344,645 results match your criteria Italian heart journal : official journal of the Italian Federation of Cardiology[Journal]


Assessing the Role of Anti rh-GAA in Modulating Response to ERT in a Late-Onset Pompe Disease Cohort from the Italian GSDII Study Group.

Adv Ther 2019 Mar 16. Epub 2019 Mar 16.

Department of Clinical and Experimental Medicine, UOC di Neurologia e Malattie Neuromuscolari, University of Messina, Messina, Italy.

Introduction: Patients with late-onset Pompe disease (LOPD) receiving enzyme replacement therapy (ERT) may develop IgG antibodies against alglucosidase alpha (anti-rhGAA) in the first 3 months of treatment. The exact role of these antibodies in modulating efficacy of ERT in this group of patients is still not fully understood. To assess whether anti rh-GAA antibodies interfere with ERT efficacy, we studied a large Italian cohort of LOPD patients. Read More

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http://dx.doi.org/10.1007/s12325-019-00926-5DOI Listing

The smoking epidemic across generations, genders, and educational groups: A matter of diffusion of innovations.

Econ Hum Biol 2019 Mar 7;33:155-168. Epub 2019 Mar 7.

Department of Economics and Management, University of Pavia, via San Felice, 5, Pavia, Italy. Electronic address:

This study determines whether the temporal variations in smoking habits across generations and genders and among groups with differing levels of education fit the pattern proposed by the theory of the diffusion of innovations (TDI) (Rogers, 2003). We focus on the Italian case and employ a pseudo-panel derived from repeated cross-sections of the annual household survey, "Aspects of Daily Life," that was part of the Multipurpose Survey carried out by the Italian National Statistical Office (ISTAT) for the period 1997 to 2012. The results confirm Rogers' TDI and show that smoking prevalence has declined over time and across age cohorts: Younger men of all educational levels and women with higher education are less likely to smoke than are those in other cohorts, while less-educated women who entered the smoking-diffusion process later than others are more likely to smoke. Read More

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http://dx.doi.org/10.1016/j.ehb.2019.01.003DOI Listing

F-actin dynamics regulates mammalian organ growth and cell fate maintenance.

J Hepatol 2019 Mar 13. Epub 2019 Mar 13.

Department of Molecular Medicine DMM, University of Padova, Italy. Electronic address:

Background & Aims: In vitro, several data indicate that cell function can be regulated by the mechanical properties of cells and of the microenvironment. Cells measure these features by developing forces via their actomyosin cytoskeleton, and respond accordingly by transducing forces into biochemical signals that instruct cell behavior. Among these, the transcriptional coactivators YAP/TAZ recently emerged as key factors mediating multiple responses to actomyosin contractility. Read More

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http://dx.doi.org/10.1016/j.jhep.2019.02.022DOI Listing

Comparative analysis of chemical composition, antioxidant and anti-proliferative activities of Italian Vitis vinifera by-products for a sustainable agro-industry.

Food Chem Toxicol 2019 Mar 13. Epub 2019 Mar 13.

Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036, Rende, CS, Italy.

Vitis vinifera leaves are wine industry wastes. In this study, the chemical composition, antioxidant and anti-proliferative activity of six Italian grapevine leaves extracts (Arvino, Gaglioppo, Greco Nero, Magliocco Canino, Magliocco Dolce, and Nocera) were evaluated. HPLC analyses revealed quercetin as dominant constituent (127. Read More

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http://dx.doi.org/10.1016/j.fct.2019.03.007DOI Listing

Dirofilaria immitis and D. repens in dog and cat: A questionnaire study in Italy.

Vet Parasitol 2019 Mar 13;267:26-31. Epub 2019 Feb 13.

Department of Veterinary Sciences, University of Parma, Parma, Italy.

Dirofilaria immitis and D. repens are vector-borne parasites of dogs and cats, with zoonotic potential, endemic in many parts of Europe, including Italy. Control and prevention of dirofilariosis are essential points to reduce their diffusion in animals and humans and veterinarians are the main subjects involved in this "battle". Read More

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http://dx.doi.org/10.1016/j.vetpar.2019.01.014DOI Listing

Secondary breast angiosarcoma: A multicentre retrospective survey by the national Italian association of Breast Surgeons (ANISC).

Breast 2019 Mar 7;45:56-60. Epub 2019 Mar 7.

IEO, Milano, Italy.

Background: Breast angiosarcoma is a malignant mesenchymal neoplasm, which accounts for approximately 2% of all soft tissue sarcomas. Secondary breast angiosarcoma (SBA) may be related to chronic lymphedema after a mastectomy with lymph node dissection (Stewart Treves syndrome) and previous radiotherapy for complications from breast radiation treatment. It is a very rare condition; therefore, diagnosis and management are still a challenge. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09609776193003
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http://dx.doi.org/10.1016/j.breast.2019.02.011DOI Listing
March 2019
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Genetic diversity of Flavescence dorée phytoplasmas at vineyard scale.

