4,755 results match your criteria JPEN: Journal of Parenteral and Enteral Nutrition [Journal]


Vitamin D Supplementation in Mechanically Ventilated Patients in the Medical Intensive Care Unit.

JPEN J Parenter Enteral Nutr 2019 Feb 12. Epub 2019 Feb 12.

Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of Vermont Medical Center and Larner College of Medicine, Burlington, Vermont, USA.

Background: The utility of vitamin D (VITD) supplementation during critical illness and whether it may alter outcomes, including mortality and ventilator-free days, is unclear. We performed a retrospective cohort study in a generalizable population to investigate this question.

Methods: We included all mechanically ventilated adults admitted to the medical intensive care unit (ICU) service at a tertiary center from 2009 to 2012 who were in the ICU for at least 72 hours. Read More

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http://dx.doi.org/10.1002/jpen.1520DOI Listing
February 2019

Use of Concentrated Parenteral Nutrition Solutions Is Associated With Improved Nutrient Intakes and Postnatal Growth in Very Low-Birth-Weight Infants.

JPEN J Parenter Enteral Nutr 2019 Feb 12. Epub 2019 Feb 12.

Department of Clinical Sciences, Pediatrics, Umeå University, Umeå, Sweden.

Background: Evidence showing the beneficial effects of enhanced parenteral nutrition (PN) to very low-birth-weight (VLBW, <1500 g) infants is accumulating. However, PN composition and its impact on growth outcomes are questioned. This study aimed to investigate the associations between administration of a concentrated PN regime and intakes of energy and macronutrients as well as postnatal growth in VLBW infants. Read More

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http://doi.wiley.com/10.1002/jpen.1522
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http://dx.doi.org/10.1002/jpen.1522DOI Listing
February 2019
1 Read

PEP uP (Enhanced Protein-Energy Provision via the Enteral Route Feeding Protocol) in Surgical Patients-A Multicenter Pilot Randomized Controlled Trial.

JPEN J Parenter Enteral Nutr 2019 Feb 11. Epub 2019 Feb 11.

Clinical Evaluation Research Unit, Kingston General Hospital, Department of Critical Care, Queen's University, Kingston, Ontario, Canada.

Background: The Enhanced Protein-Energy Provision via the Enteral Route Feeding Protocol (PEP uP) has been shown to be feasible, safe, and effective in delivering significantly more energy/protein, though it has not been well studied in surgical/trauma patients. We hypothesized that PEP uP will effectively increase energy/protein delivery to critically ill surgical/trauma patients.

Methods: This multicenter, prospective, randomized pilot study included adult patients admitted to surgical service who were expected to require mechanical ventilation for >24 hours and intensive care unit (ICU) care for >72 hours. Read More

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http://doi.wiley.com/10.1002/jpen.1521
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http://dx.doi.org/10.1002/jpen.1521DOI Listing
February 2019
1 Read

Influence of Methods Used to Establish Sarcopenia Cutoff Values for Skeletal Muscle Measures Using Unenhanced and Contrast-Enhanced Computed Tomography Images.

JPEN J Parenter Enteral Nutr 2019 Feb 11. Epub 2019 Feb 11.

Department of Radiology, Third Xiangya Hospital of Central South University, Changsha, China.

Background: Multiple cutoff values of computed tomography (CT)-based skeletal muscle measures have been proposed, but there is currently no consensus used to identify sarcopenia. We aimed to evaluate the influence of statistical methods used to establish sarcopenia cutoff values and to examine the impact of contrast enhancement on the skeletal muscle measures.

Methods: The skeletal muscle area (SMA) and muscle radiation attenuation (MRA) of 316 healthy individuals were measured on unenhanced CT images at the third lumbar vertebra level, and the skeletal muscle index (SMI) was SMA divided by height squared. Read More

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http://dx.doi.org/10.1002/jpen.1519DOI Listing
February 2019
3.151 Impact Factor

JPEN Journal Club 43. Stratification.

Authors:
Ronald L Koretz

JPEN J Parenter Enteral Nutr 2019 Feb 7. Epub 2019 Feb 7.

Olive View-UCLA Medical Center, David Geffen-UCLA School of Medicine, Sylmar and Los Angeles, California, USA.

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http://dx.doi.org/10.1002/jpen.1523DOI Listing
February 2019

High Branched-Chain Amino Acid Concentrations Are Found in Preterm Baboons Receiving Intravenous Amino Acid Solutions and Mimic Alterations Found in Preterm Infants.

JPEN J Parenter Enteral Nutr 2019 Feb 7. Epub 2019 Feb 7.

Texas Pregnancy and Life-course Health Research Center, Department of Animal Science, University of Wyoming, Laramie, Wyoming, USA.

