587,311 results match your criteria Japanese Encephalitis


Cases of prolonged mild disturbance of consciousness and acute encephalopathy.

Pediatr Int 2018 Dec 15. Epub 2018 Dec 15.

Division of Neurology, National Center for Child Health and Development, Tokyo, Japan 2-10-1 Okura, Setagaya-ku, Tokyo, 157-8535, Japan.

Background: Acute encephalopathy (AE) is defined by the Japanese guidelines as the acute disturbance of consciousness (Glasgow Coma Scale score ≤11) that persists for more than 24 hours. However, we have often encountered cases of prolonged mild disturbance of consciousness (PMDC) with Glasgow Coma Scale scores >11 that do not fit the definition of acute encephalopathy by the guidelines. The reports of these cases have been relatively sparse, and their nosological position, prognosis, and other characteristics remain unknown. Read More

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December 2018

Recurrence Patterns and Outcomes of Salvage Surgery in Cases of Non-Curative Endoscopic Submucosal Dissection without Additional Radical Surgery for Early Gastric Cancer.

Digestion 2018 Dec 14;99(1):52-58. Epub 2018 Dec 14.

Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan.

Background/aims: The outcomes of salvage surgery for recurrence after non-curative endoscopic submucosal dissection (ESD) without additional radical surgery for early gastric cancer (EGC) remain unclear. We determined the recurrence patterns and outcomes of salvage surgery in such cases using data from a multicenter, retrospective study.

Methods: Of 15,785 patients who underwent ESD for EGC at 19 participating institutions between January 2000 and August 2011, 1,969 failed to meet the current curative criteria after ESD. Read More

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December 2018
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The Incidence and Risk Factors of Venous Thromboembolism in Patients with Inflammatory Bowel Disease: A Prospective Multicenter Cohort Study.

Digestion 2018 Dec 14:1-9. Epub 2018 Dec 14.

Division of Gastroenterology and Hematology/Oncology, Department of Medicine, Asahikawa Medical University, Asahikawa, Japan.

Background: Venous thromboembolism (VTE) has been shown to be more frequent in inflammatory bowel disease (IBD) than in the general population in Western studies. However, the actual state of VTE in Asian IBD remains poorly understood.

Aims: To reveal the incidence of VTE in IBD patients in Japan. Read More

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December 2018

The 14th Annual Meeting of the Japanese Gastroenterological Association.

Authors:

Digestion 2018 Dec 14;99(1). Epub 2018 Dec 14.

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December 2018

Recent Incidence Trend of Surgically Resected Esophagogastric Junction Adenocarcinoma and Microsatellite Instability Status in Japanese Patients.

Digestion 2018 Dec 14;99(1):6-13. Epub 2018 Dec 14.

Department of Gastroenterological Surgery, Cancer Institute Hospital of Japanese Foundation of Cancer Research, Tokyo, Japan.

Background: The incidence trend of esophagogastric junction (EGJ) adenocarcinoma in Japan has not been sufficiently investigated. Little is known about the microsatellite instability (MSI) status of this tumor.

Summary: Previously published studies analyzing the trend of EGJ adenocarcinoma in Japan were reviewed. Read More

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December 2018

Auspicious or suspicious - Does religiosity really promote elder well-being? Examining the belief-as-benefit effect among older Japanese.

Arch Gerontol Geriatr 2018 Dec 7;81:129-135. Epub 2018 Dec 7.

Charles Sturt University, Bathurst, NSW, Australia. Electronic address:

Recent findings suggest that the belief-as-benefit effect (BABE) - the positive association between religiosity and health/well-being - is a spurious correlation voided by personality traits. The current paper investigates the cross-sectional relationships among personality, religiosity and psychological well-being in an older adult sample randomly-selected from Tokyo, Japan. Correlation and Hierarchical Regression Modelling (HRM)-with a two one-sided test (TOST) of equivalence-is utilized. Read More

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December 2018

Transcatheter aortic valve replacement outcomes in Japan: Optimized CathEter vAlvular iNtervention (OCEAN) Japanese multicenter registry.

Cardiovasc Revasc Med 2018 Dec 4. Epub 2018 Dec 4.

Department of cardiology, Keio University School of Medicine, Tokyo, Japan.

Objectives: We aimed to assess real-world clinical outcomes of transcatheter aortic valve replacement (TAVR) in Japan.

