700 results match your criteria Isoniazid Hepatotoxicity


An Evaluation of the In Vitro Roles and Mechanisms of Silibinin in Reducing Pyrazinamide- and Isoniazid-Induced Hepatocellular Damage.

Int J Mol Sci 2020 May 25;21(10). Epub 2020 May 25.

Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore 117543, Singapore.

Tuberculosis remains a significant infectious lung disease that affects millions of patients worldwide. Despite numerous existing drug regimens for tuberculosis, drug-induced liver injury is a major challenge that limits the effectiveness of these therapeutics. Two drugs that form the backbone of the commonly administered quadruple antitubercular regimen, that is, pyrazinamide (PZA) and isoniazid (INH), are associated with such hepatotoxicity. Read More

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http://dx.doi.org/10.3390/ijms21103714DOI Listing

Abnormal Levels of Liver Enzymes and Hepatotoxicity in HIV-Positive, TB, and HIV/TB-Coinfected Patients on Treatment in Fako Division, Southwest Region of Cameroon.

Biomed Res Int 2020 12;2020:9631731. Epub 2020 May 12.

Infectious Disease Laboratory, Faculty of Health Sciences, University of Buea, P.O. Box 63, Buea, Cameroon.

Hepatotoxicity is historically the 3 most common reason for drug withdrawal and toxicity-related discontinuation of treatment. This study was aimed at determining the incidence and the onset of hepatotoxicity and at evaluating the relationship of some risk factors for hepatotoxicity among Human Immunodeficiency Virus- (HIV-) positive, tuberculosis (TB), and HIV/TB patients on treatment. This was a prospective follow-up study involving 125 participants from the HIV/AIDS and TB treatment centres in three hospitals in Fako Division of Cameroon. Read More

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http://dx.doi.org/10.1155/2020/9631731DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243024PMC

Bile acids, lipid and purine metabolism involved in hepatotoxicity of first-line anti-tuberculosis drugs.

Expert Opin Drug Metab Toxicol 2020 Jun 21;16(6):527-537. Epub 2020 May 21.

Department of Clinical Pharmacology, The First Affiliated Hospital of Soochow University , Suzhou, China.

Objectives: Rifampin (RIF), isoniazid (INH) and pyrazinamide (PZA) are essential components of the short-term first-line anti-tuberculosis (anti-TB) chemotherapy regimen and can cause hepatotoxicity. However, the mechanism of anti-TB drug-induced hepatotoxicity (ATDH) is currently unclear. We investigate the relevant contributions to liver injury and the pathway of the above-mentioned drugs administered alone or in combination. Read More

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http://dx.doi.org/10.1080/17425255.2020.1758060DOI Listing

First-line tuberculosis treatment with double-dose rifampicin is well tolerated.

Int J Tuberc Lung Dis 2020 May;24(5):499-505

Institute of Tropical Medicine, Antwerp, The Union, Paris, France.

To compare the occurrence of unfavourable treatment and safety outcomes of double-dose rifampicin (RMP; 20 mg/kg/d, intervention) with standard dose (10 mg/kg/d, control) in a first-line tuberculosis (TB) treatment regimen for smear-positive TB patients in Bangladesh. This was a randomised clinical trial. The primary efficacy and safety endpoints were the occurrence of an unfavourable treatment outcome (death, failure, relapse or loss to follow-up) and the occurrence of any serious drug-related adverse event (SAE). Read More

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http://dx.doi.org/10.5588/ijtld.19.0063DOI Listing

Association between NR1I2 polymorphisms and susceptibility to anti-tuberculosis drug-induced hepatotoxicity in an Eastern Chinese Han population: A case-control study.

Infect Genet Evol 2020 May 7;83:104349. Epub 2020 May 7.

Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing 211166, China. Electronic address:

Objective: Anti-tuberculosis drug-induced hepatotoxicity (ATDH) is a serious adverse drug reaction, and its pathogenic mechanism is still largely unknown. Pregnane X receptor (PXR, encoded by the NR1I2 gene) is a ligand-dependent transcription factor, and rifampicin is a human PXR-specific activator. Rifampicin and isoniazid co-therapy targets porphyrin biosynthesis via PXR and results in hepatic protoporphyrin IX accumulation and subsequent liver injury. Read More

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http://dx.doi.org/10.1016/j.meegid.2020.104349DOI Listing

Cocrystallization with syringic acid presents a new opportunity for effectively reducing the hepatotoxicity of isoniazid.

Drug Dev Ind Pharm 2020 Jun 14;46(6):988-995. Epub 2020 May 14.

School of Medicine and Pharmacy and College of Marine Life Science, Ocean University of China, Qingdao, PR China.

With the aim of surmounting the severe hepatotoxicity induced by antituberculosis drug isoniazid (INH), a novel cocrystal of INH with hepatoprotective nutraceutical syringic acid (SYA), namely INH-SYA, was designed and prepared through cocrystallization strategy, which is an intriguing attempt to reduce the toxic side effects of INH. The study not only provides new thinking for inhibiting toxic side effects of drugs through cocrystallization strategy, but also opens a new pathway for the application of nutraceuticals in the pharmacy. INH and SYA were successfully crystallized into the same crystal lattice through combining volatilization with solvent assisted methods. Read More

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http://dx.doi.org/10.1080/03639045.2020.1764024DOI Listing
June 2020
2.006 Impact Factor

Efficacy of Inhalations of Antituberculous Compositions with Different Length of Experimental Therapy Course in Mice.

