4,734 results match your criteria JPEN: Journal of Parenteral and Enteral Nutrition [Journal]


Incidence and Effects of Feeding Intolerance in Trauma Patients.

JPEN J Parenter Enteral Nutr 2018 Dec 3. Epub 2018 Dec 3.

Department of Medical Chemistry, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.

Background: Although feeding intolerance is a common complication in trauma patients, the incidence, development, and effects are poorly understood.

Methods: We performed a retrospective study in which trauma patients were classified as having feeding intolerance based on time to reach feeding goal. Subsequently, we sorted patients by gastric residual volumes (GRVs) or symptoms of slowed gastrointestinal motility. Read More

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December 2018
2 Reads

Prediction of Prolonged ICU Stay in Cardiac Surgery Patients as a Useful Method to Identify Nutrition Risk in Cardiac Surgery Patients: A Post Hoc Analysis of a Prospective Observational Study.

JPEN J Parenter Enteral Nutr 2018 Dec 2. Epub 2018 Dec 2.

Clinical Evaluation Research Unit, Kingston General Hospital, Kingston, Ontario, Canada.

Background: Cardiovascular surgery patients with a prolonged intensive care unit (ICU) stay may benefit most from early nutrition support. Using established scoring systems for nutrition assessment and operative risk stratification, we aimed to develop a model to predict a prolonged ICU stay ≥5 days in order to identify patients who will benefit from early nutrition interventions.

Methods: This is a retrospective analysis of a prospective observational study of patients undergoing elective valvular, coronary artery bypass grafting, or combined cardiac surgery. Read More

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December 2018

Editorial Effort for the EFFORT Trial Manuscript Was Worth the Effort.

Authors:
David A August

JPEN J Parenter Enteral Nutr 2018 Nov 29. Epub 2018 Nov 29.

Rutgers Cancer Institute of New Jersey, Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.

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November 2018

Time to Full Enteral Feeding for Very Low-Birth-Weight Infants Varies Markedly Among Hospitals Worldwide But May Not Be Associated With Incidence of Necrotizing Enterocolitis: The NEOMUNE-NeoNutriNet Cohort Study.

JPEN J Parenter Enteral Nutr 2018 Nov 22. Epub 2018 Nov 22.

Department of Neonatology, Shenzhen Bao'an Maternal and Child Health Hospital, Shenzhen, China.

Background: Transition to enteral feeding is difficult for very low-birth-weight (VLBW; ≤1500 g) infants, and optimal nutrition is important for clinical outcomes.

Method: Data on feeding practices and short-term clinical outcomes (growth, necrotizing enterocolitis [NEC], mortality) in VLBW infants were collected from 13 neonatal intensive care units (NICUs) in 5 continents (n = 2947). Specifically, 5 NICUs in Guangdong province in China (GD), mainly using formula feeding and slow feeding advancement (n = 1366), were compared with the remaining NICUs (non-GD, n = 1581, Oceania, Europe, United States, Taiwan, Africa) using mainly human milk with faster advancement rates. Read More

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November 2018
4 Reads
3.151 Impact Factor

Factors Related to the Assessment of Resting Metabolic Rate in Critically Ill Patients.

JPEN J Parenter Enteral Nutr 2018 Nov 21. Epub 2018 Nov 21.

Department of Clinical Nutrition, Penn State Health, Milton S. Hershey Medical Center, Hershey, Pennsylvania, USA.

Background: Predicting resting metabolic rate (RMR) in mechanically ventilated, critically ill patients is an important part of the nutrition care in such patients.

Methods: RMR and associated clinical data from various studies of mechanically ventilated, critically ill patients were combined, and the impact of body size, age, reason for admission, and sedation level were analyzed along with prediction methods of RMR (the American Society for Parenteral and Enteral Nutrition [ASPEN] standards and the Penn State equation).

Results: Among 826 measurements, trauma patients had a higher RMR than surgical and medical patients (2077 ± 290 vs 1987 ± 282 kcal/d; P < . Read More

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November 2018
2 Reads

Prevalence, Characteristics, and Outcome of Cow's Milk Protein Allergy in Chinese Infants: A Population-Based Survey.

JPEN J Parenter Enteral Nutr 2018 Nov 19. Epub 2018 Nov 19.

Department of Gastroenterology, Guangzhou Women and Children's Medical Center of Guangzhou Medical University, Guangzhou, China.

Background: Cow's milk protein allergy (CMPA) is commonly seen in children. There have been no reports of the true prevalence of CMPA in Chinese infants. The aim of this population-based study is to determine the prevalence, clinical characteristics, and outcome of CMPA in Chinese infants. Read More

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November 2018
7 Reads
3.151 Impact Factor

Effects of Nutrition Supplementation on Osmolality of Expressed Human Milk.

