104 results match your criteria JPMA. The Journal of the Pakistan Medical Association[Journal]
J Pak Med Assoc 2018 Sep;68(9):1358-1362
Internal Medicine Nursing, Faculty of Health Science, Sakarya University, Serdivan, Turkey.
Objective: To evaluate fat phobia levels and attitudes towards obese person among university students to determine their correlation with healthy lifestyle behaviour.
Methods: The knowledge, attitude and practice study was conducted at Sakarya University, Turkey, between May and December 2015, and comprised students of either gender. Data was collected by using the socio-demographic form, fat phobia scale, attitudes toward obese persons scale, and health-promoting lifestyle profile II scale. Read More
J Pak Med Assoc 2018 Sep;68(9):1350-1357
Riphah International University, slamic International Medical College, Rawalpindi.
Objective: To explore the awareness of faculty and medical students about students' roles with respect to patient safety and to define the domains that should be made a part of undergraduate curriculum.
Methods: The descriptive exploratory qualitative research was conducted from December 2016 to March 2017 at Islamic International Medical College, Rawalpindi, Pakistan, and comprised faculty members and final year medical students. World Health Organisation patient safety curriculum guideline for undergraduate medical schools was taken as the reference. Read More
J Pak Med Assoc 2018 Sep;68(9):1339-1344
Section of Neurology, Department of Internal Medicine, Aga Khan University Hospital Karachi.
Objective: To assess the time in therapeutic range in patients on warfarin anti-coagulation therapy.
Methods: The retrospective chart review was conducted at Aga Khan University Hospital, Karachi, and comprised data of patients having undergone anti-coagulation with warfarin from January 2013 to April 2015. To determine the mean time in therapeutic range, Rosendaal method was used. Read More
J Pak Med Assoc 2018 Sep;68(9):1334-1338
Shaheed Zulfiqar Ali Bhutto Medical University, PIMS, Islamabad.
Objective: To compare the frequency of pain in root canal treatment using sodium hypochlorite and chlorhexidine as root canal irrigants.
Methods: The cross-sectional study was carried out from January to June 2016 at the Pakistan Institute of Medical Sciences (PIMS), Islamabad, Pakistan, and comprised patients aged 18-40 years with irreversible pulpitis involving a posterior tooth. The patients were divided into two equal groups, with Group-I receiving 2% chlorhexidine, and Group-II receiving 5. Read More
J Pak Med Assoc 2018 Sep;68(9):1327-1333
Institute of Physiotherapy and Rehabilitation Sciences, Peoples University of Medical & Health Sciences for Women, Nawabshah, Sindh, Pakistan.
Objective: To determine the factors associated with participation of Pakistani female students in organised sports at a university in a rural setting in Pakistan.
Methods: This cross-sectional study was conducted during March and April 2017 at the Peoples University of Medical & Health Sciences for Women, Nawabshah in the Sindh province of Pakistan, and comprised undergraduate female students who got injured during the "Sports Week" organized at the university and visited the on-site physiotherapy camp. Data collection tools included physical activity and leisure motivation scale, sport motivation scale, and athlete fear avoidance questionnaire. Read More
J Pak Med Assoc 2018 Sep;68(9):1321-1326
Emergecy Service, Bandirma State Hospital, Balikesir, Turkey.
Objective: Sepsis is the leading disease that is diagnosed late and still has a mortal course in emergency departments. The primary factors that will reduce both morbidity and mortality are early diagnosis and an early treatment approach. Therefore, in this study, P-selectin and MCP1 levels, which are known to be markers of inflammation, were examined in patients being followed up in intensive care. Read More
J Pak Med Assoc 2018 Sep;68(9):1316-1320
Rawalpindi Medical University, Rawalpindi, Pakistan.
Objective: To determine the frequency of reduction of pain in symptomatic knee osteoarthritis by using combination injections.
Methods: The experimental study was conducted from January 1, 2010, to December 31, 2016,at Al-Noor Surgery Hospital, Chakwal, Pakistan, and comprised patients suffering from symptomatic knee osteoarthritis. All patients were injected intra-articularly and peri-articularily with a combination of streptomycin, kenacort and lidocaine. Read More
J Pak Med Assoc 2018 Sep;68(9):1304-1309
Sanofi-Aventis Pakistan Ltd.
