93,739 results match your criteria JAMA : the journal of the American Medical Association[Journal]


A Patient With an Elevated α-Fetoprotein Level and Liver Masses.

JAMA 2018 Dec 13. Epub 2018 Dec 13.

University of Chicago Medicine, Chicago, Illinois.

View Article
December 2018

The Essentials-Only Emergency Tracheotomy Pan: Keeping It Simple With Open Emergent Airways.

JAMA Otolaryngol Head Neck Surg 2018 Dec 13. Epub 2018 Dec 13.

Division of Otolaryngology-Head & Neck Surgery, The University of Wisconsin School of Public Health and Medicine, Madison.

View Article
December 2018

Inappropriate Grading of Adverse Events in Cancer Clinical Trials-Reply.

JAMA Oncol 2018 Dec 13. Epub 2018 Dec 13.

Department of Oncology, Lausanne University Hospital, Lausanne, Switzerland.

View Article
December 2018

Assessing the Prognostic Value of the Automated Bone Scan Index for Prostate Cancer.

JAMA Oncol 2018 Dec 13. Epub 2018 Dec 13.

Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, Massachusetts.

View Article
December 2018

Medicare's Approach to Paying for Services That Promote Coordinated Care.

JAMA 2018 Dec 13. Epub 2018 Dec 13.

Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia.

View Article
December 2018

Preliminary Steps to Address Glaucoma Medication Adherence: Beginning to Tackle the Elephant in the Room.

JAMA Ophthalmol 2018 Dec 13. Epub 2018 Dec 13.

Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania.

View Article
December 2018

Cytoreductive Nephrectomy in Metastatic Renal Cell Cancer: Not All That It's Cut Out to Be.

JAMA Oncol 2018 Dec 13. Epub 2018 Dec 13.

UC Davis Comprehensive Cancer Center, UC Davis School of Medicine, Sacramento, California.

View Article
December 2018

Assessing the Prognostic Value of the Automated Bone Scan Index for Prostate Cancer-Reply.

JAMA Oncol 2018 Dec 13. Epub 2018 Dec 13.

Memorial Sloan Kettering Cancer Center, New York, New York.

View Article
December 2018

Severe Facial-Disfiguring Xeroderma Pigmentosum With Rapidly Progressing Malignant Tumors.

JAMA Otolaryngol Head Neck Surg 2018 Dec 13. Epub 2018 Dec 13.

Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China.

View Article
December 2018

Is It Time to Rethink the Approach to Internal Nasal Valve Stenosis?

Authors:
William J Moss

JAMA Otolaryngol Head Neck Surg 2018 Dec 13. Epub 2018 Dec 13.

Division of Otolaryngology-Head & Neck Surgery, Department of Surgery, Commonwealth Health Center, Garapan, Saipan, Northern Mariana Islands.

View Article
December 2018

Association Between Conventional Bicycle Helmet Use and Facial Injuries After Bicycle Crashes.

JAMA Otolaryngol Head Neck Surg 2018 Dec 13. Epub 2018 Dec 13.

Department of Otolaryngology-Head and Neck Surgery, University of California, San Francisco.

Importance: Bicycling is an increasingly common activity in the United States that is often associated with fall injuries to the head and face. Although helmets lessen head injury, their role in reducing facial injuries is less clear; therefore, it is important to understand the protective capacity for the face in current helmet design.

Objective: To estimate the conventional bicycle helmet's association with the rate of facial injury after bicycle crashes. Read More

View Article
December 2018

Inappropriate Grading of Adverse Events in Cancer Clinical Trials.

JAMA Oncol 2018 Dec 13. Epub 2018 Dec 13.

Rizhao City Hospital of Traditional Chinese Medicine, Rizhao, China.

View Article
December 2018

Cyclin-Dependent Kinase Inhibitor-Associated Thromboembolism.

JAMA Oncol 2018 Dec 13. Epub 2018 Dec 13.

Division of Hematology and Medical Oncology, Knight Cancer Institute, Oregon Health and Science University, Portland.

View Article
December 2018

Parallels Between Low-Risk Prostate Cancer and Thyroid Cancer: A Review.

JAMA Oncol 2018 Dec 13. Epub 2018 Dec 13.

Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California.

Importance: Across many countries, a rapid escalation of the incidence of thyroid cancer has been observed, a surge that nonetheless underestimates the true extent of the disease. Most thyroid cancers now diagnosed comprise small, low-risk cancers that are incidentally found and are unlikely to cause harm. In many ways, prostate cancer similarly harbors a well-behaved subclinical reservoir, a long natural history, and superlative outcomes that have made active surveillance the de facto guideline recommendation for low-risk disease. Read More

View Article
December 2018

JAMA Ophthalmology.

