21,473 results match your criteria Iron Deficiency Anemia

Fermented goat milk modulates immune response during iron deficiency anemia recovery.

J Sci Food Agric 2021 Jul 30. Epub 2021 Jul 30.

Department of Physiology, University of Granada, Granada, Spain.

Background: Iron deficiency and iron overload can affect the normal functioning of the innate and adaptive immune responses, and fermented milk products may enhance immune functions, but little is known about the effect of fermented milks on modulation of immune response during iron-deficiency anemia and recovery with normal or high dietary iron intake. 80 male Wistar rats were divided randomly assigned to a control group fed the standard diet and to an anemic group fed a diet deficit in iron. Control and anemic groups were fed for 30 days with diets based on a fermented goat's or cow's milk product, with iron normal content or iron overload. Read More

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Clinical Image: Magnetic Resonance Imaging Appearance of Scurvy.

Arthritis Rheumatol 2021 Jul 30. Epub 2021 Jul 30.

B. Shine Rheumatology Institute, Rambam Health Care Campus, Haifa, Israel.

A 40-year-old previously healthy woman presented to the Rheumatology department with suspected arthritis because of bilateral lower limb pain, swelling, and difficulty walking for the last six months. Physical examination revealed multiple subcutaneous hematomas, gingival hyperplasia, bilateral knee effusion, lower extremities muscle weakness, and right hip joint movement limitation. The laboratory tests were remarkable only for iron and folate deficiency normocytic anemia (Hemoglobin 9 mg/dl). Read More

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Erythropoietin-Resistant Anemia Secondary to Zinc-Induced Hypocupremia in a Hemodialysis Patient.

Case Rep Nephrol Dial 2021 May-Aug;11(2):167-175. Epub 2021 Jul 1.

East Georgia Kidney and Hypertension, Augusta, Georgia, USA.

Excessive intake of zinc is a known but often forgotten cause of copper deficiency, and its consequences in the context of end-stage renal disease (ESRD) are not widely discussed. Zinc-induced copper deficiency (ZICD) can result in erythropoietin (EPO)-resistant anemia and may not be considered as a possible etiology when conducting the work-up. We present a case wherein an ESRD patient had been receiving excess zinc for several months and subsequently experienced EPO-resistant anemia. Read More

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Graves' disease patients with iron deficiency anemia: serologic evidence of co-existent autoimmune gastritis.

Am J Blood Res 2021 15;11(3):238-247. Epub 2021 Jun 15.

Division of Endocrinology and Metabolism, Division of Hematology and Oncology, Harbor-UCLA Medical Center and The David Geffen School of Medicine at UCLA Los Angeles, CA, USA.

Background: Graves' disease (GD) has been associated with iron deficiency anemia (IDA). Atrophic gastritis leads to IDA and has been associated with autoimmune thyroid disease. This study prospectively determined the prevalence of atrophic gastritis markers and the relationship between these markers and markers of IDA in GD subjects. Read More

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Thrombocytopenia secondary to iron deficiency anemia responding to iron therapy.

Clin Case Rep 2021 Jul 18;9(7). Epub 2021 Jun 18.

Hamad Medical Corporation Doha Qatar.

A broad spectrum of diseases can cause anemia and thrombocytopenia. Some of these diseases are a hematological emergency; others are benign diseases, so early and accurate diagnosis is crucial in managing such patients. Usually, IDA is associated with thrombocytosis or normal platelets; however, in rare cases, IDA can be associated with thrombocytopenia; even though, thrombocytopenia that occurs with IDA responds to iron therapy. Read More

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Implementation of European Society of Gastrointestinal Endoscopy (ESGE) recommendations for small-bowel capsule endoscopy into clinical practice: Results of an official ESGE survey.

Endoscopy 2021 Jul 28. Epub 2021 Jul 28.

Pomeranian Medical University, Department of Social Medicine and Public Health, Faculty of Health Science, Szczecin, Poland.

Background:  We aimed to document international practices in small-bowel capsule endoscopy (SBCE), measuring adherence to European Society of Gastrointestinal Endoscopy (ESGE) technical and clinical recommendations.

