946 results match your criteria Italian Journal of Pediatrics [Journal]


Italian translation, cultural adaptation, and pilot testing of a questionnaire to assess family burden in inherited ichthyoses.

Ital J Pediatr 2019 Feb 19;45(1):26. Epub 2019 Feb 19.

Department of Dermatology, Necker-Enfants Malades Hospital, Centre de Référence National pour les Maladies Génétiques à Expression Cutanée (MAGEC), APHP, Paris, France.

Background: Inherited ichthyoses are rare disorders characterized by generalized skin scaling. Among them, autosomal recessive congenital ichthyoses (ARCI) form a major subgroup presenting lifelong and severely disabling cutaneous and extracutaneous features and symptoms for which no curative treatment is available. Management relies on daily time-consuming and distressing topical medications. Read More

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https://ijponline.biomedcentral.com/articles/10.1186/s13052-
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http://dx.doi.org/10.1186/s13052-019-0618-xDOI Listing
February 2019
1 Read

Pediatric meningococcocal meningitis in the acute phase: how much does it cost?

Ital J Pediatr 2019 Feb 13;45(1):25. Epub 2019 Feb 13.

Pediatric and Infectious Disease Unit, Bambino Gesù Children Hospital, Rome, Italy.

Background: Meningococcal meningitis (MM) is known to be responsible of high cost for the Public Health Administration. Aim of the work is to calculate the costs for the hospitalization of pediatric patients affected by MM.

Methods: We calculate the costs for the hospitalization of pediatric patients affected by MM in the acute phase (HAP) over a nine year period. Read More

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http://dx.doi.org/10.1186/s13052-019-0616-zDOI Listing
February 2019

Comparison of minor head trauma management in the emergency departments of a United States and Italian Children's hospital.

Ital J Pediatr 2019 Feb 11;45(1):24. Epub 2019 Feb 11.

Division of Emergency Medicine, Boston Children's Hospital, 300 Longwood Ave., Boston, MA, 02115, USA.

Background: Pediatric head trauma management varies between emergency departments globally. Here we aim to compare the pediatric minor head trauma management between a US and Italian hospital.

Methods: We conducted a retrospective chart review of children 0-18 years old presenting after minor head trauma (Glasgow Coma Scale 14-15) from two emergency departments, in Boston, Massachusetts, United States and Trieste, Italy, between January and December 2013. Read More

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http://dx.doi.org/10.1186/s13052-019-0615-0DOI Listing
February 2019

SIADH versus adrenal insufficiency: a life-threatening misdiagnosis.

Ital J Pediatr 2019 Feb 6;45(1):23. Epub 2019 Feb 6.

University of Trieste, Piazzale Europa, 1, 34127, Trieste, Italy.

Background: Primary adrenal insufficiency (PAI) in children is an uncommon but severe condition which can be either inherited or acquired. It consists in clinical manifestation of defective production or ineffective action of endogenous glucocorticoids; deficiency in mineralocorticoids and adrenal androgens may coexist. Diagnosis of PAI in children and young people can be challenging; while adrenal crisis (acute decompensation) is a life-threatening condition, with patient presenting with characteristic features of hypoglycemia, hypotension, collapse and coma, chronic adrenal insufficiency may present with vague and non-specific symptoms, making the diagnosis more difficult. Read More

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http://dx.doi.org/10.1186/s13052-019-0614-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366080PMC
February 2019
2 Reads

The association of prenatal and postnatal macrolide exposure with subsequent development of infantile hypertrophic pyloric stenosis: a systematic review and meta-analysis.

Ital J Pediatr 2019 Feb 4;45(1):20. Epub 2019 Feb 4.

Department of Family and Community Medicine, College of Medicine, Taibah University, PO box 42317, Madinah, 41541, Saudi Arabia.

Background: The association between macrolides use and subsequent occurrence of infantile hypertrophic pyloric stenosis (IHPS) is still debatable. The aim of this study was to conduct a systematic review and meta-analysis of the association between perinatal exposure to macrolides, mainly erythromycin, and the development of pyloric stenosis.

Methods: Original studies were identified using MEDLINE, Web of Science, Scopus, Google Scholar, and the Cochrane Library databases. Read More

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http://dx.doi.org/10.1186/s13052-019-0613-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360705PMC
February 2019
1 Read

Correction to: Morphine-induced supraventricular tachycardia in near-term fetus.

Ital J Pediatr 2019 Feb 4;45(1):21. Epub 2019 Feb 4.

Division of Perinatal Medicine, Policlinico Abano Terme, Piazza Colombo 1, 35031, Abano Terme, Italy.

The original article [1] contained an error whereby all authors' names were mistakenly inverted. Read More

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http://dx.doi.org/10.1186/s13052-019-0612-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362584PMC
February 2019

Correction to: Evaluation of serum 25-Hydroxy vitamin D levels in children with autism Spectrum disorder.

Ital J Pediatr 2019 Feb 4;45(1):22. Epub 2019 Feb 4.

Social Determinant of Health Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

The original article [1] contained an error in author Mohammad Taghi Mansouri's name. Read More

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http://dx.doi.org/10.1186/s13052-019-0611-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362564PMC
February 2019
1 Read
1.236 Impact Factor

Analysis of the predicting factors of recurrent wheezing in infants.

