6,809 results match your criteria JAIDS: Journal of Acquired Immune Deficiency Syndromes[Journal]


Impact of PrEP Training for Family Planning Providers on HIV Prevention Counseling and Patient Interest in PrEP in Atlanta, Georgia.

J Acquir Immune Defic Syndr 2019 Apr 11. Epub 2019 Apr 11.

Department of Medicine, Division of Infectious Diseases, Emory University School of Medicine.

Background: Safety net family planning clinics provide vital care for women in high HIV burden areas and may be ideal PrEP delivery sites. Yet, many family planning providers lack knowledge about PrEP.

Setting: Four safety net family planning clinics in Atlanta, Georgia. Read More

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http://dx.doi.org/10.1097/QAI.0000000000002057DOI Listing
April 2019
1 Read

Predictors of Disengagement in Care for Individuals Receiving Pre-Exposure Prophylaxis (PrEP).

J Acquir Immune Defic Syndr 2019 Apr 11. Epub 2019 Apr 11.

Assistant Professor, Division of Infectious Diseases, Department of Internal Medicine Columbia University Medical Center, New York, NY, USAAssistant Professor, Division of Infectious Diseases, Department of Internal Medicine Columbia University Medical Center, New York, NY, USA.

Background: HIV pre-exposure prophylaxis (PrEP) reduces incident HIV infections, but efficacy depends on adherence and retention, among other factors. Substance use disorders, un-met mental health needs, and demographic factors are associated with non-adherence in HIV-infected patients; we studied whether these affect PrEP loss-to-follow-up.

Methods: To investigate potential risk factors for non-adherence with PrEP and loss-to-follow-up in a comprehensive HIV prevention program, we conducted a retrospective cohort analysis of individuals starting tenofovir-emtricitabine between 1/1/2015 and 11/30/2017. Read More

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http://dx.doi.org/10.1097/QAI.0000000000002054DOI Listing
April 2019
1 Read

Switching to Doravirine/Lamivudine/Tenofovir Disoproxil Fumarate (DOR/3TC/TDF) Maintains HIV-1 Virologic Suppression Through 48 Weeks: Results of the DRIVE-SHIFT Trial.

J Acquir Immune Defic Syndr 2019 Apr 11. Epub 2019 Apr 11.

Merck & Co., Inc., Kenilworth, NJ USA.

Background: Doravirine is a novel, non-nucleoside reverse transcriptase inhibitor (NNRTI) with demonstrated efficacy in treatment-naïve adults with HIV-1.

Methods: In this open-label, active-controlled, non-inferiority trial, adults with HIV-1 virologically suppressed for ≥6 months on 2 NRTIs plus a boosted protease inhibitor (PI), boosted elvitegravir, or an NNRTI were randomized (2:1) to switch to once-daily, single-tablet doravirine 100mg with lamivudine 300mg and tenofovir disoproxil fumarate 300mg (DOR/3TC/TDF) or to continue their current therapy (Baseline Regimen) for 24 weeks. The primary endpoint was the proportion of participants with HIV-1 RNA <50 copies/mL (FDA Snapshot approach), with the primary comparison between DOR/3TC/TDF at week 48 and Baseline Regimen at week 24, and a secondary comparison between the groups at week 24 (non-inferiority margin, -8%). Read More

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http://dx.doi.org/10.1097/QAI.0000000000002056DOI Listing
April 2019
1 Read

Differences between groups of pre-exposure prophylaxis (PrEP) using couples in HIV-negative/unknown relationships.

J Acquir Immune Defic Syndr 2019 Apr 11. Epub 2019 Apr 11.

Center for HIV/AIDS Educational Studies & Training, Hunter College of the City University of New York (CUNY), New York, NY, USA.

Background: Epidemiology research is limited on the characteristics of HIV pre-exposure prophylaxis (PrEP) using couples.

Setting: United States nationwide sample recruited online in 2017.

Methods: HIV-negative/unknown gay, bisexual, and other men who have sex with men (GBMSM) with HIV-negative/unknown partners (n=3140) were asked about individual and main partner PrEP uptake. Read More

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http://dx.doi.org/10.1097/QAI.0000000000002058DOI Listing

HIV pre-exposure prophylaxis (PrEP) uptake among gay and bisexual men in Australia and factors associated with the non-use of PrEP among eligible men: Results from a prospective cohort study.

J Acquir Immune Defic Syndr 2019 Apr 4. Epub 2019 Apr 4.

The Kirby Institute, UNSW Sydney, Australia.

Background: HIV pre-exposure prophylaxis (PrEP) is a highly effective biomedical HIV prevention strategy, yet some gay and bisexual men (GBM) who are eligible to access PrEP are not using it. We report the incidence of PrEP uptake, factors predicting its initiation, and identify characteristics associated with non-uptake of PrEP among Australian GBM who meet the eligibility criteria.

