13,313 results match your criteria Irritable Bowel Syndrome


Early life stress disrupts intestinal homeostasis via NGF-TrkA signaling.

Nat Commun 2019 Apr 15;10(1):1745. Epub 2019 Apr 15.

Institute of Brain and Gut Axis (IBAG), Centre of Clinical Research for Chinese Medicine, School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong SAR, China.

Early childhood is a critical period for development, and early life stress may increase the risk of gastrointestinal diseases including irritable bowel syndrome (IBS). In rodents, neonatal maternal separation (NMS) induces bowel dysfunctions that resemble IBS. However, the underlying mechanisms remain unclear. Read More

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http://dx.doi.org/10.1038/s41467-019-09744-3DOI Listing

The central role of psychopathology and its association with disease severity in inflammatory bowel disease and irritable bowel syndrome.

Riv Psichiatr 2019 Mar-Apr;54(2):75-83

Department of Internal Medicine and Medical Specialties, Policlinico Umberto I, Sapienza University of Rome, Italy - Department of Gastroenterology, Humanitas Clinical Institute, Rozzano (Milan), Italy.

Background: Biopsychosocial models for both organic and functional gastrointestinal (GI) disorders can be found in the literature. To clarify the role of psychopathological factors and their relationship with GI symptom severity, several studies have examined them in inflammatory bowel disease (IBD) - occasionally distinguishing between ulcerative colitis (UC) and Crohn's disease (CD) - and in irritable bowel syndrome (IBS), leading to unclear results.

Aims: We aimed to evaluate the psychopathological features of IBD and IBS patients in comparison with healthy individuals and assess the association with disease severity. Read More

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http://dx.doi.org/10.1708/3142.31248DOI Listing

Acupuncture-Analgesia-Mediated Alleviation of Central Sensitization.

Evid Based Complement Alternat Med 2019 7;2019:6173412. Epub 2019 Mar 7.

Department of Chinese Medicine, China Medical University Hospital, Taichung 40447, Taiwan.

Pain can trigger central amplification called central sensitization, which ultimately results in hyperalgesia and/or allodynia. Many reports have showed acupuncture has an analgesic effect. We searched the related article on PubMed database and Cochrane database to discover central sensitization pathway in acupuncture analgesia. Read More

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http://dx.doi.org/10.1155/2019/6173412DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431485PMC

Electroacupuncture Alleviated Referral Hindpaw Hyperalgesia via Suppressing Spinal Long-Term Potentiation (LTP) in TNBS-Induced Colitis Rats.

Neural Plast 2019 11;2019:2098083. Epub 2019 Mar 11.

Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China.

Although referred pain or hypersensitivity has been repeatedly reported in irritable bowel syndrome (IBS) patients and experimental colitis rodents, little is known about the neural mechanisms. Spinal long-term potentiation (LTP) of nociceptive synaptic transmission plays a critical role in the development of somatic hyperalgesia in chronic pain conditions. Herein, we sought to determine whether spinal LTP contributes to the referral hyperalgesia in colitis rats and particularly whether electroacupuncture (EA) is effective to alleviate somatic hyperalgesia via suppressing spinal LTP. Read More

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http://dx.doi.org/10.1155/2019/2098083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432704PMC

[Syndrome de l'intestin irritable : de la comorbidité anxiodépressive au microbiote].

Authors:
Guillaume Fond

Rev Prat 2019 Feb;69(2):219-220

Université Aix- Marseille, faculté de médecine, secteur La Timone, EA 3279 : CEReSS (Centre d'étude et de recherche sur les services de santé et la qualité de vie), Marseille, France.

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February 2019
1 Read

Influence of Age and Body Mass Index on Total and Segmental Colonic Transit Times in Constipated Subjects.

J Neurogastroenterol Motil 2019 Apr;25(2):258-266

Service de'gastroentérologie, Hôpital Avicenne, Bobigny, France.

Background/aims: Discordant data are found in the literature for the relationships between total and segmental colonic transit time (CTT) and demographic parameters. The aim of this study is to examine the influence of age, and body mass index (BMI) on total and segmental CTT in constipated subjects.

Methods: We included 354 constipated patients on this cross-sectional study. Read More

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http://dx.doi.org/10.5056/jnm18167DOI Listing

Is Long-term Ambient Air Pollutant Exposure a Risk Factor for Irritable Bowel Syndrome in Children? A 12-year Longitudinal Cohort Study.

J Neurogastroenterol Motil 2019 Apr;25(2):241-249

Division of Pediatric Allergy, Immunology, and Rheumatology, Department of Pediatrics, Children's Hospital, China Medical University Hospital, Taichung, Taiwan.