Background: Parenteral amino acid (AA) nutrition administration after premature birth is necessary to ensure adequate growth and neurodevelopment. However, optimizing safety and efficacy remains a major challenge. This study investigated the effects of intravenous AA administration on plasma AA profiles in premature baboons and infants. Read More

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http://dx.doi.org/10.1002/jpen.1507DOI Listing
February 2019

Cross-sectional Evaluation of Home Enteral Nutrition Practice in the United States in the Context of the New Enteral Connectors.

JPEN J Parenter Enteral Nutr 2019 Feb 7. Epub 2019 Feb 7.

Division of Endocrinology, Diabetes, Metabolism and Nutrition, Mayo Clinic, Rochester, Minnesota, USA.

Purpose: The increased prevalence of home enteral nutrition (HEN), reemergence of blenderized tube feeding (BTF), and conversion of enteral connectors to the ISO 80369-3 standard are creating a significant need to better understand the practices of the HEN population. A cross-sectional survey of current HEN consumers was conducted to evaluate the demographics of HEN consumers, including formulas and feeding tubes being used.

Methods: In order to disseminate the survey to a wide range of HEN consumers, we partnered with private infusion companies (Coram and Pediatric Home Services) along with the Oley and Tube Feeding Awareness Foundations. Read More

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http://dx.doi.org/10.1002/jpen.1510DOI Listing
February 2019

JPEN Journal Club 42. Factorial Design.

Authors:
Ronald L Koretz

JPEN J Parenter Enteral Nutr 2019 Feb 4. Epub 2019 Feb 4.

Olive View-UCLA Medical Center, David Geffen-UCLA School of Medicine, Sylmar and Los Angeles, California, USA.

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http://doi.wiley.com/10.1002/jpen.1509
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http://dx.doi.org/10.1002/jpen.1509DOI Listing
February 2019
3 Reads

Antecedent Administration of Glutamine Benefits the Homeostasis of CD4 T Cells and Attenuates Lung Injury in Mice With Gut-Derived Polymicrobial Sepsis.

JPEN J Parenter Enteral Nutr 2019 Feb 4. Epub 2019 Feb 4.

Department of Surgery, National Taiwan University Hospital and College of Medicine, National Taiwan University, Taipei, Taiwan.

Background: Sepsis is a syndrome with CD4 T-cell dysfunction and dysregulation of T helper (Th) and regulatory T (Treg) cells. Glutamine (Gln) is a nutrient with immunomodulatory properties. This study investigated the effects of dietary Gln pretreatment on Th and Treg cell homeostasis and lung injury in mice with gut-derived polymicrobial sepsis. Read More

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http://dx.doi.org/10.1002/jpen.1505DOI Listing
February 2019

Assessing Patient Preferences for Intestinal Failure Management Using the Time Trade-Off Methodology.

JPEN J Parenter Enteral Nutr 2019 Feb 4. Epub 2019 Feb 4.

Royal Prince Alfred Hospital, Sydney, Australia.

Background: There are limited management options available for people with Type III intestinal failure (IF), with home parenteral nutrition (HPN) being the main treatment option. The aim of this research is to compare patient preferences in managing Type III IF using time trade-off (TTO) methodology and to determine which factors have the greatest impact on health-related quality of life (HRQoL).

Methods: An interviewer-administered telephone survey was conducted on a cross-sectional cohort of 19 HPN participants. Read More

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http://dx.doi.org/10.1002/jpen.1506DOI Listing
February 2019

Prevalence of Malnutrition Risk and the Impact of Nutrition Risk on Hospital Outcomes: Results From nutritionDay in the U.S.

JPEN J Parenter Enteral Nutr 2019 Jan 22. Epub 2019 Jan 22.

Division Cardiac, Thoracic, and Vascular Anaesthesia and Intensive Care, Medical University Vienna, Vienna, Austria.

Background: Malnutrition risk estimates vary greatly, and no robust data on the association between food intake and outcomes exist for hospitals in the United States (U.S.). Read More

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http://dx.doi.org/10.1002/jpen.1499DOI Listing
January 2019
2 Reads

JPEN Journal Club 41. Propensity Scoring.

Authors:
Ronald L Koretz

JPEN J Parenter Enteral Nutr 2019 Jan 15. Epub 2019 Jan 15.

Olive View-UCLA Medical Center, David Geffen-UCLA School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.

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http://dx.doi.org/10.1002/jpen.1501DOI Listing
January 2019
2 Reads

Pilot Study of the Effect of Plant-Based Enteral Nutrition on the Gut Microbiota in Chronically Ill Tube-Fed Children.

JPEN J Parenter Enteral Nutr 2019 Jan 15. Epub 2019 Jan 15.

Department of Surgery, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania, USA.

Background: Dietary intake sharply impacts the structure and function of the gut microbiota, which is important for childhood health. However, little is known about the microbiota of children who cannot eat by mouth. Standard enteral formulas for supplemental nutrition are low in fiber and high in processed sugars and are commonly associated with gastrointestinal side effects. Read More

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http://dx.doi.org/10.1002/jpen.1504DOI Listing
January 2019

Novel Long-Acting GLP-2 Analogue, FE 203799 (Apraglutide), Enhances Adaptation and Linear Intestinal Growth in a Neonatal Piglet Model of Short Bowel Syndrome with Total Resection of the Ileum.