JPEN J Parenter Enteral Nutr 2018 Nov 19. Epub 2018 Nov 19.

Cohen Children's Medical Center, Northwell Health, New Hyde Park, New York, USA.

Background: Provision of human milk to premature infants optimizes outcomes, but it must be supplemented to meet their nutrient and caloric requirements for growth. Our objective was to quantify the osmolality of human milk mixed with commercially available human milk fortifiers (HMF) and powdered infant formula, as currently fed to premature infants, simulating standard neonatal intensive care unit feeding practices for mixing and refrigerator storage.

Methods: Expressed human milk (EHM) samples obtained from mothers of premature infants (≤32 weeks gestation) were mixed with standard commercial products, and osmolalities were quantified. Read More

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November 2018
6 Reads

Vitamin C Supplementation in the Critically Ill: A Systematic Review and Meta-Analysis.

JPEN J Parenter Enteral Nutr 2018 Nov 19. Epub 2018 Nov 19.

Clinical Evaluation Research Unit, Kingston General Hospital, Kingston, Ontario, Canada and Department of Critical Care, Queen's University, Kingston, Ontario, Canada.

Vitamin C, an enzyme cofactor and antioxidant, could hasten the resolution of inflammation, oxidative stress, and microvascular dysfunction. While observational studies have demonstrated that critical illness is associated with low levels of vitamin C, randomized controlled trials (RCTs) of vitamin C, alone or in combination with other antioxidants, have yielded contradicting results. We searched MEDLINE, EMBASE, CINAHL, and the Cochrane Central Register of Controlled Trials (inception to December 2017) for RCTs comparing vitamin C, by enteral or parenteral routes, with placebo or none, in intensive care unit (ICU) patients. Read More

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November 2018
10 Reads

Standardized Nutrition Protocol for Very Low-Birth-Weight Infants Resulted in Less Use of Parenteral Nutrition and Associated Complications, Better Growth, and Lower Rates of Necrotizing Enterocolitis.

JPEN J Parenter Enteral Nutr 2018 Nov 9. Epub 2018 Nov 9.

Division of Neonatology, Hassenfeld Children's Hospital at NYU Langone, New York University School of Medicine, New York, New York, USA.

Background: We assessed the impact of a standardized nutrition initiative for very low-birth-weight (VLBW) infants on their nutrition and clinical outcomes.

Methods: This was a prospective analysis of VLBW infants born before and after the initiation of a nutrition protocol. This protocol included trophic feeds, feeding advancement, fortification guidelines, parameters on the concentration of parenteral nutrition (PN), and the discontinuation of PN and central lines. Read More

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November 2018
4 Reads

Addition of Insulin to Parenteral Nutrition Is Not Universally Safe.

JPEN J Parenter Enteral Nutr 2018 Nov 8. Epub 2018 Nov 8.

Division of Human Nutrition, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, Western Cape, South Africa.

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November 2018

Long-Term Outcomes in Children With Intestinal Failure-Associated Liver Disease Treated With 6 Months of Intravenous Fish Oil Followed by Resumption of Intravenous Soybean Oil.

JPEN J Parenter Enteral Nutr 2018 Nov 8. Epub 2018 Nov 8.

Department of Pediatrics, Division of Neonatology, David Geffen School of Medicine, University of California, Los Angeles, California.

Background: Intravenous soybean oil (SO) is a commonly used lipid emulsion for children with intestinal failure (IF); however, it is associated with IF-associated liver disease (IFALD). Studies have demonstrated that intravenous fish oil (FO) is an effective treatment for IFALD. However, there is a lack of long-term data on children who stop FO and resume SO. Read More

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November 2018

JPEN Journal Club 40. Differences in Nominal Significance.

Authors:
Ronald L Koretz

JPEN J Parenter Enteral Nutr 2018 Nov 8. Epub 2018 Nov 8.

Olive View-UCLA Medical Center, David Geffen-UCLA School of Medicine, Sylmar and Los Angeles, California, USA.

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November 2018

Author Response to "Addition of Insulin to Parenteral Nutrition Is Not Universally Safe".

JPEN J Parenter Enteral Nutr 2018 Nov 8. Epub 2018 Nov 8.

Cambridge Intestinal Failure and Transplant, Addenbrooke's Hospital, Cambridge, UK.

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November 2018
1 Read

Characterizing Exclusively Breastfed Infant Stool via a Novel Infant Stool Scale.