Appl Environ Microbiol 2019 Mar 15. Epub 2019 Mar 15.

Istituto per la Protezione Sostenibile delle Piante, CNR, Strada delle Cacce 73, 10135 Torino, Italy

To study the role of wild areas around the vineyards in the epidemiology of Flavescence dorée (FD) and track origin of new foci, two phytoplasma genetic markers, K and G, were developed for FD phytoplasma characterization. The two genes and the A locus were used to genetically characterize FDp populations at seven agroecosystems of a wine-growing Italian region. , "gone-wild" and rootstocks, spp. Read More

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http://dx.doi.org/10.1128/AEM.03123-18DOI Listing
March 2019
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A special case of medicine in disguise: Tattoo inks containing anaesthetics.

Talanta 2019 Jun 7;198:337-343. Epub 2019 Feb 7.

National Centre for the Control and Evaluation of Medicines, Italian National Institute of Health, Viale Regina Elena 299, 00161 Rome, Italy.

This paper describes a case of medicine in disguise: seized tattoo inks containing lidocaine and tetracaine at high concentration. Identification of anaesthetics was performed by LC MS Q-TOF with ESI source, by accurate mass measurement and by comparing the fragmentation patterns of molecular ions, at 30 V and 10 V of collision-offset voltage, with reference standards. Quantification was also performed by LC MS Q-TOF on the chromatographic peaks in the extracted ion chromatograms, by calibration curves obtained at different standard concentrations and by standard additions approach. Read More

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http://dx.doi.org/10.1016/j.talanta.2019.02.033DOI Listing

Increased Levels of cAMP by the Calcium-Dependent Activation of Soluble Adenylyl Cyclase in -Mutant Fibroblasts.

Cells 2019 Mar 15;8(3). Epub 2019 Mar 15.

Department of Basic Medical Sciences, Neurosciences and Sensory Organs, University of Bari "Aldo Moro", 70124 Bari, Italy.

Almost half of autosomal recessive early-onset parkinsonism has been associated with mutations in , coding for parkin, which plays an important role in mitochondria function and calcium homeostasis. Cyclic adenosine monophosphate (cAMP) is a major second messenger regulating mitochondrial metabolism, and it is strictly interlocked with calcium homeostasis. -mutant (Pt) fibroblasts, exhibiting defective mitochondrial respiratory/OxPhos activity, showed a significant higher value of basal intracellular level of cAMP, as compared with normal fibroblasts (CTRL). Read More

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http://dx.doi.org/10.3390/cells8030250DOI Listing
March 2019
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Cost-effectiveness of second-line diagnostic investigations in patients included in the DANTE trial: a randomized controlled trial of lung cancer screening with low-dose computed tomography.

Nucl Med Commun 2019 Mar 11. Epub 2019 Mar 11.

Department of Thoracic Surgery, AIOU, Verona, Italy.

Aim: The aim of this study was to analyze the economic efficiency of second-line diagnostic investigations in patients with undetermined lung nodules.

Participants And Methods: A retrospective review of all surgical cases included in the DANTE trial from 2001 to 2006 for lung cancer screening was performed. Overall, 217 patients and 261 lung nodules were analyzed. Read More

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http://dx.doi.org/10.1097/MNM.0000000000000993DOI Listing

Therapeutic sequences in patients with grade 1-2 neuroendocrine tumors (NET): an observational multicenter study from the ELIOS group.

Endocrine 2019 Mar 14. Epub 2019 Mar 14.

Division of Endocrinology, Department of Clinical Medicine and Surgery, Federico II University of Naples, Naples, Italy.

Purpose: Many different treatments are suggested by guidelines to treat grade 1-2 (G1-G2) neuroendocrine tumors (NET). However, a precise therapeutic algorithm has not yet been established. This study aims at identifying and comparing the main therapeutic sequences in G1-G2 NET. Read More

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http://dx.doi.org/10.1007/s12020-019-01894-0DOI Listing

Correction to: EuroSurg-1 study: an opportunity to encourage student-driven surgical research in Italy.

Authors:

Tech Coloproctol 2019 Mar 14. Epub 2019 Mar 14.

Unfortunately, the collaborators of the above mentioned article was missed out in the affiliation of the original publication. The details of them are listed below. Read More

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http://dx.doi.org/10.1007/s10151-019-01958-3DOI Listing

Use of FCC-NMRD relaxometry for early detection and characterization of ex-vivo murine breast cancer.

