517 results match your criteria JONA: The Journal of Nursing Administration [Journal]


Brown adipose tissue thermogenesis in polycystic ovary syndrome.

Clin Endocrinol (Oxf) 2018 Dec 12. Epub 2018 Dec 12.

Department of Physiology, Monash University, Melbourne, Victoria, Australia.

Objective: Polycystic ovary syndrome (PCOS) is associated with increased obesity with a greater propensity to weight gain and a lack of sustainable lifestyle interventions. Altered brown adipose tissue (BAT) thermogenesis is a potential contributor to obesity in PCOS. BAT activity and modulation has not been studied in PCOS. Read More

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December 2018
1 Read

Effect of Central Sympathoinhibition With Moxonidine on Sympathetic Nervous Activity in Polycystic Ovary Syndrome-A Randomized Controlled Trial.

Front Physiol 2018 25;9:1486. Epub 2018 Oct 25.

Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.

Sympathetic nervous system (SNS) activity is increased in polycystic ovary syndrome (PCOS). Moxonidine is a centrally acting sympatholytic drug with known beneficial effects on hypertension, insulin sensitivity, dyslipidemia and inflammation. In this double-blind placebo controlled randomized clinical trial we examined the effect of moxonidine on modulating sympathetic activity and downstream metabolic abnormalities in 48 pre-menopausal women with PCOS (Rotterdam diagnostic criteria), recruited from the community (January 2013-August 2015). Read More

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October 2018
3 Reads

A Bacterial Growth Law out of Steady State.

Cell Rep 2018 Jun;23(10):2891-2900

Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 7610001, Israel. Electronic address:

Bacterial growth follows simple laws in constant conditions. However, bacteria in nature often face fluctuating environments. We therefore ask whether there are growth laws that apply to changing environments. Read More

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Apolipoprotein M Protects Lipopolysaccharide-Treated Mice from Death and Organ Injury.

Thromb Haemost 2018 Jun 18;118(6):1021-1035. Epub 2018 Apr 18.

Department of Clinical Laboratory Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

Objective:  High-density lipoprotein (HDL) has been epidemiologically shown to be associated with the outcome of sepsis. One potential mechanism is that HDL possesses pleiotropic effects, such as anti-apoptosis, some of which can be ascribed to sphingosine 1-phosphate (S1P) carried on HDL via apolipoprotein M (apoM). Therefore, the aim of this study was to elucidate the roles of apoM/S1P in the consequent lethal conditions of sepsis, such as multiple organ failure caused by severe inflammation and/or disseminated intravascular coagulation. Read More

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June 2018
7 Reads

Laser induced calcium oscillations in fluorescent calcium imaging.

Gen Physiol Biophys 2018 May 28;37(3):253-261. Epub 2018 Mar 28.

Department of Physiology, University of Debrecen, Faculty of Medicine, 98. Nagyerdei krt., Debrecen 4012, Hungary.

Phototoxicity is the most common problem investigators may encounter when performing live cell imaging. It develops due to excess laser exposure of cells loaded with fluorophores and can lead to often overlooked but significant artifacts, such as massive increase of intracellular Ca2+ concentration, which would make data interpretation problematic. Because information about laser- and dye-related changes in cytoplasmic calcium concentration is very limited, we aimed to describe this phenomenon to help investigators using laser scanning confocal microscopy in a non-invasive way. Read More

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Eculizumab treatment for ischemic enteritis accompanied with paroxysmal nocturnal hemoglobinuria: a case report and literature review.

Ann Hematol 2018 Aug 13;97(8):1513-1515. Epub 2018 Mar 13.

Department of Hematology and Oncology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.

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August 2018
2 Reads

Blood Glutamate Scavenger as a Novel Neuroprotective Treatment in Spinal Cord Injury.

J Neurotrauma 2018 Nov 15;35(21):2581-2590. Epub 2018 May 15.