Methods: The Following Lives Undergoing Change (Flux) Study is a national, online, prospective observational study among GBM focusing on licit and illicit drug use. Read More

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http://dx.doi.org/10.1097/QAI.0000000000002047DOI Listing

Sustained Effect of a Community-based Behavioral and Nutrition Intervention on HIV-related Outcomes among Women living with HIV in Rural India: A Quasi-experimental Trial.

J Acquir Immune Defic Syndr 2019 Apr 4. Epub 2019 Apr 4.

University of California, San Francisco, 505 Parnassus Ave, San Francisco, CA 94143, USA.

Background: Women living with HIV (WLH) in rural communities face challenges to obtaining treatment and accurate disease-related information. Nutritional deficits exacerbate disease progression.

Setting: WLH were recruited from primary-health centers in rural India. Read More

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http://dx.doi.org/10.1097/QAI.0000000000002044DOI Listing

HIV positivity and referral to treatment following index testing of partners and children of HIV-infected patients in public sector facilities in South Africa.

J Acquir Immune Defic Syndr 2019 Apr 4. Epub 2019 Apr 4.

BroadReach Healthcare, Cape Town, South Africa.

Background: There is an imperative need for innovative interventions to identify people living with HIV and initiate them on antiretroviral therapy (ART). The objective of this study was to determine the feasibility of providing index partner/child testing of people living with HIV.

Methods: We trained 86 nurses and counsellors in 56 public health facilities in six high HIV burden Districts in 2017 to provide index partner/child testing (tracing and testing of partners/children of people living with HIV). Read More

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http://dx.doi.org/10.1097/QAI.0000000000002048DOI Listing

High incidence of intended partner pregnancy among men living with HIV in rural Uganda: Implications for safer conception services.

J Acquir Immune Defic Syndr 2019 Apr 15. Epub 2019 Apr 15.

MGH Global Health and Division of Infectious Diseases, Boston, USA.

Background: Many men with HIV express fertility intentions and nearly half have HIV-uninfected sexual partners. We measured partner pregnancy among a cohort of men accessing antiretroviral therapy (ART) in Uganda.

Methods: Self-reported partner pregnancy incidence and bloodwork (CD4, HIV-RNA) were collected quarterly. Read More

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http://dx.doi.org/10.1097/QAI.0000000000002053DOI Listing

ART in HIV-positive persons with low pre-treatment viremia: results from the START trial.

J Acquir Immune Defic Syndr 2019 Apr 15. Epub 2019 Apr 15.

Kirby Institute, University of New South Wales, Australia.

Background: The benefit of immediate antiretroviral therapy (ART) at CD4 >500 cells/ìL was established in the Strategic Timing of Antiretroviral Treatment (START) study. The benefits and risks of immediate ART in participants with low pre-treatment viremia, including virologic suppressors, was further assessed.

Setting: Randomized prospective international study METHODS:: START participants with enrollment viremia <3000c/mL were included. Read More

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http://dx.doi.org/10.1097/QAI.0000000000002052DOI Listing

Current US Guidelines for Prescribing HIV Pre-Exposure Prophylaxis (PrEP) Disqualify Many Women Who Are at Risk and Motivated to Use PrEP.

J Acquir Immune Defic Syndr 2019 Apr 15. Epub 2019 Apr 15.

Department of Social and Behavioral Sciences, Yale School of Public Health, Yale University, New Haven, CT, USA.

Background: US Centers for Disease Control and Prevention (CDC) clinical guidelines for HIV pre-exposure prophylaxis (PrEP) are widely utilized to assess patients' PrEP eligibility. The guidelines include two versions of criteria - guidance summary criteria and recommended indications criteria - that diverge in a potentially critical way for heterosexually active women: Both require women's knowledge of their own risk behavior, but the recommended indications also require women's knowledge of their partners' HIV risk or recognition of a potentially asymptomatic sexually transmitted infection (STI). This study examined women's PrEP eligibility according to these two different versions of criteria across risk and motivation categories. Read More

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http://dx.doi.org/10.1097/QAI.0000000000002042DOI Listing
April 2019
3 Reads

Adherence to PrEP among young men who have sex with men participating in a sexual health services demonstration project in Alameda County, California.

J Acquir Immune Defic Syndr 2019 Apr 15. Epub 2019 Apr 15.

Alta Bates Summit Medical Center, University of California, Berkeley and San Francisco.

Background: Young men of color who have sex with men (YMSM) face a continual increase in rates of HIV infection. Pre-exposure prophylaxis (PrEP) is an important prevention method for these young men.

Setting: The Connecting Resources for Urban Sexual Health (CRUSH) demonstration project provided sexual health services, including PrEP, to YMSM aged 18-29. Read More

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http://dx.doi.org/10.1097/QAI.0000000000002051DOI Listing
April 2019
1 Read

HIV Disease Severity is Sensitive to Temporal Changes in Alcohol Use: A National Study of VA Patients with HIV.

