20,358 results match your criteria Iron Deficiency Anemia


Young adult outcomes associated with lower cognitive functioning in childhood related to iron-fortified formula in infancy.

Nutr Neurosci 2020 Aug 11:1-10. Epub 2020 Aug 11.

Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA.

This study examined how the lower cognitive skills in children who consumed iron-fortified formula in infancy relate to outcomes in young adulthood. Participants were 443 Chilean young adults ( age = 21.2y, 55% female) who took part in a randomized controlled iron-deficiency anemia preventive trial during infancy (6-12 m). Read More

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http://dx.doi.org/10.1080/1028415X.2020.1804099DOI Listing

The Impact of the Ferric Carboxymaltose on Hemoglobin and Ferritin Levels.

Clin Lab 2020 Aug;66(8)

Background: Anemia is a frequent disorder worldwide. Iron deficiency anemia (IDA) is the most common form of anemia. Although oral iron is the first choice for treatment, the efficacy of oral iron preparations may be limited. Read More

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http://dx.doi.org/10.7754/Clin.Lab.2020.191030DOI Listing

Portuguese Consensus on Diagnosis, Treatment, and Management of Anemia in Pediatric Inflammatory Bowel Disease.

GE Port J Gastroenterol 2020 Jul 10;27(4):244-254. Epub 2020 Jan 10.

Pediatric Gastroenterology, Hepatology and Nutrition Unit and Clinical Academic Center 2CA-Braga, Hospital de Braga, Braga, Portugal.

Anemia is a common extraintestinal manifestation of inflammatory bowel disease (IBD), both in pediatric and in adult patients. Iron deficiency is the main cause of anemia in patients with IBD. Anemia is a clinically relevant comorbidity, with impact on patients' quality of life and it should be timely diagnosed and adequately treated. Read More

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http://dx.doi.org/10.1159/000505071DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7383296PMC

Oral Iron Therapy-Induced Neutropenia in Patient with Iron Deficiency Anemia.

Case Rep Oncol 2020 May-Aug;13(2):721-724. Epub 2020 Jun 24.

Department of Medical Oncology, National Center for Cancer Care and Research, Doha, Qatar.

Iron deficiency anemia is common and worldwide distributed, particularly among females; however, it can also occur among males. Iron deficiency anemia is commonly associated with thrombocytosis; little is known about the effect of iron therapy (oral or intravenous) on other hematological parameters. We report a 29-year-old male patient with iron deficiency anemia, who received oral iron replacement therapy and developed neutropenia which recovered spontaneously 1 month later. Read More

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http://dx.doi.org/10.1159/000507730DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7383194PMC

Unrecognized Anemia After Whipple - Should We Learn from Gastric Bypass?

Expert Rev Gastroenterol Hepatol 2020 Aug 8. Epub 2020 Aug 8.

Assistant Chair of Clinical Sciences, Head of Surgery, TCU and UNTHSC School of Medicine, Director of HPB/UGI fellowship and Gastrointestinal Services.

Introduction: Several pathophysiologic changes after the Whipple procedure have been well described, but anemia has not. Post-surgical changes can impede micronutrient absorption. We hypothesize that patients post-pancreatoduodenectomy suffer from iron deficiency anemia. Read More

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http://dx.doi.org/10.1080/17474124.2020.1808459DOI Listing

A wandering spleen, splenomegaly, hypersplenism, and iron deficiency anaemia.

Lancet 2020 08;396(10248):412

Hôpital européen Georges-Pompidou, Médecine Interne, Assistance Publique, Hôpitaux de Paris, Paris, France.

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http://dx.doi.org/10.1016/S0140-6736(20)31552-XDOI Listing

VITAMIN D STATUS IS ASSOCIATED WITH HEPCIDIN AND HEMOGLOBIN CONCENTRATIONS IN PATIENTS WITH SEVERE TRAUMATIC INJURY.

J Trauma Acute Care Surg 2020 Jul 28. Epub 2020 Jul 28.

1 University of Florida Health, Department of Surgery and Sepsis and Critical Illness Research Center, Gainesville, Florida 2 University of Florida, Department of Orthopedic Surgery, Gainesville, Florida.