1 Steyer School of Health Professions, Sackler School of Medicine, Tel-Aviv University , Tel Aviv, Israel .

Neurotrauma causes immediate elevation of extracellular glutamate (Glu) levels, which creates excitotoxicity and facilitates inflammation, glial scar formation, and consequently neuronal death. Finding factors that reduce the inflammatory response and glial scar formation, and increase neuronal survival and neurite outgrowth, are of major importance for improving the outcome after spinal cord injury (SCI). In the present study, we evaluated a new treatment aiming to remove central nervous system (CNS) Glu into the systemic blood circulation by intravenous (IV) administration of blood Glu scavengers (BGS) such as the enzyme recombinant glutamate-oxaloacetate transaminase 1 (rGOT1) and its co-substrate. Read More

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November 2018
7 Reads

[Healthcare expenditures and the role of demografic change : An analysis of statutory health insurance data].

Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 2018 Apr;61(4):432-441

AOK Niedersachsen, Hildesheimer Str. 273, 30519, Hannover, Deutschland.

The development of healthcare expenditures and the impact of demographic change are the subject of a controversial debate. Yearly healthcare expenditures have more than doubled between 1992 and 2015 and are often justified by the aging demographic. The majority of expenses are paid by the statutory health insurance (SHI). Read More

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April 2018
1 Read

High-molecular-weight adiponectin is inversely associated with sympathetic activity in polycystic ovary syndrome.

Fertil Steril 2018 03 7;109(3):532-539. Epub 2018 Feb 7.

Monash Centre for Health Research and Implementation, Monash University, Clayton, Victoria, Australia; Diabetes and Vascular Medicine Unit, Monash Health, Melbourne, Victoria, Australia. Electronic address:

Objective: To examine the role of high-molecular-weight (HMW) adiponectin and its relationship to sympathetic activity in women with polycystic ovary syndrome (PCOS).

Design: Cross sectional study using biobanked samples.

Setting: Not applicable. Read More

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March 2018
2 Reads

From hadrons to quarks in neutron stars: a review.

Rep Prog Phys 2018 05 9;81(5):056902. Epub 2018 Feb 9.

Department of Physics, University of Illinois at Urbana-Champaign, 1110 W. Green Street, Urbana, IL 61801, United States of America. iTHES Research Group, RIKEN, Wako, Saitama 351-0198, Japan. The Niels Bohr International Academy, The Niels Bohr Institute, University of Copenhagen, Blegdamsvej 17, DK-2100 Copenhagen Ø, Denmark.

In recent years our understanding of neutron stars has advanced remarkably, thanks to research converging from many directions. The importance of understanding neutron star behavior and structure has been underlined by the recent direct detection of gravitational radiation from merging neutron stars. The clean identification of several heavy neutron stars, of order two solar masses, challenges our current understanding of how dense matter can be sufficiently stiff to support such a mass against gravitational collapse. Read More

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May 2018
1 Read

Velocity-pressure loops for continuous assessment of ventricular afterload: influence of pressure measurement site.

J Clin Monit Comput 2018 Oct 29;32(5):833-840. Epub 2017 Nov 29.

Department of Anesthesiology and Critical Care, St-Louis-Lariboisière-Fernand Widal University Hospitals, Assistance Publique - Hôpitaux de Paris, Paris, France.

VPloop, the graphical representation of pressure versus velocity, and its characteristic angles, GALA and β, can be used to monitor cardiac afterload during anesthesia. Ideally VPloop should be measured from pressure and velocity obtained at the same arterial location but standard of care usually provide either radial or femoral pressure waveforms. The purpose of this study was to look at the influence of arterial sites and the use of a transfer function (TF) on VPloop and its related angles. Read More

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October 2018
8 Reads

Clinical features of hematological disorders with increased large granular lymphocytes (LGLs): a retrospective study.

Ann Hematol 2017 Dec 2;96(12):2113-2115. Epub 2017 Nov 2.

Department of Hematology and Oncology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.

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December 2017
8 Reads

Families Affected by Huntington's Disease Report Difficulties in Communication, Emotional Involvement, and Problem Solving.

J Huntingtons Dis 2017 ;6(3):169-177

School of Psychological Sciences, Monash Institute of Cognitive and Clinical Neurosciences, Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton Campus, VIC, Australia.

Background: Family functioning in Huntington's disease (HD) is known from previous studies to be adversely affected. However, which aspects of family functioning are disrupted is unknown, limiting the empirical basis around which to create supportive interventions.

