13,164 results match your criteria Irritable Bowel Syndrome


The Relation between Dietary Patterns and Functional Gastrointestinal Disorders among Iranian Military Men.

Adv Biomed Res 2019 21;8. Epub 2019 Jan 21.

Modern Epidemiology Research Center, AJA University of Medical Sciences, Tehran, Iran.

Background: Assessing the relation between dietary habits and functional gastrointestinal disorders (FGIDs) is less investigated among military personnel. In this study, we aimed to evaluate the association of certain eating patterns and FGIDs in Iranian army men.

Materials And Methods: This cross-sectional study was performed on 600 army personnel working in Kerman ground forces military station number 05, Iran. Read More

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http://dx.doi.org/10.4103/abr.abr_180_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357671PMC
January 2019

Effect of Irritable Bowel Syndrome on Sleep Quality and Quality of Life of Inflammatory Bowel Disease in Clinical Remission.

Int J Prev Med 2019 15;10:10. Epub 2019 Jan 15.

Department of Internal Medicine, Metabolic Diseases Research Center, Qazvin University of Medical Sciences, Qazvin, Iran.

Background: Inflammatory bowel disease (IBD) as a chronic and debilitating disease is affected by sleep disturbance which increases the risk of malignancy. Sleep disturbance is more common in irritable bowel syndrome (IBS) and few reported studies have assessed its role in IBD. We evaluated the effect of IBS on sleep quality and quality of life (QOL) of IBD patients in clinical remission. Read More

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http://dx.doi.org/10.4103/ijpvm.IJPVM_364_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360848PMC
January 2019

Dietary fiber and risk of irritable bowel syndrome: a case-control study.

Gastroenterol Hepatol Bed Bench 2018 ;11(Suppl 1):S20-S24

Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Aim: The purpose of this study was to determine the relationship between dietary fiber intake and risk of irritable bowel syndrome (IBS).

Background: Patients with IBS are usually concerned about their diet, which can exacerbate or relieve their symptoms.

Methods: In this case-control study, ninety cases and 355 controls were selected from a gastroenterology clinic. Read More

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January 2018

Profile of plecanatide in the treatment of chronic idiopathic constipation: design, development, and place in therapy.

Clin Exp Gastroenterol 2019 22;12:31-36. Epub 2019 Jan 22.

Division of Gastroenterology and Hepatology, Department of Medicine, Medical College of Georgia, Augusta University, Augusta, GA, USA,

Constipation is a multifactorial disorder that can cause significant psychological distress to patients and economic burden on the health care system. Many patients are not satisfied with their current established treatment, highlighting the need for new and improved therapeutic options. Guanylate cyclase-C (GC-C)/cyclic guanosine monophosphate agonists have emerged as a safe and efficacious class of drugs for the treatment of chronic idiopathic constipation (CIC). Read More

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http://dx.doi.org/10.2147/CEG.S145668DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348976PMC
January 2019

Contribution of ghrelin to functional gastrointestinal disorders' pathogenesis.

World J Gastroenterol 2019 Feb;25(5):539-551

Department of Basic Medical Science, Laboratory of Biology, School of Medicine, University of Athens, Athens 11527, Greece.

Functional gastrointestinal disorders (FGID) are heterogeneous disorders with a variety of clinical manifestations, primarily defined by signs and symptoms rather than a definite underlying cause. Their pathophysiology remains obscure and, although it is expected to differ according to the specific FGID, disruptions in the brain-gut axis are now thought to be a common denominator in their pathogenesis. The hormone ghrelin is an important component of this axis, exerting a wide repertoire of physiological actions, including regulation of gastrointestinal motility and protection of mucosal tissue. Read More

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http://dx.doi.org/10.3748/wjg.v25.i5.539DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371003PMC
February 2019

The impact of allergic rhinitis on gastrointestinal disorders among young adults.

J Eval Clin Pract 2019 Feb 17. Epub 2019 Feb 17.

School of Medicine, Chung Shan Medical University, Taichung, Taiwan.

Background: An association between allergic rhinitis (AR) and digestive diseases (DDs) has been reported; however, studies have only focused on the prevalence of DDs in populations of patients with AR. In individuals with specific DDs, the impact of AR on the frequency of clinical visits for each DD has not been studied. Moreover, the association between topical steroid usage for AR and DDs has not been investigated. Read More

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http://dx.doi.org/10.1111/jep.13108DOI Listing
February 2019

Mucosal RNA and Protein Expression as the next frontier in IBS: abnormal function despite morphologically intact small intestinal Mucosa.