Background: Severe traumatic injury leads to persistent injury-associated anemia that is associated with hypercatecholaminemia, systemic inflammation, increased hepcidin and a functional iron deficiency. Vitamin D has been shown to reduce proinflammatory cytokines and hepcidin concentrations. This study aimed to investigate the association of vitamin D status with inflammation, iron biomarkers and anemia following blunt trauma. Read More

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http://dx.doi.org/10.1097/TA.0000000000002895DOI Listing

Screening for Iron Deficiency Anemia in Infants in a Thalassemia-endemic Region.

J Pediatr Hematol Oncol 2020 Aug 4. Epub 2020 Aug 4.

Department of Pediatrics, Faculty of Medicine, Chiang Mai University.

Screening for iron deficiency anemia (IDA) in infants is usually carried out by hemoglobin (Hb) level and mean corpuscular volume (MCV). A coinherited thalassemia carrier may confound the diagnosis of IDA. This study aimed to characterize the hematologic parameters in infants with IDA and in thalassemia carriers, and to study the use of red cell parameters in IDA screening in a thalassemia-endemic area. Read More

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http://dx.doi.org/10.1097/MPH.0000000000001893DOI Listing

Iron deficiency following bariatric surgery: a retrospective cohort study.

Blood Adv 2020 Aug;4(15):3639-3647

Department of Medicine and.

Iron deficiency is a common consequence of bariatric surgery and frequently leads to anemia. Our study reports the incidence and predictors of iron deficiency, iron deficiency anemia (IDA), and IV iron use after bariatric surgery. We conducted a retrospective study of all adult patients who underwent bariatric surgery from January to December 2012 at the regional bariatric surgery center in Hamilton, Ontario, Canada, and were followed for at least 6 months. Read More

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http://dx.doi.org/10.1182/bloodadvances.2020001880DOI Listing

Use of prokinetics and other quality factors in capsule endoscopy - old and new insights (Review).

Exp Ther Med 2020 Sep 29;20(3):2484-2488. Epub 2020 Jun 29.

Department of Gastroenterology, 'Carol Davila' Central Military Emergency University Hospital, 010825 Bucharest, Romania.

Despite the extensive recent development of different techniques for endoscopic evaluation for both diagnostic and therapeutic reasons, the small bowel remains quite difficult to visualize. Capsule endoscopy and device assisted enteroscopy are presently considered the best diagnostic tools for examination of small bowel disorders, assessing diverse pathologies such as obscure gastrointestinal bleeding, iron deficiency anemia, Crohn disease, small bowel tumors and polyposis syndromes. Like any other imagistic method, it has specific indications, and contraindications, and possibly it is more important to consider limitations. Read More

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http://dx.doi.org/10.3892/etm.2020.8960DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7401576PMC
September 2020

Effects of Iron Deficiency on Serum Metabolome, Hepatic Histology, and Function in Neonatal Piglets.

Animals (Basel) 2020 Aug 5;10(8). Epub 2020 Aug 5.

Hunan Provincial Key Laboratory of Animal Intestinal Function and Regulation, Hunan international joint Laboratory of Animal Intestinal Ecology and Health, College of Life Sciences, Hunan Normal University, Changsha 410081, Hunan, China.

Few studies focused on the effects of iron on characterizing alterations of metabolic processes in neonatal piglets. In the present study, 16 neonatal piglets were randomly assigned to two groups. In the first group piglets were given an intramuscularly injection of iron dextran at 150 mg as a positive control (CON) and the second group were not supplemented with iron as a negative control for iron deficiency (ID). Read More

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http://dx.doi.org/10.3390/ani10081353DOI Listing

[Characteristics of the metabolic status of children of the first year of life with protein-energy deficiency depending on the gestational age at birth.]

Klin Lab Diagn 2020 Jun;65(7):405-410

Samara State Medical University, 443099, Samara, Russia.

Comparative analysis of energy-plastic exchange indicators in mature and premature children of the first year of life in the development of protein-energy malnutrition (PEM) was carried out. Unidirectional changes are revealed, including an increase in creatinine, lactate and creatine phosphokinase activity levels, suggesting a n increasing muscle mass deficit against the background of glucose anaerobic oxidation activation. In preterm infants, glucose and triacylglicerine levels decrease, which reflects uncompensated insufficiency of energy substrates and, accordingly, ATP level. Read More

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http://dx.doi.org/10.18821/0869-2084-2020-65-7-405-410DOI Listing

Cerebral Venous Sinus Thrombosis Related to Iron-Deficiency Anemia.

