6,740 results match your criteria JAIDS: Journal of Acquired Immune Deficiency Syndromes[Journal]


Human immunodeficiency virus, elevated transaminases, fatty liver: the perfect storm?

J Acquir Immune Defic Syndr 2019 Feb 7. Epub 2019 Feb 7.

Royal Victoria Hospital, McGill University Health Centre, Montreal, QC, Canada.

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http://dx.doi.org/10.1097/QAI.0000000000001984DOI Listing
February 2019

How language hides violence against girls.

J Acquir Immune Defic Syndr 2019 Feb 7. Epub 2019 Feb 7.

Kings College London.

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http://dx.doi.org/10.1097/QAI.0000000000001985DOI Listing
February 2019

High plasma soluble CD163 during infancy is a marker for neurocognitive outcomes in early treated HIV-infected children.

J Acquir Immune Defic Syndr 2019 Feb 7. Epub 2019 Feb 7.

Department of Global Health, University of Washington, Seattle, WA, USA.

Background: Monocyte activation may contribute to neuronal injury in aviremic HIV-infected adults; data are lacking in children. We examined the relation between monocyte activation markers and early and long-term neurodevelopmental outcomes in early-treated HIV-infected children.

Setting: Prospective study of infant and child neurodevelopmental outcomes nested within a randomized clinical trial (NCT00428116) and extended cohort study in Kenya. Read More

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http://dx.doi.org/10.1097/QAI.0000000000001979DOI Listing
February 2019
2 Reads

Changes in behavior following PrEP initiation among Australian gay and bisexual men.

J Acquir Immune Defic Syndr 2019 Feb 7. Epub 2019 Feb 7.

The Kirby Institute, UNSW Sydney, NSW, Australia.

Introduction: HIV pre-exposure prophylaxis (PrEP) has been increasingly adopted by gay and bisexual men (GBM). Little is known about whether individual GBM change their sexual behavior following PrEP initiation.

Methods: Following Lives Undergoing Change (Flux) is a national, online, prospective observational study among Australian GBM. Read More

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http://dx.doi.org/10.1097/QAI.0000000000001976DOI Listing
February 2019

Onward transmission of multiple HIV-1 unique recombinant forms among men who have sex with men in Beijing, China.

J Acquir Immune Defic Syndr 2019 Feb 7. Epub 2019 Feb 7.

Department of AIDS Research, State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China.

Background: Unique recombinant forms (URFs) were generated in dually-infected or multiply-infected individuals, and some of URFs can be transmitted to many people resulting in the emergence of circulating recombinant forms (CRFs). We examined whether there was evidence for onward transmission of multiple URFs among men who have sex with men (MSM) in Beijing.

Methods: A total of 146 MSM subjects with acute/early HIV-1 infection were recruited from the Beijing PRIMO clinical cohort between September 2010 and July 2012. Read More

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http://dx.doi.org/10.1097/QAI.0000000000001983DOI Listing
February 2019

Insomnia as an Independent Predictor of Incident Cardiovascular Disease in HIV: Data from the Veterans Aging Cohort Study.

J Acquir Immune Defic Syndr 2019 Feb 7. Epub 2019 Feb 7.

Department of Psychology, Indiana University-Purdue University Indianapolis (IUPUI), Indianapolis, Indiana.

Background: Insomnia is associated with increased cardiovascular disease (CVD) risk in the general population and is highly prevalent in people with HIV. The CVD risk conferred by insomnia in the HIV population is unknown.

Methods: Using the Veterans Aging Cohort Study-Survey Cohort, insomnia symptoms were measured and dummy coded with the item, "Difficulty falling or staying asleep?" (5-point scale from no difficulty to bothers a lot). Read More

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http://dx.doi.org/10.1097/QAI.0000000000001981DOI Listing
February 2019

Title: How can programmes better support female sex workers to avoid HIV infection in Zimbabwe? A prevention cascade analysis.

J Acquir Immune Defic Syndr 2019 Feb 7. Epub 2019 Feb 7.

Department of Social and Environmental Health Research, Public Health and Policy, London School of Hygiene and Tropical Medicine, London, UK.

Background: 'HIV prevention cascades' have been proposed to support programmes by identifying gaps in demand for, access to and capability to adhere to HIV prevention tools, but there are few empirical examples to guide development. We apply a prevention cascade framework to examine prevention coverage and factors associated with condoms and/or PrEP adherence among female sex workers (FSW).

Setting: Seven sites across Zimbabwe. Read More

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http://dx.doi.org/10.1097/QAI.0000000000001980DOI Listing
February 2019

Heterogeneous HIV-1 reactivation patterns of disulfiram and combined disulfiram+romidepsin treatments.

J Acquir Immune Defic Syndr 2019 Feb 7. Epub 2019 Feb 7.

Service of Molecular Virology, Institut de Biologie et de Médecine Moléculaires (IBMM), Université Libre de Bruxelles (ULB), Gosselies, Belgium.

