586,505 results match your criteria Japanese Journal of Clinical Oncology [Journal]


Interstitial Lung Disease Onset and Its Risk Factors in Japanese Patients with ALK-positive NSCLC Following Treatment with Crizotinib.

J Thorac Oncol 2018 Dec 3. Epub 2018 Dec 3.

Tokyo Medical University Hospital, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo 160-0023, Japan.

Introduction: The study objective was to determine the incidence and characteristics of drug-induced interstitial lung disease (ILD) associated with an orally available small-molecule tyrosine kinase inhibitor, crizotinib in the real-world clinical setting.

Methods: Post-marketing surveillance was performed in Japan to obtain information on the safety and efficacy of crizotinib. Target patients included all patients with anaplastic lymphoma kinase-positive non-small cell lung cancer (NSCLC) who received crizotinib, during the enrollment period between May 2012 and December 2014. Read More

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December 2018
5 Reads

Diagnosing the double burden of malnutrition using estimated deviation values in low- and lower-middle-income countries.

PLoS One 2018 6;13(12):e0208525. Epub 2018 Dec 6.

Department of International Health and Collaboration, National Institute of Public Health, Saitama, Japan.

Objective: To examine the possibility of diagnosing the double burden of malnutrition using estimated deviation values in low- and lower-middle-income countries.

Methods: A modified version of the Japanese Diagnostic Tool was used. Data on 194 countries were analyzed, including data from the United Nations International Children's Fund, World Health Organization and World Bank. Read More

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December 2018

Comparative genome analysis of Aspergillus flavus clinically isolated in Japan.

DNA Res 2018 Dec 5. Epub 2018 Dec 5.

Medical Mycology Research Center, Chiba University, Chiba City, Chiba, Japan.

Aspergillus flavus is an important zoonotic pathogen and a well-known aflatoxin producer. Aspergillus flavus strains that are prevalent in Japanese environments are reported to be non-aflatoxigenic, although their aflatoxin productivity, especially among clinical isolates, has not been thoroughly investigated to date. In this study, we sequenced the genomes of ten strains of A. Read More

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December 2018
1 Read

Hepatic neuroendocrine carcinoma in a Japanese macaque (Macaca fuscata).

J Med Primatol 2018 Dec 6. Epub 2018 Dec 6.

Primate Research Institute, Kyoto University, Aichi, Japan.

Primary neuroendocrine neoplasm of the liver is extremely rare in both humans and non-human primates. The present report describes the clinical and pathological findings of an aged Japanese macaque (Macaca fuscata) with hepatic neuroendocrine carcinoma. To our knowledge, this is the first report of hepatic neuroendocrine neoplasm in macaques. Read More

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December 2018
2 Reads

The QIAGEN 140-locus single-nucleotide polymorphism (SNP) panel for forensic identification using massively parallel sequencing (MPS): an evaluation and a direct-to-PCR trial.

Int J Legal Med 2018 Dec 5. Epub 2018 Dec 5.

National Centre for Forensic Studies, Faculty of Science & Technology, University of Canberra, Canberra, ACT, Australia.

Massively parallel sequencing (MPS) of identity informative single-nucleotide polymorphisms (IISNPs) enables hundreds of forensically relevant markers to be analysed simultaneously. Generating DNA sequence data enables more detailed analysis including identification of sequence variations between individuals. The GeneRead DNAseq 140 IISNP MPS panel (QIAGEN) has been evaluated on both the MiSeq (Illumina) and Ion PGM™ (Applied Biosystems) MPS platforms using the GeneRead DNAseq Targeted Panels V2 library preparation workflow (QIAGEN). Read More

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December 2018

Institutional patient accrual volume and the treatment quality of I‑125 prostate seed implantation in a Japanese nationwide prospective cohort study.

Strahlenther Onkol 2018 Dec 5. Epub 2018 Dec 5.

Japanese Foundation for Prostate Research, Tokyo, Japan.

Purpose: It is unclear whether experience at high-volume institute improves the treatment quality of prostate seed implantation. The aim of this study was to evaluate the effect of institutional experience on postimplant dosimetric parameters in a nationwide prospective cohort study.

Methods: From July 2005 to June 2007, 2354 patients were registered in the Japanese Prostate Cancer Outcome Study of Permanent I‑125 Seed Implantation (J-POPS), and 1126 patients treated with seed implantation alone were evaluated. Read More

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December 2018

The effectiveness of a Japanese style health program: comparison between Minowa, Japan and Rayong, Thailand.

