3,932 results match your criteria JOP: Journal of the Pancreas[Journal]
J Oncol Pract 2018 Dec;14(12):e823-e833
Yale New Haven Hospital; Yale School of Medicine; Yale Cancer Center; Smilow Cancer Hospital; and Community Health Educators Group, New Haven, CT.
Purpose:: Many US academic centers have acquired community practices to expand their clinical care and research footprint. The objective of this assessment was to determine whether the acquisition and integration of community oncology practices by Yale/Smilow Cancer Hospital improved outcomes in quality of care, disease team integration, clinical trial accrual, and patient satisfaction at network practice sites.
Methods:: We evaluated quality of care by testing the hypothesis that core Quality Oncology Practice Initiative measures at network sites that were acquired in 2012 were significantly different after their 2016 integration into the network. Read More
J Oncol Pract 2018 Dec;14(12):e834-e843
Johns Hopkins Bloomberg School of Public Health; Johns Hopkins School of Medicine, Baltimore, MD; University of Cincinnati College of Medicine, Cincinnati, OH; Duke Cancer Institute and Duke Fuqua School of Business, Duke University, Durham, NC; Veterans Affairs Greater Los Angeles Health System, University of California, Los Angeles, Los Angeles; Stanford School of Medicine, Stanford, CA; Temmy Latner Centre for Palliative Care, Sinai Health System; University of Toronto; and Institute for Health Policy, Management, and Evaluation, University of Toronto, Toronto, Ontario, Canada.
Purpose:: To evaluate the reliability, content validity, and variation among sites of a survey to assess facilitators and barriers to quality measurement and improvement in palliative care programs.
Methods:: We surveyed a sample of diverse US and Canadian palliative care programs and conducted postcompletion discussion groups. The survey included constructs addressing educational support and training, communication, teamwork, leadership, and prioritization for quality measurement and improvement. Read More
J Oncol Pract 2018 Dec;14(12):761-762
City of Hope Medical Group, Duarte, CA.
J Oncol Pract 2018 Dec;14(12):e758-e769
Sarah Cannon Cancer Institutes at HCA Midwest Health, Overland Park, KS; University of Florida College of Medicine; Malcom Randall Veterans Affairs Medical Center, Gainesville; Florida Cancer Specialists, Deland, FL; University of Texas Southwestern Medical Center, Dallas, TX; and Cleveland Clinic Akron General, Akron, OH.
Purpose:: Meaningful connections are an important aspect of career satisfaction. The Hematology Oncology Women Physician Group (HOWPG) is a private Facebook (FB) group of 936 women who practice within the hematology/oncology (H/O) field. We hypothesized that HOWPG adds value to education, emotional wellness, and practice of oncology for its membership. Read More
J Oncol Pract 2018 Dec;14(12):701-708
South East Cancer Center, University Hospital Waterford, Waterford, Ireland; and Princess Margaret Cancer Centre, University of Toronto, Toronto, Ontario, Canada.
Biliary tract cancers, including gallbladder cancer, intrahepatic, perihilar, and distal cholangiocarcinomas, although anatomically contiguous, represent a heterogeneous group of cancers with extensive biologic and genetic diversity. With early disease, surgical resection is the preferred option for all subtypes; however, relapse rates remain high, and survival outcomes are poor. Data to guide the use of adjuvant therapy have been limited to retrospective series, population-based studies, and meta-analyses, all with their associated limitations. Read More
J Oncol Pract 2018 Dec;14(12):757-759
Duke Cancer Institute, Durham, NC; Princess Margaret Cancer Centre, Toronto, Ontario, Canada.
J Oncol Pract 2018 Dec;14(12):e775-e785
Memorial Sloan Kettering Cancer Center, New York, NY.
Background:: Prior work to integrate early palliative care in oncology has focused on patients with advanced cancer and primarily on palliative care consultation. We developed this outpatient clinic initiative for newly diagnosed patients at any stage, emphasizing primary (nonspecialist) palliative care by oncology teams, with enhanced access to palliative care specialists.