JPEN J Parenter Enteral Nutr 2018 Nov 29;42 Suppl 1:S5-S11. Epub 2018 Oct 29.

Procter & Gamble Company, Cincinnati, Ohio, USA.

Analysis of stool has long been a diagnostic tool across a number of disease states. Currently, there are two stool scales in clinical use, the Bristol Stool Scale and the Amsterdam Infant Stool Scale. However, the existing categorizations for stool may not sufficiently cover the broad range of stool output for exclusively breastfed infants. Read More

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November 2018

Citrulline Generation Test: What Does It Measure?

JPEN J Parenter Enteral Nutr 2018 Oct 24. Epub 2018 Oct 24.

USDA/ARS Children's Nutrition Research Center, Baylor College of Medicine, Houston, Texas, USA.

Background: The citrulline generation test (CGT) has been proposed as a tool to determine gut function. However, the increase in plasma citrulline concentration that follows a bolus dose of alanyl-glutamine may also result from a reduction in citrulline clearance due to competition with glutamine for transport.

Materials And Methods: A swine model was developed, and stable isotope tracers were used to determine the mechanism behind the increase in plasma citrulline that follows a bolus dose of alanyl-glutamine. Read More

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October 2018
6 Reads

Dietary Management of Propionic Acidemia: Parent Caregiver Perspectives and Practices.

JPEN J Parenter Enteral Nutr 2018 Oct 24. Epub 2018 Oct 24.

Social and Behavioral Research Branch, Social Network Methods Section, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA.

Background: Propionic acidemia (PA), an autosomal recessive metabolic disorder, has an estimated incidence of 1:105,000-130,000 in the United States. Nutrition management is a main intervention for PA. Research in inborn errors of metabolism such as phenylketonuria has identified association of parental perceptions and practices with dietary outcomes. Read More

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October 2018
3 Reads

Overnight Steady-State Infusions of Parenteral Nutrition on Myosin Heavy Chain Transcripts in Rectus Abdominis Muscle Related to Amino Acid Transporters, Insulin-like Growth Factor 1, and Blood Amino Acids in Patients Aimed at Major Surgery.

JPEN J Parenter Enteral Nutr 2018 Oct 22. Epub 2018 Oct 22.

Surgical Metabolic Research Lab, Department of Surgery, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Sweden.

Background: Evaluation of improvements by nutrition support to severely ill patients requires sensitive methods to demonstrate activation of protein synthesis in various tissues from groups with a limited number of patients to be statistically efficient. This study examines effects of standard parenteral nutrition (PN) on abdominal muscle transcripts of amino acid (AA) transporters, myosin heavy chains (MHCs), and the insulin-like growth factor 1 and its receptor (IGF-1/IGF-1R) in patients aimed at major surgery.

Methods: Twenty-two randomized patients received steady-state PN (0. Read More

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October 2018

Vitamin C Status in Hospitalized Adults According to Subjective Global Assessment Method.

JPEN J Parenter Enteral Nutr 2018 Oct 22. Epub 2018 Oct 22.

Department of Internal Medicine, Federal University of Triângulo Mineiro, Uberaba/MG, Brazil.

Background: The subjective global assessment (SGA) is a powerful tool for nutrition status assessment. Our aim was to compare vitamin C serum levels among patients classified as A, B, or C in the SGA.

Methods: One hundred-and-fifty adults in the wards of the University Hospital participated in this study. Read More

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October 2018
3 Reads

American Society for Parenteral and Enteral Nutrition Guidelines for the Selection and Care of Central Venous Access Devices for Adult Home Parenteral Nutrition Administration.

JPEN J Parenter Enteral Nutr 2018 Oct 19. Epub 2018 Oct 19.

Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago Illinois.

This document represents the American Society for Parenteral and Enteral Nutrition (ASPEN) clinical guidelines to describe best practices in the selection and care of central venous access devices (CVADs) for the infusion of home parenteral nutrition (HPN) admixtures in adult patients. The guidelines targeted adults >18 years of age in which the intervention or exposure had to include HPN that was administered via a CVAD. Case studies, non-English studies, or studies of CVAD no longer available in the United States were excluded. Read More

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October 2018

Close Relationship Between Immunological/Inflammatory Markers and Myopenia and Myosteatosis in Patients With Colorectal Cancer: A Propensity Score Matching Analysis.

JPEN J Parenter Enteral Nutr 2018 Oct 18. Epub 2018 Oct 18.

Department of Gastrointestinal and Pediatric Surgery, Division of Reparative Medicine, Institute of Life Sciences, Mie University Graduate School of Medicine, Mie, Japan.

