735 results match your criteria Isoniazid Hepatotoxicity


NAT2 polymorphisms associated with the development of hepatotoxicity after first-line tuberculosis treatment in Mexican patients: From genotype to molecular structure characterization.

Clin Chim Acta 2021 Apr 29;519:153-162. Epub 2021 Apr 29.

Centro de Investigación Biomédica del Noreste, Instituto Mexicano del Seguro Social, Calle 2 de abril - Jesús Dionisio González, Independencia, C.P. 64720 Monterrey, Nuevo León, Mexico. Electronic address:

Background And Aims: To assess the relevance of the slow acetylator phenotype based on NAT2 genotypes, among patients with pulmonary tuberculosis (PTB) that developed hepatotoxicity after first-line tuberculosis treatment in a Northeastern Mexican population.

Methods: Ninety one PTB patients were included, 7 of them developed hepatotoxicity. NAT2 SNPs (rs1801279, rs1041983, rs1801280, rs1799929, rs1799930, rs1208, and rs1799931) were genotyped by TaqMan allelic discrimination assay. Read More

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Study of clinical characteristics, risk factors and outcomes for tuberculosis post allogeneic stem cell transplant: never count it out.

Ther Adv Infect Dis 2021 Jan-Dec;8:20499361211008674. Epub 2021 Apr 12.

Department of Hematology and Bone Marrow Transplant Unit, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, Delhi 110085, India.

Background: Allogeneic stem cell transplant (AlloSCT) recipients remain at a higher risk of developing tuberculosis (TB), especially in endemic populations. We conducted a retrospective study to identify the incidence, clinical presentation, and risk factors for active TB among our alloSCT recipients.

Methods: Records of all patients transplanted between 1 January 2012 and 31 July 2020 were reviewed. Read More

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Gallic acid attenuates isoniazid and rifampicin-induced liver injury by improving hepatic redox homeostasis through influence on Nrf2 and NF-κB signalling cascades in Wistar Rats.

J Pharm Pharmacol 2021 Mar;73(4):473-486

Department of Biochemistry, JIPMER, Puducherry, India.

Objectives: Anti-TB drugs-isoniazid and rifampicin induced hepatotoxicity present a significant clinical problem. We aimed to evaluate the beneficial effect of gallic acid in anti-TB drug-induced liver injury in vivo and for the mechanism of action, we explored the influence of gallic acid on Nrf2 and NF-κB pathways.

Methods: We assessed serum liver function tests and histopathological analysis for the preventive effect of gallic acid on liver injury. Read More

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Determinants of Drug-Induced Hepatotoxicity Among Patients with Human Immunodeficiency Virus Taking a High Dose of Rifapentine Plus Isoniazid Drugs at the All Africa Leprosy Tuberculosis Rehabilitation and Training Center in Addis Ababa, Ethiopia.

HIV AIDS (Auckl) 2021 16;13:307-314. Epub 2021 Mar 16.

Addis Ababa Medical and Business College, Department of Research and Community Service, Addis Ababa, Ethiopia.

Purpose: The drugs for the treatment of latent Tuberculosis are potentially hepatotoxic and can lead to drug-induced hepatotoxicity. The current study aimed at identifying the determinants of anti-tuberculosis drug-induced hepatotoxicity among patients living with Human Immunodeficiency Virus taking Isoniazid and rifapentine at All Africa Leprosy Tuberculosis Rehabilitation and Training Center in Addis Ababa, Ethiopia.

Methods: An unmatched case-control study was conducted from March, 21, to April 21, 2020, at All Africa Leprosy Tuberculosis Rehabilitation and Training Center. Read More

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Tuberculosis despite latent infection screening and treatment in patients receiving TNF inhibitor therapy.

Clin Rheumatol 2021 Mar 20. Epub 2021 Mar 20.

Department of Chest Diseases, Ege University Faculty of Medicine, Izmir, Turkey.

Introduction: Although latent tuberculosis infection (LTBI) treatment is given before anti-tumor necrosis factor (TNF) treatment, tuberculosis (TB) still develops in these patients and the risk factors are not well known. Besides, there is little data on the safety of isoniazid (INH) treatment in this group of patients. This study aimed to determine the risk factors for the development of tuberculosis and the safety of LTBI in such patients. Read More

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Destructive Processes and Fibrotic Complications in the Liver of Mice with BSG-Induced Granulomatosis Treated with Anti-Tuberculous Drugs.

Bull Exp Biol Med 2021 Feb 13;170(4):466-470. Epub 2021 Mar 13.

