7,846 results match your criteria JAIDS: Journal of Acquired Immune Deficiency Syndromes[Journal]


Medical intensive care unit admission among patients with and without HIV, hepatitis C virus, and alcohol-related diagnoses in the United States: a national, retrospective cohort study, 1997-2014.

J Acquir Immune Defic Syndr 2018 Oct 29. Epub 2018 Oct 29.

Internal Medicine, Yale School of Medicine, New Haven, CT, USA.

Background: HIV, hepatitis C virus (HCV), and alcohol-related diagnoses (ARD) independently contribute increased risk for all-cause hospitalization. We sought to determine annual medical intensive care unit (MICU) admission rates and relative risk of MICU admission between 1997 and 2014 among people with and without HIV, HCV, and ARD, using data from the largest HIV and HCV care provider in the United States.

Setting: Veterans Health Administration. Read More

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October 2018
3 Reads
4.560 Impact Factor

Impact of antiretroviral drugs on fracture risk in HIV-infected individuals: A case-control study nested within the French Hospital Database on HIV (FHDH-ANRS CO4).

J Acquir Immune Defic Syndr 2018 Oct 29. Epub 2018 Oct 29.

APHP, Hôpital Pitié-Salpêtrière, Paris, France.

Background: HIV-infected patients have lower bone mineral density and a higher incidence of fractures than the general population of the same age and sex. To assess the impact of antiretroviral drugs (ARV) exposure on the risk of osteoporotic fractures, we conducted a nested case-control study.

Methods: Cases were individuals enrolled while ARV-naive, with a first prospectively recorded fracture between 2000 and 2010. Read More

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October 2018
4 Reads
4.560 Impact Factor

Impact of a youth-focused care model on retention and virologic suppression among young adults with HIV cared for in an adult HIV clinic.

J Acquir Immune Defic Syndr 2018 Oct 29. Epub 2018 Oct 29.

. Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, MD.

Background: Young adults with HIV (YAHIV) are less likely to be retained in care or achieve viral suppression when seen in adult clinics. We assessed outcomes of a youth focused care model versus standard of care within a large adult HIV clinic.

Setting: The Accessing Care Early (ACE) program for YAHIV is embedded within an adult clinic. Read More

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October 2018
2 Reads

Perceived versus calculated HIV risk: Implications for Pre-exposure prophylaxis uptake in a randomized trial of men who have sex with men.

J Acquir Immune Defic Syndr 2018 Oct 29. Epub 2018 Oct 29.

University of California, San Diego, La Jolla, CA.

Background: Inaccurate HIV risk perception by men who have sex with men (MSM) is a barrier to HIV prevention. Providing information about objective HIV risk could improve preexposure prophylaxis (PrEP) uptake.

Methods: PrEP Accessibility Research & Evaluation 2 (PrEPARE2) was a randomized controlled trial of MSM to determine if an objective risk score affects future PrEP uptake. Read More

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October 2018

The impact of home-based HIV testing services on progress towards the UNAIDS 90-90-90 targets in a hyperendemic area of South Africa.

J Acquir Immune Defic Syndr 2018 Oct 29. Epub 2018 Oct 29.

Centre for the AIDS Programme of Research in South Africa (CAPRISA), University of KwaZulu-Natal, Durban, South Africa.

Background: In several sub-groups of South Africa, the percentage of HIV-positive individuals aware of their status falls well below the UNAIDS 90% target. This study examined the impact that home-based HIV testing services (HBHTS) had on knowledge of status in a hyperendemic area of South Africa.

Methods: We analysed data from the second cross-sectional HIV Incidence Provincial Surveillance System survey (2015/2016), a representative sample (n=10236) of individuals aged 15-49 years. Read More

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October 2018

Prediction OF HIV Transmission Cluster Growth with Statewide Surveillance Data.

J Acquir Immune Defic Syndr 2018 Nov 5. Epub 2018 Nov 5.

Institute for Global Health and Infectious Diseases, University of North Carolina at Chapel Hill, Chapel Hill, 27599, USA.

Background: Prediction of HIV transmission cluster growth may help guide public health action. We developed a predictive model for cluster growth in North Carolina (NC) using routine HIV surveillance data.