Heliyon 2018 Nov 26;4(11):e00961. Epub 2018 Nov 26.

Shinshu University, Faculty of Education, 6-Ro Nishinagano, Nagano City, Nagano 380-8544, Japan.

Aim: This study aimed to appropriately establish a Japanese style healthcare program under the ISO9001:2008 (ISO: International Organization for Standardization) in Minowa, Japan and Rayong, Thailand to improve problem areas and inspect its effectiveness. Furthermore, we want to make this health promotion through ISO widely available in Asian countries and to make an international contribution.

Method: We implemented a 6-month health program in the c Rayong city, Thailand, and a 12 month health program in the Minowa town, Japan. Read More

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November 2018
1 Read

Allogeneic stem cell transplantation with reduced intensity conditioning for patients with adrenoleukodystrophy.

Mol Genet Metab Rep 2019 Mar 20;18:1-6. Epub 2018 Nov 20.

Department of Hematology and Oncology, Children' Medical Center, Japanese Red Cross Nagoya First Hospital, Nagoya, Japan.

Objective: The prognosis of adrenoleukodystrophy (ALD)with neurological involvement is generally dismal; however, allogeneic stem cell transplantation (SCT) is recognized as effective to stabilize or improve the clinical symptoms of ALD. Herein, we report the clinical outcomes of patients with ALD who consecutively underwent allogeneic stem cell transplantation with reduced intensity conditioning at our institution.

Patients: Sixteen patients with ALD, who were symptomatic (n = 14) or presymptomatic (n = 2), received SCT from 2010 to 2016. Read More

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March 2019
1 Read

West Nile virus in Algeria: a comprehensive overview.

New Microbes New Infect 2019 Jan 21;27:9-13. Epub 2018 Oct 21.

UMR VITROME, Aix-Marseille Université, IRD, Service de Santé des Armées, Assistance Publique-Hôpitaux de Marseille, IHU Méditerranée-Infection, Marseille, France.

West Nile virus (WNV) is a mosquito-borne virus belonging to the genus related to the Japanese encephalitis antigenic complex of family. It is transmitted by the bite of infected mosquitoes. The virus is maintained in a mosquito-bird-mosquito transmission cycle. Read More

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January 2019
1 Read

Age at First Birth and the Risk of Endometrial Cancer Incidence: A Pooled Analysis of Two Prospective Cohort Studies among Japanese Women.

J Cancer 2018 27;9(23):4422-4429. Epub 2018 Oct 27.

Division of Epidemiology, Department of Health Informatics and Public Health, Tohoku University School of Public Health, Graduate School of Medicine, Sendai, Japan.

Age at first birth has been increasing among women in developed countries. Meanwhile, endometrial cancer has also been increasing worldwide, being one of the most common female hormone-related cancers. The purpose of this study was to examine the association between age at first birth and the risk of endometrial cancer among Japanese women, and to examine the hypothesis that the recent increase in endometrial cancer incidence can be partly explained by the trend for increasing age at first birth. Read More

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October 2018
1 Read

First clinical experiences of concurrent bleeding control and intracranial pressure monitoring using a hybrid emergency room system in patients with multiple injuries.

World J Emerg Surg 2018 29;13:56. Epub 2018 Nov 29.

Division of Trauma and Surgical Critical Care, Osaka General Medical Center, 3-1-56 Bandai-Higashi, Sumiyoshi-ku, Osaka, 558-8558 Japan.

Background: The outcomes of multiple injury patients with concomitant torso hemorrhage and traumatic brain injury (TBI) are very poor. The hybrid emergency room system (HERS) is a trauma management system designed to complete resuscitation, computed tomography (CT), surgery, angioembolization, and intracranial pressure (ICP) monitoring all in one trauma resuscitation room without patient transfer. We aimed to review the outcomes of polytrauma patients who underwent concurrent bleeding control and ICP monitoring using the HERS. Read More

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November 2018
1 Read

Thrombotic Microangiopathy with Severe Proteinuria Induced by Lenvatinib for Radioactive Iodine-Refractory Papillary Thyroid Carcinoma.

Case Rep Oncol 2018 Sep-Dec;11(3):735-741. Epub 2018 Nov 12.

Division of Medical Oncology/Hematology, Department of Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.

Standard therapy for radioactive iodine (RAI)-refractory differentiated thyroid cancer (DTC) is multi-targeted kinase inhibitors (m-TKIs), represented by sorafenib and lenvatinib. One of the main target molecules of m-TKIs is vascular endothelial growth factor receptor (VEGF-R). m-TKIs are known to cause adverse reactions such as hypertension and proteinuria as a class effect. Read More

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November 2018

Evaluation of sodium intake for the prediction of cardiovascular events in Japanese high-risk patients: the ESPRIT Study.

