163 results match your criteria JPO: Journal of Prosthetics and Orthotics [Journal]


Prosthetic Foot Selection for Individuals with Lower-Limb Amputation: A Clinical Practice Guideline.

J Prosthet Orthot 2018 Oct 13;30(4):175-180. Epub 2018 Sep 13.

PHILLIP STEVENS, MEd, CPO, JOHN RHEINSTEIN, CP, and SHANE WURDEMAN, PhD, MSPO, CP, are affiliated with Hanger Clinic, Austin, TX.

Introduction: This guideline was developed to present current evidence and to provide associated clinical recommendations on prosthetic foot selection for individuals with lower-limb amputation.

Materials: NA.

Methods: The guideline is based upon the best available evidence as it relates prosthetic foot selection during the provision of definitive lower-limb prostheses. Read More

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October 2018
1 Read

Intellectual Property in the Field of Regenerative Medicine in Japan.

Clin Ther 2018 Nov 24;40(11):1823-1827. Epub 2018 Oct 24.

Incubation Center for Advanced Medical Science, Kyushu University, Fukuoka, Japan; Center for Clinical and Translational Research, Kyushu University Hospital, Fukuoka, Japan.

Purpose: Although most pharmaceutical companies and bio-ventures have not yet created a practical business model or a credible exit thus far, most are expecting potential new business to be derived from regenerative medicine. This article discusses and proposes some ideas regarding a patent strategy for regenerative medicine.

Methods: PubMed literature searches were conducted to identify recent reports relevant to regenerative medicine. Read More

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November 2018

Burnout and Mental Health Stigma Among Juvenile Probation Officers: The Moderating Effect of Participatory Atmosphere.

Adm Policy Ment Health 2018 Nov 3. Epub 2018 Nov 3.

Section of Adolescent Medicine, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA.

Despite high rates of mental health problems among juvenile justice-involved youth, mental health stigma among juvenile probation officers (JPOs) is under-studied. This cross-sectional study examined effects of job burnout and workplace participatory atmosphere on mental health stigma among JPOs across Indiana (n = 226). Participatory atmosphere moderated the relationship between JPO burnout-related cynicism and mental health stigma (interaction β = - 0. Read More

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November 2018

Cell division cycle associated 7 like predicts unfavorable prognosis and promotes invasion in glioma.

Pathol Res Pract 2018 Oct 24. Epub 2018 Oct 24.

Department of Neurosurgery, The First Affiliated Hospital of Xinxiang Medical University, No. 88 Weihui Health Road, Xinxiang 453000, Henan Province, People's Republic of China. Electronic address:

Background: Cell division cycle associated 7 like (CDCA7L) belongs to the JPO protein family, which is recently identified as a target gene of c-Myc and is frequently dysregulated in multiple cancers. This study aimed to explore the clinicpathological value and biological role of CDCA7L in glioma.

Methods: CDCA7L expression in glioma patients was determined using the Oncomine database, and the prognostic role of CDCA7L expression was assessed in a retrospective cohort study. Read More

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October 2018
1 Read

Fearful Attachment Linked to Childhood Abuse, Alexithymia, and Depression in Motor Functional Neurological Disorders.

J Neuropsychiatry Clin Neurosci 2018 Oct 31:appineuropsych18040095. Epub 2018 Oct 31.

From the Department of Neurology, Functional Neurology Research Group, Cognitive Behavioral Neurology Unit, Massachusetts General Hospital, Harvard Medical School, Boston (BW, JPO, RJ, DLP); the Department of Psychiatry, Benson-Henry Institute for Mind Body Medicine, Massachusetts General Hospital, Boston (GLF); and the Department of Psychiatry, Neuropsychiatry Unit, Massachusetts General Hospital, Harvard Medical School, Boston (DLP).

Insecure attachment is a predisposing risk factor for the development of functional neurological disorder (FND). There is limited research investigating connections between attachment styles, other predisposing vulnerabilities, and symptom severity in patients with motor FND. By using a within-group design with prospective data collection, the authors performed univariate tests followed by multivariate linear regressions to investigate neuropsychiatric factors associated with four attachment styles (secure, fearful, preoccupied, and dismissing) among 56 patients with motor FND (mean age=40. Read More

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October 2018
6 Reads

Grip Force Control Using Prosthetic and Anatomical Limbs.

J Prosthet Orthot 2018 Jul;30(3):132-139

Department of Kinesiology, 1600 Holloway Avenue, San Francisco State University, San Francisco, CA.

