14,421 results match your criteria Irritable Bowel Syndrome


Electroacupuncture Improves IBS Visceral Hypersensitivity by Inhibiting the Activation of Astrocytes in the Medial Thalamus and Anterior Cingulate Cortex.

Evid Based Complement Alternat Med 2020 12;2020:2562979. Epub 2020 Jun 12.

Key Laboratory of Acupuncture and Immunological Effects, Shanghai University of Traditional Chinese Medicine, Shanghai 200030, China.

Objective: To explore whether the effect of electroacupuncture (EA) on visceral hypersensitivity (VH) in rats with irritable bowel syndrome (IBS) is related to the changes of astrocyte activation in the medial thalamus (MT) and anterior cingulate cortex (ACC).

Method: Male Sprague-Dawley rats were randomly divided into the normal control (NC) group, model control (MC) group, electroacupuncture (EA) group, and fluorocitrate (FCA) group. A model of visceral hypersensitivity was established by neonatal colorectal irritation. Read More

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http://dx.doi.org/10.1155/2020/2562979DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306073PMC

TRPM8 channels: A review of distribution and clinical role.

Eur J Pharmacol 2020 Jun 28:173312. Epub 2020 Jun 28.

Department of Clinical Pharmacy, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Jiangsu Province, Nanjing, 211198, PR China; Department of Surgery, Zhongda Hospital Affiliated to Southeast University, Nanjing, Jiangsu Province, 210017, PR China; Department of Surgery, Nanjing Shuiximen Hospital, Jiangsu Province, 210017, PR China. Electronic address:

Ion channels are important therapeutic targets due to their plethoric involvement in physiological and pathological consequences. The transient receptor potential cation channel subfamily M member 8 (TRPM8) is a nonselective cation channel that controls Ca homeostasis. It has been proposed to be the predominant thermoreceptor for cellular and behavioral responses to cold stimuli in the TRP channel subfamilies and exploited so far to reach the clinical-stage of drug development. Read More

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http://dx.doi.org/10.1016/j.ejphar.2020.173312DOI Listing

The Epidemiology of Migraine Headache in Arab Countries: A Systematic Review.

ScientificWorldJournal 2020 16;2020:4790254. Epub 2020 Jun 16.

Ministry of Health, Riyadh, Saudi Arabia.

Background: Recurring migraine disorders are a common medical problem, standing among the top causes of disability and sufferings. This study aimed to evaluate epidemiological evidence to report updated estimates on prevalence, risk factors, and associated comorbidities of migraine headache in the Arab countries. . Read More

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http://dx.doi.org/10.1155/2020/4790254DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315321PMC

Association Between Irritable Bowel Syndrome and Sleep Disturbance in Adolescents.

Adolesc Health Med Ther 2020 11;11:73-77. Epub 2020 Jun 11.

Department of Pediatrics, Faculty of Medicine, Universitas Sriwijaya and Moh Hoesin Hospital, Palembang, Indonesia.

Introduction: Sleep disorder in adolescents is a problem that is rarely considered by both parents and healthcare professionals. Ignorance of sleep disorders is likely caused by the very rare occurrence of associated sporadic or emergency cases. Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder characterized by abdominal pain and changes in the defecation pattern. Read More

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http://dx.doi.org/10.2147/AHMT.S248711DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7295206PMC

Eudragit-S100 Coated PLGA Nanoparticles for Colon Targeting of Etoricoxib: Optimization and Pharmacokinetic Assessments in Healthy Human Volunteers.

Int J Nanomedicine 2020 8;15:3965-3980. Epub 2020 Jun 8.

Department of Pharmaceutics & Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Cairo, Egypt.

Aim: Etoricoxib is a selective inhibitor of COX-2 enzyme. It is proposed as a potent anti-inflammatory drug intended for the control of irritable bowel syndrome. The current work aimed at developing etoricoxib-loaded nanoparticles for colon- targeting. Read More

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http://dx.doi.org/10.2147/IJN.S244124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293536PMC

Fecal microbiota transplantation in gastrointestinal disorders: time for precision medicine.

Genome Med 2020 Jun 30;12(1):58. Epub 2020 Jun 30.

French Group of Fecal Microbiota Transplantation (GFTF; www.gftf.f), Paris, France.

Fecal microbiota transplantation (FMT) has demonstrated efficacy in treating inflammatory bowel diseases and irritable bowel syndrome in an increasing number of randomized controlled trials. Recently published data gives striking insights into the factors associated with FMT success paving the road for the use of precision medicine in gastrointestinal disorders. Read More

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http://dx.doi.org/10.1186/s13073-020-00757-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7329555PMC

The efficacy of Bifidobacterium quadruple viable tablet in the treatment of diarrhea predominant irritable bowel syndrome: protocol for a randomized, double-blind, placebo-controlled, multicenter trial.