Ital J Pediatr 2019 Jan 29;45(1):19. Epub 2019 Jan 29.

The second department of respiration, Tianjin Children's Hospital, Tianjin, 300074, China.

Background: Clinically, asthma in children under 5 years old is under estimated because lack of diagnostic criteria. The current study was, therefore, designed to identify the predicting factors for recurrent wheezing in infants.

Methods: One hundred forty-five infants under 3-year old hospitalized with respiratory diseases were enrolled into this study. Read More

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http://dx.doi.org/10.1186/s13052-019-0609-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352350PMC
January 2019

Effect of vitamin D3 seasonal supplementation with 1500 IU/day in north Italian children (DINOS study).

Ital J Pediatr 2019 Jan 28;45(1):18. Epub 2019 Jan 28.

Endocrinologist and General Practitioner Azienda ULSS 6 Euganea Regione Veneto, Studio via Benizzi 6, Padova, Italy.

Background: The appropriate dose of vitamin D supplementation in children is still debated. We calculated that the recommended dose of 600-1000 IU vitamin D3/day is not sufficient to reach a serum 25-hydroxyvitamin D (25-OH-D) level of at least 30 ng/ml (75 nmol/l) in north Italian children > 12 months. The aim of this study was to analyse the effect of seasonal supplementation with 1500 IU (=37. Read More

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http://dx.doi.org/10.1186/s13052-018-0590-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350345PMC
January 2019

Dynamic Ghrelin and GH serum levels during combined simultaneous arginine clonidine stimulation test in children with dwarfism.

Ital J Pediatr 2019 Jan 28;45(1):17. Epub 2019 Jan 28.

Jiangbin Hospital Affiliated to Jiangsu University, Zhenjiang, China.

Background: Combined simultaneous arginine clonidine stimulation (CSACS) test represents a more appropriate stimulus to detect Ghrelin, for it does not affect glucose metabolism.

Methods: Fifty prepubertal children with dwarfism were recruited and further classified into normal growth hormone (NGH) and growth hormone deficiency (GHD) group with growth hormone (GH) peak cut-off value of 10 μg/l. In both groups, GH and Ghrelin serum levels were determined after the GH provocation test at 30, 60, and 120 min and the height standard deviation score (SDS) for bone age was measured six months later. Read More

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http://dx.doi.org/10.1186/s13052-019-0610-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348616PMC
January 2019

An association analysis to identify genetic variants linked to asthma and rhino-conjunctivitis in a cohort of Sicilian children.

Ital J Pediatr 2019 Jan 15;45(1):16. Epub 2019 Jan 15.

Dipartimento di Promozione della Salute, Materno-Infantile, di Medicina Interna e Specialistica di Eccellenza "G. D'Alessandro", University of Palermo, Palermo, Italy.

Asthma and rhino-conjunctivitis are common chronic diseases in childhood. In this cross-sectional study, we performed a gene association analysis with current asthma and rhino-conjunctivitis in a cohort of Sicilian children aged 10-15 years. Overall, our findings reveal the importance of different genetic variants at 4p14, 16p12. Read More

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https://ijponline.biomedcentral.com/articles/10.1186/s13052-
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http://dx.doi.org/10.1186/s13052-019-0603-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334451PMC
January 2019
4 Reads

Prelacteal feeding practice and its associated factors among mothers of children age less than 24 months old in Southern Ethiopia.

Ital J Pediatr 2019 Jan 15;45(1):15. Epub 2019 Jan 15.

School of Nursing and Midwifery, College of Health Science, Addis Ababa University, Addis Ababa, Ethiopia.

Background: Although Pre-lacteal feeding is a barrier for implementation of optimal breastfeeding practices and increases the risk of neonatal illness and mortality, still it is continued as a deep-rooted nutritional malpractice in developing countries. In Ethiopia pre-lacteal feeding continued as one of the nutritional malpractices in newborns. Therefore the aim of this study was to assess pre-lacteal feeding practice and its determinants among mothers of children less than 24 months of age in Sodo zuria district, Wolaita zone, Southern Ethiopia. Read More

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https://ijponline.biomedcentral.com/articles/10.1186/s13052-
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http://dx.doi.org/10.1186/s13052-019-0604-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334461PMC
January 2019
2 Reads

Malnutrition, morbidity and infection in the informal settlements of Nairobi, Kenya: an epidemiological study.

Ital J Pediatr 2019 Jan 14;45(1):12. Epub 2019 Jan 14.

Amici del Mondo - World Friends Onlus / Ruaraka Uhai Neema Hospital, P.O. Box 39433-00623, Nairobi, Kenya.

Background: Malnutrition constitutes one of the major public health challenges throughout the developing world. Urban poverty and malnutrition have been on the rise, with an increased rate of morbidity. We herein explore the relationship between infections and nutritional status and the related association with hygienic conditions as risk of infection in children residing in the slums of Nairobi. Read More

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http://dx.doi.org/10.1186/s13052-019-0607-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332593PMC
January 2019
2 Reads

Omalizumab in children with severe allergic disease: a case series.

Ital J Pediatr 2019 Jan 14;45(1):13. Epub 2019 Jan 14.