Methods: We identified putative transmission clusters with ≥2 members via pairwise genetic distances ≤1. Read More

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November 2018
1 Read

Decreases in self-reported ART adherence predict HIV viremia among pregnant and postpartum South African women.

J Acquir Immune Defic Syndr 2018 Nov 5. Epub 2018 Nov 5.

Division of Epidemiology & Biostatistics and Centre for Infectious Disease Epidemiology & Research, School of Public Health & Family Medicine, University of Cape Town, South Africa.

Introduction: Routine HIV viral load (VL) monitoring is recommended for patients on antiretroviral therapy (ART) but frequent VL testing, required in pregnant and postpartum women, is often not feasible. Self-reported adherence can be valuable, but little is known about its longitudinal characteristics.

Methods: We followed women living with HIV from ART initiation in pregnancy through 18 months postpartum in Cape Town, South Africa, with repeated measurement of VL and self-reported adherence using a three-item scale. Read More

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November 2018
4 Reads

Body Mass Index and Cognitive Function among HIV-1 Infected Individuals in China, India and Nigeria.

J Acquir Immune Defic Syndr 2018 Nov 5. Epub 2018 Nov 5.

University of California San Diego, School of Medicine, San Diego, United States, CA 92103.

Background: Risk of cognitive impairment is increased among persons with high or low body mass index (BMI) in HIV- and HIV+ populations in resource-rich settings. We examined this association among HIV+ patients in three resource-limited settings.

Methods: This secondary analysis included data of 761 HIV+ volunteers pooled from 3 prospective cohort studies conducted in China (n=404; 53%), India (n=200; 26%) and Nigeria (n=157; 21%). Read More

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November 2018
2 Reads
4.556 Impact Factor

Laboratory-reflex cryptococcal antigen screening is associated with a survival benefit in Tanzania.

J Acquir Immune Defic Syndr 2018 Nov 5. Epub 2018 Nov 5.

Ifakara Health Institute, Ifakara, Tanzania.

Background: Cryptococcal antigen (CrAg) screening in persons with advanced HIV/AIDS is recommended to prevent death. Implementing CrAg screening only in outpatients may underestimate the true CrAg prevalence and decrease its potential impact. Our previous 12-month survival/retention in CrAg-positive persons not treated with fluconazole was 0%. Read More

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November 2018
6 Reads

Gut structural damage, an ongoing process in chronically untreated HIV infection.

J Acquir Immune Defic Syndr 2018 Nov 5. Epub 2018 Nov 5.

Case Western Reserve University, Cleveland, OH.

Objective: To investigate the longitudinal changes of gut structural damage in chronically untreated HIV infection.

Design: This is a 96-week prospective, single site, cohort study of antiretroviral therapy (ART)-naïve HIV-infected participants.

Methods: Intestinal fatty acid-binding proteins (I-FABP) was used as a surrogate marker of gut structural damage. Read More

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November 2018
5 Reads

S100a14 is Increased in Activated Nk Cells and Plasma of HIV-Exposed Seronegative People Who Inject Drugs and Promotes Monocyte-Nk crosstalk.

J Acquir Immune Defic Syndr 2018 Nov 5. Epub 2018 Nov 5.

HIV Immunopathogenesis Laboratory, The Wistar Institute, Philadelphia, PA.

Background: HIV-exposed sero-negative people who inject drugs (HESN-PWID) have been shown to have increased NK cell and myeloid activation when compared to control donors.

Methods: We investigated potential mechanisms maintaining NK activation by conducting quantitative proteome comparisons of NK cells from HESN-PWID subjects and control donors. Proteins upregulated in NK cells were measured in the plasma of HESN-PWID subjects by ELISA and further investigated for their ability to induce innate immune activation in vitro. Read More

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November 2018
1 Read

Comfort discussing HIV pre-exposure prophylaxis with patients among physicians in an urban emergency department.

J Acquir Immune Defic Syndr 2018 Nov 5. Epub 2018 Nov 5.

Division of Infectious Diseases, Washington University in St. Louis, St. Louis, Missouri.