JPEN J Parenter Enteral Nutr 2019 Jan 6. Epub 2019 Jan 6.

Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.

Background: Glucagon-like peptide-2 (GLP-2) is an intestinotrophic factor released from L-cells in the ileum, a segment commonly resected or atretic in neonatal short bowel syndrome (SBS). In piglets, ileal resection decreases intestinal adaptation and endogenous GLP-2 production, whereas exogenous replacement promotes adaptation. In this study, we determined the effect of a novel long-acting GLP-2 analogue, FE 203799 (FE; apraglutide), upon intestinal growth, adaptation, and function in neonatal SBS piglets without ileum. Read More

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http://doi.wiley.com/10.1002/jpen.1500
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http://dx.doi.org/10.1002/jpen.1500DOI Listing
January 2019
12 Reads

Enteral Docosahexaenoic Acid and Retinopathy of Prematurity: A Randomized Clinical Trial.

JPEN J Parenter Enteral Nutr 2019 Jan 6. Epub 2019 Jan 6.

División de Pediatría, Hospital de Gineco-Obstetricia No.3, Centro Médico Nacional La Raza, Instituto Mexicano del Seguro Social, Ciudad de México, México.

Background: Retinopathy of prematurity (ROP) is a disorder of the retina of low-birth-weight preterm infants that potentially leads to blindness. Docosahexaenoic acid (DHA), is protective in experimental models, but its administration as part of parenteral nutrition has shown inconsistent results. We test the effect of enteral DHA to prevent ROP and/or severity and to reduce hospital stay. Read More

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http://dx.doi.org/10.1002/jpen.1497DOI Listing
January 2019

Effect of Early Parenteral Nutrition Discontinuation on Time to Regain Birth Weight in Very Low Birth Weight Infants: A Randomized Controlled Trial.

JPEN J Parenter Enteral Nutr 2019 Jan 6. Epub 2019 Jan 6.

Coombe Women and Infants University Hospital, Dublin, Ireland.

Background: Peripherally inserted central catheters (PICCs) are used to administer parenteral nutrition (PN) in very low birth weight infants (VLBW; <1500 g). Clinicians try to optimize early nutrition but also minimize the risks associated with intravascular devices. The objective of this study was to examine the early nutrition impact of discontinuing PN at different enteral feed volumes in VLBW infants. Read More

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http://doi.wiley.com/10.1002/jpen.1502
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http://dx.doi.org/10.1002/jpen.1502DOI Listing
January 2019
5 Reads

Milk Fat Globule Membrane Ameliorates Necrotizing Enterocolitis in Neonatal Rats and Suppresses Lipopolysaccharide-Induced Inflammatory Response in IEC-6 Enterocytes.

JPEN J Parenter Enteral Nutr 2019 Jan 6. Epub 2019 Jan 6.

Shanghai Institute for Pediatric Research, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Background: Evidence has provided support for the beneficial effects of milk fat globule membrane (MFGM) on inflammation in the intestinal tract. The objective of this study was to investigate the effects of MFGM on a rat model of necrotizing enterocolitis (NEC) and its potential mechanism of action.

Methods: Sixty-two newborn Sprague Dawley rats were randomly divided into 4 experimental groups: Breast-fed normal, formula fed (FF), FF + 6 g/L MFGM, and FF + 12 g/L MFGM. Read More

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http://dx.doi.org/10.1002/jpen.1496DOI Listing
January 2019

Priorities for Nutrition Research in Pediatric Critical Care.

JPEN J Parenter Enteral Nutr 2018 Dec 26. Epub 2018 Dec 26.

Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Background: Widespread variation exists in pediatric critical care nutrition practices, largely because of the scarcity of evidence to guide best practice recommendations.

Objective: The objective of this paper was to develop a list of topics to be prioritized for nutrition research in pediatric critical care in the next 10 years.

Methods: A modified 3-round Delphi process was undertaken by a newly established multidisciplinary group comprising 11 international researchers in the field of pediatric critical care nutrition. Read More

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http://doi.wiley.com/10.1002/jpen.1498
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http://dx.doi.org/10.1002/jpen.1498DOI Listing
December 2018
14 Reads

Successful Management of Ketogenic Parenteral Nutrition: A Pediatric Case Study.

JPEN J Parenter Enteral Nutr 2018 Dec 20. Epub 2018 Dec 20.

Division of Neurology, The Hospital for Sick Children, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/jpen.1490DOI Listing
December 2018
1 Read

Bolus vs Continuous Nasogastric Feeds in Mechanically Ventilated Pediatric Patients: A Pilot Study.