Am J Physiol Gastrointest Liver Physiol 2019 Feb 15. Epub 2019 Feb 15.

University Hospital Vall d'Hebron, Barcelona.

Irritable bowel syndrome is one of the commonest gastrointestinal disorders. Although long-time considered a pure functional disorder, intense research in past years has rendered a very complex and varied array of observations indicating the presence of structural and molecular abnormalities underlying characteristic motor and sensitive changes and clinical manifestations. Analysis of gene and protein expression in the intestinal mucosa has shed light on the molecular mechanisms implicated in IBS physiopathology. Read More

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http://dx.doi.org/10.1152/ajpgi.00186.2018DOI Listing
February 2019

Quality of life and its association with irritable bowel syndrome and fatigue ten years after giardiasis.

Neurogastroenterol Motil 2019 Feb 14:e13559. Epub 2019 Feb 14.

Research Unit for General Practice, NORCE Norwegian Research Centre, Bergen, Norway.

Background: Gastroenteritis has been associated with complications such as irritable bowel syndrome (IBS) and chronic fatigue (CF). Little is known about the implications for quality of life (QoL) in this setting. The aims of this study were to evaluate the association between exposure to Giardia infection and QoL ten years after the infection, and how this related to IBS and CF. Read More

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http://dx.doi.org/10.1111/nmo.13559DOI Listing
February 2019

Alterations in fecal short-chain fatty acids in patients with irritable bowel syndrome: A systematic review and meta-analysis.

Medicine (Baltimore) 2019 Feb;98(7):e14513

Department of Gastroenterology, Peking University Third Hospital, No. 49 North Garden Rd., Haidian District, Beijing, 100191, China.

Background: Recent studies indicate that gut microbiota disorders potentially contribute to the pathogenesis of irritable bowel syndrome (IBS), which can be partly reflected by fecal short-chain fatty acids (SCFAs) generated from gut microbiota. Previous studies on SCFA alterations in patients with IBS have yielded conflicting results. No prior systematic review has been conducted on the alterations in fecal SCFAs in IBS patients. Read More

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http://dx.doi.org/10.1097/MD.0000000000014513DOI Listing
February 2019

The overlap of irritable bowel syndrome and noncoeliac gluten sensitivity.

Curr Opin Gastroenterol 2019 Feb 12. Epub 2019 Feb 12.

Academic Unit of Gastroenterology, Royal Hallamshire Hospital, Sheffield Teaching Hospital NHS Foundation Trust.

Purpose Of Review: There has been significant interest in gluten over the last decade, with an increase in interest of gluten-related disorders outside coeliac disease. Particularly, there has been a focus on the role of gluten in noncoeliac gluten sensitivity (NCGS) and irritable bowel syndrome (IBS). There is significant overlap between both of these conditions, with the aim of this review to explore their complex relationship. Read More

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http://dx.doi.org/10.1097/MOG.0000000000000517DOI Listing
February 2019

Submucosal Lipomas Causing Intussusception and Small Bowel Obstruction: A Case Report.

Cureus 2018 Dec 5;10(12):e3692. Epub 2018 Dec 5.

Surgery, Riverside Community Hospital, Riverside, USA.

Intussusception is a rare cause of bowel obstruction caused by both benign and malignant pathology. We are presenting the case of an elderly patient who had been diagnosed with irritable bowel syndrome for many years prior to presenting to us with ileocecal intussusception causing a small bowel obstruction. Laparoscopic resection of the terminal ileum and cecum was performed. Read More

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https://www.cureus.com/articles/15771-submucosal-lipomas-cau
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http://dx.doi.org/10.7759/cureus.3692DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368428PMC
December 2018
1 Read

The Impact of Low-FODMAPs, Gluten-Free, and Ketogenic Diets on Gut Microbiota Modulation in Pathological Conditions.

Nutrients 2019 Feb 12;11(2). Epub 2019 Feb 12.

Human Microbiome Unit, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.

The gut microbiota performs several essential protective, structural, and metabolic functions for host health. The maintenance of a beneficial microbiota requires a homeostatic equilibrium within microbial communities, and between the microorganisms and the host. The gut microbiota composition may be affected by external factors, among them diet habits may be considered most important. Read More

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http://dx.doi.org/10.3390/nu11020373DOI Listing
February 2019

Comparison of Serum Vitamin D Levels in Relation to Bowel and Bladder Symptoms in Women with Vulvar Diseases.

Int J Vitam Nutr Res 2019 Feb 12:1-7. Epub 2019 Feb 12.