Authors:

JAMA Ophthalmol 2018 Dec;136(12):1324

View Article
December 2018

Highlights.

Authors:

JAMA Ophthalmol 2018 Dec;136(12):1323

View Article
December 2018

Magnetic Resonance Imaging of a Medially Displaced Optic Nerve in a Rare Case of Extreme Exotropia.

JAMA Ophthalmol 2018 Dec 13;136(12):e183420. Epub 2018 Dec 13.

Department of Ophthalmology, Shaare Zedek Medical Center, Faculty of Medicine, Hebrew University, Jerusalem, Israel.

View Article
December 2018

Thyroid-Related Orbitopathy, Restrictive Strabismus, Dermopathy, and Acropachy.

JAMA Ophthalmol 2018 Dec 13;136(12):e183217. Epub 2018 Dec 13.

Division of Oculofacial Plastic and Reconstructive Surgery, Department of Ophthalmology, Shiley Eye Institute, University of California, San Diego.

View Article
December 2018

Cerulean Cataract.

JAMA Ophthalmol 2018 Dec 13;136(12):e183150. Epub 2018 Dec 13.

Department of Ophthalmology and Visual Sciences, University of Iowa, Iowa City.

View Article
December 2018

Coats Disease in a Young Adult Man.

JAMA Ophthalmol 2018 Dec 13;136(12):e183146. Epub 2018 Dec 13.

Department of Ophthalmology, Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, Taoyuan, Taiwan.

View Article
December 2018

Angioid Streaks Are Not a Common Feature of Ehlers Danlos Syndrome.

JAMA Ophthalmol 2018 Dec 13. Epub 2018 Dec 13.

Wilmer Eye Institute, Baltimore, Maryland.

View Article
December 2018

Comparison of Immediate vs Deferred Cytoreductive Nephrectomy in Patients with Synchronous Metastatic Renal Cell Carcinoma Receiving Sunitinib: The SURTIME Randomized Clinical Trial.

JAMA Oncol 2018 Dec 13. Epub 2018 Dec 13.

The Netherlands Cancer Institute, Amsterdam, the Netherlands.

Importance: In clinical practice, patients with primary metastatic renal cell carcinoma (mRCC) have been offered cytoreductive nephrectomy (CN) followed by targeted therapy, but the optimal sequence of surgery and systemic therapy is unknown.

Objective: To examine whether a period of sunitinib therapy before CN improves outcome compared with immediate CN followed by sunitinib.

Design, Setting, And Participants: This randomized clinical trial began as a phase 3 trial on July 14, 2010, and continued until March 24, 2016, with a median follow-up of 3. Read More

View Article
December 2018

Cost-effectiveness and Budgetary Consequence Analysis of Durvalumab Consolidation Therapy vs No Consolidation Therapy After Chemoradiotherapy in Stage III Non-Small Cell Lung Cancer in the Context of the US Health Care System.

JAMA Oncol 2018 Dec 13. Epub 2018 Dec 13.

Institute for Technology Assessment, Massachusetts General Hospital, Boston.

Importance: In early 2018, durvalumab became the first immunotherapy to be approved for adjuvant treatment of patients with unresectable stage III non-small cell lung cancer (NSCLC) whose cancer has not progressed after definitive chemoradiotherapy. However, the cost-effectiveness and potential economic implications of using this high-priced therapy in this indication are unknown to date.

Objective: To explore the cost-effectiveness and potential budgetary consequences of durvalumab consolidation therapy vs no consolidation therapy after chemoradiotherapy in stage III NSCLC in the context of the US health care system. Read More

View Article
December 2018

Development of a Retinopathy of Prematurity Activity Scale and Clinical Outcome Measures for Use in Clinical Trials.

JAMA Ophthalmol 2018 Dec 13. Epub 2018 Dec 13.

The Floating Hospital for Children, Tufts Medical Center, Boston, Massachusetts.

Importance: To facilitate drug and device development for neonates, the International Neonatal Consortium brings together key stakeholders, including pharmaceutical companies, practitioners, regulators, funding agencies, scientists, and families, to address the need for objective, standardized clinical trial outcome measurements to fulfill regulatory requirements. Retinopathy of prematurity (ROP) is a disease that affects preterm neonates. The current International Classification of Retinopathy of Prematurity does not take into account all of the characteristics of ROP and does not adequately discriminate small changes in disease after treatment. Read More

View Article
December 2018

Alpelisib Plus Fulvestrant in PIK3CA-Altered and PIK3CA-Wild-Type Estrogen Receptor-Positive Advanced Breast Cancer: A Phase 1b Clinical Trial.