JPEN J Parenter Enteral Nutr 2018 Dec 20. Epub 2018 Dec 20.

Pediatric Intensive Care Unit, Akron Children's Hospital, Akron, Ohio, USA.

Background: Malnutrition increases the risk of mortality and morbidity in the pediatric intensive care unit (PICU). Barriers to adequate delivery of enteral nutrition (EN) include hemodynamic instability, feeding interruptions and intolerance, and lack of standardized feeding protocols. The most recent guidelines on nutrition support for the critically ill child describe a paucity of evidence around the best method to deliver EN. Read More

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http://dx.doi.org/10.1002/jpen.1495DOI Listing
December 2018

Specialized High-Protein Oral Nutrition Supplement Improves Home Nutrient Intake of Malnourished Older Adults Without Decreasing Usual Food Intake.

JPEN J Parenter Enteral Nutr 2018 Nov 22. Epub 2018 Nov 22.

Brody School of Medicine, East Carolina University, Greenville, North Carolina, USA.

Background: Reduced nutrient intake is common in patients after hospitalization, contributing to increased risk for readmission and mortality. Oral nutrition supplements can improve nutrition status and clinical outcomes, but intake of food is prioritized by clinicians. This study examines the impact of a high-protein oral nutrition supplement (S-ONS) on nutrient intake post discharge. Read More

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http://dx.doi.org/10.1002/jpen.1467DOI Listing
November 2018

Factors Associated With Use of Nonoral Nutrition and Hydration Support in Adult Patients With Postural Tachycardia Syndrome.

JPEN J Parenter Enteral Nutr 2018 Dec 18. Epub 2018 Dec 18.

Division of Gastroenterology and Hepatology, Mayo Clinic, Scottsdale, Arizona, USA.

Background: Patients with postural tachycardia syndrome (POTS) often have gastrointestinal (GI) symptoms. Occasionally, these symptoms can be so severe that nonoral nutrition/hydration support (NONHS), including intravenous fluids (IVFs), enteral nutrition (EN), and parenteral nutrition (PN), becomes necessary.

Methods: This is a retrospective cohort study of adult patients diagnosed with POTS at the Mayo Clinic Arizona from January 2010 to January 2017 with a minimum of 6 months of follow up. Read More

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http://doi.wiley.com/10.1002/jpen.1493
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http://dx.doi.org/10.1002/jpen.1493DOI Listing
December 2018
6 Reads

Sarcopenia Index Is a Simple Objective Screening Tool for Malnutrition in the Critically Ill.

JPEN J Parenter Enteral Nutr 2018 Dec 18. Epub 2018 Dec 18.

Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, Minnesota, USA.

Background: Reliable and valid tools to screen for malnutrition in the intensive care unit (ICU) remain elusive. The sarcopenia index (SI) [(serum creatinine/serum cystatin C) × 100], could be an inexpensive, objective tool to predict malnutrition. We evaluated the SI as a screening tool for malnutrition in the ICU and compared it with the modified-NUTRIC score. Read More

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http://dx.doi.org/10.1002/jpen.1492DOI Listing
December 2018
1 Read

Effect of Psyllium Fiber Supplementation on Diarrhea Incidence in Enteral Tube-Fed Patients: A Prospective, Randomized, and Controlled Trial.

JPEN J Parenter Enteral Nutr 2018 Dec 18. Epub 2018 Dec 18.

Department of Internal Medicine, Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand.

Background: Diarrhea in enteral tube-fed patients is not uncommon and can lead to unfavorable outcomes. Fiber in enteral nutrition (EN) formula might play a role in postfeeding diarrhea. Theoretically, soluble fiber is beneficial for both prevention and treatment of postfeeding diarrhea, but different types of soluble fiber may not provide the same effect. Read More

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http://dx.doi.org/10.1002/jpen.1489DOI Listing
December 2018

Foundational Issue in Nutrition.

Authors:
David A August

JPEN J Parenter Enteral Nutr 2018 Dec 18. Epub 2018 Dec 18.

Associate Director for Faculty Affairs, Rutgers Cancer Institute of New Jersey, Professor of Surgery, Rutgers Robert Wood Johnson Medical School, Piscataway Township, New Jersey, USA.

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http://dx.doi.org/10.1002/jpen.1491DOI Listing
December 2018

Incidence and Effects of Feeding Intolerance in Trauma Patients.

JPEN J Parenter Enteral Nutr 2018 Dec 3. Epub 2018 Dec 3.

Department of Medical Chemistry, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.

Background: Although feeding intolerance is a common complication in trauma patients, the incidence, development, and effects are poorly understood.

Methods: We performed a retrospective study in which trauma patients were classified as having feeding intolerance based on time to reach feeding goal. Subsequently, we sorted patients by gastric residual volumes (GRVs) or symptoms of slowed gastrointestinal motility. Read More

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http://doi.wiley.com/10.1002/jpen.1469
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http://dx.doi.org/10.1002/jpen.1469DOI Listing
December 2018
13 Reads

Prediction of Prolonged ICU Stay in Cardiac Surgery Patients as a Useful Method to Identify Nutrition Risk in Cardiac Surgery Patients: A Post Hoc Analysis of a Prospective Observational Study.