Methods:  Participants reached through the ESGE contact list completed a 52-item web-based survey.

Results:  217 responded from 47 countries (176 and 41, respectively, from countries with or without a national society affiliated to ESGE). Read More

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Iron Deficiency Anemia-Induced Cardiomyopathy With Congestive Heart Failure: Reversible Cardiac Dysfunction Assessed by Multi-Imaging Modalities.

JACC Case Rep 2020 Sep 15;2(11):1806-1811. Epub 2020 Sep 15.

Department of Cardiology, Hokkaido Ohno Memorial Hospital, Sapporo, Japan.

Iron deficiency anemia (IDA) can cause left ventricular (LV) dysfunction, causing heart failure. A 48-year-old woman with severe IDA developed congestive heart failure that was properly diagnosed, managed, and followed with multiple imaging modalities to explore potential mechanisms, highlighting the reversibility of LV function in unique cardiomyopathy. (). Read More

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September 2020

Celiac disease in children: A review of the literature.

Yasin Sahin

World J Clin Pediatr 2021 Jul 9;10(4):53-71. Epub 2021 Jul 9.

Pediatric Gastroenterology-Hepatology and Nutrition, Medical Park Gaziantep Hospital, Gaziantep 27560, Turkey.

Celiac disease is an immune-mediated systemic disease triggered by intake of gluten in genetically susceptible individuals. The prevalence of celiac disease in the general population is estimated to be 1% in the world. Its prevalence differs depending on geographical and ethnic variations. Read More

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GWAS of serum ALT and AST reveals an association of SLC30A10 Thr95Ile with hypermanganesemia symptoms.

Nat Commun 2021 07 27;12(1):4571. Epub 2021 Jul 27.

Alnylam Pharmaceuticals, Cambridge, MA, USA.

Understanding mechanisms of hepatocellular damage may lead to new treatments for liver disease, and genome-wide association studies (GWAS) of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) serum activities have proven useful for investigating liver biology. Here we report 100 loci associating with both enzymes, using GWAS across 411,048 subjects in the UK Biobank. The rare missense variant SLC30A10 Thr95Ile (rs188273166) associates with the largest elevation of both enzymes, and this association replicates in the DiscovEHR study. Read More

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Iron deficiency and iron deficiency anemia in pregnancy.

CMAJ 2021 Jul;193(29):E1137-E1138

Department of Obstetrics & Gynaecology (Malinowski, Murji), Sinai Health System; University of Toronto (Malinowski, Murji), Toronto, Ont.

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Efficacy of an injectable toltrazuril - gleptoferron (Forceris®) to control coccidiosis (Cystoisospora suis) in comparison with iron supplemented piglets without anticoccidial treatment.

Vet Parasitol 2019 29;276S:100002. Epub 2019 Jan 29.

Albrecht - Daniel - Thaer - Institute for Agricultural Sciences e.V. at University of Leipzig, An den Tierkliniken 29, 04103 Leipzig, Germany; Institute of Parasitology, Faculty of Veterinary Medicine, University of Leipzig, An den Tierkliniken 35, 04103 Leipzig, Germany.

The efficacy and safety of an injectable combination product containing toltrazuril and gleptoferron (Forceris® - CEVA) for the control of coccidiosis due to Cystoisospora suis was investigated in neonatal piglets. The study was carried out on five European commercial pig farms in France, Germany and Spain and 122 litters consisting of 1508 piglets were selected and randomly allocated to one of two treatment groups. The first group received a single intramuscular injection per piglet of the test product, containing 45 mg toltrazuril and 200 mg iron and this was compared with a control group, which was administered a single intramuscular treatment of iron at 200 mg per piglet only. Read More

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January 2019

Potential effective treatment of shortening continuous erythropoietin receptor activator treatment interval combined with iron supplementation in hemodialysis patients.

J Pharmacol Sci 2021 Sep 12;147(1):118-125. Epub 2021 Jun 12.

Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, 236-0004, Japan.