Bull Exp Biol Med 2020 Apr 23;168(6):743-747. Epub 2020 Apr 23.

Research Institute of Experimental and Clinical Medicine, Federal Research Center of Fundamental and Translational Medicine, Novosibirsk, Russia.

The study compared antituberculous efficacy of individual or combined administration of "free" isoniazid and liposomal form of dextrazide (a composition consisted of isoniazid and oxidized dextran) inhaled in standard (15 mg/kg) or low (3 mg/kg) dose. The therapy started 1 month after contamination of outbred ICR male mice with Mycobacterium tuberculosis strain H37Rv. Combined inhalation of liposomal form of dextrazide and isoniazid in the low dose was most effective against mycobacterium tuberculosis due to diminished prodestructive pulmonary effect and a low hepatotoxicity. Read More

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http://dx.doi.org/10.1007/s10517-020-04793-xDOI Listing

Adherence to nine-month isoniazid for latent tuberculosis infection in healthcare workers: a prospective study in a tertiary hospital.

Sci Rep 2020 Apr 15;10(1):6462. Epub 2020 Apr 15.

Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea.

Poor adherence to medication can lead to treatment failure in healthcare workers (HWCs) with latent tuberculosis infection (LTBI) who are at high risk of developing active tuberculosis. However, the factors associated with non-completion of nine-month LTBI treatment with isoniazid (9 H) have not been well studied. We investigated the completion rate and factors affecting adherence to LTBI treatment with 9 H among HCWs. Read More

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http://dx.doi.org/10.1038/s41598-020-63156-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7160120PMC
April 2020
5.078 Impact Factor

Isoniazid Induced Pure Red Blood Cell Aplasia.

Cureus 2020 Feb 27;12(2):e7112. Epub 2020 Feb 27.

Hematology/Oncology, Southern Illinois University School of Medicine, Springfield, USA.

Pure red blood cell aplasia (PRCA) is one of the uncommon causes of anemia. Drug-induced PRCA is even more infrequent. Only a few drugs are implicated in PRCA. Read More

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http://dx.doi.org/10.7759/cureus.7112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7101238PMC
February 2020

The safety of isoniazid tuberculosis preventive treatment in pregnant and postpartum women: systematic review and meta-analysis.

Eur Respir J 2020 Mar 26;55(3). Epub 2020 Mar 26.

Global TB Program (GTB), World Health Organization, Geneva, Switzerland.

Background: The World Health Organization (WHO) recommends tuberculosis (TB) preventive treatment for high-risk groups. Isoniazid preventive therapy (IPT) has been used globally for this purpose for many years, including in pregnancy. This review assessed current knowledge about the safety of IPT in pregnancy. Read More

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http://dx.doi.org/10.1183/13993003.01967-2019DOI Listing

Phytochemical analysis and Evaluation of hepatoprotective effect of Maytenus royleanus leaves extract against anti-tuberculosis drug induced liver injury in mice.

Lipids Health Dis 2020 Mar 16;19(1):46. Epub 2020 Mar 16.

Department of Biochemistry, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, 45320, Pakistan.

Background: Myrin®-p Forte is an anti-tuberclosis agent that can cause hepatic injuries in clinical settings. Maytenus royleanus (Celastraceae) is a medicinal plant, possesses antioxidant and anticancer activities. The hepatoprotective effect of the methanol extract of Maytenus royleanus leaves (MEM) against Myrin®-p Forte induced hepatotoxicity in mice was investigated. Read More

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http://dx.doi.org/10.1186/s12944-020-01231-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7077109PMC
March 2020
2.219 Impact Factor

GC/MS assisted phytochemical analysis of Ajuga parviflora leaves extract along with anti-hepatotoxic effect against anti-tubercular drug induced liver toxicity in rat.

Pak J Pharm Sci 2020 Jan;33(1(Supplementary)):325-331

Department of Pharmacology, Faculty of Pharmacy, Federal Urdu University of Arts, Science and Technology, Karachi, Pakistan.

Owing to its traditional applications, the current study focuses on Ajuga parviflora (A. parviflora) leaves extract for phytochemical and pharmacological analysis. The principle constituents were identified through gas chromatography (GC), and gas chromatography/mass spectroscopy (GC/MS), these includes phthalic acid, squalene, α-tocopherol, vitamin E, phytol, 2-methylenecholestan-3-ol, stigmasterol, cholest-22-ene-21-ol and 3,5-dehydro-6-methoxy. Read More

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January 2020

Frequency, Risk Factors, and Outcome of Active Tuberculosis following Allogeneic Hematopoietic Stem Cell Transplantation.

Biol Blood Marrow Transplant 2020 Jun 24;26(6):1203-1209. Epub 2020 Feb 24.