J Acquir Immune Defic Syndr 2019 Apr 15. Epub 2019 Apr 15.

Health Services Research & Development (HSR&D), Center of Innovation for Veteran-Centered Value-Driven Care, Veteran Affairs (VA ) Puget Sound Health Care System, Seattle, WA.

Background: Alcohol use influences HIV disease severity via multiple mechanisms. Whether HIV disease severity is sensitive to changes in alcohol use among people with HIV (PWH) is understudied.

Setting: National Veterans Health Administration. Read More

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http://dx.doi.org/10.1097/QAI.0000000000002049DOI Listing
April 2019
1 Read

HIV, Elevated Transaminases, Fatty Liver: The Perfect Storm?

J Acquir Immune Defic Syndr 2019 May;81(1):e23-e25

Division of Gastroenterology and Hepatology, Royal Victoria Hospital, McGill University Health Centre, Montreal, Québec, Canada.

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http://dx.doi.org/10.1097/QAI.0000000000001984DOI Listing

Cytomegalovirus Viremia in HIV-1 Subtype C Positive Women at Delivery in Botswana and Adverse Birth/Infant Health Outcomes.

J Acquir Immune Defic Syndr 2019 May;81(1):118-124

Research Laboratory, Botswana Harvard AIDS Institute Partnership, Gaborone, Botswana.

Background: We evaluated the association between maternal cytomegalovirus (CMV) viremia during pregnancy and adverse birth and infant health outcomes in HIV-infected mothers and their HIV-exposed uninfected infants.

Methods: HIV-positive women and their infants were followed prospectively from pregnancy through 2 years postpartum in the "Tshipidi" study in Botswana. We analyzed the association between detectable CMV DNA in maternal blood at delivery and adverse birth outcomes (stillbirth, preterm delivery, small for gestational age, or birth defect), as well as infant hospitalization and mortality through 24 months. Read More

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http://dx.doi.org/10.1097/QAI.0000000000001982DOI Listing
May 2019
6 Reads

Changes in Disparities in Estimated HIV Incidence Rates Among Black, Hispanic/Latino, and White Men Who Have Sex With Men (MSM) in the United States, 2010-2015.

J Acquir Immune Defic Syndr 2019 May;81(1):57-62

Division of HIV/AIDS Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD and TB Prevention, Atlanta, Georgia.

Background: During 2008-2015, the estimated annual HIV incidence rate in the United States decreased for each transmission risk category, except for men who have sex with men (MSM). Racial/ethnic disparities exist, with higher incidence rates for Black and Hispanic/Latino MSM.

Setting: This analysis examines changes, 2010-2015, in disparities of HIV incidence among Black, Hispanic/Latino and White MSM. Read More

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http://dx.doi.org/10.1097/QAI.0000000000001977DOI Listing
May 2019
3 Reads

How Can Programs Better Support Female Sex Workers to Avoid HIV Infection in Zimbabwe? A Prevention Cascade Analysis.

J Acquir Immune Defic Syndr 2019 May;81(1):24-35

Department of Social and Environmental Health Research, Public Health and Policy, London School of Hygiene and Tropical Medicine, London, United Kingdom.

Background: "HIV prevention cascades" have been proposed to support programs by identifying gaps in demand for, access to, and capability to adhere to HIV prevention tools, but there are few empirical examples to guide development. We apply a prevention cascade framework to examine prevention coverage and factors associated with condoms and/or PrEP adherence among female sex workers.

Setting: Seven sites across Zimbabwe. Read More

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http://dx.doi.org/10.1097/QAI.0000000000001980DOI Listing
May 2019
1 Read
4.556 Impact Factor

HIV-Related Deaths in Nairobi, Kenya: Results From a HIV Mortuary Surveillance Study, 2015.

J Acquir Immune Defic Syndr 2019 May;81(1):18-23

National AIDS and STI Control Programme, Ministry of Health, Nairobi, Kenya.

Background: Death is an important but often unmeasured endpoint in public health HIV surveillance. We sought to describe HIV among deaths using a novel mortuary-based approach in Nairobi, Kenya.

Methods: Cadavers aged 15 years and older at death at Kenyatta National Hospital (KNH) and City Mortuaries were screened consecutively from January 29 to March 3, 2015. Read More

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http://dx.doi.org/10.1097/QAI.0000000000001975DOI Listing
May 2019
1 Read

Early outcomes of a high-resolution anoscopy-based anal cancer screening program among people with HIV enrolled in an integrated healthcare system.

J Acquir Immune Defic Syndr 2019 Mar 29. Epub 2019 Mar 29.

Kaiser Permanente Northern California, Division of Research.

Background: Few studies have examined outcomes of high-resolution anoscopy (HRA)-based screening for people with HIV infection (PWH), a population at increased risk for anal cancer. SETTING00:: Large integrated healthcare system.