Methods:: We piloted the project in two medical oncology specialty clinics (for patients with myelodysplastic syndrome and GI cancer, respectively) to establish feasibility. Read More
J Oncol Pract 2018 Dec;14(12):e794-e800
Southlake Regional Health Centre, Newmarket; and University of Toronto, Toronto, Ontario, Canada.
Purpose:: Peer review of a proposed treatment plan is increasingly recognized as an important quality activity in radiation medicine. Although peer review has been emphasized in the curative setting, applying peer review for treatment plans that have palliative intent is receiving increased attention. This study reports peer review outcomes for a regional cancer center that applied routine interprofessional peer review as a standard practice for palliative radiotherapy. Read More
J Oncol Pract 2018 Dec;14(12):e815-e822
Beth Israel Deaconess Medical Center; Dana-Farber Cancer Institute; Partners HealthCare; and Massachusetts General Hospital, Boston, MA.
Purpose:: Training clinical and supportive staff in quality improvement (QI) theory and use of QI tools has the potential to improve oncology care delivery. We report our combined experience of providing training to oncologists in a variety of local settings and assess the effect of the training on individual participants and for institutions.
Methods:: Multidisciplinary oncology teams at a comprehensive cancer center, an academic medical center, and community practices were led through experiential QI training that spanned several months. Read More
J Oncol Pract 2018 Dec;14(12):763-766
Stanford University Cancer Institute, Stanford, CA.
J Oncol Pract 2018 Dec;14(12):e786-e793
Icahn School of Medicine at Mount Sinai, New York, NY; and The Everett Clinic, Providence Regional Medical Center, Everett, WA.
Purpose:: The Quality Oncology Practice Initiative (QOPI) is a quality measurement and improvement program designed to assess practice performance for various consensus-based and evidence-based measures. In this study, we evaluated differences in QOPI metrics met among patients with advanced solid cancer receiving routine oncologic care alone (routine care) compared with patients receiving integrated oncology and specialty-level palliative care (supportive care).
Methods:: We conducted a retrospective chart review of 100 randomly selected patients treated between June 2013 and June 2015 from our supportive care group and matched these patients to 100 routine care group patients on the basis of tumor type and initial oncology visit date. Read More
J Oncol Pract 2018 Dec;14(12):754-756
National University Health System, Singapore.
J Oncol Pract 2018 Dec;14(12):e801-e814
Fred Hutchinson Cancer Research Center, Seattle, WA; Premera Blue Cross, Mountlake Terrace, WA; and University of Washington School of Medicine, Seattle, WA.
Regional public reporting of performance measures in oncology can facilitate local decision making across stakeholders, but small numbers of patients and clinics pose a challenge to creating statistically robust measures. In this article, we describe our development of the Community Cancer Care in Washington State: Quality and Cost Report, the first publicly available report showing clinic-level quality and cost measures at the regional level. We learned key lessons in how to adapt national performance reporting to our regional setting using a registry-linked multipayer claims database. Read More
J Oncol Pract 2018 Dec;14(12):747-749
Inova Fairfax Hospital and Inova Schar Cancer Institute, Falls Church, VA; and Seoul National University Hospital, Seoul, Republic of Korea.
J Oncol Pract 2018 Dec;14(12):719-720
Center for Innovations in Quality, Effectiveness, and Safety at the Michael E. DeBakey VA Medical Center and Baylor College of Medicine, Houston, TX.
J Oncol Pract 2018 Dec;14(12):723-724
The Ohio State University Wexner Medical Center, Columbus, OH.
J Oncol Pract 2018 Dec 10:JOP1800289. Epub 2018 Dec 10.
UPMC Hillman Cancer Center; University of Pittsburgh School of Medicine, Pittsburgh, PA; Celgene Corporation, Summit, NJ; Columbia University Mailman School of Public Health, New York, NY; and Odonate Therapeutics, San Diego, CA.