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Organic Extract of Jacq. Leaf Inhibits Interferon-γ Secretion and Has Bacteriostatic Activity against and .

Evid Based Complement Alternat Med 2018 23;2018:5762368. Epub 2018 Aug 23.

Laboratory of Immunomodulation and New Therapeutical Approaches, Research Centre for Therapeutic Innovation-SuelyGaldino (NUPIT-SG), Federal University of Pernambuco, Recife, PE, Brazil.

Jacq. (Acanthaceae) leaves currently found in the Brazilian north-east are widely used to treat diabetes, menstrual pains, asthma, and other disorders. This work aimed to identify the phytochemical characterization and biological activities of leaf extracts. Read More

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August 2018
4 Reads

Growth-Friendly Surgery Is Effective at Treating Early-Onset Scoliosis Associated With Goldenhar Syndrome.

Spine Deform 2018 May - Jun;6(3):327-333

Growing Spine Foundation, San Diego, CA, USA.

Objective: To evaluate the radiographic results and complications of growth-friendly (GF) surgery in the treatment of early-onset scoliosis (EOS) associated with Goldenhar syndrome.

Background: Goldenhar syndrome has been associated with spinal deformity, which may be progressive. Efficacy and complication rate of GF treatment has not been reported for this population of patients with EOS. Read More

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October 2017

Historical Analysis of Bibliometric Trends in the Journal of Pediatric Orthopaedics With a Particular Focus on Sex.

J Pediatr Orthop 2018 Mar;38(3):e168-e171

Department of Orthopaedic Surgery.

Background: Orthopaedics is the clinical discipline with the lowest percentage of female residents and faculty. Pediatric orthopaedics has a higher percentage of women than other orthopaedic subspecialties. It was the purpose of this study to examine bibliometric trends in the Journal of Pediatric Orthopaedics (JPO) with a specific focus on sex. Read More

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March 2018
10 Reads

JPO Interviews Dr. Charles H. Tweed.

Authors:
Birte Melsen

J Clin Orthod 2017 Sep;51(9):516-519

Section of Orthodontics, Department of Dentistry, Faculty of Health Sciences, Aarhus University, Aarhus C, Denmark; Medizinische Hochschule, Hanover, Germany; Private Practice of Orthodontics in Lübeck, Germany.

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September 2017
1 Read

Evaluation of the bisphosphonate effect on stem cells derived from jaw bone and long bone rabbit models: A pilot study.

Arch Oral Biol 2018 Jan 31;85:178-182. Epub 2017 Oct 31.

Department of Oral and Maxillofacial Surgery, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea; Institute of Foreign Language Studies, Korea University, Seoul, Republic of Korea.

Background And Objective: Bisphosphonates have been widely used and the number of patients experiencing medication-related osteonecrosis of the jaw (MRONJ) has been increasing. This study was designed to evaluate the effect of zoledronate on stem cells derived from different tissues.

Design: Stem cells derived from four different tissues were compared using rabbit models (JPO: periosteum from the jaw bone (mandible), JBM: bone marrow from the jaw bone, LPO: periosteum from long bone (tibia), and LBM: bone marrow from long bone). Read More

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January 2018
3 Reads

Up-skilling associate clinicians in Malawi in emergency obstetric, neonatal care and clinical leadership: the ETATMBA cluster randomised controlled trial.

BMJ Glob Health 2016 7;1(1):e000020. Epub 2016 Jul 7.

Division of Metabolic & Vascular Health, Warwick Medical School, The University of Warwick, Coventry, UK.

Background: The ETATMBA (Enhancing Training And Technology for Mothers and Babies in Africa) project-trained associate clinicians (ACs/clinical officers) as advanced clinical leaders in emergency obstetric and neonatal care. This trial aimed to evaluate the impact of training on obstetric health outcomes in Malawi.

Method: A cluster randomised controlled trial with 14 districts of Malawi (8 intervention, 6 control) as units of randomisation. Read More

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July 2016
24 Reads

Current trends and future perspectives of dental pulp capping materials: A systematic review.

J Biomed Mater Res B Appl Biomater 2018 Apr 31;106(3):1358-1368. Epub 2017 May 31.

DDS, PhD, Associate Professor, Department of Restorative Dentistry, Faculty of Dentistry, Federal University of Pelotas, Pelotas, RS, Brazil.