Peking University People's Hospital, Peking University Institute of Hematology, Beijing, China; Collaborative Innovation Center of Hematology, Peking University, Beijing, China; Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, China; National Clinical Research Center for Hematologic Disease, Beijing, China. Electronic address:

We aimed to investigate the frequency, risk factors, and outcome of active tuberculosis (TB) after allogeneic hematopoietic stem cell transplantation (allo-HSCT). This retrospective, nested, case-control study reviewed data from 6236 patients who received allo-HSCT from January 2008 to December 2018 at a single center; thirty-three patients (0.5%) with active TB and 99 controls without active TB after allo-HSCT were identified. Read More

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http://dx.doi.org/10.1016/j.bbmt.2020.02.018DOI Listing

Guidelines for the Treatment of Latent Tuberculosis Infection: Recommendations from the National Tuberculosis Controllers Association and CDC, 2020.

MMWR Recomm Rep 2020 Feb 14;69(1):1-11. Epub 2020 Feb 14.

Comprehensive guidelines for treatment of latent tuberculosis infection (LTBI) among persons living in the United States were last published in 2000 (American Thoracic Society. CDC targeted tuberculin testing and treatment of latent tuberculosis infection. Am J Respir Crit Care Med 2000;161:S221-47). Read More

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http://dx.doi.org/10.15585/mmwr.rr6901a1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7041302PMC
February 2020

Model-Based Assessment of Variability in Isoniazid Pharmacokinetics and Metabolism in Patients Co-Infected With Tuberculosis and HIV: Implications for a Novel Dosing Strategy.

Clin Pharmacol Ther 2020 Feb 4. Epub 2020 Feb 4.

Unit for Pharmacokinetics and Drug Metabolism, Department of Pharmacology, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.

Tuberculosis is the most common cause of death in HIV-infected patients. Isoniazid is used as a first-line drug to treat tuberculosis infection. However, variability in isoniazid pharmacokinetics can result in hepatotoxicity or treatment failure. Read More

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http://dx.doi.org/10.1002/cpt.1806DOI Listing
February 2020

Treatment with isoniazid or rifampin for latent tuberculosis infection: population-based study of hepatotoxicity, completion and costs.

Eur Respir J 2020 Mar 20;55(3). Epub 2020 Mar 20.

Dept of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, QC, Canada

Clinical trials suggest less hepatotoxicity and better adherence with 4 months rifampin (4R) 9 months isoniazid (9H) for treating latent tuberculosis infection (LTBI). Our objectives were to compare frequencies of severe hepatic adverse events and treatment completion, and direct health system costs of LTBI regimens 4R and 9H, in the general population of the province of Quebec, Canada, using provincial health administrative data.Our retrospective cohort included all patients starting rifampin or isoniazid regimens between 2003 and 2007. Read More

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http://dx.doi.org/10.1183/13993003.02048-2019DOI Listing

A new cocrystal of isoniazid-quercetin with hepatoprotective effect: The design, structure, and in vitro/in vivo performance evaluation.

Eur J Pharm Sci 2020 Mar 13;144:105216. Epub 2020 Jan 13.

School of Medicine and Pharmacy and College of Marine Life Science, Ocean University of China, Qingdao, Shandong 266003, PR China. Electronic address:

With the purpose of overcoming the serious hepatotoxicity of antituberculosis drug isoniazid (INH), a cocrystallization strategy based on complementary advantages was implemented by choosing the hepatoprotective nutraceutical quercetin (QCT) as the cocrystal former. The strategy plays the solubility advantage of INH to improve the bioavailability of the insoluble QCT, thereby significantly enhancing the QCT's hepatoprotective effects. The optimized protective effects of QCT, in turn, feed back to INH to reduce its hepatotoxicity. Read More

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http://dx.doi.org/10.1016/j.ejps.2020.105216DOI Listing
March 2020
3.350 Impact Factor

Design, Synthesis and In Vitro Characterization of Novel Antimicrobial Agents Based on 6-Chloro-9-carbazol Derivatives and 1,3,4-Oxadiazole Scaffolds.

Molecules 2020 Jan 9;25(2). Epub 2020 Jan 9.

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, "Carol Davila" University of Medicine and Pharmacy, 6 TraianVuia, 020956 Bucharest, Romania.

In this paper, we aimed to exploit and combine in the same molecule the carbazole and the 1,3,4-oxadiazole pharmacophores, to obtain novel carprofen derivatives, by using two synthesis pathways. For the first route, the following steps have been followed: (i) ()-2-(6-chloro-9-carbazol-2-yl)propanonic acid (carprofen) treatment with methanol, yielding methyl ()-2-(6-chloro-9-carbazol-2-yl)propanoate; (ii) the resulted methylic ester was converted to ()-2-(6-chloro-9-carbazol-2-yl)propane hydrazide (carprofen hydrazide) by treatment with hydrazine hydrate; (iii) reaction of the hydrazide derivative with acyl chlorides led to -[(2)-2-(6-chloro-9-carbazol-2-yl)propanoil]-'--substituted-benzoylhydrazine formation, which; (iv) in reaction with phosphorus oxychloride gave the ()-1-(6-chloro-9-carbazol-2-yl)-1-(1,3,4-oxadiazol-2-yl)ethane derivatives. In the second synthesis pathway, new 1,3,4-oxadiazole ring compounds were obtained starting from carprofen which was reacted with isoniazid, in the presence of phosphorus oxychloride to form ()-1-(6-chloro-9-carbazol-2-yl)-1-[5-(4-pyridyl)-1,3,4-oxadiazol-2-yl]ethane. Read More

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http://dx.doi.org/10.3390/molecules25020266DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7024163PMC
January 2020

Risk of hepatitis with various reintroduction regimens of anti-tubercular therapy: a systematic review and network meta-analysis.