Research Institute of Experimental and Clinical Medicine, Federal Research Center of Fundamental and Translational Medicine, Novosibirsk, Russia.

Three months after infection with Mycobacterium tuberculosis (MBT) from BCG vaccine, male BALB/с mice were treated with isonicotinic acid hydrazide, dextrazide (oxidized dextran), and liposome-encapsulated dextrazide intraperitoneally or in inhalations in a dose of 14 mg/kg (calculated for isoniazid) twice a week for 6 months. All these drugs exhibit different antimycobacterial efficiency. In the liver parenchyma, an up to 5-fold decrease in the number of destructed hepatocytes was observed depending on the efficiency of treatment. Read More

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February 2021

The promises and limitations of acetylcysteine as a potentiator of first-line and second-line tuberculosis drugs.

Antimicrob Agents Chemother 2021 Feb 22. Epub 2021 Feb 22.

Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA

acetylcysteine (NAC) is most commonly used for the treatment of acetaminophen overdose and acetaminophen-induced liver injury. In patients infected with , the causative agent of tuberculosis (TB), NAC is given to treat hepatotoxicity induced by TB drugs. We had previously shown that cysteine, a derivative of NAC, potentiated the activity of isoniazid, a first-line TB drug, by preventing the emergence of INH resistance and persistence in in vitro. Read More

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February 2021

Quercetin Modulates Nrf2 and NF-κB/TLR-4 Pathways to Protect against Isoniazid and Rifampicin Induced Hepatotoxicity .

Can J Physiol Pharmacol 2021 Feb 22. Epub 2021 Feb 22.

JIPMER, 29988, Department of Biochemistry, Puducherry, India;

Isoniazid and rifampicin are crucial for treating tuberculosis (TB); however, they can cause severe hepatotoxicity leading to liver failure. Therapeutic options are limited and ineffective. We hypothesized that prophylaxis with quercetin attenuates isoniazid and rifampicin induced liver injury. Read More

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February 2021

[Isoniazid-inducedtoxic hepatitis].

Ugeskr Laeger 2021 Feb;183(6)

Hepatotoxicity is a well-known side effect to isoniazid treatment with the risk of progression to liver failure. This case report describes a 39-year-old male, who received standard isoniazid treatment for latent TB infection (LTBI) and developed severe isoniazid-induced acute hepatitis. Liver transplantation was considered, but the patient slowly recovered with full hepatic regeneration. Read More

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February 2021

Toxicity studies of highly bioavailable isoniazid loaded solid lipid nanoparticles as per Organisation for Economic Co-operation and Development (OECD) guidelines.

Eur J Pharm Biopharm 2021 Mar 24;160:82-91. Epub 2021 Jan 24.

University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India. Electronic address:

Solid lipid nanoparticles (SLNs) are presently being promoted to improve bioavailability of encapsulated drugs. These are well tolerated in living systems, as they are made from biocompatible material. Despite finding extensive applicability, these systems have not been sufficiently investigated for the toxicity so far. Read More

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Ameliorative potential of Adhatoda vasica against anti-tubercular drugs induced hepatic impairments in female Wistar rats in relation to oxidative stress and xeno-metabolism.

J Ethnopharmacol 2021 Apr 31;270:113771. Epub 2020 Dec 31.

Department of Zoology, Panjab University, Chandigarh, 160014, India. Electronic address:

Ethnopharmacological Relevance: Adhatoda vasica Nees is widely used herb of indigenous system to treat various ailments especially upper respiratory tract infections. Not only, anti-tubercular efficacy of crude extract and phytoconstituents of A. vasica has been documented but its hepatoprotective role against various drugs mediated hepatic alterations in different animal models has also been observed. Read More

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Evaluation of 6-Month Versus Continuous Isoniazid Preventive Therapy for Mycobacterium tuberculosis in Adults Living With HIV/AIDS in Malawi.

J Acquir Immune Defic Syndr 2020 12;85(5):643-650

Emerging Diseases Epidemiology Unit, Institut Pasteur, Paris, France.

Background: To assist the Malawi Ministry of Health to evaluate 2 competing strategies for scale-up of isoniazid preventive therapy (IPT) among HIV-positive adults receiving antiretroviral therapy.

Setting: Malawi.

Methods: We used a multidistrict, compartmental model of the Malawi tuberculosis (TB)/HIV epidemic to compare the anticipated health impacts of 6-month versus continuous IPT programs over a 12-year horizon while respecting a US$10. Read More

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December 2020

Magnitude, outcome, and associated factors of anti-tuberculosis drug-induced hepatitis among tuberculosis patients in a tertiary hospital in North Ethiopia: A cross-sectional study.