Objective: To ascertain the effectiveness of implementing the American Diabetes Association/European Association for the Study of Diabetes 2009 consensus algorithm in achieving glycaemic control in patients with type 2 diabetes.
Methods: The prospective, observational, open label, product registry was conducted at 38 sites across 7 cities in Pakistan between July 2011 and February 2014. Uncontrolled type 2 diabetes patients were either initiated on or switched to insulin glargine from other basal insulin. Read More
J Pak Med Assoc 2018 Sep;68(9):1300-1303
Ameer ud Din Medical College, PGMI, Lahore.
Objective: This study was conducted to determine the prevalence of trachoma among children of age one month to 15 years.
Methods: Community based cross sectional study was conducted in district Dera Ghazi Khan from January to December 2014. The simple random sampling technique was employed. Read More
J Pak Med Assoc 2018 Sep;68(9):1295-1299
Akhter Saeed Trust Teaching Hospital, Lahore.
Objective: To assess the effectiveness of clarithromycin based standard triple therapy verses levofloxacin based first line therapy against Helicobacter pylori infection.
Methods: This prospective observational study was performed at Akhter Saeed Trust Teaching Hospital, Lahore, from May 2016 to 31st May 2017 and comprised of all patients with positive H. pylori, confirmed by gastroscopic biopsy; fulfill the inclusion criteria of this study. Read More
Gan To Kagaku Ryoho 2018 Sep;45(9):1259-1277
UICC-Asia Regional Office(UICC-ARO)successfully convened a fruitful Multi-stakeholder Dialogue at United Nations University in Aoyama, Tokyo, which brought together parliamentarians, representatives ofthe WHO and Japanese government agencies and NGOs, senior executives ofpharmaceutical and other companies, and leading members ofJapan 's cancer research community. This meeting provided a valuable opportunity for stakeholders from all sectors of society to discuss ways in which Japan can develop a multi-sectoral approach that will promote access to cancer care and support initiatives for UHC for cancer in Asia. UICC-ARO Director Hideyuki Akaza and Haruhiko Hirate(Chair of International Affairs Committee, JPMA) co-chaired the meeting. Read More
Regul Toxicol Pharmacol 2018 Nov 14;99:98-104. Epub 2018 Sep 14.
Non-Clinical Evaluation Expert Committee ERA Team, Drug Evaluation Committee, The Japan Pharmaceutical Manufacturers Association (JPMA), Tokyo, Japan; Research Division, Chugai Pharmaceutical Co., Ltd., 1-135, Komakado, Gotemba, Shizuoka, 412-8513, Japan.
The distribution of active pharmaceutical ingredients (APIs) in prescription medicines for human consumption in Japan was estimated using the public database of the National Database of Health Insurance Claims and Specific Health Checkups of Japan (NDB). From the latest NDB, 2058 APIs were identified, and the prescription weight exceeded 1 tonne/year for 711 APIs. Of these, 298 APIs were selected for further analysis after removing 413 APIs that were not covered by current environmental risk assessment (ERA) directives or were combination products. Read More
J Pak Med Assoc 2017 Sep;67(9):1428-1431
Independent Consultant, Karachi.
Assessment of research articles in terms of study designs used, statistical tests applied and the use of statistical analysis programmes help determine research activity profile and trends in the country. In this descriptive study, all original articles published by Journal of Pakistan Medical Association (JPMA) and Journal of the College of Physicians and Surgeons Pakistan (JCPSP), in the year 2015 were reviewed in terms of study designs used, application of statistical tests, and the use of statistical analysis programmes. JPMA and JCPSP published 192 and 128 original articles, respectively, in the year 2015. Read More
J Mol Biol 2017 Oct 31;429(20):3113-3120. Epub 2017 Aug 31.
School of Life Sciences, Tsinghua University, Beijing 100084, China; Applied Physics Program, Rice University, Houston, TX 77005, United States; Department of Bioengineering, Rice University, Houston, TX 77005, United States; Verna and Marrs Mclean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, United States. Electronic address:
We report a new distance- and orientation-dependent, all-atom statistical potential derived from side-chain packing, named OPUS-DOSP, for protein structure modeling. The framework of OPUS-DOSP is based on OPUS-PSP, previously developed by us [JMB (2008), 376, 288-301], with refinement and new features. In particular, distance or orientation contribution is considered depending on the range of contact distance. Read More
J Pak Med Assoc 2017 Apr;67(4):513-520
College of Medicine, Princess Nourah Bint Abdulrahaman University. High Institute of Public Health, Alexandria University.