Expert Rev Anti Infect Ther 2020 Feb 15;18(2):171-179. Epub 2020 Jan 15.

Department of Gastroenterology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

: To compare risk of hepatotoxicity between various regimens for reintroduction of antitubercular therapy (ATT) in patients with previous episode of ATT hepatitis.: We searched various databases (PubMed, Embase, CENTRAL, Scopus, WoS and LILACS) for studies comparing ATT reintroduction regimens using terms 'drug-induced liver injury' and 'antitubercular drugs' AND 'reintroduction'. The reintroduction regimens i. Read More

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http://dx.doi.org/10.1080/14787210.2020.1714436DOI Listing
February 2020
3.461 Impact Factor

Screening and Treatment of Latent Tuberculosis Infection among Healthcare Workers at a Referral Hospital in Korea.

Infect Chemother 2019 Dec;51(4):355-364

Respiratory and Allergy Medicine, Department of Internal Medicine, Soonchunhyang University Seoul Hospital, Soonchunhyang University College of Medicine, Seoul, Korea.

Background: Healthcare workers (HCWs) have a high risk of tuberculosis (TB) infection. Since August 2017, Korea has mandated the testing of latent TB infection (LTBI) and recommended treatment from HCWs at medical institutions. However, the acceptance/completion rate and adverse events of LTBI treatment have not been analyzed. Read More

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http://dx.doi.org/10.3947/ic.2019.51.4.355DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6940377PMC
December 2019

Flow-Based Three-Dimensional Co-Culture Model for Long-Term Hepatotoxicity Prediction.

Micromachines (Basel) 2019 Dec 27;11(1). Epub 2019 Dec 27.

Department of HBP Surgery & Liver Transplantation, Department of Surgery, Korea University College of Medicine, Seoul 02841, Korea.

We developed concave microwell arrays to establish a size-controllable 3-D co-culture liver model for in vitro drug toxicity testing, to predict hepatotoxicity. The interaction of hepatocytes with hepatic stellate cells (HSCs) was investigated by co-culturing primary 3-D hepatocyte spheroids and HSCs (heterosphere), using 3-D liver-on-a-chip. The effect of HSCs was investigated during spheroid formation; they were involved in controlling the organization of spheroidal aggregates and the formation of tight cell-cell contacts. Read More

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http://dx.doi.org/10.3390/mi11010036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7019533PMC
December 2019

Protective effect of pyrrolidine dithiocarbamate on isoniazid/rifampicin‑induced liver injury in rats.

Mol Med Rep 2020 Jan 12;21(1):463-469. Epub 2019 Nov 12.

Department of Gastroenterology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, P.R. China.

Isoniazid (INH) and rifampicin (RIF) continue to be first line anti‑tuberculosis (TB) drugs. However, the use of these drugs is associated with hepatotoxicity. Nuclear factor‑κB (NF‑κB) plays a crucial role in regulating immunity and inflammation. Read More

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http://dx.doi.org/10.3892/mmr.2019.10817DOI Listing
January 2020
1.484 Impact Factor

Possible Pathways of Hepatotoxicity Caused by Chemical Agents.

Curr Drug Metab 2019 ;20(11):867-879

Department of Pharmaceutical Sciences, University of Kashmir, Pharmacognosy Division, Hazratbal, Srinagar 190006, Kashmir, India.

Background: Liver injury induced by drugs has become a primary reason for acute liver disease and therefore posed a potential regulatory and clinical challenge over the past few decades and has gained much attention. It also remains the most common cause of failure of drugs during clinical trials. In 50% of all acute liver failure cases, drug-induced hepatoxicity is the primary factor and 5% of all hospital admissions. Read More

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http://dx.doi.org/10.2174/1389200220666191105121653DOI Listing

Relationship of anti-tuberculosis drug-induced liver injury and genetic polymorphisms in CYP2E1 and GST.

Braz J Infect Dis 2019 Nov - Dec;23(6):381-387. Epub 2019 Nov 4.

Universidade Federal do Rio de Janeiro, Faculdade de Farmácia, Departamento de Fármacos e Medicamentos, Rio de Janeiro, RJ, Brazil; Fundação Oswaldo Cruz, Instituto Nacional de Doenças Infecciosas Evandro Chagas, Laboratório de Pesquisa Clínica em DST/AIDS, Rio de Janeiro, RJ, Brazil.

