We retrospectively reviewed 26 patients with GCT of distal radius who underwent free autogenous fibula graft and wrist arthroplasty for repairing residual defect after en-block resection. The length of the fibula graft was 8. Read More

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http://dx.doi.org/10.1093/jjco/hyz045DOI Listing
April 2019
1 Read

The prognostic signature of the somatic mutations in Ewing sarcoma: from a network view.

Jpn J Clin Oncol 2019 Mar 30. Epub 2019 Mar 30.

Spine Center, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai.

Background: Ewing sarcoma is a malignant bone tumor mainly affecting teenagers and young adults. Its main driver mutation, the EWS-FLI1 fusion gene, has been identified more than 20 years ago, whereas its other somatic mutations have been just recently reported.

Methods: In this study, we organized the somatic mutations from 216 Ewing sarcoma cases into 216 individual protein-protein interaction networks by using interactome information. Read More

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http://dx.doi.org/10.1093/jjco/hyz037DOI Listing
March 2019
1 Read

Development and validation of nomograms for prediction of overall survival and cancer-specific survival of patients with Stage IV colorectal cancer.

Jpn J Clin Oncol 2019 Mar 29. Epub 2019 Mar 29.

Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai, P.R. China.

Background: Surgical resection of patients with resectable Stage IV colorectal cancer (CRC) is regarded as first choice if possible. However, its influence on overall survival (OS) has not been thoroughly explored. In this study, we aimed to construct nomograms to help predict 1-, 3- and 5-year OS rate and colorectal cancer-specific survival (CCSS) rate. Read More

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http://dx.doi.org/10.1093/jjco/hyz035DOI Listing

Efficacy of axitinib in patients with metastatic renal cell carcinoma refractory to nivolumab therapy.

Jpn J Clin Oncol 2019 Mar 29. Epub 2019 Mar 29.

Department of Urology, Tokyo Women's University Hospital, Tokyo, Japan.

We reviewed the clinical efficacy of axitinib after nivolumab treatment failure in six patients with metastatic renal cell carcinoma (RCC); the patients had received nivolumab treatment following vascular endothelial growth factor receptor (VEGFR) inhibitors. Most had undergone radical nephrectomy; five had clear-cell carcinoma and acquired cystic disease-associated carcinoma. The patients were finally diagnosed with progressive disease during nivolumab treatment. Read More

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http://dx.doi.org/10.1093/jjco/hyz040DOI Listing
March 2019
1 Read
1.747 Impact Factor

Systemic treatment of advanced esophageal squamous cell carcinoma: chemotherapy, molecular-targeting therapy and immunotherapy.

Jpn J Clin Oncol 2019 Mar 28. Epub 2019 Mar 28.

Department of Gastrointestinal Medical Oncology, National Cancer Center Hospital, Tokyo 104-0045, Japan.

Systemic treatment of advanced esophageal squamous cell carcinoma (ESCC) mainly consists of cytotoxic agents, aiming to palliate symptoms and prolong survival. Cisplatin and 5-fluorouracil have been considered standard treatment for several decades. Efforts to develop more effective treatment have led to clinical trials testing triplet, irinotecan-based, oxaliplatin-based and paclitaxel-based regimens. Read More

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http://dx.doi.org/10.1093/jjco/hyz034DOI Listing

Hyperprogression after pembrolizumab treatment in two patients with metastatic urothelial carcinoma.

Jpn J Clin Oncol 2019 Mar 28. Epub 2019 Mar 28.

Department of Urology, The Jikei University School of Medicine, Japan.

Hyperprogression has recently been recognized as a new pattern of progression in patients undergoing immune checkpoint inhibitor treatment. Here, we report two cases that showed hyperprogression during the initial phase of pembrolizumab treatment for metastatic urothelial carcinoma. The first patient, who received pembrolizumab as a second-line treatment, developed severe respiratory failure due to the rapid progression of lung metastases on the ninth day after the third pembrolizumab treatment. Read More

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http://dx.doi.org/10.1093/jjco/hyz038DOI Listing
March 2019
1 Read

Osimertinib for patients with EGFR T790M mutation-positive non-small-cell lung cancer and a poor performance status.