Department of Pediatrics, Allergy Unit, University of Messina, Via Consolare Valeria-Gazzi, 98124, Messina, Italy.

Background: Currently, severe allergic asthma and food allergy in children represent an important public health problem with medical, psychosocial and economic impacts. Omalizumab is a humanized monoclonal anti-IgE antibody, approved for refractory allergic asthma and chronic urticaria. It has been widely used in clinical practice as add-on therapy in patients with severe uncontrolled allergic asthma. Read More

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http://dx.doi.org/10.1186/s13052-019-0602-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332555PMC
January 2019
2 Reads
1.236 Impact Factor

The role of extracellular histones in systemic-onset juvenile idiopathic arthritis.

Ital J Pediatr 2019 Jan 14;45(1):14. Epub 2019 Jan 14.

Department of Rheumatology, Shanghai Children's Medical Center, Shanghai Jiaotong University, School of Medicine, Shanghai, 200127, China.

Background: To explore the effects of extracellular histones released by activated neutrophils on systemic-onset juvenile idiopathic arthritis (SoJIA), and to study the change of serum histone level between the active and remissive stage of SoJIA, then to clarify the role of serum histone in the pathogenesis of SoJIA.

Methods: Twenty-six patients with SoJIA were recruited, and clinical informations were collected, and the serum histone was detected by ELISA. While neutrophils from normal children were incubated with the serum from the patients with SoJIA, also including incubated with FeCL3 and histone, the extracellular histone was detected, respectively; heparin was added to the above-mentioned groups to observe the changes of extracellular histone levels. Read More

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http://dx.doi.org/10.1186/s13052-019-0605-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332604PMC
January 2019
1 Read

Novel DNA variation of GPR54 gene in familial central precocious puberty.

Ital J Pediatr 2019 Jan 11;45(1):10. Epub 2019 Jan 11.

Medical Genetics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Background: Puberty can be considered the end point of a maturation process which is defined by the dynamic interactions of genes and environmental factors during prenatal and postnatal development. Kisspeptin/G protein-coupled receptor-54, is as an essential gatekeeper and regulator of GnRH neurons, and a key factor in initiation of puberty. Loss and gain of functional mutations in the GPR54 gene are associated with hypogonadotropic hypogonadism and precocious puberty, respectively. Read More

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https://ijponline.biomedcentral.com/articles/10.1186/s13052-
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http://dx.doi.org/10.1186/s13052-019-0601-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329138PMC
January 2019
6 Reads

Inequalities in infant mortality in Italy.

Ital J Pediatr 2019 Jan 11;45(1):11. Epub 2019 Jan 11.

Dipartimento di Pediatria, Università di Roma La Sapienza, Rome, Italy.

Background: All the children of the world should be born equal, but this is not so: even in Italy, there are striking differences already at birth. Neonatal and infant mortality are accurate indexes to assess the demographic wellbeing and quality of life of a population. The aim of the present study is to analyze the infant (IMR) and neonatal (NMR) mortality rates of Italian and foreign children and to evaluate if there is a disparity among geographical macro-areas. Read More

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https://ijponline.biomedcentral.com/articles/10.1186/s13052-
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http://dx.doi.org/10.1186/s13052-018-0594-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330401PMC
January 2019
3 Reads

Efficacy of the gluten free diet in the management of functional gastrointestinal disorders: a systematic review on behalf of the Italian Society of Paediatrics.

Ital J Pediatr 2019 Jan 11;45(1). Epub 2019 Jan 11.

Department of Translational Medical Sciences - Section of Paediatrics, University of Naples Federico II, via Pansini 5, 80131, Naples, Italy.

Background: Functional gastrointestinal disorders (FGIDs) are characterized by chronic/recurrent gastrointestinal symptoms not related to organic disorders. Due to the limited treatment options and to the perception of subjects with FGIDs suffering from a food intolerance, in recent years there has been an increase in the self-prescription of elimination diets, especially gluten free diet (GFD), for the treatment of these disorders. For this reason, we decided to perform this systematic review with the aim to evaluate the available evidence on the effects of a GFD on gastrointestinal symptoms, in subjects with FGIDs. Read More

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http://dx.doi.org/10.1186/s13052-019-0606-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329096PMC
January 2019
2 Reads

Stage 4 s neuroblastoma: features, management and outcome of 268 cases from the Italian Neuroblastoma Registry.

Ital J Pediatr 2019 Jan 11;45(1). Epub 2019 Jan 11.

Epidemiology and Biostatistics Unit, IRCCS Istituto Giannina Gaslini, Genoa, Italy.

Background: Infants diagnosed with stage 4 s neuroblastoma commonly experience spontaneous disease regression, with few succumbing without response to therapy. We analyzed a large cohort of such infants enrolled in the Italian Neuroblastoma Registry to detect changes over time in presenting features, treatment and outcome.

Methods: Of 3355 subjects aged 0-18 years with previously untreated neuroblastoma diagnosed between 1979 and 2013, a total of 280 infants (8. Read More

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https://ijponline.biomedcentral.com/articles/10.1186/s13052-
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http://dx.doi.org/10.1186/s13052-018-0599-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329141PMC
January 2019
16 Reads

Maternal HIV infection and preeclampsia increased risk of low birth weight among newborns delivered at University of Gondar specialized referral hospital, Northwest Ethiopia, 2017.