Cureus 2020 Jun 29;12(6):e8917. Epub 2020 Jun 29.

Pediatrics, Oakland University William Beaumont School of Medicine, Royal Oak, USA.

Cerebral venous sinus thrombosis (CVST) is an uncommon diagnosis associated with life-threatening and long-term neurological consequences in children. It is characterized by non-specific symptoms, including fever, altered mental status and focal neurological deficits. Etiologic factors include infection, trauma, prothrombotic disorders and importantly, iron-deficiency anemia. Read More

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http://dx.doi.org/10.7759/cureus.8917DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7392185PMC

[Ring sideroblasts and iron metabolism].

Authors:
Tohru Fujiwara

Rinsho Ketsueki 2020 ;61(7):770-778

Department of Hematology and Rheumatology, Tohoku University Graduate School of Medicine.

Ring sideroblasts show abnormal mitochondrial iron accumulation, and their emergence in the bone marrow is a characteristic of sideroblastic anemias (SAs). SAs are a group of heterogeneous congenital and acquired disorders. Congenital SA is a rare disease caused by gene mutations involved in heme biosynthesis, iron-sulfur cluster biosynthesis, and mitochondrial protein synthesis. Read More

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http://dx.doi.org/10.11406/rinketsu.61.770DOI Listing
January 2020

[Iron dysregulation in chronic kidney disease].

Rinsho Ketsueki 2020 ;61(7):764-769

Department of Internal Medicine, Division of Kidney and Dialysis, Hyogo College of Medicine.

Anemia remains an important complication of patients with chronic kidney disease (CKD). Relative erythropoietin deficiency was assumed to be the main cause of anemia in CKD. In contrast, it is possible that iron dysregulation for erythropoiesis in CKD patients also affects not only anemia but also cardiovascular event or survival of these patients. Read More

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http://dx.doi.org/10.11406/rinketsu.61.764DOI Listing
January 2020

Iron Deficiency Anemia at Time of Vaccination Predicts Decreased Vaccine Response and Iron Supplementation at Time of Vaccination Increases Humoral Vaccine Response: A Birth Cohort Study and a Randomized Trial Follow-Up Study in Kenyan Infants.

Front Immunol 2020 13;11:1313. Epub 2020 Jul 13.

Department of Health Sciences and Technology, Institute of Food, Nutrition and Health, Laboratory of Human Nutrition, ETH Zürich, Zurich, Switzerland.

Iron deficiency may impair adaptive immunity and is common among African infants at time of vaccination. Whether iron deficiency impairs vaccine response and whether iron supplementation improves humoral vaccine response is uncertain. We performed two studies in southern coastal Kenya. Read More

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http://dx.doi.org/10.3389/fimmu.2020.01313DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7369313PMC

Observations from a peculiar case of volatile substance dependence-A case report.

J Addict Dis 2020 Aug 4:1-4. Epub 2020 Aug 4.

Associate Professor, Department of Psychiatry, Baroda Medical College, Baroda, India.

Volatile substance dependence is a relatively rare form of substance use disorders. It is predominantly noted in the adolescent age group. Higher prevalence is also seen in individuals from the lower socio-economic strata. Read More

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http://dx.doi.org/10.1080/10550887.2020.1801131DOI Listing

Iron Metabolism in Obesity and Metabolic Syndrome.

Int J Mol Sci 2020 Aug 1;21(15). Epub 2020 Aug 1.

Inflammation, Nutrition, Metabolism and Oxidative Stress Study Group (INMOX), Biomedical Research and Innovation Institute of Cádiz (INiBICA), Research Unit, Puerta del Mar University Hospital, 11009 Cádiz, Spain.

Obesity is an excessive adipose tissue accumulation that may have detrimental effects on health. Particularly, childhood obesity has become one of the main public health problems in the 21st century, since its prevalence has widely increased in recent years. Childhood obesity is intimately related to the development of several comorbidities such as nonalcoholic fatty liver disease, dyslipidemia, type 2 diabetes mellitus, non-congenital cardiovascular disease, chronic inflammation and anemia, among others. Read More

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http://dx.doi.org/10.3390/ijms21155529DOI Listing

Trying to Solve the Puzzle of the Interaction of Ascorbic Acid and Iron: Redox, Chelation and Therapeutic Implications.