Objective: To evaluate the effectiveness of health education programme on the knowledge of human papilloma virus among female medical students.
Methods: This quasi-experimental study was conducted in 2014 at the Princess Nourah bint Abulrahman University, Riyadh, Saudi Arabia, and comprised female medical students. An intervention programme was implemented in the form of lectures, videos, posters, etc. Read More
J Pharmacol Toxicol Methods 2017 May - Jun;85:73-81. Epub 2017 Feb 3.
Non-Clinical Evaluation Expert Committee, Drug Evaluation Committee, Japan Pharmaceutical Manufacturers Association (JPMA), 2-3-11 Nihonbashi-Honcho, Chuo-ku, Tokyo 103-0023, Japan; Consortium for Safety Assessment using Human iPS Cells (CSAHi), Japan(1); Biopharmaceutical Assessment Core Function Unit, Medicine Development Center, Eisai Co., Ltd., 5-1-3 Tokodai, Tsukuba, Ibaraki 300-2635, Japan.
Introduction: The use of multi-electrode arrays (MEA) in combination with human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) provides a promising method to predict comprehensive cardiotoxicity, including drug-induced QT prolongation and arrhythmia. We previously demonstrated that MEA in combination with hiPSC-CMs could provide a generalizable platform by using 7 reference drugs at 10 testing facilities. Using this approach, we evaluated responses to reference drugs that modulate a range of cardiac ion currents and have a range of arrhythmogenic effects. Read More
J Pak Med Assoc 2017 02;67(2):154-155
Member, Editorial Board, JPMA, Karachi / Independent Consultant, Karachi
Ther Innov Regul Sci 2017 Jan 27;51(1):9-10. Epub 2016 Sep 27.
3 RAD-AR Council, Tokyo, Japan.
The founding industry members (European Federation of Pharmaceutical Industries and Associations [EFPIA], Japanese Pharmaceutical Manufacturers Association [JPMA], and Pharmaceutical Research and Manufacturers of America [PhRMA]) of the International Council for Harmonisation (ICH) have a 25-year track record of the contribution to ICH. Given that further globalization of ICH is expected, we should value this legacy and maintain the current ICH culture and its principles of "benefit to the patients first" and "science-based approach," through which industry members would ensure transparency and objectivity in their ICH activities. In order to maintain and develop the culture of the ICH and its current momentum, a 2-way approach is important: (1) sharing common views through dialogues among leaders of each industry association, such as through the Industry Executive Council, and (2) spreading the values through grassroots activities involving wider stakeholders in global forums such as DIA, as platforms for sharing the knowledge, views, and culture of ICH across the globe. Read More
J Pak Med Assoc 2016 11;66(11):1500
Section Head of Pulmonary and Critical Care Medicine, Aga Khan University, Karachi.
Ther Innov Regul Sci 2016 Nov 10;50(6):846-852. Epub 2016 Jul 10.
2 Data Science Expert Committee, Japan Pharmaceutical Manufacturers Association, Tokyo, Japan.
Background: This study provides the results of a survey on the current practice of multiplicity adjustment and sample size calculation in multi-arm clinical trials.
Methods: The survey was aimed at members of the Japan Pharmaceutical Manufacturers Association (JPMA) and was conducted in 2015.
Results: Of the 66 JPMA member companies, effective responses were obtained on 151 trials from 33 companies based in Japan and 11 companies based in other countries. Read More
J Pharmacol Toxicol Methods 2017 Jan - Feb;83:42-54. Epub 2016 Sep 17.
Japan Pharmaceutical Manufacturers Association Drug Evaluation Committee, Non-Clinical Evaluation Expert Committee, TF2, Japan; Consortium for Safety Assessment using Human iPS Cells (CSAHi): HEART team, Japan; Biopharmaceutical Assessments Core Function Unit Medicine Development Center Eisai Co., Ltd., Eisai Co., Ltd., Ibaraki, Japan.