Objectives: Few single latency-reversing agents (LRAs) have been tested in vivo and only some of them have demonstrated an effect, albeit weak, on the decrease of latent reservoir. Therefore, other LRAs and combinations of LRAs need to be assessed. Here, we evaluated the potential of combined treatments of therapeutically promising LRAs, disulfiram and romidepsin. Read More

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http://dx.doi.org/10.1097/QAI.0000000000001958DOI Listing
February 2019

Clinical and Sociobehavioral Prediction Model of 30-Day Hospital Readmissions Among People With HIV and Substance Use Disorder: Beyond Electronic Health Record Data.

J Acquir Immune Defic Syndr 2019 Mar;80(3):330-341

Division of General Internal Medicine, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX.

Background: Under the Affordable Care Act, hospitals receive reduced reimbursements for excessive 30-day readmissions. However, the Centers for Medicare and Medicaid Services does not consider social and behavioral variables in expected readmission rate calculations, which may unfairly penalize systems caring for socially disadvantaged patients, including patients with HIV.

Setting: Randomized controlled trial of patient navigation with or without financial incentives in HIV-positive substance users recruited from the inpatient setting at 11 US hospitals. Read More

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http://Insights.ovid.com/crossref?an=00126334-201903010-0001
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http://dx.doi.org/10.1097/QAI.0000000000001925DOI Listing
March 2019
2 Reads

Reply.

J Acquir Immune Defic Syndr 2019 Mar;80(3):e84-e85

Massachusetts General Hospital and Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1097/QAI.0000000000001944DOI Listing

Reply.

J Acquir Immune Defic Syndr 2019 Mar;80(3):e84

Callen-Lorde Community Health Center, New York, NY.

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http://dx.doi.org/10.1097/QAI.0000000000001884DOI Listing

Characterizing Sociostructural Associations With New HIV Diagnoses Among Female Sex Workers in Cameroon.

J Acquir Immune Defic Syndr 2019 Mar;80(3):e64-e73

Department of Epidemiology, Johns Hopkins School of Public Health, Baltimore, MD.

Background: Female sex workers (FSW) are disproportionately affected by HIV in Cameroon, with an estimated 23.6% HIV prevalence. Given the unavailability of HIV incidence data, to better understand associations with acquiring HIV we assessed the prevalence and associations with new HIV diagnoses among FSW in Cameroon. Read More

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http://dx.doi.org/10.1097/QAI.0000000000001920DOI Listing
March 2019
7 Reads

Cocaine Use and Pre-Exposure Prophylaxis: Adherence, Care Engagement, and Kidney Function.

J Acquir Immune Defic Syndr 2019 Jan 25. Epub 2019 Jan 25.

Department of Public Health Sciences, University of Miami, FL.

Background: Concomitant use of cocaine and HIV pre-exposure prophylaxis (PrEP) raises important clinical questions around adherence, retention in care, and renal toxicity.

Methods: We assessed the associations of confirmed cocaine use with PrEP adherence (both ascertained via objective measures), care engagement, and renal function in the iPrEx open label extension. Cocaine use was measured in scalp hair samples and categorized as: light (500-3,000 pg/mg) and moderate to heavy (>3,000 pg/mg). Read More

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http://dx.doi.org/10.1097/QAI.0000000000001972DOI Listing
January 2019
2 Reads

Syphilis co-infection is not associated with an increased risk of virologic failure among HIV-positive men who have sex with men on antiretroviral therapy.

J Acquir Immune Defic Syndr 2019 Jan 25. Epub 2019 Jan 25.

St. Michael's Hospital.

Background: Incidence of syphilis continues to rise among HIV-positive men who have sex with men (MSM) in Ontario. Our objective was to determine the effect of acute syphilis on virologic failure (VF) among virally suppressed HIV-positive MSM taking antiretroviral therapy (ART) and determine if the relationship is confounded by drug use.

Setting: The OHTN Cohort Study is a voluntary cohort of people receiving HIV care in Ontario. Read More

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http://dx.doi.org/10.1097/QAI.0000000000001962DOI Listing
January 2019

Female Genital Schistosomiasis and HIV: Research urgently needed to improve understanding of the health impacts of this important co-infection.

J Acquir Immune Defic Syndr 2019 Jan 25. Epub 2019 Jan 25.

Centre International de Recherches, d'Enseignements et de Soins en milieu tropical (CIRES), Akonolinga, Cameroon.

Evidence suggests that there are important interactions between HIV and Female Genital Schistosomiasis (FGS) that may have significant effects on individual and population health. However, the exact way they interact and the health impacts of the interactions are not well understood. In this paper we discuss what is known about the interactions between FGS and HIV, and the potential impact of the interactions. Read More

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http://dx.doi.org/10.1097/QAI.0000000000001957DOI Listing
January 2019
2 Reads

Results of a couples-based randomized controlled trial aimed to increase testing for HIV.