Trials 2020 Jun 30;21(1):597. Epub 2020 Jun 30.

Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan, Hubei, China.

Background: Irritable bowel syndrome (IBS) is one of the most common functional gastrointestinal disorders characterized by recurrent abdominal pain associated with defecation or a change in bowel habits. Leading to significant negative effect on patients' quality of life and huge financial burden to health system, the management of IBS is a great challenge. Probiotics are considered as an effective therapy; however, in a lack of high-quality evidence of efficacy, no strain- and dose-specific probiotics were recommended in clinical guidelines. Read More

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http://dx.doi.org/10.1186/s13063-020-04490-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7329396PMC

[Methanobrevibacter smithii in irritable bowel syndrome: a clinical and molecular study].

Ter Arkh 2019 Aug 15;91(8):47-51. Epub 2019 Aug 15.

Yevdokimov Moscow State University of Medicine and Dentistry.

Aim: To assess the role of Methanobrevibacter smithii in patients with irritable bowel syndrome associated with small intestinal bowel overgrowth.

Materials And Methods: Sixty - seven patients with IBS according to Rome IV were enrolled into the study in whom hydrogen breath test was performed. Thirty - two healthy subjects with negative breath test was used as a control. Read More

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http://dx.doi.org/10.26442/00403660.2019.08.000383DOI Listing

[Functional diseases of the gastrointestinal tract in the context with overlapping functional disorders: current status of the problem].

Ter Arkh 2020 Apr 27;92(2):111-118. Epub 2020 Apr 27.

State Budgetary Healthcare Institution of Moscow «City Polyclinic №52», of the Moscow City Healthcare Department.

Functional diseases of the gastrointestinal tract cause significant damage to the health care system. Their frequent combination in the same patient with the migration of clinical symptoms throughout the digestive tube is accompanied by continuous exacerbations, refractory to the therapy and severe psychosocial disorders. This review provides data on the main etiopathogenetic factors, clinical manifestations, course features and management tactics for patients with overlapping for the most common functional diseases of the gastrointestinal tract. Read More

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http://dx.doi.org/10.26442/00403660.2020.02.000458DOI Listing

[Multidisciplinary treatment of the patient with a severe irritable bowel syndrome].

Ter Arkh 2020 Apr 27;92(2):81-84. Epub 2020 Apr 27.

Loginov Moscow Clinical Scientific Practical Center.

The patient E., aged 39, was described with a severe form of the irritable bowel syndrome that developed after the stress. In addition to the clinical manifestations of IBS, the patient got the somatoform disorders, which manifested itself with a large number of extraintestinal symptoms and led to a disability. Read More

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http://dx.doi.org/10.26442/00403660.2020.02.000523DOI Listing

[Chronic pancreatitis with IBS-like syndrome: approach to therapy].

Ter Arkh 2020 Apr 27;92(2):61-66. Epub 2020 Apr 27.

Sechenov First Moscow State Medical University (Sechenov University).

Aim: To determine approaches of the exacerbations treatment of chronic pancreatitis (CP) with IBS (irritable bowel syndrome)-like syndrome.

Materials And Methods: 312 patients with exacerbation of CP were observed and received standard therapy: antispasmodics, enzymes, proton pump inhibitors. 85 (27. Read More

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http://dx.doi.org/10.26442/00403660.2020.02.000518DOI Listing

[Esophageal disorders in patients with irritable bowel syndrome].

Ter Arkh 2020 Apr 27;92(2):19-23. Epub 2020 Apr 27.

Sechenov First Moscow State Medical University (Sechenov University).

Aim: To study the whole range of esophageal disorders in patients with irritable bowel syndrome (IBS) using high-tech methods.

Materials And Methods: 102 IBS patients (47 males, mean age 40.8, diagnosis of IBS was established according to Rome III criteria) with esophageal symptoms (heartburn, belching, globus sensation and noncardiac chest pain) were examined in gastroenterology department. Read More

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http://dx.doi.org/10.26442/00403660.2020.02.000483DOI Listing

Enzyme therapy: A forerunner in catalyzing a healthy society?

Expert Opin Biol Ther 2020 Jun 27. Epub 2020 Jun 27.

Department of Biomedical Sciences, College of Health and Sciences, QU Health, Qatar University , Doha, Qatar.

Introduction: The use of enzymes in various industries has been prevalent for centuries. However, their potency as therapeutics remained latent until the late 1950s, when scientists finally realised the gold mine they were sitting on. Enzyme therapy has seen rapid development over the past few decades and has been widely used for the therapy of myriad diseases, including lysosomal storage disorders, cancer, Alzheimer's disease, irritable bowel syndrome, exocrine pancreatic insufficiency, and hyperuricemia. Read More

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http://dx.doi.org/10.1080/14712598.2020.1787980DOI Listing

The Epidemiology of Celiac Disease in the General Population and High-Risk Groups in Arab Countries: A Systematic Review.