Background: Data are limited concerning procedural safety and valve performance following TAVR in Japanese. A program by an on-site proctor and procedure screening system was applied during TAVR introduction. Read More

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December 2018

Lamellarin-inspired potent topoisomerase I inhibitors with the unprecedented benzo[g][1]benzopyrano[4,3-b]indol-6(13H)-one scaffold.

Bioorg Med Chem 2018 Nov 28. Epub 2018 Nov 28.

Division of Chemistry and Materials Science, Graduate School of Engineering, Nagasaki University, 1-14 Bunkyo-machi, Nagasaki 852-8521, Japan. Electronic address:

A new class of topoisomerase I inhibitors containing the unprecedented benzo[g][1]benzopyrano[4,3-b]indol-6(13H)-one (abbreviated as BBPI) ring system have been developed based on structure-activity relationship studies of the cytotoxic marine alkaloid lamellarin D. The pentacyclic BBPI scaffold was constructed from N-tert-butoxycarbonylpyrrole by sequential and regioselective functionalization of the pyrrole core using directed lithiation, conventional electrophilic substitution, and palladium-catalyzed cross-coupling reactions. Further N-alkylation of the scaffold followed by selective deprotection of the O-isopropyl group produced a range of N-substituted BBPI derivatives. Read More

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November 2018

Hereditary cardiac amyloidosis associated with Pro24Ser transthyretin mutation: a case report.

J Med Case Rep 2018 Dec 16;12(1):370. Epub 2018 Dec 16.

Department of Clinical Research, Chiba Tokushukai Hospital, Chiba, Japan.

Background: Transthyretin amyloidosis is a systemic disorder caused by extracellular deposition of insoluble amyloid fibrils in peripheral and autonomic nerves, heart, kidney, gastrointestinal tract, and other organs. Hereditary transthyretin amyloidosis is an autosomal dominant disease. More than 120 mutations have been reported in the transthyretin gene with considerable phenotypic heterogeneity and geographic diversity. Read More

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December 2018

An exploration of the psychometric properties of the SATAQ-4 among adolescent boys in Japan.

Eat Behav 2018 Dec 6;32:31-36. Epub 2018 Dec 6.

Department of Psychology, University of South Florida, Tampa, FL, USA.

Research among Western adult and adolescent males suggests that sociocultural influences are implicated in the drive for muscularity and weight-change behaviors. However, few studies have examined these relationships among adolescent boys from non-Western backgrounds. The current study sought to assess the psychometric properties of the Sociocultural Attitudes Towards Appearance Questionnaire-4 (SATAQ-4), a 22-item, 5-factor measure of sociocultural influence on appearance ideals, among Japanese (n = 984) adolescent boys. Read More

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December 2018
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Feasibility of transcatheter prosthetic paravalvular leakage closure: a single-center, exploratory safety evaluation study of transcatheter closure of prosthetic paravalvular regurgitation in Japan (STOP PARA study).

Gen Thorac Cardiovasc Surg 2018 Dec 14. Epub 2018 Dec 14.

Department of Cardiovascular Surgery, National Cerebral and Cardiovascular Center, Suita, Japan.

Objective: The standard treatment of prosthetic paravalvular leakage (PVL) accompanied by heart failure or hemolytic anemia is repeat open surgery. Although favorable outcomes for transcatheter prosthetic PVL closure in patients with a high surgical risk for repeat open surgery have been reported, procedural feasibility has not been examined in Japan.

Methods: From March 2015 to November 2015, transcatheter PVL closure in mitral position was performed in four patients (age range 41-78, three females) with high surgical risk due to history of repeated surgeries, chest radiation and reconstruction of the mitral annulus after debridement of abscess owing to infective endocarditis. Read More

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December 2018
2 Reads

Suvorexant (Belsomra Tablets 10, 15, and 20 mg): Japanese Drug-Use Results Survey.

Drugs R D 2018 Dec 14. Epub 2018 Dec 14.

Pharmacovigilance, MSD K.K., Tokyo, Japan.

Background: We report on the results of a Japanese postmarketing drug-use survey of suvorexant (Belsomra) tablets.

Methods: A survey with a ≤ 6-month observation period after the start of administration was conducted, targeting insomnia patients who were treated with suvorexant for the first time in Japan. Information on the safety and efficacy of the drug product was collected. Read More

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December 2018
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A novel partner of TFE3 in the Xp11 translocation renal cell carcinoma: clinicopathological analyses and detection of EWSR1-TFE3 fusion.