To systematically review the literature to analyze the current trends and future perspectives of dental pulp capping materials through an analysis of scientific and technological data. This study is reported in accordance with the PRISMA Statement. Nine databases were screened: PubMed (MedLine), Lilacs, IBECS, BBO, Web of Science, Scopus, SciELO, Google Scholar, and The Cochrane Library. Read More

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April 2018
7 Reads

The druggable genome and support for target identification and validation in drug development.

Sci Transl Med 2017 03;9(383)

Farr Institute of Health Informatics, University College London, London WC1E 6BT, U.K.

Target identification (determining the correct drug targets for a disease) and target validation (demonstrating an effect of target perturbation on disease biomarkers and disease end points) are important steps in drug development. Clinically relevant associations of variants in genes encoding drug targets model the effect of modifying the same targets pharmacologically. To delineate drug development (including repurposing) opportunities arising from this paradigm, we connected complex disease- and biomarker-associated loci from genome-wide association studies to an updated set of genes encoding druggable human proteins, to agents with bioactivity against these targets, and, where there were licensed drugs, to clinical indications. Read More

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March 2017
4 Reads

What people want in a prosthetic foot: A focus group study.

J Prosthet Orthot 2016 Oct;28(4):145-151

Department of Rehabilitation Medicine, University of Washington, Seattle WA.

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October 2016
26 Reads

Anterior cruciate ligament reconstruction in skeletally immature patients.

Curr Rev Musculoskelet Med 2016 Dec;9(4):445-453

Orthopedic Center, 300 Longwood Ave, Fegan, 2nd Floor, Boston, MA, 02115, USA.

The management of pediatric patients with an anterior cruciate ligament (ACL) tear can be a challenging endeavor for physicians, athletic trainers, coaches, and parents alike. In particular, the significant longitudinal growth that arises from the physes about the knee creates a unique set of circumstances that must be considered in this patient population. The purpose of this review is to provide a summary of the most recent current literature for the management of skeletally immature patients with an ACL tear. Read More

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December 2016

S100B protein and neuron-specific enolase as predictors of cognitive dysfunction after coronary artery bypass graft surgery: A prospective observational study.

Eur J Anaesthesiol 2016 09;33(9):681-9

From the Department of Anaesthesia and Surgical Intensive Care, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HCFMUSP), São Paulo (FPS, LSSV, KOP, SPZ, DAO, JOCA, MJCC); Department of Anaesthesia and Perioperative Medicine, Division of Anaesthesia, Hospital de Clinicas de Porto Alegre (HCPA), Federal University of Rio Grande do Sul (UFRGS) (APS); Department of Surgery, Federal University of Health Sciences of Porto Alegre (UFCSPA) (APS); Department of Biochemistry, Institute of Health Sciences (ICBS), Federal University of Rio Grande do Sul (UFRGS), Porto Alegre (APS, LVP, DOS); Laboratório de Neurociências Clinicas, Programa de Pós-graduação em Saúde e Comportamento, Centro de Ciências da Vida e da Saúde e Hospital Universitário São Francisco de Paula, Universidade Católica de Pelotas, Pelotas (JPO, CDW); and Brain Institute, Federal University of Rio Grande do Norte (UFRN), Natal, Brazil (ABLT).

Background: Postoperative cognitive dysfunction (POCD) may be related to the systemic inflammatory response and an increase in serum markers of brain injury such as S100B protein and neuron-specific enolase (NSE).

Objective: The study aims to evaluate the association between POCD and serum levels of S100B and NSE after coronary artery bypass grafting surgery (CABG).

Design: Prospective observational study. Read More

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September 2016
12 Reads

November 2015: patent term extension: the Supreme Court of Japan gave an answer to the question and the JPO now has to prepare new examination guidelines.

Pharm Pat Anal 2016 May 18;5(3):155-6. Epub 2016 Apr 18.

Shusaku·Yamamoto, 17th Floor, Grand Front Osaka Tower, C 3-1 Ofuka-cho, Kita-ku, Japan.

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May 2016
2 Reads

A Data Preparation Methodology in Data Mining Applied to Mortality Population Databases.

J Med Syst 2015 Nov 18;39(11):152. Epub 2015 Sep 18.

Tecnológico Nacional de México / CENIDET, Interior Internado Palmira s/n, Palmira, 62490, Cuernavaca, Morelos, Mexico.