Background/aims: Recent studies suggest that air pollution may play a role in gastrointestinal disorders. However, the effect of long-term exposure to air pollution on childhood irritable bowel syndrome (IBS) is unclear. Hence, we conducted a nationwide cohort study to investigate the association between long-term air pollution exposure and the incidence and risk of IBS in Taiwanese children during 2000-2012. Read More

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http://dx.doi.org/10.5056/jnm18135DOI Listing

Can Certain Foods Cause Gastrointestinal Symptoms in Korean Patients With Irritable Bowel Syndrome?

J Neurogastroenterol Motil 2019 Apr;25(2):179-180

Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Chungcheongnam-do, Korea.

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http://dx.doi.org/10.5056/jnm19052DOI Listing

Illuminating an Invisible Epidemic: A Systemic Review of the Clinical and Economic Benefits of Early Diagnosis and Treatment in Inflammatory Disease and Related Syndromes.

J Clin Med 2019 Apr 11;8(4). Epub 2019 Apr 11.

Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.

Healthcare expenditures in the United States are growing at an alarming level with the Centers for Medicare and Medicaid Services (CMS) projecting that they will reach $5.7 trillion per year by 2026. Inflammatory diseases and related syndromes are growing in prevalence among Western societies. Read More

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http://dx.doi.org/10.3390/jcm8040493DOI Listing
April 2019
1 Read

[Slow Transit Constipation].

Authors:
Marco Sailer

Zentralbl Chir 2019 Apr 12;144(2):179-189. Epub 2019 Apr 12.

Chirurgie, Bethesda KH Bergedorf, Hamburg, Deutschland.

Slow transit constipation is a rare condition that is almost exclusively encountered in middle-aged women. The pathophysiology and aetiology are poorly understood, but a multi-factorial pathogenesis seems likely. In the course of the differential diagnosis, mechanical, drug-induced, degenerative, metabolic, endocrinological, neurological and psychiatric causes of constipation must be excluded by an interdisciplinary approach. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/a-0860-5960
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http://dx.doi.org/10.1055/a-0860-5960DOI Listing
April 2019
3 Reads

Dietary Supplement Use in Gastrointestinal Symptom Management and Effect on Hopelessness Levels in Patients With Irritable Bowel Syndrome.

Holist Nurs Pract 2019 May/Jun;33(3):155-162

Ahmet Erdoğan Vocatıonal School of Health Services, Bulent Ecevit University, Zonguldak, Turkey (Dr Erdogan); and Faculty of Medicine, Public Health Department, Bulent Ecevit University, Zonguldak, Turkey (Dr Kurçer).

This study was conducted to determine the dietary supplement (DS) use in gastrointestinal symptom management, and its effect on hopelessness levels in patients with irritable bowel syndrome (IBS). The universe of this cross-sectional study consisted of 132 patients presenting at the polyclinic, while the sample consisted of 127 patients who meet the inclusion criteria to study. Data were collected using a patient identification form including sociodemographic characteristics and DS use, the Gastrointestinal Symptom Rating Scale, and the Beck Hopelessness Scale. Read More

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http://dx.doi.org/10.1097/HNP.0000000000000324DOI Listing
April 2019
1 Read

Assessing telephone-delivered cognitive-behavioural therapy (CBT) and web-delivered CBT versus treatment as usual in irritable bowel syndrome (ACTIB): a multicentre randomised trial.

Gut 2019 Apr 10. Epub 2019 Apr 10.

Department of Psychology, Institue of Psychiatry, Psychology and Neuroscience, King's College, London, UK.

Objective: To evaluate the clinical effectiveness of two modes of cognitive-behavioural therapy (CBT) for IBS compared with treatment as usual (TAU) in refractory IBS.

Design: A three-arm randomised controlled trial assessing telephone-delivered CBT (TCBT), web-based CBT (WCBT) with minimal therapist support, and TAU. Blinding participants and therapists was not possible. Read More

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http://dx.doi.org/10.1136/gutjnl-2018-317805DOI Listing
April 2019
1 Read

Increased Functional Foods' Consumption and Mediterranean Diet Adherence May Have a Protective Effect in the Appearance of Gastrointestinal Diseases: A Case⁻Control Study.

Medicines (Basel) 2019 Apr 9;6(2). Epub 2019 Apr 9.

Department of Food Science and Nutrition, University of the Aegean, Mitropoliti Ioakeim 2, 81400 Myrina, Limnos, Greece.

Epidemiological studies have suggested a possible correlation between nutritional factors and gastrointestinal diseases. A case⁻control study was designed in order to investigate if functional foods consumption and Mediterranean diet adherence have a positive effect in ulcerative colitis, Crohn's disease, irritable bowel syndrome, and gastroesophageal reflux disease. In total, 142 patients (cases) and 147 gender-matched healthy people (controls) participated in the study. Read More

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http://dx.doi.org/10.3390/medicines6020050DOI Listing
April 2019
1 Read

Assessment of the Quality and Content of Clinical Practice Guidelines on Irritable Bowel Syndrome Using the AGREE II Instrument.

