BMC Cardiovasc Disord 2021 Feb 2;21(1):68. Epub 2021 Feb 2.
Immunology Research Center (IRC), Institute of Immunology and Infectious Disease, Iran University of Medical Sciences, Shahid Hemmat Highway 14496, Tehran, Iran.
Background: Coronary artery disease (CAD) is characterized by narrowing/ blockade of coronary arteries that is mainly caused by atherosclerotic plaques. Considering the involvement of platelet abnormalities, such as defective aggregation and adhesion, in the cardiovascular-related disorders, genetic variations in human platelet alloantigens (HPA) have been implicated in the CAD susceptibility. Herein, we intended to determine the association of HPA-1 to -6, -9, and -15 biallelic polymorphisms with CAD in an Iranian population. Read More