Recent increasing evidence suggests that the currently-used platforms in vitro I and APD, and/or in vivo QT assays are not fully predictive for TdP, and do not address potential arrhythmia (VT and/or VF) induced by diverse mechanisms of action. In addition, other cardiac safety liabilities such as functional dysfunction of excitation-contraction coupling (contractility) and structural damage (morphological damage to cardiomyocytes) are also major causes of drug attrition, but current in vitro assays do not cover all these liabilities. We organized the Consortium for Safety Assessment using Human iPS cells (CSAHi; http://csahi. Read More
Gan To Kagaku Ryoho 2016 Apr;43(4):480-2
Chairperson, Drug Evaluation Committee, Japan Pharmaceutical Manufactures Association.
Pharmaceutical companies recognize the importance of post-marketing studies because they are crucial in the generation of clinical evidences for the usage of new medicines. To generate clinical evidences, quality of post-marketing studies should be well controlled from view point of "ethical conduction" and "reliability of results". In addition, control of conflict of interest (COI) between researchers and industries is also indispensable and is requested for the transparency of the studies. Read More
Regul Toxicol Pharmacol 2016 Jun 13;77:75-86. Epub 2016 Feb 13.
Preclinical Research Laboratories, Sumitomo Dainippon Pharma Co., Ltd., 3-1-98 Kasugade-naka, Konohana-ku, Osaka 554-0022, Japan; Consortium for Safety Assessment Using Human iPS Cells (CSAHi), Japan; Non-Clinical Evaluation Expert Committee, Drug Evaluation Committee, Japan Pharmaceutical Manufacturers Association (JPMA), 2-3-11 Nihonbashi-Honcho, Chuo-ku, Tokyo 103-0023, Japan. Electronic address:
In vitro screening of hERG channels are recommended under ICH S7B guidelines to predict drug-induced QT prolongation and Torsade de Pointes (TdP), whereas proarrhythmia is known to be evoked by blockage of other ion channels involved in cardiac contraction and compensation mechanisms. A consortium for drug safety assessment using human iPS cells-derived cardiomyocytes (hiPS-CMs), CSAHi, has been organized to establish a novel in vitro test system that would enable better prediction of drug-induced proarrhythmia and QT prolongation. Here we report the inter-facility and cells lot-to-lot variability evaluated with FPDc (corrected field potential duration), FPDc10 (10% FPDc change concentration), beat rate and incidence of arrhythmia-like waveform or arrest on hiPS-CMs in a multi-electrode array system. Read More
Bioorg Med Chem Lett 2016 Feb 8;26(4):1292-5. Epub 2016 Jan 8.
Sumitomo Dainippon Pharma Co., Ltd., 33-94 Enoki, Suita, Osaka 564-0053, Japan.
We have designed and efficiently synthesized novel 1-phenyl-6-aminouracils by replacing the chroman moiety in CX-659S, a nonsteroidal dermatologic candidate, with dimethyldihydrobenzofuranol to cancel CX-659S asymmetric center. Medicinal chemistry effort culminated in the discovery of 13d bearing a 3-methyl group at the 1-phenyl group as a promising compound. Compound 13d, having good in vitro ADME profile and moderate oral bioavailability in mice, showed potent anti-inflammatory activity against hapten-induced contact hypersensitivity reaction in mice following topical and oral administration. Read More
Seishin Shinkeigaku Zasshi 2015 ;117(9):796-801
In 2011, the Japanese Society of Psychiatry and Neurology released the Guidelines on Conflict of Interest(COI) in Clinical Research and detailed regulations. According to the Guidelines, the COI Committee has been engaged in COI management for a one-year trial period. The members of the Society have to disclose their COIs at the time of presentations, manuscript submissions, and publications; the board and committees members have to disclose their COIs to the President of the Society; and the President reports these COI disclosures to the COI Committee. Read More
J Pharmacol Toxicol Methods 2016 Mar-Apr;78:93-102. Epub 2015 Dec 4.