Objective: The aim of the current study was to assess family functioning in HD families. Read More

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May 2018
18 Reads

[Treatment of relapsed Hodgkin lymphoma after autologous stem cell transplantation].

Orv Hetil 2017 Aug;158(34):1338-1345

Belgyógyászati Intézet, Hematológiai Tanszék, Debreceni Egyetem, Általános Orvostudományi Kar Debrecen, Nagyerdei krt. 98., 4032.

Approximately 10-30% of Hodgkin lymphoma patients relapses or experience refractory disease after first line treatment. Nowadays, autologous stem cell transplantation can successfully salvage half of these patients, median overall survival is only 2-2.5 years. Read More

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August 2017
1 Read

Lanthanides Report Calcium Sensor in the Vestibule of Ryanodine Receptor.

Biophys J 2017 May;112(10):2127-2137

Department of Physiology, Faculty of Medicine, Department of Laboratory Medicine, Faculty of Medicine, University of Debrecen, Debrecen, Hungary. Electronic address:

Ca regulates ryanodine receptor's (RyR) activity through an activating and an inhibiting Ca-binding site located on the cytoplasmic side of the RyR channel. Their altered sensitivity plays an important role in the pathology of malignant hyperthermia and heart failure. We used lanthanide ions (Ln) as probes to investigate the Ca sensors of RyR, because they specifically bind to Ca-binding proteins and they are impermeable to the channel. Read More

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May 2017
20 Reads

Heterosis as a consequence of regulatory incompatibility.

BMC Biol 2017 05 11;15(1):38. Epub 2017 May 11.

Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, 7610001, Israel.

Background: The merging of genomes in inter-specific hybrids can result in novel phenotypes, including increased growth rate and biomass yield, a phenomenon known as heterosis. Heterosis is typically viewed as the opposite of hybrid incompatibility. In this view, the superior performance of the hybrid is attributed to heterozygote combinations that compensate for deleterious mutations accumulating in each individual genome, or lead to new, over-dominating interactions with improved performance. Read More

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May 2017
31 Reads

Involvement of Band3 in the efflux of sphingosine 1-phosphate from erythrocytes.

PLoS One 2017 11;12(5):e0177543. Epub 2017 May 11.

Department of Clinical Laboratory Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

Sphingosine 1-phosphate (S1P) is a bioactive lipid mediator that is thought to be involved in various diseases. Although the main source of S1P in the plasma is erythrocytes, how S1P is exported from erythrocytes has not been elucidated. When we differentiated K562 cells into erythroblast-like cells with sodium butyrate, we observed that the efflux of S1P was increased without increased expression of previously proposed S1P transporters, while the expression levels of Band3 were increased. Read More

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September 2017
19 Reads

Proper time regularization and the QCD chiral phase transition.

Sci Rep 2017 04 12;7:45937. Epub 2017 Apr 12.

Department of Physics, Nanjing University, Nanjing, 210093, China.

We study the QCD chiral phase transition at finite temperature and finite quark chemical potential within the two flavor Nambu-Jona-Lasinio (NJL) model, where a generalization of the proper-time regularization scheme is motivated and implemented. We find that in the chiral limit the whole transition line in the phase diagram is of second order, whereas for finite quark masses a crossover is observed. Moreover, if we take into account the influence of quark condensate to the coupling strength (which also provides a possible way of how the effective coupling varies with temperature and quark chemical potential), it is found that a CEP may appear. Read More

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April 2017
9 Reads

Hand hygiene in intensive care units: a matter of time?

J Hosp Infect 2017 Apr 28;95(4):338-343. Epub 2017 Jan 28.

Hannover Medical School, Institute for Epidemiology, Social Medicine and Health Systems Research, Hannover, Germany.

Background: Healthcare-associated infections are a frequent threat to patient safety and cause significant disease burden. The most important single preventive measure is hand hygiene (HH). Barriers to adherence with HH recommendations include structural aspects, knowledge gaps, and organizational issues, especially a lack of time in daily routine. Read More

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April 2017
5 Reads

[Rare delusional ideation of zoanthropy].