Methods: Cohort study of 13,552 PWH, comparing incidences of anal cancer and advanced anal cancer (higher stage, recurrence, death or surgical salvage) before and after high-resolution anoscopy (HRA) became available (2008). Read More

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http://dx.doi.org/10.1097/QAI.0000000000002040DOI Listing
March 2019
1 Read

Hazardous Cannabis Use and Monocyte Activation Among Methamphetamine Users with Treated HIV Infection.

J Acquir Immune Defic Syndr 2019 Apr 3. Epub 2019 Apr 3.

University of Miami School of Medicine.

Background: The use of stimulants, such as methamphetamine, has been associated with greater immune activation in treated HIV infection. However, relatively little is known about whether concomitant cannabis use is associated with lower immune activation among HIV-positive stimulant users.

Setting: HIV-positive, sexual minority men with biologically confirmed, recent methamphetamine use were enrolled in San Francisco, California. Read More

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http://dx.doi.org/10.1097/QAI.0000000000002046DOI Listing
April 2019
3 Reads

Cognitive and Motor Impairment Severity Related to Signs of Subclinical Wernicke's Encephalopathy in HIV Infection.

J Acquir Immune Defic Syndr 2019 Apr 3. Epub 2019 Apr 3.

Department of Psychiatry and Behavioral Sciences Stanford University School of Medicine, Stanford, CA 94305, USA.

Background: Wernicke's encephalopathy (WE) is a neurological condition resulting from thiamine deficiency. Although commonly associated with alcoholism, non-alcoholic WE has been described in individuals with Human Immunodeficiency Virus (HIV) infection, but subclinical WE may be underdiagnosed. The current study questioned whether presence of subclinical WE signs underlies cognitive and motor deficits in HIV individuals as observed in alcoholism. Read More

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http://dx.doi.org/10.1097/QAI.0000000000002043DOI Listing
April 2019
1 Read

Risk and predictors of esophageal and stomach cancers in HIV-infected veterans: A matched cohort study.

J Acquir Immune Defic Syndr 2019 Mar 29. Epub 2019 Mar 29.

Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX.

Background: Evaluate the risks of esophageal and stomach carcinomas in people living with HIV (PLWH) compared with the general population as well as risk factors for these cancers in PLWH.

Setting: Retrospective cohort study in the Veterans Health Administration.

Methods: We compared incidence rates for esophageal and stomach cancers in 44,075 HIV-infected male veterans with those in a matched HIV-uninfected cohort (N=157,705; 4:1 matched on age and HIV-index date). Read More

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http://dx.doi.org/10.1097/QAI.0000000000002038DOI Listing
March 2019
8 Reads

Pregnancy and Neonatal Outcomes Following Prenatal Exposure to Dolutegravir.

J Acquir Immune Defic Syndr 2019 Mar 29. Epub 2019 Mar 29.

UCL Great Ormond Street Institute of Child Health, London, UK.

Background: Birth outcomes data with dolutegravir exposure during pregnancy, particularly in the first trimester, are needed.

Setting: Data were prospectively collected from the Antiretroviral Pregnancy Registry and European Pregnancy and Paediatric HIV Cohort Collaboration.

Methods: We reviewed 2 large, independent antiretroviral pregnancy registries to assess birth outcomes associated with maternal dolutegravir treatment during pregnancy. Read More

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http://dx.doi.org/10.1097/QAI.0000000000002035DOI Listing
March 2019
1 Read

Plasma Cystatin C Associates with HIV-Associated Neurocognitive Disorder but is a Poor Diagnostic Marker in Antiretroviral Therapy Treated Individuals.

J Acquir Immune Defic Syndr 2019 Mar 27. Epub 2019 Mar 27.

Northwestern University School of Medicine, Chicago, IL, US.

Objective: To examine associations between plasma cystatin C and neurocognitive impairment (NCI), and its performance as a diagnostic marker before and during initial antiretroviral therapy (ART).

Methods: Multivariable logistic regression and generalized estimating equations (GEE) examined associations with NCI, determined by neuropsychological measurements, in participants of a 48-week randomized clinical trial of initial ART. Receiver operator characteristic (ROC) curves examined diagnostic models of NCI. Read More

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http://dx.doi.org/10.1097/QAI.0000000000002016DOI Listing

Impact of HIV-status disclosure on HIV viral load in pregnant and postpartum women on antiretroviral therapy.

J Acquir Immune Defic Syndr 2019 Mar 29. Epub 2019 Mar 29.

Division of Epidemiology & Biostatistics, School of Public Health & Family Medicine, University of Cape Town, Cape Town, South Africa.

Background: HIV-status disclosure is widely encouraged by counselling services, in part because it is thought to improve antiretroviral therapy (ART) adherence and thus HIV viral suppression. However, few longitudinal studies have examined the impact of disclosure on HIV viral load (VL) during pregnancy and postpartum.