Non-Clinical Evaluation Expert Committee, Drug Evaluation Committee, Japan Pharmaceutical Manufacturers Association (JPMA), 2-3-11 Nihonbashi-Honcho, Chuo-ku, Tokyo 103-0023, Japan; Consortium for Safety Assessment using Human iPS Cells (CSAHi), Japan; Biopharmaceutical Assessments Core Function Unit, Eisai Product Creation Systems, Eisai Co., Ltd., 5-1-3 Tokodai, Tsukuba, Ibaraki 300-2635, Japan.
Introduction: Drug-induced QT prolongation is a major safety issue during drug development because it may lead to lethal ventricular arrhythmias. In this study, we evaluated the utility of multi-electrode arrays (MEA) with human induced pluripotent stem cell-derived cardiomyocytes (hiPS-CMs) to predict drug-induced QT prolongation and arrhythmia.
Methods: Ten facilities evaluated the effects of 7 reference drugs (E-4031, moxifloxacin, flecainide, terfenadine, chromanol 293B, verapamil, and aspirin) using a MED64 MEA system with commercially available hiPS-CMs. Read More
Proc Natl Acad Sci U S A 2015 Oct 28;112(41):12687-92. Epub 2015 Sep 28.
Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030;
Leiomodin (Lmod) is a class of potent tandem-G-actin-binding nucleators in muscle cells. Lmod mutations, deletion, or instability are linked to lethal nemaline myopathy. However, the lack of high-resolution structures of Lmod nucleators in action severely hampered our understanding of their essential cellular functions. Read More
J Pak Med Assoc 2015 Sep;65(9):978-83
Peshawar Medical College, Peshawar.
Objective: To conduct a bibliometric analysis of the Original articles published in the Journal of Pakistan Medical Association.
Methods: The study was conducted in Peshawar and comprised all Original articles published in the Journal of Pakistan Medical Association between 2009 and2013. The articles were downloaded from the Journal website and bibliometric parameters were analysed. Read More
Biologicals 2015 Sep 24;43(5):283-97. Epub 2015 Aug 24.
Pharma Biotechnology, France.
The regulation of human cell therapy products is a key factor in their development and use to treat human diseases. In that regard, there is a recognized need for a global effort to develop a set of common principles that may serve to facilitate a convergence of regulatory approaches to ensure the smooth and efficient evaluation of products. This conference, with experts from regulatory agencies, industry, and academia, contributed to the process of developing such a document. Read More
J Neuropathol Exp Neurol 2015 Jul;74(7):653-71
From the Instituto de Anatomía, Histología y Patología (MMG, RH, AO, NL, KV, CG, MCJ, FH, SR, MJ, EMR), Instituto de Neurociencias Clínicas (EO), Instituto de Obstetricia y Ginecología (FG), Universidad Austral de Chile, Valdivia, Chile; Facultad de Recursos Naturales (AO), Escuela de Medicina Veterinaria, Universidad Católica de Temuco, Araucania, Chile; Departments of Pediatric Neurology and Pediatrics (DAS), and Pathology and Medical Biology (WFAdD), University Medical Center, University of Groningen, Groningen, The Netherlands; Departamento de Biología Celular, Facultad de Ciencias, Universidad de Málaga, Málaga, Spain (AJJ, MDD-P, JMP-F); Department of Neurosurgery, Pediatric Neurosurgery Division, University of Utah, Salt Lake City, Utah (JPMA); and Department of Neurosurgery, Alpert Medical School at Brown University, Providence, Rhode Island (CEJ).
Fetal-onset hydrocephalus affects 1 to 3 per 1,000 live births. It is not only a disorder of cerebrospinal fluid dynamics but also a brain disorder that corrective surgery does not ameliorate. We hypothesized that cell junction abnormalities of neural stem cells (NSCs) lead to the inseparable phenomena of fetal-onset hydrocephalus and abnormal neurogenesis. Read More
Bioanalysis 2015 ;7(9):1151-6
11National Institute of Health Sciences, Kamiyoga 1-18-11, Setagaya-ku, Tokyo 158-8501, Japan.
J Pak Med Assoc 2015 May;65(5 Suppl 1):S79-80
Department of Endocrinology, Bharti Hospital and B.R.I.D.E., Karnal, India.
J Pak Med Assoc 2015 May;65(5 Suppl 1):S44-6
Editor-in-Chief, JPMA, Karachi.