JPEN J Parenter Enteral Nutr 2018 Dec 2. Epub 2018 Dec 2.

Clinical Evaluation Research Unit, Kingston General Hospital, Kingston, Ontario, Canada.

Background: Cardiovascular surgery patients with a prolonged intensive care unit (ICU) stay may benefit most from early nutrition support. Using established scoring systems for nutrition assessment and operative risk stratification, we aimed to develop a model to predict a prolonged ICU stay ≥5 days in order to identify patients who will benefit from early nutrition interventions.

Methods: This is a retrospective analysis of a prospective observational study of patients undergoing elective valvular, coronary artery bypass grafting, or combined cardiac surgery. Read More

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http://doi.wiley.com/10.1002/jpen.1486
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http://dx.doi.org/10.1002/jpen.1486DOI Listing
December 2018
7 Reads

Editorial Effort for the EFFORT Trial Manuscript Was Worth the Effort.

Authors:
David A August

JPEN J Parenter Enteral Nutr 2018 Nov 29. Epub 2018 Nov 29.

Rutgers Cancer Institute of New Jersey, Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.

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http://dx.doi.org/10.1002/jpen.1488DOI Listing
November 2018

Time to Full Enteral Feeding for Very Low-Birth-Weight Infants Varies Markedly Among Hospitals Worldwide But May Not Be Associated With Incidence of Necrotizing Enterocolitis: The NEOMUNE-NeoNutriNet Cohort Study.

JPEN J Parenter Enteral Nutr 2018 Nov 22. Epub 2018 Nov 22.

Department of Neonatology, Shenzhen Bao'an Maternal and Child Health Hospital, Shenzhen, China.

Background: Transition to enteral feeding is difficult for very low-birth-weight (VLBW; ≤1500 g) infants, and optimal nutrition is important for clinical outcomes.

Method: Data on feeding practices and short-term clinical outcomes (growth, necrotizing enterocolitis [NEC], mortality) in VLBW infants were collected from 13 neonatal intensive care units (NICUs) in 5 continents (n = 2947). Specifically, 5 NICUs in Guangdong province in China (GD), mainly using formula feeding and slow feeding advancement (n = 1366), were compared with the remaining NICUs (non-GD, n = 1581, Oceania, Europe, United States, Taiwan, Africa) using mainly human milk with faster advancement rates. Read More

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http://dx.doi.org/10.1002/jpen.1466DOI Listing
November 2018
12 Reads
3.151 Impact Factor

Factors Related to the Assessment of Resting Metabolic Rate in Critically Ill Patients.

JPEN J Parenter Enteral Nutr 2019 Feb 21;43(2):234-244. Epub 2018 Nov 21.

Department of Clinical Nutrition, Penn State Health, Milton S. Hershey Medical Center, Hershey, Pennsylvania, USA.

Background: Predicting resting metabolic rate (RMR) in mechanically ventilated, critically ill patients is an important part of the nutrition care in such patients.

Methods: RMR and associated clinical data from various studies of mechanically ventilated, critically ill patients were combined, and the impact of body size, age, reason for admission, and sedation level were analyzed along with prediction methods of RMR (the American Society for Parenteral and Enteral Nutrition [ASPEN] standards and the Penn State equation).

Results: Among 826 measurements, trauma patients had a higher RMR than surgical and medical patients (2077 ± 290 vs 1987 ± 282 kcal/d; P < . Read More

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http://dx.doi.org/10.1002/jpen.1484DOI Listing
February 2019
11 Reads

Prevalence, Characteristics, and Outcome of Cow's Milk Protein Allergy in Chinese Infants: A Population-Based Survey.

JPEN J Parenter Enteral Nutr 2018 Nov 19. Epub 2018 Nov 19.

Department of Gastroenterology, Guangzhou Women and Children's Medical Center of Guangzhou Medical University, Guangzhou, China.

Background: Cow's milk protein allergy (CMPA) is commonly seen in children. There have been no reports of the true prevalence of CMPA in Chinese infants. The aim of this population-based study is to determine the prevalence, clinical characteristics, and outcome of CMPA in Chinese infants. Read More

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http://dx.doi.org/10.1002/jpen.1472DOI Listing
November 2018
18 Reads
3.151 Impact Factor

Effects of Nutrition Supplementation on Osmolality of Expressed Human Milk.

JPEN J Parenter Enteral Nutr 2018 Nov 19. Epub 2018 Nov 19.

Cohen Children's Medical Center, Northwell Health, New Hyde Park, New York, USA.