Nervenarzt 2018 Jan;89(1):92-93

Klinik für Psychiatrie, Psychotherapie und psychosomatische Medizin, kbo Isar Amper Klinikum, Klinikum München Ost, Vockestr. 72, 85540, Haar, Deutschland.

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January 2018

Cost-Effectiveness of Treating Hepatitis C with Sofosbuvir/Ledipasvir in Germany.

PLoS One 2017 3;12(1):e0169401. Epub 2017 Jan 3.

Institute for Epidemiology, Social Medicine and Health Systems Research; Hannover Medical School; Hannover; Germany.

Background: Infections with the hepatitis C virus (HCV) are a global public health problem. Long-term consequences are the development of liver cirrhosis and hepatocellular carcinoma. Newly introduced direct acting antivirals, especially interferon-free regimens, have improved rates of sustained viral response above 90% in most patient groups and allow treating patients who were ineligible for treatment in the past. Read More

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August 2017
5 Reads

Vitamin D in newborns. A randomised controlled trial comparing daily and single oral bolus vitamin D in infants.

J Paediatr Child Health 2017 Feb 27;53(2):163-169. Epub 2016 Sep 27.

Women's and Children's Division, Sunshine Hospital, Melbourne, Victoria, Australia.

Aim: There are no published data to demonstrate the efficacy of bolus dose vitamin D in newborn infants. The study sought to evaluate this alternative approach of supplementation.

Methods: This single centre, open randomised controlled trial was conducted from August 2013 to May 2014. Read More

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February 2017
14 Reads

Following Metabolism in Living Microorganisms by Hyperpolarized (1)H NMR.

J Am Chem Soc 2016 09 6;138(37):12278-86. Epub 2016 Sep 6.

Klinik und Poliklinik für Nuklearmedizin, Technische Universität München , München 81675, Germany.

Dissolution dynamic nuclear polarization (dDNP) is used to enhance the sensitivity of nuclear magnetic resonance (NMR), enabling monitoring of metabolism and specific enzymatic reactions in vivo. dDNP involves rapid sample dissolution and transfer to a spectrometer/scanner for subsequent signal detection. So far, most biologically oriented dDNP studies have relied on hyperpolarizing long-lived nuclear spin species such as (13)C in small molecules. Read More

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September 2016
10 Reads
5 Citations
12.113 Impact Factor

A common misapplication of statistical inference: Nuisance control with null-hypothesis significance tests.

Brain Lang 2016 11 17;162:42-45. Epub 2016 Aug 17.

University of South Australia, Adelaide, Australia.

Experimental research on behavior and cognition frequently rests on stimulus or subject selection where not all characteristics can be fully controlled, even when attempting strict matching. For example, when contrasting patients to controls, variables such as intelligence or socioeconomic status are often correlated with patient status. Similarly, when presenting word stimuli, variables such as word frequency are often correlated with primary variables of interest. Read More

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November 2016

Liquid exfoliation of alkyl-ether functionalised layered metal-organic frameworks to nanosheets.

Chem Commun (Camb) 2016 Aug;52(69):10474-7

University of Cambridge, Materials Science and Metallurgy, 27 Charles Babbage Road, Cambridge, CB3 0FS, UK.

We report the synthesis of a 2D-layered metal-organic framework incorporating weakly interacting chains designed to aid exfoliation of the layers into nanosheets. Dispersion of the nanosheets exposes labile metal-sites which are shown to exchange solvent molecules allowing the nanosheets to act as sensors in suspension. Read More

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August 2016
1 Read

Rapidly Progressing Refractory Hodgkin Lymphoma: A Case Report and a Possible Explanation.

Case Rep Med 2016 26;2016:7698624. Epub 2016 Jun 26.

Department of Hematology, Faculty of Medicine, University of Debrecen, Debrecen 4032, Hungary.

Introduction. Hodgkin lymphoma is a highly curable lymphoid malignancy; however treatment of a significant number of patients remains challenging. Case Report. Read More

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July 2016
5 Reads

Sugar Synthesis from CO2 in Escherichia coli.

Cell 2016 Jun 23;166(1):115-25. Epub 2016 Jun 23.