Background: The systemic inflammatory response (SIR) via host-tumor interactions has been termed the seventh hallmark of cancer, and several studies demonstrated that SIR might be a pivotal mediator for progression of cancer cachexia. The objective of this study was to clarify the correlation between sarcopenia and SIR in patients with colorectal cancer (CRC).

Methods: A total of 308 patients with CRC were enrolled in this study. Read More

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October 2018

Preoperative Oral Branched-Chain Amino Acid Supplementation Suppresses Intraoperative and Postoperative Blood Lactate Levels in Patients Undergoing Major Hepatectomy.

JPEN J Parenter Enteral Nutr 2018 Oct 18. Epub 2018 Oct 18.

Division of Hepato-biliary-pancreatic Surgery, Department of Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.

Background: Lactate production is exacerbated by surgical stress. We sought to determine whether branched-chain amino acid (BCAA) supplementation could decrease blood lactate levels in patients undergoing hepatectomy.

Methods: A total of 275 consecutive patients who underwent hepatectomy of ≥2 segments were retrospectively reviewed. Read More

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October 2018

AGREEing on Guidelines for Nutrition Management of Adult Severe Burn Patients.

JPEN J Parenter Enteral Nutr 2018 Oct 15. Epub 2018 Oct 15.

Department of Rheumatology and Clinical Immunology, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece.

Background: Severe burns are associated with a plethora of profound metabolic, immunologic, and physiologic responses, demanding prompt and adequate management. The objective of the present study was to review, compare, and critically appraise medical nutrition therapy guidelines for adult patients with severe burns, and produce salient points for the future update of relevant guidelines.

Methods: A total of 8 clinical practice guidelines developed by the American Burn Association (ABA), the European Burn Association (EBA), the European Society for Parenteral and Enteral Nutrition (ESPEN), the Midlands National Health Service, the Society for Critical Care Medicine (SCCM)/American Society for Parenteral and Enteral Nutrition (ASPEN), the Spanish Society of Intensive Care Medicine and Coronary Units and Spanish Society of Parenteral and Enteral Nutrition, the Indian Association for Parenteral and Enteral Nutrition (IAPEN), and the International Society for Burn Injury regarding medical nutrition therapy in burn patients was independently reviewed by a team of 4 multidisciplinary researchers using the Appraisal of Guidelines for Research & Evaluation (AGREE II) instrument. Read More

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October 2018
2 Reads

Poor Social Support and Unemployment Are Associated With Negative Affect in Home Parenteral Nutrition-Dependent Patients With Chronic Intestinal Failure.

JPEN J Parenter Enteral Nutr 2018 Oct 9. Epub 2018 Oct 9.

Intestinal Failure Unit, Salford Royal NHS Foundation Trust, Salford, United Kingdom.

Background: Home parenteral nutrition (HPN) provides life-sustaining treatment for people with chronic intestinal failure (CIF). Poor quality of life is reported in association with the burden of HPN and the underlying condition leading to intestinal failure (IF). However, levels of negative affect (NA), incorporating anxiety and depression, have not been reported in CIF. Read More

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October 2018
1 Read

JPEN Journal Club 39. Validating a Surrogate.

Authors:
Ronald L Koretz

JPEN J Parenter Enteral Nutr 2018 Oct 9. Epub 2018 Oct 9.

Olive View-UCLA Medical Center and the David Geffen-UCLA School of Medicine, Sylmar and Los Angeles, California, USA.

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October 2018

Hypoalbuminemia: Pathogenesis and Clinical Significance.

JPEN J Parenter Enteral Nutr 2018 Oct 4. Epub 2018 Oct 4.

Department of Clinical Chemistry, University of Liverpool, Liverpool, UK.

Hypoalbuminemia is associated with inflammation. Despite being addressed repeatedly in the literature, there is still confusion regarding its pathogenesis and clinical significance. Inflammation increases capillary permeability and escape of serum albumin, leading to expansion of interstitial space and increasing the distribution volume of albumin. Read More

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October 2018
9 Reads

Dietary Nondigestible Polysaccharides Ameliorate Colitis by Improving Gut Microbiota and CD4 Differentiation, as Well as Facilitating M2 Macrophage Polarization.

JPEN J Parenter Enteral Nutr 2018 Sep 13. Epub 2018 Sep 13.

Department of Colorectal Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, Jiangsu, China.

Background: The aim of this study was to investigate the therapeutic mechanism of a specific multifiber mix diet (MF) designed to match the fiber content of a healthy diet in interleukin-10 knockout (IL-10) mice with spontaneous chronic colitis displaying similar characteristics to those of human Crohn's disease (CD).

