970 results match your criteria Italian Journal of Pediatrics [Journal]


Two novel mutations in exon 3 of PHOX2B gene: think about congenital central hypoventilation syndrome in patients with Hirschsprung disease.

Ital J Pediatr 2019 Apr 18;45(1):49. Epub 2019 Apr 18.

Respiratory Unit, Academic Department of Pediatrics, Bambino Gesù Children's Hospital, IRCCS, Piazza di Sant'Onofrio 4, 00165, Rome, Italy.

Background: Congenital central hypoventilation syndrome (CCHS) is characterized by alveolar hypoventilation increasing during sleep and affected patients are unable to perceive and respond to hypercarbia with increased ventilation and arousal during sleep. PHOX2B gene mutations are considered as responsible for CCHS. Most of patients with CCHS are heterozygous for polyalanine expansion mutations (PARMs) in exon 3, but 10% of patients with classic CCHS are heterozygous for non-polyalanine expansion mutations (NPARMs) of the PHOX2B gene. Read More

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http://dx.doi.org/10.1186/s13052-019-0636-8DOI Listing
April 2019
2 Reads

Nationwide survey of neonatal transportation practices in Italy.

Ital J Pediatr 2019 Apr 18;45(1):51. Epub 2019 Apr 18.

Neonatal Intensive Care Unit, Neonatal Emergency Transport Service, Department Mother&Child, IRCCS Istituto Giannina Gaslini, Largo G. Gaslini, 5, 16147, Genoa, Italy.

Background: Despite regionalization of perinatal care provides for the "in utero" transfer of high-risk pregnancies, there will always be a number of neonates who undergo acute inter-facility transport. The presence of a well-organized Neonatal Emergency Transport Service (NETS) can prevent and reduce risks of transportation, especially for very preterm infants, and is therefore mandatory for any program of regionalization of perinatal care. Italian National Health System is highly decentralized and Regions are autonomous to structure, plan and delivery their regional health services. Read More

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https://ijponline.biomedcentral.com/articles/10.1186/s13052-
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http://dx.doi.org/10.1186/s13052-019-0640-zDOI Listing
April 2019
1 Read

Prevalence, types, and malformations in congenital anomalies of the kidney and urinary tract in newborns: a retrospective hospital-based study.

Ital J Pediatr 2019 Apr 18;45(1):50. Epub 2019 Apr 18.

Department of Women's Health, Women's Hospital, Zhejiang University School of Medicine, No.1 Xueshi Road, Hangzhou, Zhejiang Province, 310006, People's Republic of China.

Background: Congenital anomalies of the kidney and urinary tract (CAKUTs) are some of the most common birth defects affecting newborns. CAKUTs often have poor birth outcomes owing to the limited experience of physicians in developing countries regarding antenatal and postnatal diagnosis. We aimed to estimate the epidemiology of CAKUTs using data from a hospital-based registry in Zhejiang Province, China. Read More

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http://dx.doi.org/10.1186/s13052-019-0635-9DOI Listing

Influenza vaccination: opinions of health care professionals working in pediatric emergency departments.

Ital J Pediatr 2019 Apr 11;45(1):47. Epub 2019 Apr 11.

Università degli Studi di Roma "La Sapienza" UOC di Pediatria e Neonatologia, Polo di Latina, Roma, Italy.

Background: Vaccine coverage of health care professionals against influenza is still low in Italy, as well as in other European countries.

Methods: Between March and May 2018, this study was performed to collect the opinions of Pediatric health care professionals, working in emergency departments, regarding the efficacy and safety of the influenza vaccine. An anonymous online survey was employed to evaluate socio-demographic and professional characteristics, knowledges, beliefs and attitudes. Read More

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http://dx.doi.org/10.1186/s13052-019-0638-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458720PMC

Factors associated with low birth weight among babies born at Hawassa University Comprehensive Specialized Hospital, Hawassa, Ethiopia.

Ital J Pediatr 2019 Apr 11;45(1):48. Epub 2019 Apr 11.

Department of Midwifery, College of Medicine and Health Science, Hawassa University, Hawassa, Ethiopia.

Background: Low birth weight is defined as infant born with weight of less than 2500 g. It is one of the major public health problems worldwide. In Ethiopia, there are limited evidences on factors contributing to low birthweight. Read More

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http://dx.doi.org/10.1186/s13052-019-0637-7DOI Listing
April 2019
1 Read

Treatment outcomes and factors affecting time-to-recovery from severe acute malnutrition in 6-59 months old children admitted to a stabilization center in Southern Ethiopia: A retrospective cohort study.

Ital J Pediatr 2019 Apr 11;45(1):46. Epub 2019 Apr 11.

St. Paul Hospital Millennium medical College, Addis Ababa, Ethiopia.

Background: Despite improving access to Severe Acute Malnutrition (SAM) management, information on the quality of the service, as measured by timely recovery, is scare. This study is designed to assess treatment outcomes and factors affecting time-to-recovery from SAM in children 6-59 months admitted to a stabilizing center in Hawassa University Comprehensive Specialized Hospital (HU-CSH), Southern Ethiopia.