J Oncol Pract 2018 Dec 7:JOP1800430. Epub 2018 Dec 7.
University of Pittsburgh School of Medicine, Pittsburgh, PA.
Purpose:: The 2018 American Society for Radiation Oncology guidelines state that hypofractionated whole-breast irradiation (HF-WBI) may be used for early-stage breast cancer regardless of age, although evidence to support this became available years ago. Before guideline publication, we sought to change the practice pattern within an integrated, comprehensive radiation oncology network using clinical pathways.
Methods:: The breast clinical pathway was amended in January 2016 to allow HF-WBI as a pathway-concordant option for women younger than 50 years of age. Read More
J Oncol Pract 2018 Dec 6:JOP1800613. Epub 2018 Dec 6.
Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands; American Society of Clinical Oncology, Alexandria, VA; and Moffitt Cancer Center, Tampa, FL.
J Oncol Pract 2018 Nov 29:JOP1800205. Epub 2018 Nov 29.
The University of Texas MD Anderson Cancer Center; and The University of Texas School of Public Health, Houston, TX; Oregon Health & Science University, Portland, OR; Kangwon National University Hospital, Kangwon; National University School of Medicine, Gangwon-do, Republic of Korea; and The Third Affiliated Hospital of the Kunming Medical University, Yunnan, China.
Purpose:: An understanding of opioid prescription and cost patterns is important to optimize pain management for patients with advanced cancer. This study aimed to determine opioid prescription and cost patterns and to identify opioid prescription predictors in patients with advanced cancer who received inpatient palliative care (IPC).
Materials And Methods:: We reviewed data from 807 consecutive patients with cancer who received IPC in each October from 2008 through 2014. Read More
J Oncol Pract 2018 Nov 29:JOP1800522. Epub 2018 Nov 29.
National Cancer Institute, Rockland, MD; ICF, Fairfax, VA; and University of Alabama at Birmingham, Birmingham, AL.
Purpose:: We examined associations between caregiving intensity and mental health among cancer caregivers at the population level and potential moderation by an actionable intervention target, support service needs.
Methods:: Behavioral Risk Factors Surveillance System survey data (2015) from caregivers of adult patients with cancer was analyzed. Caregiving intensity included hours per week caregiving (high, > 20; low, ≤ 20) and caregiving duration (long, > 2 years; short, ≤ 2 years). Read More
J Oncol Pract 2018 Nov 16:JOP1800331. Epub 2018 Nov 16.
Stanford University School of Medicine, Stanford; Veterans Affairs Palo Alto Health Care System, Palo Alto, CA; and University of Washington, Seattle, WA.
Introduction:: Despite advancements in cancer care, persistent gaps remain in the delivery of high-value end-of-life cancer care. The aim of this study was to examine views of health care payer organization stakeholders on approaches to the redesign of end-of-life cancer care delivery strategies to improve care.
Methods:: We conducted semistructured interviews with 34 key stakeholders (eg, chief medical officers, medical directors) in 12 health plans and 22 medical group organizations across the United States. Read More
J Oncol Pract 2018 Nov 15:JOP1800307. Epub 2018 Nov 15.
University of Virginia Health System, Charlottesville, VA; Atlanta Cancer Care, Atlanta, GA; and Medical University of South Carolina, Charleston, SC.
Purpose:: Twenty percent of patients with acute myeloid leukemia (AML) undergoing induction or reinduction chemotherapy at the University of Virginia Health System from May 2011 to August 2014 had a proven or probable invasive fungal infection (IFI). The purpose of our initiative was to reduce the percentage of proven or probable IFIs in patients with AML undergoing induction or reinduction chemotherapy at the University of Virginia Health System to 10% or less by June 2017, in concordance with national averages.
Methods:: A multidisciplinary team was formed to lead the comprehensive quality improvement (QI) initiative. Read More
J Oncol Pract 2018 Nov 15:JOP1800551. Epub 2018 Nov 15.