Background: Provision of human milk to premature infants optimizes outcomes, but it must be supplemented to meet their nutrient and caloric requirements for growth. Our objective was to quantify the osmolality of human milk mixed with commercially available human milk fortifiers (HMF) and powdered infant formula, as currently fed to premature infants, simulating standard neonatal intensive care unit feeding practices for mixing and refrigerator storage.

Methods: Expressed human milk (EHM) samples obtained from mothers of premature infants (≤32 weeks gestation) were mixed with standard commercial products, and osmolalities were quantified. Read More

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http://doi.wiley.com/10.1002/jpen.1470
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http://dx.doi.org/10.1002/jpen.1470DOI Listing
November 2018
12 Reads

Vitamin C Administration to the Critically Ill: A Systematic Review and Meta-Analysis.

JPEN J Parenter Enteral Nutr 2018 Nov 19. Epub 2018 Nov 19.

Clinical Evaluation Research Unit, Kingston General Hospital, Kingston, Ontario, Canada and Department of Critical Care, Queen's University, Kingston, Ontario, Canada.

Vitamin C, an enzyme cofactor and antioxidant, could hasten the resolution of inflammation, oxidative stress, and microvascular dysfunction. While observational studies have demonstrated that critical illness is associated with low levels of vitamin C, randomized controlled trials (RCTs) of vitamin C, alone or in combination with other antioxidants, have yielded contradicting results. We searched MEDLINE, EMBASE, CINAHL, and the Cochrane Central Register of Controlled Trials (inception to December 2017) for RCTs comparing vitamin C, by enteral or parenteral routes, with placebo or none, in intensive care unit (ICU) patients. Read More

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http://doi.wiley.com/10.1002/jpen.1471
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http://dx.doi.org/10.1002/jpen.1471DOI Listing
November 2018
17 Reads

Standardized Nutrition Protocol for Very Low-Birth-Weight Infants Resulted in Less Use of Parenteral Nutrition and Associated Complications, Better Growth, and Lower Rates of Necrotizing Enterocolitis.

JPEN J Parenter Enteral Nutr 2018 Nov 9. Epub 2018 Nov 9.

Division of Neonatology, Hassenfeld Children's Hospital at NYU Langone, New York University School of Medicine, New York, New York, USA.

Background: We assessed the impact of a standardized nutrition initiative for very low-birth-weight (VLBW) infants on their nutrition and clinical outcomes.

Methods: This was a prospective analysis of VLBW infants born before and after the initiation of a nutrition protocol. This protocol included trophic feeds, feeding advancement, fortification guidelines, parameters on the concentration of parenteral nutrition (PN), and the discontinuation of PN and central lines. Read More

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http://doi.wiley.com/10.1002/jpen.1453
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http://dx.doi.org/10.1002/jpen.1453DOI Listing
November 2018
10 Reads

Addition of Insulin to Parenteral Nutrition Is Not Universally Safe.

JPEN J Parenter Enteral Nutr 2019 Jan 8;43(1):13. Epub 2018 Nov 8.

Division of Human Nutrition, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, Western Cape, South Africa.

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http://doi.wiley.com/10.1002/jpen.1465
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http://dx.doi.org/10.1002/jpen.1465DOI Listing
January 2019
1 Read

Long-Term Outcomes in Children With Intestinal Failure-Associated Liver Disease Treated With 6 Months of Intravenous Fish Oil Followed by Resumption of Intravenous Soybean Oil.

JPEN J Parenter Enteral Nutr 2018 Nov 8. Epub 2018 Nov 8.

Department of Pediatrics, Division of Neonatology, David Geffen School of Medicine, University of California, Los Angeles, California.

Background: Intravenous soybean oil (SO) is a commonly used lipid emulsion for children with intestinal failure (IF); however, it is associated with IF-associated liver disease (IFALD). Studies have demonstrated that intravenous fish oil (FO) is an effective treatment for IFALD. However, there is a lack of long-term data on children who stop FO and resume SO. Read More

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http://doi.wiley.com/10.1002/jpen.1463
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http://dx.doi.org/10.1002/jpen.1463DOI Listing
November 2018

JPEN Journal Club 40. Differences in Nominal Significance.

Authors:
Ronald L Koretz

JPEN J Parenter Enteral Nutr 2019 Feb 8;43(2):311-313. Epub 2018 Nov 8.

Olive View-UCLA Medical Center, David Geffen-UCLA School of Medicine, Sylmar and Los Angeles, California, USA.

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http://dx.doi.org/10.1002/jpen.1473DOI Listing
February 2019

Author Response to "Addition of Insulin to Parenteral Nutrition Is Not Universally Safe".

JPEN J Parenter Enteral Nutr 2019 Jan 8;43(1):14. Epub 2018 Nov 8.

Cambridge Intestinal Failure and Transplant, Addenbrooke's Hospital, Cambridge, UK.

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http://dx.doi.org/10.1002/jpen.1464DOI Listing
January 2019
1 Read

Characterizing Exclusively Breastfed Infant Stool via a Novel Infant Stool Scale.