1 Michigan Medicine Department of Obstetrics and Gynecology, 1500 E. Medical Center Dr., Ann Arbor, MI 48109, 734-647-9727 (fax).

Objectives: We sought to investigate associations between vitamin D levels and bowel and bladder disorders in women with vulvar diseases.

Methods: This is a planned sub-analysis of a cross-sectional study comparing the prevalence of bowel and bladder symptoms in women with biopsy-proven vulvar lichen sclerosus (LS) to a control group of women with non-lichenoid vulvar diseases. All subjects were recruited from a tertiary referral vulvar care clinic in a university-based practice. Read More

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http://dx.doi.org/10.1024/0300-9831/a000527DOI Listing
February 2019
1 Read

Overlapping irritable bowel syndrome and inflammatory bowel disease.

Minerva Gastroenterol Dietol 2019 Feb 11. Epub 2019 Feb 11.

Division of Gastroenterology and Hepatology, Lynda K. and David M. Underwood Center for Digestive Disorders, Houston Methodist Hospital and Weill Cornell Medical College, Houston, TX, USA -

The pathogenesis of irritable bowel-type symptoms occurring in patients with inflammatory bowel disease who are in apparent remission continues to generate scientific controversy and the interpretation and management of these symptoms, so distressing to the sufferer, represent major challenges for the clinician. On the one hand, these symptoms often satisfy Rome IV criteria for IBS and their occurrence correlates highly with anxiety, a known trigger for IBS. On the other hand, recent studies have shown that many of these patients exhibit subtle inflammatory changes. Read More

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https://www.minervamedica.it/index2.php?show=R08Y9999N00A190
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http://dx.doi.org/10.23736/S1121-421X.19.02559-5DOI Listing
February 2019
2 Reads

Irritable bowel syndrome: a picture of the US real world.

Minerva Gastroenterol Dietol 2019 Feb 11. Epub 2019 Feb 11.

Unit of Gastroenterology, Molinette Hospital, Turin, Italy -

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http://dx.doi.org/10.23736/S1121-421X.19.02558-3DOI Listing
February 2019

Thirty Years of Lactobacillus rhamnosus GG: A Review.

Authors:
Lucio Capurso

J Clin Gastroenterol 2019 Mar;53 Suppl 1:S1-S41

Department of Gastroenterology, San Filippo Neri Hospital, Rome, Italy.

Lactobacillus rhamnosus GG (LGG) was the first strain belonging to the genus Lactobacillus to be patented in 1989 thanks to its ability to survive and to proliferate at gastric acid pH and in medium containing bile, and to adhere to enterocytes. Furthermore LGG is able to produces both a biofilm that can mechanically protect the mucosa, and different soluble factors beneficial to the gut by enhancing intestinal crypt survival, diminishing apoptosis of the intestinal epithelium, and preserving cytoskeletal integrity. Moreover LGG thanks to its lectin-like protein 1 and 2 inhibits some pathogens such as Salmonella species. Read More

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http://dx.doi.org/10.1097/MCG.0000000000001170DOI Listing
March 2019
1 Read

Metformin prevents colonic barrier dysfunction by inhibiting mast cell activation in maternal separation-induced IBS-like rats.

Neurogastroenterol Motil 2019 Feb 10:e13556. Epub 2019 Feb 10.

Laboratory of Neuronal Network and Systems Biology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, China.

Background: Intestinal barrier dysfunction is a key etiologic factor of irritable bowel syndrome (IBS). Metformin improves intestinal barrier function, although the underlying mechanism has yet to be fully explained. This study evaluates the protective effect of metformin on colonic barrier integrity and explores the underlying cellular mechanisms. Read More

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http://dx.doi.org/10.1111/nmo.13556DOI Listing
February 2019
1 Read

Bile and fat excretion are biomarkers of clinically significant diarrhoea and constipation in irritable bowel syndrome.

Aliment Pharmacol Ther 2019 Feb 10. Epub 2019 Feb 10.

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota.

Background: Biomarkers in irritable bowel syndrome (IBS) may guide targeted therapy in this multifactorial disease. It has been suggested that 75% accuracy and cost <$500 categorise biomarkers as cost-effective.

Aim: To identify differences in faecal bile acids, faecal fat and fasting serum C4 (7a-hydroxy-4-cholesten-3-one) and fibroblast growth factor 19 (FGF19) among patients with IBS-D, IBS-C and healthy controls and to determine accurate, cost-effective biomarkers for clinically relevant diarrhoea and constipation. Read More

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http://dx.doi.org/10.1111/apt.15106DOI Listing
February 2019
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Opportunities for reducing emergency diagnoses of colon cancer in women and men: A data-linkage study on pre-diagnostic symptomatic presentations and benign diagnoses.