Jpn J Clin Oncol 2019 Mar 28. Epub 2019 Mar 28.

Division of Thoracic Oncology, Shizuoka Cancer Center, Shizuoka, Japan.

Background: Osimertinib is a third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) that is effective against EGFR T790M mutation-positive non-small-cell lung cancer (NSCLC) in patients who have good performance status (PS). However, the efficacy and safety of osimertinib for patients with poor PS is unknown.

Methods: We retrospectively evaluated the efficacy and safety of osimertinib in patients with EGFR T790M mutation-positive NSCLC who had Eastern Cooperative Oncology Group PS scores of 2-4 and who were administered 80 mg of osimertinib once daily between March 2016 and February 2017. Read More

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http://dx.doi.org/10.1093/jjco/hyz041DOI Listing
March 2019
2 Reads

Incidence rates of malignant lymphoma in the world from the Cancer Incidence in Five Continents XI.

Jpn J Clin Oncol 2019 Apr;49(4):393-394

Division of Cancer Statistics Integration, Center for Cancer Control and Information Services, National Cancer Center, Tokyo, Japan.

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http://dx.doi.org/10.1093/jjco/hyz043DOI Listing

Carboplatin, S-1 and concurrent thoracic radiotherapy for elderly patients with locally advanced non-small cell lung cancer: a multicenter Phase I/II study.

Jpn J Clin Oncol 2019 Mar 27. Epub 2019 Mar 27.

Department of Thoracic Oncology, National Cancer Center Hospital, Tokyo, Japan.

Objectives: We conducted a Phase I/II study of carboplatin, S-1 and concurrent thoracic radiotherapy (TRT) for elderly patients (71 years or older) with unresectable stage III non-small cell lung cancer (NSCLC).

Materials And Methods: Patients received carboplatin (AUC 3-5) on Day 1 and S-1 (30-40 mg/m2 two times daily) on Days 1-14, every 2 weeks, for up to four cycles, plus concurrent TRT at a total dose of 60 Gy. The primary endpoint for the Phase II study was the 1-year progression-free survival (PFS) rate. Read More

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http://dx.doi.org/10.1093/jjco/hyz039DOI Listing
March 2019
1 Read

Statistical inference for estimating the incidence of cancer at the prefectural level in Japan.

Jpn J Clin Oncol 2019 Mar 19. Epub 2019 Mar 19.

Hiroshima University, Graduate School of Science, Department of Mathematics, 1-3-1 Kagamiyama, Higashi-Hiroshima, Hiroshima 739-8526, Japan.

Information of prefectural cancer incidence in Japan is an important resource to plan an effective regional cancer control program. In order to obtain accurate prefectural cancer incidence, we have to adjust for both of completeness of regional cancer registries and regional dispersion, simultaneously, Then, we developed a hierarchal Bayes model with a completeness adjustment by using the relation between MI ratio (mortality divided by incidence) and proportion of death certificate notified among incidence. Prefectural cancer incidence is estimated with the 95% credible interval, which suggests that the national MI ratio should be 0. Read More

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http://dx.doi.org/10.1093/jjco/hyz033DOI Listing

The single-base-pair deletion, MSH2 c.2635-3delC affecting intron 15 splicing can be a cause of Lynch syndrome.

Jpn J Clin Oncol 2019 Mar 18. Epub 2019 Mar 18.

Department of Digestive Tract and General Surgery, Saitama Medical Center, Saitama Medical University, Saitama 350-8550, Japan.

The proband was a 62-year-old man with ureter cancer. He had a history of metachronous colorectal and gastric cancer. Immunohistochemical staining showed the absence of both MSH2 and MSH6 proteins in the ureter cancer and other available cancer tissue specimens. Read More

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http://dx.doi.org/10.1093/jjco/hyz031DOI Listing

Cryobiopsy during flex-rigid pleuroscopy: an emerging alternative biopsy method in malignant pleural mesothelioma. A comparative study of pathology.