Biomed Res Int 2020 3;2020:6865917. Epub 2020 Jun 3.

King Abdulaziz Medical City, National Guard Health Affairs, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.

Background And Aims: Celiac disease (CD) is possibly the most common autoimmune disorder, which may lead to dietary problems in the Arab region. This paper is aimed at exploring the epidemiology of the celiac disease in Arab countries, including its prevalence, associated risk factors, and clinical patterns.

Methods: An extensive search of the literature was conducted from electronic databases such as PubMed, Embase, and Google Scholar. Read More

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http://dx.doi.org/10.1155/2020/6865917DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7292982PMC

Significance of G Protein-Coupled Estrogen Receptor in the Pathophysiology of Irritable Bowel Syndrome, Inflammatory Bowel Diseases and Colorectal Cancer.

Front Endocrinol (Lausanne) 2020 12;11:390. Epub 2020 Jun 12.

Department of Cytobiochemistry, Faculty of Biology and Environmental Protection, University of Lodz, Lodz, Poland.

The regulatory role of estrogens and nuclear estrogen receptors, i. e., estrogen receptor α and β has been reported in gastrointestinal diseases. Read More

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http://dx.doi.org/10.3389/fendo.2020.00390DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303275PMC

[Association between the clinical efficacy of fecal microbiota transplantation in recipients and the choice of donor].

Zhonghua Wei Chang Wai Ke Za Zhi 2020 Jul;23(Z1):69-76

Department of Colorectal Disease Specialty, Intestinal Microecology Diagnosis and Treatment Center, the Tenth People's Hospital, Tongji University, Shanghai 200072, China.

To examine the association between the clinical efficacy of fecal microbiota transplantation (FMT) in recipients and the choice of donor, and to observe the characteristics of intestinal flora and metabolites among different donors. A retrospective case-control study was conducted. Donor whose feces was administrated for more than 30 recipients was enrolled. Read More

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http://dx.doi.org/10.3760/cma.j.cn.441530-20200417-00222DOI Listing

[Effect of intestinal preparation on the efficacy and safety of fecal microbiota transplantation treatment].

Zhonghua Wei Chang Wai Ke Za Zhi 2020 Jul;23(Z1):48-55

Department of Colorectal Disease Specialty, Intestinal Microecology Diagnosis and Treatment Center, theTenth People's Hospital, Tongji University, Shanghai 200072, China.

To investigate the effect of intestinal preparation on the efficacy and complications of fecal microbiota transplantation (FMT). A retrospective cohort study was performed. Clinical and follow-up data of 1501 patients who received FMT in the department of Colorectal Disease Specialty, Intestinal Microecology Diagnosis and Treatment Center, the Tenth People's Hospital, Tongji University from February 2018 to June 2019 were collected retrospectively. Read More

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http://dx.doi.org/10.3760/cma.j.cn.441530-20200418-00225DOI Listing

Neuropsychological function is related to irritable bowel syndrome in women with premenstrual syndrome and dysmenorrhea.

Arch Gynecol Obstet 2020 Jun 27. Epub 2020 Jun 27.

Cellular and Molecular Research Center, Birjand University of Medical Sciences, Birjand, Iran.

Background: There is increasing evidence demonstrating the co-occurrence of primary dysmenorrhea (PD), premenstrual syndrome (PMS), and irritable bowel syndrome (IBS) in women. This study aimed to investigate whether women who have symptoms of IBS in addition to PD and PMS also report more severe or frequent menstruation-associated symptoms and psychological complications compared to women with PD and PMS alone.

Methods: The study group included 182 female University students aged 18-25 years. Read More

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http://dx.doi.org/10.1007/s00404-020-05659-3DOI Listing

Oral Administration of S-Adenosylmethionine (SAMe) and Lactobacillus Plantarum HEAL9 Improves the Mild-To-Moderate Symptoms of Depression: A Randomized, Double-Blind, Placebo-Controlled Study.

Prim Care Companion CNS Disord 2020 Jun 25;22(4). Epub 2020 Jun 25.

Nutrilinea SRL, Varese, Italy.

Objective: To assess the effects of the combination of SAMe (S-adenosylmethionine) 200 mg and Lactobacillus plantarum (L. plantarum) HEAL9 1 × 10⁹ CFU for the overall symptomatology of mild-to-moderate depression.

Methods: This 6-week randomized, double-blind, placebo-controlled study included subjects aged 18-60 years with mild-to-moderate depression (according to ICD-10 diagnostic criteria) recruited from September 17, 2018, to October 5, 2018. Read More

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http://dx.doi.org/10.4088/PCC.19m02578DOI Listing

Audit of the impact of the York faecal calprotectin care pathway on colonoscopy activity.

Frontline Gastroenterol 2020 24;11(4):285-289. Epub 2019 Oct 24.