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November 2018

Efficacy and safety of tenofovir disoproxil fumarate versus low-dose stavudine over 96 weeks: a multi-country randomised, non-inferiority trial.

J Acquir Immune Defic Syndr 2018 Nov 12. Epub 2018 Nov 12.

Chief Medical Officer, YRG Centre for AIDS Research & Education, Voluntary Health Services, Tidal Park Road, Taramani, Chennai 600113, India. Address: YRGCARE Medical Centre, VHS, Chennai, INDIA.

Background: Reducing doses of antiretroviral drugs, including stavudine (d4T), may lower toxicity, while preserving efficacy. There are substantial concerns about renal and bone toxicities of tenofovir disoproxil fumarate (TDF).

Setting: HIV-1-infected treatment-naive adults in India, South Africa and Uganda METHODS: A phase-4, 96-week, randomized, double-blind, non-inferiority trial compared d4T 20mg BD and TDF, taken in combination with lamivudine (3TC) and efavirenz (EFV). Read More

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November 2018
7 Reads

Better outcomes among HIV-infected Rwandan children 18-60 months following the implementation of "treat all".

J Acquir Immune Defic Syndr 2018 Nov 12. Epub 2018 Nov 12.

Rwanda Biomedical Center, Kigali, Rwanda.

Background: In 2012, Rwanda introduced a Treat All approach for HIV-infected children under age 5. We compared antiretroviral therapy (ART) initiation, outcomes, and retention, before and after this change.

Methods: We conducted a retrospective study of children enrolled into care between June 2009-December 2011 (Before Treat All cohort [BTA]) and between July 2012-April 2015 (Treat All cohort [TA]). Read More

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November 2018
2 Reads
4.560 Impact Factor

Interest of Youth Living with HIV in Long-Acting Antiretrovirals.

J Acquir Immune Defic Syndr 2018 Nov 8. Epub 2018 Nov 8.

Divisions of Adult & Pediatric Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Objectives: This study's primary objective was to characterize attitudes to long-acting antiretrovirals (LAARV), among youth aged 13 to 24 years living with perinatally- and non-perinatally-acquired HIV (PHIV and NPHIV, respectively). Secondary objectives included: assessing whether those with detectable HIV RNA PCR viral load had higher enthusiasm for LAARV compared to those with suppressed viral load, and examining characteristics associated with LAARV enthusiasm.

Methods: A cross-sectional survey of 303 Youth Living with HIV (YHIV) followed at four pediatric/adolescent HIV clinics in the USA was performed to determine interest in LAARV, using a modified survey instrument previously used in adults. Read More

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November 2018
3 Reads

Increased neutrophil surface PD-L1 expression in tobacco smokers: consequences for anti-PD-1 treatment.

J Acquir Immune Defic Syndr 2018 Oct 26. Epub 2018 Oct 26.

Institute of Human Genetics, UMR9002, CNRS-Montpellier University, Montpellier, France.

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October 2018
4 Reads

PD-1 expression in HIV-specific CD8+ T-cells prior to antiretroviral therapy is associated with HIV persistence.

J Acquir Immune Defic Syndr 2018 Oct 26. Epub 2018 Oct 26.

CONICET-Universidad de Buenos Aires. Instituto de Investigaciones Biomédicas en Retrovirus y Sida (INBIRS). Buenos Aires, Argentina.

Background: The persistence of latently infected T-cells remains the principal barrier to HIV cure. Understanding how the early immune responses shape persistence of HIV on antiretroviral therapy (ART) will be fundamental for potential eradication. Here, we aimed to determine the relationship between CD8 T-cell function and phenotype prior to therapy and HIV persistence on-ART. Read More

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October 2018
4 Reads

Rate of Nicotine Metabolism and Tobacco Use among Persons with HIV: Implications for Treatment and Research.

J Acquir Immune Defic Syndr 2018 Oct 26. Epub 2018 Oct 26.

Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, 3535 Market Street, Suite 4100, Philadelphia, PA 19104, USA.