JAMA Oncol 2018 Dec 13:e184475. Epub 2018 Dec 13.

Department of Medicine, University of California at San Francisco, Helen Diller Family Comprehensive Cancer Center, San Francisco.

Importance: The phosphatidylinositol 3-kinase (PI3K) pathway is frequently activated in patients with estrogen receptor-positive (ER+), endocrine therapy-resistant breast cancers.

Objective: To assess the maximum tolerated dose (MTD), safety, and activity of alpelisib, an oral, PI3Kα-specific inhibitor, plus fulvestrant in patients with ER+ advanced breast cancer (ABC).

Design, Setting, And Participants: An open-label, single-arm, phase 1b study of alpelisib plus fulvestrant was conducted at 10 centers in 5 countries. Read More

View Article
December 2018

Typographical Errors in Table 2 and Text.

Authors:

JAMA Oncol 2018 Dec 13. Epub 2018 Dec 13.

View Article
December 2018

Erythematous Macular Eruption in an Older Woman.

JAMA Oncol 2018 Dec 13. Epub 2018 Dec 13.

Department of Haematology, School of Medicine, University of Dundee, Ninewells Hospital, Dundee, Scotland.

View Article
December 2018

Assessment of Casual Observers' Willingness to Pay for Increased Attractiveness Through Rhinoplasty.

JAMA Facial Plast Surg 2018 Dec 13. Epub 2018 Dec 13.

Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.

Importance: Contingent valuation, or willingness to pay, is an established economic concept that has been applied in other areas of medicine and may be useful for understanding the economic forces that determine the cost of cosmetic procedures.

Objective: To determine the monetary value of changes in attractiveness achieved through rhinoplasty, as perceived by society.

Design, Setting, And Participants: Cross-sectional survey administered via public online forums to 228 casual observers. Read More

View Article
December 2018

Association of an Electronic Health Record-Linked Glaucoma Medical Reminder With Patient Satisfaction.

JAMA Ophthalmol 2018 Dec 13. Epub 2018 Dec 13.

Glaucoma Center of Excellence, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.

Importance: While dosing reminders for glaucoma medications have been shown to increase drug adherence, an outstanding limitation preventing broad adoption is difficulty linking reminders to medication in each patient's electronic health record (EHR).

Objective: To examine the feasibility of implementing an EHR-linked, automated reminder system for glaucoma medications and assess patient satisfaction with it.

Design, Setting, And Participants: In this prospective, cross-sectional study, patients receiving glaucoma medications were recruited from a university-based glaucoma clinic from April 2017 to January 2018. Read More

View Article
December 2018

JAMA Oncology.

Authors:

JAMA Oncol 2018 Dec;4(12):1641

View Article
December 2018

Highlights.

Authors:

JAMA Oncol 2018 Dec;4(12):1635

View Article
December 2018

Error in Figure 2.

Authors:

JAMA Oncol 2018 Dec;4(12):1792

View Article
December 2018

The "Lights On-Off Test" in the Diagnosis of the Dragged-Fovea Diplopia Syndrome.

Authors:
David L Guyton

JAMA Ophthalmol 2018 Dec 13. Epub 2018 Dec 13.

The Zanvyl Krieger Children's Eye Center at the Wilmer Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland.

View Article
December 2018

Error in Table.

Authors:

JAMA Ophthalmol 2018 Dec 13. Epub 2018 Dec 13.

View Article
December 2018

Choroidal Infiltrate of Unknown Cause.

JAMA Ophthalmol 2018 Dec 13. Epub 2018 Dec 13.

Retina Service, Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston.

View Article
December 2018

New Onset vs Resolution of Central-Peripheral Rivalry-Type Diplopia in Patients Undergoing Epiretinal Membrane Peeling.

JAMA Ophthalmol 2018 Dec 13. Epub 2018 Dec 13.

Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota.

Importance: The peeling of an epiretinal membrane (ERM) is commonly performed for poor visual acuity and/or metamorphopsia, but to our knowledge, its influence on central-peripheral rivalry (CPR)-type diplopia has not been rigorously studied.

Objective: To evaluate the occurrence of either resolution or new-onset CPR-type diplopia in patients undergoing ERM peeling.

Design, Setting, And Participants: This prospective cohort study was conducted from July 2014 to April 2018 at a tertiary referral medical center and included 33 adults with ERM who were undergoing peeling surgery with planned preoperative to postoperative analysis. Read More

View Article
December 2018

Suction Blisters.

JAMA Dermatol 2018 Dec 12. Epub 2018 Dec 12.