Eur J Cancer Care (Engl) 2019 Feb 8:e13000. Epub 2019 Feb 8.

Cancer Survival Group, Department of Non-communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK.

Objectives: To identify opportunities for reducing emergency colon cancer diagnoses, we evaluated symptoms and benign diagnoses recorded before emergency presentations (EP).

Methods: Cohort of 5,745 colon cancers diagnosed in England 2005-2010, with individually linked cancer registry and primary care data for the 5-year pre-diagnostic period.

Results: Colon cancer was diagnosed following EP in 34% of women and 30% of men. Read More

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http://dx.doi.org/10.1111/ecc.13000DOI Listing
February 2019
1 Read

[The Role of Psychotherapy in the Treatment of Irritable Bowel Syndrome].

Psychother Psychosom Med Psychol 2019 Feb 7. Epub 2019 Feb 7.

Medizinische Klinik mit Schwerpunkt Psychosomatik, Charité-Universitätsmedizin Berlin.

Irritable bowel syndrome is a common functional gastrointestinal disorder that greatly impacts on quality of life due to gastrointestinal complaints such as pain or altered stool habits. Based on the biopsychosocial model the severity of the disease is affected by the combination of physiological processes, social aspects and psychological factors. While treatment approaches mainly focused on the reduction of gut complaints by dietary means or medication, psychotherapy is becoming an alternative or additional approach with very good evidence, especially in light of associated psychiatric comorbidities (e. Read More

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http://dx.doi.org/10.1055/a-0829-6990DOI Listing
February 2019

[Sensitivity and Specificity of the Reizdarm-Fragebogen].

Psychother Psychosom Med Psychol 2019 Feb 7. Epub 2019 Feb 7.

Abt. Psychosomatik und Verhaltenstherapie, Rehazentrum Seehof der Deutschen Rentenversicherung, Teltow.

Background: The Reizdarm-Fragebogen (RDF) is the first German questionnaire to assess subjectively perceived symptom severity of irritable bowel syndrome (IBS). Thus far, this was only possible in the context of a medical examination by a practitioner. The goal of the current study was to assess differences in RDF scores among IBS patients and other clinical and non-clinical populations. Read More

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http://dx.doi.org/10.1055/a-0834-6207DOI Listing
February 2019
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Effects of CPEB1 in the anterior cingulate cortex on visceral pain in mice.

Brain Res 2019 Feb 4. Epub 2019 Feb 4.

Department of Pharmacology, School of Pharmacy, and Precision Pharmacy & Drug Development Center, Department of Pharmacy, Tangdu Hospital, Fourth Military Medical University, Xi'an, 710032, China. Electronic address:

Patients with irritable bowel syndrome suffer from chronic visceral pain, and in some of them, this is accompanied by anxiety comorbidity. Cytoplasmic polyadenylation element binding protein 1 (CPEB1) mediates the cytoplasmic polyadenylation of mRNAs and facilitates their translation. Our previous studies have shown that CPEB1 knockdown in the amygdala exerts anxiolytic but not analgesic effects in a mouse model of inflammatory pain. Read More

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http://dx.doi.org/10.1016/j.brainres.2019.02.001DOI Listing
February 2019
1 Read

Conditioned Pain Modulation (CPM) is Reduced in Irritable Bowel Syndrome: A Systematic Review and Meta-Analysis of CPM and the Role of Psychological Factors.

J Clin Gastroenterol 2019 Feb 5. Epub 2019 Feb 5.

Pain Management Research Institute, Faculty of Medicine and Health.

This systematic review summarises evidence assessing endogenous pain inhibition in people with irritable bowel syndrome (IBS) compared with healthy controls using conditioned pain modulation (CPM) and offset analgesia (OA). Evidence regarding the role of psychological variables is also examined. The review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. Read More

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http://dx.doi.org/10.1097/MCG.0000000000001181DOI Listing
February 2019
1 Read

Continuing Medical Education Questions: February 2019.

Authors:
Ian Lustbader

Am J Gastroenterol 2019 Feb;114(2):200

New York University Langone Health, New York, New York.

To receive CME/MOC credit for this activity, please go to: http://acgjournalcme.gi.org/Article Title: Influence of Dietary Restriction on Irritable Bowel Syndrome. Read More

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http://dx.doi.org/10.14309/ajg.0000000000000128DOI Listing
February 2019

Joint Hypermobility Among Female Patients Presenting with Chronic Myofascial Pelvic Pain.