Virchows Arch 2018 Dec 14. Epub 2018 Dec 14.

Medical Mycology Research Center, Chiba University, Chiba, Japan.

The renal cell carcinomas associated with Xp11 translocations (Xp11 translocation RCCs) harbor gene fusions involving TFE3, a member of the microphthalmia-associated transcription factor (MiTF) family. In the present study, we identified a novel partner of TFE3, Ewing sarcoma breakpoint region 1 (EWSR1), in an Xp11 translocation RCC. A 57-year-old Japanese woman without special disease history was referred to us for treatment of an RCC. Read More

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December 2018
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Immunohistochemical evaluation of tumor budding for stratifying T1 colorectal cancer: optimal cut-off value and a novel computer-assisted semiautomatic method.

Mod Pathol 2018 Dec 14. Epub 2018 Dec 14.

Division of Pathology, The Cancer Institute; Department of Pathology, The Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, 135-8550, Japan.

High-grade tumor budding is an adverse prognostic factor for submucosal invasive (T1) colorectal cancer used to predict the risk for lymph node metastasis in endoscopically resected specimens. Cytokeratin immunohistochemistry is a potential option for evaluating tumor budding. The optimal cut-off value between low- and high-grade budding has not yet been determined, however, and the high inter-observer variability in selecting budding foci remains problematic. Read More

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December 2018

A genome-Wide Association Study Confirming a Strong Effect of HLA and Identifying Variants in on Chromosome 12q13.13 Associated with Susceptibility to Fulminant Type 1 Diabetes.

Diabetes 2018 Dec 14. Epub 2018 Dec 14.

Department of Endocrinology, Metabolism and Diabetes, Kindai University Faculty of Medicine, Osaka, Japan

The first genome-wide association study of fulminant type 1 diabetes mellitus was performed in Japanese individuals. As previously reported using a candidate gene approach, a strong association was observed with multiple SNPs in the HLA region, and the strongest association was observed with rs9268853 in the class II DR region (P=1.56 x 10, odds ratio [OR] 3. Read More

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December 2018
2 Reads

Treatment of asthma in smokers: A questionnaire survey in Japanese clinical practice.

Respir Investig 2018 Dec 11. Epub 2018 Dec 11.

Department of Respiratory Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan. Electronic address:

Background: Cigarette smoking in patients with asthma leads to poor symptom control. As patients who are current smokers have been excluded from enrollment in many clinical trials on asthma, there are few reports on the treatment in current smokers with asthma. In this study, we aimed to assess how respiratory physicians manage asthma in current smokers in Japan. Read More

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December 2018

Interleukin 8 targeted contrast echocardiography is effective to evaluate myocardial ischemia-reperfusion injury in the rabbits.

Biomed Pharmacother 2019 Jan 9;109:1346-1350. Epub 2018 Nov 9.

Department of Ultrasound, Shanghai Sixth People's Hospital, Shanghai, China.

Interleukin 8 (IL-8) is an important pro-inflammatory cytokine that recruits neutrophil to the areas of inflammation and has been implicated in myocardial ischemia reperfusion injury (MIRI). This study aimed to apply IL-8 targeted myocardial contrast echocardiography (MCE) to evaluate MIRI in rabbits. MCE imaging with IL-8 targeted microbubbles (MB) and control microbubbles (MB) was performed in 40 Japanese white rabbits after brief proximal left anterior descending (LAD) partial occlusion for 30 min and subsequent reperfusion for 30 min, 60 min, 120 min and 180 min. Read More

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January 2019
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Masked ambiguity - Emotion identification in schizophrenia and major depressive disorder.

Psychiatry Res 2018 Dec 28;270:852-860. Epub 2018 Oct 28.

Department of Psychology, Kawamura Gakuen Women's University, Faculty of Liberal Arts, 1133 Sageto, Abiko-city, Chiba 270-1138, Japan. Electronic address:

Both patients with schizophrenia and with a major depressive disorder (MDD) display deficits in identifying facial expressions of emotion during acute phases of their illness. However, specific deficit patterns have not yet been reliably demonstrated. Tasks that employ emotionally ambiguous stimuli have recently shown distinct deficit patterns in patients with schizophrenia compared to other mental disorders as well as healthy controls. Read More

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December 2018
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Link of negative core beliefs about the self with perceived dysfunctional parenting.

Psychiatry Res 2018 Dec 25;270:715-719. Epub 2018 Oct 25.