Setting: Treatment of tuberculosis (TB) can result in Drug-Induced Liver Injury (DILI) since hepatotoxic metabolites are formed during the biotransformation of isoniazid (INH). DILI can be related to the genetic profile of the patient. Single nucleotide polymorphisms in the CYP2E1 gene and GSTM1 and GSTT1 deletion polymorphisms have been associated with adverse events caused by INH. Read More

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http://dx.doi.org/10.1016/j.bjid.2019.09.003DOI Listing

Electroanalysis of isoniazid and rifampicin: Role of nanomaterial electrode modifiers.

Biosens Bioelectron 2019 Dec 4;146:111731. Epub 2019 Oct 4.

Department of Mycobacteriology and Pulmonary Research, Pasteur Institute of Iran, Tehran, 1316943551, Iran; Microbiology Research Center (MRC), Pasteur Institute of Iran, Tehran, 1316943551, Iran. Electronic address:

Thanks to operational simplicity, speediness, possibility of miniaturization and real-time nature, electrochemical sensing is a supreme alternative for non-electrochemical methodologies in drug quantification. This review, highlights different nanotech-based sensory designs for electroanalysis of isoniazid and rifampicin, the most important medicines for patients with tuberculosis. We first, concisely mention analyses with bare electrodes, associated impediments and inspected possible strategies and then critically review the last two decades works with focus on different nano-scaled electrode modifiers. Read More

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http://dx.doi.org/10.1016/j.bios.2019.111731DOI Listing
December 2019
2 Reads

Adverse event and treatment completion rates of a 12-dose weekly isoniazid and rifapentine course for South Korean healthcare workers.

Respir Med 2019 Oct - Nov;158:42-48. Epub 2019 Oct 7.

Division of Pulmonology and Critical Care Medicine, Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea. Electronic address:

Purpose: We investigated the adverse events (AEs) and treatment completion rates of a 3 month course of once-weekly isoniazid and rifapentine (3HP) in South Korean health care workers (HCWs) with latent tuberculosis infection (LTBI).

Methods: HCWs who were candidates for LTBI treatment were enrolled from two tertiary referral centers between December 2016 and October 2017. From December 2016 through March 2017, HCWs who agreed were treated with the 3HP regimen (3HP group). Read More

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http://dx.doi.org/10.1016/j.rmed.2019.10.005DOI Listing
October 2019
1 Read

Determinants of alcohol use among people living with HIV initiating isoniazid preventive therapy in Ethiopia.

Drug Alcohol Depend 2019 Nov 30;204:107465. Epub 2019 Aug 30.

ICAP at Columbia University, Mailman School of Public Health, Columbia University, New York, NY, USA; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA. Electronic address:

Background: Hepatotoxicity, an adverse effect of isoniazid preventative therapy (IPT), is exacerbated by alcohol consumption. Although the WHO recommends IPT for people living with HIV (PLHIV), it is contraindicated in regular alcohol users. The objective of this study was to identify the prevalence and determinants of alcohol use among PLHIV initiating IPT in Ethiopia. Read More

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http://dx.doi.org/10.1016/j.drugalcdep.2019.04.036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6948347PMC
November 2019
10 Reads

Does hepatotoxicity interfere with endocrine activity in zebrafish (Danio rerio)?

Chemosphere 2020 Jan 14;238:124589. Epub 2019 Aug 14.

Aquatic Ecology and Toxicology Section, Centre for Organismal Studies, University of Heidelberg, Im Neuenheimer Feld 504, D-69120, Heidelberg, Germany.

Vitellogenin (VTG), a well-established biomarker for the diagnosis of endocrine activity in fish, is used in multiple OECD test guidelines (TG) to identify activities of chemicals on hormonal pathways. However, the synthesis of VTG may not only be modified by typical endocrine-related pathways, but also through non-endocrine-mediated processes. In particular, hepatotoxicity, i. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2019.124589DOI Listing
January 2020
2 Reads
3.340 Impact Factor

Mitochondrial DNA Variants in Patients with Liver Injury Due to Anti-Tuberculosis Drugs.

J Clin Med 2019 Aug 13;8(8). Epub 2019 Aug 13.

Department of Internal Medicine, National Taiwan University Hospital, Taipei 10002, Taiwan.

Background: Hepatotoxicity is the most severe adverse effect of anti-tuberculosis therapy. Isoniazid's metabolite hydrazine is a mitochondrial complex II inhibitor. We hypothesized that mitochondrial DNA variants are risk factors for drug-induced liver injury (DILI) due to isoniazid, rifampicin or pyrazinamide. Read More

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http://dx.doi.org/10.3390/jcm8081207DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6723168PMC
August 2019
2 Reads

Additional compounds and the therapeutic potential of Cnidoscolus chayamansa (McVaugh) against hepatotoxicity induced by antitubercular drugs.

Biomed Pharmacother 2019 Sep 4;117:109140. Epub 2019 Jul 4.