Sci Rep 2019 Mar 15;9(1):4624. Epub 2019 Mar 15.

Department of Molecular Biotechnology and Health Sciences, Via Nizza 52, 10126, Torino, Italy.

Breast Cancer is the most diffuse cancer among women and the treatment outcome is largely determined by its early detection. MRI at fixed magnetic field is already widely used for cancer detection. Herein it is shown that the acquisition of proton T at different magnetic fields adds further advantages. Read More

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http://dx.doi.org/10.1038/s41598-019-41154-9DOI Listing

The B-cell receptor in control of tumor B-cell fitness: Biology and clinical relevance.

Immunol Rev 2019 Mar;288(1):198-213

Department of Molecular and Translational Medicine, Section of Pathology, University of Brescia, Brescia, Italy.

Surface expression of a functional B cell antigen receptor (BCR) is essential for the survival and proliferation of mature B cells. Most types of B-cell lymphoproliferative disorders retain surface BCR expression, including B-cell non-Hodgkin lymphomas (B-NHL) and chronic lymphocytic leukemia (CLL). Targeting BCR effectors in B-NHL cell lines in vitro has indicated that this signaling axis is crucial for malignant B cell growth. Read More

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http://dx.doi.org/10.1111/imr.12738DOI Listing

MYC in Germinal Center-derived lymphomas: Mechanisms and therapeutic opportunities.

Immunol Rev 2019 Mar;288(1):178-197

Department of Experimental Oncology, IEO, European Institute of Oncology IRCCS, Milan, Italy.

The rearrangement of immunoglobulin loci during the germinal center reaction is associated with an increased risk of chromosomal translocations that activate oncogenes such as MYC, BCL2 or BCL6, thus contributing to the development of B-cell lymphomas. MYC and BCL2 activation are initiating events in Burkitt's (BL) and Follicular Lymphoma (FL), respectively, but can occur at later stages in other subtypes such as Diffuse Large-B Cell Lymphoma (DLBCL). MYC can also be activated during the progression of FL to the transformed stage. Read More

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http://dx.doi.org/10.1111/imr.12734DOI Listing

Using Harter and Likert Response Formats in Middle Childhood: A Comparison of Attachment Measures.

Assessment 2019 Mar 15:1073191119836497. Epub 2019 Mar 15.

1 University of Padova, Padova, Italy.

Self-report questionnaires based on Harter's response format ("Some kids . . . Read More

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http://dx.doi.org/10.1177/1073191119836497DOI Listing
March 2019
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First Report of the Italian Registry on Immune-Mediated Congenital Heart Block (Lu.Ne Registry).

Front Cardiovasc Med 2019 28;6:11. Epub 2019 Feb 28.

Struttura Complessa Medicina Interna, ASST Papa Giovanni XXIII, Bergamo, Italy.

Neonatal Lupus (NL) is a rare syndrome caused by placental transfer of maternal anti-SSA/Ro and anti-La/SSB autoantibodies to the fetus. The rarity of this condition requires the establishment of multidisciplinary registries in order to improve our knowledge. Inclusion criteria in this retrospective study were the maternal confirmed positivity for anti-SSA/Ro and/or anti-SSB/La antibodies, and the presence of II or III degree congenital heart block (CHB) or neonatal period (up to 27 days after birth). Read More

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https://www.frontiersin.org/article/10.3389/fcvm.2019.00011/
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http://dx.doi.org/10.3389/fcvm.2019.00011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404544PMC
February 2019
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Lipomatosis Incidence and Characteristics in an Italian Cohort of Mitochondrial Patients.

Front Neurol 2019 27;10:160. Epub 2019 Feb 27.

Department of Clinical and Experimental Medicine, UOC Neurologia e Malattie Neuromuscolari, University of Messina, Messina, Italy.

Lipomas have often been associated with mtDNA mutations and were mainly observed in patients with mutation in mitochondrial tRNAlysine which is also the most frequent mutation associated with MERRF. Up to date, no systematic studies have been developed in order to assess the incidence of lipomas in large cohorts of mitochondrial patients.The aim of this study is to analyze the incidence and characteristics of lipomas among an Italian cohort of patients with mitochondrial diseases. Read More

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https://www.frontiersin.org/article/10.3389/fneur.2019.00160
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http://dx.doi.org/10.3389/fneur.2019.00160DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402385PMC
February 2019
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Stream benthic macroinvertebrates abundances over a 6-year monitoring period of an Italian glacier-fed stream.

Biodivers Data J 2019 6;7:e33576. Epub 2019 Mar 6.

Institute for Alpine Environment, EURAC Research, Bolzano, Italy Institute for Alpine Environment, EURAC Research Bolzano Italy.