Methods: Sixteen-week-old IL-10 mice were used for the experiments with MF diet for 4 weeks. Severity of colitis, the composition of the fecal microbiota, expression of Th1/Th17 cells, myeloperoxidase (MPO) concentrations, and inflammatory cytokines and chemokines (tumor necrosis factor-α [TNF-α], IL-6, macrophage inflammatory protein [MIP]-2, monocyte chemoattractant protein-1 [MCP-1], and MIP-1α), as well as arginase 1 (Arg1) and signal transducers and activators of transcription 6 (STAT6) proteins, were measured at the end of the experiment. Read More

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September 2018
2 Reads

Influences of Short-Term Fasting and Carbohydrate Supplementation on Gut Immunity and Mucosal Morphology in Mice.

JPEN J Parenter Enteral Nutr 2018 Sep 27. Epub 2018 Sep 27.

Department of Gastrointestinal Surgery, Graduate School of Medicine, the University of Tokyo, Tokyo, Japan.

Background: Preoperative carbohydrate (CHO) supplementation has been recommended in enhanced recovery after surgery protocols. However, the effects of CHO supplementation on gut and systemic immunity are not well understood.

Methods: Mice (n = 60) were randomized to 1 of the following 5 groups: control (ad lib feeding), 12-hour fasting without CHO administration (fasting), and 12 hours of fasting with CHO administration at 2, 4, and 8 hours before sacrifice. Read More

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September 2018

Dietary Management of Blood Glucose in Medical Critically Ill Overweight and Obese Patients: An Open-Label Randomized Trial.

JPEN J Parenter Enteral Nutr 2018 Sep 27. Epub 2018 Sep 27.

Nestlé Health Science, Bridgewater, New Jersey, USA.

Background: Enteral nutrition (EN) increases hyperglycemia due to high carbohydrate concentrations while providing insufficient protein. The study tested whether an EN formula with very high-protein- and low-carbohydrate-facilitated glucose control delivered higher protein concentrations within a hypocaloric protocol.

Methods: This was a multicenter, randomized, open-label clinical trial with parallel design in overweight/obese mechanically ventilated critically ill patients prescribed 1. Read More

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September 2018

Effect of Different Tube Feeding Methods on the Delivery of Docosahexaenoic and Arachidonic Acid: An In Vitro Pilot Study.

JPEN J Parenter Enteral Nutr 2018 Sep 27. Epub 2018 Sep 27.

Neonatal Intensive Care Unit, St. Orsola-Malpighi University Hospital, Bologna, Italy.

Background: Arachidonic acid (AA) and docosahexaenoic acid (DHA) are crucial for neural and visual development after premature birth. Preterm infants usually require tube feeding (TF) until the achievement of adequate oral feeding skills; the impact of TF on DHA and AA delivery has not been investigated yet. This study aimed to evaluate the effect of different TF techniques on the delivery of AA and DHA contained in human milk (HM). Read More

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September 2018
3 Reads

The Effect of Higher Protein Dosing in Critically Ill Patients: A Multicenter Registry-Based Randomized Trial: The EFFORT Trial.

JPEN J Parenter Enteral Nutr 2018 Sep 27. Epub 2018 Sep 27.

University of Pennsylvania School of Nursing, Philadelphia, Pennsylvania, USA.

Current randomized trials and observational studies evaluating higher versus lower protein doses in critically ill patients yield inconclusive results. Because of few studies and methodologic limitations, clinical guidelines suggest a wide range of protein intake based on weak evidence. Clinical equipoise about protein dosing exists. Read More

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September 2018
12 Reads

Primer on Study Design, Type I and Type II Errors, Power, and Statistical Significance to Ensure Interpretation of Clinical Trial Results Remains Clearly INTACT.

JPEN J Parenter Enteral Nutr 2018 Sep 25. Epub 2018 Sep 25.

Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, IL.

We thank Drs. Patel, Martindale, and Heyland for their interest in our most recent study exploring the role of early exposure to recommended energy delivery in critically ill patients with acute respiratory distress syndrome. Their stated concerns center around 3 major areas: (1) the comparability of the population in our study with those of INTACT (Intensive Nutrition in Acute Lung Injury: A Clinical Trial); (2) their confusion on the analysis of the relationship between the likelihood of death with energy exposure (table 1 in our article ); and (3) their apparent misunderstanding of type I error, type II error, P-values, and power analysis. Read More

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September 2018

Messy Play Therapy in the Treatment of Food Aversion in a Patient With Intestinal Failure: Our Experience.

JPEN J Parenter Enteral Nutr 2018 Sep 25. Epub 2018 Sep 25.

