16,676 results match your criteria Irritable Bowel Syndrome


Microbiome and Gut Dysbiosis.

Exp Suppl 2018 ;109:459-476

Department of Gastroenterology of Medical School, University of Sao Paulo, São Paulo, Brazil.

The gastrointestinal (GI) tract is the residence of trillions of microorganisms that include bacteria, archaea, fungi and viruses. The collective genomes of whole microbial communities (microbiota) integrate the gut microbiome. Up to 100 genera and 1000 distinct bacterial species were identified in digestive tube niches. Read More

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January 2018

Aluminum Ingestion Promotes Colorectal Hypersensitivity in Rodents.

Cell Mol Gastroenterol Hepatol 2019 20;7(1):185-196. Epub 2018 Sep 20.

Université Lille, INSERM, CHR Lille, Lille Inflammation Research International Center, U995, Lille, France.

Background & Aims: Irritable bowel syndrome (IBS) is a multifactorial disease arising from a complex interplay between genetic predisposition and environmental influences. To date, environmental triggers are not well known. Aluminum is commonly present in food, notably by its use as food additive. Read More

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September 2018

Influence of the requirement for abdominal pain in the diagnosis of irritable bowel syndrome with constipation (IBS-C) under the Rome IV criteria using data from a large Japanese population-based internet survey.

Biopsychosoc Med 2018 5;12:18. Epub 2018 Dec 5.

4Department of Behavioral Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.

Background: Rome III was revised to Rome IV in May 2016. One important change in the Rome IV criteria is that abdominal pain must be present for a diagnosis of irritable bowel syndrome (IBS). Under Rome III, in contrast, patients with abdominal discomfort only could be diagnosed with IBS, but these cases under Rome IV are now classified as unspecified functional bowel disorder (FBD). Read More

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December 2018

A Case of Sjögren's Syndrome Mimicking Inflammatory Myopathy.

Cureus 2018 Oct 1;10(10):e3393. Epub 2018 Oct 1.

Neurology, Keck School of Medicine of the University of Southern California, Los Angeles, USA.

Sjögren's syndrome (SS) is a chronic autoimmune disorder, characterized by lymphocytic infiltration of exocrine glands and causing the decreased function of lacrimal and salivary glands. We describe a case of a 34-year-old male who presented with Sjögren's syndrome presenting as myopathy and sensorimotor neuropathy. His creatinine kinase levels were elevated with positive anti-Sjögren's syndrome-related antigen A autoantibodies and anti-Sjögren's syndrome Type B autoantibodies. Read More

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October 2018

Medically Unexplained Physical Symptoms in Hospitalized Patients: A 9-Year Retrospective Observational Study.

Front Psychiatry 2018 23;9:626. Epub 2018 Nov 23.

Section of Psychiatry, Department of Medicine and Surgery, University of Insubria, Varese, Italy.

"Medically Unexplained Physical Symptoms" (MUPS) defines a subgroup of patients presenting physical symptoms of unclear origin. The study aims to profile clinical and socio-demographic characteristics of patients with MUPS. This 9-years observational retrospective study assesses all patients admitted between 2008 and 2016 in the divisions of neurology and gastroenterology. Read More

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November 2018

[Affective temperaments in drug addicts: A case-control study].

Encephale 2018 Dec 5. Epub 2018 Dec 5.

Service de psychiatrie C, CHU Hédi-Chaker de Sfax, faculté de médecine de Sfax, Tunisie.

Introduction: The study of affective temperaments is a dimensional approach to personality that would provide a better understanding of the emergence of psychopathological disorders including addictive behaviors. However, in the literature, there is a lack of studies focusing on the links between this type of disorder and affective temperaments. Our objectives were to study the distribution of the five known affective temperaments in a group of drug addicts compared to a control group, and to identify sociodemographic and clinical factors associated with emotional traits. Read More

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December 2018

Psychometric evaluation of a patient-reported outcome measure in pancreatic exocrine insufficiency (PEI).

Pancreatology 2018 Nov 27. Epub 2018 Nov 27.

University Medicine Greifswald, Greifswald, Germany.