Ital J Pediatr 2019 Jan 10;45(1). Epub 2019 Jan 10.

Department of Community Health Nursing, School of Nursing, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.

Introduction: Globally, more than 20 million infants are born with low birth weight. The risk of neonatal mortality among low birth weight infants is 25 to 30 times greater than neonates with birth weight ≥ 2500 g. Low birth weight infants are at increased risk of infection, difficulty of feeding, and neurologic problems following birth. Read More

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https://ijponline.biomedcentral.com/articles/10.1186/s13052-
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http://dx.doi.org/10.1186/s13052-019-0608-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327374PMC
January 2019
5 Reads

The effects of position on gastric residual volume of premature infants in NICU.

Ital J Pediatr 2019 Jan 8;45(1). Epub 2019 Jan 8.

Clinical Research Development Center, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Background: Nutrition cares are of the main measures to save premature infants. In this regard, proper positioning is one of the key measures that is done by nurses; still there is a paucity of studies in this field and the results of these few studies are an area of ongoing debates. In light of this, the present paper is an attempt to determine the effects of different positioning on gastric residual volume in premature infants in NICU. Read More

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https://ijponline.biomedcentral.com/articles/10.1186/s13052-
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http://dx.doi.org/10.1186/s13052-018-0591-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323801PMC
January 2019
6 Reads
1.236 Impact Factor

Authors' reply - anaphylactic shock with methylprednisolone, Kounis syndrome and Hypersitivity to corticosteroids: a clinical paradox.

Ital J Pediatr 2019 Jan 7;45(1). Epub 2019 Jan 7.

Respiratory Unit, Academic Department of Pediatrics, Bambino Gesù Children's Hospital, IRCCS, Piazza di Sant'Onofrio 4, 00165, Rome, Italy.

In our letter, we comment the paper of Kounis et al., that highlights a poor-known clinical entity determined by systemic use of corticosteroids, the so-called "Kounis syndrome type I". We appreciated and shared the intent of Authors to treat the important issue of high risk of adverse drug reaction in patients with atopic diathesis and we confirm the need to administer corticosteroids with caution in patients suffering from allergic disease. Read More

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http://dx.doi.org/10.1186/s13052-018-0600-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323731PMC
January 2019
1.236 Impact Factor

Survival and predictors among preterm neonates admitted at University of Gondar comprehensive specialized hospital neonatal intensive care unit, Northwest Ethiopia.

Ital J Pediatr 2019 Jan 7;45(1). Epub 2019 Jan 7.

Department of Epidemiology and Biostatistics, Institute of Public Health, College of Medicine and Health Science, University of Gondar, Gondar, Ethiopia.

Background: Prematurity accounts about 1 million neonatal deaths worldwide and the second causes of both neonatal and under five-child mortality. Neonatal mortality accounts for 43% of under-five child mortality in Ethiopia. From this preterm is the second leading cause of death and is steadily increased in low-income countries. Read More

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https://ijponline.biomedcentral.com/articles/10.1186/s13052-
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http://dx.doi.org/10.1186/s13052-018-0597-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322326PMC
January 2019
3 Reads
1.236 Impact Factor

Hepatomegaly and type 1 diabetes: a clinical case of Mauriac's syndrome.

Ital J Pediatr 2019 Jan 7;45(1). Epub 2019 Jan 7.

Department of Human Pathology in Adult and Developmental Age "Gaetano Barresi", University of Messina, Via Consolare Valeria 1, 98125, Messina, Italy.

Background: Hepatic glycogenosis is characterized by excessive glycogen accumulation in hepatocytes and represents a complication of poor controlled type 1 diabetes. It can be caused by excessive insulin doses or recurrent ketoacidosis episodes. Mauriac's syndrome is a rare disease, which includes short stature, growth maturation delay, dyslipidemia, moon facies, protuberant abdomen, hepatomegaly with transaminase elevation. Read More

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http://dx.doi.org/10.1186/s13052-018-0598-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322227PMC
January 2019

A modified physiologic test for bronchopulmonary dysplasia: a clinical tool for weaning from CPAP and/or oxygen-therapy the premature babies?

Ital J Pediatr 2019 Jan 4;45(1). Epub 2019 Jan 4.

Neonatal Intensive Care Unit, Department of Clinical Sciences and Community Health, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Università degli Studi di Milano, Milan, Italy.

Background: A physiologic test for estimating BPD rate has been developed by Walsh and collaborators. Actually there are not standard criteria for weaning from CPAP and/or oxygen therapy the premature babies. Aim of this study was to verify if a physiologic test, modified respect to that developed by Walsh and collaborators for estimating BPD rate, can be used as a clinical tool for weaning the premature babies from CPAP and/or oxygen therapy. Read More

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http://dx.doi.org/10.1186/s13052-018-0582-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320608PMC
January 2019
1 Read

Postnatal length and weight growth velocities according to Fenton reference and their associated perinatal factors in healthy late preterm infants during birth to term-corrected age: an observational study.

Ital J Pediatr 2019 Jan 3;45(1). Epub 2019 Jan 3.