Digestion 2019 Apr 10:1-11. Epub 2019 Apr 10.

Evidence-Based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Lanzhou, China,

Objectives: The aim of the study was to assess the quality of guidelines on irritable bowel syndrome (IBS) using the Appraisal of Guidelines for Research and Evaluation II (AGREE II) instrument and identify concordance of different commendations.

Materials And Methods: A systematic search was undertaken from inception to May 2018. Two reviewers independently selected the titles and abstracts. Read More

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http://dx.doi.org/10.1159/000499838DOI Listing
April 2019
3 Reads

Constipation is associated with tension type headache in women.

Arq Neuropsiquiatr 2019 Mar;77(3):161-165

Bozok University, Faculty of Medicine, Department of Neurology, Yozgat, Turkey.

Tension-type headaches (TTH) and irritable bowel syndrome (IBS) are comorbid diseases affecting, especially, women. One of the underlying mechanisms for both is autonomic dysfunction in the brain-gut axis. We aimed to evaluate the factors accompanying TTH and their relation to functional gastrointestinal disorders. Read More

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S
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http://dx.doi.org/10.1590/0004-282X20190015DOI Listing
March 2019
5 Reads

[Gluten-free diet and low FODMAP diet: no or minor evidence for treating irritable bowel syndrome].

Authors:
Ahmed Madisch

Z Gastroenterol 2019 Apr 9;57(4):518-519. Epub 2019 Apr 9.

KRH Klinikum Siloah, Klinik für Gastroenterologie, interventionelle Endoskopie, Diabetologie und Akutgeriatrie, Hannover.

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http://dx.doi.org/10.1055/a-0828-5052DOI Listing

Functional Nutrition Treatment of Vulvodynia, Irritable Bowel Syndrome, and Depression: A Case Report.

Authors:
Jessica Drummond

Integr Med (Encinitas) 2018 Jun;17(3):44-51

A 34-y-old pregnant woman previously diagnosed with vulvodynia, irritable bowel syndrome (IBS), and depression used an elimination diet and nutritional supplementation-from 15 wk pregnant to 22 wk postpartum-to resolve her vulvodynia and IBS, and to reduce her use of antidepressant medication. This case demonstrates the potential usefulness of incorporating a customized functional nutritional approach to evaluate potential proinflammatory foods and nutritional insufficiencies in perinatal patients and postnatal patients. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396768PMC
June 2018
1 Read

Saponins regulate intestinal inflammation in colon cancer and IBD.

Pharmacol Res 2019 Apr 5;144:66-72. Epub 2019 Apr 5.

Dalian Medical University, Dalian 116044, China. Electronic address:

The saponins are natural surface-active glycosides which are the principal components of many popular herbal medicinal plants such as ginseng, astragalus, and bupleurum. Recent studies have suggested that saponins can exert strong anti-inflammatory effects and induce immune homeostasis in many diseases. Intestinal-inflammation-related digestive diseases include inflammatory bowel disease (IBD), irritable bowel syndrome, intestinal ischemia-reperfusion injury, necrotizing enterocolitis and radiation proctitis, as well as intestinal inflammation caused by nonsteroidal anti-inflammatory drugs. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10436618183196
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http://dx.doi.org/10.1016/j.phrs.2019.04.010DOI Listing
April 2019
3 Reads
4.408 Impact Factor

Characteristic dysbiosis of gut microbiota of Chinese patients with diarrhea-predominant irritable bowel syndrome by an insight into the pan-microbiome.

Chin Med J (Engl) 2019 Apr;132(8):889-904

State Key Laboratory for Turbulence and Complex Systems and Department of Biomedical Engineering, College of Engineering, Peking University, Beijing 100871, China.

Background: Irritable bowel syndrome (IBS) is reported associated with the alteration of gut microbial composition termed as dysbiosis. However, the pathogenic mechanism of IBS remains unclear, while the studies of Chinese individuals are scarce. This study aimed to understand the concept of dysbiosis among patients with Chinese diarrhea-predominant IBS (IBS-D), as a degree of variance between the gut microbiomes of IBS-D population and that of a healthy population. Read More

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http://dx.doi.org/10.1097/CM9.0000000000000192DOI Listing

RIFD - A brief clinical research interview for functional somatic disorders and health anxiety.

J Psychosom Res 2019 Apr 2. Epub 2019 Apr 2.

The Research Clinic for Functional Disorders and Psychosomatics, Aarhus University Hospital, Aarhus, Denmark.

Objective: Epidemiological research in functional somatic disorders such as irritable bowel syndrome, fibromyalgia, chronic fatigue syndrome, and bodily distress syndrome and related conditions such as health (illness) anxiety is often based on self-reported questionnaires or layman interviews. This study presents and describes the Research Interview for Functional somatic Disorders (RIFD) and provides first data regarding RIFD's ability to identify cases with functional somatic disorders and health anxiety in a two-phase design following self-reported symptom questionnaires.