Background: Aquatic macroinvertebrates are widely used as bioindicators for water quality assessments involving different kinds of disruptive factors, such as hydrological regime variations or pollutant spills. Recently, they demonstrated to be effective in monitoring effects of climate change in alpine stream and rivers. Indeed, since the distribution of macroinvertebrates in glacier-fed streams has been succesfully investigated and described by several authors, the discrepancy in presence/absence and quantity of specific taxa from the established models may represent an early warning of the effects of climatic changes occurring in alpine riverine ecosystems. Read More

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http://dx.doi.org/10.3897/BDJ.7.e33576DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416225PMC

Inhibition of SYK or BTK augments venetoclax sensitivity in SHP1-negative/BCL-2-positive diffuse large B-cell lymphoma.

Leukemia 2019 Mar 14. Epub 2019 Mar 14.

Molecular Hematology, International Centre for Genetic Engineering and Biotechnology, Trieste, Italy.

The BCL-2 inhibitor venetoclax has only limited activity in DLBCL despite frequent BCL-2 overexpression. Since constitutive activation of the B cell receptor (BCR) pathway has been reported in both ABC and GCB DLBCL, we investigated whether targeting SYK or BTK will increase sensitivity of DLBCL cells to venetoclax. We report that pharmacological inhibition of SYK or BTK synergistically enhances venetoclax sensitivity in BCL-2-positive DLBCL cell lines with an activated BCR pathway in vitro and in a xenograft model in vivo, despite the only modest direct cytotoxic effect. Read More

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http://dx.doi.org/10.1038/s41375-019-0442-8DOI Listing

Androgens Induce Invasiveness of Triple Negative Breast Cancer Cells Through AR/Src/PI3-K Complex Assembly.

Sci Rep 2019 Mar 14;9(1):4490. Epub 2019 Mar 14.

Department of Precision Medicine, University of Campania 'L. Vanvitelli', Via L. De Crecchio, 7, 80138, Naples, Italy.

Breast cancer (BC) is still characterized by high morbidity and mortality. A specific BC subtype named triple negative BC (TNBC) lacks estrogen and progesterone receptors (ER and PR, respectively) and is characterized by the absence of overexpression/amplification of human epidermal growth factor receptor 2 (HER2). The androgen receptor (AR) is expressed in TNBC, although its function in these cancers is still debated. Read More

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http://dx.doi.org/10.1038/s41598-019-41016-4DOI Listing

MC1R variants in childhood and adolescent melanoma: a retrospective pooled analysis of a multicentre cohort.

Lancet Child Adolesc Health 2019 Mar 11. Epub 2019 Mar 11.

Molecular and Pharmaco-Epidemiology Unit, Department of Experimental Oncology, European Institute of Oncology IRCCS, Milan, Italy. Electronic address:

Background: Germline variants in the melanocortin 1 receptor gene (MC1R) might increase the risk of childhood and adolescent melanoma, but a clear conclusion is challenging because of the low number of studies and cases. We assessed the association of MC1R variants with childhood and adolescent melanoma in a large study comparing the prevalence of MC1R variants in child or adolescent patients with melanoma to that in adult patients with melanoma and in healthy adult controls.

Methods: In this retrospective pooled analysis, we used the M-SKIP Project, the Italian Melanoma Intergroup, and other European groups (with participants from Australia, Canada, France, Greece, Italy, the Netherlands, Serbia, Spain, Sweden, Turkey, and the USA) to assemble an international multicentre cohort. Read More

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http://dx.doi.org/10.1016/S2352-4642(19)30005-7DOI Listing

Use of biosimilars in inflammatory bowel disease: A position update of the Italian Group for the Study of Inflammatory Bowel Disease (IG-IBD).

Dig Liver Dis 2019 Feb 19. Epub 2019 Feb 19.

IBD Unit, Presidio Columbus, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy; Università Cattolica del Sacro Cuore, Rome, Italy. Electronic address:

The first infliximab biosimilar for the treatment of inflammatory bowel disease (IBD) was introduced in 2013, and today eight anti-TNF alpha biosimilars (three for infliximab and five for adalimumab) have been approved and licensed by the European Medicines Agency. Biosimilars present great potential in terms of cost saving and possible consequential reinvestment in the health care system. The increasing knowledge about the process of biosimilar development and use in IBD and the publication of many prospective clinical studies and real-life clinical experiences have progressively changed the point of view of IBD physicians. Read More

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http://dx.doi.org/10.1016/j.dld.2019.02.004DOI Listing
February 2019

iTalian RegIstry of doUble inner branch stent graft for arch PatHology (the TRIUmPH Registry).

J Vasc Surg 2019 Mar 11. Epub 2019 Mar 11.