Hypertens Res 2018 Dec 5. Epub 2018 Dec 5.

Cardiology Division, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.

The optimal level of sodium intake remains controversial, and the effects on a broad range of cardiovascular (CV) conditions remain unknown. The Evaluation of sodium intake for the prediction of cardiovascular events in Japanese high-risk patients (ESPRIT) is a prospective observational study designed to investigate whether sodium intake assessed by spot urine testing is associated with adverse CV events. A total of 520 patients who visited our cardiology clinic with various cardiovascular risk profiles were included. Read More

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December 2018

Transcriptional changes in the Japanese scallop (Mizuhopecten yessoensis) shellinfested by Polydora provide insights into the molecular mechanism of shell formation and immunomodulation.

Sci Rep 2018 Dec 5;8(1):17664. Epub 2018 Dec 5.

Key Laboratory of Mariculture & Stock Enhancement in North China's Sea, Ministry of Agriculture and Rural Affairs, Dalian Ocean University, Dalian, China.

The Japanese scallop (Mizuhopecten yessoensis) is one of the most important aquaculture species in Asian countries; however, it has suffered severe infection by Polydora in northern China in recent years, causing great economic losses. The Polydora parasitizes the shell of scallops, badly destroying the shell's structure. To investigate the molecular response mechanism of M. Read More

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December 2018

Stable factor structure of the Edinburgh Postnatal Depression Scale during the whole peripartum period: Results from a Japanese prospective cohort study.

Sci Rep 2018 Dec 5;8(1):17659. Epub 2018 Dec 5.

Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan.

Early detection of perinatal depression is an urgent issue. Our study aimed to examine the construct validity and factor structure of the Japanese version of the Edinburgh Postnatal Depression Scale (EPDS) from a prospective cohort study from pregnancy to postpartum. A total of 1075 women completed all items of the EPDS at four time points: early pregnancy, late pregnancy, 5 days postpartum and 1 month postpartum. Read More

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December 2018
1 Read

Investigation into Lipid Management in Acute Coronary Syndrome Patients from the EXPLORE-J Study.

J Atheroscler Thromb 2018 Dec 4. Epub 2018 Dec 4.

Department of Molecular Innovation in Lipidology, National Cerebral & Cardiovascular Center Research Institute.

Aims: The EXPLORE-J study aimed to assess lipid management in patients hospitalized for acute coronary syndrome (ACS) and their cardiovascular risk despite undergoing standard therapy. Here, we focused on background characteristics of patients in the EXPLORE-J study to elucidate the current lipid-lowering therapy and its issues in Japan.

Methods: In this multicenter, prospective, observational study (UMIN000018946), consecutive Japanese ACS patients who required hospitalization were registered between April 2015 and August 2016. Read More

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December 2018
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Ectopic fat, insulin resistance and metabolic disease in non-obese Asians: investigating metabolic gradation.

Authors:
Yoshifumi Tamura

Endocr J 2018 Dec 4. Epub 2018 Dec 4.

Department of Metabolism & Endocrinology, Juntendo University Graduate School of Medicine, Tokyo, Japan.

Although metabolic abnormalities commonly occur in non-obese Asians, their pathogenesis is not fully understood. Proton magnetic resonance spectroscopy has been used to analyze intracellular lipids in humans, and results suggest that ectopic fat accumulation in muscle and liver may induce insulin resistance in each tissue independently of obesity. Thus, measurement of ectopic fat currently plays an important role in the study of insulin resistance in non-obese Asians. Read More

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December 2018
4 Reads

Medical Castration is a Rare but Possible Trigger of Torsade de Pointes and Ventricular Fibrillation.

Int Heart J 2018 Dec 5. Epub 2018 Dec 5.

Department of Cardiovascular Medicine, Faculty of Medical Sciences, University of Fukui.

Prostate cancer is the most common non-cutaneous malignancy in men and has been steadily rising in an aging society. Medical castration therapy is effective for metastatic prostate cancer, but the proarrhythmic properties have not been reported. We present a 71-year-old Japanese man with metastasis prostate cancer that, during medical castration therapy, had torsades de pointes (TdP) with a QT prolongation and ventricular fibrillation (VF). Read More

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December 2018
1 Read

Comparative assessment of 24-hr primary skin irritation test and human patch test data with in vitro skin irritation tests according to OECD Test Guideline 439 (for quasi-drugs in Japan).