Unidad de Investigación Médica (UIM) en Farmacología, UMAE Hospital de Especialidades, CORSE 2º piso, Centro Médico Nacional Siglo XXI (CMN-SXXI), Instituto Mexicano del Seguro Social (IMSS), Av. Cuauhtémoc 330, Col. Doctores, 06720, Ciudad de México (CDMX), Mexico. Electronic address:

Previously non-isolated compounds (scopoletin and β-D-Glucopyranoside, (1R)-O-isopropyl 6-O-(2,3,4-tri-O-acetyl-β-D-xylopyranosyl)-2,3,4-triacetate) were isolated from an organic extract of the Cnidoscolus chayamansa stem. Also, lupeol acetate (main compound, 49.7 mg/g of dry extract) and scopoletin (0. Read More

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http://dx.doi.org/10.1016/j.biopha.2019.109140DOI Listing
September 2019
2 Reads

A comparison of hepatoprotective activity of Bacoside to Silymarin treatment against a combined Isoniazid and Rifampin-induced hepatotoxicity in female Wistar rats.

J Histotechnol 2019 09 4;42(3):128-136. Epub 2019 Aug 4.

Department of Biochemistry, Bharathi Women's College , Chennai , Tamil Nadu , India.

The liver is an important organ that plays a vital role in homeostasis maintenance and regulation. Any liver damage or injury caused by drugs or chemicals is called hepatotoxicity. Isoniazid and rifampin are drugs used separately to treat tuberculosis but have unique side effects and potential hepatotoxicity. Read More

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http://dx.doi.org/10.1080/01478885.2019.1638535DOI Listing
September 2019
9 Reads
0.306 Impact Factor

Hepatotoxicity and virological breakthrough of HCV following treatment with sofosbuvir, daclatasvir, and ribavirin in patients previously treated for tuberculosis.

Authors:
Braira Wahid

J Med Virol 2019 12 5;91(12):2195-2197. Epub 2019 Aug 5.

Department of Life Sciences, School of Science, University of Management and Technology, Lahore, Punjab, Pakistan.

The prevalence of hepatitis C virus/tuberculosis (HCV/TB) coinfection has not been estimated globally but few studies highlight the risk of hepatotoxicity following TB treatment or HCV treatment. Previously reported data highlights the risk of drug-induced hepatotoxicity associated with three of the first-line anti-TB agents: rifampin, isoniazid, and pyrazinamide specifically in patients coinfected with HIV and HCV. Thus far, direct-acting antiviral (DAA) drug-induced hepatotoxicity has not been reported in the literature but herein, we observed an unusual case of HCV virological breakthrough and hepatoxicity during treatment with DAA drugs in a patient who has previously been successfully treated for TB. Read More

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http://dx.doi.org/10.1002/jmv.25557DOI Listing
December 2019
2 Reads
2.347 Impact Factor

Prominence of Oxidative Stress in the Management of Anti-tuberculosis Drugs Related Hepatotoxicity.

Drug Metab Lett 2019 ;13(2):95-101

Department of Pharmacology, SVKM's Dr. Bhanuben Nanavati College of Pharmacy, Vile Parle, Mumbai-400056, Maharashtra, India.

Advanced medical services and treatments are available for treating Tuberculosis. Related prevalence has increased in recent times. Unfortunately, the continuous consumption of related drugs is also known for inducing hepatotoxicity which is a critical condition and cannot be overlooked. Read More

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http://dx.doi.org/10.2174/1872312813666190716155930DOI Listing
May 2020
2 Reads

Quercetin protected against isoniazide-induced HepG2 cell apoptosis by activating the SIRT1/ERK pathway.

J Biochem Mol Toxicol 2019 Sep 23;33(9):e22369. Epub 2019 Jul 23.

Department of Pharmacy, the First Hospital of Jilin University, Changchun, China.

Isoniazid (INH) is one of the most commonly used antituberculosis drugs, but its clinical applications have been limited by severe hepatic toxicity. Quercetin (Que), a natural flavonoid, has been proved to have many medicinal properties. This study aimed to clarify the possible protective effects of Que against INH-induced hepatotoxicity using HepG2 cells. Read More

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http://dx.doi.org/10.1002/jbt.22369DOI Listing
September 2019
4 Reads

New isoniazid derivatives with improved pharmaco-toxicological profile: Obtaining, characterization and biological evaluation.

Eur J Pharm Sci 2019 Sep 26;137:104974. Epub 2019 Jun 26.

University of Medicine and Pharmacy Grigore T. Popa, Faculty of Medicine, Department of Histology, 16 Universitatii Str., 700115, Iasi, Romania.

Tuberculostatic drugs are the most common drug groups with global hepatotoxicity. Awareness of potentially severe hepatotoxic reactions is vital, as hepatic impairment can be a devastating and often fatal condition. The treatment problems that may arise, within this class of medicines, are mainly of two types: adverse reactions (collateral, toxic or hypersensitive reactions) and the initial or acquired resistance of Mycobacterium tuberculosis to one or more antituberculosis drugs. Read More

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http://dx.doi.org/10.1016/j.ejps.2019.104974DOI Listing
September 2019
8 Reads

Correction for Zhang et al., "Hepatotoxicity Induced by Isoniazid-Lipopolysaccharide through Endoplasmic Reticulum Stress, Autophagy, and Apoptosis Pathways in Zebrafish".

Antimicrob Agents Chemother 2019 Jul 24;63(7). Epub 2019 Jun 24.