PM R 2019 Feb 6. Epub 2019 Feb 6.

Department of Obstetrics and Gynecology, Denver Health Medical Center, Denver, CO.

Background: Female chronic pelvic pain is estimated to affect up to 24% of adult women, many of whom have a component of myofascial pelvic pain. Although an association of joint hypermobility and pelvic pain has been hypothesized, limited data are available that estimate the prevalence of joint hypermobility in this population.

Objective: To estimate the prevalence of generalized hypermobility spectrum disorder (G-HSD) among female patients with chronic myofascial pelvic pain and examine the association between G-HSD and other frequent pelvic pain-associated complaints. Read More

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http://dx.doi.org/10.1002/pmrj.12131DOI Listing
February 2019
2 Reads

Sex-related differences in resting-state brain activity and connectivity in the orbital frontal cortex and insula in patients with functional constipation.

Neurogastroenterol Motil 2019 Feb 6:e13566. Epub 2019 Feb 6.

Center for Brain Imaging, School of Life Science and Technology, Xidian University, Xi'an, China.

Functional magnetic resonance imaging (fMRI) has been used to investigate sex-related differences in brain abnormalities in patients with irritable bowel syndrome (IBS). Like IBS, women with functional constipation (FC) are 2.1 times as many as men. Read More

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http://dx.doi.org/10.1111/nmo.13566DOI Listing
February 2019
1 Read
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Evaluation of subclinical gut inflammation using fecal calprotectin levels and colonic mucosal biopsy in psoriasis and psoriatic arthritis patients.

Br J Dermatol 2019 Feb 6. Epub 2019 Feb 6.

Gastroenterology, India.

Relationship between the joint disease and the gut inflammation has been established in axial spondyloarthritis(SpA). However this is not well established in Psoriatic arthritis(PsA). Our aim was to compare gut inflammation in psoriasis (PsO), PsA and irritable bowel syndrome(IBS) using fecal calprotectin assay which is a non-invasive tool. Read More

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http://dx.doi.org/10.1111/bjd.17745DOI Listing
February 2019
1 Read

Dietary-induced modulation of the hindgut microbiota is related to behavioral responses during stressful events in horses.

Physiol Behav 2019 Feb 3;202:94-100. Epub 2019 Feb 3.

Univ. Bourgogne Franche-Comté, AgroSup Dijon, PAM UMRA 02.102, F-21000 Dijon, France.

The bidirectional communication between the central and the enteric nervous system named the gut-brain axis has been widely recognized. The gut microbiota has been implicated in a variety of stress-related conditions including anxiety, depression and irritable bowel syndrome based on rodent studies or correlative analysis in human patients. The aim of the present study was to investigate to what extent changes in behavior during stressful events and in the microbial composition of the colonic ecosystem were associated in horses. Read More

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http://dx.doi.org/10.1016/j.physbeh.2019.02.003DOI Listing
February 2019
1 Read

Presence of Irritable Bowel Syndrome Symptoms in Quiescent Inflammatory Bowel Disease Is Associated with High Rate of Anxiety and Depression.

Dig Dis Sci 2019 Feb 6. Epub 2019 Feb 6.

Medical College of Wisconsin, Milwaukee, WI, USA.

Background: Inflammatory bowel disease (IBD; Crohn's disease, CD and Ulcerative colitis, UC) and irritable bowel syndrome (IBS) have overlapping symptoms. Few prevalence studies of IBS in quiescent IBD have used colonoscopy with histology to confirm inactive disease. The aims were (1) to determine the percentage of IBD patients in deep remission whose persistent IBS-like symptoms (IBD/IBS+) would cause them to be classified as having active disease, based on the calculation of Harvey Bradshaw Index (HBI) or UC disease activity index (UCDAI); (2) to identify demographic and disease characteristics that are associated with IBD/IBS+. Read More

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http://dx.doi.org/10.1007/s10620-019-05488-8DOI Listing
February 2019
2 Reads

Rifaximin for Irritable Bowel Syndrome (IBS) in Gulf War Veterans: Losing the Battle but Winning the War?

Authors:
Lucinda A Harris

Dig Dis Sci 2019 Feb 6. Epub 2019 Feb 6.

Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, 13400 E. Shea Blvd, Scottsdale, AZ, 85259, USA.

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http://dx.doi.org/10.1007/s10620-019-05505-wDOI Listing
February 2019

[Overlapping of functional gastrointestinal disorders in latinamerican schoolchildren and adolescents].

Rev Chil Pediatr 2018 Dec;89(6):726-731

Hospital Infantil de Nicaragua Manuel de Jesus Rivera, Managua, Nicaragua.