Methods: Institutional-based retrospective cohort study was conducted on 420 randomly selected children aged 6-59 months. Read More

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http://dx.doi.org/10.1186/s13052-019-0642-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458656PMC
April 2019
1 Read

Preterm birth: seven-year retrospective study in a single centre population.

Ital J Pediatr 2019 Apr 11;45(1):45. Epub 2019 Apr 11.

Obstetrics and Gynecology Unit, Department of Human Pathology of Adult and Childhood "G. Barresi", University Hospital "G. Martino", via Consolare Valeria 1, Gazzi, Messina, Italy.

Background: Preterm birth is a health and social problem, considered the leading cause of neonatal mortality worldwide. It is associated with higher rates of neurodevelopmental morbidity, sensorineural impairments and other complications. The aim of the study was to describe the incidence and the major risk factors associated with preterm birth. Read More

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http://dx.doi.org/10.1186/s13052-019-0643-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458791PMC

Neonatal respiratory support strategies for the management of extremely low gestational age infants: an Italian survey.

Ital J Pediatr 2019 Apr 11;45(1):44. Epub 2019 Apr 11.

Department of Woman and Child Health and Public Health, Division of Neonatology, Fondazione Policlinico Universitario A. Gemelli IRCCS - Università Cattolica del Sacro Cuore, Rome, Italy.

Background: We aimed to survey Delivery Room and Neonatal Intensive Care Unit (NICU) respiratory strategies dedicated to the extremely low gestational age newborn (ELGAN - GA < 28 wks) in Italy.

Methods: A questionnaire was sent to 113 Italian level III centres. A lead physician and a nurse with expertise in mechanical ventilation (MV) were identified in each unit to answer. Read More

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http://dx.doi.org/10.1186/s13052-019-0639-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458627PMC
April 2019
1 Read

Ventricular bigeminy and trigeminy caused by hypophosphataemia during diabetic ketoacidosis treatment: a case report.

Ital J Pediatr 2019 Apr 2;45(1):42. Epub 2019 Apr 2.

Department of Pediatric Endocrinology and Diabetology, Medical University of Lublin, Lublin, Poland.

Background: Hypophosphatemia has many causes, and is often encountered during DKA (Diabetic Ketoacidosis) treatment. However, it rarely requires clinical intervention.

Case Presentation: Ventricular arrhythmia was observed in a 10-year-old girl with newly diagnosed type 1 diabetes mellitus and hypophosphatemia while undergoing treatment for ketoacidosis. Read More

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http://dx.doi.org/10.1186/s13052-019-0633-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444668PMC
April 2019
3 Reads

Vitamin D inhibits pro-inflammatory cytokines in the airways of cystic fibrosis patients infected by Pseudomonas aeruginosa- pilot study.

Ital J Pediatr 2019 Mar 29;45(1):41. Epub 2019 Mar 29.

Department of Pediatrics and Allergy, Medical University of Lodz, Copernicus Memorial Hospital, Korczak Paediatric Center, Piłsudskiego 71 Str, 90-329, Lodz, Poland.

Background: Vitamin D plays an important role in inflammatory responses after antigen exposure. Interleukin-23 (Il-23) promotes Il-17-dependent inflammation during Pseudomonas aeruginosa (P. aeruginosa) pulmonary infection. Read More

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http://dx.doi.org/10.1186/s13052-019-0634-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440129PMC
March 2019
2 Reads

The gliadin-CFTR connection: new perspectives for the treatment of celiac disease.

Ital J Pediatr 2019 Mar 21;45(1):40. Epub 2019 Mar 21.

Equipe11 labellisée Ligue Nationale contrele Cancer, Centre de Recherche des Cordeliers, Paris, France.

Familial loss-of-function mutations of the gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) channel protein cause cystic fibrosis (CF), the most frequent inherited life-threatening disease in the Caucasian population. A recent study indicates that the gluten/gliadin-derived peptide (P31-43) can cause CFTR inhibition in intestinal epithelial cells, thus causing a local stress response that contributes to the immunopathology of celiac disease (CD). Accordingly, an increased prevalence of CD has been observed in several cohorts of CF patients. Read More

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http://dx.doi.org/10.1186/s13052-019-0627-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429699PMC
March 2019
3 Reads

Long-term follow-up of newborns at neurological risk.

Ital J Pediatr 2019 Mar 18;45(1):38. Epub 2019 Mar 18.

Department of Pediatrics and Neonatology - Hospital of Jesi, Jesi, Italy.

Background: In order to give a new contribution to the knowledge of the psycho-physical, behavioral and socio-relational development of the individuals who were born at neurological risk, we have carried out a research work through a retrospective and observational analysis in such people, followed in their neuro-evolutionary development from the Department of Pediatrics and Neonatology of the Hospital of Jesi. The purpose of this work is to value the quality of life of the individuals born at neurological risk at a distance of time from the birth. In the literature only recently there are studies on the quality of life of some categories of people, but survey does not seem to be performed in individuals previously born at neurological risk. Read More

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http://dx.doi.org/10.1186/s13052-019-0629-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423827PMC

Medico-legal considerations on "Lotus Birth" in the Italian legislative framework.

Ital J Pediatr 2019 Mar 18;45(1):39. Epub 2019 Mar 18.

Fetal and Perinatal Pathology Unit, IRCCS Istituto Giannina Gaslini, Largo G. Gaslini, 16147, Genoa, Italy.