Background: The nicotine metabolite ratio (NMR) is a biomarker that represents individual variation in the speed that nicotine is metabolized. The rate of nicotine metabolism alters smoking behavior (e.g. Read More

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October 2018
4 Reads

The role of socio-behavioral factors in sub-protective tenofovir diphosphate (TFV-DP) levels among YMSM enrolled in two PrEP trials.

J Acquir Immune Defic Syndr 2018 Oct 26. Epub 2018 Oct 26.

Department of Psychiatry Stroger Hospital of Cook County 1900 W Polk Street, #854 Chicago, IL 60612

Background: Young men who have sex with men (YMSM) experience disparities in HIV acquisition more than any other group. Daily oral pre-exposure prophylaxis (PrEP) with tenofovir/embricitabine (TDF/FTC) has been shown to effectively prevent HIV transmission in YMSM; however, recent studies suggest that young Black men who have sex with men (YBMSM) experience sub-protective levels of tenofovir diphosphate (TFV-DP) more frequently than other groups.

Setting: Combined data from Adolescent Medicine Trials Network for HIV/AIDS Interventions (ATN) 110/113, two open label PrEP studies that provided PrEP and evidence-based behavioral interventions to young MSM (YMSM) age 15 to 22 years old. Read More

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October 2018
2 Reads

HIV-Related Stigma Affects Cognition in Older Men Living with HIV.

J Acquir Immune Defic Syndr 2018 Nov 13. Epub 2018 Nov 13.

Dept. of Neurology & Neurosurgery, Montreal Neurological Institute, McGill University 3801 University St., Montreal QC Canada H3A 2B4.

Background: Stigma remains a reality for many people living with HIV. Stigma bears on mental health, but we hypothesized that it might also affect cognition, in turn affecting function.

Methods: We estimated the impact of HIV-related stigma on brain health and everyday functioning among 512 older Caucasian men living with HIV in Canada, using the International Classification of Functioning, Disability and Health as a comprehensive framework to integrate biopsychosocial perspectives. Read More

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November 2018
4 Reads

Monocyte-to-lymphocyte ratio is associated with tuberculosis disease and declines with anti-TB treatment in HIV-infected children.

J Acquir Immune Defic Syndr 2018 Oct 26. Epub 2018 Oct 26.

Department of Pediatrics, Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, GA, USA.

Background: The blood monocyte-to-lymphocyte ratio (MLR) is associated with active tuberculosis (TB) in adults, but has not been evaluated as a TB diagnostic biomarker in HIV-infected children in whom respiratory sampling is difficult.

Setting: In a cohort of HIV-infected hospitalized Kenyan children initiating antiretroviral therapy, absolute monocyte and lymphocyte counts were determined at enrollment and 4, 12, and 24 weeks thereafter.

Methods: Children were classified as confirmed, unconfirmed, or unlikely pulmonary TB. Read More

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October 2018
4 Reads

Effectiveness of a lay counsellor-led combination intervention for retention of mothers and infants in HIV care: A randomized trial in Kenya.

J Acquir Immune Defic Syndr 2018 Nov 5. Epub 2018 Nov 5.

ICAP at Mailman School of Public Health, Columbia University, New York, NY, USA College of Physicians & Surgeons, Columbia University, New York, NY, United States

Background: Retention of mothers and infants across the prevention of mother-to-child HIV transmission continuum remains challenging. We assessed the effectiveness of a lay worker administered combination intervention compared with the standard of care (SOC) on mother-infant attrition.

Methods: HIV-positive pregnant women starting antenatal care at 10 facilities in western Kenya were randomized using simple randomization to receive individualized health education, retention/adherence support, appointment reminders and missed visit tracking versus routine care per guidelines. Read More

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November 2018
6 Reads

Reflexive laboratory-based cryptococcal antigen screening and preemptive fluconazole therapy for cryptococcal antigenemia in HIV-infected individuals with CD4 <100 cells/µL: a stepped-wedge, cluster-randomized trial.

J Acquir Immune Defic Syndr 2018 Nov 5. Epub 2018 Nov 5.

Department of Medicine, Division of Infectious Diseases and International Medicine, University of Minnesota, Minneapolis, MN, USA.