Jpn J Clin Oncol 2019 Mar 18. Epub 2019 Mar 18.

Department of Pathology and Clinical Laboratories, Pathology Division, National Cancer Center Hospital, 5-1-1, Tsukiji Chou-ku, Tokyo 104-0045, Japan.

Background: Malignant pleural mesothelioma (MPM) is rarely an asbestos-related cancer with a poor prognosis that is difficult to distinguish from some benign conditions by using conventional biopsy techniques. The purpose of this study was to evaluate the utility of a novel biopsy technique using a cryoprobe during flex-rigid pleuroscopy for diagnosing MPM.

Methods: Consecutive patients who underwent pleural cryobiopsy during flex-rigid pleuroscopy from June through November 2017 to diagnose the cause of pleural effusion were collected. Read More

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http://dx.doi.org/10.1093/jjco/hyz032DOI Listing
March 2019
1 Read

Diagnostic value of rapid on-site evaluation during transbronchial biopsy for peripheral lung cancer.

Jpn J Clin Oncol 2019 Mar 11. Epub 2019 Mar 11.

Respiratory Department of Tianjin Medical University General Hospital, Tianjin 300052, China.

Background: An increasing number of pulmonary lesions-particularly, peripheral lung lesions-are identified with current technological advancements. Notably, the yield of traditional bronchoscopy for the diagnosis of peripheral lung lesions is low. This study evaluated the diagnostic value of rapid on-site evaluation (ROSE) during transbronchial biopsy for peripheral lung cancer. Read More

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http://dx.doi.org/10.1093/jjco/hyz025DOI Listing
March 2019
4 Reads

Learning curve and surgical outcomes for laparoscopic surgery, including pelvic lymphadenectomy, for early stage endometrial cancer.

Jpn J Clin Oncol 2019 Mar 11. Epub 2019 Mar 11.

Department of Obstetrics and Gynecology, Faculty of Medicine, Kagoshima University, Kagoshima, Japan.

Background: The purpose of this study was to determine the learning curve of laparoscopic surgery for the treatment of early endometrial cancer and report the surgical outcomes.

Methods: Patients: Data were retrospectively extracted from the medical charts of patients who underwent laparoscopic surgery.

Intervention: Laparoscopic surgery, including pelvic lymphadenectomy, was performed using the same technique and instruments for all patients. Read More

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http://dx.doi.org/10.1093/jjco/hyz027DOI Listing

Prognostic impact of TP53INP1 gene expression in estrogen receptor α-positive breast cancer patients.

Jpn J Clin Oncol 2019 Mar 11. Epub 2019 Mar 11.

Department of Breast Surgery, Nagoya City University Graduate School of Medical Sciences.

Background: Tumor protein 53-induced nuclear protein 1 (TP53INP1) is a key stress protein with tumor suppressor function. Several studies have demonstrated TP53INP1 downregulation in many cancers. In this study, we investigated the correlations of TP53INP1 mRNA expression in breast cancer tissues with prognosis and the correlations of microRNAs that regulate TP53INP1 expression in breast cancer patients with long follow-up. Read More

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http://dx.doi.org/10.1093/jjco/hyz029DOI Listing
March 2019
2 Reads

Green tea intake and colorectal cancer risk in Japan: the Takayama study.

Jpn J Clin Oncol 2019 Mar 11. Epub 2019 Mar 11.

Department of Epidemiology and Preventive Medicine, Gifu University Graduate School of Medicine, Gifu.

Background: Reportedly, green tea has a preventive effect against colorectal cancer in animal models. Nevertheless, results from epidemiological studies of the association between green tea consumption and colorectal cancer have been inconsistent. We aimed to evaluate colorectal cancer risk in relation to green tea consumption in a population-based prospective cohort study. Read More

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https://academic.oup.com/jjco/advance-article/doi/10.1093/jj
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http://dx.doi.org/10.1093/jjco/hyz030DOI Listing
March 2019
5 Reads

The updated points of TNM classification of urological cancers in the 8th edition of AJCC and UICC.