Department of Dermatology, University of California, San Francisco.

View Article
December 2018

Use of Combination Systemic-Intratumoral HPV Vaccine to Treat Cutaneous Basaloid Squamous Cell Carcinomas-Reply.

JAMA Dermatol 2018 Dec 12. Epub 2018 Dec 12.

Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Florida.

View Article
December 2018

Guidelines Do Not Proscribe Surgeons Performing Genetic Testing-Reply.

JAMA Surg 2018 Dec 12. Epub 2018 Dec 12.

Department of Medicine, Stanford University, Stanford, California.

View Article
December 2018

Guidelines Do Not Proscribe Surgeons Performing Genetic Testing.

JAMA Surg 2018 Dec 12. Epub 2018 Dec 12.

OasisMD Lifestyle Healthcare, San Diego, California.

View Article
December 2018

Incidence, Characteristics, and Outcomes of Myocardial Infarction in Patients With Peripheral Artery Disease: Insights From the EUCLID Trial.

JAMA Cardiol 2018 Dec 12. Epub 2018 Dec 12.

Stanford Center for Clinical Research, Department of Medicine, Stanford University School of Medicine, Stanford, California.

Importance: Patients with peripheral artery disease (PAD) are at high risk for myocardial infarction (MI).

Objective: To characterize the incidence and types of MI in a PAD population, identify factors associated with MI, and determine the association of MI with cardiovascular mortality and acute limb ischemia.

Design, Setting, And Participants: The Study Comparing Cardiovascular Effects of Ticagrelor and Clopidogrel in Patients With Peripheral Artery Disease (EUCLID) was a double-blind randomized clinical trial conducted at 811 sites in 28 countries that randomized 13 885 patients with symptomatic PAD to monotherapy with ticagrelor or clopidogrel. Read More

View Article
December 2018

Community-Based Approach to Trauma and Violence: Guns, Germs, and Bystanders.

JAMA Surg 2018 Dec 12. Epub 2018 Dec 12.

Department of Surgery, Northwestern University, Chicago, Illinois.

View Article
December 2018

Real-time Mobile Monitoring of the Dynamic Associations Among Motor Activity, Energy, Mood, and Sleep in Adults With Bipolar Disorder.

JAMA Psychiatry 2018 Dec 12. Epub 2018 Dec 12.

Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.

Importance: Biologic systems involved in the regulation of motor activity are intricately linked with other homeostatic systems such as sleep, feeding behavior, energy, and mood. Mobile monitoring technology (eg, actigraphy and ecological momentary assessment devices) allows the assessment of these multiple systems in real time. However, most clinical studies of mental disorders that use mobile devices have not focused on the dynamic associations between these systems. Read More

View Article
December 2018

Antipsychotics, Excess Deaths, and Paradoxes of Child Psychiatry.

Authors:
Barbara Geller

JAMA Psychiatry 2018 Dec 12. Epub 2018 Dec 12.

Department of Psychiatry, Washington University in St Louis, St Louis, Missouri.

View Article
December 2018

Highlights.

Authors:

JAMA Dermatol 2018 Dec;154(12):1371

View Article
December 2018

Association of Antipsychotic Treatment With Risk of Unexpected Death Among Children and Youths.

JAMA Psychiatry 2018 Dec 12. Epub 2018 Dec 12.

Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee.

Importance: Children and youths who are prescribed antipsychotic medications have multiple, potentially fatal, dose-related cardiovascular, metabolic, and other adverse events, but whether or not these medications are associated with an increased risk of death is unknown.

Objective: To compare the risk of unexpected death among children and youths who are beginning treatment with antipsychotic or control medications.

Design, Setting, And Participants: This retrospective cohort study was conducted from 1999 through 2014 and included Medicaid enrollees aged 5 to 24 years in Tennessee who had no diagnosis of severe somatic illness, schizophrenia or related psychoses, or Tourette syndrome or chronic tic disorder. Read More

View Article
December 2018
2 Reads

Association of Screening and Treatment for Preoperative Asymptomatic Bacteriuria With Postoperative Outcomes Among US Veterans.

JAMA Surg 2018 Dec 12. Epub 2018 Dec 12.

Department of Medicine, VA Boston Healthcare System, Boston, Massachusetts.

Importance: Limited data suggest that screening for asymptomatic bacteriuria (ASB) prior to nonurologic procedures is not useful. However, high-quality evidence to support consensus recommendations and influence clinical practice is lacking.

Objective: To characterize the association between detection and treatment of preoperative ASB and postoperative outcomes. Read More

View Article
December 2018
1 Read