Our previous randomized controlled trial comparing the total dose of weekly versus biweekly continuous erythropoietin receptor activator (CERA) therapy to maintain optimal hemoglobin (Hb) levels showed no significant differences between the two therapies. This post-hoc analysis assessed whether the total dose of weekly versus biweekly CERA therapy to maintain Hb levels among HD patients differed among groups with or without iron supplementation. Of 107 patients, 40 received intravenous iron supplementation due to iron deficiency (iron group) and 67 did not (non-iron group). Read More

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September 2021

Iron Depletion, Iron Deficiency, and Iron Deficiency Anaemia Among Children Under 5 Years Old in Kilimanjaro, Northern Tanzania: A Hospital-Based Cross-Sectional Study.

East Afr Health Res J 2019 30;3(1):42-47. Epub 2019 Jul 30.

Department of Paediatrics and Child Health, Kilimanjaro Christian Medical Centre, Moshi, Tanzania.

Background: Iron depletion results from reduced iron stores, and it is an early stage of disease progression before iron deficiency, which leads to iron deficiency anaemia (IDA). IDA is associated with delayed infant growth and development, diminished cognitive function, poor academic performance, decreased exercise tolerance, and impaired immune function. This study aimed to determine the prevalence of iron depletion and IDA and factors associated with low ferritin levels among children under 5-years-old receiving care at Kilimanjaro Christian Medical Centre (KCMC) in Moshi, Tanzania. Read More

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Basal and resistance exercise-induced increase in protein synthesis is impaired in skeletal muscle of iron-deficient rats.

Nutrition 2021 Jun 12;91-92:111389. Epub 2021 Jun 12.

Laboratory of Exercise Nutrition, Department of Nutrition, University of Shiga Prefecture, Japan.

Objectives: We aimed to investigate the effect of iron deficiency on basal- and contraction-induced increases in muscle protein synthesis.

Methods: Four-wk-old male Sprague-Dawley rats were divided into three groups. The rats in two of the three groups had free access to a control diet (AD) or iron-deficient diet (ID) for 4 wk. Read More

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Preoperative hemogram as a predictive factor for iron deficit and/or transfusion in patients scheduled for arthroplasty.

Rev Esp Anestesiol Reanim 2021 Jul 21. Epub 2021 Jul 21.

Banco de Sangre y Tejidos de Navarra, Servicio Navarro de Salud, Osasunbidea, Pamplona, España; Grupo Español de Rehabilitación Multimodal (GERM), Instituto Aragonés de Ciencias de la Salud, Zaragoza, España; PBM Group, Hospital La Paz Institute for Health Research (IdiPAZ), Madrid, España. Electronic address:

Introduction: Anemia and iron deficiency predispose to an increased risk of transfusion with a consequent increase in morbidity and mortality. The study analyzes whether blood cell count parameters in addition to detecting anemia can predict iron deficiency and/or transfusional risk in patients undergoing mostly to scheduled primary hip and knee arthroplasty.

Objective: To analyze how blood cell count parameters predict iron deficiency and/or transfusional risk in patients undergoing programmed arthroplasty. Read More

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Preoperative iron status is a prognosis factor for stage II and III colorectal cancer.

Int J Clin Oncol 2021 Jul 23. Epub 2021 Jul 23.

Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto, 860-8556, Japan.

Background: Iron deficiency anemia is represented in colorectal cancer (CRC) patients. Iron surplus load to increase non-transferrin bound iron (NTBI), and NTBI promotes cancer progression and influences microbiota. This study investigated whether preoperative serum iron status was associated with prognosis after CRC resection. Read More

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Micronutrients deficiences in patients after bariatric surgery.

Eur J Nutr 2021 Jul 23. Epub 2021 Jul 23.

Faculty of Medicine, Ovidius University of Constanta, Constanta, Romania.