Department of Psychiatry, Yamagata University School of Medicine, 2-2-2 Iidanishi, Yamagata 990-9585, Japan.

Cognitive theory posits the central role of negative core beliefs about the self in cognitive vulnerabilities to depression, and this position is supported by empirical studies. It is also hypothesized that these core beliefs develop as a result of negative interactions with significant others in early life. To test the hypothesis that negative core beliefs about the self are formed by dysfunctional parenting, we examined their relations with perceived parental rearing. Read More

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December 2018
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A 29-Year-Old Japanese Man Returning From Indonesia With Diffuse Maculopapular Rash.

Clin Infect Dis 2019 Jan;68(1):165-167

Center for Global Health, Mito Kyodo General Hospital, University of Tsukuba.

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January 2019
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Associations between cognitive impairment and quality of life in euthymic bipolar patients.

Psychiatry Res 2018 Nov 26;271:510-515. Epub 2018 Nov 26.

Department of Psychiatry, Graduate School of Medicine, Hokkaido University, Sapporo, Japan.

During the euthymic state in bipolar disorder, cognitive functions often remain affected. Specifically, subjective and objective cognitive impairment might distinctly affect patients' quality of life (QoL); however, this question had not been examined previously in Japanese patients. Therefore, the current study investigated the associations between cognitive complaints, QoL, and objective cognitive functions. Read More

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November 2018
3 Reads

Vertico-horizontal atlantoaxial index (VHAI): A new craniovertebral radiographic index.

Clin Neurol Neurosurg 2018 Dec 3;176:83-88. Epub 2018 Dec 3.

Department of Neurosurgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. Electronic address:

Objective: The purpose of this study was to develop a new index that can reliably quantify the reduction of basilar invagination with atlantoaxial dislocation.

Patients And Methods: Between May 2012 and September 2017, 40 patients with congenital basilar invagination and atlantoaxial dislocation as well as 100 sex-and age-matched control subjects were recruited for this study. All patients underwent direct posterior reduction and fixation. Read More

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December 2018

Associations of Patient Experience in Primary Care With Hospitalizations and Emergency Department Visits on Isolated Islands: A Prospective Cohort Study.

J Rural Health 2018 Dec 14. Epub 2018 Dec 14.

Department of Family and Community Medicine, Hamamatsu University School of Medicine, Higashi-ku, Hamamatsu, Shizuoka, Japan.

Purpose: In rural areas, the management of hospitalizations and emergency department (ED) visits is an important issue, and it is compounded by factors such as the long distance to secondary care facilities, funding difficulties in many rural medical institutions, and shortage of medical staff. While better patient experience (PX) has been shown to reduce hospitalizations and ED visits, previous studies have not considered the differences between urban and rural areas. In addressing this gap, this study examines the association between PX and hospitalizations/ED visits on isolated islands. Read More

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December 2018

Augmented ILT3/LILRB4 Expression of Peripheral Blood Antibody Secreting Cells in the Acute-Phase of Kawasaki Disease.

Pediatr Infect Dis J 2018 Dec 13. Epub 2018 Dec 13.

Department of Pediatrics, Sendai Medical Center, 2-8-8 Miyagino, Sendai 983-8520, Japan.

Background: Kawasaki disease (KD) is an acute, systemic vasculitis syndrome that occurs in children. The clinical symptoms and epidemiological features of KD strongly suggest that KD is triggered by unidentified infectious agents in genetically predisposed patients. In addition, a number of studies have described the role of B cells in the development of KD. Read More

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December 2018

Full-genome analysis of hepatitis C virus in Japanese and non-Japanese patients coinfected with HIV-1 in Tokyo.

J Acquir Immune Defic Syndr 2018 Dec 6. Epub 2018 Dec 6.

AIDS Clinical Center and.

Background: Acute hepatitis C virus (HCV) infection is increasing among HIV-1-infected individuals in Tokyo. Appropriate clinical management is needed.

Setting: To delineate the epidemiological status of HCV transmission, we analyzed stocked plasma samples of HCV/HIV-1-coinfected patients seen at the largest referral center for HIV care in Tokyo. Read More

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December 2018
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The impact of anti-vascular endothelial growth factor agents on visual impairment/blindness prevention in patients with diabetic macular edema and on associated patient and caregiver burden in Japan.

J Med Econ 2018 Dec 14:1-28. Epub 2018 Dec 14.

e Market Access, Health Economics and Outcomes Research , Bayer Yakuhin, Ltd , Tokyo , Japan.