Perlmutter Cancer Center at NYU Langone Health, New York, NY.
J Oncol Pract 2018 Nov;14(11):e699-e710
Precision Health Economics; University of Southern California, Los Angeles, CA; and Novartis Pharmaceuticals Corporation, Emmaus, PA.
Purpose:: Performance-based payments to oncology providers participating in the Centers for Medicare & Medicaid Services (CMS) Oncology Care Model (OCM) are based, in part, on overall spending in 6-month episodes of care, including spending unrelated to oncology care. The amount of spending likely to occur outside of oncologists' purview is unknown.
Methods:: Following the OCM definition of an episode, we used SEER-Medicare data from 2006 to 2013 to identify episodes of cancer care for the following diagnoses: breast cancer (BC), non-small-cell lung cancer, renal cell carcinoma, multiple myeloma (MM), and chronic myeloid leukemia. Read More
J Oncol Pract 2018 Nov;14(11):649-657
University of Chicago, Chicago, IL.
The treatment of acute promyelocytic leukemia (APL) has evolved rapidly in the past two decades after the introduction of highly active drugs, including tretinoin (all- trans-retinoic acid) and arsenic trioxide. It is now possible to treat this disease without the use of traditional cytotoxic chemotherapy. Today's clinical guidelines include multiple regimens, some of which continue to use cytotoxic chemotherapy. Read More
J Oncol Pract 2018 Nov;14(11):663-664
The University of Texas MD Anderson Cancer Center, Houston, TX.
J Oncol Pract 2018 Nov;14(11):676-678
Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL.
J Oncol Pract 2018 Nov;14(11):665-671
George Washington University Cancer Center, Washington, DC.
Burkitt's lymphoma is a rarely encountered, aggressive B-cell lymphoma that is highly curable in children and young adults. In middle-aged and older adults, however, administering curative therapy may be challenging because standard Burkitt's lymphoma platforms are associated with high treatment-related toxicity in these age groups. Because of its high curability, the testing of alternative, less toxic approaches in Burkitt's lymphoma has been challenging. Read More
J Oncol Pract 2018 Nov;14(11):679-680
University of Nebraska Medical Center, Omaha, NE.
J Oncol Pract 2018 Nov;14(11):635-638
Indiana University School of Medicine, Indianapolis, IN; University of Wisconsin School of Medicine, Madison, WI; and Oregon Health and Science University, Portland, OR.
J Oncol Pract 2018 Nov;14(11):639-641
Vanderbilt University; and Vanderbilt University Medical Center, Nashville, TN.
J Oncol Pract 2018 Nov;14(11):e674-e682
University of Illinois at Chicago, Chicago, IL.
Purpose:: We hypothesized that a multidisciplinary collaborative physician-pharmacist multiple myeloma clinic would improve adherence to treatment and supportive care guidelines as well as reduce delays in receiving oral antimyeloma therapy.
Methods:: From March 2014 to February 2015, an oncology pharmacist provided consultation for all patients in a specialist myeloma clinic. This included reviewing medications, ensuring physician adherence to supportive care guidelines, managing treatment-related adverse effects, and navigating issues involving access to oral specialty medications (collaborative clinic). Read More
J Oncol Pract 2018 Nov 8:JOP1800229. Epub 2018 Nov 8.
Columbia University College of Physicians and Surgeons; and Columbia University Mailman School of Public Health, New York, NY.
Purpose:: Follow-up guidelines vary widely among national organizations for patients with early-stage breast cancer treated with curative intent. We sought to evaluate the patterns and predictors of provider follow-up care within the first 5 years after diagnosis.
Methods:: Using the SEER-Medicare linked data set, we evaluated patients who were diagnosed with stage I and II breast cancer who underwent breast-conserving surgery from 2002 to 2007 with follow-up until 2012. Read More
J Oncol Pract 2018 Nov 8:JOP1800234. Epub 2018 Nov 8.