Jpn J Clin Oncol 2019 Mar 7. Epub 2019 Mar 7.

Department of Urology, Faculty of Medicine and Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan.

The Tumor-Node-Metastasis (TNM) staging system, jointly developed by the American Joint Commission on Cancer (AJCC) and the Union for International Cancer Control (UICC), is widely employed in clinical practice and research on patients with cancer. The definitions of TNM classification have recently been changed, improving patient stratification for management and prognosis. As the feature of new editions, biomarkers which are necessary for the stratification of patients are included to adapt for personalized medicine. Read More

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http://dx.doi.org/10.1093/jjco/hyz017DOI Listing

The role of elective neck dissection for cT4aN0 glottic squamous cell carcinoma.

Jpn J Clin Oncol 2019 Mar 4. Epub 2019 Mar 4.

Department of Head and Neck Surgery, National Cancer Center Hospital East, Kashiwa, Chiba, Japan.

Objective: The indication for elective neck dissection for patients with clinically T4aN0 (cT4aN0) glottic cancer is not established. The objective of this study was to evaluate the role of elective neck dissection for patients with cT4aN0 glottic cancer.

Methods: We assessed patients with cT4aN0 laryngeal squamous cell carcinoma who underwent total laryngectomy between 1998 and 2014 and conducted a retrospective analysis. Read More

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http://dx.doi.org/10.1093/jjco/hyz022DOI Listing
March 2019
5 Reads

Efficacy and safety of sunitinib in Japanese patients with progressive, advanced/metastatic, well-differentiated, unresectable pancreatic neuroendocrine tumors: final analyses from a Phase II study.

Jpn J Clin Oncol 2019 Apr;49(4):354-360

Hepatobiliary and Pancreatic Oncology Division, National Cancer Center Hospital, Tokyo 104-0045, Japan.

Background: In an interim analysis of a Phase II trial in Japanese patients with pancreatic neuroendocrine tumors (panNETs), sunitinib demonstrated antitumor activity with an objective response rate (ORR) of 50% (95% confidence interval [CI], 21-79) and a median progression-free survival (PFS) of 16.8 months (95% CI, 9.3-26. Read More

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http://dx.doi.org/10.1093/jjco/hyz009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452620PMC
April 2019
4 Reads

Surgical management around the paratracheal area of hypopharyngeal cancer.

Jpn J Clin Oncol 2019 Feb 28. Epub 2019 Feb 28.

Department of Head and Neck Surgery, National Cancer Center Hospital East, Kashiwa, Japan.

Objective: We aimed to clarify the suitable surgical management around the paratracheal area of patients who undergo total pharyngolaryngectomy based on the pathological results of hypopharyngeal cancer.

Methods: The study was conducted under a multicenter, retrospective observational design in Japan. We analyzed histopathological paratracheal lymph node metastasis and thyroid invasion, and recurrence around the paratracheal area for 184 patients who underwent initial surgery among 280 participants. Read More

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http://dx.doi.org/10.1093/jjco/hyz019DOI Listing
February 2019
1 Read

Plasma ctDNA monitoring during epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor treatment in patients with EGFR-mutant non-small cell lung cancer (JP-CLEAR trial).

Jpn J Clin Oncol 2019 Feb 27. Epub 2019 Feb 27.

Japanese Red Cross Medical Center, Shibuya,Tokyo, Japan.

Background: Osimertinib, a third generation epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor (TKI), is active against EGFR-mutant non-small cell lung cancer (NSCLC) resistant to first-/second-generation EGFR-TKIs with the T790M mutation. T790M monitoring in plasma circulating tumor DNA (ctDNA) in patients receiving EGFR-TKIs is less invasive than re-biopsy and could provide valuable clinical information.