Methods: RIFD was performed by phone by trained family physicians on a stratified subsample of 1590 adults from a Danish general population cohort (n = 7493). Read More

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http://dx.doi.org/10.1016/j.jpsychores.2019.04.001DOI Listing
April 2019
1 Read

Chronic Diarrhea and Constipation are More Common in Depressed Individuals.

Clin Gastroenterol Hepatol 2019 Apr 4. Epub 2019 Apr 4.

Department of Medicine, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, Massachusetts 02215, USA.

Background & Aims: Depression is a major health issue in the United States and is highly comorbid with gastrointestinal conditions. We collected data from the National Health and Nutrition Examination Survey (NHANES), a representative sample of the US population, to study the relationship between depression and bowel habits.

Methods: Using data from the NHANES (2009-2010), we identified 495 depressed and 4709 non-depressed adults who filled out the Bowel Health Questionnaire. Read More

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http://dx.doi.org/10.1016/j.cgh.2019.03.046DOI Listing

Provoked Vestibulodynia in Women with Pelvic Pain.

Sex Med 2019 Apr 3. Epub 2019 Apr 3.

BC Women's Center for Pelvic Pain and Endometriosis, Vancouver, British Columbia, Canada; Women's Health Research Institute, Vancouver, British Columbia, Canada; Department of Obstetrics and Gynaecology, University of British Columbia, Vancouver, British Columbia, Canada; BC Centre for Vulvar Health, Vancouver, British Columbia, Canada. Electronic address:

Introduction: Pelvic pain and vulvar pain are common conditions in women. In this study, we sought to characterize the clinical picture of patients with concurrent pelvic pain and provoked vestibulodynia (PVD).

Aim: To analyze the association between sexual/clinical characteristics and a diagnosis of PVD among women with pelvic pain. Read More

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http://dx.doi.org/10.1016/j.esxm.2019.03.002DOI Listing
April 2019
1 Read

A prospective study on incidence, risk factors, and validation of a risk score for post-infection irritable bowel syndrome in coastal eastern India.

Indian J Gastroenterol 2019 Apr 4. Epub 2019 Apr 4.

Department of Gastroenterology, S C B Medical College, Cuttack, 753 007, India.

Background And Aim: Post-infection irritable bowel syndrome (PI-IBS) can occur following acute gastroenteritis (AGE). This study was designed to evaluate the incidence and risk factors of PI-IBS following AGE and to validate a PI-IBS risk score.

Methods: This prospective study was performed between September 2014 and October 2016 on AGE patients by documenting their AGE severity and following up after 3 and 6 months to study the development of IBS (ROME III criteria). Read More

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http://dx.doi.org/10.1007/s12664-019-00943-wDOI Listing
April 2019
1 Read

Prebiotics in irritable bowel syndrome and other functional bowel disorders in adults: a systematic review and meta-analysis of randomized controlled trials.

Am J Clin Nutr 2019 Apr;109(4):1098-1111

Department of Nutritional Sciences, King's College London, London, United Kingdom.

Background: Irritable bowel syndrome (IBS) and other functional bowel disorders (FBDs) are prevalent disorders with altered microbiota. Prebiotics positively augment gut microbiota and may offer therapeutic potential.

Objectives: The aim of this study was to investigate the effect of prebiotics compared with placebo on global response, gastrointestinal symptoms, quality of life (QoL), and gut microbiota, via systematic review and meta-analysis of randomized controlled trials (RCTs) in adults with IBS and other FBDs. Read More

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http://dx.doi.org/10.1093/ajcn/nqy376DOI Listing
April 2019
1 Read

Investigation of the adsorption capacity of the enterosorbent Enterosgel for a range of bacterial toxins, bile acids and pharmaceutical drugs.

Sci Rep 2019 Apr 4;9(1):5629. Epub 2019 Apr 4.

TNK SILMA LLC, Shipilovskaya, Moscow, Russia.

Oral intestinal adsorbents (enterosorbents) are orally administered materials which pass through the gut where they bind (adsorb) various substances. The enterosorbent Enterosgel (Polymethylsiloxane polyhdrate) is recommended as a symptomatic treatment for acute diarrhoea and chronic diarrhoea associated with irritable bowel syndrome (IBS). Since 1980's there have been many Enterosgel clinical trials, however, the detailed mechanism of Enterosgel action towards specific toxins and interaction with concomitantly administered medications has not been fully investigated. Read More

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http://www.nature.com/articles/s41598-019-42176-z
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http://dx.doi.org/10.1038/s41598-019-42176-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449336PMC
April 2019
1 Read

Primary healthcare utilisation and self-rated health among patients with Irritable Bowel Syndrome: What are the impacts of comorbidities, gastrointestinal symptom burden, sense of coherence and stress?

J Psychosom Res 2019 Apr 25;119:1-7. Epub 2019 Jan 25.