Introduction: There are few studies on overlapping Functional Gastrointestinal Disorders (FGIDs).

Objective: To describe the prevalence and possible risk factors in Latin American children (Latam) to present overlapping FGIDs.

Patients And Method: Prevalence study in Latam schoolchildren bet ween 8-18 years of age. Read More

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http://dx.doi.org/10.4067/S0370-41062018005000808DOI Listing
December 2018
1 Read

Clinical Effects and Safety of Tongxieyaofang on Diarrhea Predominant Irritable Bowel Syndrome: A Meta-Analysis of Randomized Trails.

Evid Based Complement Alternat Med 2019 6;2019:4893876. Epub 2019 Jan 6.

Department of Pathology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200001, China.

Tongxieyaofang (TXYF), a prescription originated from traditional Chinese medicine (TCM), has been widely used on treating Diarrhea Predominant Irritable Bowel Syndrome (IBS-D). The purpose of this meta-analysis was to investigate whether TXYF was effective and safe for IBS-D. We searched seven electronic databases including CENTRAL, MEDLINE, PubMed, CNKI, VIP, CBM, and Wanfang Data up to 26 July 2017. Read More

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http://dx.doi.org/10.1155/2019/4893876DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339716PMC
January 2019

A Guide to Treating Irritable Bowel Syndrome While Breastfeeding.

Breastfeed Med 2019 Feb 5. Epub 2019 Feb 5.

Division of Clinical Pharmacy, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California.

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https://www.liebertpub.com/doi/10.1089/bfm.2019.0005
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http://dx.doi.org/10.1089/bfm.2019.0005DOI Listing
February 2019
3 Reads

Intestinal permeability in physiological and pathological conditions: major determinants and assessment modalities.

Eur Rev Med Pharmacol Sci 2019 Jan;23(2):795-810

Area Gastroenterologia ed Oncologia Medica, Dipartimento di Scienze Gastroenterologiche, Endocrino-Metaboliche e Nefro-Urologiche, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.

Intestinal permeability is the property that allows solute and fluid exchange between intestinal lumen and intestinal mucosa. Many factors could have major impact on its regulation, including gut microbiota, mucus layer, epithelial cell integrity, epithelial junction, immune responses, intestinal vasculature, and intestinal motility. Any change among these factors could have an impact on intestinal homeostasis and gut permeability. Read More

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http://dx.doi.org/10.26355/eurrev_201901_16894DOI Listing
January 2019
1 Read

Acupuncture and related therapies for treating irritable bowel syndrome: overview of systematic reviews and network meta-analysis.

Therap Adv Gastroenterol 2019 20;12:1756284818820438. Epub 2019 Jan 20.

Jockey Club School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong.

Background: An overview of systematic reviews (SRs) and a network meta-analysis (NMA) were conducted to evaluate the comparative effectiveness of acupuncture and related therapies used either alone, or as an add-on to other irritable bowel syndrome (IBS) treatments.

Methods: A total of eight international and Chinese databases were searched for SRs of randomized controlled trials (RCTs). The methodological quality of SRs was appraised using the AMSTAR instrument. Read More

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http://dx.doi.org/10.1177/1756284818820438DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348567PMC
January 2019

Cav3.2 calcium channel inhibition: a new target for colonic hypersensitivity associated with low-grade inflammation.

Br J Pharmacol 2019 Feb 4. Epub 2019 Feb 4.

Université Clermont Auvergne, INSERM, NEURO-DOL Basics & Clinical Pharmacology of Pain, F-63000, Clermont-Ferrand, France.

Background And Purpose: Abdominal pain associated with low-grade inflammation is frequently encountered in irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD) during the remission phase. Current treatments are generally weakly effective. Therefore, new therapeutic approaches are needed. Read More

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http://doi.wiley.com/10.1111/bph.14608
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http://dx.doi.org/10.1111/bph.14608DOI Listing
February 2019
5 Reads

Comparison of the metabolomic profiles of irritable bowel syndrome patients with ulcerative colitis patients and healthy controls: new insights into pathophysiology and potential biomarkers.

Aliment Pharmacol Ther 2019 Jan 31. Epub 2019 Jan 31.

Division of Gastroenterology, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada.

Background: Evaluation of the metabolomic profile of patients with irritable bowel syndrome offers an opportunity to identify novel pathophysiological targets and biomarkers that could discriminate this disorder from related conditions.

Aim: To identify potential urinary biomarkers that discriminate irritable bowel syndrome patients from ulcerative colitis patients in remission and healthy controls and to explore the pathophysiology of irritable bowel syndrome using a metabolomic approach.