J Acquir Immune Defic Syndr 2019 Jan 30. Epub 2019 Jan 30.

Human Social Development, Human Sciences Research Council, Durban, South Africa.

Background: Although couples-based HIV testing and counseling (CHTC) is effective for facilitating mutual disclosure and linkage to HIV care, uptake remains low. Using a randomized controlled design, we tested the efficacy of a behavioral couples-based intervention aimed to increase CHTC.

Setting: The Vulindlela district of KwaZulu-Natal, South Africa. Read More

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http://dx.doi.org/10.1097/QAI.0000000000001948DOI Listing
January 2019
1 Read

Liver Enzyme Elevation in Pregnant Women Receiving Antiretroviral Therapy in the ANRS-French Perinatal Cohort.

J Acquir Immune Defic Syndr 2019 Jan 17. Epub 2019 Jan 17.

Professor, Department of Obstetrics and Gynecology, AP-HP, Hôpital Louis Mourier, Colombes, 92700 France, Department of Epidemiology. Centre de Recherche en Épidémiologie et Santé des Populations, Institut National de la Santé et dDe la Recherche Médicale (INSERM) U1018, Le Kremlin-Bicêtre 94270, France. Univ Diderot Paris 7, Paris, France.

Background: High rates of liver enzyme elevation (LEE) in women receiving antiretroviral treatment (ART) during pregnancy have been reported but causes remain unclear. We estimated the prevalence and risk factors of LEE in a national prospective multicenter cohort.

Methods: We studied 5748 pregnant women living with HIV enrolled in the French Perinatal Cohort 2005-2014, treated with ART, with no active hepatitis B or C co-infection. Read More

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http://dx.doi.org/10.1097/QAI.0000000000001963DOI Listing
January 2019
2 Reads

Pregnancy Incidence and Fertility Desires Among Couples by HIV Status in Rakai, Uganda.

J Acquir Immune Defic Syndr 2019 Jan 17. Epub 2019 Jan 17.

Makerere University, School of Public Health, Kampala, Uganda.

Background: The desire for more children and pregnancy rates are influenced by many relationship dynamics and HIV sero-status of couples.

Setting: Rakai Community Cohort Study (RCCS) in Uganda METHODS:: Couple data were retrospectively linked from survey rounds between 2007-15 to assess drivers of fertility desire and pregnancy incidence by HIV status (M-F-; M+F+; M-F+; M+F-). Multivariable modified Poisson regression was used to estimate Prevalence Ratios (PR) of fertility desire, while multivariable Poisson regression was used to estimate incidence rate ratios (IRR) of pregnancy associated with couple characteristics. Read More

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http://dx.doi.org/10.1097/QAI.0000000000001951DOI Listing
January 2019
1 Read

Association Between Erectile Dysfunction and Carotid Subclinical Atherosclerosis in HIV-Infected Patients.

J Acquir Immune Defic Syndr 2018 Dec 4. Epub 2018 Dec 4.

Unidad de Enfermedades Infecciosas. Hospital General Universitario Reina Sofía y Universidad de Murcia.

Background: Erectile dysfunction (ED) is frecuent in HIV infected patients and it can be associated with atherosclerosis and cardiovascular events. So, the objetive was to evaluate whether the presence of moderate-severe ED erectile dysfunction (ED) was a marker of subclinical atherosclerosis (SCA) in HIV-infected patients.

Methods: A cross-sectional study was carried out in a cohort of HIV-infected patients. Read More

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http://dx.doi.org/10.1097/QAI.0000000000001932DOI Listing
December 2018
2 Reads

Validation of a Urine Tenofovir Immunoassay for Adherence Monitoring to PrEP and ART and Establishing the Cut-Off for a Point-of-Care Test.

J Acquir Immune Defic Syndr 2019 Jan 11. Epub 2019 Jan 11.

Departments of Global Health, Medicine and Epidemiology, University of Washington, Seattle, WA.

Background: Current pharmacologic adherence monitoring for antiretrovirals involves expensive, labor-intensive liquid-chromatography/tandem-mass-spectrometry (LC-MS/MS)-based methods. Antibody-based assays can monitor and support adherence in real-time. We developed a tenofovir (TFV)-based immunoassay and further validated it in a directly-observed-therapy (DOT) study. Read More

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http://dx.doi.org/10.1097/QAI.0000000000001971DOI Listing
January 2019

Metabolic Syndrome and Neurocognitive Deficits in HIV infection.

J Acquir Immune Defic Syndr 2019 Jan 9. Epub 2019 Jan 9.

Department of Psychiatry, University of California San Diego VA San Diego Healthcare System.