Background/objectives: Pancreatic exocrine insufficiency (PEI) is commonly caused by chronic pancreatitis (CP) or cystic fibrosis (CF). There are no PEI-specific patient-reported assessments of symptoms and impacts. The PEI Questionnaire (PEI-Q) was developed through qualitative research with PEI patients and expert clinical input. Read More

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November 2018
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Bifidobacterium infantis M-63 improves mental health in victims with irritable bowel syndrome developed after a major flood disaster.

Benef Microbes 2018 Dec 10:1-10. Epub 2018 Dec 10.

1 School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu 16150, Kelantan, Malaysia.

Individuals in a community who developed irritable bowel syndrome (IBS) after major floods have significant mental health impairment. We aimed to determine if Bifidobacterium infantis M-63 was effective in improving symptoms, psychology and quality of life measures in flood-affected individuals with IBS and if the improvement was mediated by gut microbiota changes. Design was non-randomised, open-label, controlled before-and-after. Read More

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December 2018

Consensus document on exclusion diets in irritable bowel syndrome (IBS).

Nutr Hosp 2018 Dec 3;35(6):1450-1466. Epub 2018 Dec 3.

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This paper summarizes the contents of a consensus document on exclusion diets in irritable bowel disease that was developed by a task force from SEPD, FEAD, SENPE, FESNAD, SEÑ, SEEN, SEGHNP, SEDCA and ADENYD. The complete document is available at the FEAD and in SENPE websites. Irritable bowel syndrome is a highly prevalent functional digestive disorder where, in addition to drugs, therapy includes diet and acquisition of healthy habits as basic elements for its control. Read More

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December 2018

Distribution, projections and association with calbindin baskets of motor neurons, interneurons and sensory neurons in guinea-pig distal colon.

J Comp Neurol 2018 Dec 6. Epub 2018 Dec 6.

College of Medicine and Public Health & Centre for Neuroscience, Flinders University, Australia.

Normal gut function relies on the activity of the enteric nervous system (ENS) found within the wall of the gastrointestinal tract. The structural and functional organisation of the ENS has been extensively studied in the guinea pig small intestine, but less is known about colonic circuitry. Given that there are significant differences between these regions in function, observed motor patterns and pathology, it would be valuable to have a better understanding of the colonic ENS. Read More

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December 2018
1 Read

Thailand Dyspepsia Guidelines: 2018.

J Neurogastroenterol Motil 2018 Nov 23. Epub 2018 Nov 23.

Department of Medicine, Faculty of Medicine, Chulalongkorn University and KingChulalongkorn Memorial Hospital, Thai Red Cross, Bangkok, Thailand.

The management of dyspepsia in limited-resource areas has not been established. In 2017, key opinion leaders throughout Thailand gathered to review and evaluate the current clinical evidence regarding dyspepsia and to develop consensus statements, rationales, levels of evidence, and grades of recommendation for dyspepsia management in daily clinical practice based on the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) approach. This guideline is mainly focused on the following four topics: (1) evaluation of patients with dyspepsia, (2) management, (3) special issues (overlapping gastroesophageal reflux disease/irritable bowel syndrome and non-steroidal anti-inflammatory drug/aspirin use), and (4) long-term follow-up and management to provide guidance for physicians in Thailand and other limited-resource areas managing such patients. Read More

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November 2018
1 Read

Effect of dietary additives on intestinal permeability in both and a human cell co-culture.

Dis Model Mech 2018 Nov 28;11(12). Epub 2018 Nov 28.

Department of Biological Sciences, Binghamton University, Binghamton, New York 13902, USA

Increased intestinal barrier permeability has been correlated with aging and disease, including type 2 diabetes, Crohn's disease, celiac disease, multiple sclerosis and irritable bowel syndrome. The prevalence of these ailments has risen together with an increase in industrial food processing and food additive consumption. Additives, including sugar, metal oxide nanoparticles, surfactants and sodium chloride, have all been suggested to increase intestinal permeability. Read More

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November 2018
1 Read

Clinical and Cost Effectiveness of Online Cognitive Behavioral Therapy in Children with Functional Abdominal Pain Disorders.

Clin Gastroenterol Hepatol 2018 Nov 28. Epub 2018 Nov 28.

Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden; Department of Pediatric Gastroenterology and Nutrition, Sachs' Children's Hospital, Stockholm, Sweden.