Department of Plant and Environmental Sciences, Weizmann Institute of Science, Rehovot 7610001, Israel. Electronic address:

Can a heterotrophic organism be evolved to synthesize biomass from CO2 directly? So far, non-native carbon fixation in which biomass precursors are synthesized solely from CO2 has remained an elusive grand challenge. Here, we demonstrate how a combination of rational metabolic rewiring, recombinant expression, and laboratory evolution has led to the biosynthesis of sugars and other major biomass constituents by a fully functional Calvin-Benson-Bassham (CBB) cycle in E. coli. Read More

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June 2016
9 Reads

Properties of mesons in a strong magnetic field.

Eur Phys J C Part Fields 2016;76:307. Epub 2016 Jun 2.

Department of Physics, State Key Laboratory of Nuclear Physics and Technology, Peking University, Beijing, 100871 China ; Collaborative Innovation Center of Quantum Matter, Beijing, 100871 China ; Center for High Energy Physics, Peking University, Beijing, 100871 China.

By extending the [Formula: see text]-derivable approach in the Nambu-Jona-Lasinio model to a finite magnetic field we calculate the properties of pion, [Formula: see text], and [Formula: see text] mesons in a magnetic field at finite temperature not only in the quark-antiquark bound state scheme but also in the pion-pion scattering resonant state scenario. Our calculation as a result makes manifest that the masses of [Formula: see text] and [Formula: see text] meson can be nearly degenerate at the pseudo-critical temperature which increases with increasing magnetic field strength, and the [Formula: see text] mass ascends suddenly at almost the same critical temperature. Meanwhile the [Formula: see text] mesons' masses decrease with the temperature but increase with the magnetic field strength. Read More

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June 2016
2 Reads

Noise, uncertainty, and interest: Predictive coding and cognitive penetration.

Conscious Cogn 2017 01 18;47:86-98. Epub 2016 Jun 18.

Department of Philosophy, University of Utah, USA. Electronic address:

This paper concerns how extant theorists of predictive coding conceptualize and explain possible instances of cognitive penetration. Section 1 offers brief clarification of the predictive coding framework and of cognitive penetration. Section 2 develops more precise ways that the predictive coding framework can explain genuine top-down causal effects on perceptual experience. Read More

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January 2017
1 Read

Effect of Bleomycin Hydrolase Gene Polymorphism on Late Pulmonary Complications of Treatment for Hodgkin Lymphoma.

PLoS One 2016 21;11(6):e0157651. Epub 2016 Jun 21.

Department of Hematology, University of Debrecen, Faculty of Medicine, Debrecen, Hungary.

Background: Bleomycin hydrolase (BLMH), an enzyme that inactivates bleomycin, may be a potential candidate that could influence pulmonary function in ABVD (doxorubicin, bleomycin, vinblastin, dacarbasine)-treated Hodgkin lymphoma (HL) patients.

Patients And Methods: We hypothesized that the BLMH gene SNP A1450G (rs1050565) influences BLMH activity and late pulmonary toxicity. St. Read More

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July 2017
20 Reads

Using Synthetic Mouse Spike-In Transcripts to Evaluate RNA-Seq Analysis Tools.

PLoS One 2016 21;11(4):e0153782. Epub 2016 Apr 21.

Biological Services Department, Weizmann Institute of Science, Rehovot, 76100, Israel.

One of the key applications of next-generation sequencing (NGS) technologies is RNA-Seq for transcriptome genome-wide analysis. Although multiple studies have evaluated and benchmarked RNA-Seq tools dedicated to gene level analysis, few studies have assessed their effectiveness on the transcript-isoform level. Alternative splicing is a naturally occurring phenomenon in eukaryotes, significantly increasing the biodiversity of proteins that can be encoded by the genome. Read More

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September 2016
11 Reads
2 Citations
3.234 Impact Factor

[Pulmonary alterations in Hodgkin lymphoma].

Orv Hetil 2016 Jan;157(5):163-73

Belgyógyászati Intézet, Hematológiai Tanszék, Debreceni Egyetem, Általános Orvostudományi Kar Debrecen, Nagyerdei krt. 98., 4032.