Methods: Patients with advanced or postoperative recurrent NSCLC with sensitizing EGFR mutations who were planned to receive or were receiving first-/second-generation EGFR-TKI treatment without disease progression were eligible for enrollment. Read More

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http://dx.doi.org/10.1093/jjco/hyz023DOI Listing
February 2019
1 Read

Patient preference study comparing hypofractionated versus conventionally fractionated whole-breast irradiation after breast-conserving surgery.

Jpn J Clin Oncol 2019 Feb 23. Epub 2019 Feb 23.

Department of Radiation Oncology, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe City, Hyogo, Japan.

Objective: To compare patient preferences and acute adverse events of hypofractionated (HF) and conventionally fractionated (CF) whole-breast irradiation (WBI) after breast-conserving surgery in our institution.

Methods: We conducted a patient preference study comparing CF-WBI (50 Gy/25 fractions) and HF-WBI (41.6 Gy/16 fractions) after breast-conserving surgery. Read More

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http://dx.doi.org/10.1093/jjco/hyz003DOI Listing
February 2019

The dawn of robotic surgery in otolaryngology: head and neck surgery.

Jpn J Clin Oncol 2019 Feb 23. Epub 2019 Feb 23.

Department of Surgery, Division of Head and Neck Surgery, University of California San Diego, La Jolla, California, USA.

Transoral robotic surgery (TORS) utilizing the da Vinci robotic system has opened a new era for minimally-invasive surgery (MIS) in Otolaryngology-Head and Neck Surgery. Awareness of the historical steps in developing robotic surgery (RS) and understanding its current application within our field can help open our imaginations to future of the surgical robotics. We compiled a historical perspective on the evolution of surgical robotics, the road to the da Vinci surgical system, and conducted a review of TORS regarding clinical applications and limitations, prospective clinical trials and current status in Japan. Read More

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http://dx.doi.org/10.1093/jjco/hyz020DOI Listing
February 2019

Efficacy and safety of TC dose-dense chemotherapy as first-line treatment of epithelial ovarian cancer: a single-institution retrospective cohort study.

Jpn J Clin Oncol 2019 Apr;49(4):347-353

Department of Oncology, Clinical Hospital Center Split, Spinčićeva 1, 21000 Split, Croatia.

Background: The optimal first-line therapy of advanced ovarian cancer still remains questionable: standard paclitaxel-carboplatin (TC), dose-dense TC, intraperitoneal chemotherapy or TC plus bevacizumab. In this study, we present the real-life results of dose-dense treatment of the single-institution on Caucasian population.

Methods: A retrospective cohort study was used on consecutive samples of 74 patients treated with the conventional 3-weekly TC protocol (2008-11) and on 70 treated with TC dose-dense protocol (2012-16). Read More

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http://dx.doi.org/10.1093/jjco/hyz011DOI Listing

A randomized phase III trial of denosumab before curettage for giant cell tumor of bone: Japan Clinical Oncology Group Study JCOG1610.

Jpn J Clin Oncol 2019 Apr;49(4):379-382

Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan.

A randomized phase III trial was planned to commence in October 2017. Resectable giant cell tumor of bone (GCTB) without possible postoperative large bone defect has been treated by curettage with local adjuvant treatment, with the local recurrence rate found to be as high as 24.6-30. Read More

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http://dx.doi.org/10.1093/jjco/hyz004DOI Listing

Cervical laser vaporization for women with cervical intraepithelial neoplasia-3.

Jpn J Clin Oncol 2019 Feb 23. Epub 2019 Feb 23.

Division of Gynecologic Oncology, National Hospital Organization, Hokkaido Cancer Center, 4-2 Kikusui, Shiroishi-ku, Sapporo, Japan.

Objective: This study evaluated outcomes of laser vaporization of the cervix for women with cervical intraepithelial neoplasia (CIN)-3.