Many people with diabetes, both type 1 and type 2, require insulin for maintainance of glycaemic control and health. Most of these people can observe the Ramadan fast, provided appropriate dosage adjustments are made, and basic rules of safety followed. This article describes modifications and precautions that are needed while prescribing insulin during Ramadan. Read More
J Pak Med Assoc 2015 May;65(5 Suppl 1):S1-2
Department of Endocrinology, Bharti Hospital and B.R.I.D.E., Karnal, India.
J Pharmacol Toxicol Methods 2015 Sep-Oct;75:17-26. Epub 2015 Apr 22.
Japanese Safety Pharmacology Society (JSPS), 3-39-22 Showa-machi, Maebashi, Gunma 371-8511, Japan; Japan iPS Cardiac Safety Assessment (JiCSA), 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan; Eisai Co., Ltd., 5-1-3 Tokodai, Tsukuba, Ibaraki 300-2635, Japan. Electronic address: http://www.j-sps.org/
Introduction: Multi-electrode array (MEA) systems and human induced pluripotent stem (iPS) cell-derived cardiomyocytes are frequently used to characterize the electrophysiological effects of drug candidates for the prediction of QT prolongation and proarrhythmic potential. However, the optimal experimental conditions for obtaining reliable experimental data, such as high-pass filter (HPF) frequency and cell plating density, remain to be determined.
Methods: Extracellular field potentials (FPs) were recorded from iPS cell-derived cardiomyocyte sheets by using the MED64 and MEA2100 multi-electrode array systems. Read More
J Pak Med Assoc 2014 Nov;64(11):1255-9
Objective: To determine the frequency pattern of CHO, protein and fat intake in 24 hours by Pakistani school children of different socioeconomic and cultural backgrounds) 6 to 16 years of age.
Methods: The cross-sectional study was a multistage stratified sampling, done in a part of nationwide survey funded by the Higher Education Commission, Pakistan (HEC, Ref no: 20-441/R&D/2008). Sample collection of the study was done from 2006-2009, and growth centile charts have already been published (JPMA 2012; 62:367-77). Read More
Yakugaku Zasshi 2015 ;135(2):291-5
Post Marketing Surveillance Expert Committee, Drug Evaluation Committee, Japan Pharmaceutical Manufacturers Association (JPMA).
Draft versions of two products of based on a "Drug Guide for Patients" have been prepared the guidelines proposed in "Research on risk communication between patients and healthcare professionals regarding information on safety measures for drugs, etc." by Health and Labour Sciences Research Grants. We conducted a questionnaire survey on the draft to identify issues regarding the contents and their preparation from the viewpoint of pharmaceutical companies as authors. Read More
J Pak Med Assoc 2013 Dec;63(12):1560-2
Journal of Pakistan Medical Association, Karachi.
J Pak Med Assoc 2013 Oct;63(10):1326
J Pak Med Assoc 2013 Nov;63(11):1446-7
Journal of Pakistan Medical Association, Karachi.
Kokuritsu Iyakuhin Shokuhin Eisei Kenkyusho Hokoku 2013 (131):25-34
Division of Pharmacology, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan.
In this study, we have standardized experimental protocols to evaluate the possibility of using cells differentiated from human induced pluripotent stem cells (hiPSCs) in the pre-clinical studies for the drug approval processes. Cells differentiated from hiPSC, especially cardiomyocytes, neurons and hepatocytes, are expected to be used as new pharmacological and toxicological assay tools. Current preclinical test methods have limitations for predicting clinical adverse drug reactions. Read More
Toxicol In Vitro 2013 Dec 14;27(8):2316-24. Epub 2013 Oct 14.
Department of Pharmacokinetics and Pharmacodynamics, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan. Electronic address:
The main purpose of the present study was to establish a non-animal photosafety assessment approach for cosmetics using in vitro photochemical and photobiochemical screening systems. Fifty-one cosmetics, pharmaceutics and other chemicals were selected as model chemicals on the basis of animal and/or clinical photosafety information. The model chemicals were assessed in terms of photochemical properties by UV/VIS spectral analysis, reactive oxygen species (ROS) assay and 3T3 neutral red uptake phototoxicity testing (3T3 NRU PT). Read More
J Pak Med Assoc 2013 Apr;63(4):445-7
Isra University, Hyderabad, Pakistan.