Methods: We explored these associations among 1187 women living with HIV, enrolled between March 2013 and June 2014 in Cape Town, South Africa. Read More

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http://dx.doi.org/10.1097/QAI.0000000000002036DOI Listing
March 2019
6 Reads

Proteinuria is Associated with Increased Risk of Fragility Fracture in Men With or at Risk for HIV infection Proteinuria and Fracture Risk Association.

J Acquir Immune Defic Syndr 2019 Mar 29. Epub 2019 Mar 29.

Johns Hopkins University.

Background: Proteinuria has been associated with bone loss and fractures in general population but data in HIV-infected population is lacking.

Setting: Prospective, multicenter cohort study of men with or at risk for HIV infection.

Methods: Between 2006 and 2015, urine protein measurements and bone fracture histories were ascertained semi-annually in 947 HIV-infected (HIV+) and 969 HIV-uninfected (HIV-) men ≥ age 40. Read More

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http://dx.doi.org/10.1097/QAI.0000000000002039DOI Listing
March 2019
1 Read

Evaluation of Neural Tube Defects (NTD) After Exposure to Raltegravir During Pregnancy.

J Acquir Immune Defic Syndr 2019 Mar 19. Epub 2019 Mar 19.

Department of Clinical Safety and Risk Management.

Objective: To evaluate the risk of neural tube defects (NTDs) after exposure to raltegravir during pregnancy.

Methods: Exposures to raltegravir during pregnancy reported cumulatively through 31-May-2018 to the company safety database were reviewed to identify cases of NTDs. This database includes all reports of pregnancy from Merck-sponsored clinical trials, spontaneous post-marketing and non-interventional data sources, including the Antiretroviral Pregnancy Registry (APR). Read More

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http://dx.doi.org/10.1097/QAI.0000000000002031DOI Listing
March 2019
1 Read

Associations between lifetime traumatic experiences and HIV-risk behaviours amongst young men living in informal settlements in South Africa: A cross-sectional analysis and structural equation model.

J Acquir Immune Defic Syndr 2019 Mar 6. Epub 2019 Mar 6.

School of Public Health, University of Witwatersrand, Johannesburg, South Africa.

Background: Qualitative research emphasizes men's experiences of trauma increase HIV-risk. We seek to understand associations between experience of traumatic events and HIV-risk behaviours amongst heterosexual men in two trials in urban informal settlements in South Africa.

Methods: Cross-sectional surveys among men in Johannesburg and Durban, South Africa, enrolled in intervention trials. Read More

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http://dx.doi.org/10.1097/QAI.0000000000002010DOI Listing

Elevated depressive symptoms are a stronger predictor of executive dysfunction in HIV-infected women than men.

J Acquir Immune Defic Syndr 2019 Mar 8. Epub 2019 Mar 8.

Departments of Psychiatry and Psychology, University of Illinois at Chicago College of Medicine.

Background: HIV-infected (HIV+) women appear to be more vulnerable to neurocognitive impairment than HIV+ men, perhaps in part due to mental health factors. We assessed the association between elevated depressive symptoms and NCI among HIV+ and HIV-uninfected (HIV-) women and men.

Setting: Women's Interagency HIV Study (WIHS) and Multicenter AIDS Cohort Study (MACS). Read More

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http://Insights.ovid.com/crossref?an=00126334-900000000-9641
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http://dx.doi.org/10.1097/QAI.0000000000002029DOI Listing
March 2019
3 Reads

A comparison of plasma efavirenz and tenofovir, dried blood spot tenofovir-diphosphate, and self-reported adherence to predict virologic suppression among South African women.

J Acquir Immune Defic Syndr 2019 Mar 8. Epub 2019 Mar 8.

Division of Clinical of Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa.

Background: Tenofovir-diphosphate (TFV-DP) in dried blood spots (DBS) is an objective long-term adherence measure but data are limited on its ability to predict virologic suppression (VS) in people on antiretroviral (ARV) treatment. There are also no data comparing DBS TFV-DP with plasma ARV concentrations as predictors of VS.

Methods: Women who were on a first-line regimen of tenofovir, emtricitabine, and efavirenz (EFV) were enrolled in a cross-sectional study. Read More

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http://dx.doi.org/10.1097/QAI.0000000000002032DOI Listing

Discrimination, medical distrust, stigma, depressive symptoms, antiretroviral medication adherence, engagement in care and quality of life among women living with HIV in North Carolina: a mediated structural equation model.

J Acquir Immune Defic Syndr 2019 Mar 8. Epub 2019 Mar 8.

Professor of Medicine, School of Medicine & Professor of Epidemiology, Gillings School of Global Public Health The University of North Carolina at Chapel Hill Chapel Hill, NC.

Background: Women represent 23% of all Americans living with HIV. By 2020, more than 70% of Americans living with HIV are expected to be 50 and older.