Background: The adverse consequences of HIV and related comorbidities on the central nervous system remain prevalent in the era of combination antiretroviral therapy. Metabolic syndrome (MetS) is a common comorbidity in HIV and has been linked to increased neurocognitive impairment in the general population. We investigated the association between MetS and neurocognition among persons living with HIV (PLHIV). Read More

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http://dx.doi.org/10.1097/QAI.0000000000001964DOI Listing
January 2019
4 Reads

Potential Relationship between HIV Criminalization and Structural Stigma Related to Sexual Orientation in the U.S.

J Acquir Immune Defic Syndr 2019 Jan 9. Epub 2019 Jan 9.

Department of Epidemiology & Biostatistics, Drexel University Dornsife School of Public Health, Philadelphia, PA.

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http://dx.doi.org/10.1097/QAI.0000000000001961DOI Listing
January 2019

Risk Factors for Low CD4+ Count Recovery Despite Viral Suppression among Participants Initiating Antiretroviral Treatment with CD4+ Counts > 500 cells/mm3: Findings from the Strategic Timing of AntiRetroviral Treatment (START) Trial.

J Acquir Immune Defic Syndr 2019 Jan 9. Epub 2019 Jan 9.

University of Minnesota, Minneapolis, MN, USA.

Background: Low CD4+ recovery among HIV-positive individuals who achieve virologic suppression is common but has not been studied among individuals initiating treatment at CD4+ counts > 500 cells/mm.

Setting: United States, Africa, Asia, Europe & Israel, Australia, Latin America.

Methods: Among immediate-ART participants in the Strategic Timing of AntiRetroviral Therapy trial, low CD4+ recovery was defined as a CD4+ increase < 50 cells/mm from baseline after 8 months despite viral load ≤ 200 copies/mL. Read More

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http://dx.doi.org/10.1097/QAI.0000000000001967DOI Listing
January 2019
1 Read

Comparing sexual risk behavior in a high-risk group of men who have sex with men and transgender women in Lima, Peru.

J Acquir Immune Defic Syndr 2019 Jan 9. Epub 2019 Jan 9.

Department of Epidemiology, University of Washington, Seattle, WA.

Background: Transgender women (TW) and men who have sex with men (MSM) are often conflated in HIV research and prevention programs, despite clear differences that exist in culture and behavior.

Methods: We examined baseline data from a large treatment-as-prevention study among TW and MSM in Lima, Peru, to assess differences in risk behavior. Baseline assessment included HIV testing and a questionnaire including socio-demographics, sexual behavior, social venue attendance, and drug and alcohol use. Read More

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http://dx.doi.org/10.1097/QAI.0000000000001966DOI Listing
January 2019
1 Read

PrEP Eligibility among At-Risk Women in the Southern US: Associated Factors, Awareness and Acceptability.

J Acquir Immune Defic Syndr 2019 Jan 3. Epub 2019 Jan 3.

Emory University, Atlanta, GA.

Background: Among women in the US, non-Latina Black women in the South have disproportionately high rates of new HIV infections, but low use of pre-exposure prophylaxis (PrEP). Effective strategies to identify factors associated with PrEP eligibility could facilitate improved screening, offering, and uptake of PrEP among US women at risk for HIV.

Setting: and Methods: We applied 2014 CDC criteria for PrEP use to at-risk HIV-negative women enrolled in the Southern US sites (Atlanta, Chapel Hill, Birmingham/Jackson, Miami) of the Women's Interagency HIV Study from 2014-2015 to estimate PrEP eligibility and assess PrEP knowledge and acceptability. Read More

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http://Insights.ovid.com/crossref?an=00126334-900000000-9648
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http://dx.doi.org/10.1097/QAI.0000000000001950DOI Listing
January 2019
5 Reads

Chronic Distal Sensory Polyneuropathy is a Major Contributor to Balance Disturbances in Persons Living with HIV.

J Acquir Immune Defic Syndr 2019 Jan 3. Epub 2019 Jan 3.

VA San Diego Healthcare System, 3350 La Jolla Village Dr, San Diego, CA 92161, USA.

Background: Medical comorbidities accumulate in older persons living with HIV (PLWH), causing disability and reduced quality of life. Sensory neuropathy and polypharmacy may contribute to balance difficulties and falls. The contribution of neuropathy is understudied. Read More

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http://dx.doi.org/10.1097/QAI.0000000000001953DOI Listing
January 2019
1 Read

Cost-Effectiveness of Accelerated HIV Response Scenarios in Côte d'Ivoire.

J Acquir Immune Defic Syndr 2019 Aug 1. Epub 2019 Aug 1.

Centre de recherche du CHU de Québec - Université Laval, Québec, Canada.

Background: Despite Côte d'Ivoire epidemic being labelled as 'generalized', key populations (KP) are important to overall transmission. Using a dynamic model of HIV transmission, we previously estimated the impact of several treatment-as-prevention strategies that reached -or missed- the UNAIDS 90-90-90 targets in different populations groups, including KP and clients of female sex workers (CFSW). To inform program planning and resources allocation, we assessed the cost-effectiveness of these scenarios. Read More

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http://dx.doi.org/10.1097/QAI.0000000000001956DOI Listing

Does changing antiretroviral therapy in the first trimester of pregnancy for safety concerns have an impact on viral suppression ?