Division of Gastroenterology, Department of Clinical and Experimental Medicine, Linköping University, Sweden.

Objectives: Irritable Bowel Syndrome (IBS) is a chronic gastrointestinal disease associated with impaired quality of life and an increased use of healthcare services. Self-ratings of health have proven a powerful predictor of health outcomes. The aim of this study was to evaluate the unique impacts of comorbidities, gastrointestinal symptoms, perceived stress and sense of coherence on the number of healthcare contacts and self-rated health of IBS patients in Swedish primary care. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00223999183087
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http://dx.doi.org/10.1016/j.jpsychores.2019.01.015DOI Listing
April 2019
3 Reads

Serotonin-estrogen interactions: what can we learn from pregnancy?

Biochimie 2019 Apr 1. Epub 2019 Apr 1.

INRS-Institut Armand-Frappier, 531, Boulevard des Prairies, Laval, QC, H7V 1B7, Canada; Center for Interdisciplinary Research on Well-Being, Health, Society and Environment (Cinbiose), Université Du Québec à Montréal, C.P.8888, Succ. Centre-Ville, Montréal, QC, H3C 3P8, Canada. Electronic address:

We have reviewed the scientific literature related to four diseases in which to serotonin (5-HT) is involved in the etiology, herein named 5-HT-linked diseases, and whose prevalence is influenced by estrogenic status: depression, migraine, irritable bowel syndrome and eating disorders. These diseases all have in common a sex-dimorphic prevalence, with women more frequently affected than men. The co-occurrence between these 5-HT-linked diseases suggests that they have common physiopathological mechanisms. Read More

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http://dx.doi.org/10.1016/j.biochi.2019.03.023DOI Listing

Fasting breath H2 and gut microbiota metabolic potential are associated with the response to a fermented milk product in irritable bowel syndrome.

PLoS One 2019 4;14(4):e0214273. Epub 2019 Apr 4.

Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Objectives: Aim of this study was to assess the effect of a fermented milk product containing Bifidobacterium lactis CNCM I-2494 (FMP) on gastrointestinal (GI) symptoms and exhaled H2 and CH4 during a nutrient and lactulose challenge in patients with irritable bowel syndrome (IBS).

Methods: We included 125 patients with IBS (Rome III). Fasted subjects were served a 400ml liquid test meal containing 25g lactulose. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214273PLOS
April 2019
2 Reads

Effects of Low-FODMAPS Diet on Irritable Bowel Syndrome Symptoms and Gut Microbiome.

Gastroenterol Nurs 2019 Mar/Apr;42(2):150-158

Han Su, MSN, RN, is PhD student, University of Washington School of Nursing, Seattle. Ya-Ting Li, MSN, RN, is PhD student, National Yang-Ming University School of Nursing, Taipei, Taiwan. Margaret M. Heitkemper, PhD, RN, is Professor, Department of Biobehavioral Nursing and Health Informatics, University of Washington, Seattle. Jasmine Zia, MD, is with the Division of Gastroenterology and Hepatology, Department of Medicine, University of Washington, Seattle.

Patients with irritable bowel syndrome (IBS) suffer from abdominal pain, bloating, and abnormal defecation. Reducing the dietary intake of fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAPs) has been shown to be beneficial in reducing IBS symptoms. However, diet modification plays an important role in the composition of colonic microbiota. Read More

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http://dx.doi.org/10.1097/SGA.0000000000000428DOI Listing
April 2019
2 Reads

Should We Use Tegaserod for Irritable Bowel Syndrome?

Am J Ther 2019 Mar 29. Epub 2019 Mar 29.

Department of Neurology, Stroke Unit, Johns Hopkins University, Towson, MD.

Background: Tegaserod, a serotonin (5-HT4) agonist initially approved for constipation but withdrawn from use in 2007 because of concerns about cardiovascular adverse effects, was resubmitted to the Food and Drug Administration (FDA) in 2018 for use in a restricted population.

Areas Of Uncertainty: Despite an 18-year regulatory history, there remain pharmacology and clinical trial concerns that have not been addressed but are critical for proper assessment of the drug safety and efficacy profile.

Sources: Original FDA reviews, FDA and developer advisory committee briefing documents, and published literature. Read More

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http://Insights.ovid.com/crossref?an=00045391-900000000-9847
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http://dx.doi.org/10.1097/MJT.0000000000000947DOI Listing
March 2019
3 Reads

Autonomic neurophysiologic implications of disorders comorbid with bladder pain syndrome vs myofascial pelvic pain.

Neurourol Urodyn 2019 Apr 4. Epub 2019 Apr 4.

Department of Neurology, Medical College of Wisconsin, Milwaukee, Wisconsin.