Objective: To compare two premier Pakistani medical journals for errors in references of original articles published in the year 2008.
Methods: All original articles of the Journal of Pakistan Medical Association and the Journal of the College of Physicians and Surgeons Pakistan published in 2008 were included in the study. References pertaining to journals were included in the study, whereas references pertaining to other sources such as books internet articles, websites and newspapers were excluded. Read More
J Pak Med Assoc 2012 Aug;62(8):859-61
J Pharmacol Toxicol Methods 2013 Jul-Aug;68(1):7-12. Epub 2013 Apr 6.
Health and Environmental Sciences Institute, 1156 15th Street, Northwest, Suite 200, Washington, DC 20005, USA.
Introduction: The evaluation of cardiovascular side-effects is a critical element in the development of all new drugs and chemicals. Cardiac safety issues are a major cause of attrition and withdrawal due to adverse drug reactions (ADRs) in pharmaceutical drug development.
Methods: The evolution of the HESI Technical Committee on Cardiac Safety from 2000-2013 is presented as an example of an effective international consortium of academic, government, and industry scientists working to improve cardiac safety. Read More
J Toxicol Sci 2012 ;37(4):667-73
Non-Clinical Evaluation Expert Committee, Drug Evaluation Committee, Japan Pharmaceutical Manufacturers Association, Tokyo, Japan.
The prompt and appropriate safety assessment of drug metabolite(s) was mentioned in regulatory guidances such as an International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH) guidance, entitled "Guidance on Non-clinical Safety Studies for the Conduct of Human Clinical Trials and Marketing Authorization for Pharmaceuticals" (ICH M3(R2)) implemented in January 1 of 2011 in Japan, and has become a significant issue in the drug development. Upon release of ICH M3(R2) Step 4, a survey was conducted between March and April 2010 on the safety assessment of drug metabolites in 63 member companies of the Japan Pharmaceutical Manufacturers Association (JPMA). The Pharmacokinetics Team in the Non-Clinical Evaluation Expert Committee in JPMA conducted a questionnaire survey and compiled the results to comprehend how safety of drug metabolites are currently assessed at research-based pharmaceutical companies in Japan. Read More
J Pak Med Assoc 2012 Mar;62(3):262-8
Department of Radiation Oncology, Aga Khan University Hospital, Karachi.
Merkel cell carcinoma (MCC), is a rare, highly malignant skin tumour, with a poor prognosis. Though the aetiology of MCC is not known, but there are several features that it shares with melanoma. These include the natural history, clinical features and behaviour, e. Read More
Regul Toxicol Pharmacol 2012 Aug 9;63(3):480-8. Epub 2012 Jun 9.
European Commission Joint Research Centre, Ispra, Italy.
This is the report from the "ECVAM-EFPIA workshop on 3T3 NRU Phototoxicity Test: Practical Experience and Implications for Phototoxicity Testing", jointly organized by ECVAM and EFPIA and held on the 25-27 October 2010 in Somma Lombardo, Italy. The European Centre for the Validation of Alternative Methods (ECVAM) was established in 1991 within the European Commission Joint Research, based on a Communication from the European Commission (1991). The main objective of ECVAM is to promote the scientific and regulatory acceptance of alternative methods which are of importance to the biosciences and which reduce, refine and replace the use of laboratory animals. Read More
Drug Discov Ther 2012 Apr;6(2):102-7
Graduate School of Pharmaceutical Science, The University of Tokyo, Tokyo, Japan.
The trend of biomarker use in drug interventional clinical studies was analyzed using ClinicalTrials.gov to provide an overview of how biomarkers are used to streamline clinical studies and to examine regional differences. A total of 3,383 clinical study data was analyzed according to phase, region, sponsor, and therapeutic class. Read More
J Pak Med Assoc 2010 Sep;60(9):745-50
Pakistan Medical Research Council, Karachi.
Objectives: To compare the statistical methods, types of article and design of studies used in 1998 and 2007 articles of leading indexed and non-indexed medical journals of Pakistan.
Methods: Six leading medical journals of Pakistan: (1) JCPSP, (2) JPMA, (3) JAMC, (4) PJMS, (5) PJMR and (6) PAFMJ, were selected for this study. Articles reviewed were 1057 to achieve the above mentioned objective. Read More