Background: HIV-infected persons with cryptococcal antigenemia (CrAg) are at high risk for meningitis or death. We evaluated the effect of CrAg screening and pre-emptive fluconazole therapy, as an adjunct to antiretroviral therapy (ART), on six-month survival among persons with advanced HIV disease.

Methods: We enrolled HIV-infected, ART-naïve eligible participants with <100 CD4 cells/µL, in a stepped-wedge, cluster-randomized trial from July 2012 - December 2014 at 17 Ugandan clinics. Read More

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November 2018
5 Reads

Opioid Misuse among HIV-Positive Adults in Medical Care: Results from the Medical Monitoring Project, 2009 - 2014.

J Acquir Immune Defic Syndr 2018 Oct 23. Epub 2018 Oct 23.

Centers for Disease Control and Prevention, Division of HIV/AIDS Prevention.

Background: People living with HIV are prescribed opioids more often and at higher doses than people who do not have HIV, and disproportionately experience risk factors for substance use disorder, which suggests they could be at increased risk for the misuse of opioids. Researchers also suggest that opioid misuse negatively affects various HIV clinical outcomes, increasing the risk of transmission to partners with an HIV-negative status.

Methods: We calculated weighted percentages and 95% confidence intervals to estimate substance use characteristics among a probability sample of 28,162 HIV-positive adults receiving medical care in the US who misused opioids (n=975). Read More

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October 2018
4 Reads

Pregnancy and Infant Outcomes Among Women Using the Dapivirine Vaginal Ring in Early Pregnancy.

J Acquir Immune Defic Syndr 2018 Dec;79(5):566-572

Global Health, University of Washington, Seattle, WA.

Background: Monthly use of the dapivirine vaginal ring has been shown to be safe and effective for HIV-1 prevention in nonpregnant reproductive-aged women. The impact of dapivirine on pregnancy outcomes and infant is not known. We compared pregnancy incidence and outcomes by study arm among HIV-1-uninfected women who became pregnant while participating in MTN-020/ASPIRE. Read More

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December 2018
5 Reads

HIV-Related Stigma, Motivation to Adhere to Antiretroviral Therapy, and Medication Adherence among HIV-Positive Methadone-Maintained Patients.

J Acquir Immune Defic Syndr 2018 Oct 23. Epub 2018 Oct 23.

Department of Allied Health Sciences, University of Connecticut, Storrs, CT, USA.

Background: Opioid agonist therapies with methadone are associated with higher levels of adherence to antiretroviral therapy (ART), yet no studies have explored factors associated with optimal ART levels in HIV-positive patients on methadone maintenance treatment (MMT), including explanatory pathways using mediation analysis.

Setting: Participants included 121 HIV-positive, methadone-maintained patients who reported HIV-risk behaviors and were taking ART.

Methods: Participants were assessed using an audio-computer assisted self-interview (ACASI). Read More

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October 2018
1 Read
4.556 Impact Factor

Effect of TB/HIV Integration on TB and HIV Indicators in Rural Ugandan Health Facilities.

J Acquir Immune Defic Syndr 2018 Dec;79(5):605-611

Infectious Diseases Institute, College of Health Sciences, Makerere University, Kampala, Uganda.

Background: The World Health Organization recommends integrating services for patients coinfected with tuberculosis (TB) and HIV. We assessed the effect of TB/HIV integration on antiretroviral therapy (ART) initiation and TB treatment outcomes among TB/HIV-coinfected patients using data collected from 14 rural health facilities during 2 previous TB and HIV quality of care studies.

Methods: A facility was considered to have integrated TB/HIV services if patients with TB/HIV had combined treatment for both illnesses by 1 provider or care team at 1 treatment location. Read More

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December 2018
3 Reads

Muscle Strength and Aerobic Capacity in HIV-Infected Patients: A Systematic Review and Meta-Analysis.

J Acquir Immune Defic Syndr 2018 Dec;79(4):491-500

Programa de Pós-graduação em Medicina e Saúde da Universidade Federal da Bahia (UFBA), Salvador, Bahia, Brazil.