Aims: The neuropathophysiology of a debilitating chronic urologic pain condition, bladder pain syndrome (BPS), remains unknown. Our recent data suggests withdrawal of cardiovagal modulation in subjects with BPS, in contrast to sympathetic nervous system dysfunction in another chronic pelvic pain syndrome, myofascial pelvic pain (MPP). We evaluated whether comorbid disorders differentially associated with BPS vs MPP shed additional light on these autonomic differences. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/nau.23995
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http://dx.doi.org/10.1002/nau.23995DOI Listing
April 2019
2 Reads

Controversies and reality of the FODMAP diet for patients with irritable bowel syndrome.

J Gastroenterol Hepatol 2019 Mar 8. Epub 2019 Mar 8.

Department of Gastroenterology, The Alfred Hospital, Monash University, Melbourne, Victoria, Australia.

Since its first trial showing evidence of efficacy for managing symptoms of irritable bowel syndrome, the fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAP) diet has been gaining popularity but not without criticism. Application of the diet has changed from a rigid list of "allowed" and "not allowed" foods to a structured program of initial FODMAP restriction followed by food reintroduction and finally personalization so that patients are empowered to adjust their diet themselves to achieve good predictability of symptoms. Safety concerns of the diet have centered around its initial elimination leading to compromise of nutritional and psychological health, but careful patient assessment and management, preferably through a FODMAP-trained dietitian, will reduce the risk of such negative health outcomes. Read More

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http://dx.doi.org/10.1111/jgh.14650DOI Listing
March 2019
4 Reads

Gut Microbiota in Patients With Irritable Bowel Syndrome-a Systematic Review.

Gastroenterology 2019 Mar 30. Epub 2019 Mar 30.

Department of Medicine, Division of Gastroenterology & Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, Canada. Electronic address:

Background & Aims: Irritable bowel syndrome (IBS) is common but difficult to treat. Altering the gut microbiota has been proposed as a strategy for treatment of IBS, but the association between the gut microbiome and IBS symptoms has not been well established. We performed a systematic review to explore evidence for this association. Read More

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http://dx.doi.org/10.1053/j.gastro.2019.03.049DOI Listing
March 2019
1 Read

Psychological therapies (remotely delivered) for the management of chronic and recurrent pain in children and adolescents.

Cochrane Database Syst Rev 2019 Apr 2;4:CD011118. Epub 2019 Apr 2.

Cochrane Pain, Palliative and Supportive Care Group, Pain Research Unit, Churchill Hospital, Oxford, UK.

Background: This is the first update of a review published in 2015, Issue 1. Chronic pain is common during childhood and adolescence and is associated with negative outcomes, such as increased severity of pain, reduced function, and low mood. Psychological therapies, traditionally delivered face-to-face with a therapist, are efficacious at reducing pain intensity and disability. Read More

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http://dx.doi.org/10.1002/14651858.CD011118.pub3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445568PMC
April 2019
3 Reads

The experiences of physical activity in Irritable Bowel Syndrome - A qualitative study.

J Clin Nurs 2019 Apr 2. Epub 2019 Apr 2.

Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, PO Box 428, 405 30, Göteborg, Sweden.

Aims And Objectives: The aim of this study was to explore experiences of physical activity in patients with Irritable bowel syndrome.

Bakground: Irritable bowel syndrome is a common functional bowel disorder. The knowledge of physical activity in Irritable bowel syndrome is limited and has not been qualitatively studied before. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jocn.14880
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http://dx.doi.org/10.1111/jocn.14880DOI Listing
April 2019
2 Reads

Elimination of Fermentable Carbohydrates to Reduce Gastrointestinal Symptoms in Pediatric Patients With Irritable Bowel Syndrome: A Narrative Review.

Nutr Clin Pract 2019 Apr 1. Epub 2019 Apr 1.

Department of Clinical and Preventive Nutrition Sciences, School of Health Professions, Rutgers University, Newark, New Jersey, USA.

Irritable bowel syndrome (IBS) is classified as a functional gastrointestinal (GI) disorder characterized by abdominal pain, bloating, and changes in bowel function. Although the pathophysiology of IBS is incompletely understood, fermentable carbohydrates are implicated as a potential cause of symptoms. An elimination diet, such as a low-FODMAP (fermentable oligosaccharides, disaccharides, monosaccharides, and polyols) diet, represents a potential intervention for reducing GI symptoms in patients with IBS. Read More

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http://dx.doi.org/10.1002/ncp.10269DOI Listing
April 2019
1 Read

Can Sertraline and Nortriptyline Protect the Neurons in Submucosal and Myenteric Plexuses of Rat's Colon Against Stress?

Dig Dis Sci 2019 Apr 1. Epub 2019 Apr 1.

Histomorphometry and Stereology Research Center, Shiraz University of Medical Sciences, Zand Ave., Shiraz, 71348-45794, Iran.