Background & Aims: Scalable and effective treatments are needed for children with functional abdominal pain disorders (FAPDs). We performed a randomized controlled trial of the efficacy and cost effectiveness of cognitive behavioral therapy delivered online (internet CBT) compared to usual therapy.

Methods: We studied children (8-12 years old) diagnosed with FAPDs, based on the Rome IV criteria, in Sweden from September 2016 through April 2017. Read More

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November 2018

Probiotics on Pediatric Functional Gastrointestinal Disorders.

Nutrients 2018 Nov 29;10(12). Epub 2018 Nov 29.

Department of Pediatrics, University of Turku, 20521 Turku, Finland.

The potential association between gut microbiota perturbations and childhood functional gastrointestinal disturbances opens interesting therapeutic and preventive possibilities with probiotics. The aim of this review was to evaluate current evidence on the efficacy of probiotics for the management of pediatric functional abdominal pain disorders, functional constipation and infantile colic. Thus far, no single strain, combination of strains or synbiotics can be recommended for the management of irritable bowel syndrome, functional abdominal pain or functional constipation in children. Read More

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November 2018
1 Read

The Role of Disaccharidase Deficiencies in Functional Abdominal Pain Disorders-A Narrative Review.

Nutrients 2018 Nov 29;10(12). Epub 2018 Nov 29.

Department of Pediatric Gastroenterology, Hepatology and Nutrition, University of Miami Miller School of Medicine, 1601 NW 12th Ave, Miami, FL 33137, USA.

Disaccharidase deficiencies are reportedly underdiagnosed in pediatric populations. Though typically thought to cause diarrheal disease, they can also be a cause of abdominal pain and dyspepsia, and patients diagnosed with these functional disorders may actually have associated enzyme deficiencies. While the effects of lactose deficiency have been widely studied, sucrase, maltase, and isomaltase are less frequently considered when approaching a patient with an apparent functional abdominal pain disorder. Read More

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November 2018

New Protocol for Production of Reduced-Gluten Wheat Bread and Pasta and Clinical Effect in Patients with Irritable Bowel Syndrome: A randomised, Double-Blind, Cross-Over Study.

Nutrients 2018 Dec 2;10(12). Epub 2018 Dec 2.

Faculty of Science and Technology, Free University of Bolzano, piazza Università, 5, 39100 Bolzano, Italy.

It has been suggested that sourdough fermented products have beneficial health effects. Fungal proteases and selected sourdough lactic acid bacteria were used to produce wheat bread and pasta with a reduced-gluten content (<50% of traditional products). Fermentable oligo-, di- and mono- saccharides and polyols and amylase/trypsin inhibitors were also evaluated. Read More

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December 2018

Association of the Vitamin D Level and Quality of School Life in Adolescents with Irritable Bowel Syndrome.

J Clin Med 2018 Dec 1;7(12). Epub 2018 Dec 1.

Department of Pediatrics, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam 13496, Korea.

There is no treatment of choice for irritable bowel syndrome, which affects up to 20% of school-aged children. This cross-sectional study evaluated the difference in the average vitamin D level between subtypes of irritable bowel syndrome, and the relationship between the vitamin D level as well as the severity of irritable bowel syndrome symptoms. We included 124 adolescents aged 10⁻17 years (68 boys, 56 girls; mean age 12. Read More

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December 2018
1 Read

microRNA-15 Activates NF-κB Pathway via Down Regulating Expression of Adenosine A2 Receptor in Ulcerative Colitis.

Authors:
Huixia Zhang Wei Li

Cell Physiol Biochem 2018 4;51(4):1932-1944. Epub 2018 Dec 4.

Department of Physiology and neurobiology, School of Basic Medicine Sciences, Zhengzhou University, Zhengzhou, China.

Background/aims: The role of miR-15 in ulcerative colitis (UC) is unclear. In this study, we found that miR-15 downregulated the expression of adenosine A2a receptor (A2aAR) in the colonic tissues of patients with UC and in HT-29 human colonic epithelial cells.

Methods: The study population comprised patients with UC (n=23), irritable bowel syndrome (IBS, n=22), and healthy subjects (n = 20). Read More

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December 2018
1 Read
2.875 Impact Factor

Living with an irritable bowel syndrome

Rev Prat 2017 12;67(10):1095-1096

Association des patients souffrant du syndrome de l'intestin irritable.