Aims: To estimate the impact of anti-vascular endothelial growth factor (VEGF) agents on visual impairment and blindness avoided in patients with diabetic macular edema (DME) and on associated patient and caregiver productivity loss in Japan.

Methods: We compared the impact of current care (estimated at 53.8% utilization of anti-VEGF agents using current data) with that of hypothetical care (characterized by a higher utilization of anti-VEGF agents [80. Read More

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December 2018
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Combination of electrohydraulic lithotripsy and laparoscopy for gallbladder access in type III Mirizzi syndrome.

Asian J Endosc Surg 2018 Dec 13. Epub 2018 Dec 13.

Division of Surgery, Gastroenterological Center, Medico Shunju Shiroyama Hospital, Osaka, Japan.

Introduction: A 50-year-old Japanese man presented with obstructive jaundice. We performed endoscopic retrograde biliary drainage before biliary decompression. CT showed a thickened gallbladder wall with low-density areas and a 35-mm gallstone; the stone was impacted in the gallbladder neck and cystic duct. Read More

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December 2018

Weight control before and during pregnancy for patients with gestational diabetes mellitus.

J Diabetes Investig 2018 Dec 12. Epub 2018 Dec 12.

Department of Endocrinology and Diabetes, Saitama Medical University, Iruma-gun, Saitama, 350-0495, Japan.

Aims/introduction: To examine the associations of pregestational body mass index (BMI) and gestational weight change with birthweight for gestational age in Japanese mothers with gestational diabetes mellitus (GDM).

Materials And Methods: We retrospectively examined the clinical and laboratory characteristics of 101 mothers with GDM (pregestational BMI, mean ± SD: 24.7 ± 5. Read More

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December 2018

Recipient sepsis caused by Lactococcus garvieae contamination of platelets from a donor with colon cancer.

Vox Sang 2018 Dec 12. Epub 2018 Dec 12.

Central Blood Institute, Blood Service Headquarters, Japanese Red Cross Society, Tokyo, Japan.

Lactococcus garvieae is a well-known fish pathogen that has low virulence in humans and is rarely isolated from the blood cultures of endocarditis patients. We describe herein the first reported case of transfusion-transmitted L. garvieae sepsis caused by a contaminated platelet concentrate from a donor who consumed raw octopus before blood donation. Read More

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December 2018

Consecutive influenza surveillance of neuraminidase mutations and neuraminidase inhibitor resistance in Japan.

Influenza Other Respir Viruses 2018 Dec 11. Epub 2018 Dec 11.

Japan Physicians Association, Influenza Study Group, Tokyo, Japan.

Background: The large consumption of neuraminidase (NA) inhibitors (NAIs) for the treatment of influenza virus infections places Japan at risk of becoming the epicenter of the global spread of NAI-resistant viruses.

Objective: To clarify NA amino acid mutations of epidemic influenza viruses in Japan and their related NAI resistance METHODS: A total of 1791 samples, including 396 A/H1N1pdm09, 1117 A/H3N2, and 278 B isolates, were collected to determine of their 50% inhibitory concentration (IC ) values by NAIs (oseltamivir, zanamivir, peramivir, and laninamivir) during the Japanese seasons from 2011-12 to 2016-17. Then, 380 samples including 49 A/H1N1pdm09, 251 A/H3N2, and 80 B isolates, were sequenced for the entire NA genes. Read More

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December 2018

Rupture of perivascular epithelioid cell neoplasm at 34 weeks' gestation: A nonendometriosis case of spontaneous hemoperitoneum in pregnancy.

J Obstet Gynaecol Res 2018 Dec 12. Epub 2018 Dec 12.

Department of Obstetrics and Gynecology, Japanese Red Cross Ishinomaki Hospital, Ishinomaki, Japan.

Spontaneous hemoperitoneum in pregnancy (SHiP) has mainly been discussed in the context of endometriosis. With hormonal changes and enlargement of the uterus during pregnancy, tumors can also increase the chance of rupture and consequent SHiP. We report a case of a 30-year-old primiparous woman presented with sudden-onset intraabdominal hemorrhage at 34 weeks' gestation. Read More

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December 2018

A retrospective multicenter study of carbon-ion radiotherapy for external auditory canal and middle ear carcinomas.

Cancer Med 2018 Dec 8. Epub 2018 Dec 8.