J Toxicol Sci 2018 ;43(12):751-768

Working Group on Alternatives to Primary Skin Irritation Test, Japanese Society of Alternatives to Animal Experiments (JSAAE).

The Organisation for Economic Co-operation and Development (OECD) Test Guideline (TG) 439 is an in vitro test method of reconstructed human epidermis (RhE), which was developed for hazard identification of irritating chemicals in accordance with a primary skin irritation test using rabbits with 4-hr exposure. A regulation for quasi-drugs in Japan requires data from primary skin irritation tests using rabbits to undergo 24-hr exposure, and this is used as an evidence for 24-hr closed patch tests in humans. In this study with the same chemicals, primary skin irritation test data using rabbits undergoing 24-hr exposure and a 24-hr occlusive human patch test data were analyzed by comparing the results obtained with four test methods adopted in OECD TG 439. Read More

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January 2018

The performance of an in vitro skin sensitisation test, IL-8 Luc assay (OECD442E), and the integrated approach with direct peptide reactive assay (DPRA).

J Toxicol Sci 2018 ;43(12):741-749

Department of Dermatology, Tohoku University Graduate School of Medicine.

In all current in vitro skin sensitisation assays, DMSO is used to dissolve water-insoluble chemicals. However, our previous study suggested the superiority of the modified IL-8 Luc assay (mIL-8 Luc), in which X-VIVO 15 is used to dissolve chemicals, over the original assay using DMSO (oIL-8 Luc). In this study, to confirm the superiority of the mIL-8 Luc, we first increased the number of chemicals examined and demonstrated the superiority of the mIL-8 Luc, in which the mIL-8 Luc provided 87. Read More

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January 2018

[Evaluation of real-time surveillance of influenza incidence in Kawasaki City by comparison using the National Epidemiological Surveillance of Infectious Diseases].

Nihon Koshu Eisei Zasshi 2018 ;65(11):666-676

Department of Environmental and Occupational Health, School of Medicine, Toho University, Tokyo, Japan.

Objectives In Japan, nationwide data of the incidence of infectious diseases have been collected via the National Epidemiological Surveillance of Infectious Diseases (NESID) since 1981. In addition, since March 2014, Kawasaki City has operated its own real-time surveillance (RTS) system to collect data of the incidence of influenza from medical institutions across the city. This study aimed to describe the characteristics of the RTS system and compare the two surveillance systems to improve measures against infectious diseases in the future. Read More

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January 2018

[Awareness of harm to others from secondhand smoke and smokers' interest in smoking cessation].

Nihon Koshu Eisei Zasshi 2018 ;65(11):655-665

Cancer Control Center, Osaka International Cancer Institute.

Objectives Because smoking presents various health hazards, smoking cessation is important for health promotion. It is known that awareness of the harm of smoking to smokers themselves is associated with attempts to quit. However, the association between smoking cessation and awareness of harm to others from secondhand smoke has not been well examined. Read More

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January 2018
6 Reads

[The relationship between sleep and subjective mental health at one month postpartum in Japanese women].

Nihon Koshu Eisei Zasshi 2018 ;65(11):646-654

Faculty of Psychology, Kansai University of Welfare Sciences.

Objectives This study aimed to separately ascertain and examine the association between sleep and mental health among primiparas and multiparas at one month postpartum.Methods The subjects were 234 primiparas and 223 multiparas (a total of 457) at one month postpartum who agreed to participate in the questionnaire survey during a health check-up at a maternity hospital. According to the delivery records, they had no history of mental diseases. Read More

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January 2018
1 Read

[Content analysis of newspaper reports on passive smoking regulations in Japan].

Nihon Koshu Eisei Zasshi 2018 ;65(11):637-645

School of Public Health, Graduate School of Medicine, The University of Tokyo.

Objectives Ever since Tokyo was awarded the privilege to host the 2020 Olympic Games, the Japanese Ministry of Health, Labour, and Welfare has worked toward implementing a ban on passive smoking. This study examined the present situation of passive smoking in Japan, and the coverage of passive smoking regulations in newspaper reports, based on a content analysis. This was followed by a comparison with the contents of the "White Paper on Tobacco," published by the Japanese Ministry of Health, Labour, and Welfare in August, 2016. Read More

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January 2018

[The Effectiveness of Counseling Using Preventative Informational Sheets with Climate and Environmental Data from Insurance Pharmacies in Preventing Worsened Asthma Symptoms].