Background: Physical impairment is highly prevalent in HIV-infected patients. We conducted a systematic review of published studies that included studies comparing muscle function in HIV-infected patients to matched healthy controls, and studies comparing aerobic capacity in HIV-infected patients with that observed in matched healthy controls.

Design: Systematic review and meta-analysis. Read More

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December 2018
3 Reads

Brief Report: HIV Pre-exposure Prophylaxis Engagement Among Adolescent Men Who Have Sex With Men: The Role of Parent-Adolescent Communication About Sex.

J Acquir Immune Defic Syndr 2018 Dec;79(4):453-457

Department of Prevention and Community Health, Milken Institute School of Public Health, George Washington University, Washington, DC.

Background: Adolescent men who have sex with men (AMSM) are severely affected by the HIV epidemic in the United States. Pre-exposure prophylaxis (PrEP) has proven extremely effective in preventing new HIV infections among adult men who have sex with men, but no research has examined PrEP awareness among AMSM. Furthermore, initial research investigating PrEP adherence among AMSM has found low adherence to the medication regimen. Read More

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December 2018

Patient Self-Reported Adherence to Ritonavir-Boosted Darunavir Combined With Either Raltegravir or Tenofovir Disoproxil Fumarate/Emtricitabine in the NEAT001/ANRS143 Trial.

J Acquir Immune Defic Syndr 2018 Dec;79(4):481-490

Infectious and Tropical Diseases Department, INSERM CIC 1413, CHU, Nantes, France.

Background: The NEAT001/ANRS143 trial demonstrated noninferiority of ritonavir-boosted darunavir combined with either raltegravir (RAL + DRV/r) or tenofovir disoproxil fumarate/emtricitabine (TDF/FTC + DRV/r) in HIV-positive, antiretroviral-naive adults. In post hoc analyses, however, RAL + DRV/r showed inferiority in patients with baseline CD4 <200/mm and HIV-1 RNA ≥100,000 copies per milliliter. This preplanned ancillary study was conducted to assess whether differences in adherence might explain efficacy results. Read More

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December 2018
8 Reads

Individual and Network Factors Associated with Racial Disparities in HIV Among Young Men who have sex with Men: Results from the Radar Cohort Study.

J Acquir Immune Defic Syndr 2018 Oct 25. Epub 2018 Oct 25.

Department of Medical Social Sciences & Institute for Sexual and Gender Minority Health and Wellbeing, Northwestern University Feinberg School of Medicine.

Background: Individual sexual risk behaviors have failed to explain the observed racial disparity in HIV acquisition. To increase understanding of potential drivers in disparities, we assessed differences across individual, network, and social determinants.

Methods: Data come from RADAR (N=1015), a longitudinal cohort study of multilevel HIV-risk factors among young men who have sex with men (YMSM) aged 16-29 in Chicago. Read More

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October 2018
2 Reads

Inflammation Relates to Poorer Complex Motor Performance among Adults Living with HIV on Suppressive Antiretroviral Therapy.

J Acquir Immune Defic Syndr 2018 Oct 25. Epub 2018 Oct 25.

Department of Psychiatry, University of California San Diego.

Background: Inflammatory processes have been suggested to underlie early neurologic abnormalities among persons living with HIV (HIV-positive), such as deficits in complex motor function, that are purported to remit with effective antiretroviral treatment (ART). We hypothesized HIV will have negative direct and indirect effects via inflammation on complex motor performance.

Methods: The sample consisted of 90 ART-treated virally suppressed HIV-positive and 94 HIV-negative adults, ages 36 to 65 years, with balanced recruiting in each age decade (36-45, 46-55, 56-65). Read More

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October 2018
4 Reads

Brief Report: Age-Disparate Relationships and HIV Prevalence Among Never Married Women in Rakai, Uganda.

J Acquir Immune Defic Syndr 2018 Dec;79(4):430-434

Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD.

Background: Age-disparate relationships are associated with increased HIV prevalence. We determined whether the frequency of age-disparate relationships in never married women changed over time and whether they are associated with HIV prevalence in Rakai, Uganda.