Background: The colon is partly controlled by myenteric and submucosal plexuses, which respond to stress and lead to some gastrointestinal disorders. These plexuses play roles in irritable bowel syndrome. Patients suffering from this syndrome can be treated with some antidepressants, including sertraline and nortriptyline. Read More

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http://dx.doi.org/10.1007/s10620-019-05600-yDOI Listing

Expression and clinical significance of 5-HT and 5-HTR in the intestinal mucosa of patient with diarrhea-type irritable bowel syndrome.

Exp Ther Med 2019 Apr 22;17(4):3077-3082. Epub 2019 Feb 22.

Department of Adverse Drug Reaction Monitoring, Zhejiang Province Center of Adverse Drug Reaction Monitoring, Hangzhou, Zhejiang 310012, P.R. China.

Expression levels and clinical significance of 5-HT and 5-HTR in the intestinal mucosa tissue of patients with diarrhea-type irritable bowel syndrome (D-IBS) were investigated. A retrospective analysis was performed on 46 tissue specimens (observation group) of the intestinal mucosa of patients with D-IBS, who were diagnosed in the Tongde Hospital of Zhejiang Province and received colonoscopy from March 2016 to December 2017, and 18 tissue specimens (control group) of the intestinal mucosa of healthy subjects who received physical examinations. The expression levels of 5-HT and 5-HTR in the intestinal mucosa tissue of patients in the observation and control group were detected by ELISA, and the relationship between 5-HT, 5-HTR and the clinicopathological parameters of patients with D-IBS was analyzed. Read More

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http://dx.doi.org/10.3892/etm.2019.7297DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434247PMC
April 2019
3 Reads

Dehydroepiandrosterone sulfate improves visceral sensation and gut barrier in a rat model of irritable bowel syndrome.

Eur J Pharmacol 2019 Mar 29;852:198-206. Epub 2019 Mar 29.

Division of Gastroenterology and Hematology/Oncology, Department of Medicine, Asahikawa Medical University, 2-1-1-1 Midorigaoka-Higashi, Asahikawa, Hokkaido, 078-8510, Japan; Department of General Medicine, Asahikawa Medical University, Midorigaoka Higashi 2-1-1-1, Asahikawa, 078-8510, Japan. Electronic address:

Stress-induced altered visceral sensation and impaired gut barrier play an important role in the pathophysiology of irritable bowel syndrome (IBS). These responses were demonstrated to be peripheral corticotropin-releasing factor (CRF) dependent and also mediated via proinflammatory cytokine in animal IBS model. Dehydroepiandrosterone sulfate (DHEA-S) is known to have anti-inflammatory properties by suppressing proinflammatory cytokine release. Read More

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http://dx.doi.org/10.1016/j.ejphar.2019.03.037DOI Listing

Probiotics, prebiotics, and low FODMAP diet for irritable bowel syndrome - What is the current evidence?

Complement Ther Med 2019 Apr 16;43:73-80. Epub 2019 Jan 16.

School of Biomedical Sciences, Charles Sturt University, Bathurst, NSW 2795, Australia. Electronic address:

Irritable bowel syndrome (IBS) is one of the most common functional gastrointestinal disorders worldwide. While the pathogenesis is not clearly understood, current research points to the role of the gut microbiome and alterations in the diversity of the microbiota. Probiotics, prebiotics, and low FODMAP diet are therapeutic means associated with modification of the gut microbiome for the alleviation of IBS symptoms. Read More

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http://dx.doi.org/10.1016/j.ctim.2019.01.010DOI Listing
April 2019
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Glutamatergic Signaling Along The Microbiota-Gut-Brain Axis.

Int J Mol Sci 2019 Mar 25;20(6). Epub 2019 Mar 25.

Department of Medicine and Surgery, University of Insubria, via H Dunant 5, 21100 Varese, Italy.

A complex bidirectional communication system exists between the gastrointestinal tract and the brain. Initially termed the "gut-brain axis" it is now renamed the "microbiota-gut-brain axis" considering the pivotal role of gut microbiota in maintaining local and systemic homeostasis. Different cellular and molecular pathways act along this axis and strong attention is paid to neuroactive molecules (neurotransmitters, i. Read More

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https://www.mdpi.com/1422-0067/20/6/1482
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http://dx.doi.org/10.3390/ijms20061482DOI Listing
March 2019
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The potential probiotic Lactobacillus rhamnosus CNCM I-3690 strain protects the intestinal barrier by stimulating both mucus production and cytoprotective response.

Sci Rep 2019 Apr 1;9(1):5398. Epub 2019 Apr 1.

INRA, Commensal and Probiotics-Host Interactions Laboratory, Micalis Institute, INRA, AgroParisTech, Université Paris-Saclay, 78350, Jouy-en-Josas, France.

The gut barrier plays an important role in human health. When barrier function is impaired, altered permeability and barrier dysfunction can occur, leading to inflammatory bowel diseases, irritable bowel syndrome or obesity. Several bacteria, including pathogens and commensals, have been found to directly or indirectly modulate intestinal barrier function. Read More

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http://dx.doi.org/10.1038/s41598-019-41738-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443702PMC
April 2019
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Changes of the postcentral cortex in irritable bowel syndrome patients.