The term "Lotus Birth" identifies the practice of not cutting the umbilical cord and of leaving the placenta attached to the newborn after its expulsion until it detaches spontaneously, which generally occurs 3-10 days after birth. The first reported cases of Lotus Birth date back to 2004 in Australia.Supporters of such a procedure claim that the newborn is better perfused, endowed with a more robust immune system and "less stressed". Read More

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http://dx.doi.org/10.1186/s13052-019-0632-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423792PMC

An observational study of fixed-dose Tanacetum parthenium nutraceutical preparation for prophylaxis of pediatric headache.

Ital J Pediatr 2019 Mar 12;45(1):36. Epub 2019 Mar 12.

Child Neurology, Pediatric Headache & Sleep Disorders Centre, Chair of Pediatrics, NESMOS Department, Faculty of Medicine and Psychology, Sapienza University, Via Di Grottarossa, 1035-1039, 00189, Rome, Italy.

Background: Migraine is one of the most prevalent chronic pain manifestations of childhood. Despite the multitude of available treatments, parents are often concerned about chronic therapies and pediatricians have insufficient confidence in prescribing prophylactic drugs. Therefore, there is now growing interest for natural supplements used to control recurrent migraine headaches. Read More

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http://dx.doi.org/10.1186/s13052-019-0624-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419324PMC
March 2019
4 Reads
1.236 Impact Factor

Association of neural tube defects with maternal alterations and genetic polymorphisms in one-carbon metabolic pathway.

Ital J Pediatr 2019 Mar 14;45(1):37. Epub 2019 Mar 14.

Department of Pediatrics, Tianjin Children's Hospital, No.238 Longyan Road, Beichen District, Tianjin, 300134, China.

Background: Neural tube defects (NTDs) are birth defects of the brain, spine, or spinal cord invoked by the insufficient intake of folic acid in the early stages of pregnancy and have a complex etiology involving both genetic and environmental factors. So the study aimed to explore the association between alterations in maternal one-carbon metabolism and NTDs in the offspring.

Methods: We conducted a case-control study to get a deeper insight into this association, as well as into the role of genetic polymorphisms. Read More

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http://dx.doi.org/10.1186/s13052-019-0630-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416842PMC
March 2019
3 Reads

10-year experience with umbilical cord blood IgE and microbiome therapy.

Ital J Pediatr 2019 Mar 11;45(1):35. Epub 2019 Mar 11.

Department of Health Accounting and Statistics, University Hospital Pilsen, Pilsen, Czech Republic.

Background: The benefit of probiotics in newborn children in relation to allergy and general morbidity later in life appears to be controversial. Allergic diseases represent an increasingly important health problem worldwide in recent years. This is evident in all age groups. Read More

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https://ijponline.biomedcentral.com/articles/10.1186/s13052-
Publisher Site
http://dx.doi.org/10.1186/s13052-019-0620-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413446PMC
March 2019
5 Reads

Assessment of Preptin peptide level in the sera of rachitic children and in breast milk of their mothers.

Ital J Pediatr 2019 Mar 7;45(1):34. Epub 2019 Mar 7.

Minia General hospital, Minia, Egypt.

Background: Preptin is a 34-residue pancreatic hormone that stimulates osteoblast proliferation and reduces osteoblast apoptosis.

Research Aims: To measure levels of serum Preptin in rachitic children and in breastmilk of their mothers and to compare with levels in healthy non-rachitic children.

Methods: Thirty children with rickets and another 30 non-rachitic age and sex matched controls were subjected to detailed history, physical examination including anthropometric measurements, assessment of signs of rickets and laboratory measurement of serum vitamin D, calcium, phosphorus, alkaline phosphatase and Preptin. Read More

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http://dx.doi.org/10.1186/s13052-019-0628-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407189PMC
March 2019
1 Read

Why is "early childhood intensive care" an Italian association of neonatology study group?

Ital J Pediatr 2019 Mar 6;45(1):33. Epub 2019 Mar 6.

Neonatal and Pediatric Intensive Care Unit, Department of Human Pathology in Adult and Developmental Age "Gaetano Barresi", University of Messina, Via Consolare Valeria, 1, 98125, Messina, Italy.

To date, a large number of children are hospitalized inappropriately in adult intensive care units, where the minimum standards of care are not applied to young patients. It is well-known that the child is not a small adult. Recently it has been demonstrated that critically ill children hospitalized in pediatric intensive care receive higher quality of care, and have better outcomes, besides a lower mortality rate, compared to those admitted to adult intensive care units. Read More

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https://ijponline.biomedcentral.com/articles/10.1186/s13052-
Publisher Site
http://dx.doi.org/10.1186/s13052-019-0626-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404272PMC
March 2019
8 Reads

Combined effect of different factors on weight status and cardiometabolic risk in Italian adolescents.

Ital J Pediatr 2019 Mar 5;45(1):32. Epub 2019 Mar 5.

Sport and Exercise Sciences Research Unit, University of Palermo, Via G. Pascoli 6, 90144, Palermo, Italy.

Background: The observed increase in body weight and cardiometabolic risk (CR) in youth from developed countries contributes to the global burden of chronic diseases in adult age. The aim of this work is to provide a patterning of the associations between different factors and the weight status and CR of the subjects involved in the Italian ministerial ASSO project.