It is known that the data preparation phase is the most time consuming in the data mining process, using up to 50% or up to 70% of the total project time. Currently, data mining methodologies are of general purpose and one of their limitations is that they do not provide a guide about what particular task to develop in a specific domain. This paper shows a new data preparation methodology oriented to the epidemiological domain in which we have identified two sets of tasks: General Data Preparation and Specific Data Preparation. Read More

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November 2015

Activity, assay and target data curation and quality in the ChEMBL database.

J Comput Aided Mol Des 2015 Sep 23;29(9):885-96. Epub 2015 Jul 23.

European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SD, UK.

The emergence of a number of publicly available bioactivity databases, such as ChEMBL, PubChem BioAssay and BindingDB, has raised awareness about the topics of data curation, quality and integrity. Here we provide an overview and discussion of the current and future approaches to activity, assay and target data curation of the ChEMBL database. This curation process involves several manual and automated steps and aims to: (1) maximise data accessibility and comparability; (2) improve data integrity and flag outliers, ambiguities and potential errors; and (3) add further curated annotations and mappings thus increasing the usefulness and accuracy of the ChEMBL data for all users and modellers in particular. Read More

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September 2015

Probation Intensity, Self-Reported Offending, and Psychopathy in Juveniles on Probation for Serious Offenses.

J Am Acad Psychiatry Law 2015 Jun;43(2):191-200

Dr. Wagoner is a Staff Psychiatrist, Saint Simon's By-the-Sea Hospital, St. Simon's Island, GA. Ms. Schubert is a Research Program Administrator and Dr. Mulvey is a Professor of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA. This project was completed while Dr. Wagoner was a psychiatry resident at Western Psychiatric Institute and Clinic. The project described was supported by funds from the following: Office of Juvenile Justice and Delinquency Prevention (2007-MU-FX-0002), National Institute of Justice (2008-IJ-CX-0023), the John D. and Catherine T. MacArthur Foundation, the William T. Grant Foundation, the Robert Wood Johnson Foundation, the William Penn Foundation, the Centers for Disease Control and Prevention, the National Institute on Drug Abuse (R01DA019697), the Pennsylvania Commission on Crime and Delinquency, and the Arizona Governor's Justice Commission.

This study examines the relationship between level of supervision by the juvenile probation officers (JPO) and an adolescent's offending, considering the characteristics of juvenile offenders (specifically, level of psychopathy). Data are taken from the Pathways to Desistance Study on a subset of 859 juvenile offenders. We found that the level of probation officer supervision was not consistently related to the juvenile's risk of recidivism, and level of supervision did not affect self-reported offending. Read More

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June 2015
1 Read

Variations in the GLA gene correlate with globotriaosylceramide and globotriaosylsphingosine analog levels in urine and plasma.

Clin Chim Acta 2015 Jul 9;447:96-104. Epub 2015 Jun 9.

Department of Genetics, Faculty of Medicine, University of Porto, Alameda Hernâni Monteiro, 4200-319 Porto, Portugal; Medical Genetics Outpatient Clinic, São João Hospital Centre, Alameda Hernâni Monteiro, 4200-319 Porto, Portugal. Electronic address:

Recent data have shown that lyso-Gb3, the deacylated derivative of globotriaosylceramide (Gb3), is possibly involved in the pathogenesis of Fabry disease (FD) and might be a clinically useful biomarker of its metabolic load. To test this hypothesis, we assayed Gb3 and lyso-Gb3 and related analogs in plasma and/or urine samples of 12 clinically well-characterized subjects carrying several different GLA variant alleles associated with a wide range of residual α-galactosidase A activities. Urinary Gb3 was measured by HPLC-MS/MS; plasma and urinary lyso-Gb3 and related analogs were measured by UPLC-MS/MS. Read More

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July 2015
11 Reads

The relationship between target-class and the physicochemical properties of antibacterial drugs.

Bioorg Med Chem 2015 Aug 28;23(16):5218-24. Epub 2015 Apr 28.

European Molecular Biology Laboratory-European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, CB10 1SD, United Kingdom. Electronic address:

The discovery of novel mechanism of action (MOA) antibacterials has been associated with the concept that antibacterial drugs occupy a differentiated region of physicochemical space compared to human-targeted drugs. With, in broad terms, antibacterials having higher molecular weight, lower logP and higher polar surface area (PSA). By analysing the physicochemical properties of about 1700 approved drugs listed in the ChEMBL database, we show, that antibacterials for whose targets are riboproteins (i. Read More

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Recommendations for initiation and cessation of enzyme replacement therapy in patients with Fabry disease: the European Fabry Working Group consensus document.