Unit of Vascular Surgery, Department of Surgery "Pietro Valdoni", Sapienza University of Rome, Rome, Italy.

Objective: The objective of this study was to assess early and midterm results after endovascular aortic arch repair using a double inner branch stent graft (DIBSG) in patients with aortic arch aneurysm or dissection unfit for open surgery.

Methods: Between 2012 and 2018, there were 24 patients with aortic arch disease who were treated with a single model of a DIBSG (Terumo Aortic, Glasgow, United Kingdom) in nine Italian cardiovascular centers. We investigated technical success, mortality, occurrence of major complications, and need for reintervention in a multicenter, nonrandomized, retrospective fashion. Read More

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http://dx.doi.org/10.1016/j.jvs.2018.11.046DOI Listing

Standardised profiling for tinnitus research: The European School for Interdisciplinary Tinnitus Research Screening Questionnaire (ESIT-SQ).

Hear Res 2019 Mar 2. Epub 2019 Mar 2.

NIHR Nottingham Biomedical Research Centre, 113 The Ropewalk, Nottingham, NG1 5DU, UK; Hearing Sciences, Division of Clinical Neuroscience, School of Medicine, University of Nottingham, Building 40 University Park, Nottingham, NG7 2RD, UK; Nottingham University Hospitals NHS Trust, Queens Medical Centre, Derby Road, Nottingham, NG7 2UH, UK; University of Nottingham Malaysia, Jalan Broga, 43500, Semeniyh, Selangor Darul Ehsan, Malaysia.

Background: The heterogeneity of tinnitus is substantial. Its numerous pathophysiological mechanisms and clinical manifestations have hampered fundamental and treatment research significantly. A decade ago, the Tinnitus Research Initiative introduced the Tinnitus Sample Case History Questionnaire, a case history instrument for standardised collection of information about the characteristics of the tinnitus patient. Read More

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http://dx.doi.org/10.1016/j.heares.2019.02.017DOI Listing

The Path of Cicely Saunders: The "Peculiar Beauty" of Palliative Care.

J Palliat Care 2019 Mar 14:825859719833659. Epub 2019 Mar 14.

20 Palliative Care Unit, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy.

This paper is aimed at focusing on the writings and the experience of the Hospice movemente Founder, Dame Cicely Saunders. The in-depth analysis carried out had the objective of verifying if "the way" of Cicely to understand, live and propose palliative care was still current and "beautiful", so that we can nowadays refer to her fascinating "Original Palliative Care". With "beauty" we mean, on the one hand, a way able to allow a personal path of research of the meaning of the disease and of the care, both for those who care and for those who are cared for. Read More

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http://dx.doi.org/10.1177/0825859719833659DOI Listing

HABITAT: An IoT Solution for Independent Elderly.

Sensors (Basel) 2019 Mar 12;19(5). Epub 2019 Mar 12.

CIRI-Information and Communication Technologies, University of Bologna, 40126 Bologna, Italy.

In this work, a flexible and extensive digital platform for Smart Homes is presented, exploiting the most advanced technologies of the Internet of Things, such as Radio Frequency Identification, wearable electronics, Wireless Sensor Networks, and Artificial Intelligence. Thus, the main novelty of the paper is the system-level description of the platform flexibility allowing the interoperability of different smart devices. This research was developed within the framework of the operative project HABITAT (Home Assistance Based on the Internet of Things for the Autonomy of Everybody), aiming at developing smart devices to support elderly people both in their own houses and in retirement homes, and embedding them in everyday life objects, thus reducing the expenses for healthcare due to the lower need for personal assistance, and providing a better life quality to the elderly users. Read More

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https://www.mdpi.com/1424-8220/19/5/1258
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http://dx.doi.org/10.3390/s19051258DOI Listing
March 2019
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The Impact of Intermittent Fasting (Ramadan Fasting) on Psoriatic Arthritis Disease Activity, Enthesitis, and Dactylitis: A Multicentre Study.

Nutrients 2019 Mar 12;11(3). Epub 2019 Mar 12.

NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, LS7 4SA Leeds, UK.

Intermittent circadian fasting, namely Ramadan, is a common worldwide practice. Such fasting has a positive impact on psoriasis, but no data exist on its role in psoriatic arthritis (PsA)-a disease that is clearly linked to body mass index. We enrolled 37 patients (23 females and 14 males) with a mean age 43. Read More

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http://dx.doi.org/10.3390/nu11030601DOI Listing

Soft tissue sarcoma in Italy: From epidemiological data to clinical networking to improve patient care and outcomes.

Cancer Epidemiol 2019 Mar 11;59:258-264. Epub 2019 Mar 11.