J Acquir Immune Defic Syndr 2019 Jan 8. Epub 2019 Jan 8.

CESP INSERM U1018, Le Kremlin-Bicêtre.

Objective: To determine whether changing antiretroviral therapy (ART) during pregnancy because of concern about fetal risks led to poorer virological outcomes.

Methods: All pregnancies in women with HIV1 infection enrolled in the national multicenter prospective French Perinatal cohort at 14 weeks' gestation or more were included between 01/2005 and 12/2015, if the mother was on ART at conception with a plasma viral load < 50 copies/ml. The reasons for a change in the ART were analyzed according to treatment guidelines at the time of the pregnancy, and defined as for safety concerns in the absence of reported maternal intolerance. Read More

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http://dx.doi.org/10.1097/QAI.0000000000001954DOI Listing
January 2019

STD Partner Services to Monitor and Promote HIV Pre-Exposure Prophylaxis Use Among Men Who Have Sex with Men.

J Acquir Immune Defic Syndr 2019 Jan 8. Epub 2019 Jan 8.

Department of Medicine , University of Washington, Seattle, WA, US.

Background: Men who have sex with men (MSM) with bacterial STDs are at elevated risk for HIV. We evaluated the integration of pre-exposure prophylaxis (PrEP) referrals into STD partner services (PS) for MSM.

Setting: King County, Washington METHODS:: Disease Intervention Specialists (DIS) in King County attempt to provide PS to all MSM with early syphilis and, as resources allow, MSM with gonorrhea or chlamydia. Read More

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http://dx.doi.org/10.1097/QAI.0000000000001952DOI Listing
January 2019
1 Read

Cryptococcosis-associated Immune Reconstitution Inflammatory Syndrome is associated with Dysregulation of IL-7/IL-7 Receptor Signaling Pathway in T-cells and Monocyte Activation.

J Acquir Immune Defic Syndr 2019 Jan 8. Epub 2019 Jan 8.

Africa Health Research Institute (AHRI), Durban, South Africa.

Background: Systemic levels of interleukin (IL)-7 at antiretroviral therapy (ART) initiation have previously been shown to be predictive of HIV-linked paradoxical cryptococcosis-associated immune reconstitution inflammatory syndrome (C-IRIS). We therefore explored IL-7/IL-7 receptor (IL-7/IL-7R) signaling pathway dysfunction, with related alterations in immune function, as a mechanism underlying C-IRIS.

Method: HIV-infected patients with cryptococcal meningitis (CM) who experienced C-IRIS (n=27) were compared to CD4+ T-cell count-matched counterparts without C-IRIS (n=27), following antifungal therapy and pre-ART initiation. Read More

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http://dx.doi.org/10.1097/QAI.0000000000001946DOI Listing
January 2019
3 Reads

HCV Screening and Treatment Uptake among Patients in HIV care During 2014-2015.

J Acquir Immune Defic Syndr 2019 Jan 8. Epub 2019 Jan 8.

Johns Hopkins University School of Medicine, Baltimore, MD.

Background: Despite the high prevalence of Hepatitis C Virus (HCV) among persons living with HIV (PWH), the prevalence of HCV screening, treatment, and sustained virologic response (SVR) is unknown. This study aims to characterize the continuum of HCV screening and treatment among PWH in HIV care.

Setting: Adult patients enrolled at 12 sites of the HIV Research Network located in three regions of the United States were included. Read More

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http://dx.doi.org/10.1097/QAI.0000000000001949DOI Listing
January 2019
1 Read

Drivers of HIV infection among cisgender and transgender female sex worker populations in Baltimore city: Results from the SAPPHIRE study.

J Acquir Immune Defic Syndr 2019 Jan 8. Epub 2019 Jan 8.

Johns Hopkins Bloomberg School of Public Health, Baltimore, USA.

Objective: To determine and compare risk factors for HIV infection among cisgender female (CFSW) and transgender female (TFSW) sex workers.

Design: Baseline data from a cohort study (SAPPHIRE) of street-based CFSW and TFSW in Baltimore, MD.

Methods: Women were queried about individual (e. Read More

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http://dx.doi.org/10.1097/QAI.0000000000001959DOI Listing
January 2019

Efficacy and Safety of Tenofovir Disoproxil Fumarate Versus Low-Dose Stavudine Over 96 Weeks: A Multicountry Randomized, Noninferiority Trial.

J Acquir Immune Defic Syndr 2019 Feb;80(2):224-233

Chennai Antiviral Research and Treatment Clinical Research Site, YRGCARE Medical Centre, Voluntary Health Services, Chennai, India.