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December 2017

Efficacy and safety of APT036 versus simethicone in the treatment of functional bloating: a multicentre, randomised, double-blind, parallel group, clinical study.

Transl Gastroenterol Hepatol 2018 25;3:72. Epub 2018 Sep 25.

Internal Medicine & Gastroenterology Department, University Emergency Hospital, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.

Background: Bloating is a common symptom reported by around 16% to 31% of the general population. Functional bloating is diagnosed in patients with recurrent symptoms of bloating who do not meet the diagnostic criteria of irritable bowel syndrome or other functional gastrointestinal disorders.

Methods: This double-blind, multicentre, randomised study compared the safety and efficacy of APT036 (xyloglucan plus tyndallized and ; Aprotecol) and simethicone in treating functional bloating in adults. Read More

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September 2018
1 Read

Serum-derived bovine immunoglobulin for children with diarrhea-predominant irritable bowel syndrome.

Pediatric Health Med Ther 2018 24;9:129-133. Epub 2018 Oct 24.

Department of Pediatrics, Louisiana State University, New Orleans, LA 70118, USA,

Background: Oral serum-derived bovine immunoglobulin (SBI)/protein isolate is a medical food intended to manage chronic diarrhea. It has been shown to improve pain and diarrhea in adults with diarrhea-predominant irritable bowel syndrome (d-IBS).

Aim: To determine if SBI can improve symptoms in children with d-IBS. Read More

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October 2018
3 Reads

Role of guar fiber in improving digestive health and function.

Nutrition 2018 Aug 23;59:158-169. Epub 2018 Aug 23.

GSK Italy, Origgio, Varese, Italy.

Digestive health plays key role in our active daily life; but maintaining proper bowel movements, i.e., being free from constipation, diarrhea, irritable bowel syndrome, inflammatory bowel disease, flatulence, bloating, and abdominal pain, is complex. Read More

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August 2018
2 Reads

Women's Experiences of Intimate Relationships While Living With Irritable Bowel Syndrome.

Gastroenterol Nurs 2018 Nov/Dec;41(6):516-524

Megan Nguyen, MN, BScN, RN, is PhD Student, University of Toronto, Toronto, Ontario, Canada. Margaret M. Malone, PhD, MA, RN, BAAN, is Professor, Ryerson University, Toronto, Ontario, Canada. Annette Bailey, PhD, MSN, BScN, RN, is Professor, Ryerson University, Toronto, Ontario, Canada. Jennifer Lapum, PhD, MN, BScN, RN, is Professor, Ryerson University, Toronto, Ontario, Canada.

Irritable bowel syndrome is a chronic digestive disorder that commonly affects women. Research has shown that the illness experience of irritable bowel syndrome can disrupt social relationships. However, the area of intimate relationships has yet to be explored despite the deep involvement that intimate partners often have in the experience of living with chronic illness. Read More

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November 2018

Whole Fruits and Fruit Fiber Emerging Health Effects.

Authors:
Mark L Dreher

Nutrients 2018 Nov 28;10(12). Epub 2018 Nov 28.

Nutrition Science Solutions, LLC, Wimberley, 78676 TX, USA.

Less than 10% of most Western populations consume adequate levels of whole fruits and dietary fiber with typical intake being about half of the recommended levels. Evidence of the beneficial health effects of consuming adequate levels of whole fruits has been steadily growing, especially regarding their bioactive fiber prebiotic effects and role in improved weight control, wellness and healthy aging. The primary aim of this narrative review article is to examine the increasing number of health benefits which are associated with the adequate intake of whole fruits, especially fruit fiber, throughout the human lifecycle. Read More

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November 2018
4 Reads

Optimal cut-off value of fecal calprotectin for the evaluation of ulcerative colitis: An unsolved issue?

JGH Open 2018 Oct 10;2(5):207-213. Epub 2018 Aug 10.

Department of Gastroenterology Indira Gandhi Institute of Medical Sciences Patna India.

Introduction: There is variability in the fecal calprotectin (FCP) cut-off level for the prediction of ulcerative colitis (UC) disease activity and differentiation from irritable bowel disease (IBS-D). The FCP cut-off levels vary from country to country.