Yakugaku Zasshi 2018 Dec 5. Epub 2018 Dec 5.

Drug Informatics, Faculty of Pharmacy, Meijo University.

We investigated the possibility that having pharmacists give asthma patients informational sheets on climate and environmental changes at insurance pharmacies during patient counseling might prevent the worsening of asthma symptoms. Patients with hyperlipidemia were comparative subjects. We created informational sheets about climate and environmental changes and their influence on asthma. Read More

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December 2018

Prognostic accuracy of different disseminated intravascular coagulation criteria in critically ill adult patients: a protocol for a systematic review and meta-analysis.

BMJ Open 2018 Dec 4;8(12):e024878. Epub 2018 Dec 4.

Division of Trauma and Surgical Critical Care, Osaka General Medical Center, Osaka, Japan.

Introduction: Disseminated intravascular coagulation (DIC) is a common and serious condition that can lead to poor outcomes in critically ill patients. To make a correct diagnosis and improve the outcome of patients with DIC, several organisations have put forward DIC scoring systems. However, which criteria is the best to use for diagnosing DIC remains a continuing controversy even though many studies have been conducted to validate the diagnostic accuracy of each DIC scoring system. Read More

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December 2018
1 Read

Prognostic factors affecting clinical outcomes after arthroscopic rotator cuff repair: importance of functional recovery by 3 months after surgery.

J Orthop Surg Res 2018 Dec 5;13(1):310. Epub 2018 Dec 5.

Department of Orthopedic Surgery, Kurume University Medical Center, 155-1 Kokubu-machi, Kurume, Fukuoka, 839-0863, Japan.

Background: To examine important factors that affect clinical outcomes following arthroscopic rotator cuff repair (ARCR).

Methods: Among 163 patients who underwent ARCR, we included 71 shoulders in 71 patients whose progress was monitored for > 2 years, postoperatively. We divided the patients into groups A (scores ≥ 83 points, 59 patients) and B (scores < 83 points, 12 patients) using the Japanese Orthopedic Association (JOA) score at 24 months. Read More

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December 2018
1 Read

Impact of anti-doping education and doping control experience on anti-doping knowledge in Japanese university athletes: a cross-sectional study.

Subst Abuse Treat Prev Policy 2018 Dec 5;13(1):44. Epub 2018 Dec 5.

Graduate School of Health and Sports Science, Juntendo University, 1-1 Hiraka-gakuendai, Inzai-shi, Chiba, 270-1695, Japan.

Background: This study was conducted to elucidate the anti-doping (AD) education, doping control experience, and AD knowledge according to the World Anti-doping Code (Code) of Japanese university athletes.

Methods: We collected data from 514 male athletes (M = 19.53 years, SD = 1. Read More

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December 2018
1 Read

Application of the CRISPR/Cas9 system for modification of flower color in Torenia fournieri.

BMC Plant Biol 2018 Dec 5;18(1):331. Epub 2018 Dec 5.

Iwate Biotechnology Research Center, 22-174-4, Narita, Kitakami, Iwate, 024-0003, Japan.

Background: CRISPR/Cas9 technology is one of the most powerful and useful tools for genome editing in various living organisms. In higher plants, the system has been widely exploited not only for basic research, such as gene functional analysis, but also for applied research such as crop breeding. Although the CRISPR/Cas9 system has been used to induce mutations in genes involved in various plant developmental processes, few studies have been performed to modify the color of ornamental flowers. Read More

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December 2018
1 Read

Posterior Sublaminar Wiring and/or Transarticular Screw Fixation for Reducible Atlantoaxial Instability Secondary to Symptomatic Os Odontoideum: A Neglected Technique?

Asian Spine J 2018 Dec 7. Epub 2018 Dec 7.

Department of Orthopedic Surgery, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Study Design: Retrospective case analysis.

Purpose: We retrospectively evaluated the clinical and radiological outcomes of posterior sublaminar wiring (PSLW) and/or transarticular screw fixation (TASF) for reducible atlantoaxial instability (AAI) secondary to os odontoideum.

Overview Of Literature: Limited information is available about the surgical outcomes of symptomatic os odontoideum with AAI. Read More

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December 2018
1 Read

Long-term prognosis of Japanese patients with biologicnaïve Crohn's disease treated with anti-tumor necrosis factor-α antibodies.

Intest Res 2018 Dec 3. Epub 2018 Dec 3.

Division of Gastroenterology, Department of Internal Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.