Methods: This study involved 919 students from high schools in Palermo. Read More

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https://ijponline.biomedcentral.com/articles/10.1186/s13052-
Publisher Site
http://dx.doi.org/10.1186/s13052-019-0619-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402148PMC
March 2019
7 Reads

Globalization of pediatric research: pharmacological RCTs in Latin America.

Ital J Pediatr 2019 Mar 4;45(1):29. Epub 2019 Mar 4.

Laboratory for Mother and Child Health, Department of Public Health, IRCCS - Istituto di RicercheFarmacologiche "Mario Negri", Via Giuseppe la Masa 19, 20156, Milan, Italy.

Globalization caused a shift in trial locations towards low-middle income countries, raising ethical concerns. These include the risk that conditions primarily affecting children in these countries will be neglected in favor of those affecting developed countries. We analyzed 253 published and 69 ongoing pharmacological RCTs performed in Latin America between 2000 and 2015 involving exclusively children. Read More

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http://dx.doi.org/10.1186/s13052-019-0622-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398244PMC

Consensus communication strategies to improve doctor-patient relationship in paediatric severe asthma.

Ital J Pediatr 2019 Mar 4;45(1):31. Epub 2019 Mar 4.

Department of Translational Medical Sciences, Federico II University, Naples, Italy.

Background: Asthma is a chronic inflammatory disease that is very common among youth worldwide. The burden of this illness is very high not only considering financial costs but also on emotional and social functioning. Guidelines and many researches recommend to develop a good communication between physicians and children/caregiver and their parents. Read More

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http://dx.doi.org/10.1186/s13052-019-0623-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399976PMC
March 2019
6 Reads
1.236 Impact Factor

Vitamin K deficiency bleeding in an apparently healthy newborn infant: the compelling need for evidence-based recommendation.

Ital J Pediatr 2019 Mar 4;45(1):30. Epub 2019 Mar 4.

Early infancy Sub-intensive Care Unit, Città della Salute e della Scienza di Torino, "Regina Margherita" Children's Hospital, Piazza Polonia, 94, 10126, Turin, Italy.

Background: Vitamin K is a key point for guarantee normal blood clotting and its level in newborns is commonly low, so a supplementation after delivery is mandatory. Vitamin K prophylaxis in newborns is still an open field of debate: many types of protocol have been proposed in different years and Countries, and sometimes with great variability inside the same Nation (for instance, in Italy a national consensus is not available, so different protocols are employed). Recommendations include different protocols for healthy newborns born at term, but the unpreventable presence of bleeding favouring factors (i. Read More

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http://dx.doi.org/10.1186/s13052-019-0625-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399912PMC
March 2019
5 Reads

Can we still do something-and what?-for a seemingly missing syndrome?

Ital J Pediatr 2019 Feb 28;45(1):28. Epub 2019 Feb 28.

Laboratory for Mother and Child Health, Department of Public Health, Istituto di Ricerche Farmacologiche Mario Negri-IRCCS, Via Giuseppe La Masa 19, 20156, Milan, Italy.

Background: Although several modifiable risk factors have been identified, and prone and side sleep positions were identified as preventing sudden infant death syndrome (SIDS), the epidemiology of sudden unexpected deaths in infancy (SUDI), which includes SIDS, has not unchanged in over a decade. What can be done?

Methods: Italian infant mortality rates were analysed between 1996 and 2015.

Results: Between 1996 and 2015 in Italy 1152 SUDI deaths were reported in infants less than one year old. Read More

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http://dx.doi.org/10.1186/s13052-019-0621-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394045PMC
February 2019

Not only Alagille syndrome. Syndromic paucity of interlobular bile ducts secondary to HNF1β deficiency: a case report and literature review.

Ital J Pediatr 2019 Feb 21;45(1):27. Epub 2019 Feb 21.

Pediatric Gastroenterology Unit, Regina Margherita Children's Hospital, Azienda Ospedaliero-Universitaria Città della Salute e della Scienza, University of Turin, Piazza Polonia 94, 10126, Turin, Italy.

Background: paucity of interlobular bile ducts is an important observation at liver biopsy in the diagnostic work-up of neonatal cholestasis. To date, other than in the Alagille syndrome, syndromic paucity of interlobular bile ducts has been documented in four cholestatic neonates with HFN1β mutations. A syndromic phenotype, known as renal cysts and diabetes syndrome (RCAD), has been identified. Read More

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http://dx.doi.org/10.1186/s13052-019-0617-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385394PMC
February 2019
1 Read

Italian translation, cultural adaptation, and pilot testing of a questionnaire to assess family burden in inherited ichthyoses.

Ital J Pediatr 2019 Feb 19;45(1):26. Epub 2019 Feb 19.

Department of Dermatology, Necker-Enfants Malades Hospital, Centre de Référence National pour les Maladies Génétiques à Expression Cutanée (MAGEC), APHP, Paris, France.