Setting: This study was conducted in the Southern US - a geographic region with the highest number of new HIV infections and deaths. Read More

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http://dx.doi.org/10.1097/QAI.0000000000002033DOI Listing

Impact of Integrase Inhibition compared to non-nucleoside inhibition on HIV reservoirs in Lymphoid Tissues.

J Acquir Immune Defic Syndr 2019 Mar 15. Epub 2019 Mar 15.

Department of Medicine, University of Minnesota, Minneapolis, MN, USA.

Background: HIV is produced in lymphoid tissues (LT) and stored on the follicular dendritic cell network in LT. When antiretroviral therapy (ART) is started, plasma viremia decays in two phases; the first within days of starting therapy and the second over weeks. Raltegravir (RAL), an integrase inhibitor, has been associated with only a single rapid phase of decay and we speculated this might be due to higher cell-associated concentration (IC) of RAL in LT. Read More

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http://dx.doi.org/10.1097/QAI.0000000000002026DOI Listing
March 2019
3 Reads

Brief Report: Response to Hepatitis A Virus Vaccine in HIV-Infected Patients Within a Retrospective, Multicentric Cohort: Facing Hepatitis A Outbreaks in the Clinical Practice.

J Acquir Immune Defic Syndr 2019 May;81(1):e1-e5

Unit of Infectious Diseases, Microbiology and Preventive Medicine, Hospital Universitario Virgen del Rocío, Sevilla, Spain.

Background: Various recent outbreaks of hepatitis A virus (HAV) have been described in men who have sex with men despite the availability of an effective vaccine. This study aimed to determine the current rates of seroconversion after receiving HAV vaccine (HAV-V) in HIV-infected patients under real-life conditions.

Setting: Patients were selected from a Southern Spanish multicentric cohort of HIV-infected subjects. Read More

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http://dx.doi.org/10.1097/QAI.0000000000001990DOI Listing
May 2019
4 Reads

Predicting virological response to HIV treatment over time: a tool for settings with different definitions of virological response.

J Acquir Immune Defic Syndr 2019 Feb 14. Epub 2019 Feb 14.

The HIV Resistance Response Database Initiative (RDI), London UK.

Objective: Definitions of virological response vary from <50 up to 1,000 copies HIV RNA/mL. Our previous models estimate the probability of HIV drug combinations reducing the viral load to <50 copies/mL with no indication of whether higher thresholds of response might be achieved. Here we describe the development of models that predict absolute viral load over time. Read More

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http://dx.doi.org/10.1097/QAI.0000000000001989DOI Listing
February 2019
1 Read

Characterizing the Influence of Structural Determinants of HIV Risk on Consistent Condom Use Among Female Sex Workers in Senegal.

J Acquir Immune Defic Syndr 2019 May;81(1):63-71

Department of Epidemiology, Key Populations Program, Center for Public Health and Human Rights, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.

Background: Female sex workers (FSWs) are disproportionately affected by HIV even in the most generalized HIV epidemics. Although structural HIV risks have been understood to affect condom negotiation among FSWs globally, there remain limited data on the relationship between structural determinants of HIV risk, including violence and socioeconomic status, and condom use among FSWs across sub-Saharan Africa. Here, we describe the prevalence of structural determinants and their associations with condom use among FSWs in Senegal. Read More

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http://dx.doi.org/10.1097/QAI.0000000000001991DOI Listing
May 2019
3 Reads

Effect of HIV Subtype and Antiretroviral therapy on HIV-associated neurocognitive disorder (HAND) stage in Rakai, Uganda.

J Acquir Immune Defic Syndr 2019 Feb 15. Epub 2019 Feb 15.

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.

Background: Combination antiretroviral therapy (ART) improves HIV-associated neurocognitive disorder (HAND) stage in the US where subtype B predominates, but the effect of ART and subtype on HAND stage in individuals in Uganda with subtypes D and A is largely unknown.

Setting: A community-based cohort of participants residing in Rakai, Uganda.

Methods: 399 initially ART-naive HIV-seropositive (HIV+) individuals were followed over two years. Read More

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http://dx.doi.org/10.1097/QAI.0000000000001992DOI Listing
February 2019
4 Reads

Human Immunodeficiency Virus and Fatty Liver: The Perfect Storm or a Storm in a Teacup?

J Acquir Immune Defic Syndr 2019 May;81(1):e25-e26

UCL Institute for Liver and Digestive Health, Royal Free Hospital and UCL, London, United Kingdom.

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http://dx.doi.org/10.1097/QAI.0000000000001995DOI Listing
May 2019
4 Reads

Measuring adherence to antiretroviral therapy via hair concentrations in India.

J Acquir Immune Defic Syndr 2019 Feb 20. Epub 2019 Feb 20.

Department of Medicine, St. John's Research Institute, St. John's National Academy of Health Sciences, Bangalore, India.