PLoS One 2020 10;15(11):e0241346. Epub 2020 Nov 10.

School of Public Health, College of Health Sciences, Mekelle University, Mekelle, Ethiopia.

Background: Short-course chemotherapy comprising isoniazid, rifampicin, ethambutol, and pyrazinamide has proved to be highly effective in the treatment of tuberculosis (TB). However, the most common adverse effect of this regimen leading to interruption of therapy is hepatotoxicity. There is a paucity of evidence in Tigray region on anti-tuberculosis drug-induced hepatitis. Read More

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December 2020

Fatal Isoniazid Hepatotoxicity in the Deployed Environment.

Mil Med 2021 05;186(5-6):619-622

Craig Joint Theater Hospital, 455th Expeditionary Medical Group, Bagram, AE 09354, Afghanistan.

Deployed clinicians have limited resources at their disposal to augment medical decision-making and management. All deploying personnel undergo predeployment medical assessment to evaluate their fitness for deployment. The purpose of predeployment screening is to allow for anticipation of medical needs that may arise which could challenge the available medical resources in an expeditionary environment. Read More

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Transbuccal Delivery of Isoniazid: Ex Vivo Permeability and Drug-Surfactant Interaction Studies.

AAPS PharmSciTech 2020 Oct 20;21(8):289. Epub 2020 Oct 20.

Programa de Pós-Graduação em Farmácia, Universidade Federal de Santa Catarina, Campus Universitário, Trindade, Florianópolis, SC, 88040-900, Brazil.

The oral administration of isoniazid (INH) may lead to discontinuation of tuberculosis treatment due to drug-related hepatotoxicity events, and thus, the transbuccal delivery of this drug was investigated, for the first time, as an alternative administration route. Ex vivo permeability assays were performed in Franz-type diffusion chambers, applying INH alone and in combination with sodium dodecyl sulfate (SDS) and sodium taurocholate (ST). After confirming the formation of micelle structures by dynamic light scattering analysis, UV-visible spectroscopy and zeta potential analyses were used to investigate drug-micelle interactions. Read More

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October 2020

Anti-Tuberculosis Treatment: Induced Hepatotoxicity - A Case Report.

EJIFCC 2020 Sep 29;31(3):242-247. Epub 2020 Sep 29.

Department of Pharmacy Practice, Malla Reddy Pharmacy College, Dhulapally, Secunderabad, Telangana, India.

Tuberculosis is a potentially communicable disease that can infect any organ in the body such as bones, kidney, intestine but primarily involves lung parenchyma (Pulmonary tuberculosis). The prevalence of TB is 256 per 100,000 population in India. Hepatotoxicity, gastrointestinal and neurological disorders were some the Adverse Drug Reactions (ADR's) reported that significantly increases the mortality rate which leads to decreased efficacy of the treatment. Read More

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September 2020

Incidence and associated risk factors of antituberculosis drug-induced hepatotoxicity among hospitalised patients in Wuhan, China.

Eur J Hosp Pharm 2020 Sep 28. Epub 2020 Sep 28.

Department of Pharmacy, Renmin Hospital of Wuhan University, Wuhan, Hubei, China

Objective: To analyse the incidence and risk factors of hepatotoxicity induced by antituberculosis (anti-TB) drugs in Renmin Hospital of Wuhan University, and to provide evidence for clinical prevention and treatment of anti-TB drug damage.

Methods: A retrospective analysis of patients who received first-line anti-TB drugs from January 2016 to December 2018 in Renmin Hospital of Wuhan University was conducted. Univariate analysis and binary logistic regression analysis with the forward stepwise method were used to assess the risk factors associated with hepatotoxicity induced by anti-TB drugs. Read More

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September 2020

Empiric vs screening-based use of isoniazid for tuberculosis prophylaxis: Safety and effectiveness in lung transplant recipients in Saudi Arabia.

Transpl Infect Dis 2021 Apr 8;23(2):e13473. Epub 2020 Oct 8.

Section of Infectious Diseases, Department of Medicine, King Faisal Specialist Hospital & Research Center, Riyadh, Saudi Arabia.

Background: Tuberculosis (TB) is a major complication following transplantation. The likelihood of TB may be increased in transplant patients living in TB-endemic areas such as Saudi Arabia. In areas where TB is less common, guidelines recommend isoniazid (INH) for TB prophylaxis depending on patient and donor screening results. Read More

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Potential drug-drug interactions associated with adverse clinical outcomes and abnormal laboratory findings in patients with malaria.