Background: Inherited ichthyoses are rare disorders characterized by generalized skin scaling. Among them, autosomal recessive congenital ichthyoses (ARCI) form a major subgroup presenting lifelong and severely disabling cutaneous and extracutaneous features and symptoms for which no curative treatment is available. Management relies on daily time-consuming and distressing topical medications. Read More

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https://ijponline.biomedcentral.com/articles/10.1186/s13052-
Publisher Site
http://dx.doi.org/10.1186/s13052-019-0618-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381706PMC
February 2019
11 Reads

Pediatric meningococcocal meningitis in the acute phase: how much does it cost?

Ital J Pediatr 2019 Feb 13;45(1):25. Epub 2019 Feb 13.

Pediatric and Infectious Disease Unit, Bambino Gesù Children Hospital, Rome, Italy.

Background: Meningococcal meningitis (MM) is known to be responsible of high cost for the Public Health Administration. Aim of the work is to calculate the costs for the hospitalization of pediatric patients affected by MM.

Methods: We calculate the costs for the hospitalization of pediatric patients affected by MM in the acute phase (HAP) over a nine year period. Read More

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http://dx.doi.org/10.1186/s13052-019-0616-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373101PMC
February 2019
2 Reads

Comparison of minor head trauma management in the emergency departments of a United States and Italian Children's hospital.

Ital J Pediatr 2019 Feb 11;45(1):24. Epub 2019 Feb 11.

Division of Emergency Medicine, Boston Children's Hospital, 300 Longwood Ave., Boston, MA, 02115, USA.

Background: Pediatric head trauma management varies between emergency departments globally. Here we aim to compare the pediatric minor head trauma management between a US and Italian hospital.

Methods: We conducted a retrospective chart review of children 0-18 years old presenting after minor head trauma (Glasgow Coma Scale 14-15) from two emergency departments, in Boston, Massachusetts, United States and Trieste, Italy, between January and December 2013. Read More

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http://dx.doi.org/10.1186/s13052-019-0615-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371605PMC
February 2019

SIADH versus adrenal insufficiency: a life-threatening misdiagnosis.

Ital J Pediatr 2019 Feb 6;45(1):23. Epub 2019 Feb 6.

University of Trieste, Piazzale Europa, 1, 34127, Trieste, Italy.

Background: Primary adrenal insufficiency (PAI) in children is an uncommon but severe condition which can be either inherited or acquired. It consists in clinical manifestation of defective production or ineffective action of endogenous glucocorticoids; deficiency in mineralocorticoids and adrenal androgens may coexist. Diagnosis of PAI in children and young people can be challenging; while adrenal crisis (acute decompensation) is a life-threatening condition, with patient presenting with characteristic features of hypoglycemia, hypotension, collapse and coma, chronic adrenal insufficiency may present with vague and non-specific symptoms, making the diagnosis more difficult. Read More

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http://dx.doi.org/10.1186/s13052-019-0614-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366080PMC
February 2019
11 Reads

The association of prenatal and postnatal macrolide exposure with subsequent development of infantile hypertrophic pyloric stenosis: a systematic review and meta-analysis.

Ital J Pediatr 2019 Feb 4;45(1):20. Epub 2019 Feb 4.

Department of Family and Community Medicine, College of Medicine, Taibah University, PO box 42317, Madinah, 41541, Saudi Arabia.

Background: The association between macrolides use and subsequent occurrence of infantile hypertrophic pyloric stenosis (IHPS) is still debatable. The aim of this study was to conduct a systematic review and meta-analysis of the association between perinatal exposure to macrolides, mainly erythromycin, and the development of pyloric stenosis.

Methods: Original studies were identified using MEDLINE, Web of Science, Scopus, Google Scholar, and the Cochrane Library databases. Read More

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http://dx.doi.org/10.1186/s13052-019-0613-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360705PMC
February 2019
1 Read

Correction to: Morphine-induced supraventricular tachycardia in near-term fetus.

Ital J Pediatr 2019 02 4;45(1):21. Epub 2019 Feb 4.

Division of Perinatal Medicine, Policlinico Abano Terme, Piazza Colombo 1, 35031, Abano Terme, Italy.

The original article [1] contained an error whereby all authors' names were mistakenly inverted. Read More

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http://dx.doi.org/10.1186/s13052-019-0612-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362584PMC
February 2019

Correction to: Evaluation of serum 25-Hydroxy vitamin D levels in children with autism Spectrum disorder.

Ital J Pediatr 2019 02 4;45(1):22. Epub 2019 Feb 4.

Social Determinant of Health Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

The original article [1] contained an error in author Mohammad Taghi Mansouri's name. Read More

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http://dx.doi.org/10.1186/s13052-019-0611-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362564PMC
February 2019
2 Reads
1.236 Impact Factor

Analysis of the predicting factors of recurrent wheezing in infants.

Ital J Pediatr 2019 Jan 29;45(1):19. Epub 2019 Jan 29.

The second department of respiration, Tianjin Children's Hospital, Tianjin, 300074, China.

Background: Clinically, asthma in children under 5 years old is under estimated because lack of diagnostic criteria. The current study was, therefore, designed to identify the predicting factors for recurrent wheezing in infants.

Methods: One hundred forty-five infants under 3-year old hospitalized with respiratory diseases were enrolled into this study. Read More

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http://dx.doi.org/10.1186/s13052-019-0609-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352350PMC
January 2019
1 Read

Effect of vitamin D3 seasonal supplementation with 1500 IU/day in north Italian children (DINOS study).