Department of Pediatrics, Shandong Provincial Hospital affiliated to Shandong University, 9677, Jingshi Road, Jinan, 250014, Shandong, China.

Background: Optimum early postnatal growth is critical for early and later health of preterm infants. Postnatal length and weight growth velocities and their associated perinatal factors in healthy late preterm infants without restriction of neonatal complications and nutritional problems have not been widely studied.

Methods: As part of ongoing longitudinal follow-up study of growth and development of preterm infants in Shandong Qianfoshan Hospital in China, 599 healthy late preterm infants without neonatal complications and nutritional problems were sampled from 795 preterm infants born in January 2014 to April 2017. Read More

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http://dx.doi.org/10.1186/s13052-018-0596-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318852PMC
January 2019
1 Read
1.236 Impact Factor

Listeria monocytogenes meningitis in immunocompetent and healthy children: a case report and a review of the literature.

Ital J Pediatr 2018 Dec 29;44(1):152. Epub 2018 Dec 29.

Pediatric Highly Intensive Care Unit, Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.

Background: Listeria monocytogenes is a gram-positive bacteria generally transmitted to humans through ingestion of contaminated food. It typically infects high risk subjects, such as pregnant women, neonates, the elderly and immunocompromised patients. Listeria meningitis is rarely reported in previously healthy children with no immunological disorders. Read More

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http://dx.doi.org/10.1186/s13052-018-0595-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311039PMC
December 2018

Is preterm birth associated with asthma among children from birth to 17 years old? -A study based on 2011-2012 US National Survey of Children's Health.

Ital J Pediatr 2018 Dec 22;44(1):151. Epub 2018 Dec 22.

Department of Ship Hygiene, Faculty of Naval Medicine, Second Military Medical University, Shanghai, 200433, China.

Background: Preterm birth can interrupt lung development in utero and is associated with early life factors, which adversely affects the developing respiratory system. Studies on preterm birth and asthma risk are comparatively sparse and the results are not consistent.

Methods: Multivariate analyses were performed on a cross-sectional data from the National Survey of Children's Health (NSCH) collected in 2011 to 2012. Read More

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http://dx.doi.org/10.1186/s13052-018-0583-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303925PMC
December 2018

Evaluation of serum 25-Hydroxy vitamin D levels in children with autism Spectrum disorder.

Ital J Pediatr 2018 Dec 17;44(1):150. Epub 2018 Dec 17.

Social Determinant of Health Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Background: Vitamin D plays an important role in etiology of Autism Spectrum Disorders (ASDs). We aimed to evaluate the serum 25 - hydroxyl vitamin D level among children with ASDs in Ahvaz city, Iran.

Methods: It was a cross-sectional study which had conducted on 62 subjects in two groups: a case group (n = 31) consisted of ASD children who study in especial schools; and a control group (n = 31) of healthy children who were selected by simple random sampling from regular schools in Ahvaz city, Iran during 2016. Read More

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http://dx.doi.org/10.1186/s13052-018-0587-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6296143PMC
December 2018
1 Read
1.236 Impact Factor

Re-comparing of three different epidemic seasons of bronchiolitis: different prophylaxis approaches.

Ital J Pediatr 2018 Dec 12;44(1):148. Epub 2018 Dec 12.

Neonatology-NICU Casilino General Hospital, via Casilina 1049, 00169, Rome, Italy.

During the last epidemic season of bronchiolitis (S2, years 2016-2017) we performed a single Centre analysis in inborn infant of 30-32 gestational age and age < 12 months who did not receive prophylaxis with palivizumab (PLV), in light of the current AIFA (Italian Drug Agency) guidelines restricting the time of the prophylaxis to those born < 30 weeks of gestational age. During that epidemic season, we observed a rising trend of bronchiolitis-related hospitalization and an increased rate of mechanical ventilation in preterm child compared to the previous one (S1, years 2015-2016) during which infants of this same gestational age received palivizumab (PLV) prophylaxis, according to the 2015 Italian Guidelines.In light of the revised AIFA guidelines (November 2017), allowing once again prophylaxis with PLV in infants of > 30 weeks gestational age, we decided to repeat our observation during the last epidemic season (S3, years 2017-2018), in order to compare ours infants of 30-32 gestational age with preterm of the same gestational age born in our unit in the previous seasons (S1 and S2), to evaluate the clinical impact of the different prophylaxis approaches. Read More

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http://dx.doi.org/10.1186/s13052-018-0593-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292081PMC
December 2018

SIAIP position paper: provocation challenge to antibiotics and non-steroidal anti-inflammatory drugs in children.

Ital J Pediatr 2018 Dec 7;44(1):147. Epub 2018 Dec 7.

Pediatric Unit, Infant Maternal Department, Azienda Sanitaria Provinciale Crotone, Crotone, Italy.

Drug hypersensitivity reactions (DHRs) in childhood are mainly caused by betalactam or non-betalactam antibiotics, and non-steroidal anti-inflammatory drugs (NSAIDs). Laboratory tests for identifying children who are allergic to drugs have low diagnostic accuracy and predictive value. The gold standard to diagnose DHR is represented by the drug provocation test (DPT), that aims of ascertaining the causative role of an allergen and evaluating the tolerance to the suspected drug. Read More

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http://dx.doi.org/10.1186/s13052-018-0589-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286516PMC
December 2018
1 Read

Gambling disorder in adolescents: what do we know about this social problem and its consequences?