Biology Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan, Shandong Province, People's Republic of China

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http://dx.doi.org/10.1128/AAC.00936-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6591627PMC
July 2019
7 Reads

Prophylaxis for Tuberculosis in Pregnant Women.

Clin Obstet Gynecol 2019 12;62(4):846-856

Sarasota Memorial Health Care System Pharmacy Department.

As more women at increased risk for tuberculosis (TB) reactivation immigrate to the United States, perinatal screening and chemoprophylaxis are increasingly important. Interferon-gamma release assays and the tuberculin skin test are acceptable screening tests with the latter supported by more data in pregnancy. Women screening positive should have active TB excluded, and if negative, latent TB is likely. Read More

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http://dx.doi.org/10.1097/GRF.0000000000000465DOI Listing
December 2019
8 Reads

Short-course treatment outcomes and adverse events in adults and children-adolescents with MDR-TB in Niger.

Int J Tuberc Lung Dis 2019 05;23(5):625-630

Damien Foundation, Niamey, Niger, International Union Against Tuberculosis and Lung Disease, Paris, France.

SETTING Niger National Tuberculosis Programme. OBJECTIVE To describe the outcomes and adverse events (AEs) in a cohort of adults, children and adolescents with multidrug-resistant tuberculosis (MDR-TB) who were treated with the 'short-course regimen'. DESIGN The regimen comprised an intensive phase of 4-6 months with kanamycin, medium-high dose of isoniazid and prothionamide, and high doses of gatifloxacin, clofazimine, ethambutol and pyrazinamide throughout. Read More

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http://dx.doi.org/10.5588/ijtld.17.0871DOI Listing
May 2019
6 Reads

N-acetyltransferase: the practical consequences of polymorphic activity in man.

Xenobiotica 2020 Jan 4;50(1):77-91. Epub 2019 Jun 4.

Section of Computational and Systems Medicine, Faculty of Medicine, Imperial College London, London, UK.

Over the years, numerous studies have supported the premise that individuals possessing the "slow acetylator" phenotype are more at risk from developing drug side-effects. Most prominent amongst these reports are those concerned with hepatotoxicity and peripheral neuropathy following treatment with isoniazid, lupus-like symptoms during procainamide therapy and experiencing hypersensitivity reactions to the various sulphonamide derivatives. Similarly, "slow acetylators" undergoing heavy exposure to arylamines and related carcinogens are more likely to develop bladder cancer. Read More

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http://dx.doi.org/10.1080/00498254.2019.1618511DOI Listing
January 2020
13 Reads

Pharmacokinetics of isoniazid: The good, the bad, and the alternatives.

Tuberculosis (Edinb) 2019 05 26;116S:S66-S70. Epub 2019 Apr 26.

Biology Department, University of St. Thomas, Houston, TX 77006, USA. Electronic address:

Although isoniazid (INH) has been successful in treating Tuberculosis (TB) since its introduction in 1952, there has been continual reports of drug-associated hepatotoxicity in TB patients. These toxic side effects may reveal more about the recipient of the drug, than the drug itself. A combination of pharmacogenetic and pharmacokinetic studies have identified polymorphisms within enzymes involved in INH metabolism and detoxification. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S14729792193015
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http://dx.doi.org/10.1016/j.tube.2019.04.012DOI Listing
May 2019
33 Reads

Completion Rates, Adverse Effects, and Costs of a 3-Month and 9-Month Treatment Regimen for Latent Tuberculosis Infection in California Inmates, 2011-2014.

Public Health Rep 2019 May/Jun;134(1_suppl):71S-79S

1 Medical Services Division, Public Health Branch, California Correctional Health Care Services, Elk Grove, CA, USA.

Objectives: In California, about 80% of tuberculosis disease is caused by untreated latent tuberculosis infection (LTBI), and the rate of LTBI is higher among incarcerated persons (16%) than among nonincarcerated persons (6%). We compared 2 regimens to treat LTBI in an adult prison population in California: 9 months of twice-weekly isoniazid (9H; previous standard of care) and 12 once-weekly doses of isoniazid and rifapentine (3HP; introduced in 2011).

Methods: We evaluated the rates of completion and discontinuation caused by hepatotoxicity among randomly selected patients with LTBI prescribed the 9H regimen in 2011 and among patients with LTBI prescribed the 3HP regimen who entered California prisons during September 2013-March 2014. Read More

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http://dx.doi.org/10.1177/0033354919826557DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6505317PMC
October 2019
8 Reads

Mechanism of isoniazid-induced hepatotoxicity in zebrafish larvae: Activation of ROS-mediated ERS, apoptosis and the Nrf2 pathway.

Chemosphere 2019 Jul 6;227:541-550. Epub 2019 Apr 6.

Biology Institute, Qilu University of Technology (Shandong Academy of Sciences), Key Laboratory for Drug Screening Technology of Shandong Academy of Sciences, Key Laboratory for Biosensor of Shandong Province, Jinan, Shandong Province, PR China. Electronic address:

Isoniazid (INH) is a first-line anti-tuberculosis drug. INH has been detected in surface waters which may create a risk to aquatic organisms. In this study, the hepatotoxicity of INH was elucidated using zebrafish. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00456535193067
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http://dx.doi.org/10.1016/j.chemosphere.2019.04.026DOI Listing
July 2019
38 Reads

Multifocal Osteomyelitic Tuberculosis at Rare Locations with Metastatic Tuberculosis Abscess.