Malar J 2020 Aug 31;19(1):316. Epub 2020 Aug 31.

Department of Pharmacy, University of Peshawar, Khyber Pakhtunkhwa, Pakistan.

Background: Hospitalized patients with malaria often present with comorbidities or associated complications for which a variety of drugs are prescribed. Multiple drug therapy often leads to drug-drug interactions (DDIs). Therefore, the current study investigated the prevalence, levels, risk factors, clinical relevance, and monitoring parameters/management guidelines of potential DDIs (pDDIs) among inpatients with malaria. Read More

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Redox Imbalance and Oxidative DNA Damage During Isoniazid Treatment of HIV-Associated Tuberculosis: A Clinical and Translational Pharmacokinetic Study.

Front Pharmacol 2020 29;11:1103. Epub 2020 Jul 29.

Public Health Research Institute, New Jersey Medical School, Newark, NJ, United States.

Background: The potential for hepatotoxicity during isoniazid-based tuberculosis (TB) treatment presents a major challenge for TB control programs worldwide. We sought to determine whether pharmacokinetic exposures of isoniazid and its metabolites were related to cellular oxidation/reduction status and downstream markers of oxidative DNA damage.

Methods: We performed intensive pharmacokinetic sampling among isoniazid-treated patients to determine the relative plasma exposures of isoniazid, acetylisoniazid, hydrazine, and acetylhydrazine. Read More

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A case series of three patients presenting with isoniazid induced toxicity and N-acetyl transferase 2 gene mutation: A management conundrum for programmatic therapy of tuberculosis in India.

Indian J Tuberc 2020 Jul 20;67(3):407-410. Epub 2020 Jan 20.

Department of Medicine, LTM Medical College & LTM General Hospital, Mumbai, India.

Isoniazid is an essential drug in the management of tuberculosis but there is a high degree of variation in the Indian population's capacity to acetylate or inactivate isoniazid to the inactive metabolite acetyl isoniazid, and they can be distinctly characterized phenotypically as being either slow or rapid inactivators (the concentration of the enzyme being higher in rapid inactivators). Several mutations in the N-acetyl transference 2 (NAT2) gene account for majority of the slow acetylator genotypes in the human population (NAT2*5A, NAT2*5B, and NAT2*6A). Such individuals are at a greater risk of drug-induced adverse reactions due to reduced drug elimination, compared to those possessing the wild type allele. Read More

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Latent Tuberculosis Therapy Outcomes in Dialysis Patients: A Retrospective Cohort.

Am J Kidney Dis 2021 05 17;77(5):696-703. Epub 2020 Aug 17.

British Columbia Centre for Disease Control, Vancouver, Canada; Provincial Health Services Authority, Vancouver, Canada; University of British Columbia, Vancouver, Canada. Electronic address:

Rationale & Objectives: Maintenance dialysis patients are at an increased risk for active tuberculosis (TB). In 2012, British Columbia, Canada, began systematically screening maintenance dialysis patients for latent TB infection (LTBI) and treating people with evidence of LTBI when appropriate. We examined LTBI treatment outcomes and compared treatment outcomes before and after rollout of the systematic screening program. Read More

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Naphthoquinone-based hydrazone hybrids: synthesis and potent activity against cancer cell lines.

Med Chem 2020 Aug 17. Epub 2020 Aug 17.

Graduate College of Health and Biological Sciences, Federal University of San Francisco Valley, Petrolina, PE. Brazil.

Background: Natural naphthoquinones have shown diversified biological activities including antibacterial, antifungal, antimalarial, and cytotoxic activities. However, they are also compounds with acute cytotoxicity, immunotoxicity, carcinogenesis, and cardio- and hepatotoxicity, then the modification at their redox center is an interesting strategy to overcome such harmful activity.

Objective: In this study, four novel semisynthetic hydrazones, derived from the isomers α- and β-lapachones (α and β, respectively) and coupled with the drugs hydralazine (HDZ) and isoniazid (ACIL), were prepared, evaluated by electrochemical methods and assayed for anticancer activity. Read More

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Evidence of drug-induced hepatotoxicity in the Maghrebian population.

Drug Chem Toxicol 2020 Jul 26:1-5. Epub 2020 Jul 26.

Faculty of Medicine and Pharmacy, Laboratory of Chemistry-Biochemistry, Environment, Nutrition, and Health, Hassan II University, Casablanca, Morocco.