Background/aims: Few reports have described the long-term treatment outcomes of the anti-tumor necrosis factor-α antibody for Japanese Crohn's disease (CD) patients. The aim of this study was to evaluate them and clarify the clinical factors that affect the long-term prognosis of the anti-tumor necrosis factor-α treatments.

Methods: This was a retrospective, observational, single-center cohort study. Read More

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December 2018
1 Read

Osimertinib versus standard-of-care EGFR-TKI as first-line treatment for EGFRm advanced NSCLC: FLAURA Japanese subset.

Jpn J Clin Oncol 2018 Dec 1. Epub 2018 Dec 1.

Department of Medical Oncology, Kindai University Hospital, Ohno-higashi, Osaka, Japan.

Background: The FLAURA study was a multicenter, double-blind, Phase 3 study in which patients with previously untreated epidermal growth factor receptor mutation-positive advanced non-small-cell lung carcinoma were randomized 1:1 to oral osimertinib 80 mg once daily or standard-of-care (gefitinib 250 mg or erlotinib 150 mg, once daily) to compare safety and efficacy. In the overall FLAURA study, significantly better progression-free survival was shown with osimertinib versus standard-of-care.

Methods: Selected endpoints, including progression-free survival (primary endpoint), overall survival, objective response rate, duration of response and safety were evaluated for the Japanese subset of the FLAURA study. Read More

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December 2018
8 Reads

Analysis of apolipoprotein E genetic polymorphism in a large ethnic Hakka population in southern China.

Genet Mol Biol 2018 Nov 29. Epub 2018 Nov 29.

Center for Cardiovascular Diseases, Meizhou People's Hospital (Huangtang Hospital), Meizhou Academy of Medical Sciences, Meizhou Hospital Affiliated to Sun Yat-sen University, Meizhou, P.R. China.

There is currently no data about the genetic variations of APOE in Hakka population in China. The aim of this study was to analyze the allelic and genotypic frequencies of APOE gene polymorphisms in a large ethnic Hakka population in southern China. The APOE genes of 6,907 subjects were genotyped by the gene chip platform. Read More

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November 2018

Construction of a highly saturated linkage map in Japanese plum (Prunus salicina L.) using GBS for SNP marker calling.

PLoS One 2018 3;13(12):e0208032. Epub 2018 Dec 3.

Universidad de Chile, Facultad de Ciencias Agronómicas, Departamento de Producción Agrícola, Laboratorio de Genómica Funcional & Bioinformática, La Pintana, Santiago, Chile.

This study reports the construction of high density linkage maps of Japanese plum (Prunus salicina Lindl.) using single nucleotide polymorphism markers (SNPs), obtained with a GBS strategy. The mapping population (An x Au) was obtained by crossing cv. Read More

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December 2018
1 Read

Weight cycling and cardiovascular outcome in women with suspected ischemia: A report from the NHLBI-sponsored WISE Study.

PLoS One 2018 3;13(12):e0207223. Epub 2018 Dec 3.

Division of Cardiovascular Medicine, University of Florida, Gainesville, Florida, United States of America.

Background: We previously reported in a cross-sectional analysis an adverse relationship between weight cycling and HDL-cholesterol but not angiographic obstructive coronary artery disease (CAD) among women undergoing coronary angiography for suspected ischemia in the NHLBI-sponsored Women's Ischemia Syndrome Evaluation (WISE). We now examine the relationship between weight cycling and prospective adverse cardiovascular outcome in this group.

Methods: 795 women enrolled between 1996-2001 in the WISE undergoing coronary angiography for evaluation of suspected ischemia and followed for a median of 6. Read More

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December 2018
1 Read

Fasting blood glucose is predictive of hypertension in a general Japanese population.

J Hypertens 2019 Jan;37(1):167-174

Division of Renal Diseases and Hypertension, School of Medicine, University of Colorado Denver, Aurora, Colorado, USA.

Objective: This study was conducted to identify whether higher fasting blood glucose levels is predictive of hypertension by a large-scale longitudinal design.

Methods: We conducted a retrospective 5-year cohort study using the data from 13 201 Japanese individuals who underwent annual medical examinations in 2004 and were reevaluated 5 years later. This study included individuals without diabetes or hypertension between ages 30 and 85 years in 2004. Read More

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January 2019
1 Read

The Positive Effects of Viewing Gardens for Persons with Dementia.

J Alzheimers Dis 2018 Nov 28. Epub 2018 Nov 28.

Division of Life Science and the State Key Laboratory of Molecular Neuroscience, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong.