Methods: We retrospectively reviewed 161 consecutive patients with CIN3 who were treated with cervical laser vaporization between January 2008 and December 2012. At each follow-up visit, histologically confirmed CIN2, CIN3 and invasive carcinoma were defined as treatment failures, as were high-grade squamous intraepithelial lesion (HSIL) or atypical squamous cells that cannot exclude HSIL with subsequent treatment or lost to follow-up. Read More

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http://dx.doi.org/10.1093/jjco/hyz001DOI Listing
February 2019

Trends and projections of cancer mortality in Osaka, Japan from 1977 to 2032.

Jpn J Clin Oncol 2019 Apr;49(4):383-388

Center for Public Health Sciences, National Cancer Center Japan, 5-1-1 Tsukiji, Chuo-ku, Tokyo, Japan.

Projecting cancer mortality is fundamental to the process of planning cancer control. Although the prefecture is one of the main units for the implementation and evaluation of cancer control in Japan, a long-term detailed future projection of cancer mortality has not been conducted by prefecture. The main objective of this paper is to estimate the future number of cancer deaths in Osaka prefecture. Read More

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https://academic.oup.com/jjco/advance-article/doi/10.1093/jj
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http://dx.doi.org/10.1093/jjco/hyy204DOI Listing

Biomarker discordance between primary breast cancer and bone or bone marrow metastases.

Jpn J Clin Oncol 2019 Feb 22. Epub 2019 Feb 22.

Department of Breast and Medical Oncology, National Cancer Center Hospital.

Background: Discordance in biomarker expression between primary and metastatic tumor sites has been reported in several studies; yet, few have examined this feature in bone lesions.

Methods: We retrospectively enrolled patients with breast cancer metastasis to the bone or bone marrow, excluding cases where samples from both the primary and metastatic lesions were not available. Expression patterns of the estrogen receptor (ER), progesterone receptor (PgR), human epidermal growth factor receptor 2 (HER2) and Ki67 were compared in primary tumors and bone or bone marrow lesions. Read More

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http://dx.doi.org/10.1093/jjco/hyz018DOI Listing
February 2019
1 Read

Chemoradiotherapy for locally advanced lung cancer patients with interstitial lung abnormalities.

Jpn J Clin Oncol 2019 Feb 22. Epub 2019 Feb 22.

Department of Allergy and Respiratory Medicine, Okayama University Hospital.

Introduction: Although chemoradiotherapy for locally advanced lung cancer has the potential for cure, treatment is avoided in patients with interstitial lung disease because of the risk for severe radiation pneumonitis. Interstitial lung abnormalities (ILA) can be evaluated using high-resolution computed tomography (HRCT) to assess interstitial changes. In this study, we retrospectively examined the feasibility and efficacy of chemoradiotherapy for locally advanced lung cancer patients with ILA. Read More

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http://dx.doi.org/10.1093/jjco/hyz016DOI Listing
February 2019

What influences the willingness of cancer patients to receive hospice palliative care at end of life?

Jpn J Clin Oncol 2019 Apr;49(4):361-366

Department of Family, National Taiwan University Hospital, Taiwan.

Background: The benefits of hospice palliative care (HPC) for end-of-life (EoL) patients have been widely acknowledged in recent years. There is still limited knowledge about cancer patients' willingness toward HPC. This study aimed to investigate the willingness of cancer patients to receive HPC and the influencing factors. Read More

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http://dx.doi.org/10.1093/jjco/hyy199DOI Listing

Impact of tumor size on patient survival after radical nephrectomy for pathological T3a renal cell carcinoma.

Jpn J Clin Oncol 2019 Feb 22. Epub 2019 Feb 22.

Department of Urology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto.

Purpose: We recently reported the results from a multi-institutional retrospective outcome study involving 814 patients with renal cell carcinomas (RCCs) who had undergone radical surgery and whose diagnoses were confirmed via a central pathological review. This study aimed to clarify the impact of tumor size on survival outcomes in patients with pT3aN0M0 RCC after radical nephrectomy using this cohort.