Most of Hodgkin lymphoma patients survive due to combined chemo/radiotherapy. Improved survival brings long-term side effects to the front, which may determine the patients' subsequent quality of life and expected lifetime. This manuscript aims to analyze lung manifestations of Hodgkin lymphoma and treatment related pulmonary complications, demonstrated with own cases. Read More

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January 2016
1 Read

[Idiopathic dysplasia of undetermined/uncertain significance (IDUS) initially presenting erythroblastosis and hyperferritinemia].

Rinsho Ketsueki 2015 Dec;56(12):2462-6

Department of Clinical Laboratory, The University of Tokyo Hospital.

A 64-year-old man was referred to our hospital because of mild anemia, erythroblasts in peripheral blood, and hyperferritinemia. In our hospital, no evidence of cytopenia was found. The peripheral blood smear showed pseudo-Pelger-Huët anomaly and giant platelets. Read More

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December 2015
2 Reads

The Cost of Protein Production.

Cell Rep 2016 Jan 24;14(1):22-31. Epub 2015 Dec 24.

Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel. Electronic address:

The economy of protein production is central to cell physiology, being intimately linked with cell division rate and cell size. Attempts to model cellular physiology are limited by the scarcity of experimental data defining the molecular processes limiting protein expression. Here, we distinguish the relative contribution of gene transcription and protein translation to the slower proliferation of budding yeast producing excess levels of unneeded proteins. Read More

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January 2016
3 Reads

[Novel treatment options in relapsed and refracter Hodgkin lymphomas].

Orv Hetil 2015 Nov;156(45):1824-33

Belgyógyászati Intézet, Hematológiai Tanszék, Debreceni Egyetem, Általános Orvostudományi Kar Debrecen.

Introduction: Hodgkin lymphoma is a curable lymphoma with an 80-90% long-term survival, however, 30% of the patients develop relapse. Only half of relapsed patients can be cured with autologous stem cell transplantation.

Aim: The aim of the authors was to analyze survival rates and incidence of relapses among Hodgkin lymphoma patients who were treated between January 1, 1980 and December 31, 2014. Read More

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November 2015

Combined prognostic value of absolute lymphocyte/monocyte ratio in peripheral blood and interim PET/CT results in Hodgkin lymphoma.

Int J Hematol 2016 Jan;103(1):63-9

Decreased absolute lymphocyte/monocyte ratio (LMR) in peripheral blood has been reported as an unfavorable prognostic marker in Hodgkin lymphoma. We aimed to investigate whether combining LMR and interim PET/CT scan result (PET2) confers stronger prognostic value than PET2 alone. 121 HL patients were investigated. Read More

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January 2016

Noise in gene expression is coupled to growth rate.

Genome Res 2015 Dec 9;25(12):1893-902. Epub 2015 Sep 9.

Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, Rehovot 76100, Israel; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel;

Genetically identical cells exposed to the same environment display variability in gene expression (noise), with important consequences for the fidelity of cellular regulation and biological function. Although population average gene expression is tightly coupled to growth rate, the effects of changes in environmental conditions on expression variability are not known. Here, we measure the single-cell expression distributions of approximately 900 Saccharomyces cerevisiae promoters across four environmental conditions using flow cytometry, and find that gene expression noise is tightly coupled to the environment and is generally higher at lower growth rates. Read More

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December 2015
12 Reads

Growth dynamics of gut microbiota in health and disease inferred from single metagenomic samples.

Science 2015 Sep 30;349(6252):1101-1106. Epub 2015 Jul 30.

Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, Rehovot, Israel.

Metagenomic sequencing increased our understanding of the role of the microbiome in health and disease, yet it only provides a snapshot of a highly dynamic ecosystem. Here, we show that the pattern of metagenomic sequencing read coverage for different microbial genomes contains a single trough and a single peak, the latter coinciding with the bacterial origin of replication. Furthermore, the ratio of sequencing coverage between the peak and trough provides a quantitative measure of a species' growth rate. Read More

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September 2015
82 Reads

Combined Treatment of an Amyotrophic Lateral Sclerosis Rat Model with Recombinant GOT1 and Oxaloacetic Acid: A Novel Neuroprotective Treatment.

Neurodegener Dis 2015 23;15(4):233-42. Epub 2015 Jun 23.