Ital J Pediatr 2019 Jan 28;45(1):18. Epub 2019 Jan 28.

Endocrinologist and General Practitioner Azienda ULSS 6 Euganea Regione Veneto, Studio via Benizzi 6, Padova, Italy.

Background: The appropriate dose of vitamin D supplementation in children is still debated. We calculated that the recommended dose of 600-1000 IU vitamin D3/day is not sufficient to reach a serum 25-hydroxyvitamin D (25-OH-D) level of at least 30 ng/ml (75 nmol/l) in north Italian children > 12 months. The aim of this study was to analyse the effect of seasonal supplementation with 1500 IU (=37. Read More

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http://dx.doi.org/10.1186/s13052-018-0590-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350345PMC
January 2019

Dynamic Ghrelin and GH serum levels during combined simultaneous arginine clonidine stimulation test in children with dwarfism.

Ital J Pediatr 2019 Jan 28;45(1):17. Epub 2019 Jan 28.

Jiangbin Hospital Affiliated to Jiangsu University, Zhenjiang, China.

Background: Combined simultaneous arginine clonidine stimulation (CSACS) test represents a more appropriate stimulus to detect Ghrelin, for it does not affect glucose metabolism.

Methods: Fifty prepubertal children with dwarfism were recruited and further classified into normal growth hormone (NGH) and growth hormone deficiency (GHD) group with growth hormone (GH) peak cut-off value of 10 μg/l. In both groups, GH and Ghrelin serum levels were determined after the GH provocation test at 30, 60, and 120 min and the height standard deviation score (SDS) for bone age was measured six months later. Read More

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http://dx.doi.org/10.1186/s13052-019-0610-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348616PMC
January 2019
1 Read

An association analysis to identify genetic variants linked to asthma and rhino-conjunctivitis in a cohort of Sicilian children.

Ital J Pediatr 2019 Jan 15;45(1):16. Epub 2019 Jan 15.

Dipartimento di Promozione della Salute, Materno-Infantile, di Medicina Interna e Specialistica di Eccellenza "G. D'Alessandro", University of Palermo, Palermo, Italy.

Asthma and rhino-conjunctivitis are common chronic diseases in childhood. In this cross-sectional study, we performed a gene association analysis with current asthma and rhino-conjunctivitis in a cohort of Sicilian children aged 10-15 years. Overall, our findings reveal the importance of different genetic variants at 4p14, 16p12. Read More

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https://ijponline.biomedcentral.com/articles/10.1186/s13052-
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http://dx.doi.org/10.1186/s13052-019-0603-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334451PMC
January 2019
10 Reads

Prelacteal feeding practice and its associated factors among mothers of children age less than 24 months old in Southern Ethiopia.

Ital J Pediatr 2019 Jan 15;45(1):15. Epub 2019 Jan 15.

School of Nursing and Midwifery, College of Health Science, Addis Ababa University, Addis Ababa, Ethiopia.

Background: Although Pre-lacteal feeding is a barrier for implementation of optimal breastfeeding practices and increases the risk of neonatal illness and mortality, still it is continued as a deep-rooted nutritional malpractice in developing countries. In Ethiopia pre-lacteal feeding continued as one of the nutritional malpractices in newborns. Therefore the aim of this study was to assess pre-lacteal feeding practice and its determinants among mothers of children less than 24 months of age in Sodo zuria district, Wolaita zone, Southern Ethiopia. Read More

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https://ijponline.biomedcentral.com/articles/10.1186/s13052-
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http://dx.doi.org/10.1186/s13052-019-0604-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334461PMC
January 2019
7 Reads

Malnutrition, morbidity and infection in the informal settlements of Nairobi, Kenya: an epidemiological study.

Ital J Pediatr 2019 Jan 14;45(1):12. Epub 2019 Jan 14.

Amici del Mondo - World Friends Onlus / Ruaraka Uhai Neema Hospital, P.O. Box 39433-00623, Nairobi, Kenya.

Background: Malnutrition constitutes one of the major public health challenges throughout the developing world. Urban poverty and malnutrition have been on the rise, with an increased rate of morbidity. We herein explore the relationship between infections and nutritional status and the related association with hygienic conditions as risk of infection in children residing in the slums of Nairobi. Read More

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http://dx.doi.org/10.1186/s13052-019-0607-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332593PMC
January 2019
3 Reads

Omalizumab in children with severe allergic disease: a case series.

Ital J Pediatr 2019 Jan 14;45(1):13. Epub 2019 Jan 14.

Department of Pediatrics, Allergy Unit, University of Messina, Via Consolare Valeria-Gazzi, 98124, Messina, Italy.

Background: Currently, severe allergic asthma and food allergy in children represent an important public health problem with medical, psychosocial and economic impacts. Omalizumab is a humanized monoclonal anti-IgE antibody, approved for refractory allergic asthma and chronic urticaria. It has been widely used in clinical practice as add-on therapy in patients with severe uncontrolled allergic asthma. Read More

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http://dx.doi.org/10.1186/s13052-019-0602-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332555PMC
January 2019
4 Reads
1.236 Impact Factor

The role of extracellular histones in systemic-onset juvenile idiopathic arthritis.