Background: Reducing doses of antiretroviral drugs, including stavudine (d4T), may lower toxicity, while preserving efficacy. There are substantial concerns about renal and bone toxicities of tenofovir disoproxil fumarate (TDF).

Setting: HIV-1-infected treatment-naive adults in India, South Africa, and Uganda. Read More

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http://dx.doi.org/10.1097/QAI.0000000000001908DOI Listing
February 2019
1 Read

Brief Report: Role of Sociobehavioral Factors in Subprotective TFV-DP Levels Among YMSM Enrolled in 2 PrEP Trials.

J Acquir Immune Defic Syndr 2019 Feb;80(2):160-165

Department of Psychiatry, Stroger Hospital of Cook County, Chicago, IL.

Background: Young men who have sex with men (YMSM) experience disparities in HIV acquisition more than any other group. Daily oral pre-exposure prophylaxis (PrEP) with tenofovir/emtricitabine has been shown to effectively prevent HIV transmission in YMSM; however, recent studies suggest that young Black men who have sex with men experience subprotective levels of tenofovir diphosphate more frequently than other groups.

Setting: Combined data from Adolescent Medicine Trials Network for HIV/AIDS Interventions (ATN) 110/113, 2 open-label PrEP studies that provided PrEP and evidence-based behavioral interventions to YMSM aged 15-22 years. Read More

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http://dx.doi.org/10.1097/QAI.0000000000001901DOI Listing
February 2019
4 Reads

Authors' Reply to Comments on "Cardiovascular Risk Profile of Transgender Women with HIV: A U.S. Healthcare Database Study".

J Acquir Immune Defic Syndr 2019 Jan 9. Epub 2019 Jan 9.

Massachusetts General Hospital and Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1097/QAI.0000000000001944DOI Listing
January 2019
6 Reads

Virological outcome of patients with HIV drug resistance attending an urban out-patient clinic in Uganda: a need for structured adherence counselling and third line treatment options.

J Acquir Immune Defic Syndr 2019 Jan 9. Epub 2019 Jan 9.

These authors contributed to the manuscript equally.

Background: HIV drug resistance and suboptimal adherence are the main reasons for treatment failure among HIV-infected individuals. As genotypic resistance testing is not routinely available in resource-limited settings such as Uganda, data on transmitted and acquired resistance is sparse.

Methods: This observational follow-up study assessed the virological outcomes of patients diagnosed with virological failure or transmitted HIV drug resistance in 2015 at the adults' out-patient clinic of the Infectious Diseases Institute in Kampala, Uganda. Read More

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http://dx.doi.org/10.1097/QAI.0000000000001943DOI Listing
January 2019
4 Reads

Young women's stated preferences for biomedical HIV prevention: results of a discrete choice experiment in Kenya and South Africa.

J Acquir Immune Defic Syndr 2019 Jan 9. Epub 2019 Jan 9.

RTI Health Solutions, Research Triangle Park, NC, USA.

Background: Integrating end-user perspectives into the design of new biomedical HIV prevention products is recognized as vital to informing the product development pipeline.

Setting: Kisumu, Kenya; Soshanguve, South Africa METHODS:: We conducted a discrete choice experiment survey with 536 women aged 18-30 to assess preferences for hypothetical HIV prevention products characterized by the attributes of efficacy, pregnancy prevention, delivery form, dosing frequency and side effects. Participants included product-experienced women from TRIO, a cross-over clinical study evaluating three placebo delivery forms (oral tablets, vaginal rings and injections), and a product-naïve sample recruited from the same communities. Read More

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http://dx.doi.org/10.1097/QAI.0000000000001945DOI Listing
January 2019
5 Reads

A Multiplex HIV Incidence Assay for Inferring Recent HIV-1 Transmission and Time of Infection.

J Acquir Immune Defic Syndr 2019 Jan 7. Epub 2019 Jan 7.

Division of HIV/ AIDS Prevention, National Center for HIV/AIDS, Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA.

Background: Laboratory assays for determining recent HIV-1 infection are an important public health tool for aiding in the estimation of HIV incidence. Some incidence assay analytes are remarkably predictive of time since seroconversion and may be useful for additional applications, such as predicting recent transmission events during HIV outbreaks and informing prevention strategies.

Methods: Plasma samples (n= 154) from a recent HIV-1 outbreak in a rural community in Indiana were tested with the customized HIV-1 Multiplex assay, based on the Bio-Rad Bio-Plex platform, which measures antibody response to HIV envelope antigens, gp120, gp160, and gp41. Read More

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http://dx.doi.org/10.1097/QAI.0000000000001937DOI Listing
January 2019
2 Reads

A patient-centered multi-component strategy for accelerated linkage to care following community-wide HIV testing in rural Uganda and Kenya.

J Acquir Immune Defic Syndr 2018 Dec 20. Epub 2018 Dec 20.

University of Antwerp, Belgium.

Introduction: As countries move towards universal HIV treatment, many individuals fail to link to care following diagnosis of HIV. Efficient and effective linkage strategies are needed.