Department of Neurobiology, Weizmann Institute of Science, Rehovot, Israel.

Background/aim: The sporadic form of the disease affects the majority of amyotrophic lateral sclerosis (ALS) patients. The role of glutamate (Glu) excitotoxicity in ALS has been extensively documented and remains one of the prominent hypotheses of ALS pathogenesis. In light of this evidence, the availability of a method to remove excess Glu from brain and spinal cord extracellular fluids without the need to deliver drugs across the blood-brain barrier and with minimal or no adverse effects may provide a major therapeutic asset, which is the primary aim of this study. Read More

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April 2016
1 Read

Prognostic value of interim and restaging PET/CT in Hodgkin lymphoma. Results of the CHEAP (Chemotherapy Effectiveness Assessment by PET/CT) study - long term observation.

Neoplasma 2015;62(4):627-34

Very few studies have determined the prognostic value of interim and restaging PET/CT in patients with Hodgkin lymphoma using current standard of care therapy outside clinical trials. We analyzed the effect of the results of interim and restaging PET/CT on the survival (overall- and relapse-free) in patients who received standard first-line treatment based on the stage of disease and risk factors. We investigated the differences between the relapse and non-relapse groups based on the clinical pathological characteristics of patients who had positive interim PET/CT results. Read More

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January 2015

Bile acids activate ryanodine receptors in pancreatic acinar cells via a direct allosteric mechanism.

Cell Calcium 2015 Aug 17;58(2):160-70. Epub 2015 Apr 17.

Department of Physiology, University of Debrecen, Faculty of Medicine, 98. Nagyerdei krt. PO Box: 22, Debrecen 4012, Hungary; Research Center for Molecular Medicine, University of Debrecen, Faculty of Medicine, 98. Nagyerdei krt. PO Box: 72, Debrecen 4012, Hungary. Electronic address:

The earliest critical event of pancreatitis is a long lasting high amplitude rise of intracellular Ca(2+) concentration of the acinar cell, which can be triggered by high concentration of bile acids. Although, Ca(2+)-release through ryanodine receptors (RyR) is involved in the process, the significance and the exact mechanism of bile acid's action on RyR has not been fully elucidated yet. Therefore, we aimed to test with various techniques and aspects whether bile acids exert a direct effect on RyR and SERCA pump. Read More

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Sympathetic activation and endothelial dysfunction in polycystic ovary syndrome are not explained by either obesity or insulin resistance.

Clin Endocrinol (Oxf) 2015 Dec 13;83(6):812-9. Epub 2015 May 13.

Human Neurotransmitters Laboratory, Baker IDI Heart & Diabetes Institute, Melbourne, Vic., Australia.

Objective: Polycystic ovary syndrome (PCOS) is a common endocrine condition underpinned by insulin resistance and associated with increased risk of obesity, type 2 diabetes and adverse cardiovascular risk profile. Previous data suggest autonomic imbalance [elevated sympathetic nervous system (SNS) activity and decreased heart rate variability (HRV)] as well as endothelial dysfunction in PCOS. However, it is not clear whether these abnormalities are driven by obesity and metabolic disturbance or whether they are independently related to PCOS. Read More

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December 2015
3 Reads

Effects of fluvastatin and coenzyme Q10 on skeletal muscle in normo- and hypercholesterolaemic rats.

J Muscle Res Cell Motil 2015 Jun 29;36(3):263-74. Epub 2015 Apr 29.

Department of Physiology, Faculty of Medicine, University of Debrecen, Nagyerdei krt. 98, P.O. Box 22, Debrecen, 4012, Hungary.

Myalgia and muscle weakness may appreciably contribute to the poor adherence to statin therapy. Although the pathomechanism of statin-induced myopathy is not completely understood, changes in calcium homeostasis and reduced coenzyme Q10 levels are hypothesized to play important roles. In our experiments, fluvastatin and/or coenzyme Q10 was administered chronically to normocholesterolaemic or hypercholaestherolaemic rats, and the modifications of the calcium homeostasis and the strength of their muscles were investigated. Read More

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Conformational isomerism in solid state of AMG 853--structure studies using solid-state nuclear magnetic resonance and X-ray diffraction.