Aims: We aimed to assess FCP as a marker of disease activity in patients with UC. Read More

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October 2018
7 Reads

Early experience with a low FODMAP diet in Asian patients with irritable bowel syndrome.

JGH Open 2018 Oct 6;2(5):178-181. Epub 2018 Jul 6.

Division of Gastroenterology, Department of Medicine, Faculty of Medicine University of Malaya Kuala Lumpur Malaysia.

Background: The efficacy and acceptance of a low fermentable oligosaccharides, disaccharides, monosaccharides and polyols (FODMAP) diet in Asian adults with irritable bowel syndrome (IBS) remain uncertain. We aimed to describe our early experience in a single center with a dedicated gastroenterology dietetic service.

Methods: Consecutive patients with IBS referred to our dedicated Dietetic Gastroenterology Clinic between February 2016 and May 2016 were screened. Read More

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October 2018
2 Reads

Low FODMAP diet in Egyptian patients with Crohn's disease in remission phase with functional gastrointestinal symptoms.

JGH Open 2018 Feb 5;2(1):15-20. Epub 2018 Feb 5.

Gastroenterology Unit, Faculty of Medicine Alexandria University Alexandria Egypt.

Background And Aim: Despite being in remission, functional gastrointestinal disease (FGID) in Crohn's disease (CD) patients can reduce their quality of life. The Egyptian daily diet contains a high amount of FODMAP (Fermentable Oligosaccharides, Disaccharides, Monosaccharides, And Polyols). As the low FODMAP diet has been proven to be effective in irritable bowel syndrome worldwide, it was reasonable to take a step further and begin to study the effect of low FODMAP in Egyptian CD patients with FGID. Read More

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February 2018
1 Read

Referrals to a tertiary hospital: A window into clinical management issues in functional gastrointestinal disorders.

JGH Open 2017 Nov 31;1(3):84-91. Epub 2017 Oct 31.

Department of Medicine, The University of Adelaide Adelaide South Australia Australia.

Background And Aim: To investigate the quality of and reasons for referrals of patients with likely functional gastrointestinal disorders (FGID) and explore patients' experience of clinical management.

Methods: A cross sectional, mixed-methods study was undertaken. Referrals (July 2013-2015) to one gastroenterology outpatient department triaged as "likely FGID", the referred patients and their referring primary healthcare providers were examined. Read More

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November 2017

Can Infection Impair the Diagnostic Level of Fecal Calprotectin in Patients with Inflammatory Bowel Disease? A Case Report.

Iran J Parasitol 2018 Jul-Sep;13(3):505-509

Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Inflammatory bowel disease (IBD) is attributed to complex conditions of gastrointestinal tract that is frequently reported all over the world. Fecal calprotectin evaluation is described as a primary tool to screen IBD patients. There are reports showing the confounding role of some microbial agents in diagnostic levels of calprotectin. Read More

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November 2018
3 Reads

The possible role of bacteria, viruses, and parasites in initiation and exacerbation of irritable bowel syndrome.

J Cell Physiol 2018 Nov 27. Epub 2018 Nov 27.

Department of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Irritable bowel syndrome (IBS) is a prolonged and disabling functional gastrointestinal disorder with the incidence rate of 18% in the world. IBS could seriously affect lifetime of patients and cause high economic burden on the community. The pathophysiology of the IBS is hardly understood, whereas several possible mechanisms, such as visceral hypersensitivity, irregular gut motility, abnormal brain-gut relations, and the role of infectious agents, are implicated in initiation and development of this syndrome. Read More

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November 2018
5 Reads

Colonic Proteome Signature in Immunoproteasome-Deficient Stressed Mice and Its Relevance for Irritable Bowel Syndrome.

J Proteome Res 2018 Nov 26. Epub 2018 Nov 26.

INSERM unit 1073 , Normandie University, UNIROUEN , 22 boulevard Gambetta , Rouen , F-76183 , France.

A role for immunoproteasome in the regulation of intestinal permeability has been previously suggested both in mice during water avoidance stress (WAS) and in patients with irritable bowel syndrome (IBS). Here, we provide evidence that the ubiquitin-proteasome system (UPS) contributes to the pathophysiology of IBS. Indeed, we report that colonic proteome is altered in WAS mice and that β2i subunit deficiency modifies the proteome response that is associated with a limitation of colonic hyperpermeability. Read More

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November 2018

Efficacy of individual and group hypnotherapy in irritable bowel syndrome (IMAGINE): a multicentre randomised controlled trial.