Division of Medical Oncology Candiolo Cancer Institute - FPO, IRCCS, Strada Provinciale 142, 10060 Candiolo, Torino, Italy.

Sarcomas are rare malignant neoplasms that develop from mesenchymal cells and include a heterogeneous and large group of histological subtypes that may occur at any anatomical site. Soft tissue sarcomas (STS), the focus of this review, account for ≈70‒80% of sarcomas and represent <1% of all cancers. The heterogeneity of STS applies to both their topography and morphology, and 5-year survival can vary widely depending on disease stage and the complex interplay between anatomical site and histology for different STS subtypes. Read More

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http://dx.doi.org/10.1016/j.canep.2019.02.012DOI Listing

Lack of association of metastasis-associated lung adenocarcinoma transcript 1 variants with melanoma skin cancer risk.

Melanoma Res 2019 Mar 11. Epub 2019 Mar 11.

Section of Biology and Genetics, Department of Neurosciences, Biomedicine and Movement Sciences.

The long noncoding RNA (lncRNA) metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) has been implicated in melanoma. Polymorphisms in MALAT1 may play a vital role in the progress of melanoma by its regulative function. However, potential genetic variants in MALAT1 affecting the risk of melanoma onset have not been explored. Read More

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http://dx.doi.org/10.1097/CMR.0000000000000605DOI Listing

Dietary Restrictions and Nutrition in the Prevention and Treatment of Cardiovascular Disease.

Circ Res 2019 Mar;124(6):952-965

From the Longevity Institute, Davis School of Gerontology, University of Southern California, Los Angeles (S.B., V.D.L.).

Cardiovascular disease (CVD) is the leading cause of death in many developed countries and remains one of the major diseases strongly affected by the diet. Nutrition can affect CVD directly by contributing to the accumulation of vascular plaques and also indirectly by regulating the rate of aging. This review summarizes research on nutrition and CVD incidence based on a multipillar system that includes basic research focused on aging, epidemiological studies, clinical studies, and studies of centenarians. Read More

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https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.118.31335
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http://dx.doi.org/10.1161/CIRCRESAHA.118.313352DOI Listing
March 2019
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Trends of hospitalisations rates in a cohort of HIV-infected persons followed in an Italian hospital from 1998 to 2016.

Epidemiol Infect 2019 Jan;147:e89

Fondazione Policlinico Universitario A. Gemelli IRCCS,Roma Italia, UOC Malattie Infettive.

Here we evaluated hospitalisation rates and associated risk factors of human immunodeficiency virus (HIV)-infected individuals who were followed up in an Italian reference hospital from 1998 to 2016. Incidence rates (IR) of hospitalisations were calculated for five study periods from 1998 to 2016. The random-effects Poisson regression model was used to assess risk factors for hospitalisation including demographic and clinical characteristics. Read More

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http://dx.doi.org/10.1017/S0950268819000098DOI Listing
January 2019

Psychological markers of longevity in Sardinian centenarians: the impact of developmental factors and social desirability.

Aging Clin Exp Res 2019 Mar 13. Epub 2019 Mar 13.

Department of Pedagogy, Psychology, Philosophy, University of Cagliari, Via Is Mirrionis 1, 09123, Cagliari, Italy.

A body of research documented that the study of mental health of the oldest individuals may contribute to understand the psychological characteristics of longevity. This study had two related aims. First, to fully characterize the psychological health of Sardinian elders in the very late adult span. Read More

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http://dx.doi.org/10.1007/s40520-019-01157-yDOI Listing

Features, reason for testing, and changes with time of 583 paroxysmal nocturnal hemoglobinuria clones from 529 patients: a multicenter Italian study.

Ann Hematol 2019 Mar 13. Epub 2019 Mar 13.

CEINGE Biotecnologie Avanzate, Naples, Italy.

In this study, we aimed at disclosing the main features of paroxysmal nocturnal hemoglobinuria (PNH) clones, their association with presentation syndromes, and their changes during follow-up. A large-scale, cooperative collection (583 clones from 529 patients) of flow cytometric and clinical data was entered into a national repository. Reason for testing guidelines were provided to the 41 participating laboratories, which followed the 2010 technical recommendations for PNH testing by Borowitz. Read More

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http://dx.doi.org/10.1007/s00277-019-03644-8DOI Listing

Role of Spreader Flaps in Rhinoplasty: Analysis of Patients Undergoing Correction for Severe Septal Deviation with Long-Term Follow-Up.

Aesthetic Plast Surg 2019 Mar 13. Epub 2019 Mar 13.

Plastic and Reconstructive Surgery Unit, Campus Bio-Medico University of Rome, Via Alvaro Del Portillo 200, Rome, Italy.