Biochemistry, York Teaching Hospital NHS Foundation Trust, York, UK.

Background: The York faecal calprotectin care pathway (YFCCP) was developed to optimise effective primary care differentiation between irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD). We undertook an audit of colonoscopy activity at York Teaching Hospitals after the introduction of the YFCCP, to assess its impact.

Methods: Faecal calprotectin (FC) results were reconciled with colonoscopy activity in patients 18-60 years after the implementation of the YFCCP. Read More

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http://dx.doi.org/10.1136/flgastro-2019-101315DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7307046PMC
October 2019

alleviates irritable bowel syndrome-related visceral hypersensitivity and microbiota dysbiosis via Paneth cell regulation.

Gut Microbes 2020 Jun 25:1-17. Epub 2020 Jun 25.

Department of Gastroenterology, Ruijin Hospital Affiliated to Shanghai Jiao Tong University , Shanghai, China.

Although the oral administration of () relieves the signs of irritable bowel syndrome (IBS) in clinical settings, the mechanisms underlying its effects are unclear. In this study, we evaluated the precise effects of on IBS via regulation of Paneth cell function. We confirmed the beneficial effects of on defecation habits and visceral hypersensitivity in WAS rats. Read More

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http://dx.doi.org/10.1080/19490976.2020.1782156DOI Listing

Randomised clinical trial: minesapride vs placebo for irritable bowel syndrome with predominant constipation.

Aliment Pharmacol Ther 2020 Jun 25. Epub 2020 Jun 25.

Division of Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan.

Background: Agonists of 5-hydroxytryptamine 4 receptor are potential agents for irritable bowel syndrome with predominant constipation (IBS-C). However, only tegaserod has been approved for a very limited population in the US.

Aim: To evaluate the efficacy and safety of minesapride in patients with Rome IV defined IBS-C. Read More

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http://dx.doi.org/10.1111/apt.15907DOI Listing

Achillea spp.: A comprehensive review on its ethnobotany, phytochemistry, phytopharmacology and industrial applications.

Cell Mol Biol (Noisy-le-grand) 2020 Jun 25;66(4):78-103. Epub 2020 Jun 25.

Department of Physiology and Biophysics, Weill Cornell Medicine-Qatar, Education City, Qatar Foundation, Doha, P.O. Box 24144, Qatar.

The genus Achillea genus houses more than 100 species, a number of them are popularly used in traditional medicine for spasmodic gastrointestinal, gynecological and hepatobiliary disorders, hemorrhages, pneumonia, rheumatic pain, inflammation, wounds healing etc. Members of the genus contain a wide variety of volatile and non-volatile secondary metabolites, including terpenes, polyphenols, flavonoids and others. Multiple studies have assessed the biological effects and other aspects of Achillea spp. Read More

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June 2020
1.234 Impact Factor

Tryptophan Metabolites Along the Microbiota-Gut-Brain Axis: An Interkingdom Communication System Influencing the Gut in Health and Disease.

Int J Tryptophan Res 2020 11;13:1178646920928984. Epub 2020 Jun 11.

Department of Medicine and Surgery, University of Insubria, Varese, Italy.

The 'microbiota-gut-brain axis' plays a fundamental role in maintaining host homeostasis, and different immune, hormonal, and neuronal signals participate to this interkingdom communication system between eukaryota and prokaryota. The essential aminoacid tryptophan, as a precursor of several molecules acting at the interface between the host and the microbiota, is fundamental in the modulation of this bidirectional communication axis. In the gut, tryptophan undergoes 3 major metabolic pathways, the 5-HT, kynurenine, and AhR ligand pathways, which may be directly or indirectly controlled by the saprophytic flora. Read More

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http://dx.doi.org/10.1177/1178646920928984DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290275PMC

[Unique characteristics of "the second brain" - The enteric nervous system].

Sheng Li Xue Bao 2020 Jun;72(3):382-390

Department of Gastroenterology, Jingmen First Hospital, Jingmen 448000, China.

Enteric nervous system (ENS) is composed of intestinal submucosal and myenteric plexuses. ENS may independently regulate intestinal digestive and absorptive function, and it is also known as "the second brain" or gut brain. ENS has significant specificity relative to central nervous system (CNS) in properties and functional activities of neurons and neural circuits. Read More

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Effects of Lubiprostone, an Intestinal Secretagogue, on Electrolyte Homeostasis in Chronic Idiopathic and Opioid-induced Constipation.

J Clin Gastroenterol 2020 Jun 19. Epub 2020 Jun 19.

Mallinckrodt Pharmaceuticals, Rockville, MD.

Goals: To assess short-term and long-term effects of lubiprostone, a type-2 chloride channel activator, on electrolyte homeostasis.