Department of Pediatric Surgery, Meyer Children's Hospital, University of Florence, Florence, Italy.

Background: Food aversion (FA) is an eating behavior where children refuse solid or fluid intake. FA can compromise the weaning off parenteral nutrition (PN) in children with intestinal failure (IF), reducing their quality of life (QoL). Around 25% of children with IF experience FA, but few data are available on interventions to get over FA. Read More

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September 2018
1 Read

Unraveling Methodology to Ensure the Search for Optimal Nutrition Quantity in Acute Respiratory Distress Syndrome Remains INTACT.

JPEN J Parenter Enteral Nutr 2018 Sep 25. Epub 2018 Sep 25.

Clinical Evaluation Research Unit, Department of Public Health Sciences, Queen's University, Department of Critical Care Medicine, Kingston General Hospital, Kingston, Ontario, Canada.

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September 2018
3 Reads

Optimization of Nutrition Therapy with the Use of Calorimetry to Determine and Control Energy Needs in Mechanically Ventilated Critically Ill Patients: The ONCA Study, a Randomized, Prospective Pilot Study.

JPEN J Parenter Enteral Nutr 2018 Sep 25. Epub 2018 Sep 25.

Department of Nutritional Medicine, University of Hohenheim, Stuttgart, Germany.

Background: Adequate nutrition therapy in critically ill patients poses a challenge because of the variable energy and substrate needs. The objective was to investigate whether nutrition therapy involving indirect calorimetry (IC), instead of equations for assessment of energy needs, could improve the nutrition status of critically ill patients.

Methods: Forty mechanically ventilated patients were randomized into a group in which energy needs were controlled by calorimetry (IC group) and a group treated with a formula-based approach reflecting standard care (SC group). Read More

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September 2018
5 Reads

Volume-Based vs Rate-Based Enteral Nutrition in the Intensive Care Unit: Impact on Nutrition Delivery and Glycemic Control.

JPEN J Parenter Enteral Nutr 2018 Sep 19. Epub 2018 Sep 19.

School of Health Professions, Nutritional Sciences, Rutgers University, New Brunswick, New Jersey, USA.

Background: Underfeeding with enteral nutrition (EN) is prevalent in intensive care units (ICUs) and associated with negative outcomes. This study evaluated the impact of volume-based EN (VBEN) vs rate-based EN (RBEN) on delivery of prescribed energy and protein, and glycemic control (GC).

Methods: This retrospective study included adult patients who require mechanical ventilation within 48 hours of ICU admission and with an RBEN (n = 85) or VBEN (n = 86) order for ≥3 consecutive days during the first 12 ICU days. Read More

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September 2018
5 Reads

Economic Evaluation of Nutrition Support in the Prevention and Treatment of Pressure Ulcers in Acute and Chronic Care Settings: A Systematic Review.

JPEN J Parenter Enteral Nutr 2018 Sep 12. Epub 2018 Sep 12.

School of Human Movement and Nutrition Sciences, University of Queensland, St. Lucia, QLD 4072, Queensland, Australia.

Background: Recent developments in nutrition intervention indicated clinical effectiveness for pressure ulcer (PU) prevention and treatment, but it is important to assess whether they are cost-effective. The aims of this systematic review are to determine the cost-effectiveness and clinical outcomes of nutrition support in PU prevention and treatment.

Methods: A systematic search of randomized controlled trials, observational studies, and statistical models that investigated cost-effectiveness and economic outcomes for prevention and/or treatment of PUs were performed using standard literature and electronic databases. Read More

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September 2018

JPEN Journal Club 38. One-Tailed Testing.

Authors:
Ronald L Koretz

JPEN J Parenter Enteral Nutr 2018 Nov 10;42(8):1358-1360. Epub 2018 Sep 10.

Olive View-University of California Los Angeles Medical Center, David Geffen- University of California Los Angeles School of Medicine, Sylmar and Los Angeles, California, USA.

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November 2018

"I Wouldn't Ever Want It": A Qualitative Evaluation of Patient and Caregiver Perceptions Toward Enteral Tube Feeding in Hip Fracture Inpatients.

JPEN J Parenter Enteral Nutr 2018 Sep 10. Epub 2018 Sep 10.

School of Human Movement and Nutrition Sciences, University of Queensland, Brisbane, Queensland, Australia.