Introduction: The aim of this randomized controlled study was to analyze the long-term results of patients undergoing rhinoplasty because of severe septal deviation and to evaluate the stability of results.

Materials And Methods: The study was performed with a randomized design. Patients were randomly divided into four groups: group 1, spreader flaps were used in combination with spreader grafts; group 2, spreader flaps were used alone; group 3, spreader grafts were used alone; and group 4, neither spreader flaps nor grafts flaps were used. Read More

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http://dx.doi.org/10.1007/s00266-019-01343-3DOI Listing

Adherence to diabetes care process indicators in migrants as compared to non-migrants with diabetes: a retrospective cohort study.

Int J Public Health 2019 Mar 13. Epub 2019 Mar 13.

Agenzia Regionale Sanità, Regione Toscana, Via Pietro Dazzi, 1, 50141, Florence, Italy.

Objectives: Prevalence rate of diabetes is high among migrants. Whether migrants are correctly addressed to a standard quality of care for diabetes and are properly followed up are the questions addressed by this retrospective cohort study.

Methods: Compliance to one or repeated Guideline Composite Indicator (GCI), a standard process indicator of care quality, was tested in migrants compared to non-migrant Italian residents with diabetes, living in Tuscany Region, Italy, in years 2011-2015. Read More

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http://dx.doi.org/10.1007/s00038-019-01220-5DOI Listing

Reaction intermediates during operando electrocatalysis identified from full solvent quantum mechanics molecular dynamics.

Proc Natl Acad Sci U S A 2019 Mar 13. Epub 2019 Mar 13.

Joint Center for Artificial Photosynthesis, California Institute of Technology, Pasadena, CA 91125;

Electrocatalysis provides a powerful means to selectively transform molecules, but a serious impediment in making rapid progress is the lack of a molecular-based understanding of the reactive mechanisms or intermediates at the electrode-electrolyte interface (EEI). Recent experimental techniques have been developed for operando identification of reaction intermediates using surface infrared (IR) and Raman spectroscopy. However, large noises in the experimental spectrum pose great challenges in resolving the atomistic structures of reactive intermediates. Read More

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http://www.pnas.org/lookup/doi/10.1073/pnas.1821709116
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http://dx.doi.org/10.1073/pnas.1821709116DOI Listing
March 2019
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Cell communication and signaling: how to turn bad language into positive one.

J Exp Clin Cancer Res 2019 Mar 13;38(1):128. Epub 2019 Mar 13.

Experimental Oncology Lab, CRS Development of Biomolecular Therapies, Orthopaedic Rizzoli Institute, Bologna, Italy.

Cell-to-cell communication has a critical role during tumor development and progression, allowing cancer cell to re-program not only the surrounding tumor microenvironment, but also cells located at distant sites. The crosstalk between neoplastic cells and accessory elements, such as immune and stromal cells, fosters several processes that are necessary for tumor progression and dissemination, such as angiogenesis, immune-escape, epithelial-to-mesenchymal transition, invasion and multi-drug resistance. There are several means by which cells communicate to each other, either by direct cell interactions through membrane receptors and ligands, or by releasing soluble molecules, such as growth factors, cytokines and chemokines. Read More

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https://jeccr.biomedcentral.com/articles/10.1186/s13046-019-
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http://dx.doi.org/10.1186/s13046-019-1122-2DOI Listing
March 2019
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Clinical features and genetic analysis of two siblings with startle disease in an Italian family: a case report.

BMC Med Genet 2019 Mar 12;20(1):40. Epub 2019 Mar 12.

Child Neurology and Psychiatry, Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Rome, Italy.

Background: Hyperekplexia also known as Startle disease is a rare neuromotor hereditary disorder characterized by exaggerated startle responses to unexpected auditory, tactile, and visual stimuli and generalized muscle stiffness, which both gradually subside during the first months of life. Although the diagnosis of Hyperekplexia is based on clinical findings, pathogenic variants in five genes have been reported to cause Hyperekplexia, of which GLRA1 accounts for about 80% of cases. Dominant and recessive mutations have been identified in GLRA1 gene as pathogenic variants in many individuals with the familial form of Hyperekplexia and occasionally in simplex cases. Read More

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http://dx.doi.org/10.1186/s12881-019-0779-xDOI Listing

Investigating Volcanic Plumes from Mt. Etna Eruptions of December 2015 by Means of AVHRR and SEVIRI Data.

Sensors (Basel) 2019 Mar 7;19(5). Epub 2019 Mar 7.

School of Engineering, University of Basilicata, 85100 Potenza, Italy.