University of Pittsburgh School of Medicine; Via Oncology, Pittsburgh, PA; and Icahn School of Medicine at Mount Sinai, New York, NY.
Purpose:: The proportion of patients with advanced cancer who receive outpatient specialty palliative care (OSPC) is as low as 2.0%. Improved understanding of the system-level factors influencing use of OSPC could inform adaptations to the delivery of palliative care to maximize access. Read More
JOP 2018 Sep;19(5):273-275
Tufts University School of Medicine, Boston, MA, 02111.
Introduction: Drug-induced exanthems are commonly associated with NSAIDs, antibiotics, and anti-epileptics. Pancrelipase is frequently used for conditions resulting in pancreatic exocrine insufficiency. Published case reports of pancrelipase hypersensitivity focus on the respiratory manifestations. Read More
JOP 2018 Sep 18;19(5). Epub 2018 Sep 18.
The Department of Medicine, Tufts Medical Center, Boston MA, USA.
Background: Gastroenteropancreatic neuroendocrine tumors are neoplasms commonly found within the gastrointestinal tract that originate from endocrine cells. These are slow progressive tumors and often metastasize to other elements of the gastrointestinal tract including the liver. Consequently, these tumors release hormones including serotonin and/or histamine that are responsible for the symptoms including intermittent flushing and diarrhea. Read More
J Oncol Pract 2018 Nov 1:JOP1800367. Epub 2018 Nov 1.
Atrium Health (Formerly Carolinas Healthcare System), Charlotte, NC; and University of Florida College of Medicine, Gainesville, FL.
Social media (SM) platforms such as Facebook, Instagram, Twitter, and online cancer support groups are an emerging source of social support. However, oncology care professionals may be unfamiliar with how patients use SM related to their cancer diagnosis. SM can be potentially beneficial by providing an avenue for patient engagement and empowerment, increasing psychosocial and informational support, strengthening patient-physician relationships, and relaying opportunities for clinical and research study participation. Read More
J Oncol Pract 2018 Oct 31:JOP1700040. Epub 2018 Oct 31.
Florida Cancer Specialists and Research Institute, Gainesville; Xcenda, Palm Harbor, FL; and IntrinsiQ, Fresno, AZ.
Purpose:: Access to high-quality cancer care remains a challenge for many patients. One such barrier is the increasing cost of treatment. With recent shifts in cancer care delivery from community-based to hospital-based clinics, we examined whether this shift could result in increased costs for patients with three common tumor types. Read More
J Oncol Pract 2018 Oct 24:JOP1800222. Epub 2018 Oct 24.
Washington University School of Medicine; Siteman Cancer Center at Barnes-Jewish Hospital, St Louis, MO; and Helen F Graham Cancer Center and Research Institute, Christiana Care Health System, Newark, DE.
J Oncol Pract 2018 Oct 24:JOP1800120. Epub 2018 Oct 24.
Atrium Health, Charlotte; University of North Carolina, Chapel Hill, NC; Vanderbilt University Medical Center, Nashville, TN; The University of Alabama at Birmingham, Birmingham, AL.
Purpose:: Because of the escalating cost of cancer care coupled with high insurance deductibles, premiums, and uninsured populations, patients with cancer are affected by treatment-related financial harm, known as financial toxicity. The purpose of this study was to describe individuals reporting financial toxicity and to identify rates of and reasons for affordability-related treatment noncompliance.
Methods:: From May 2010 to November 2015, adult patients (age ≥ 18 years) with cancer were identified from a Health Registry/Cancer Survivorship Cohort. Read More
Colloids Surf B Biointerfaces 2018 Oct 9;173:539-548. Epub 2018 Oct 9.