Dementia is highly prevalent among the worldwide elderly population. Only a small number of the currently marketed drugs are effective in controlling its symptoms, and none has any effect on its progression. Further, as the condition advances, even these pharmaceuticals lose their efficiency, and new research into interventions that might improve the life quality of patients at the end stage of dementia and their families is increasingly rare. Read More

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November 2018
1 Read

Beyond resumption of the Japanese Government's recommendation of the HPV vaccine.

Lancet Oncol 2018 Dec;19(12):1563-1564

Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Osaka 565-0871, Japan.

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December 2018
1 Read

Distribution of liver stiffness in nonalcoholic fatty liver disease with higher Fibrosis-4 index than low cut-off index.

J Gastroenterol Hepatol 2018 Dec 2. Epub 2018 Dec 2.

Department of Gastroenterology and Hepatology, Yokohama City University Graduate School of Medicine, Japan.

Background And Aim: In the condition of high prevalence of nonalcoholic fatty liver disease (NAFLD), a new diagnostic algorithm to efficiently identify NAFLD patients with significant fibrosis is urgently required. We evaluated the predictive ability of the Fibrosis-4 index (FIB-4 index) for significant liver fibrosis (F ≥ 2) in a cohort of Japanese patients with NAFLD.

Methods: We prospectively calculated the FIB-4 index in patients who were incidentally diagnosed as fatty liver in medical checkups, and then conducted liver stiffness measurement (LSM) by vibration-controlled transient elastography (VCTE) only in patients in whom the FIB-4 index was more than the low cut-off index (> 1. Read More

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December 2018
1 Read

A subanalysis of Japanese patients in a randomized, double-blind, placebo-controlled, phase 3 trial of nivolumab for patients with advanced gastric or gastro-esophageal junction cancer refractory to, or intolerant of, at least two previous chemotherapy regimens (ONO-4538-12, ATTRACTION-2).

Gastric Cancer 2018 Dec 1. Epub 2018 Dec 1.

Division of Gastrointestinal Medical Oncology, National Cancer Center Hospital, 5-1-1, Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.

Background: Nivolumab, an anti-programmed death-1 agent, showed survival benefits in Asian patients, including Japanese, with gastric/gastro-esophageal junction (G/GEJ) cancer. We report the analysis of the Japanese subpopulation from ATTRACTION-2 that evaluated nivolumab versus placebo in unresectable advanced or recurrent G/GEJ cancer after ≥ 2 chemotherapy regimens.

Methods: Data from the Japanese subpopulation in the randomized, double-blind, placebo-controlled, phase 3 trial were analyzed (data cutoff, February 25, 2017). Read More

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December 2018
3 Reads

Associations of temporal changes in cervical length and lower uterine segment length with spontaneous preterm delivery risk: a prospective study of 727 Japanese women.

J Med Ultrason (2001) 2018 Dec 1. Epub 2018 Dec 1.

Maternal and Child Health Center Aiiku Hospital, 1-16-10 Shibaura, Minato-ku, Tokyo, 105-0023, Japan.

Purpose: A prospective assessment of the risk of spontaneous preterm delivery (sPTD) by evaluating temporal changes in cervical measurements.

Methods: We analyzed clinical variables, focusing on cervical length (CL) and lower uterine segment (LUS) length (LUSL) as measured by transvaginal ultrasonography in 727 pregnant Japanese women.

Results: In women undergoing term deliveries, CL increased from gestational week (GW) 8-25. Read More

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December 2018
2 Reads

Isocitrate dehydrogenase gene mutations and 2-hydroxyglutarate accumulation in esophageal squamous cell carcinoma.

Med Oncol 2018 Nov 30;36(1):11. Epub 2018 Nov 30.

Department of Gastroenterological Surgery, Graduate School of Medical Science, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, 860-8556, Japan.

Isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) are key metabolic enzymes that convert isocitrate to α-ketoglutarate. Somatic point mutations in IDH1/2 confer a gain-of-function in cancer cells, resulting in overproduction of an oncometabolite, 2-hydroxyglutarate (2HG). 2HG interferes with cellular metabolism and epigenetic regulation, contributing to oncogenesis. Read More

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November 2018

Effect of early administration of coagulation factor XIII on fistula after pancreatic surgery: the FIPS randomized controlled trial.

Langenbecks Arch Surg 2018 Nov 30. Epub 2018 Nov 30.

Department of Hepatobiliary-Pancreatic Surgery, Japanese Foundation for Cancer Research, Cancer Institute Hospital, 3-8-31 Ariake, Koto-ku, Tokyo, 135-8550, Japan.