Lancet Gastroenterol Hepatol 2019 Jan 23;4(1):20-31. Epub 2018 Nov 23.

Julius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht, Utrecht, Netherlands.

Background: Hypnotherapy for irritable bowel syndrome (IBS) has been used primarily in patients with refractory symptoms in specialised departments and delivered on an individual basis. We aimed to test the hypothesis that hypnotherapy would be more effective than educational supportive therapy, and that group hypnotherapy would be non-inferior to individual hypnotherapy for patients with IBS referred from primary and secondary care.

Methods: We did a multicentre randomised controlled trial (IMAGINE) in 11 hospitals in the Netherlands. Read More

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January 2019

Is hypnotherapy helpful for irritable bowel syndrome in primary and secondary care?

Authors:
Olafur S Palsson

Lancet Gastroenterol Hepatol 2019 Jan 23;4(1):2-3. Epub 2018 Nov 23.

Division of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27515, USA. Electronic address:

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January 2019

Experiences of the effects of physical activity in persons with irritable bowel syndrome (IBS): a qualitative content analysis.

Scand J Gastroenterol 2018 Nov 25:1-7. Epub 2018 Nov 25.

a Institute of Medicine, Sahlgrenska Academy , University of Gothenburg , Göteborg , Sweden.

Objective: Increased physical activity has been tested among patients with irritable bowel syndrome (IBS) in a randomized trial which demonstrated improvement in gastrointestinal (GI) symptoms. The patients' experiences of the effects of physical activity on IBS symptoms are unknown. This knowledge is necessary to enable suitable support from health care professionals. Read More

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November 2018
3 Reads

Interactions between gut permeability and brain structure and function in health and irritable bowel syndrome.

Neuroimage Clin 2018 Nov 17. Epub 2018 Nov 17.

Center for Medical Image Science and Visualization (CMIV), Linköping University/US, 581 85 Linköping, Sweden; Department of Clinical and Experimental Medicine, Linköping University, 581 83 Linköping, Sweden; Department of Gastroenterology, Linköping University Hospital, 581 85 Linköping, Sweden.

Changes in brain-gut interactions have been implicated in the pathophysiology of chronic visceral pain in irritable bowel syndrome (IBS). Different mechanisms of sensitization of visceral afferent pathways may contribute to the chronic visceral pain reports and associated brain changes that characterize IBS. They include increased gut permeability and gut associated immune system activation, and an imbalance in descending pain inhibitory and facilitatory mechanisms. Read More

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November 2018
1 Read

Irritable Bowel Syndrome: What Treatments Really Work.

Med Clin North Am 2019 Jan;103(1):137-152

Department of Medicine, Division of Gastroenterology, Johns Hopkins University, 4940 Eastern Avenue, 3rd Floor, Baltimore, MD 21224, USA. Electronic address:

Irritable bowel syndrome (IBS) is present in patients with symptoms of chronic abdominal pain and altered bowel habits but no identifiable organic etiology. Rome IV classification groups patients based on predominant stool pattern. Low-FODMAP diets have been helpful in providing symptom relief, as have cognitive behavioral and mind-body techniques that help patients manage symptoms. Read More

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January 2019
3 Reads

Significance of post-infectious Irritable Bowel Syndrome?

Authors:
Robin Spiller

Gastroenterology 2018 Nov 19. Epub 2018 Nov 19.

Professor of Gastroenterology, Co-Director Nottingham Digestive Diseases Biomedical Research Unit, Nottingham Digestive Diseases Centre, University of Nottingham, Queens Medical Centre. Electronic address:

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November 2018

Significance of Postinfectious Irritable Bowel Syndrome?

Authors:
Robin Spiller

Gastroenterology 2018 Nov 19. Epub 2018 Nov 19.

Department of Gastroenterology, Nottingham Digestive Diseases Biomedical Research Unit, Nottingham Digestive Diseases Centre, University of Nottingham, Queens Medical Centre, Nottingham, UK. Electronic address:

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November 2018

Hypomania Symptoms Across Psychiatric Disorders: Screening Use of the Hypomania Check-List 32 at Admission to an Outpatient Psychiatry Clinic.