Background: Conventional laxatives are associated with electrolyte imbalances. Lubiprostone is a type-2 chloride channel activator approved for treating chronic idiopathic constipation (CIC), opioid-induced constipation (OIC), and constipation-predominant irritable bowel syndrome in women. Read More

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http://dx.doi.org/10.1097/MCG.0000000000001385DOI Listing

Preliminary Study on the Tears Oxidative Stress Status and Sleep Disturbances in Irritable Bowel Syndrome Patients.

Oxid Med Cell Longev 2020 23;2020:4690713. Epub 2020 May 23.

Department of Biology, Faculty of Biology, Alexandru Ioan Cuza University of Iași, Carol I Avenue, 20A, Iași, Romania.

According to the latest gastrointestinal disorders diagnostic criteria (ROME IV), the irritable bowel syndrome (IBS) is mainly characterized by the presence of abdominal pain and changes in intestinal transit. However, both sleep impairments and oxidative status changes (in patients' sera, mucosal level, and other body fluids) were reported IBS. Thus, in this study, we aimed to evaluate several aspects regarding the oxidative stress status in patients' tears as well as sleep disturbances by comparison with the intensity of IBS symptoms, as assessed by the visual analogue scale for irritable bowel syndrome (VAS-IBS). Read More

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http://dx.doi.org/10.1155/2020/4690713DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7271000PMC

Abdominal Massage Reduces Visceral Hypersensitivity via Regulating GDNF and PI3K/AKT Signal Pathway in a Rat Model of Irritable Bowel Syndrome.

Evid Based Complement Alternat Med 2020 5;2020:3912931. Epub 2020 Jun 5.

Institute of Biomedical Engineering, Chinese Academy of Medical Science & Peking Union Medical College, Tianjin 300192, China.

Changes in gut motility and visceral hypersensitivity are two major features of irritable bowel syndrome (IBS). Current drug treatments are often poorly efficacious, with many side effects for patients with IBS. Complementary therapies, such as acupuncture or abdominal massage, have received more attention in recent years. Read More

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http://dx.doi.org/10.1155/2020/3912931DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293735PMC

Efficacy and Safety of a Novel Herbal Medicine in the Treatment of Irritable Bowel Syndrome: A Randomized Double-Blinded Clinical Trial.

Gastroenterol Res Pract 2020 27;2020:8213082. Epub 2020 May 27.

Pharmaceutical Sciences Research Center, Department of Medicinal Chemistry, Mazandaran University of Medical Sciences, Sari, Iran.

Background: The unresponsiveness to conventional pharmacological treatments and their side effects have led patients with irritable bowel syndrome (IBS) to use complementary and alternative medicine such as herbal remedies. Beside, Boiss (ZM), L. (TA), and L. Read More

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http://dx.doi.org/10.1155/2020/8213082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7273440PMC

Vulvar pain: The revealing scenario of leading comorbidities in 1183 cases.

Eur J Obstet Gynecol Reprod Biol 2020 May 30;252:50-55. Epub 2020 May 30.

ASP 7, Ragusa Hospital, Italy.

Objectives: This study set out to investigate the epidemiological characteristics and comorbidities of chronic vulvar pain. Secondary goals were to identify the preferred approaches for managing vulvodynia in Italy.

Study Design: A cross-sectional study (the VuNet -Vulvodynia Network project) was performed in consecutive female patients with chronic vulvar pain attending 21 Italian medical centers (public hospitals, university clinics and private outpatient services) in the period December 2016 to November 2018. Read More

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http://dx.doi.org/10.1016/j.ejogrb.2020.05.052DOI Listing

Review article: FODMAPS, prebiotics and gut health-the FODMAP hypothesis revisited.

Aliment Pharmacol Ther 2020 Jul 20;52(2):233-246. Epub 2020 Jun 20.

Department of Gastroenterology, Monash University and Alfred Health, Melbourne, Vic., Australia.

Background: Restriction of dietary FODMAP intake can alleviate symptoms in patients with irritable bowel syndrome. Because many FODMAPs have prebiotic actions, there is concern that their dietary restriction leads to dysbiosis with health consequences, and their intake is being encouraged by addition to foods and via supplements.

Aims: To examine the hazards and benefits of high and low FODMAP intake. Read More

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http://dx.doi.org/10.1111/apt.15818DOI Listing

Irritable bowel syndrome increases the risk of chronic obstructive pulmonary disease: A retrospective cohort study.

Sci Rep 2020 Jun 19;10(1):10008. Epub 2020 Jun 19.

Department of Chinese Medicine, China Medical University Hospital, Taichung, Taiwan.

Both inflammation and infection are associated with the development of irritable bowel syndrome (IBS) and chronic obstructive pulmonary disease (COPD). The purpose of this study is to further elucidate the association between IBS and COPD through a retrospective cohort study. We enrolled IBS patients diagnosed between 2000 and 2011 with follow-up for at least one year. Read More

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http://dx.doi.org/10.1038/s41598-020-66707-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7305148PMC

Pomegranate Mesocarp against Colitis-Induced Visceral Pain in Rats: Effects of a Decoction and Its Fractions.