Am J Case Rep 2019 Apr 12;20:503-507. Epub 2019 Apr 12.

Department of Dermato-Venerology, Universitas Padjadjaran - Hasan Sadikin General Hospital, Bandung, West Java, Indonesia.

BACKGROUND Multifocal tuberculosis (TB) with more than 1 tuberculous osteoarticular lesion is rare. Furthermore, metastatic tuberculous abscess (MTA) is also a very rare manifestation of cutaneous TB in children. A non-specific, often subtle, early clinical presentation in conjunction with a low prevalence rate constitute obstacles for diagnosis. Read More

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http://dx.doi.org/10.12659/AJCR.913615DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6474155PMC
April 2019
20 Reads

Mitochondrial Damage and Drp1 Overexpression in Rifampicin- and Isoniazid-induced Liver Injury Cell Model.

J Clin Transl Hepatol 2019 Mar 15;7(1):40-45. Epub 2019 Mar 15.

Department of Liver Diseases, Third Hospital of Shenzhen, Shenzhen, Guangdong, China.

Rifampicin (RFP) and isoniazid (INH) are widely used as anti-tuberculosis agents. However, the mechanisms underlying the involvement of reactive oxygen species and mitochondria in RFP- and INH-related hepatotoxicity have not been established yet. This study aimed to observe the intracellular mechanisms leading to mitochondrial dysfunction and morphological changes in RFP- and INH-induced hepatocyte injury. Read More

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http://dx.doi.org/10.14218/JCTH.2018.00052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441640PMC
March 2019
33 Reads

Mitochondrial dysfunction as a mechanism of drug-induced hepatotoxicity: current understanding and future perspectives.

J Clin Transl Res 2018 May 28;4(1):75-100. Epub 2018 May 28.

Department of Pharmacology, Toxicology & Therapeutics, University of Kansas Medical Center, Kansas City, KS, United States.

Mitochondria are critical cellular organelles for energy generation and are now also recognized as playing important roles in cellular signaling. Their central role in energy metabolism, as well as their high abundance in hepatocytes, make them important targets for drug-induced hepatotoxicity. This review summarizes the current mechanistic understanding of the role of mitochondria in drug-induced hepatotoxicity caused by acetaminophen, diclofenac, anti-tuberculosis drugs such as rifampin and isoniazid, anti-epileptic drugs such as valproic acid and constituents of herbal supplements such as pyrrolizidine alkaloids. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261533PMC
May 2018
17 Reads

High-dose rifampicin in tuberculosis: Experiences from a Dutch tuberculosis centre.

PLoS One 2019 14;14(3):e0213718. Epub 2019 Mar 14.

Department of Pulmonary Diseases, Radboud University Medical Center-Dekkerswald, Nijmegen, The Netherlands.

Background: Recent evidence suggests that higher rifampicin doses may improve tuberculosis (TB) treatment outcome.

Methods: In this observational cohort study we evaluated all TB patients who were treated with high-dose rifampicin (> 10 mg/kg daily) in our reference centre, from January 2008 to May 2018. Indications, achieved plasma rifampicin exposures, safety and tolerability were evaluated. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0213718PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417786PMC
December 2019
8 Reads
3.234 Impact Factor

Hepatotoxicity Induced by Isoniazid-Lipopolysaccharide through Endoplasmic Reticulum Stress, Autophagy, and Apoptosis Pathways in Zebrafish.

Antimicrob Agents Chemother 2019 05 25;63(5). Epub 2019 Apr 25.

Biology Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan, Shandong Province, People's Republic of China

Isoniazid (INH) is a first-line antituberculosis drug. The incidence of adverse reactions accompanied by inflammation in the liver during drug administration to tuberculosis patients is high and severely affects clinical treatment. To better understand the mechanism of hepatotoxicity induced by INH under the inflammatory state, we compared the differences in levels of hepatotoxicity from INH between normal zebrafish and zebrafish in an inflammatory state to elucidate the hepatotoxic mechanism using different endpoints such as mortality, malformation, inflammatory effects, liver morphology, histological changes, transaminase analysis, and expression levels of certain genes. Read More

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http://dx.doi.org/10.1128/AAC.01639-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6496066PMC
May 2019
11 Reads

Window Period Prophylaxis for Children Exposed to Tuberculosis, Houston, Texas, USA, 2007-2017.

Emerg Infect Dis 2019 03;25(3):523-528

In this retrospective study, we assessed the safety of window period prophylaxis and proportion of tuberculin skin test (TST) conversions in children <5 years of age who were exposed to an adult with tuberculosis disease during 2007-2017. Children included in this study had unremarkable examination and chest radiograph findings and negative test results for TB infection. In total, 752 children (41% cohabitating with the index patient) received prophylaxis during the window period, usually directly observed therapy with isoniazid. Read More

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http://dx.doi.org/10.3201/eid2503.181596DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390765PMC
March 2019
9 Reads