Medicines (Basel) 2020 Jul 30;7(8). Epub 2020 Jul 30.

Institute of Chemical Kinetics and Combustion, 630090 Novosibirsk, Russia.

Iron and ascorbic acid (vitamin C) are essential nutrients for the normal growth and development of humans, and their deficiency can result in serious diseases. Their interaction is of nutritional, physiological, pharmacological and toxicological interest, with major implications in health and disease. Millions of people are using pharmaceutical and nutraceutical preparations of these two nutrients, including ferrous ascorbate for the treatment of iron deficiency anaemia and ascorbate combination with deferoxamine for increasing iron excretion in iron overload. Read More

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http://dx.doi.org/10.3390/medicines7080045DOI Listing

Prevalence and Predictive Value of Anemia and Dysregulated Iron Homeostasis in Patients with COVID-19 Infection.

J Clin Med 2020 Jul 29;9(8). Epub 2020 Jul 29.

Department of Internal Medicine II, Infectious Disease, Immunology, Rheumatology, Medical University of Innsbruck, 6020 Innsbruck, Austria.

Infections with SARS-CoV-2 can result in severe clinical manifestations. As such patients present with systemic inflammation, we studied the prevalence and predictive value of anemia of inflammation (AI) or functional iron deficiency (FID), originating from immune-mediated alterations of iron homeostasis. Within this retrospective analysis of 259 hospitalized patients with COVID-19, we found that, upon admission, 24. Read More

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http://dx.doi.org/10.3390/jcm9082429DOI Listing

In vitro bioaccessibility and bioavailability of iron from fenugreek, baobab and moringa.

Food Chem 2020 Jul 28;335:127671. Epub 2020 Jul 28.

Department of Nutritional Sciences, School of Life Course Sciences, King's College London, Franklin-Wilkins-Building, 150 Stamford Street, London SE1 9NH, UK. Electronic address:

Iron deficiency anaemia (IDA) is a common nutritional disorder worldwide. Sustainable food-based approaches are being advocated to use high and bioavailable dietary iron sources to prevent iron deficiency. The study investigated the bioaccessibility and bioavailability of iron from some plant products. Read More

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http://dx.doi.org/10.1016/j.foodchem.2020.127671DOI Listing

A pilot study on secondary anemia in "frailty" patients treated with Ferric Sodium EDTA in combination with vitamin C, folic acid, copper gluconate, zinc gluconate and selenomethionine: safety of treatment explored by HRV non-linear analysis as predictive factor of cardiovascular tolerability.

Eur Rev Med Pharmacol Sci 2020 Jul;24(14):7776-7783

Alfredo Fiorini Hospital, Terracina, (Latina), Italy.

Objective: Iron deficiency anemia (IDA) in patients with heart disease is correlated with decreased exercise capacity and poor health-related quality of life, and predicts worse cardiovascular outcomes, especially for elderly patients. IDA can worsen cardiac function that can be monitored with Heart Rate Variability (HRV) analysis, providing important information about cardiac health. In a recent study we explored the effect and the tolerability of the administration of Ferric Sodium EDTA in combination with vitamin C, folic acid, copper gluconate, zinc gluconate and selenomethionine (Ferachel Forte®) in "frailty" patients with secondary anemia and low kidney failure, by analysing the HRV frequency domain. Read More

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http://dx.doi.org/10.26355/eurrev_202007_22280DOI Listing

Adjusting iron and vitamin A status in settings of inflammation: a sensitivity analysis of the Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA) approach.

Am J Clin Nutr 2019 Aug;112(Supplement_1):458S-467S

Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA.

Background: Accurate assessment of iron and vitamin A status is needed to inform public health decisions, but most population-level iron and vitamin A biomarkers are independently influenced by inflammation.

Objectives: We aimed to assess the reproducibility of the Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA) regression approach to adjust iron [ferritin, soluble transferrin receptor (sTfR)] and vitamin A [retinol-binding protein (RBP), retinol] biomarkers for inflammation (α-1-acid glycoprotein and C-reactive protein).