Methods: Urine samples were collected from 39 irritable bowel syndrome patients, 53 ulcerative colitis patients in clinical remission and 21 healthy controls. Read More

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http://doi.wiley.com/10.1111/apt.15141
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http://dx.doi.org/10.1111/apt.15141DOI Listing
January 2019
4 Reads

Frequency of functional gastrointestinal disorders in children with familial Mediterranean fever.

Clin Rheumatol 2019 Jan 31. Epub 2019 Jan 31.

Department of Pediatric Rheumatology, Cukurova University Faculty of Medicine, Saricam, 01331, Adana, Turkey.

Introduction: Familial Mediterranean fever (FMF) is characterized by self-limiting fever episodes usually accompanied by serositis, arthralgia, and arthritis. Functional gastrointestinal disorders (FGIDs) are diseases in which brain-gut axis and low-grade inflammation take part in pathogenesis. We aimed to study the FGIDs frequencies and possible risk factors for FGIDs in children with FMF. Read More

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http://dx.doi.org/10.1007/s10067-019-04452-1DOI Listing
January 2019
1 Read

Reply to: "The type of dyspepsia is important in the context of patients with irritable bowel syndrome and gastroesophageal reflux disease".

J Formos Med Assoc 2019 Jan 28. Epub 2019 Jan 28.

Department of Medicine, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan; Institute of Medical Sciences, Tzu Chi University, Hualien, Taiwan. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09296646193001
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http://dx.doi.org/10.1016/j.jfma.2019.01.006DOI Listing
January 2019
6 Reads

Plasma Corticotropin-Releasing Factor Receptors and B7-2⁺ Extracellular Vesicles in Blood Correlate with Irritable Bowel Syndrome Disease Severity.

Cells 2019 Jan 30;8(2). Epub 2019 Jan 30.

The Osher Center for Integrative Medicine, University of California, San Francisco, CA 94143, USA.

Extracellular vesicles (EVs) are composed of bilayer membranes that are released by different cell types and are present in bodily fluids, such as blood, urine, and bile. EVs are thought to play a key role in intracellular communication. Based on their size and density, EVs are classified into small, medium, or large EVs. Read More

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http://dx.doi.org/10.3390/cells8020101DOI Listing
January 2019
2 Reads

Differential biomechanical properties of mouse distal colon and rectum innervated by the splanchnic and pelvic afferents.

Am J Physiol Gastrointest Liver Physiol 2019 Jan 31. Epub 2019 Jan 31.

Biomedical Engineering, University of Connecticut, United States.

Visceral pain is one of the principal complaints of patients with Irritable Bowel Syndrome (IBS), and this pain is reliably evoked by mechanical distension/stretch of distal colon and rectum (colorectum). This study focuses on the biomechanics of the colorectum that could play critical roles in mechanical neural encoding. We harvested the distal 30 mm of the colorectum from mice, divided evenly into three 10-mm-long segments (colonic, intermediate and rectal), and conducted biaxial mechanical stretch tests and opening-angle measurements for each tissue segment. Read More

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http://dx.doi.org/10.1152/ajpgi.00324.2018DOI Listing
January 2019

SKYPE HYPNOTHERAPY FOR IRRITABLE BOWEL SYNDROME: Effectiveness and Comparison with Face-to-Face Treatment.

Int J Clin Exp Hypn 2019 Jan-Mar;67(1):69-80

a Neurogastroenterology Unit , Wythenshawe Hospital , Manchester , UK.

Gut-focused hypnotherapy is an effective treatment for irritable bowel syndrome but is not widely available. This study assessed whether providing hypnotherapy by Skype might partially overcome this problem. Using a 50-point or more reduction in the IBS Symptom Severity Score as the primary outcome measure, 65% of subjects responded to Skype hypnotherapy with all other outcomes significantly improving. Read More

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http://dx.doi.org/10.1080/00207144.2019.1553766DOI Listing
February 2019
1 Read

Biomarkers of inflammatory bowel disease activity.

Ter Arkh 2018 Dec;90(12):107-111

A.S. Loginov Moscow Clinical Research and Practical Center of the Department of Health of Moscow, Moscow, Russia.

The review presents data on calprotectin, lactoferrin, leukocytes labeled with isotope indium 111In, calgranulin C and pyruvate kinase type M2 - highly sensitive biomarkers to assess the severity of intestinal inflammation. Their importance in diagnostics, determination of treatment efficiency, including as predictors of recurrence of ulcerative colitis and Crohn's disease is shown. Read More

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http://dx.doi.org/10.26442/00403660.2018.12.000018DOI Listing
December 2018
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The cardiovascular system in patients with functional and inflammatory bowel diseases.