Hospital of the National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Sciences and Technology, Chiba, Japan.

Background: We conducted a retrospective multicenter study to assess the clinical outcomes of carbon-ion radiotherapy (CIRT) for head and neck malignancies (Japan Carbon-Ion Radiation Oncology Study Group [J-CROS] study: 1402 HN). We aimed to evaluate the safety and efficacy of CIRT in patients with external auditory canal (EAC) and middle ear (ME) carcinomas.

Methods: Thirty-one patients treated with CIRT at four Japanese institutions were analyzed. Read More

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December 2018

Acetylcholine spasm provocation test by trans-radial artery and brachial vein approach.

Catheter Cardiovasc Interv 2018 Dec 8. Epub 2018 Dec 8.

Department of Cardiology, Ehime Niihama Prefectural Hospital, Niihama, Ehime, Japan.

Background: Temporary pace maker is necessary because of transient block or bradycardia during the intracoronary acetylcholine spasm provocation tests based on the Japanese Circulation Society guidelines.

Objectives: We examined the feasibility and safety of the acetylcholine spasm provocation test via the radial artery and brachial vein approach.

Methods: We tried to perform the acetylcholine spasm provocation tests in 252 patients via the radial artery and brachial vein approach procedures during 5 years. Read More

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December 2018

Adoption of prophylactic cranial irradiation (PCI) for extensive stage small cell lung cancer (ES-SCLC): a population based outcome study.

Radiat Oncol 2018 Dec 14;13(1):247. Epub 2018 Dec 14.

Division of Radiation Oncology, National Cancer Center Singapore, Singapore, Singapore.

Background: The survival benefit of PCI in ES-SCLC reported by a European randomized trial (RCT) in 2007 was not replicated by a Japanese RCT published in 2017. This study aimed to evaluate the uptake of PCI before and after publication of the European RCT and its association with survival in ES-SCLC.

Methods: We identified eligible patients in the only two Singapore national cancer centres from 2003 to 2010. Read More

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December 2018

Epidemiological association between multiple chemical sensitivity and birth by caesarean section: a nationwide case-control study.

Environ Health 2018 Dec 14;17(1):89. Epub 2018 Dec 14.

Clinical Research Center for Allergy and Rheumatology, National Hospital Organization Sagamihara National Hospital, 18-1 Sakuradai, Minami-ku, Sagamihara, Kanagawa, 252-0392, Japan.

Introduction: Multiple chemical sensitivity (MCS) is characterized by recurrent nonspecific symptoms that are attributed to exposure to trace levels of environmental agents. Although the clinical symptoms of MCS have been described in several studies, the risk factors for this condition remain unclear. Our aim was to clarify the risk factors for MCS and the association between MCS and birth by caesarean section. Read More

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December 2018

Mediating effect of aerobic fitness on the association between physical activity and academic achievement among adolescents: A cross-sectional study in Okinawa, Japan.

J Sports Sci 2018 Dec 14:1-8. Epub 2018 Dec 14.

c Faculty of Education , University of the Ryukyus , Okinawa , Japan.

The purpose of this study was to examine the potential role of aerobic fitness (AF) as a mediator of the association between physical activity (PA) and academic achievement (AA) among Japanese junior high school students. A cross-sectional data was collected from 608 7th grade students enrolled at five public junior high schools in two suburban municipalities in Okinawa, Japan. Self-reported PA was assessed using the Patient-Centred Assessment and Counselling for Exercise plus Nutrition questionnaire. Read More

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December 2018

'The present state and statistical observation of mental patients under home custody', by Kure Shūzō and Kashida Gorō (1918).

Authors:
Akira Hashimoto

Hist Psychiatry 2018 Dec 14:957154X18818045. Epub 2018 Dec 14.

Aichi Prefectural University, Japan.

This text, dealing with the private confinement of the mentally ill at home, or shitaku kanchi, has often been referred to as a 'classic text' in the history of Japanese psychiatry. Shitaku kanchi was one of the most prevalent methods of treating mental disorders in early twentieth-century Japan. Under the guidance of Kure Shūzō (1865-1932), Kure's assistants at Tokyo University inspected a total of 364 rooms of shitaku kanchi across Japan between 1910 and 1916. Read More

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December 2018

Diagnosis using deep-learning artificial intelligence based on the endocytoscopic observation of the esophagus.

Esophagus 2018 Dec 13. Epub 2018 Dec 13.

AI Medical Service Inc., Tokyo, Japan.