JPEN J Parenter Enteral Nutr 2018 Nov 29;42 Suppl 1:S5-S11. Epub 2018 Oct 29.

Procter & Gamble Company, Cincinnati, Ohio, USA.

Analysis of stool has long been a diagnostic tool across a number of disease states. Currently, there are two stool scales in clinical use, the Bristol Stool Scale and the Amsterdam Infant Stool Scale. However, the existing categorizations for stool may not sufficiently cover the broad range of stool output for exclusively breastfed infants. Read More

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http://dx.doi.org/10.1002/jpen.1468DOI Listing
November 2018

Citrulline Generation Test: What Does It Measure?

JPEN J Parenter Enteral Nutr 2018 Oct 24. Epub 2018 Oct 24.

USDA/ARS Children's Nutrition Research Center, Baylor College of Medicine, Houston, Texas, USA.

Background: The citrulline generation test (CGT) has been proposed as a tool to determine gut function. However, the increase in plasma citrulline concentration that follows a bolus dose of alanyl-glutamine may also result from a reduction in citrulline clearance due to competition with glutamine for transport.

Materials And Methods: A swine model was developed, and stable isotope tracers were used to determine the mechanism behind the increase in plasma citrulline that follows a bolus dose of alanyl-glutamine. Read More

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http://doi.wiley.com/10.1002/jpen.1462
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http://dx.doi.org/10.1002/jpen.1462DOI Listing
October 2018
10 Reads

Dietary Management of Propionic Acidemia: Parent Caregiver Perspectives and Practices.

JPEN J Parenter Enteral Nutr 2018 Oct 24. Epub 2018 Oct 24.

Social and Behavioral Research Branch, Social Network Methods Section, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA.

Background: Propionic acidemia (PA), an autosomal recessive metabolic disorder, has an estimated incidence of 1:105,000-130,000 in the United States. Nutrition management is a main intervention for PA. Research in inborn errors of metabolism such as phenylketonuria has identified association of parental perceptions and practices with dietary outcomes. Read More

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http://dx.doi.org/10.1002/jpen.1461DOI Listing
October 2018
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Overnight Steady-State Infusions of Parenteral Nutrition on Myosin Heavy Chain Transcripts in Rectus Abdominis Muscle Related to Amino Acid Transporters, Insulin-like Growth Factor 1, and Blood Amino Acids in Patients Aimed at Major Surgery.

JPEN J Parenter Enteral Nutr 2018 Oct 22. Epub 2018 Oct 22.

Surgical Metabolic Research Lab, Department of Surgery, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Sweden.

Background: Evaluation of improvements by nutrition support to severely ill patients requires sensitive methods to demonstrate activation of protein synthesis in various tissues from groups with a limited number of patients to be statistically efficient. This study examines effects of standard parenteral nutrition (PN) on abdominal muscle transcripts of amino acid (AA) transporters, myosin heavy chains (MHCs), and the insulin-like growth factor 1 and its receptor (IGF-1/IGF-1R) in patients aimed at major surgery.

Methods: Twenty-two randomized patients received steady-state PN (0. Read More

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http://dx.doi.org/10.1002/jpen.1458DOI Listing
October 2018

Vitamin C Status in Hospitalized Adults According to Subjective Global Assessment Method.

JPEN J Parenter Enteral Nutr 2018 Oct 22. Epub 2018 Oct 22.

Department of Internal Medicine, Federal University of Triângulo Mineiro, Uberaba/MG, Brazil.

Background: The subjective global assessment (SGA) is a powerful tool for nutrition status assessment. Our aim was to compare vitamin C serum levels among patients classified as A, B, or C in the SGA.

Methods: One hundred-and-fifty adults in the wards of the University Hospital participated in this study. Read More

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http://doi.wiley.com/10.1002/jpen.1460
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http://dx.doi.org/10.1002/jpen.1460DOI Listing
October 2018
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American Society for Parenteral and Enteral Nutrition Guidelines for the Selection and Care of Central Venous Access Devices for Adult Home Parenteral Nutrition Administration.

JPEN J Parenter Enteral Nutr 2019 Jan 19;43(1):15-31. Epub 2018 Oct 19.

Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago Illinois.

This document represents the American Society for Parenteral and Enteral Nutrition (ASPEN) clinical guidelines to describe best practices in the selection and care of central venous access devices (CVADs) for the infusion of home parenteral nutrition (HPN) admixtures in adult patients. The guidelines targeted adults >18 years of age in which the intervention or exposure had to include HPN that was administered via a CVAD. Case studies, non-English studies, or studies of CVAD no longer available in the United States were excluded. Read More

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http://dx.doi.org/10.1002/jpen.1455DOI Listing
January 2019

Close Relationship Between Immunological/Inflammatory Markers and Myopenia and Myosteatosis in Patients With Colorectal Cancer: A Propensity Score Matching Analysis.