Orphanet J Rare Dis 2015 Mar 27;10:36. Epub 2015 Mar 27.

Department of Internal Medicine, Division Endocrinology and Metabolism, Academic Medical Center, PO Box 22660, Amsterdam, 1100 DD, The Netherlands.

Introduction: Fabry disease (FD) is a lysosomal storage disorder resulting in progressive nervous system, kidney and heart disease. Enzyme replacement therapy (ERT) may halt or attenuate disease progression. Since administration is burdensome and expensive, appropriate use is mandatory. Read More

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March 2015
81 Reads
27 Citations
3.360 Impact Factor

ChEMBL web services: streamlining access to drug discovery data and utilities.

Nucleic Acids Res 2015 Jul 16;43(W1):W612-20. Epub 2015 Apr 16.

European Molecular Biology Laboratory - European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK

ChEMBL is now a well-established resource in the fields of drug discovery and medicinal chemistry research. The ChEMBL database curates and stores standardized bioactivity, molecule, target and drug data extracted from multiple sources, including the primary medicinal chemistry literature. Programmatic access to ChEMBL data has been improved by a recent update to the ChEMBL web services (version 2. Read More

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July 2015
4 Reads

The effect of different graphical and numerical likelihood formats on perception of likelihood and choice.

Med Decis Making 2015 05 13;35(4):487-500. Epub 2015 Mar 13.

EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands (JPO, DRMT).

Background: Quantitative risk information plays an important role in decision making about health. This study focuses on commonly used numerical and graphical formats and examines their effect on perception of different likelihoods and choice preferences.

Methods: An experimental study was conducted with 192 participants, who evaluated 2 sets of 4 lotteries. Read More

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May 2015
8 Reads

Functional and psychosocial status of Haitians who became users of lower extremity prostheses as a result of the 2010 earthquake.

J Prosthet Orthot 2014 Oct;26(4):177-182

Florida International University, Department of Social Work.

The January 12, 2010 earthquake devastated Port-Au-Prince, the capital of the Republic of Haiti, and its surroundings. Among the 300,000 injured, 1,200 to 1,500 people underwent traumatic /surgical amputations. The purpose of this study was to describe the functional and psychosocial impact of prostheses users who suffered a traumatic lower-limb amputation after the earthquake of 2010 in Haiti. Read More

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October 2014
13 Reads

The Quality of Randomized Controlled Trials in Pediatric Orthopaedics: Are We Improving?

J Pediatr Orthop 2015 Jul-Aug;35(5):536-45

*Hospital for Special Surgery, Weill Cornell Medical College, New York, NY †George Washington University Medical School, Washington, DC ‡Stollery Children's Hospital, Edmonton, AB §British Columbia Children's Hospital, University of British Columbia, Vancouver, BC, Canada.

Purpose: The quality of randomized controlled trials (RCTs) in orthopaedics is a topic of considerable importance, as RCTs play a major role in guiding clinical practice. The quality of RCTs published between 1995 and 2005 has previously been documented. The purpose of the current study was to assess and describe the quality of pediatric orthopaedic RCTs published from 2005 to 2012, by identifying study characteristics associated with higher quality and outlining areas for improvement. Read More

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December 2015
1 Read

The alpha-galactosidase A p.Arg118Cys variant does not cause a Fabry disease phenotype: data from individual patients and family studies.

Mol Genet Metab 2015 Feb 9;114(2):248-58. Epub 2014 Nov 9.

Departamento de Genética, Faculdade de Medicina, Universidade do Porto, 4200-319 Porto, Portugal; Serviço de Nefrologia, Centro Hospitalar de São João, 4200-319 Porto, Portugal; Consulta de Genética Médica, Centro Hospitalar de São João, 4200-319 Porto, Portugal. Electronic address:

Lysosomal α-galactosidase A (α-Gal) is the enzyme deficient in Fabry disease (FD), an X-linked glycosphingolipidosis caused by pathogenic mutations affecting the GLA gene. The early-onset, multi-systemic FD classical phenotype is associated with absent or severe enzyme deficiency, as measured by in vitro assays, but patients with higher levels of residual α-Gal activity may have later-onset, more organ-restricted clinical presentations. A change in the codon 118 of the wild-type α-Gal sequence, replacing basic arginine by a potentially sulfhydryl-binding cysteine residue - GLA p. Read More

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February 2015
20 Reads
10 Citations
2.620 Impact Factor

Levels of Evidence in the Journal of Pediatric Orthopaedics: Update and Comparison to the Journal of Bone and Joint Surgery.