Ital J Pediatr 2018 Dec 4;44(1):146. Epub 2018 Dec 4.

Institute of Pediatrics, University of Palermo, Palermo, Italy.

Gambling disorder (GD) is a psychiatric condition and it is characterized by a maladaptive pattern of gambling behavior that persists despite negative consequences in major areas of life functioning. In Italy, CNR (National Research Council) underlined how over 17 million, 42.8% of the population aged 15-64 have a gambling behavior. Read More

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https://ijponline.biomedcentral.com/articles/10.1186/s13052-
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http://dx.doi.org/10.1186/s13052-018-0592-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280468PMC
December 2018
7 Reads

Genomics of neonatal sepsis: has-miR-150 targeting BCL11B functions in disease progression.

Ital J Pediatr 2018 Nov 29;44(1):145. Epub 2018 Nov 29.

Pediatric Department, Zhongda Hospital of Southeast University, 210009, Nanjing, People's Republic of China.

Background: Neonatal sepsis is an inflammatory systemic syndrome, which is a major cause of morbidity and mortality in premature infants. We analyzed the expression profile data of E-MTAB-4785 to reveal the pathogenesis of the disease.

Methods: The expression profile dataset E-MTAB-4785, which contained 17 sepsis samples and 19 normal samples, was obtained from the ArrayExpress database. Read More

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http://dx.doi.org/10.1186/s13052-018-0575-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267077PMC
November 2018
6 Reads

Anaphylactic shock with methylprednisolone, Kounis syndrome and hypersensitivity to corticosteroids: a clinical paradox.

Ital J Pediatr 2018 Nov 28;44(1):143. Epub 2018 Nov 28.

Krankenhaus der Barmherzigen Brüder, Trier, Germany.

Corticosteroids are widely used for the treatment of allergic reactions but paradoxically themselves may induce acute, delayed, local or systemic allergic reactions and even anaphylaxis with Kounis syndrome. They can suppress the release of arachidonic acid from mast cell membranes, via phospholipase A2 and eicosanoid biosynthesis inhibition. Corticosteroids can promote cell apoptosis and mediate in annexin or lipocortin synthesis, substances that modulate inflammatory cell activation, adhesion molecule expression, transmigratory and phagocytic functions. Read More

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http://dx.doi.org/10.1186/s13052-018-0579-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6263969PMC
November 2018
4 Reads

Off-label drugs use in pediatric palliative care.

Ital J Pediatr 2018 Nov 29;44(1):144. Epub 2018 Nov 29.

Paediatric Palliative Care - Pain Service, Department of Women's Children's Health, University of Padua, Padova, Italy.

Background: Paediatric palliative care (PPC) aim to ensure the control of symptoms and the best possible quality of life for patients whose underlying disease, characterized by an unstoppable evolution and negative prognosis, no longer responds to specific treatments. The scientific evidence in this context are very deficient and, in order to obtain welfare objectives consistent with the situation, in the overwhelming majority of cases the prescription of drugs is off-label for indication of use and/or for age and/or for way of administration and/or formulation. The Agenzia Italiana del Farmaco - AIFA and the Italian Society of Palliative Care (Società Italiana di Cure Palliative - SICP), under a dedicated working group, wrote a document that collects the scientific evidence available to support the off-label use of medicines more frequently used in PPC. Read More

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http://dx.doi.org/10.1186/s13052-018-0584-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264039PMC
November 2018
1 Read

Perception of childhood anaemia among mothers in Kumasi: a quantitative approach.

Ital J Pediatr 2018 Nov 26;44(1):142. Epub 2018 Nov 26.

University for Development Studies, Tamale, Ghana.

Background: Anaemia is the world's second cause of disability and it affects over half of pre-school children in developing countries and at least 30-40% in industrial countries. In poorer malaria-endemic countries, anemia is one of the commonest preventable causes of death in children under 5 years. This study sought to determine the perceived causes, signs and symptoms as well prevention of childhood anaemia among mothers of children under 5 years in Kumasi, Ghana. Read More

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http://dx.doi.org/10.1186/s13052-018-0588-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258271PMC
November 2018
1 Read
1.236 Impact Factor

Low birth weight and its associated factors in Ethiopia: a systematic review and meta-analysis.

Ital J Pediatr 2018 Nov 26;44(1):141. Epub 2018 Nov 26.

Department of Environmental and Occupational Health and Safety, Institute of Public Health, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.

Background: Different primary studies in Ethiopia showed the burden of low birth weight. However, variation among those studies was seen. This study was aimed to estimate the national prevalence and associated factors of low birth weight in Ethiopia. Read More

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http://dx.doi.org/10.1186/s13052-018-0586-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258299PMC
November 2018
22 Reads
1.236 Impact Factor

An early diagnosis of trichorhinophalangeal syndrome type 1: a case report and a review of literature.

Ital J Pediatr 2018 Nov 20;44(1):138. Epub 2018 Nov 20.

Division of Pediatric Endocrinology, Meyer University Children's Hospital, University of Florence, Florence, Italy.