Ital J Pediatr 2019 Jan 14;45(1):14. Epub 2019 Jan 14.

Department of Rheumatology, Shanghai Children's Medical Center, Shanghai Jiaotong University, School of Medicine, Shanghai, 200127, China.

Background: To explore the effects of extracellular histones released by activated neutrophils on systemic-onset juvenile idiopathic arthritis (SoJIA), and to study the change of serum histone level between the active and remissive stage of SoJIA, then to clarify the role of serum histone in the pathogenesis of SoJIA.

Methods: Twenty-six patients with SoJIA were recruited, and clinical informations were collected, and the serum histone was detected by ELISA. While neutrophils from normal children were incubated with the serum from the patients with SoJIA, also including incubated with FeCL3 and histone, the extracellular histone was detected, respectively; heparin was added to the above-mentioned groups to observe the changes of extracellular histone levels. Read More

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http://dx.doi.org/10.1186/s13052-019-0605-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332604PMC
January 2019
2 Reads

Novel DNA variation of GPR54 gene in familial central precocious puberty.

Ital J Pediatr 2019 Jan 11;45(1):10. Epub 2019 Jan 11.

Medical Genetics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Background: Puberty can be considered the end point of a maturation process which is defined by the dynamic interactions of genes and environmental factors during prenatal and postnatal development. Kisspeptin/G protein-coupled receptor-54, is as an essential gatekeeper and regulator of GnRH neurons, and a key factor in initiation of puberty. Loss and gain of functional mutations in the GPR54 gene are associated with hypogonadotropic hypogonadism and precocious puberty, respectively. Read More

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https://ijponline.biomedcentral.com/articles/10.1186/s13052-
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http://dx.doi.org/10.1186/s13052-019-0601-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329138PMC
January 2019
9 Reads

Inequalities in infant mortality in Italy.

Ital J Pediatr 2019 Jan 11;45(1):11. Epub 2019 Jan 11.

Dipartimento di Pediatria, Università di Roma La Sapienza, Rome, Italy.

Background: All the children of the world should be born equal, but this is not so: even in Italy, there are striking differences already at birth. Neonatal and infant mortality are accurate indexes to assess the demographic wellbeing and quality of life of a population. The aim of the present study is to analyze the infant (IMR) and neonatal (NMR) mortality rates of Italian and foreign children and to evaluate if there is a disparity among geographical macro-areas. Read More

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https://ijponline.biomedcentral.com/articles/10.1186/s13052-
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http://dx.doi.org/10.1186/s13052-018-0594-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330401PMC
January 2019
8 Reads

Efficacy of the gluten free diet in the management of functional gastrointestinal disorders: a systematic review on behalf of the Italian Society of Paediatrics.

Ital J Pediatr 2019 Jan 11;45(1). Epub 2019 Jan 11.

Department of Translational Medical Sciences - Section of Paediatrics, University of Naples Federico II, via Pansini 5, 80131, Naples, Italy.

Background: Functional gastrointestinal disorders (FGIDs) are characterized by chronic/recurrent gastrointestinal symptoms not related to organic disorders. Due to the limited treatment options and to the perception of subjects with FGIDs suffering from a food intolerance, in recent years there has been an increase in the self-prescription of elimination diets, especially gluten free diet (GFD), for the treatment of these disorders. For this reason, we decided to perform this systematic review with the aim to evaluate the available evidence on the effects of a GFD on gastrointestinal symptoms, in subjects with FGIDs. Read More

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http://dx.doi.org/10.1186/s13052-019-0606-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329096PMC
January 2019
3 Reads

Stage 4 s neuroblastoma: features, management and outcome of 268 cases from the Italian Neuroblastoma Registry.

Ital J Pediatr 2019 Jan 11;45(1). Epub 2019 Jan 11.

Epidemiology and Biostatistics Unit, IRCCS Istituto Giannina Gaslini, Genoa, Italy.

Background: Infants diagnosed with stage 4 s neuroblastoma commonly experience spontaneous disease regression, with few succumbing without response to therapy. We analyzed a large cohort of such infants enrolled in the Italian Neuroblastoma Registry to detect changes over time in presenting features, treatment and outcome.

Methods: Of 3355 subjects aged 0-18 years with previously untreated neuroblastoma diagnosed between 1979 and 2013, a total of 280 infants (8. Read More

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https://ijponline.biomedcentral.com/articles/10.1186/s13052-
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http://dx.doi.org/10.1186/s13052-018-0599-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329141PMC
January 2019
28 Reads

Maternal HIV infection and preeclampsia increased risk of low birth weight among newborns delivered at University of Gondar specialized referral hospital, Northwest Ethiopia, 2017.

Ital J Pediatr 2019 Jan 10;45(1). Epub 2019 Jan 10.

Department of Community Health Nursing, School of Nursing, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.

Introduction: Globally, more than 20 million infants are born with low birth weight. The risk of neonatal mortality among low birth weight infants is 25 to 30 times greater than neonates with birth weight ≥ 2500 g. Low birth weight infants are at increased risk of infection, difficulty of feeding, and neurologic problems following birth. Read More

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https://ijponline.biomedcentral.com/articles/10.1186/s13052-
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http://dx.doi.org/10.1186/s13052-019-0608-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327374PMC
January 2019
11 Reads

The effects of position on gastric residual volume of premature infants in NICU.