Brain Imaging Behav 2019 Mar 29. Epub 2019 Mar 29.

School of Information Technology and Electrical Engineering, University of Queensland, QLD, Brisbane, 4072, Australia.

The postcentral cortex (poCC) is commonly found to respond to visceral stimulation, but researchers usually pay less attention to this role of the poCC in the patients with functional gastrointestinal disorders, because it is a primary receptor for general bodily feeling of touch, such as temperature and pain. The current study focuses on the changes around the poCC in irritable bowel syndrome (IBS) patients based on the resting-state functional magnetic resonance imaging, aiming to investigate whether the poCC-centric brain metrics may be directly related to visceral perception. In the study, we calculated the regional homogeneity, seed-based correlation (SBC) and nodal centralities of the poCC to explore the changes in the regional activity and information flow around the poCC in IBS patients. Read More

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http://dx.doi.org/10.1007/s11682-019-00087-7DOI Listing
March 2019
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Beneficial effects and potential risks of tomato consumption for human health: An overview.

Nutrition 2019 Jan 25;62:201-208. Epub 2019 Jan 25.

Food Safety Research Center (salt), Semnan University of Medical Sciences, Semnan, Iran; Institute for Research and Innovation in Health (i3S), University of Porto, Porto, Portugal. Electronic address:

Tomato and its derived products have a very interesting nutritional value in addition to prominent antioxidant, anti-inflammatory, and anticancer activities. In terms of tomatoes are generally quite safe to eat. However, overall consumption varies from individual to individual. Read More

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http://dx.doi.org/10.1016/j.nut.2019.01.012DOI Listing
January 2019
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2.926 Impact Factor

Gut Prevotella as a possible biomarker of diet and its eubiotic versus dysbiotic roles-A comprehensive literature review.

Br J Nutr 2019 Mar 29:1-24. Epub 2019 Mar 29.

Faculty of Food Science and Technology,Institute of Life Sciences,University of Agricultural Sciences and Veterinary Medicine,Cluj-Napoca, CJ,Romania.

Gut microbiota has a profound impact on human health. Emerging data shows that dietary patterns are associated with different communities of bacterial species within the gut. Prevotella species have been correlated with plant rich diets, abundant in carbohydrates and fibres. Read More

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http://dx.doi.org/10.1017/S0007114519000680DOI Listing
March 2019
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Similarities and differences between IBS-C and FC with regards to symptomatology, sleep quality and psychological attributes.

J Formos Med Assoc 2019 Mar 25. Epub 2019 Mar 25.

Department of Medicine, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Tzu Chi University, Hualien, Taiwan. Electronic address:

Background: Irritable bowel syndrome (IBS) and functional constipation (FC) are highly prevalent in the general population and have significant symptom overlap, while the clinical associations and psychological links between IBS and FC remains poorly understood. We aimed to compare the clinical, metabolic and psychological factors between patients with FC patients and constipation predominated IBS.

Methods: We consecutively enrolled 360 patients from the outpatient clinics of Hualien Tzu Chi medical center. Read More

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http://dx.doi.org/10.1016/j.jfma.2019.02.017DOI Listing
March 2019
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Quercetin Attenuates Visceral Hypersensitivity and 5-Hydroxytryptamine Availability in Postinflammatory Irritable Bowel Syndrome Rats: Role of Enterochromaffin Cells in the Colon.

J Med Food 2019 Mar 28. Epub 2019 Mar 28.

4 Lab of Brain and Gut Research, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China.

Intestinal enterochromaffin (EC) cell hyperplasia and increased 5-hydroxytryptamine (5-HT) availability play key roles in the pathogenesis of abdominal hypersensitivity of irritable bowel syndrome (IBS). This study aims to study the effect of quercetin on visceral pain and 5-HT availability in postinflammatory IBS (PI-IBS) rats. PI-IBS model rats were administered quercetin by gavage at doses of 5, 10, and 20 mg/kg for 14 days. Read More

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http://dx.doi.org/10.1089/jmf.2018.4264DOI Listing

How can we develop better antispasmodics for irritable bowel syndrome?

Expert Opin Drug Discov 2019 Mar 28:1-14. Epub 2019 Mar 28.

d Department of Toxicology and Pharmacology, Faculty of Pharmacy , Tehran University of Medical Sciences , Tehran , Iran.

Introduction: Irritable bowel syndrome (IBS) is a prevalent gastrointestinal (GI) disease. Antispasmodics are a heterogeneous group of drugs that tackle IBS-associated altered bowel habit and abdominal pain. However, some studies have shown their failure to exhibit benefit over placebo. Read More

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http://dx.doi.org/10.1080/17460441.2019.1593369DOI Listing
March 2019
2 Reads