J Pediatr Orthop 2015 Oct-Nov;35(7):779-81

University of Tennessee-Campbell Clinic, Memphis, TN.

Background: Periodic review of the published research in pediatric orthopaedics is helpful to evaluate the state of scientific methodology. The purpose of this paper was to review the levels of evidence (LOE) and types of evidence (TOE) published in the Journal of Pediatric Orthopaedics (JPO) from 2009 to 2013 and to compare the percentage of articles with each LOE to pediatric orthopaedic articles published in the Journal of Bone and Joint Surgery-American Volume (JBJS) during the same time.

Methods: All articles published in JPO from January 1, 2009, to December 31, 2013, were reviewed. Read More

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May 2016
2 Reads

Classifying cerebral palsy: are we nearly there?

J Pediatr Orthop 2015 Mar;35(2):162-6

*Department of Orthopaedic Surgery, The Royal Children's Hospital ‡School of Allied and Public Health, Australian Catholic University, Melbourne †Faculty of Medicine, The University of Melbourne, Carlton §Murdoch Childrens Research Institute, Parkville, Vic., Australia.

Background: Cerebral palsy (CP) is the most common cause of physical disability in childhood in developed countries and encompasses a wide range of clinical phenotypes. Classification of CP according to movement disorder or topographical distribution is widely used. However, these classifications are not reliable nor do they accurately predict musculoskeletal pathology. Read More

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March 2015
5 Reads

Training Strategies for Mitigating the Effect of Proportional Control on Classification in Pattern Recognition Based Myoelectric Control.

J Prosthet Orthot 2013 Apr;25(2):76-83

Institute of Biomedical Engineering University of New Brunswick, Fredericton, NB, Canada.

The performance of pattern recognition based myoelectric control has seen significant interest in the research community for many years. Due to a recent surge in the development of dexterous prosthetic devices, determining the clinical viability of multifunction myoelectric control has become paramount. Several factors contribute to differences between offline classification accuracy and clinical usability, but the overriding theme is that the variability of the elicited patterns increases greatly during functional use. Read More

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April 2013
10 Reads

A Training Strategy for Learning Pattern Recognition Control for Myoelectric Prostheses.

J Prosthet Orthot 2013 Jan;25(1):30-41

Johns Hopkins University, Department of Biomedical Engineering.

Pattern recognition-based control of myoelectric prostheses offers amputees a natural, intuitive way of controlling the increasing functionality of modern myoelectric prostheses. While this approach to prosthesis control is certainly attractive, it is a significant departure from existing control methods. The transition from the more traditional methods of direct or proportional control to pattern recognition-based control presents a training challenge that will be unique to each amputee. Read More

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January 2013
4 Reads

Inhibition of sebum production and Propionibacterium acnes lipase activity by fullerenol, a novel polyhydroxylated fullerene: potential as a therapeutic reagent for acne.

J Cosmet Sci 2012 Jul-Aug;63(4):259-65

Department of Regenerative Dermatology, Graduate School of Medicine, Osaka University, 2-2, G2 Yamadaoka, Suita, Osaka 565-0871, Japan.

Oxidative stress plays a major role in acne formation; this suggests that oxygen-radical scavengers could be potential therapeutic agents. Fullerenol C60(OH)44, a recently developed polyhydroxylated fullerene, is a spherical carbon molecule that has many hydroxyl groups capable of potent radical-scavenging activity. We have investigated its inhibitory effects in vitro on sebum production in hamster sebocytes and in Propionibacterium acnes lipase activity. Read More

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January 2013
16 Reads

Probation officers' perceptions of youths' risk of reoffending and use of risk assessment in case management.

Behav Sci Law 2012 Jul-Aug;30(4):487-505. Epub 2012 Jun 28.

University of Massachusetts Medical School, Department of Psychiatry, 55 Lake Avenue North, WSH 8B, Worcester, MA 01655, USA.