Drug-induced hepatotoxicity is one of the most challenging hepatic diseases faced nowadays due to a large number of drugs currently used in clinical practice, the enormous dietary supplements which are potentially hepatotoxic, as well as the ability to appear with different clinical symptoms and the absence of specific markers. The current research survey was conducted to investigate drug-induced hepatotoxicity and demographic characteristics of patients with liver damage in the general Maghrebian population between 1992 and 2018. To achieve this goal a questionnaire was adopted to report details on the undesirable effects of drugs and demographic characteristics of affected patients. Read More

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The high incidence of severe adverse events due to pyrazinamide in elderly patients with tuberculosis.

PLoS One 2020 21;15(7):e0236109. Epub 2020 Jul 21.

Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam-Si, Gyeonggi-Do, South Korea.

Background: Pyrazinamide (PZA) is a common drug that causes serious adverse events (SAEs). The aim of this study was to determine the incidence of and risk factors for SAEs due to PZA during first-line anti-tuberculosis treatment.

Methods: The medical records of patients with tuberculosis (TB) treated with PZA-containing regimens including first-line drugs-ethambutol, rifampicin, and isoniazid-from January 2003 to June 2016 were reviewed. Read More

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September 2020

Pyridoxal isonicotinoyl hydrazone inhibition of FXR is involved in the pathogenesis of isoniazid-induced liver injury.

Toxicol Appl Pharmacol 2020 09 14;402:115134. Epub 2020 Jul 14.

Department of Pharmacy, the First Hospital of Lanzhou University, Lanzhou 730000, China,. Electronic address:

Isoniazid (INH)-induced liver injury may be associated with inhibition of the liver farnesoid X receptor (FXR). However, the relationship between FXR and INH-induced liver injury remained unclear. The present study was performed to clarify the role of inhibition of FXR in the pathogenesis of INH-induced liver injury and to further identify potential inhibitors of FXR from INH and its metabolites. Read More

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September 2020

Toxicoproteomic Profiling of Transgenic Mice Treated with Rifampicin and Isoniazid.

Cells 2020 07 9;9(7). Epub 2020 Jul 9.

Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.

Tuberculosis is a global health threat that affects millions of people every year, and treatment-limiting toxicity remains a considerable source of treatment failure. Recent reports have characterized the nature of -mediated hepatotoxicity and the systemic toxicity of antitubercular drugs. The antitubercular drug isoniazid plays a role in such pathologic states as acute intermittent porphyria, anemia, hepatotoxicity, hypercoagulable states (deep vein thrombosis, pulmonary embolism, or ischemic stroke), pellagra (vitamin B deficiency), peripheral neuropathy, and vitamin B deficiency. Read More

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Meta-analysis on Effectiveness and Safety of Moxifloxacin in Treatment of Multidrug Resistant Tuberculosis in Adults.

Medicine (Baltimore) 2020 Jun;99(25):e20648

Department of Dermatology & STD, The Third Central Hospital of Tianjin.

Background: Moxifloxacin, a fourth generation fluoroquinolone, which has good antibacterial activity against both Gram-positive cocci and Gram-negative bacteria. To date, there are no meta-analysis to evaluate the efficacy and safety of moxifloxacin for multi-drug resistant tuberculosis (MDR-TB) treatment. This meta-analysis to explore the efficacy and safety of the moxifloxacin in treatment of MDR-TB in adults. Read More

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Efficacy and safety of weekly rifapentine and isoniazid for tuberculosis prevention in Chinese silicosis patients: a randomized controlled trial.

Clin Microbiol Infect 2021 Apr 15;27(4):576-582. Epub 2020 Jun 15.

Department of Infectious Diseases, Huashan Hospital, Fudan University, Shanghai 200040, China; National Clinical Research Centre for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai 200040, China; Key Laboratory of Medical Molecular Virology (MOE/MOH) and Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai 200032, China; State Key Laboratory of Genetic Engineering, School of Life Science, Fudan University, Shanghai 200438, China. Electronic address:

Objective: The aim was to evaluate the efficacy, safety and completion rate of 3-month, once-weekly rifapentine and isoniazid for tuberculosis (TB) prevention among Chinese silicosis patients.

Methods: Male silicosis patients without human immunodeficiency virus infection, aged 18 years to 65 years, with or without latent TB infection, were randomized 1:1 to receive rifapentine/isoniazid under direct observation (3RPT/INH group) or were untreated (observation group). Active TB incidence was compared between the two groups with 37 months of follow-up. Read More

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