Methods: We implemented a patient-centered, multi-component linkage strategy in the SEARCH "test-and-treat" trial (NCT 01864603) in Kenya and Uganda. Read More

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http://dx.doi.org/10.1097/QAI.0000000000001939DOI Listing
December 2018
6 Reads

Aetiology and severity of liver disease in HIV positive patients with suspected NAFLD: lessons from a cohort with available liver biopsies.

J Acquir Immune Defic Syndr 2018 12 12. Epub 2018 Dec 12.

UCL Institute for Liver and Digestive Health, Royal Free Hospital and UCL, London, UK.

Background: Spectrum of liver injury among HIV positive people is wide; in particular prevalence of non-alcoholic fatty liver disease (NAFLD) seems to be higher compared to HIV-negative people.

Methods: We retrospectively evaluated all liver biopsies performed at Royal Free Hospital from 2000 to 2017 in HIV mono-infected patients with abnormal transaminases, in order to assess the underlying cause of liver disease and to characterize the extent of fibrosis. We furthermore evaluated the diagnostic accuracy of FIB4 and Fibroscan™ as non-invasive tools for fibrosis assessment. Read More

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http://dx.doi.org/10.1097/QAI.0000000000001942DOI Listing
December 2018
2 Reads

Diagnostic accuracy of noninvasive markers of steatosis, NASH and liver fibrosis in HIV-monoinfected individuals at-risk of non-alcoholic fatty liver disease (NAFLD): results from the ECHAM study.

J Acquir Immune Defic Syndr 2018 Dec 12. Epub 2018 Dec 12.

INSERM, Sorbonne Université, Institut Pierre Louis d'Épidémiologie et de Santé Publique (IPLESP), Paris, France.

Background: HIV-monoinfected individuals are at high risk of non-alcoholic fatty liver disease (NAFLD). Non-invasive tests of steatosis, nonalcoholic steatohepatitis (NASH) and fibrosis have been poorly assessed in this population. Using liver biopsy (LB) as a reference, we assessed the accuracy of noninvasive methods for their respective diagnosis: MRI proton-density-fat-fraction (MRI-PDFF), Fibroscan®/CAP and biochemical tests. Read More

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http://dx.doi.org/10.1097/QAI.0000000000001936DOI Listing
December 2018
2 Reads
4.556 Impact Factor

Social networks and its impact on women's awareness, interest, and uptake of HIV pre-exposure prophylaxis (PrEP): Implications for women experiencing intimate partner violence.

J Acquir Immune Defic Syndr 2018 Dec 12. Epub 2018 Dec 12.

Department of Social and Behavioral Sciences, Yale School of Public Health, 60 College Street, New Haven, CT 06520.

Background: In the U.S., women represent less than 5% of all pre-exposure prophylaxis (PrEP) users. Read More

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http://dx.doi.org/10.1097/QAI.0000000000001935DOI Listing
December 2018

Antiretroviral drug concentrations in breastmilk, maternal HIV viral load, and HIV transmission to the infant: results from the BAN study.

J Acquir Immune Defic Syndr 2018 Dec 12. Epub 2018 Dec 12.

Division of Reproductive Health, Centers for Disease Control and Prevention, Atlanta, GA, USA.

Background: Concentration of antiretroviral (ARV) drug found in plasma, and amounts of drug excreted into breastmilk, may affect HIV viral load and potentially perinatal HIV transmission.

Methods: In this cohort study with two-phase sampling, we included mothers randomized to postpartum maternal ARVs or daily infant nevirapine during 28 weeks of breastfeeding in the Breastfeeding, Antiretrovirals and Nutrition (BAN) study. Among these, we included all mothers who transmitted HIV to their infants between 2-28 weeks and 15% of mothers who did not (n=27 and 227, respectively). Read More

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http://dx.doi.org/10.1097/QAI.0000000000001941DOI Listing
December 2018

Nadir CD4 is negatively associated with antinuclear antibody detection in HCV/HIV coinfected patients.

J Acquir Immune Defic Syndr 2018 Dec 12. Epub 2018 Dec 12.

Université de Nice-Sophia Antipolis, Nice, France.

Background: HCV and HIV infections are associated with higher risk of autoimmune diseases and T-cell dysfunction.

Setting: We evaluate prevalence and factors associated with the presence of autoimmune antinuclear (ANA), anti-smooth muscle actin (aSMA) and anti-liver kidney microsomes (aLKM1) antibodies (Ab) in HCV/HIV coinfected patients during the post-cART era.

Methods: cross-sectional observational study, nested in the ANRS CO13 HEPAVIH cohort (NCT number: NCT03324633). Read More

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http://dx.doi.org/10.1097/QAI.0000000000001940DOI Listing
December 2018
1 Read
4.556 Impact Factor

Retention in care trajectories of HIV-positive individuals participating in a universal test and treat programme in rural South Africa (ANRS 12249 TasP trial).