Methods: A total of 10,061 never married women, aged 15-49 years, in the Rakai Community Cohort Study provided information on the age of their male sexual partners from 1997 to 2013. Read More

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December 2018
5 Reads

Response to: Cardiovascular Risk Profile of Transgender Women with HIV.

J Acquir Immune Defic Syndr 2018 Oct 10. Epub 2018 Oct 10.

Callen-Lorde Community Health Center, New York, NY.

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October 2018

Sexual Risk Compensation in a Pre-exposure Prophylaxis Demonstration Study among Individuals at Risk for HIV.

J Acquir Immune Defic Syndr 2018 Oct 10. Epub 2018 Oct 10.

University of California, San Diego.

Background: A public health concern regarding HIV pre-exposure prophylaxis (PrEP) is sexual risk compensation (i.e., increased unsafe sex among PrEP users that may undermine prevention efforts). Read More

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October 2018

Third-line antiretroviral therapy programme in the South African public sector: cohort description and virological outcomes.

J Acquir Immune Defic Syndr 2018 Oct 10. Epub 2018 Oct 10.

University of Witwatersrand, Faculty of Health Sciences, South Africa.

Background: WHO recommends that antiretroviral therapy (ART) programmes in resource-limited settings develop third-line ART policies. South Africa developed a national third-line ART programme for patients who have failed both first-line non-nucleoside reverse transcriptase inhibitor-based ART and second-line protease inhibitor-based (PI) ART. We report on this programme. Read More

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October 2018
3 Reads

Analyses of Mitochondrial DNA and Immune Phenotyping Suggest Accelerated T-Cell Turnover in Treated HIV.

J Acquir Immune Defic Syndr 2018 Nov;79(3):399-406

Department of Medicine, University of California San Diego, CA.

Background: HIV infection is associated with premature aging, and mitochondrial integrity is compromised during the aging process. Because mitochondrial toxicity is a consequence of antiretroviral therapies (ARTs), we hypothesized HIV and long-term ART would correlate with immunosenescence and mitochondrial DNA (mtDNA) pathology.

Setting: Thirteen older HIV-infected individuals (aged >40 years) with virologic suppression (stratified by duration of ART) were compared with 10 uninfected controls well-matched for age. Read More

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November 2018
2 Reads

Opioid Agonist Treatment and Improved Outcomes at Each Stage of the HIV Treatment Cascade in People Who Inject Drugs in Ukraine.

J Acquir Immune Defic Syndr 2018 Nov;79(3):288-295

Division of Epidemiology of Microbial Diseases, Yale University School of Public Health, New Haven, CT.

Background: The HIV treatment cascade is a crucial tool to guide HIV prevention and treatment strategies. The extent to which opioid agonist treatments (OATs) such as methadone and buprenorphine influence this cascade was examined in a nationwide study of people who inject drugs (PWID) in Ukraine.

Setting: Cross-sectional stratified survey of PWID followed by HIV and hepatitis C virus testing in 5 Ukrainian cities. Read More

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November 2018
5 Reads

Predictors of antiretroviral adherence self-efficacy among people living with HIV/AIDS in a Canadian setting.

J Acquir Immune Defic Syndr 2018 Oct 5. Epub 2018 Oct 5.

British Columbia Centre for Substance Use 400-1045 Howe Street, Vancouver, BC, CANADA, V6Z 2A9.

Background: Sub-optimal adherence to antiretroviral therapy among people living with HIV/AIDS (PLWHA) who use illicit drugs remains an ongoing health concern. Although health outcomes associated with adherence self-efficacy have been well-documented, there is dearth research exploring the predictors of this construct. This study sought to identify possible determinants of adherence self-efficacy among a cohort of PLWHA who use illicit drugs. Read More

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October 2018
1 Read

The Association of Fibroblast Growth Factor-23 (FGF-23) with Incident Frailty in HIV-Infected and -Uninfected Individuals.

J Acquir Immune Defic Syndr 2018 Oct 1. Epub 2018 Oct 1.

Kidney Health Research Collaborative, University of California, San Francisco and San Francisco VA Medical Center.