Juvenile probation officers (JPOs) are required to make numerous decisions about the case management of young offenders on a daily basis. This multi-site study examined JPOs' (N=64) perceptions of the typical youth's risk of reoffending before implementation of a risk/needs assessment (RNA) tool, and their self-reported, case management decision-making after implementation of an RNA tool. Results indicated that JPOs tended to overestimate the likely base rates of reoffending while RNA tool estimates were more accurate. Read More

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January 2013
1 Read

Field reliability of the SAVRY with juvenile probation officers: Implications for training.

Law Hum Behav 2012 Jun;36(3):225-36

Center for Mental Health Services Research, Department of Psychiatry, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA.

Two complimentary studies were conducted to investigate the inter-rater reliability and performance of juvenile justice personnel when conducting the Structured Assessment of Violence Risk for Youth (SAVRY). Study 1 reports the performance on four standardized vignettes of 408 juvenile probation officers (JPOs) and social workers rating the SAVRY as part of their training. JPOs had high agreement with the expert consensus on the SAVRY rating of overall risk and total scores, but those trained by a peer master trainer outperformed those trained by an expert. Read More

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June 2012
15 Reads

Patient training for functional use of pattern recognition-controlled prostheses.

J Prosthet Orthot 2012 Apr;24(2):56-64

Center for Bionic Medicine, Rehabilitation Institute of Chicago, Chicago, IL.

Pattern recognition control systems have the potential to provide better, more reliable myoelectric prosthesis control for individuals with an upper-limb amputation. However, proper patient training is essential. We begin user training by teaching the concepts of pattern recognition control and progress to teaching how to control, use, and maintain prostheses with one or many degrees of freedom. Read More

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April 2012
12 Reads

The levels of evidence in pediatric orthopaedic journals: where are we now?

J Pediatr Orthop 2011 Sep;31(6):721-5

Department of Orthopaedics, British Columbia Children's Hospital, British Columbia, Canada.

Background: In recent years, it has become common to publish a level of evidence grading for orthopaedic journal publications. Our primary research question is: is there an improvement in levels of evidence of articles published in pediatric orthopaedic journals over time? In addition, what is the current status of levels of evidence in pediatric orthopaedic journals?

Methods: All articles in Journal of Pediatric Orthopaedics-A (JPO-A) and Journal of Pediatric Orthopaedics-B (JPO-B) for 2001, 2002, 2007, and 2008 and those in Journal of Children's Orthopaedics (JCO) for 2007 and 2008, were collected by an independent reviewer. Of the 1,039 articles identified, animal, cadaveric and basic science studies, expert opinion and review articles were excluded. Read More

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September 2011
1 Read

Virtual reality environment for simulating tasks with a myoelectric prosthesis: an assessment and training tool.

J Prosthet Orthot 2011 Apr;23(2):89-94

Department of Biomedical Engineering, Case Western Reserve University (Cleveland, OH).

Intuitively and efficiently controlling multiple degrees of freedom is a major hurdle in the field of upper limb prosthetics. A virtual reality myoelectric transhumeral prosthesis simulator has been developed for cost-effectively testing novel control algorithms and devices. The system acquires EMG commands and residual limb kinematics, simulates the prosthesis dynamics, and displays the combined residual limb and prosthesis movements in a virtual reality environment that includes force-based interactions with virtual objects. Read More

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April 2011
11 Reads

Psychometric comparison of standard and computerized administration of the Alzheimer’s Disease Assessment Scale: Cognitive Subscale (ADASCog).

Curr Alzheimer Res 2011 May;8(3):323-8

NeuroComp Systems, Inc., Irvine, CA, USA.

Background: The Alzheimer’s Disease Assessment Scale – Cognitive Subscale (ADAS-Cog) has become the de facto gold standard for assessing the efficacy of anti-dementia treatments. However, manual administration of the ADAS-Cog is subject to procedural inconsistencies, including scoring and transcription errors, which can introduce unwanted variance and compromise data quality within and across sites and trials. To address such concerns, a computerized version was developed that integrates, rather than replaces, the examiner, standardizes administration, and uses electronic data capture at the point of patient contact. Read More

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Estrogen stimulates proliferation and differentiation of neural stem/progenitor cells through different signal transduction pathways.

Int J Mol Sci 2010 Oct 22;11(10):4114-23. Epub 2010 Oct 22.

Laboratory of Molecular Biology, Department of Biofunctional Analysis, Gifu Pharmaceutical University, Gifu, Japan; E-Mails: (M.O.); (A.M.); (S.F.).