Methods: Using the Kaplan-Meier method, overall survival (OS), cancer-specific survival (CSS) and relapse-free survival (RFS) were estimated for 103 pT3aN0M0 patients. Read More

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http://dx.doi.org/10.1093/jjco/hyy200DOI Listing
February 2019
1 Read

Attitude of Japanese palliative care specialists towards adjuvant analgesics cancer-related neuropathic pain refractory to opioid therapy: a nationwide cross-sectional survey.

Jpn J Clin Oncol 2019 Feb 22. Epub 2019 Feb 22.

Department of Psychosomatic Medicine, Kindai University Faculty of Medicine, Osakasayama City, Osaka, Japan.

Cancer-related neuropathic pain (CNP) requires therapy involving multiple pharmaceuticals, including anticonvulsants and antidepressants; however, strong evidence to support this practice is limited. This study is a cross-sectional questionnaire-based survey. As the standard dose of adjuvant analgesics for CNP refractory to opioid therapy is not clear, the purpose of this study is to clarify the opinions of specialists about the usage of duloxetine and pregabalin for patients with CNP refractory to opioid therapy. Read More

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http://dx.doi.org/10.1093/jjco/hyz002DOI Listing
February 2019
2 Reads

Smartphone problem-solving therapy to reduce fear of cancer recurrence among breast cancer survivors: an open single-arm pilot study.

Jpn J Clin Oncol 2019 Feb 22. Epub 2019 Feb 22.

Division of Psycho-Oncology and Palliative Care, Nagoya City University Hospital, Mizuho-cho, Mizuho-ku, Nagoya, Japan.

Objectives: The purpose of this study was to investigate a newly developed smartphone problem-solving therapy (PST) application's feasibility and preliminary effectiveness for reducing fear of cancer recurrence (FCR) among breast cancer survivors.

Methods: Female disease-free breast cancer survivors aged 20-49 years who were more than 6 months post-breast surgery participated in the study. The patients received the smartphone PST using an iPhone or iPad for 8 weeks. Read More

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http://dx.doi.org/10.1093/jjco/hyz005DOI Listing
February 2019

Kidney cancer incidence rates in the world from the Cancer Incidence in Five Continents XI.

Jpn J Clin Oncol 2019 Feb 21. Epub 2019 Feb 21.

Department of Mathematical Health Science, Graduate School of Medicine, Osaka University, Osaka, Japan.

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http://dx.doi.org/10.1093/jjco/hyz021DOI Listing
February 2019

Correlation between blood cell count and outcome of melanoma patients treated with anti-PD-1 antibodies.

Jpn J Clin Oncol 2019 Feb 12. Epub 2019 Feb 12.

Department of Dermatology, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.

Background: Anti-programmed cell death protein 1 monoclonal antibodies (αPD-1mAbs) have been shown to be effective for advanced malignant melanoma. Treatment with αPD-1mAbs can also cause immune-related adverse events (irAEs). However, clinical predictive factors for treatment responses or irAE risk remain unclear. Read More

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http://dx.doi.org/10.1093/jjco/hyy201DOI Listing
February 2019
5 Reads

Salvage surgery for small cell lung cancer after chemoradiotherapy.

Jpn J Clin Oncol 2019 Apr;49(4):389-392

Department of Thoracic Surgery, Aichi Cancer Center Hospital, 1-1 Kanokoden, Chikusa-ku, Nagoya 464-8681, Japan.

There are few reports on the use of salvage surgery for small cell lung cancer (SCLC). Five patients who underwent resection of post-chemoradiotherapy residual lesion/local reprogression of SCLC between 2005 and 2017 were included in the study. We retrospectively reviewed their surgical outcomes and prognosis to assess the feasibility and potential efficacy of salvage surgery. Read More

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http://dx.doi.org/10.1093/jjco/hyz010DOI Listing
April 2019
1 Read

Observational study of first-line chemotherapy including cetuximab in patients with metastatic colorectal cancer: CORAL trial.