Bariatric surgery is an effective option for managing obesity and has gained general acceptance among patients in recent years. Generally, despite the high caloric intake, a bad nutritional habit of obese people results in the deficiency of several vitamins, minerals, and trace elements essential for body metabolism and normal physiological processes. Additionally, the current bariatric surgical approaches such as sleeve gastrectomy (SG), Roux-en-Y-gastric bypass (RYGB), laparoscopic adjustable gastric banding (LAGB), and jejunoileal bypass (JIB) can cause or exacerbate these deficiencies. Read More

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Anemia in Pregnancy: ACOG Practice Bulletin, Number 233.


Obstet Gynecol 2021 08;138(2):e55-e64

Anemia, the most common hematologic abnormality, is a reduction in the concentration of erythrocytes or hemoglobin in blood. The two most common causes of anemia in pregnancy and the puerperium are iron deficiency and acute blood loss. Iron requirements increase during pregnancy, and a failure to maintain sufficient levels of iron may result in adverse maternal-fetal consequences. Read More

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Anemia in Pregnancy: ACOG Practice Bulletin Summary, Number 233.


Obstet Gynecol 2021 Aug;138(2):317-319

Anemia, the most common hematologic abnormality, is a reduction in the concentration of erythrocytes or hemoglobin in blood. The two most common causes of anemia in pregnancy and the puerperium are iron deficiency and acute blood loss. Iron requirements increase during pregnancy, and a failure to maintain sufficient levels of iron may result in adverse maternal-fetal consequences. Read More

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Ferric Citrate Dosing in Iron Deficiency Anemia in Nondialysis-Dependent Chronic Kidney Disease.

Am J Nephrol 2021 Jul 22:1-10. Epub 2021 Jul 22.

Akebia Therapeutics, Inc., Cambridge, Massachusetts, USA.

Introduction: Ferric citrate (FC) is indicated as an oral iron replacement for iron deficiency anemia in adult patients with chronic kidney disease (CKD) not on dialysis. The recommended starting dose is one 1-g tablet three times daily (TID). This study investigated long-term efficacy and safety of different FC dosing regimens for treating anemia in nondialysis-dependent CKD (NDD-CKD). Read More

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Оxidative stress and endogenous intoxication in cancer patients.

Klin Lab Diagn 2021 Jul;66(7):401-406

Federal State Budgetary Institution "National Medical Research Center of Oncology N.N. Blokhin", under the Ministry of Health of the Russian Federation.

In the blood serum of 93 patients with various localities of the malignant process, the content of nitric oxide (NO), indicators of lipid peroxidation (POL): superoxide dismutase (SOD), malondialdehyde (MDA) and glutathione in red blood cells were determined. 9 patients with ovarian cancer were examined during chemotherapy (6 courses), 40 patients with colon cancer, previously operated, were with malignant liver damage. In 39 patients with anemia, NO indicators were compared with the level of interleukin 6 (IL-6) and hepcidin-25 (GP-25). Read More

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Pazopanib for severe bleeding and transfusion-dependent anemia in hereditary hemorrhagic telangiectasia.

Angiogenesis 2021 Jul 22. Epub 2021 Jul 22.

Division of Hematology, Massachusetts General Hospital, Zero Emerson Pl Suite 118, Office 112, Boston, MA, 02114, USA.

Hereditary hemorrhagic telangiectasia (HHT) is a rare angiogenic disorder causing chronic gastrointestinal bleeding, epistaxis, and severe anemia. Pazopanib is an oral multi-kinase angiogenesis inhibitor with promise to treat bleeding in HHT. We analyzed outcomes of HHT patients with the most severe bleeding causing RBC transfusion dependence treated on a predefined institutional pazopanib treatment pathway (with data collected retrospectively). Read More

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Chronic Iron Deficiency Anaemia Caused by Blue Rubber Bleb Syndrome (BRBS).

J Pediatr Gastroenterol Nutr 2021 Jul 20. Epub 2021 Jul 20.

University of Liverpool Alder Hey Children's NHS Foundation Trust, Liverpool, L12 2AP Glan Clwyd Hospital, Rhyl, Denbighshire, Wales, LL18 5UJ.

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Effect of cooking food in iron-containing cookware on increase in blood hemoglobin level and iron content of the food: A systematic review.