School of Mechanical Engineering, Chonnam National University, 77 Yongbong-ro, Buk-gu, Gwangju, 61186, Republic of Korea; Medical Microrobot Center and Robot Research Initiative, Chonnam National University, 43-26, Cheomdangwagi-ro 208-beon-gil, Buk-gu, Gwangju, 61011, Republic of Korea. Electronic address:
An effective nanoparticle-based drug delivery platform holds great promise for non-invasive cancer therapy. This study explores the breast tumor regression in vivo by synergistic photothermal-chemotherapy based on liposomal nanocomplex (folic acid-gold nanorods-anticancer drug-liposome). The proposed liposomal nanocomplex can enhance the tumor targeting by functionalizing folic acid (FA) molecules on the surface of liposome that encapsulates both gold nanorods (AuNRs) and the doxorubicin (DOX) to combine the photothermal therapy and the chemotherapy, respectively. Read More
J Oncol Pract 2018 Oct 18:JOP1800261. Epub 2018 Oct 18.
Stanford Cancer Institute; Stanford University, Stanford, CA.
Online communities are virtual spaces dedicated to hosting conversations between individuals with a common interest. Information can be shared and obtained incrementally, as users can periodically post both questions and responses to other users' questions. Although online communities have been used frequently by patients for a myriad of health issues, much remains to be learned about these resources. Read More
J Oncol Pract 2018 Oct 15:JOP1800157. Epub 2018 Oct 15.
HealthCore, Wilmington, DE; Anthem National Accounts, New York, NY; Anthem, Bloomfield Hills, MI; Oncology Solutions, Woodland Hills, CA; and AIM Specialty Health, Chicago, IL.
Purpose:: Pathway regimens are value-driven, evidence-based therapies that aim at high-quality, affordable cancer care. There are few real-world data to support the value of such regimens, especially for patients with breast cancer.
Materials And Methods:: Using nationally representative claims data from Anthem, together with clinical data from its Cancer Care Quality Program, we identified patients with breast cancer for whom chemotherapy was initiated between January 2015 and October 2016. Read More
J Oncol Pract 2018 Oct;14(10):603-605
Massachusetts General Hospital and Harvard Medical School, Boston, MA.
J Oncol Pract 2018 Oct;14(10):594-602
The University of Hong Kong, Hong Kong, Special Administrative Region; and The University of Hong Kong-Shenzhen Hospital, Shenzhen, People's Republic of China.
Nasopharyngeal carcinoma of the undifferentiated histologic subtype is endemic and prevalent in southeast Asia. The dramatic improvement of treatment outcomes and overall prognosis during the past few decades has been attributed to advances in disease screening and diagnosis, diagnostic imaging, radiotherapy techniques, use of combination systemic therapy, and dedicated clinical and biomarker surveillance. The current practice of treating patients with advanced locoregional disease using cisplatin concurrent with conventional fractionated radiotherapy, followed by adjuvant cisplatin and fluorouracil, was established in 1998 when the landmark Intergroup-0099 Study demonstrated a survival benefit with the addition of systemic therapy. Read More
J Oncol Pract 2018 Oct;14(10):588-590
Levine Cancer Institute/Atrium Health, Charlotte, NC.
J Oncol Pract 2018 Oct;14(10):591-593
Duke University Medical Center; and Duke Cancer Institute, Durham, NC.
J Oncol Pract 2018 Oct;14(10):607-608
Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE.
J Oncol Pract 2018 Oct;14(10):580-587
Memorial Sloan Kettering Cancer Center; Weill Cornell Medical College; and New York-Presbyterian Hospital, New York, NY.
Androgen-deprivation therapy (ADT) entails lowering serum testosterone levels to castrate levels and forms a cornerstone of the management of hormone-sensitive advanced prostate cancer; however, the benefit of ADT is partially offset by its detrimental metabolic and cardiovascular adverse effects. ADT decreases insulin sensitivity while promoting dyslipidemia and sarcopenic obesity, which leads to an increased risk of cardiovascular morbidity and potentially mortality. The risk seems to be highest in elderly patients who have had recent cardiovascular events before starting ADT. Read More