Background: In the Multicenter AIDS Cohort Study, we examined whether fibroblast growth factor-23 (FGF-23), a bone-derived phosphaturic hormone involved in bone metabolism, is associated with incident frailty. Further, we examined whether this association differs by HIV serostatus and race.

Methods: Of 715 men assessed for frailty and selected for FGF-23 measurements using stored blood samples (2007-2011), 512 men were non-frail at/prior to the baseline visit. Read More

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October 2018
2 Reads

Impact of an HIV Care Coordination Program on Durable Viral Suppression.

J Acquir Immune Defic Syndr 2018 Oct 1. Epub 2018 Oct 1.

Institute for Implementation Science in Population Health (ISPH), City University of New York (CUNY).

Background: To assess long-term effectiveness of an intensive and comprehensive Ryan White Part A-funded HIV Care Coordination Program (CCP) recruiting people living with HIV (PLWH) with a history of suboptimal HIV care outcomes.

Methods: We merged programmatic data on CCP clients with surveillance data on all adults diagnosed with HIV. Using propensity score matching, we identified a contemporaneous, non-CCP exposed comparison group. Read More

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October 2018
1 Read

Aging of the HIV Population in Australia: A Modeling Study.

J Acquir Immune Defic Syndr 2018 Dec;79(5):e115-e116

The Kirby Institute, University of New South Wales, Sydney, New South Wales, Australia.

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December 2018
5 Reads

The Association of Unmet Needs with Subsequent Retention in Care and HIV Suppression Among Hospitalized Patients with HIV Who Are Out of Care.

J Acquir Immune Defic Syndr 2018 Sep 21. Epub 2018 Sep 21.

Department of Medicine, Section of Infectious Diseases, Baylor College of Medicine, Houston, Texas.

Background: Unmet needs among hospitalized patients with HIV may prevent engagement in HIV care leading to worse clinical outcomes. Our aim was to examine the role of unmet subsistence needs (e.g. Read More

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September 2018
1 Read

Quantitative assessment of brief messages about HIV pre-exposure prophylaxis among HIV-infected and HIV-uninfected black/African American and Hispanic/Latino MSM.

J Acquir Immune Defic Syndr 2018 Sep 21. Epub 2018 Sep 21.

US Centers for Disease Control and Prevention, Division of HIV/AIDS Prevention, Atlanta, GA.

Background: HIV pre-exposure prophylaxis (PrEP) is efficacious, however many MSM (especially racial/ethnic minorities) are still unaware of and under-utilize it.

Methods: The 2014 Messages4Men Study focuses on black and Hispanic/Latino MSM in Chicago, Fort Lauderdale, and Kansas City (n=937). Brief (2-3 sentence) messages were tested: a PrEP message tailored for HIV-uninfected MSM (n=607) and a PrEP message tailored for HIV-infected MSM (n=330). Read More

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September 2018
4 Reads
4.560 Impact Factor

Natural History of Cervical Intraepithelial Neoplasia-2 in HIV-Positive Women of Reproductive Age.

J Acquir Immune Defic Syndr 2018 Dec;79(5):573-579

Department of Medicine, Georgetown University, Washington, DC.

Objective: To evaluate the natural history of treated and untreated cervical intraepithelial neoplasia-2 (CIN2) among HIV-positive women.

Methods: Participants were women enrolled in the Women's Interagency HIV Study between 1994 and 2013. One hundred four HIV-positive women diagnosed with CIN2 before age 46 were selected, contributing 2076 visits over a median of 10 years (interquartile range 5-16). Read More

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December 2018
1 Read

Stimulant Use and Viral Suppression In the Era of Universal Antiretroviral Therapy.

J Acquir Immune Defic Syndr 2018 Sep 21. Epub 2018 Sep 21.

University of California, San Francisco School of Medicine.

Background: HIV-positive persons who use stimulants such as methamphetamine experience difficulties navigating the HIV care continuum that undermine the benefits of anti-retroviral therapy (ART). However, few studies have examined the association of stimulant use with viral suppression in the era of universal ART.

Setting: Zuckerberg San Francisco General Hospital METHODS:: HIV-positive persons participating in a clinical cohort study and taking ART completed assessments every 4-6 months. Read More

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September 2018
2 Reads