Background: Objective adherence measures are of increasing interest in antiretroviral treatment (ART) monitoring. Hair ART levels predict virologic suppression and hair is easy to collect and store. No prior study has examined hair levels in an India-based cohort or laboratory. Read More

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http://dx.doi.org/10.1097/QAI.0000000000001993DOI Listing
February 2019
4 Reads

Marijuana Use is Not Associated with Changes in Opioid Prescriptions or Pain Severity Among People Living with HIV and Chronic Pain.

J Acquir Immune Defic Syndr 2019 Feb 20. Epub 2019 Feb 20.

Center for Research on Healthcare, Divisions of General Internal Medicine and Infectious Diseases, University of Pittsburgh School of Medicine, Pennsylvania.

Background: People living with HIV (PLWH) commonly report marijuana use for chronic pain, though there is limited empirical evidence to support its use. There is hope that marijuana may reduce prescription opioid use. Our objective was to investigate whether marijuana use among PLWH who have chronic pain is associated with changes in pain severity and prescribed opioid use (prescribed opioid initiation and discontinuation). Read More

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http://dx.doi.org/10.1097/QAI.0000000000001998DOI Listing
February 2019

Detecting Disengagement from HIV Care Before It's Too Late: Development and Preliminary Validation of a Novel Index of Engagement in HIV Care.

J Acquir Immune Defic Syndr 2019 Feb 20. Epub 2019 Feb 20.

Associate Professor Department of Medicine Zuckerberg San Francisco General Hospital University of California San Francisco 995 Potrero Ave, 4 Floor San Francisco CA 94110

Background: Engagement in care is critical to achieving and sustaining optimal benefits of efficacious antiretroviral therapies (ART) for HIV infection. Current metrics of engagement in care, including problematic patterns of retention in care, adherence to treatment, and viral suppression, are often detected late in the disengagement process. We sought to develop and validate a patient-centered screener of engagement in care that can be used to identify deficits in patient perceptions of engagement prior to the development of poor outcomes, including loss to follow-up, treatment nonadherence, virologic failure, and the resulting increased likelihood of HIV-associated morbidity and mortality and onward transmission of HIV. Read More

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http://dx.doi.org/10.1097/QAI.0000000000002000DOI Listing
February 2019

Factors Associated with Excess Myocardial Infarction Risk in HIV-infected Adults: a Systematic Review and Meta-Analysis.

J Acquir Immune Defic Syndr 2019 02 20. Epub 2019 Feb 20.

Hubert Department of Global Health, Emory University 1518 Clifton Rd, Atlanta, GA 30322, CNR Building Room 7040.

Objectives: To estimate the pooled relative risk of incident acute myocardial infraction (AMI) among HIV-infected adults compared to HIV-uninfected controls and explore the contribution of traditional and HIV-related risk factors.

Background: Understanding AMI risk and associated risk factors in HIV-infected populations has the potential to inform clinical management and prevention strategies.

Methods: We systematically identified cohort studies of HIV-infected or HIV-infected and matched uninfected adults reporting AMI incidence rates published up to January 1, 2017. Read More

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http://dx.doi.org/10.1097/QAI.0000000000001996DOI Listing
February 2019
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4.556 Impact Factor

Brief Report: Kidney Dysfunction Does Not Contribute Significantly to Antiretroviral Therapy Modification in Treatment-Naive PLWH Receiving Initial ART.

J Acquir Immune Defic Syndr 2019 May;81(1):e6-e9

Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL.

Background: Antiretroviral therapy (ART) durability, time to modification or cessation, has declined. The study objective was to determine whether kidney dysfunction is contributing to reduced durability.

Methods: This retrospective follow-up study of CNICS evaluated treatment-naive PLWH initiating ART between 2007 and 2014. Read More

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http://dx.doi.org/10.1097/QAI.0000000000001999DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456383PMC

Brief Report: Real-World Performance and Interobserver Agreement of Urine Lipoarabinomannan in Diagnosing HIV-Associated Tuberculosis in an Emergency Center.

J Acquir Immune Defic Syndr 2019 May;81(1):e10-e14

Department of Medicine, Centre for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.

Background: The urine lipoarabinomannan (LAM) lateral flow assay is a point-of-care test to diagnose HIV-associated tuberculosis (TB). We assessed the performance of urine LAM in HIV-positive patients presenting to the emergency center and evaluated the interobserver agreement between emergency center physicians and laboratory technologists.

Setting: A cross-sectional diagnostic study was performed at the emergency center of a district hospital in a high HIV-prevalence community in South Africa. Read More

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http://dx.doi.org/10.1097/QAI.0000000000002002DOI Listing

Predictors of Long Term HIV Pre Exposure Prophylaxis Adherence after Study Participation in Men who have Sex with Men.

J Acquir Immune Defic Syndr 2019 Feb 21. Epub 2019 Feb 21.

University of California San Diego (UCSD), San Diego, California, United States.