Background: One in 2 hip fracture inpatients are malnourished on admission to hospital, with many experiencing nutrition decline during their length of stay. Despite this, enteral tube feeding (ETF) is rarely used in this population. As patient/caregiver viewpoints regarding the utility of ETF remain unclear, this study explored the perceptions of hip fracture inpatients and caregivers toward ETF use to assist recovery. Read More

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September 2018
5 Reads

GLIM Criteria for the Diagnosis of Malnutrition: A Consensus Report From the Global Clinical Nutrition Community.

JPEN J Parenter Enteral Nutr 2018 Sep 2. Epub 2018 Sep 2.

Department of Gastroenterology, Clinic of Intestinal Diseases and Nutritional Support, Hopital Erasme, Free University of Brussels, Brussels, Belgium.

Background: This initiative aims to build a global consensus around core diagnostic criteria for malnutrition in adults in clinical settings.

Methods: The Global Leadership Initiative on Malnutrition (GLIM) was convened by several of the major global clinical nutrition societies. Empirical consensus was reached through a series of face-to-face meetings, telephone conferences, and e-mail communications. Read More

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September 2018
66 Reads

Calcium Chloride and Calcium Gluconate in Neonatal Parenteral Nutrition Solutions with Added Cysteine: Compatibility Studies Using Laser Light Obscuration Methodology.

JPEN J Parenter Enteral Nutr 2018 Aug 29. Epub 2018 Aug 29.

Randall Children's Hospital at Legacy Emanuel, Portland, Oregon, USA.

Background: Parenteral nutrition (PN) solutions containing calcium gluconate (CaGlu) and cysteine have elevated particle counts when analyzed using laser light obscuration (LO) as recommended by the United States Pharmacopeia (USP). There are no compatibility studies for solutions compounded with cysteine and containing calcium chloride (CaCl ) using LO. The purpose of this study was to conduct compatibility testing for neonatal PN solutions containing CaCl and CaGlu with cysteine. Read More

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Cost, Time, and Error Assessment During Preparation of Parenteral Nutrition: Multichamber Bags Versus Hospital-Compounded Bags.

JPEN J Parenter Enteral Nutr 2018 Aug 29. Epub 2018 Aug 29.

Pharmacoeconomics & Outcomes-Research-Iberia, Pozuelo de Alarcón, Spain.

Background: Parenteral nutrition (PN) is associated with material and manpower costs and requires preparation time. The aim of this study was to evaluate the cost of PN using multichamber bags (MCBs) compared with hospital-compounded bags (COBs). The secondary aim of this study was to assess and compare preparation time and errors related to the production and preparation processes of PN bags. Read More

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August 2018
9 Reads

Early Postoperative Oral Feeding After Total Gastrectomy in Gastric Carcinoma Patients: A Retrospective Before-After Study Using Propensity Score Matching.

Authors:
Aelee Jang Oh Jeong

JPEN J Parenter Enteral Nutr 2018 Aug 25. Epub 2018 Aug 25.

Department of Surgery, Chonnam National University School of Medicine, Jeollanam-do, South Korea.

Background: Despite its clinical benefits, early oral nutrition after total gastrectomy is not widely implemented because of concerns about tolerability and safety. We investigated the feasibility and safety of early oral nutrition after total gastrectomy in gastric carcinoma patients.

Methods: This is a retrospective before-after study. Read More

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Milk Fat Globule Membrane Inhibits NLRP3 Inflammasome Activation and Enhances Intestinal Barrier Function in a Rat Model of Short Bowel.

JPEN J Parenter Enteral Nutr 2018 Aug 24. Epub 2018 Aug 24.

Department of Clinical Nutrition, Xin Hua Hospital affiliated with Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Background: The milk fat globule membrane (MFGM) contains various bioactive components which have been shown to maintain gut barrier integrity. This study aimed to evaluate the protective effects of MFGM on intestinal barrier function and its possible mechanisms in a rat model of short bowel syndrome (SBS).

Materials And Methods: Five-week-old male Sprague-Dawley rats were divided into 3 groups (n = 8 per group), consisting of Sham group and rats submitted to massive small-bowel resection then supplemented with either water (SBS) or 1. Read More

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August 2018
10 Reads

Burden of Underweight in Israel.

JPEN J Parenter Enteral Nutr 2018 Aug 25. Epub 2018 Aug 25.

Department of Nutrition, Ministry of Health, Jerusalem, Israel.

Background: This study measures the burden of chronic diseases associated with being underweight.

Methods: Underweight prevalence in the community was obtained from national survey data, together with hospital use rates for malnourished and non-malnourished persons for diagnoses associated with underweight. Meta-analyses of published literature calculated the following disease-specific relative risks: incidence of underweight-associated disease (UAD), mortality from UAD, and all-cause and disease-specific mortality after hospitalization in underweight persons. Read More

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August 2018
21 Reads

Impact of Clinical Use of Parenteral Lipid Emulsions on Bile Acid Metabolism and Composition in Neonatal Piglets.