Int J Mol Sci 2020 Jun 17;21(12). Epub 2020 Jun 17.

Department of Neuroscience, Psychology, Drug Research and Child Health-NEUROFARBA-Pharmacology and Toxicology Section, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy.

The management of chronic visceral pain related to Inflammatory Bowel Diseases or Irritable Bowel Syndrome is still a clinical problem and new therapeutic strategies continue to be investigated. In the present study, the efficacy of a pomegranate decoction and of its polysaccharide and ellagitannin components in preventing the development of colitis-induced abdominal pain in rats was evaluated. After colitis induction by 2,4-dinitrobenzenesulfonic acid (DNBS), the pomegranate decoction (300 mg kg), polysaccharides (300 mg kg), and ellagitannins (45 mg kg) were orally administered for 14 days. Read More

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http://dx.doi.org/10.3390/ijms21124304DOI Listing

The Role of Bile Acids in Chronic Diarrhea.

Am J Gastroenterol 2020 Jun 11. Epub 2020 Jun 11.

Division of Gastroenterology and Hepatology, Department of Medicine, Clinical Enteric Neuroscience Translational and Epidemiological Research (C.E.N.T.E.R.), Mayo Clinic, Rochester, Minnesota, USA.

Bile acids (BAs) are the central signals in enterohepatic communication, and they also integrate microbiota-derived signals into enterohepatic signaling. The tissue distribution and signaling pathways activated by BAs through natural receptors, farsenoid X receptor and G protein-coupled BA receptor 1 (GPBAR1, also known as Takeda G-coupled receptor 5), have led to a greater understanding of the mechanisms and potential therapeutic agents. BA diarrhea is most commonly encountered in ileal resection or disease, in idiopathic disorders (with presentation similar to functional diarrhea or irritable bowel syndrome with diarrhea), and in association with malabsorption such as chronic pancreatitis or celiac disease. Read More

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http://dx.doi.org/10.14309/ajg.0000000000000696DOI Listing

Importance of trauma-related fear in patients with irritable bowel syndrome and early adverse life events.

Neurogastroenterol Motil 2020 Jun 17:e13896. Epub 2020 Jun 17.

G Oppenheimer Center for Neurobiology of Stress and Resilience, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.

Background: Although early adverse life events (EALs) are prevalent among patients with irritable bowel syndrome (IBS), the impact of fear or dissociation experienced during the trauma has not been evaluated. We investigated the prevalence of fear at the time of trauma and its association with IBS status among individuals with early-life trauma before the age of 18.

Methods: Among participants with ≥1 EAL, association of fear and dissociation with IBS status was determined with logistic regression, and improvement in prediction of IBS over ETI score alone was determined with the likelihood ratio test. Read More

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http://dx.doi.org/10.1111/nmo.13896DOI Listing

Quality of life and psychometric evaluation of patients diagnosed with irritable bowel syndrome: an observational cohort study.

Sao Paulo Med J 2020 Jun 15. Epub 2020 Jun 15.

MD, PhD. Associate Professor, Department of General Surgery, Yenimahalle Training and Research Hospital, Yildirim Beyazıt University, Ankara, Turkey.

Background: Very few data are available for evaluating health-related quality of life among people with irritable bowel syndrome (IBS) and even fewer data are available in relation to anxiety and depression status among these patients.

Objectives: To evaluate the quality of life, anxiety and depression status of patients with IBS.

Design And Setting: Observational cohort study conducted in a tertiary-care university hospital. Read More

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http://dx.doi.org/10.1590/1516-3180.2019.0527.R1.16042020DOI Listing

Comorbidities of Patients with Functional Somatic Syndromes Before, During and After First Diagnosis: A Population-based Study using Bavarian Routine Data.

Sci Rep 2020 Jun 17;10(1):9810. Epub 2020 Jun 17.

Department of Internal Medicine VI: Psychosomatic Medicine and Psychotherapy, University Hospital Tübingen, Tübingen, Germany.

Functional somatic syndromes (FSS) are characterised by the presence of one or multiple chronic symptoms that cannot be attributed to a known somatic disease. They are thought to arise though a complex interaction of biological and psychosocial factors, but it is unclear whether they share a common aetiology. One hypothesis supported by recent studies is that the FSS are postinfectious disorders, as is widely recognised for a subset of patients with irritable bowel syndrome. Read More

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http://dx.doi.org/10.1038/s41598-020-66685-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7299983PMC

Associations among neurophysiology measures in irritable bowel syndrome (IBS) and their relevance for IBS symptoms.

Sci Rep 2020 Jun 17;10(1):9794. Epub 2020 Jun 17.

Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Abnormal gut-brain interactions are common in irritable bowel syndrome (IBS), but the associations between neurophysiological measures and their relation to gastrointestinal (GI) symptoms are poorly understood. Our aim was to explore these relationships and define the most relevant neurophysiology measures for GI symptom severity in IBS. IBS patients underwent small intestinal motility (manometry; fasted and fed contraction frequency, phase III time) and secretion (transmural potential difference), rectal sensorimotor (barostat; sensory thresholds, tone response, compliance), autonomic nervous system (baroreceptor sensitivity and effectiveness), and colonic motor function (transit time) examinations. Read More

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http://dx.doi.org/10.1038/s41598-020-66558-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7300023PMC

Associations of Abdominal Pain and Psychosocial Distress Measures With Health-Related Quality-of-Life in Pediatric Healthy Controls and Irritable Bowel Syndrome.

J Clin Gastroenterol 2020 Jun 16. Epub 2020 Jun 16.

Department of Pediatrics, Section of Gastroenterology, Hepatology, and Nutrition.

Background: Children with irritable bowel syndrome (IBS) have lower health-related quality-of-life (HRQOL) than healthy controls (HC). Abdominal pain and psychosocial distress are negatively associated with HRQOL, although their relative effect is unclear.

Aim: The aim of this study was to compare the relative associations of abdominal pain and psychosocial distress with HRQOL in HC and IBS. Read More

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http://dx.doi.org/10.1097/MCG.0000000000001373DOI Listing

Microbial and metabolomic profiles in correlation with depression and anxiety co-morbidities in diarrhoea-predominant IBS patients.

BMC Microbiol 2020 Jun 17;20(1):168. Epub 2020 Jun 17.

Department of Gastroenterology, Qilu Hospital, Cheloo College of Medicine, Shandong University, 107 Wenhuaxi Road, Jinan, 250012, Shandong Province, China.

Background: Psychological co-morbidities in irritable bowel syndrome (IBS) have been widely recognized, whereas less is known regarding the role of gut microbial and host metabolic changes in clinical and psychological symptoms in IBS.

Results: A total of 70 diarrhoea-predominant IBS (IBS-D) patients and 46 healthy controls were enrolled in this study. Stool and urine samples were collected from both groups for 16S rRNA gene sequencing and metabolomic analysis. Read More

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http://dx.doi.org/10.1186/s12866-020-01841-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7302156PMC

Determination of butyric acid dosage based on clinical and experimental studies - a literature review.

Prz Gastroenterol 2020 8;15(2):119-125. Epub 2020 Jun 8.

Clinic of Internal Diseases and Gastroenterology, Central Teaching Hospital of the Ministry of Interior and Administration (MSWiA), Warsaw, Poland.

Short-chain fatty acids produced by bacteria living in the large intestine are the main energy substrate for the colonocytes. Butyric acid is used for the treatment and prevention of exacerbations of various gastrointestinal diseases: diarrhoea, intestinal inflammations, functional disorders, dysbiosis, and post-surgery or post-chemotherapy conditions. The current standard doses of butyric acid (150-300 mg) range between 1. Read More

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http://dx.doi.org/10.5114/pg.2020.95556DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294979PMC

Are probiotics useful in the treatment of chronic idiopathic constipation in adults? A review of existing systematic reviews, meta-analyses, and recommendations.

Prz Gastroenterol 2020 17;15(2):103-118. Epub 2019 Jul 17.

Department of Gastroenterology, Pomeranian Medical University, Szczecin, Poland.

Chronic idiopathic constipation (CIC) has emerged as common problem for contemporary gastroenterology and is one of the most frequent complaints in primary care. Chronic idiopathic constipation significantly affects patients' quality of life and has an impact on global health and economy. Functional gastrointestinal disorders and bowel disorders, according to Rome IV criteria, result from inappropriate gut-brain interactions. Read More

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http://dx.doi.org/10.5114/pg.2019.86747DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294971PMC

Focal Active Colitis Presented With Chronic Diarrhea.

Cureus 2020 May 15;12(5):e8140. Epub 2020 May 15.

Gastroenterology, AdventHealth, Orlando, USA.

There are various etiologies of colonic injury and inflammation. The most commonly described colitides in clinical practice are associated with infection, inflammatory bowel disease, ischemia, radiation and medications. The colonic wall has a limited set of responses to different types of injury; therefore, there is overlap between many of these disorders. Read More

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http://dx.doi.org/10.7759/cureus.8140DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294873PMC

Gastrointestinal symptoms in acromegaly: A case control study.

World J Gastrointest Pharmacol Ther 2020 Jun;11(2):17-24

Department of Gastroenterology, St Georges Hospital and St Georges, University of London, London SW17 0QT, United Kingdom.