Front Psychiatry 2018 7;9:527. Epub 2018 Nov 7.

Champalimaud Clinical Centre, Champalimaud Centre for the Unknown, Lisbon, Portugal.

Hypomania symptoms are best described as a continuum, ranging beyond Bipolar Spectrum Disorders (BSD). Other nosological entities, such as major depressive disorder, schizoaffective disorder, or borderline personality disorder, may also share symptoms with BSD, raising challenges for differential diagnosis. While the Hypomania Checklist-32 is one of the most widely used tools for screening hypomania, there is limited evidence describing its use in a real-world outpatient psychiatric clinical setting. Read More

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November 2018
4 Reads

Necrotizing Autoimmune myopathy: A case report on statin induced rhabdomyolysis requiring immunosuppressive therapy.

Drug Discov Ther 2018 ;12(5):315-317

Department of Internal Medicine, Creighton University School of Medicine.

Statins can cause a wide spectrum of muscular adverse effects ranging from asymptomatic elevation of Creatine Kinase (CK), myalgia and exercise intolerance to rhabdomyolysis. Most of these effects generally resolve on stopping the medication. However, statins can be associated with a unique autoimmune myopathy wherein symptoms persist or even progress after statin discontinuation and require immunosuppressive therapy. Read More

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January 2018
7 Reads

Clinical validation of the '7x7' questionnaire for patients with functional gastrointestinal disorders.

J Gastroenterol Hepatol 2018 Nov 21. Epub 2018 Nov 21.

V.H.Vasilenko Clinic of internal diseases, Propedeutics, Gastroenterology and Hepatology, Sechenov University, Moscow, Russian Federation.

Background And Aim: physicians use different scales and questionnaires to assess the severity of clinical symptoms in patients with functional gastrointestinal disorders. The current study aimed to validate the '7x7' questionnaire for assessment of severity of the symptoms as a tool for the efficacy of treatment of functional gastrointestinal disorders, using the Clinical Global Impressions scale as the reference standard.

Methods: fifty inpatients aged from 18 to 64 with a confirmed diagnosis of irritable bowel syndrome (26 patients, 52%), functional dyspepsia (15 patients, 30%) or both (9 patients, 18%) were prospectively enrolled in the study. Read More

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November 2018
2 Reads

Impact of Cultivation Method and Cultivar Selection on Soluble Carbohydrates and Pungent Principles in Onions ( Allium cepa L.).

J Agric Food Chem 2018 Nov 21. Epub 2018 Nov 21.

Institute of Food Science and Biotechnology, Chair of Plant Foodstuff Technology and Analysis , University of Hohenheim , Garbenstrasse 25 , D-70599 Stuttgart , Germany.

The composition of soluble carbohydrates such as fructooligosaccharides (FOS) in onions ( Allium cepa L.) plays a role regarding their digestibility, long-term storability, and processability. Qualitative and quantitative profiles of soluble carbohydrates were determined in 23 different onion samples comprising 20 cultivars grown at two different locations in 2014 and 2015. Read More

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November 2018
7 Reads

Probiotics in irritable bowel syndrome: Where are we?

Neurogastroenterol Motil 2018 Dec;30(12):e13513

Digestive System Research Unit, Departments of Gastroenterology, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona (Departamento de Medicina) and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Barcelona, Spain.

We have only recently begun to understand how alterations of the intestinal microbial ecosystem lead to the disruption of host-microbial interactions and are associated with diseases, including functional gastrointestinal disorders such as irritable bowel syndrome (IBS). Although we are still far from understanding the human microbiome, gut microbiota is already a therapeutic target. Probiotics are live microorganisms that, when administered in adequate amounts, confer a health benefit to the host and may represent a therapeutic option for diseases characterized by dysbiosis such as IBS. Read More

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December 2018
6 Reads

The Experience Sampling Method-Evaluation of treatment effect of escitalopram in IBS with comorbid panic disorder.

Neurogastroenterol Motil 2018 Nov 20:e13515. Epub 2018 Nov 20.

Division of Gastroenterology-Hepatology, Department of Internal Medicine, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center, Maastricht, The Netherlands.