JPEN J Parenter Enteral Nutr 2018 Aug 23. Epub 2018 Aug 23.

Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.

Background: Neonates with intestinal failure dependent on parenteral nutrition (PN) are at risk of intestinal failure-associated liver disease (IFALD). PN lipid composition relates to the risk of IFALD, but the mechanisms are poorly understood. We investigated the effects of soybean oil (SO), a mixed-lipid (ML) emulsion containing fish oil (FO), and a pure FO. Read More

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August 2018
6 Reads

Effect of Delaying Replacement of Parenteral Nutrition Intravenous Administration Sets: Preclinical Experiments and a Dynamic Laboratory Model of Microbial Colonization.

JPEN J Parenter Enteral Nutr 2018 Aug 8;42(6):987-997. Epub 2018 Jan 8.

National Centre of Research Excellence in Nursing, Menzies Health Institute Queensland, Griffith University, Queensland, Australia.

Background: Recommendations prescribe daily intravenous administration set (IVAS) replacement for parenteral nutrition (PN) comprising intravenous fat emulsions (IVFE) due to risk of micro-organism growth and resultant central-line associated bloodstream infections (CLABSIs), but system disconnection for this practice may allow contamination and CLABSIs.

Materials And Methods: Laboratory experiments and model development were used to simulate PN administration after contamination from healthcare workers' hands. This study observed the growth of micro-organisms known to cause CLABSIs in a variety of PN and other IV fluids and developed a model to investigate the effect of delaying IVAS replacement on microbial growth for up to 7 days. Read More

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August 2018
3 Reads
3.150 Impact Factor

Soluble Mediators From Lactobacillus rhamnosus Gorbach-Goldin Support Intestinal Barrier Function in Rats After Massive Small-Bowel Resection.

JPEN J Parenter Enteral Nutr 2018 Aug 9;42(6):1026-1034. Epub 2018 Jan 9.

Department of Clinical Nutrition, Xin Hua Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Background: Intestinal barrier plays an essential role in maintaining gastrointestinal health. This study aimed to explore the effects of a soluble mediator preparation derived from Lactobacillus rhamnosus Gorbach-Goldin (LGG) on intestinal barrier function in a rat model of short bowel syndrome (SBS).

Methods: Six-week-old male Sprague-Dawley rats underwent 80% small-bowel resection (SBR) and then were supplemented with water (SBS), 5 × 10 colony-forming unit viable LGG (SBS+LGG), or the LGG soluble mediators (SBS+LSM) in an equivalent dose to LGG by intragastric gavage daily from day 2 throughout day 14 after operation. Read More

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August 2018
10 Reads

A New Model for Non-Lipid Compounded Neonatal Parenteral Nutrition Solution Osmolality.

JPEN J Parenter Enteral Nutr 2018 Aug 7;42(6):1075-1083. Epub 2018 Jan 7.

Department of Pediatrics, Cedars-Sinai Medical Center, Los Angeles, California, USA.

Background: Osmotic stress is a physical risk factor for adverse events related to peripheral parenteral nutrition (PN) administration, such as infiltration. We sought to improve prediction of compounded PN osmolality utilizing basic nutrient solutions available to North American neonatal intensive care units. This study tested the hypothesis that calculated osmolarity underestimates osmolality in compounded PN. Read More

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August 2018
1 Read

Glycemic Effects of a Low-Carbohydrate Enteral Formula Compared With an Enteral Formula of Standard Composition in Critically Ill Patients: An Open-Label Randomized Controlled Clinical Trial.

JPEN J Parenter Enteral Nutr 2018 Aug 27;42(6):1035-1045. Epub 2017 Dec 27.

Department of Intensive Care, OLVG, Amsterdam, the Netherlands.

Background: Enteral low-carbohydrate formulas (LCFs) could serve as a noninsulin alternative for the treatment of stress hyperglycemia in critically ill patients. We compared the glycemic effects of an LCF with a standard formula.

Methods: We conducted an open-label randomized trial in patients admitted to our intensive care unit between September 2015 and June 2016. Read More

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August 2018
7 Reads

JPEN Journal Club 37. Placebos and Nocebos.

Authors:
Ronald L Koretz

JPEN J Parenter Enteral Nutr 2018 Sep 17;42(7):1211-1213. Epub 2018 Aug 17.

Olive View-UCLA Medical Center, David Geffen-UCLA School of Medicine, Sylmar and Los Angeles, California, USA.

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September 2018