Our previous study indicated that both 17β-estradiol (E2), known to be an endogenous estrogen, and bisphenol A (BPA), known to be a xenoestrogen, could positively influence the proliferation or differentiation of neural stem/progenitor cells (NS/PCs). The aim of the present study was to identify the signal transduction pathways for estrogenic activities promoting proliferation and differentiation of NS/PCs via well known nuclear estrogen receptors (ERs) or putative membrane-associated ERs. NS/PCs were cultured from the telencephalon of 15-day-old rat embryos. Read More

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October 2010
1 Read

Ankle-Foot Orthoses: Proprioceptive Inputs and Balance Implications.

J Prosthet Orthot 2010;22(4 Suppl):34-37

Marianjoy Rehabilitation Hospital, Wheaton, Illinois.

Individuals with a loss of sensation in the lower limbs frequently experience postural instability, altered gait patterns, and an increased risk of falling culminating in a decreased quality of life. Previous studies have documented that using ankle-foot orthoses (AFOs) help such individuals to maintain their balance. This study was conducted to investigate whether somatosensory cues delivered to the intact tissues of the lower limbs above the ankle joints enhance the control of posture in individuals with peripheral neuropathy. Read More

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January 2010
6 Reads

[Specializing doctors with African CUAMM: the JPO program].

Authors:
A Capretta

Minerva Pediatr 2009 Dec;61(6):612

Medici con l'Africa CUAMM, Padova.

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December 2009

Nano Mapper: an Internet knowledge mapping system for nanotechnology development.

J Nanopart Res 2009 Apr 22;11(3):529-552. Epub 2008 Oct 22.

Nanotechnology research has experienced rapid growth in recent years. Advances in information technology enable efficient investigation of publications, their contents, and relationships for large sets of nanotechnology-related documents in order to assess the status of the field. This paper presents the development of a new knowledge mapping system, called Nano Mapper (http://nanomapper. Read More

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April 2009
4 Reads

Effect of single-nucleotide polymorphisms of the 5' untranslated region of the human α-galactosidase gene on enzyme activity, and their frequencies in Portuguese caucasians.

J Inherit Metab Dis 2008 Dec 3;31 Suppl 2:S247-53. Epub 2008 Nov 3.

Serviço de Genética, Faculdade de Medicina, Universidade do Porto, Alameda Hernâni Monteiro, 4200-319, Porto, Portugal.

Background: The α-galactosidase gene (GLA) has three single-nucleotide polymorphisms in the 5' untranslated region of exon 1, respectively g.1150G>A, g.1168G>A, g. Read More

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December 2008

The g.1170C>T polymorphism of the 5' untranslated region of the human alpha-galactosidase gene is associated with decreased enzyme expression--evidence from a family study.

J Inherit Metab Dis 2008 Dec 3;31 Suppl 2:S405-13. Epub 2008 Nov 3.

Department of Medical Genetics, Faculty of Medicine, University of Porto, Alameda Hernâni Monteiro, 4200-319, Porto, Portugal.

Subnormal leukocyte α-galactosidase (α-Gal) activity was found during evaluation of an adolescent male with cryptogenic cerebrovascular small-vessel disease. The only molecular abnormality found was the g.1170C>T single-nucleotide polymorphism (SNP) in the 5' untranslated region of exon 1 in the α-Gal gene (GLA). Read More

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December 2008

Comparison of Rectified and Unrectified Sockets for Transtibial Amputees.

J Prosthet Orthot 2008 ;18(1):1-7

Human Performance Laboratory, Department of Neurosurgery, Washington University Medical School, St. Louis, MO.

The current method for fabricating prosthetic sockets is to modify a positive mold to account for the non-homogeneity of the residual limb to tolerate load (i.e., rectified socket). Read More

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January 2008
9 Reads

Splenomegaly, hypersplenism and peripheral blood cytopaenias in patients with classical Anderson-Fabry disease.

Virchows Arch 2008 Sep 2;453(3):291-300. Epub 2008 Sep 2.

Department of Medical Genetics, Faculty of Medicine, Porto, Portugal.

A 39-year-old male with classical Anderson-Fabry disease (AFD) and long-standing idiopathic splenomegaly, who had been on haemodialysis since the age of 24, was splenectomised for symptomatic pancytopaenia. Spleen enlargement was first noted at clinical presentation, at age 16, but despite thorough investigation its cause remained unclear. Anaemia, leukopaenia and thrombocytopaenia were first observed a few years thereafter, but well before the start of dialytic treatment. Read More

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September 2008
1 Read