Background: Confirming treatment response in clinical trials for irritable bowel syndrome (IBS) is challenging, due to the lack of biomarkers and limitations of the currently available symptom assessment tools. The Experience Sampling Method (ESM) might overcome these limitations by collecting digital assessments randomly and repeatedly during daily life. This study evaluated differences in change in abdominal pain between real-time (ie, ESM) and retrospective (ie, Gastrointestinal Symptom Rating Scale [GSRS] and an end-of-day symptom diary) measurements, using data of an RCT on escitalopram vs placebo in patients with IBS and comorbid panic disorder. Read More

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November 2018
4 Reads

Intestinal Microbiome in Irritable Bowel Syndrome before and after Gut-Directed Hypnotherapy.

Int J Mol Sci 2018 Nov 16;19(11). Epub 2018 Nov 16.

Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, 1090 Wien, Austria.

Irritable bowel syndrome (IBS) is a disorder with brain-gut-microbiome alterations. Gut-directed hypnotherapy (GHT) has been shown to improve quality of life and symptoms in IBS. This therapy targets psychological coping, central nervous processing and brain-gut interaction. Read More

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November 2018
3 Reads

The Contributions of Internal Intussusception, Irritable Bowel Syndrome, and Pelvic Floor Dyssynergia to Obstructed Defecation Syndrome.

Dis Colon Rectum 2019 Jan;62(1):56-62

Colorectal Surgery Center, Department of General and Gastrointestinal Surgery, Massachusetts General Hospital, Boston, Massachusetts.

Background: Recently, there has been a trend toward surgical management of internal intussusception despite an unclear correlation with constipation symptoms.

Objective: This study characterizes constipation in patients with obstructed defecation syndrome and identifies whether internal intussusception or other diagnoses such as irritable bowel syndrome may be contributing to symptoms.

Design: Patients evaluated for obstructed defecation at a pelvic floor disorder center were studied from a prospectively maintained database. Read More

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January 2019
1 Read

The temporal relationship of daily life stress, emotions, and bowel symptoms in irritable bowel syndrome-Diarrhea subtype: A smartphone-based experience sampling study.

Neurogastroenterol Motil 2018 Nov 18:e13514. Epub 2018 Nov 18.

Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong.

Background: The current study aimed to model the moment-to-moment relationship between daily life stress, emotions, and bowel symptoms among patients with irritable bowel syndrome-diarrhea subtype (IBS-D) in the flow of daily life using a smartphone-based experience sampling method (ESM).

Methods: Patients with IBS-D (N = 27) and healthy controls (HC; N = 30) completed ESM ratings of their real-time daily life stress, which was defined as subjective stress related to daily activities, both positive and negative emotions, as well as bowel symptoms eight times a day for 14 consecutive days, following a baseline interview measuring bowel and mood symptoms. Moment-to-moment association between ESM variables was tested within and between groups using multilevel regression modeling. Read More

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November 2018
5 Reads

Diagnosis and treatment of chronic abdominal pain 5 years after Roux-en-Y gastric bypass.

Surg Obes Relat Dis 2018 Oct 14;14(10):1544-1551. Epub 2018 Jun 14.

Department of Endocrinology, Morbid Obesity and Preventive Medicine, Oslo University Hospital, Oslo, Norway; Department of Pain Management and Research, Oslo University Hospital, Oslo, Norway.

Background: Knowledge of optimal diagnostic workup, etiology, and response to treatment of chronic abdominal pain after Roux-en-Y gastric bypass (RYGB) is limited.

Objective: To define the etiology of chronic abdominal pain presenting at the 5-year follow-up after RYGB and to evaluate response to treatment.

Setting: Oslo University Hospital (tertiary referral center for obesity surgery). Read More

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October 2018
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IBS clinical management in Italy: The AIGO survey.

Dig Liver Dis 2018 Oct 22. Epub 2018 Oct 22.

Gastroenterology Unit, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.

Background: Irritable bowel syndrome (IBS) is the most frequent functional gastrointestinal disorder, both in primary and secondary care.

Aims: (1) To describe diagnostic tools and treatments suggested to IBS patients by Italian gastroenterologists; (2) To evaluate patients' quality of life and psychological involvement and the relationship of these factors with symptom severity.

Methods: Twenty-six gastroenterologists recorded the demographic and clinical data of 677 IBS patients. Read More

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October 2018
8 Reads