Background: Efficacy of HIV pre-exposure prophylaxis (PrEP) among men who have sex with men (MSM) is well documented in randomized trials. Following trial completion, participants are challenged with acquiring PrEP on their own, and remaining adherent.

Methods: This was a follow-up study of the TAPIR randomized controlled multi-center PrEP trial. Read More

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http://dx.doi.org/10.1097/QAI.0000000000002003DOI Listing
February 2019
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Short-Term Adherence Marker to PrEP Predicts Future Non-Retention in a Large PrEP Demo Project: Implications for Point-of-Care Adherence Testing.

J Acquir Immune Defic Syndr 2019 Feb 21. Epub 2019 Feb 21.

San Francisco Department of Public Health, San Francisco, U.S.

Background: Objective adherence metrics for tenofovir (TFV) disoproxil fumarate/emtricitabine(FTC)-based PrEP were critical for interpretation of efficacy in PrEP clinical trials, and there is increasing interest in using drug levels to tailor interventions for reengagement and adherence. Point-of-care immunoassays (POC) for TFV, which examine short-term adherence, are in development. However the ability of poor short-term and long-term adherence to predict future PrEP non-retention is unknown. Read More

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http://dx.doi.org/10.1097/QAI.0000000000002005DOI Listing
February 2019

A longitudinal study of behavioral risk, adherence and virologic control in adolescents living with HIV in Asia.

J Acquir Immune Defic Syndr 2019 Feb 21. Epub 2019 Feb 21.

The HIV Netherlands Australia Thailand Research Collaboration (HIV-NAT), The Thai Red Cross AIDS Research Centre, Bangkok, Thailand.

Background: Adolescents living with HIV (ALHIV) have poorer adherence and clinical outcomes than adults. We conducted a study to assess behavioral risks and antiretroviral therapy (ART) outcomes among ALHIV in Asia.

Methods: A prospective cohort study among ALHIV and matched HIV-uninfected controls aged 12 to 18 years was conducted at nine sites in Malaysia, Thailand and Vietnam from July 2013-March 2017. Read More

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http://dx.doi.org/10.1097/QAI.0000000000002008DOI Listing
February 2019

Brief Report: Assessing the impact of race on HIV/STI risk perceptions among young men who have sex with men using an experimental approach.

J Acquir Immune Defic Syndr 2019 Feb 21. Epub 2019 Feb 21.

Center for Interdisciplinary Inquiry & Innovation in Sexual and Reproductive Health, Department of Obstetrics & Gynecology, University of Chicago.

Background: This study explores how character race may influence HIV/STI risk perceptions of young men who have sex with men (MSM), using a social experimental study design.

Methods: A sample of 134 MSM were recruited to participate in a 30-45 minute, in-person laboratory study at three Midwest universities. Data were collected from July 2015 to June 2016. Read More

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http://dx.doi.org/10.1097/QAI.0000000000002004DOI Listing
February 2019

Religiosity, social support and ethnic identity: Exploring "resilience resources" for African-American women experiencing HIV-related stigma.

J Acquir Immune Defic Syndr 2019 Feb 21. Epub 2019 Feb 21.

Department of Global Health Department of Psychiatry and Behavioral Sciences University of Washington Seattle, Washington.

Introduction: African-American women living with HIV report substantial HIV-related stigma and depression. Resilience resources are strength-based resources that may moderate the effects of HIV-related stigma on poor psychosocial outcomes such as depression.

Objective: To evaluate whether religiosity, social support and ethnic identity moderate the effects of HIV-related stigma on depression among African-American women living with HIV. Read More

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http://dx.doi.org/10.1097/QAI.0000000000002006DOI Listing
February 2019
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Markers of Bone Mineral Metabolism and Cardiac Structure and Function in Perinatally HIV-Infected and HIV-Exposed but Uninfected Children and Adolescents.

J Acquir Immune Defic Syndr 2019 Feb 21. Epub 2019 Feb 21.

. Department of Pediatrics, School of Medicine, Wayne State University, Detroit, MI.

Background: Disordered bone mineral metabolism and low vitamin D concentrations are associated with cardiovascular abnormalities; few studies have evaluated this relationship in HIV-infected youth.

Setting: Adolescent Master Protocol (AMP) is a Pediatric HIV/AIDS Cohort Study (PHACS) network study conducted across 14 United States sites.

Methods: Among perinatally HIV-infected (PHIV) and HIV-exposed uninfected (PHEU) youth enrolled in AMP, we evaluated associations of vitamin D (measured as 25-hydroxyvitamin D [25OHD]), parathyroid hormone (PTH), calcium, phosphate, and fibroblast growth factor-23 (FGF-23) concentrations with echocardiographic measures of left ventricular (LV) structure, function and concentrations of NT-proBNP, a biomarker of cardiac damage. Read More

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http://dx.doi.org/10.1097/QAI.0000000000002007DOI Listing
February 2019