Ter Arkh 2018 Feb;90(2):59-64

A.I. Evdokimov Moscow state medical dental University, Ministry of health of Russia, Moscow, Russia.

Aim: Identification of subclinical and metamanifests state changes of cardiovascular system in patients with functional and inflammatory bow- el diseases (IBD) without a background of cardiac pathology.

Materials And Methods: Was examined 79 patients with colon diseases, 20 patients were diagnosed with irritable bowel syndrome (IBS) with diarrhea, a 37 - undifferentiated colitis (UdC) and 22 patients with ulcerative colitis (UC). As a control group were examined in 50 healthy subjects. Read More

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http://ter-arkhiv.ru/en/archive/2018/vol-90-2-2018/sostoyani
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http://dx.doi.org/10.26442/terarkh201890259-64DOI Listing
February 2018
4 Reads

Risk factors for upper and lower functional gastrointestinal disorders in Persian Gulf War Veterans during and post-deployment.

Neurogastroenterol Motil 2019 Jan 29:e13533. Epub 2019 Jan 29.

Department of Medicine, Tulane University School of Medicine, New Orleans, Louisiana.

Background: Gastroenteritis is a risk factor for irritable bowel syndrome (IBS), but its role in other functional gastrointestinal disorders (FGIDs) is less clear. The aim of this study was to determine the prevalence of FGIDs in Gulf War (GW) Veterans before, during, and after deployment and to determine whether gastroenteritis was a risk factor for upper and lower FGIDs.

Methods: The Veterans who served during the Persian GW were mailed validated questionnaires inquiring about their bowel habits, psychological and extra-intestinal symptoms, and quality of life (QOL). Read More

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http://doi.wiley.com/10.1111/nmo.13533
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http://dx.doi.org/10.1111/nmo.13533DOI Listing
January 2019
4 Reads

The effect of aerobic exercises among women with mild and moderate irritable bowel syndrome: A pilot study.

J Bodyw Mov Ther 2019 Jan 5;23(1):161-165. Epub 2018 Feb 5.

Department of Biostatistics and Epidemiology, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran.

Background: Irritable Bowel Syndrome (IBS) is a functional bowel disorder characterized by abdominal pain or discomfort. Although patients with IBS are commonly recommended to increase their physical activity, after reviewing the literature, it was found that no study has assessed the effect of aerobic exercises on the severity of symptoms and quality of life in patients with IBS. Therefore the aim of the present study was to evaluate the effect of aerobic exercises with treadmill on the severity of symptoms and quality of life among women with mild and moderate IBS. Read More

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http://dx.doi.org/10.1016/j.jbmt.2018.02.003DOI Listing
January 2019

Population based study: atopy and autoimmune diseases are associated with functional dyspepsia and irritable bowel syndrome, independent of psychological distress.

Aliment Pharmacol Ther 2019 Mar 27;49(5):546-555. Epub 2019 Jan 27.

Faculty of Health and Medicine, University of Newcastle, Callaghan, NSW, Australia.

Background: The pathogenesis of functional GI disorders (FGIDs) is uncertain. However, underlying immune activation and psychological distress has been documented in irritable bowel syndrome (IBS) and functional dyspepsia (FD). Epidemiological data from the UK suggest that FGIDs are linked to atopy and certain autoimmune diseases but this has not been confirmed. Read More

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http://dx.doi.org/10.1111/apt.15120DOI Listing
March 2019
3 Reads

Ginger in gastrointestinal disorders: A systematic review of clinical trials.

Food Sci Nutr 2019 Jan 5;7(1):96-108. Epub 2018 Nov 5.

Department of Clinical Nutrition and Dietetics Faculty of Nutrition Sciences and Food Technology National Nutrition and Food Technology Research Institute Shahid Beheshti University of Medical Sciences Tehran Iran.

Ginger, the rhizome of Zingiber officinale, which is used as a spice globally has a long history of medicinal use that stimulates investigators to assess its potential roles as an adjuvant therapy or alternative medicine in a range of diseases. Anti-inflammatory, antioxidant, antitumor, and antiulcer effects of ginger have been proven in many scientific studies, and some of the ancient applications of ginger as a home remedy has been confirmed in human. In this review, we summarized the current evidence on the effects of ginger consumption on gastrointestinal disorders based on clinical trials. Read More

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http://dx.doi.org/10.1002/fsn3.807DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341159PMC
January 2019
1 Read