Purpose: The administration of exogenous factor XIII (FXIII) is reportedly effective for fistula closure in patients with a low plasma FXIII level. This study was performed to analyze the effect of early administration of exogenous FXIII on postoperative pancreatic fistula (POPF).

Methods: A single-center randomized controlled, open-label, parallel group, superiority trial was conducted from October 2015 to August 2016 in Japan. Read More

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November 2018
1 Read

A cross-sectional study to assess the awareness and practices related to adult immunization among nursing students in a metropolitan city.

J Educ Health Promot 2018 29;7:129. Epub 2018 Oct 29.

Department of Community Medicine, Seth G. S. Medical College and KEM Hospital, Mumbai, Maharashtra, India.

Introduction: Immunization against vaccine-preventable diseases in adults is the need of the hour. The student nurses by virtue of training are the frontline health workers dealing with patient care. They are exposed to maximum risk of contracting the diseases. Read More

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October 2018
1 Read

Plasmid DNA vaccine coding eight repeats of gonadotrophin-releasing hormone induced atrophy of prostate in male mice.

Prostate Int 2018 Dec 12;6(4):151-156. Epub 2018 Jan 12.

Department of Pathology, Faculty of Veterinary Science, Bangladesh Agricultural University, Mymensingh, Bangladesh.

Background: Prostate hyperplasia and neoplasia are major illness of men and elderly dogs. Treatment of prostate cancer requires androgen deprivation surgery or therapy to prevent metastases and alleviate pain. Recently, six DNA vaccines have entered clinical trials against prostate cancer in humans with limited success. Read More

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December 2018

Interstitial lung disease associated with anti-citrullinated peptide/protein antibody-positive anti-synthetase syndrome.

J Thorac Dis 2018 Oct;10(10):5924-5931

Department of Respiratory Medicine, Kanagawa Cardiovascular and Respiratory Center, Kanazawa-ku, Yokohama 236-0051, Japan.

Little has been reported on the characteristics of interstitial lung disease (ILD) associated with anti-citrullinated peptide/protein antibody (ACPA)-positive anti-synthetase syndrome (ASS). We sought to investigate the clinical, radiologic, and pathologic features of patients with ILD associated with ACPA-positive ASS. Medical records of seven ILD patients with positive results of both ACPA and anti-aminoacyl-tRNA synthetase antibody were retrospectively reviewed. Read More

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October 2018

Is early goal-directed therapy associated with a higher risk of adverse events?

J Intensive Care 2018 26;6:78. Epub 2018 Nov 26.

Intensive Care Unit, Okba Ben Nafee Hospital, 45 street, el-Asafra, Alexandria, 21539 Egypt.

The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2016 suggested against the use of the early goal-directed therapy (EGDT) in patients with septic shock. This recommendation was based on the three large-scale trials (ProCESS, ARISE, and ProMISe). Although the three trials showed no difference in mortality between EGDT and usual care, the guidelines determined that the potential harms presented by EGDT likely outweigh its potential benefits. Read More

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November 2018
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Employment and health after retirement in Japanese men.

Bull World Health Organ 2018 Dec 27;96(12):826-833. Epub 2018 Sep 27.

Faculty of Economics, Keio University, Tokyo, Japan.

Objective: To estimate the average treatment effect of working past the current retirement age on the health of Japanese men.

Methods: We used publicly available data from the National Survey of Japanese Elderly, extracting a sample of 1288 men who were 60 years or older. Survey respondents were followed-up for at most 15 years for the onset of four health outcomes: death, cognitive decline, stroke and diabetes. Read More

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December 2018
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[Analysis of Time-to-onset and Onset-pattern of Interstitial Lung Disease after the Administration of Monoclonal Antibody Agents].

Yakugaku Zasshi 2018 ;138(12):1587-1594

Faculty of Pharmaceutical Sciences, Himeji Dokkyo University.

The aim of this study has been to investigate the time-to-onset and onset-pattern of drug-induced interstitial lung disease (DILD) after the administration of monoclonal antibodies through the use of the spontaneous adverse reaction reporting system of the Japanese Adverse Drug Event Report database. DILD datasets for adalimumab, bevacizumab, cetuximab, denosumab, golimumab, infliximab, nivolumab, panitumumab, pembrolizumab, tocilizumab, and trastuzumab were used to calculate the median time-to-onset of DILD, as well as the Weibull distribution parameters. The median time-to-onset of DILD for pembrolizumab and infliximab was within 1 month. Read More

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January 2018
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