Nepal J Epidemiol 2021 Jun 30;11(2):994-1005. Epub 2021 Jun 30.

Centre for Community Medicine, All India Institute of Medical Sciences, New Delhi, India.

In developing countries there is a need for simple and cost-effective strategies to reduce the prevalence of iron deficiency anemia. The objective of the current systematic review is to summarize how cooking food in iron pots or iron ingots can increase the blood hemoglobin level and iron content of the food. Literature search was conducted using databases namely PubMed, Google Scholar, Medline-Ovid, IndMed, Cochrane library, World Health Organization bulletin and by cross-referencing articles. Read More

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Laboratory approach to investigation of anemia in pregnancy.

Int J Lab Hematol 2021 Jul;43 Suppl 1:65-70

Department of Pathology, University of Utah Health and ARUP Laboratories, Salt Lake City, UT, USA.

Anemia is a global health problem in all age groups. According to World Health Organization (WHO), approximately 40% of pregnant women are anemic. Iron deficiency anemia (IDA) due to nutritional deficiency is the most common cause. Read More

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A simplified diagnostic pathway for the differential diagnosis of iron deficiency anaemia and anaemia of chronic disease.

Int J Lab Hematol 2021 Jul 20. Epub 2021 Jul 20.

Centre for Bioscience, Manchester Metropolitan University, Manchester, UK.

Introduction: Iron deficiency anaemia (IDA) and anaemia of chronic disease (ACD) are common causes of anaemia with similar clinical and laboratory features. IDA is caused by low iron stores while ACD is due to iron-restricted erythropoiesis occurring in inflammatory states. Differential diagnosis requires analysis of multiple biochemical and haematological parameters. Read More

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Impact of IgG response to malaria-specific antigens and immunity against malaria in pre-school children in Ghana. A cluster randomized, placebo-controlled trial.

PLoS One 2021 20;16(7):e0253544. Epub 2021 Jul 20.

Kintampo Health Research Centre, Kintampo-North, Ghana.

Background: Iron fortification and micronutrient initiatives, specifically, vitamin A, and zinc supplementation are the most cost-effective developmental strategies against malnutrition and health emergencies in pre-school children. Iron-deficiency among pre-school children have been documented, however, studies evaluating the impact of immunoglobulin G (IgG) isotype responses among iron-fortified pre-school children in malaria endemic communities has not been assessed. We evaluated the impact of iron fortification on the IgG responses to GLURP R0, GLURP R2 and MSP3 FVO malaria-specific antigens among pre-school children in malaria endemic areas. Read More

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Knowledge Gaps in Understanding the Etiology of Anemia in Indonesian Adolescents.

Food Nutr Bull 2021 06;42(1_suppl):S39-S58

4508Wageningen University & Research, Wageningen, the Netherlands.

Background: Anemia is a public health problem among adolescents in Indonesia. Strategies to prevent or treat anemia should be tailored to local conditions, taking into account its specific etiology and prevalence in a given setting and population group.

Objective: This review aims to (1) identify and synthesize the current knowledge on the etiology of anemia among adolescents in Indonesia, (2) reveal knowledge gaps in this area, and (3) suggest directions for future research and programmatic work. Read More

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Managing Anemia across the Stages of Kidney Disease in Those Hyporesponsive to Erythropoiesis-Stimulating Agents.

Matthew R Weir

Am J Nephrol 2021 Jul 19;52(6):450-466. Epub 2021 Jul 19.

Division of Nephrology, University of Maryland Medical Center, Baltimore, Maryland, USA.

Background: Patients with CKD frequently have anemia that results from iron-restricted erythropoiesis and inflammation. Anemia of CKD is currently managed with iron supplements and erythropoiesis-stimulating agents (ESAs) to promote erythropoiesis and with RBC transfusion in severe cases. Hyporesponse to ESAs, or the need for larger than usual doses to attain a given hemoglobin (Hb) level, is associated with increased morbidity and mortality and presents a pressing clinical challenge, particularly for patients on dialysis. Read More

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