In early December 2015, a rapid sequence of strong paroxysmal events took place at the Mt. Etna crater area (Sicily, Italy). Intense paroxysms from the Voragine crater (VOR) generated an eruptive column extending up to an altitude of about 15 km above sea level. Read More

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http://dx.doi.org/10.3390/s19051174DOI Listing

Single Cell Oil Production from Undetoxified L. hydrolysate by .

J Microbiol Biotechnol 2019 Feb;29(2):256-267

Italian National Agency for New Technologies, Energy and Sustainable Economic Development (ENEA), C.R. Trisaia S.S. 106 Jonica 75026 Rotondella (MT), Italy.

The use of low-cost substrates represents one key issue to make single cell oil production sustainable. Among low-input crops, . is a perennial herbaceous rhizomatous grass containing both C5 and C6 carbohydrates. Read More

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http://dx.doi.org/10.4014/jmb.1808.08015DOI Listing
February 2019

Very low protein plus ketoacid analogs of essential aminoacids do not confirm superiority of a low protein diet to retard chronic kidney disease progression.

Kidney Res Clin Pract 2019 03 7. Epub 2019 Mar 7.

Conservative Treatment of Chronic Kidney Disease Study Group of the Italian Society of Nephrology, Italy.

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http://dx.doi.org/10.23876/j.krcp.19.006DOI Listing

Clinical features of sleep-related hypermotor epilepsy in relation to the seizure-onset zone: A review of 135 surgically treated cases.

Epilepsia 2019 Mar 13. Epub 2019 Mar 13.

Department of Neurosciences, Center for Epilepsy Surgery "C. Munari,", Hospital Niguarda, Milan, Italy.

Objectives: Sleep-related hypermotor epilepsy (SHE), formerly nocturnal frontal lobe epilepsy, is characterized by abrupt and typically sleep-related seizures with motor patterns of variable complexity and duration. They seizures arise more frequently in the frontal lobe than in the extrafrontal regions but identifying the seizure onset-zone (SOZ) may be challenging. In this study, we aimed to describe the clinical features of both frontal and extrafrontal SHE, focusing on ictal semiologic patterns in order to increase diagnostic accuracy. Read More

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http://doi.wiley.com/10.1111/epi.14690
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http://dx.doi.org/10.1111/epi.14690DOI Listing
March 2019
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New data from the Italian National Register of Congenital Coagulopathies, 2016 Annual Survey.

Blood Transfus 2019 Feb 13. Epub 2019 Feb 13.

Department of Oncology and Molecular Medicine, Italian National Institute of Health, Rome, Italy.

Background: In Italy, the National Register of Congenital Coagulopathies (NRCC) collects epidemiological and therapeutic data from patients affected by haemophilia A (HA), haemophilia B (HB), von Willebrand's disease (vWD) and other rare coagulation disorders. Here we present data from the 2016 annual survey.

Materials And Methods: Data are provided by the Italian Haemophilia Centres, on a voluntary basis. Read More

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http://dx.doi.org/10.2450/2019.0211-18DOI Listing
February 2019

A Comparison of 3 Established Skeletal Age Estimation Methods in an African Group From Benin and an Italian Group From Southern Italy.

Am J Forensic Med Pathol 2019 Mar 9. Epub 2019 Mar 9.

From the Section of Legal Medicine, DIM, University of Bari, Bari, Italy.

Age estimation is a crucial matter in several forensic and legal instances. The literature recommends carrying out hand and wrist radiograph to assess skeletal age. Much research has been conducted to examine the application of various methods in different categories. Read More

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http://dx.doi.org/10.1097/PAF.0000000000000472DOI Listing

Clinical practice with sacubitril/valsartan: more on the Italian experience.

Authors:
Andrea Ungar

Curr Med Res Opin 2019 Mar;35(sup1):1-2

a Geriatric and Intensive Care Medicine , Careggi Hospital and University of Florence , Florence , Italy.

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http://dx.doi.org/10.1080/03007995.2019.1576483DOI Listing

Genotypic and phenotypic aspects of longevity: results from a Sicilian survey and implication for the prevention and the treatment of age-related diseases.

Curr Pharm Des 2019 Mar 12. Epub 2019 Mar 12.

Section of General Pathology, Department of Biomedicine, Neurosciences and Advanced Technologies - University of Palermo, Corso Tukory 211, 90134. Italy.

Background: It is well known that long living individuals are a model of successful ageing and that the identification of both genetic variants and environmental factors that predispose to long and health life is of tremendous interest for translational medicine.

Methods: We present the preliminary findings obtained from an ongoing study on longevity conducted on a sample of Sicilian long lived individuals.

Results: We review the characteristics of longevity in Sicily, taking into account life style, environment, genetics, hematochemical values, body composition and immunophenotype. Read More

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http://dx.doi.org/10.2174/1381612825666190313115233DOI Listing
March 2019
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