Background And Aims: The endocytoscopic system (ECS) helps in virtual realization of histology and can aid in confirming histological diagnosis in vivo. We propose replacing biopsy-based histology for esophageal squamous cell carcinoma (ESCC) by using the ECS. We applied deep-learning artificial intelligence (AI) to analyse ECS images of the esophagus to determine whether AI can support endoscopists for the replacement of biopsy-based histology. Read More

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December 2018

A thermostable trypsin from freshwater fish Japanese dace (Tribolodon hakonensis): a comparison of the primary structures among fish trypsins.

Fish Physiol Biochem 2018 Dec 13. Epub 2018 Dec 13.

Laboratory of Marine Chemical Resource Development, Faculty of Fisheries Sciences, Hokkaido University, Hakodate, Hokkaido, 041-8611, Japan.

Trypsin from Japanese dace (Tribolodon hakonensis) (JD-T) living in freshwater (2-18 °C) was purified. JD-T represented typical fish trypsin characteristics regarding the effects of protease inhibitor, calcium-ion, and pH. For the effect of temperature, JD-T quite resembled to the trypsins from tropical-zone marine fish and freshwater fish (the catfish cultured in Thailand), i. Read More

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December 2018
1 Read

A less invasive surgery using a full-endoscopic system for L5 nerve root compression caused by lumbar foraminal stenosis.

J Spine Surg 2018 Sep;4(3):594-601

Department of Orthopaedics, Iwai Orthopaedic Medical Hospital, Tokyo, Japan.

Background: Percutaneous endoscopic lumbar discectomy (PELD) is a relatively less invasive treatment for lumbar disc herniation (LDH). This study investigated the usefulness of a full-endoscopic system for PELD to treat L5 nerve root compression caused by lumbar foraminal stenosis (L5-LFS).

Methods: Between November 2016 and December 2017, a total of 10 patients with unilateral leg pain due to L5-LFS underwent surgery using a full-endoscopic system for PELD. Read More

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September 2018
2 Reads

Abdominal and Thigh Muscle Attenuation Is Associated With Visceral Fat and Age in Children and Adolescents With Obesity.

Glob Pediatr Health 2018 4;5:2333794X18817121. Epub 2018 Dec 4.

Mie University, Tsu, Mie, Japan.

. This study investigated relationships between adipose tissue deposition within skeletal muscle and morphological and biochemical variables in children with obesity. . Read More

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December 2018

Nurses' and Care Workers' Perception of Care Quality in Japanese Long-Term Care Wards: A Qualitative Descriptive Study.

Glob Qual Nurs Res 2018 Jan-Dec;5:2333393618812189. Epub 2018 Nov 30.

University of Tokyo, Tokyo, Japan.

Despite the growing importance of long-term care for older adults, there has been limited attention to its quality assurance issues in Japan. To start planning the initiation of continuous quality improvement in long-term care hospitals, we explored how nurses and care workers themselves perceived current approaches to quality assurance and improvement on their ward. We interviewed 16 licensed nurses and nine care workers, transcribed and analyzed data using qualitative content analysis techniques, and derived six categories: , and . Read More

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November 2018

Risk stratification of castration-resistant prostate cancer patients treated with cabazitaxel.

Mol Clin Oncol 2018 Dec 19;9(6):683-688. Epub 2018 Sep 19.

Department of Urology, Keio University School of Medicine, Tokyo 160-8582, Japan.

Patient characteristics before administering the first cycle of cabazitaxel for metastatic castration-resistant prostate cancer (mCRPC) were collected to assess prognostic factors for overall survival (OS). Multivariate analysis revealed that prostate-specific antigen (PSA) ≥100 ng/ml prior to cabazitaxel treatment, visceral metastasis, and low absolute monocyte count were independent prognostic indicators for OS. The aim of the present study was to investigate prognostic biomarkers in patients treated with cabazitaxel among Japanese metastatic castration-resistant prostate cancer (mCRPC) patients. Read More

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December 2018

Preoperative inferior vena cava filter implantation to prevent pulmonary fat embolism in a patient showing renal angiomyolipoma extension into the renal vein: A case report and literature review.

J Rural Med 2018 Nov 29;13(2):181-184. Epub 2018 Nov 29.

Department of Urology, JA Toride Medical Center, Japan.