Background: Trichorhinophalangeal syndrome (TRPS) is a rare autosomal dominant disorder caused by defects involving the TRPS1 gene. It exhibits distinctive craniofacial, ectodermal and skeletal abnormalities, such as sparse hair, bulbous nasal tip and short deformed fingers, with extremely variable expressivity.

Case Presentation: We report the case of a 17 months old girl, who presented growth retardation and dysmorphic features. Read More

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http://dx.doi.org/10.1186/s13052-018-0580-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245908PMC
November 2018
2 Reads

Hospital clinical pathways for children affected by juvenile idiopathic arthritis.

Ital J Pediatr 2018 Nov 20;44(1):139. Epub 2018 Nov 20.

Department of Biomedical Sciences for Health, University of Milan, Milan, Italy.

Background: Juvenile idiopathic arthritis (JIA) is the most common pediatric chronic rheumatic disease, which requires constant follow-up over the years, due to relapses during its progression. To maintain a good quality of life, it is important to limit admissions as far as possible. With the development of a Diagnostic Therapeutic Assistance Pathway (DTAP), we aim to select patients with suitable clinical conditions to be moved from routine hospital management to day care or outpatient treatment, evaluating the number of patients to whom this would apply. Read More

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http://dx.doi.org/10.1186/s13052-018-0576-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245695PMC
November 2018
10 Reads

West-Nile virus encephalitis in an immunocompetent pediatric patient: successful recovery.

Ital J Pediatr 2018 Nov 20;44(1):140. Epub 2018 Nov 20.

Molecular Virology Unit, Microbiology and Virology Department, Fondazione IRCCS Policlinico San Matteo, 27100, Pavia, Italy.

Background: West Nile virus (WNV) is a mosquito-borne RNA virus belonging to the Flaviviridae family. Symptomatic infection happens in only about 20% of the cases, while WNV neuroinvasive disease (WNND) is rare and accounts for less than 1%. There is insufficient information about natural history and clinical course in children, because underdiagnosis is common, and reports are scarce. Read More

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http://dx.doi.org/10.1186/s13052-018-0574-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245891PMC
November 2018
8 Reads

Differentiating Kawasaki disease from urinary tract infection in febrile children with pyuria and C-reactive protein elevation.

Ital J Pediatr 2018 Nov 20;44(1):137. Epub 2018 Nov 20.

Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

Background: Kawasaki disease (KD) is sometimes confused with urinary tract infection (UTI) because both can present with pyuria and C-reactive protein (CRP) elevation. The present study investigated the clinical and laboratory findings that can differentiate KD from UTI in febrile children with pyuria and CRP elevation.

Methods: Medical records were retrospectively reviewed for children with KD and those with UTI. Read More

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http://dx.doi.org/10.1186/s13052-018-0585-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245823PMC
November 2018

Phenotypic testicular abnormalities and pubertal development in boys with McCune-Albright syndrome.

Ital J Pediatr 2018 Nov 19;44(1):136. Epub 2018 Nov 19.

Department of Human Pathology in Adulthood and Childhood, University of Messina, Via Consolare Valeria, 98124, Messina, Italy.

Aim of this survey is to review the few available literature data on pathophysiologic and clinical aspects of pubertal development in boys with McCune-Albright syndrome (MAS). On the basis of such analysis, we concluded that:1) peripheral precocious puberty (PPP) is significantly more infrequent in boys than in girls; 2) the most common testicular abnormality at MAS presentation is macroorchidism, that may be either monolateral or bilateral; 3) macroorchidism is not always associated with clinical and biochemical evidence of PPP; 4) testicular microlothiasis is distinctly more frequent in boys with MAS than in those without MAS; 5) the available therapeutic schedules have to be adopted already at MAS presentation only in the cases with PPP. Read More

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http://dx.doi.org/10.1186/s13052-018-0577-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245937PMC
November 2018
1 Read

New treatments for the mucopolysaccharidoses: from pathophysiology to therapy.

Ital J Pediatr 2018 Nov 16;44(Suppl 2):124. Epub 2018 Nov 16.

Department of Translational Medical Sciences, Federico II University, Naples, Italy.

Enzyme replacement therapy is currently considered the standard of care for the treatment of mucopolysaccharidoses (MPS) type I, II, VI, and IV. This approach has shown substantial efficacy mainly on somatic symptoms of the patients, but no benefit was found for other clinical manifestations, such as neurological involvement. New strategies are currently being tested to address these limitations, in particular to obtain sufficient therapeutic levels in the brain. Read More

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http://dx.doi.org/10.1186/s13052-018-0564-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6238257PMC
November 2018
9 Reads

A new case report of severe mucopolysaccharidosis type VII: diagnosis, treatment with haematopoietic cell transplantation and prenatal diagnosis in a second pregnancy.

Ital J Pediatr 2018 Nov 16;44(Suppl 2):128. Epub 2018 Nov 16.

Clinica Pediatrica, Fondazione MBBM, Università Milano-Bicocca, Monza, Italy.