J Pharm Sci 2015 Jul 24;104(7):2161-8. Epub 2015 Apr 24.

Department of Physics and Astronomy, State University of New York, Stony Brook, New York, 11794-3800.

Investigation of an additional resonance peak in the (19) F solid-state nuclear magnetic resonance (NMR) spectrum of AMG 853, a dual antagonist of DP and CRTH2 previously in clinical development for asthma, has led to the identification of two conformational isomers coexisting in the crystal lattice in a continuous composition range between 89.7%:10.3% and 96. Read More

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July 2015
2 Reads

Poorer prognosis with ethylenediaminetetraacetic acid-dependent pseudothrombocytopenia: a single-center case-control study.

Medicine (Baltimore) 2015 Apr;94(15):e674

From the Department of Emergency and Critical Care Medicine, The University of Tokyo Hospital, Bunkyo-ku (NO-F, RI, KN, TW, SN, NY); Department of Emergency Medicine, JR General Hospital, Sibuya-ku, Tokyo (RI); Department of Emergency and Critical Care Medicine, Hitachi General Hospital, Hitachi-city, Ibaraki (KN); Department of Health Policy and Technology Assessment, National Institute of Public Health 2-3-6 Minami, Wako, Saitama, Japan (HS); London School of Hygiene and Tropical Medicine, Bloomsbury, London, United Kingdom (MI); and Department of Clinical Laboratory Medicine, The University of Tokyo Hospital, Bunkyo-ku, Tokyo, Japan (MJ, TH).

In ethylenediaminetetraacetic acid (EDTA)-dependent pseudothrombocytopenia (PTCP), automated platelet counts are lower than actual counts because of EDTA-induced aggregation. Factors contributing to the incidence of EDTA-PTCP are unknown, and no study has assessed the prognosis of EDTA-PTCP patients. This retrospective study assessed characteristics in EDTA-PTCP patients and matched controls to determine differences in prognosis. Read More

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April 2015
2 Reads

The P600 as a correlate of ventral attention network reorientation.

Cortex 2015 May 13;66:A3-A20. Epub 2015 Feb 13.

School of Psychology, Social Work and Social Policy, University of South Australia, Adelaide, Australia; Department of Germanic Linguistics, University of Marburg, Marburg, Germany.

When, during language processing, a reader or listener is confronted with a structurally deviant phrase, this typically elicits a late positive ERP deflection (P600). The P600 is often understood as a correlate of structural analysis. This assumption has informed a number of neurocognitive models of language. Read More

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May 2015
4 Reads

The criteria to suspect chronic myeloid leukemia using absolute basophil counts in peripheral blood.

Int J Hematol 2015 Jun 12;101(6):626-8. Epub 2015 Mar 12.

Department of Clinical Laboratory, The University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan,

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Asenapine in clinical practice: preliminary results from a naturalistic observational study.

Riv Psichiatr 2014 Nov-Dec;49(6):241-6

Objective: Asenapine, a second-generation antipsychotic, seems to be an effective and tolerable alternative to other treatments for patients with manic or mixed episodes. The objective of our naturalistic observational study was to identify asenapine responders and remitters and to compare responders vs. non-responders and remitters vs. Read More

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December 2016
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Brentuximab vedotin for treating Hodgkin's lymphoma: an analysis of pharmacology and clinical efficacy.

Expert Opin Drug Metab Toxicol 2015 Mar 2;11(3):451-9. Epub 2015 Feb 2.

University of Debrecen, Institution of Internal Medicine, Department of Hematology, Faculty of Medicine , Debrecen , Hungary.

Introduction: Hodgkin's lymphoma (HL) is a highly curable lymphoma with a 70 - 90% long-term survival; however, patients with relapsed or refractory disease may need additonal therapies and have significantly worse prognosis. Brentuximab vedotin (BV) is an anti-CD-30 antibody-drug conjugate, which was approved for treating classical HL patients following autologous stem cell transplantation or failure of at least two prior multi-agent chemotherapies within a year.

Areas Covered: Current clinical trials are investigating the role of BV in frontline, salvage and adjuvant setting of treatment. Read More

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