JPEN J Parenter Enteral Nutr 2018 Oct 18. Epub 2018 Oct 18.

Department of Gastrointestinal and Pediatric Surgery, Division of Reparative Medicine, Institute of Life Sciences, Mie University Graduate School of Medicine, Mie, Japan.

Background: The systemic inflammatory response (SIR) via host-tumor interactions has been termed the seventh hallmark of cancer, and several studies demonstrated that SIR might be a pivotal mediator for progression of cancer cachexia. The objective of this study was to clarify the correlation between sarcopenia and SIR in patients with colorectal cancer (CRC).

Methods: A total of 308 patients with CRC were enrolled in this study. Read More

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http://dx.doi.org/10.1002/jpen.1459DOI Listing
October 2018

Preoperative Oral Branched-Chain Amino Acid Supplementation Suppresses Intraoperative and Postoperative Blood Lactate Levels in Patients Undergoing Major Hepatectomy.

JPEN J Parenter Enteral Nutr 2019 Feb 18;43(2):220-225. Epub 2018 Oct 18.

Division of Hepato-biliary-pancreatic Surgery, Department of Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.

Background: Lactate production is exacerbated by surgical stress. We sought to determine whether branched-chain amino acid (BCAA) supplementation could decrease blood lactate levels in patients undergoing hepatectomy.

Methods: A total of 275 consecutive patients who underwent hepatectomy of ≥2 segments were retrospectively reviewed. Read More

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http://dx.doi.org/10.1002/jpen.1445DOI Listing
February 2019

AGREEing on Guidelines for Nutrition Management of Adult Severe Burn Patients.

JPEN J Parenter Enteral Nutr 2018 Oct 15. Epub 2018 Oct 15.

Department of Rheumatology and Clinical Immunology, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece.

Background: Severe burns are associated with a plethora of profound metabolic, immunologic, and physiologic responses, demanding prompt and adequate management. The objective of the present study was to review, compare, and critically appraise medical nutrition therapy guidelines for adult patients with severe burns, and produce salient points for the future update of relevant guidelines.

Methods: A total of 8 clinical practice guidelines developed by the American Burn Association (ABA), the European Burn Association (EBA), the European Society for Parenteral and Enteral Nutrition (ESPEN), the Midlands National Health Service, the Society for Critical Care Medicine (SCCM)/American Society for Parenteral and Enteral Nutrition (ASPEN), the Spanish Society of Intensive Care Medicine and Coronary Units and Spanish Society of Parenteral and Enteral Nutrition, the Indian Association for Parenteral and Enteral Nutrition (IAPEN), and the International Society for Burn Injury regarding medical nutrition therapy in burn patients was independently reviewed by a team of 4 multidisciplinary researchers using the Appraisal of Guidelines for Research & Evaluation (AGREE II) instrument. Read More

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http://doi.wiley.com/10.1002/jpen.1452
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http://dx.doi.org/10.1002/jpen.1452DOI Listing
October 2018
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Poor Social Support and Unemployment Are Associated With Negative Affect in Home Parenteral Nutrition-Dependent Patients With Chronic Intestinal Failure.

JPEN J Parenter Enteral Nutr 2018 Oct 9. Epub 2018 Oct 9.

Intestinal Failure Unit, Salford Royal NHS Foundation Trust, Salford, United Kingdom.

Background: Home parenteral nutrition (HPN) provides life-sustaining treatment for people with chronic intestinal failure (CIF). Poor quality of life is reported in association with the burden of HPN and the underlying condition leading to intestinal failure (IF). However, levels of negative affect (NA), incorporating anxiety and depression, have not been reported in CIF. Read More

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http://doi.wiley.com/10.1002/jpen.1457
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http://dx.doi.org/10.1002/jpen.1457DOI Listing
October 2018
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JPEN Journal Club 39. Validating a Surrogate.

Authors:
Ronald L Koretz

JPEN J Parenter Enteral Nutr 2019 Jan 9;43(1):170-172. Epub 2018 Oct 9.

Olive View-UCLA Medical Center and the David Geffen-UCLA School of Medicine, Sylmar and Los Angeles, California, USA.

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http://dx.doi.org/10.1002/jpen.1456DOI Listing
January 2019

Hypoalbuminemia: Pathogenesis and Clinical Significance.

JPEN J Parenter Enteral Nutr 2019 Feb 4;43(2):181-193. Epub 2018 Oct 4.

Department of Clinical Chemistry, University of Liverpool, Liverpool, UK.

Hypoalbuminemia is associated with inflammation. Despite being addressed repeatedly in the literature, there is still confusion regarding its pathogenesis and clinical significance. Inflammation increases capillary permeability and escape of serum albumin, leading to expansion of interstitial space and increasing the distribution volume of albumin. Read More

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http://dx.doi.org/10.1002/jpen.1451DOI Listing
February 2019
9 Reads