Renal angiomyolipoma without local invasion is usually considered benign entity, however, it may extend into the renal vein or the inferior vena cava. Renal angiomyolipoma with venous extension should be treated; however, surgical complications such as iatrogenic pulmonary fat embolism remain a serious concern. We present a case of a 66-year-old Japanese woman without tuberous sclerosis in whom a right-sided renal tumor was incidentally detected on ultrasonography during a health check-up. Read More

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November 2018

Validity and reliability of the Japanese version of the Rathus assertiveness schedule in day psychiatric care users with schizophrenia.

J Rural Med 2018 Nov 29;13(2):172-176. Epub 2018 Nov 29.

International University of Health and Welfare Graduate School, Japan.

This study aimed to investigate the validity and reliability of the Japanese version of the Rathus assertiveness schedule (J-RAS) in psychiatric day care users with schizophrenia. We examined 715 psychiatric day care users with schizophrenia by conducting the test twice between September 2007 and February 2008 using a questionnaire-based survey. We examined construct validity and used the internal reliability test, split-half method, and test-retest method to examine reliability. Read More

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November 2018

Correlation between job security as motivation and career maturity among Japanese nursing students.

J Rural Med 2018 Nov 29;13(2):168-171. Epub 2018 Nov 29.

Department of Nursing, Faculty of Nursing, Kansai University of Nursing and Health Sciences, Japan.

For nursing students, career maturity -an individual's readiness to cope with career development tasks and make age-appropriate career decisions- is an essential factor influencing their desire to continue the job after qualifying as a nurse. Although job security as motivation to become a nurse might influence the career maturity of nursing students, it has not been demonstrated. In this study I aimed to elucidate the correlation between job security as motivation and career maturity among Japanese nursing students. Read More

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November 2018

Clinicopathological features of T1 colorectal carcinomas with skip lymphovascular invasion.

Oncol Lett 2018 Dec 28;16(6):7264-7270. Epub 2018 Sep 28.

Digestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama 224-8503, Japan.

With recent advances in endoscopic treatment, many T1 colorectal carcinomas (CRCs) are resected endoscopically with a negative margin. However, some lesions exhibit skip lymphovascular invasion (SLVI), which is defined as the discontinuous foci of the tumor cells within the colon wall. The aim of the present study was to reveal the clinicopathological features of T1 CRCs with SLVI and validate the Japanese guidelines regarding SLVI. Read More

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December 2018

The Role of Rumination and Negative Affect in Meaning Making Following Stressful Experiences in a Japanese Sample.

Front Psychol 2018 28;9:2404. Epub 2018 Nov 28.

Faculty of Human Sciences, University of Tsukuba, Tsukuba, Japan.

Stressful experiences can lead to meaning making that is seen as central in adjustment. Although rumination and negative affect are important factors of meaning making, little is known about the mechanisms involved. This study aimed to examine the meaning making process, focusing on the role of intrusive and deliberate rumination and negative affect. Read More

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November 2018

A retrospective analysis of haplo-identical HLA-mismatch hematopoietic transplantation without posttransplantation cyclophosphamide for GVHD prophylaxis in patients with adult T-cell leukemia-lymphoma.

Bone Marrow Transplant 2018 Dec 13. Epub 2018 Dec 13.

Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Science, Fukuoka, Japan.

Currently, allogeneic hematopoietic stem cell transplantation (allo-HCT) is the only available curative modality for patients with adult T-cell leukemia-lymphoma (ATL). When used in conjunction with posttransplantation cyclophosphamide (PTCY) for graft-versus-host disease prophylaxis, allo-HCT from an HLA haplo-identical donor yields promising outcomes for many diseases other than ATL. However, appropriate comparisons with other donor sources, especially cord blood and conventional HLA haplo-identical donors, are needed to validate the safety and efficacy of this modality. Read More

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December 2018
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Kamiuntanto increases prefrontal extracellular serotonin levels and ameliorates depression-like behaviors in mice.

J Pharmacol Sci 2018 Nov 30. Epub 2018 Nov 30.

Laboratory of Functional Biomolecules and Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka 573-0101, Japan. Electronic address:

Kamiuntanto (KUT; Jia Wei Wen Dan Tang in Pinyin) is a traditional Japanese Kampo medicine that is used to treat psychological dysfunction. However, the mechanisms of action of KUT are not understood. To investigate the mechanisms underlying the ameliorative properties of KUT, the effects of KUT on abnormal behaviors of isolation-reared mice and on the prefrontal monoaminergic system were examined. Read More

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November 2018
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