Ital J Pediatr 2019 Jan 8;45(1). Epub 2019 Jan 8.

Clinical Research Development Center, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Background: Nutrition cares are of the main measures to save premature infants. In this regard, proper positioning is one of the key measures that is done by nurses; still there is a paucity of studies in this field and the results of these few studies are an area of ongoing debates. In light of this, the present paper is an attempt to determine the effects of different positioning on gastric residual volume in premature infants in NICU. Read More

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https://ijponline.biomedcentral.com/articles/10.1186/s13052-
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http://dx.doi.org/10.1186/s13052-018-0591-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323801PMC
January 2019
9 Reads
1.236 Impact Factor

Authors' reply - anaphylactic shock with methylprednisolone, Kounis syndrome and Hypersitivity to corticosteroids: a clinical paradox.

Ital J Pediatr 2019 01 7;45(1). Epub 2019 Jan 7.

Respiratory Unit, Academic Department of Pediatrics, Bambino Gesù Children's Hospital, IRCCS, Piazza di Sant'Onofrio 4, 00165, Rome, Italy.

In our letter, we comment the paper of Kounis et al., that highlights a poor-known clinical entity determined by systemic use of corticosteroids, the so-called "Kounis syndrome type I". We appreciated and shared the intent of Authors to treat the important issue of high risk of adverse drug reaction in patients with atopic diathesis and we confirm the need to administer corticosteroids with caution in patients suffering from allergic disease. Read More

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http://dx.doi.org/10.1186/s13052-018-0600-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323731PMC
January 2019
2 Reads
1.236 Impact Factor

Survival and predictors among preterm neonates admitted at University of Gondar comprehensive specialized hospital neonatal intensive care unit, Northwest Ethiopia.

Ital J Pediatr 2019 Jan 7;45(1). Epub 2019 Jan 7.

Department of Epidemiology and Biostatistics, Institute of Public Health, College of Medicine and Health Science, University of Gondar, Gondar, Ethiopia.

Background: Prematurity accounts about 1 million neonatal deaths worldwide and the second causes of both neonatal and under five-child mortality. Neonatal mortality accounts for 43% of under-five child mortality in Ethiopia. From this preterm is the second leading cause of death and is steadily increased in low-income countries. Read More

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https://ijponline.biomedcentral.com/articles/10.1186/s13052-
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http://dx.doi.org/10.1186/s13052-018-0597-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322326PMC
January 2019
4 Reads
1.236 Impact Factor

Hepatomegaly and type 1 diabetes: a clinical case of Mauriac's syndrome.

Ital J Pediatr 2019 Jan 7;45(1). Epub 2019 Jan 7.

Department of Human Pathology in Adult and Developmental Age "Gaetano Barresi", University of Messina, Via Consolare Valeria 1, 98125, Messina, Italy.

Background: Hepatic glycogenosis is characterized by excessive glycogen accumulation in hepatocytes and represents a complication of poor controlled type 1 diabetes. It can be caused by excessive insulin doses or recurrent ketoacidosis episodes. Mauriac's syndrome is a rare disease, which includes short stature, growth maturation delay, dyslipidemia, moon facies, protuberant abdomen, hepatomegaly with transaminase elevation. Read More

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http://dx.doi.org/10.1186/s13052-018-0598-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322227PMC
January 2019
1 Read

A modified physiologic test for bronchopulmonary dysplasia: a clinical tool for weaning from CPAP and/or oxygen-therapy the premature babies?

Ital J Pediatr 2019 Jan 4;45(1). Epub 2019 Jan 4.

Neonatal Intensive Care Unit, Department of Clinical Sciences and Community Health, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Università degli Studi di Milano, Milan, Italy.

Background: A physiologic test for estimating BPD rate has been developed by Walsh and collaborators. Actually there are not standard criteria for weaning from CPAP and/or oxygen therapy the premature babies. Aim of this study was to verify if a physiologic test, modified respect to that developed by Walsh and collaborators for estimating BPD rate, can be used as a clinical tool for weaning the premature babies from CPAP and/or oxygen therapy. Read More

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http://dx.doi.org/10.1186/s13052-018-0582-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320608PMC
January 2019
9 Reads

Postnatal length and weight growth velocities according to Fenton reference and their associated perinatal factors in healthy late preterm infants during birth to term-corrected age: an observational study.

Ital J Pediatr 2019 Jan 3;45(1). Epub 2019 Jan 3.

Department of Pediatrics, Shandong Provincial Hospital affiliated to Shandong University, 9677, Jingshi Road, Jinan, 250014, Shandong, China.

Background: Optimum early postnatal growth is critical for early and later health of preterm infants. Postnatal length and weight growth velocities and their associated perinatal factors in healthy late preterm infants without restriction of neonatal complications and nutritional problems have not been widely studied.

Methods: As part of ongoing longitudinal follow-up study of growth and development of preterm infants in Shandong Qianfoshan Hospital in China, 599 healthy late preterm infants without neonatal complications and nutritional problems were sampled from 795 preterm infants born in January 2014 to April 2017. Read More

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http://dx.doi.org/10.1186/s13052-018-0596-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318852PMC
January 2019
2 Reads
1.236 Impact Factor