J Acquir Immune Defic Syndr 2018 Dec 18. Epub 2018 Dec 18.

Aix Marseille Univ, INSERM, IRD, SESSTIM, Sciences Economiques & Sociales de la Santé & Traitement de l'Information Médicale, Marseille, France.

Objective: To study retention in care (RIC) trajectories and associated factors in patients eligible for antiretroviral treatment (ART) in a universal test-and-treat setting (TasP trial, South Africa, 2012-2016).

Design: A cluster-randomized trial whereby individuals identified HIV-positive after home-based testing were invited to initiate ART immediately (intervention) or following national guidelines (control).

Methods: Exiting care was defined as ≥3 months late for a clinic appointment, transferring elsewhere, or death. Read More

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http://dx.doi.org/10.1097/QAI.0000000000001938DOI Listing
December 2018
5 Reads

Birth Defects After Exposure to Efavirenz-Based Antiretroviral Therapy at Conception/First Trimester of Pregnancy: A Multicohort Analysis.

J Acquir Immune Defic Syndr 2019 Mar;80(3):316-324

Service of Obstetrics, Department of Obstetrics and Gynecology, Faculty of Medicine, University Hospitals of Geneva, Geneva, Switzerland.

Background: To investigate the association between efavirenz (EFV) use during conception or first trimester (T1) of pregnancy and the occurrence of birth defects.

Setting: Seven observational studies of pregnant HIV-positive women across 13 European countries and Thailand.

Methods: Individual-level data were pooled on singleton pregnancies included in participating cohorts in 2002-2015. Read More

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http://dx.doi.org/10.1097/QAI.0000000000001922DOI Listing
March 2019
2 Reads

Full-Genome Analysis of Hepatitis C Virus in Japanese and Non-Japanese Patients Coinfected With HIV-1 in Tokyo.

J Acquir Immune Defic Syndr 2019 Mar;80(3):350-357

AIDS Clinical Center, National Center for Global Health and Medicine, Tokyo, Japan.

Background: Acute hepatitis C virus (HCV) infection is increasing among HIV-1-infected individuals in Tokyo. Appropriate clinical management is needed.

Setting: To delineate the epidemiological status of HCV transmission, we analyzed stocked plasma samples of HCV/HIV-1-coinfected patients seen at the largest referral center for HIV care in Tokyo. Read More

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http://dx.doi.org/10.1097/QAI.0000000000001919DOI Listing
March 2019
3 Reads

Effect of Macrolide Prophylactic Therapy on AIDS-Defining Conditions and HIV-Associated Mortality.

J Acquir Immune Defic Syndr 2018 Dec 10. Epub 2018 Dec 10.

Research Institute for Tropical Medicine, Muntinlupa City, Philippines.

Background: Mycobacterium avium complex (MAC) prophylaxis is recommended for patients with advanced HIV infection. With the decrease in incidence of disseminated MAC infection and the availability of antiretroviral therapy (ART), the benefits of macrolide prophylaxis were investigated. This study examined the impact of macrolide prophylaxis on AIDS-defining conditions and HIV-associated mortality in a cohort of HIV-infected patients on ART. Read More

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http://dx.doi.org/10.1097/QAI.0000000000001933DOI Listing
December 2018
2 Reads

Individual and sexual network predictors of HIV incidence among men who have sex with men in Nigeria.

J Acquir Immune Defic Syndr 2018 Dec 10. Epub 2018 Dec 10.

Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD, USA.

Background: To date, HIV incidence studies among men who have sex with men (MSM) across sub-Saharan Africa have focused on studying sexual risk practices with less focus on sexual networks.

Setting: TRUST/RV368 conducted in Abuja and Lagos, Nigeria recruited MSM using respondent driven sampling (RDS) and followed HIV negative men for incident infection over 4 years.

Methods: Four-hundred forty-one HIV-uninfected MSM underwent a parallel rapid HIV testing algorithm every 3 months for up to 18 months. Read More

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http://dx.doi.org/10.1097/QAI.0000000000001934DOI Listing
December 2018
3 Reads

Buffering Internalization of HIV Stigma: Implications for Treatment Adherence and Depression.

J Acquir Immune Defic Syndr 2019 Mar;80(3):284-291

Department of Health Care Organization and Policy, School of Public Health, University of Alabama at Birmingham, Birmingham, AL.

Background: One mechanism through which social stigma of HIV affects health outcomes for people living with HIV (PLWH) is through internalization of stigma. However, this transformation of social stigma in the community into internalized stigma may not be of the same magnitude for all PLWH. We examined the moderating effects of 3 personality traits-fear of negative social evaluation, attachment-related anxiety, and dispositional resilience-in transforming perceived stigma in the community into internalized stigma. Read More

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http://dx.doi.org/10.1097/QAI.0000000000001915DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375772PMC