Jpn J Clin Oncol 2019 Apr;49(4):339-346

Tokyo Medical and Dental University, Tokyo, Japan.

Objective: We aimed to clarify the clinical practice and outcomes of first-line cetuximab-containing chemotherapy in patients with metastatic colorectal cancer. Efficacy and safety were evaluated in each group classified by the European Society for Medical Oncology Guidelines 2012.

Methods: This prospective observational study included patients with previously untreated metastatic colorectal cancer from 158 centers in Japan who started first-line cetuximab-containing chemotherapy from January 2012 to June 2013 and were followed for up to 3 years. Read More

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http://dx.doi.org/10.1093/jjco/hyy189DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452621PMC
April 2019
8 Reads

Ki-67 labeling index as a predictor of response to neoadjuvant chemotherapy in breast cancer.

Jpn J Clin Oncol 2019 Apr;49(4):329-338

Medical Oncology, Rajiv Gandhi Cancer Institute & Research Centre, New Delhi, India.

Aims: To investigate Ki-67 index with regard to its ability to predict achievement of pathologic complete response (pCR) to neoadjuvant chemotherapy (NACT) in breast cancer patient.

Material And Methods: It was a prospective observational study, conducted in Department of Medical Oncology, Rajiv Gandhi Cancer Institute & Research Center (RGCIRC), New Delhi from February 2014 to March 2016. A total of 134 patients with Stage II/III breast cancer who underwent NACT followed by surgery at our center were enrolled and analyzed. Read More

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http://dx.doi.org/10.1093/jjco/hyz012DOI Listing

Histologic variants associated with biological aggressiveness and poor prognosis in patients treated with radical cystectomy.

Jpn J Clin Oncol 2019 Apr;49(4):373-378

Department of Urology, Kitasato University School of Medicine, Kanagawa 252-0374, Japan.

Background: The prognostic value of histologic variants (HV) after radical cystectomy (RC) remains controversial. We evaluated the clinicopathological features and prognosis in patients with pure urothelial carcinoma (UC) and HV following RC.

Methods: From 1990 to 2015, 286 patients with bladder cancer were treated with RC at six Kitasato University-affiliated hospitals. Read More

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http://dx.doi.org/10.1093/jjco/hyz015DOI Listing

Overview of current and future systemic therapy for metastatic renal cell carcinoma.

Jpn J Clin Oncol 2019 Feb 5. Epub 2019 Feb 5.

Department of Urology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.

Since the 2000s, there have been dramatic advances in the treatment of metastatic renal cell carcinoma (mRCC), including drugs targeting vascular endothelial growth factor (VEGF) and mammalian target of rapamycin (mTOR) pathways. The first VEGF inhibitors approved for mRCC were sorafenib and sunitinib. Subsequently, two mTOR inhibitors (everolimus and temsirolimus) and other VEGF inhibitors (pazopanib and axitinib) were approved. Read More

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https://academic.oup.com/jjco/advance-article/doi/10.1093/jj
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http://dx.doi.org/10.1093/jjco/hyz013DOI Listing
February 2019
6 Reads

Recurrent metastatic occult melanoma - Long-term remission after detection of the primary tumor by FDG-PET/CT.

Jpn J Clin Oncol 2019 Jan 31. Epub 2019 Jan 31.

Jena University Hospital, Clinic of Nuclear Medicine, Am Klinikum 1, Jena, Germany.

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https://academic.oup.com/jjco/advance-article/doi/10.1093/jj
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http://dx.doi.org/10.1093/jjco/hyz006DOI Listing
January 2019
6 Reads

Testis cancer incidence rates in the world from the Cancer Incidence in Five Continents XI.

Jpn J Clin Oncol 2019 Feb;49(2):199-200

Center for Cancer Registries, Center for Cancer Control and Information Services, National Cancer Center, Tokyo, Japan.

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http://dx.doi.org/10.1093/jjco/hyz007DOI Listing
February 2019