A new patient with severe mucopolysaccharidosis (MPS) type VII is reported. Non-immune hydrops fetalis (NIHF) was diagnosed during pregnancy. At birth, he showed generalized hydrops and dysmorphic features typical of MPS. Read More

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https://ijponline.biomedcentral.com/articles/10.1186/s13052-
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http://dx.doi.org/10.1186/s13052-018-0566-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6238262PMC
November 2018
10 Reads
1.240 Impact Factor

Enzyme replacement therapy: efficacy and limitations.

Ital J Pediatr 2018 Nov 16;44(Suppl 2):120. Epub 2018 Nov 16.

UOS Malattie Metaboliche Rare, Clinica Pediatrica dell'Università Milano Bicocca, Fondazione MBBM, ATS Monza e Brianza, Via Pergolesi 33, 20900, Monza, Italy.

Enzyme replacement therapy (ERT) is available for mucopolysaccharidosis (MPS) I, MPS II, MPS VI, and MPS IVA. The efficacy of ERT has been evaluated in clinical trials and in many post-marketing studies with a long-term follow-up for MPS I, MPS II, and MPS VI. While ERT is effective in reducing urinary glycosaminoglycans (GAGs) and liver and spleen volume, cartilaginous organs such as the trachea and bronchi, bones and eyes are poorly impacted by ERT probably due to limited penetration in the specific tissue. Read More

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https://ijponline.biomedcentral.com/articles/10.1186/s13052-
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http://dx.doi.org/10.1186/s13052-018-0562-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6238252PMC
November 2018
8 Reads

Neurobehavioral phenotypes of neuronopathic mucopolysaccharidoses.

Ital J Pediatr 2018 Nov 16;44(Suppl 2):121. Epub 2018 Nov 16.

UOS Malattie Metaboliche Rare, Clinica Pediatrica, Fondazione MBBM, ATS Monza, Monza, Italy.

Mucopolysaccharidoses (MPS) are a group of lysosomal multisystemic, chronic, and progressive diseases characterized by the storage of glycosaminoglycans (GAGs) that may affect the central nervous system. Neuronopathic MPS such as MPS IH, MPS II, MPS IIIA-D, and MPS VII are characterized by neurocognitive regression. In severe MPS I (MPS IH, or Hurler syndrome) initial developmental trajectory is usually unremarkable but cognitive development shows a plateau by 2 to 4 years of age and then progressively regresses with aging. Read More

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http://dx.doi.org/10.1186/s13052-018-0561-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6238256PMC
November 2018
8 Reads

Possible strategies to cross the blood-brain barrier.

Ital J Pediatr 2018 Nov 16;44(Suppl 2):131. Epub 2018 Nov 16.

Brains For Brain Foundation, Padova, Italy.

The mucopolysaccharidoses (MPS) are a heterogeneous group of in-born metabolic conditions caused by genetic defects that result in the absence or severe deficiency of one of the lysosomal hydrolases responsible for the degradation of glycosaminoglycans (GAGs). Such enzyme deficiency causes accumulation of GAGs that begins in infancy and progressively worsens, often affecting several organs including the central nervous system (CNS) inducing mental retardation, progressive neurodegeneration, and premature death. Over the last years, enormous progress has been made in the treatment of many MPS types, and available treatments are efficacious for many of them. Read More

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https://ijponline.biomedcentral.com/articles/10.1186/s13052-
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http://dx.doi.org/10.1186/s13052-018-0563-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6238258PMC
November 2018
11 Reads

Cerebral and occipito-atlanto-axial involvement in mucopolysaccharidosis patients: clinical, radiological, and neurosurgical features.

Ital J Pediatr 2018 Nov 16;44(Suppl 2):119. Epub 2018 Nov 16.

Department of Neurosurgery, University of Milan-Bicocca, San Gerardo Hospital, via G.B. Pergolesi 33, 20900, Monza, Italy.

Background: Neurosurgical features of mucopolysaccharidosis (MPS) patients mainly involve the presence of cranio-vertebral junction (CVJ) abnormalities and the development of communicating hydrocephalus. CVJ pathology is a critical aspect that severely influences the morbidity and mortality of MPS patients. Hydrocephalus is slowly progressing; it must be differentiated from cerebral atrophy, and rarely requires treatment. Read More

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http://dx.doi.org/10.1186/s13052-018-0558-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6238297PMC
November 2018

Gene therapy for mucopolysaccharidoses: in vivo and ex vivo approaches.

Ital J Pediatr 2018 Nov 16;44(Suppl 2):130. Epub 2018 Nov 16.

San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), IRCCS San Raffaele Scientific Institute, Via Olgettina, 60, 20123, Milan, Italy.

Mucopolysaccharidoses (MPS) are a group of lysosomal storage disorders caused by a deficiency in lysosomal enzymes catalyzing the stepwise degradation of glycosaminoglycans (GAGs). The current therapeutic strategies of enzyme replacement therapy and allogeneic hematopoietic stem cell transplantation have been reported to reduce patient morbidity and to improve their quality of life, but they are associated with persistence of residual disease burden, in particular at the neurocognitive and musculoskeletal levels. This indicates the need for more efficacious treatments capable of effective and rapid enzyme delivery to the affected organs, especially the brain and the skeleton. Read More

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https://ijponline.biomedcentral.com/articles/10.1186/s13052-
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http://dx.doi.org/10.1186/s13052-018-0565-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6238250PMC
November 2018
25 Reads