Background: Acromegaly is a chronic disease caused by a pituitary somatotroph adenoma resulting in excess secretion of growth hormone, which leads to excess secretion of Insulin like growth factor 1 from the liver, causing abnormal soft tissue growth. There is increasing awareness that diseases affecting connective tissue are associated with an increase in functional gastrointestinal symptoms. Data was collected from patients with a confirmed diagnosis of acromegaly to evaluate the intensity, variety and impact of abdominal symptoms in comparison with a control group who were healthy participants recruited from the local fracture clinic. Read More

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http://dx.doi.org/10.4292/wjgpt.v11.i2.17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7288728PMC

Predictors of new onsets of irritable bowel syndrome, chronic fatigue syndrome and fibromyalgia: the lifelines study.

Psychol Med 2020 Jun 17:1-9. Epub 2020 Jun 17.

Neuroscience and Mental Health, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.

Background: It has been claimed that functional somatic syndromes share a common etiology. This prospective population-based study assessed whether the same variables predict new onsets of irritable bowel syndrome (IBS), chronic fatigue syndrome (CFS) and fibromyalgia (FM).

Methods: The study included 152 180 adults in the Dutch Lifelines study who reported the presence/absence of relevant syndromes at baseline and follow-up. Read More

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http://dx.doi.org/10.1017/S0033291720001774DOI Listing

The Impact of an Individual Educational Program on the Quality of Life and Severity of Symptoms of Patients with Irritable Bowel Syndrome.

Int J Environ Res Public Health 2020 Jun 13;17(12). Epub 2020 Jun 13.

Department of Gastroenterology and Internal Medicine, Medical University of Bialystok, 15-089 Bialystok, Poland.

Background: Irritable bowel syndrome (IBS) is one of the most common functional diseases of the gastrointestinal tract. A typical symptom is changed bowel patterns: diarrhea, constipation, or alternation of the two. Abdominal pains vary in intensity and location, with periods of exacerbation and remission, causing disorganization in everyday life and work. Read More

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http://dx.doi.org/10.3390/ijerph17124230DOI Listing

An invited commentary on "The efficacy and safety of probiotics for patients with constipation-predominant irritable bowel syndrome: A systematic review and meta-analysis based on seventeen randomized controlled trials" [Int. J. Surg. 79 (2020) 111-119].

Authors:
Andy Petroianu

Int J Surg 2020 Jun 13;80:3-4. Epub 2020 Jun 13.

Department of Surgery, School of Medicine, Federal University of Minas Gerais, Avenida Afonso Pena 1626 - Apto. 1901, Belo Horizonte, 30130-005, Brazil. Electronic address:

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http://dx.doi.org/10.1016/j.ijsu.2020.06.006DOI Listing

Non-bladder centric interstitial cystitis/bladder pain syndrome phenotype is significantly associated with co-occurring endometriosis.

Can J Urol 2020 Jun;27(3):10257-10262

Department of Urology/Pelvic Health, Wake Forest Baptist Health, Winston-Salem, North Carolina, USA.

Introduction: Interstitial cystitis/bladder pain syndrome (IC/BPS) and endometriosis are coexistent diagnoses in 48%-65% of women with chronic pelvic pain (CPP), suggesting that dual screening may be warranted. To further investigate the clinical relationship and risk factors between these two conditions, we performed a retrospective review of our large IC/BPS patient data registry.

Materials And Methods: We evaluated IC/BPS patients who were prospectively enrolled into our registry who completed validated questionnaires and underwent therapeutic hydrodistension, during which anesthetic bladder capacity (BC) and Hunner's lesion (HL) status were recorded. Read More

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Irritable Bowel Syndrome in a Population of a Developing Country: Prevalence and Association.

Cureus 2020 May 14;12(5):e8112. Epub 2020 May 14.

Gastroenterology, Liaquat National Hospital and Medical College, Karachi, PAK.

Introduction:  Irritable bowel syndrome (IBS) is included as one of the functional gastrointestinal (GI) related disorders presenting with pain in abdomen of chronic duration in the absence of any identifiable organic cause. Bloating, distension of abdomen, and defecation in disordered manner are other features commonly associated with IBS. It is a complex disorder with mixed physiological, psychological, and social interactions. Read More

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http://dx.doi.org/10.7759/cureus.8112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7292712PMC

Clinical effects of Lactobacillus strains as probiotics in the treatment of irritable bowel syndrome. Results from the LAPIBSS trial: Future objectives.

Cell Mol Biol (Noisy-le-grand) 2020 Jun 5;66(3):211-214. Epub 2020 Jun 5.

Laboratoire Denel-Codifra, Le Chesnay, France.

The objective of this communication is to present and analyze the recent results from the LAPIBSS study in order to improve future clinical trials on the effects of Lactobacillus strains in the treatment of irritable bowel syndrome (IBS). Using a tightly-controlled clinical trial protocol with the highest Jadad score of 5/5, the current trial aimed to demonstrate the efficacy of a 2-strain mixture of Lactobacillus acidophilus (L. acidophilus) to improve IBS symptoms. Read More

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