Methods: We conducted a sensitivity analysis comparing unadjusted and adjusted estimates of iron and vitamin A deficiency using the internal-survey regression approach from BRINDA phase 1 (16 surveys in children, 10 surveys in women) and 13 additional surveys for children and women (BRINDA phase 2). Read More

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http://dx.doi.org/10.1093/ajcn/nqaa141DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7396268PMC

Gastroenterologist-Lead Management of Iron Deficiency Anemia in Inflammatory Bowel Disease Is Effective, Safe, and May Increase Quality of Life.

Crohns Colitis 360 2020 Jul 24;2(3):otaa051. Epub 2020 Jun 24.

Division of Gastroenterology, Hepatology, and Nutrition, Department of Internal Medicine and Public Health, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

Background: The effectiveness and safety of gastroenterologist (GI)-lead treatment of iron deficiency anemia (IDA) in inflammatory bowel disease (IBD) have not been well-studied.

Methods: A retrospective chart review of patients with IBD, IDA, and evidence of treatment with iron at a tertiary IBD center was conducted.

Results: In 351 patients, hemoglobin and quality of life scores increased significantly after treatment with iron. Read More

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http://dx.doi.org/10.1093/crocol/otaa051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7380554PMC

Caregiver Strengths, Attitudes, and Concerns About Reading and Child Development in the Dominican Republic.

Glob Pediatr Health 2020 22;7:2333794X20942661. Epub 2020 Jul 22.

Children's Hospital of Philadelphia, Philadelphia, PA, USA.

. Parents' beliefs about and engagement in reading aloud to young children and other positive parenting practices have been associated with early childhood development (ECD) and later achievement. . Read More

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http://dx.doi.org/10.1177/2333794X20942661DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7376378PMC

Pica/Pagophagia-Associated Hyponatremia: Patient Presenting With Seizure.

Cureus 2020 Jul 21;12(7):e9330. Epub 2020 Jul 21.

Internal Medicine/Pulmonary and Critical Care Medicine, Texas Tech University Health Sciences Center, Lubbock, USA.

Pica is an unusual condition in which patients crave and chew substances with no nutritional value. Ice pica (pagophagia) is commonly seen in patient with iron deficiency. People chew ice cubes or add ice to their drinks to cool or refresh themselves, and they may not consider this as an abnormal behavior. Read More

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http://dx.doi.org/10.7759/cureus.9330DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7384452PMC

Iron Deficiency Anemia-Induced Neutropenia in Adult Female.

Cureus 2020 Jun 29;12(6):e8899. Epub 2020 Jun 29.

Internal Medicine, Hamad Medical Corporation, Doha, QAT.

Iron deficiency anemia is a common cause of anemia that develops when body stores of an iron drop too low to support normal red blood cell (RBC) production. Inadequate dietary iron, impaired iron absorption, bleeding, or loss of body iron in the urine may be the cause. Iron is a key part of red blood cells. Read More

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http://dx.doi.org/10.7759/cureus.8899DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7389146PMC

Anemia in Children with Inflammatory Bowel Disease: A Position Paper by the IBD Committee of the North American Society of Pediatric Gastroenterology, Hepatology and Nutrition.

J Pediatr Gastroenterol Nutr 2020 07 30. Epub 2020 Jul 30.

Associate Professor, Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Children's Hospital of Philadelphia, 3401 Civic Center Blvd. Philadelphia, PA 19104

Anemia is one of the most common extraintestinal manifestations of inflammatory bowel disease (IBD). It can be asymptomatic or associated with non-specific symptoms such as irritability, headaches, fatigue, dizziness and anorexia. In IBD patients, the etiology of anemia is often multifactorial. Read More

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http://dx.doi.org/10.1097/MPG.0000000000002885DOI Listing

Novel rigidizing overtube for colonoscope stabilization and loop prevention (with video).

Gastrointest Endosc 2020 Jul 30. Epub 2020 Jul 30.

Stanford University, Stanford CA, United States; Veterans Affairs Palo Alto, Palo Alto CA, United States.

Background And Aims: Loop formation can impede scope advancement, destabilize the tip and cause pain. Strategies to mitigate looping include torque-based reduction maneuvers, variable stiffness shafts and abdominal splinting. In some cases, these strategies are insufficient and there is need for novel instruments. Read More

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http://dx.doi.org/10.1016/j.gie.2020.07.054DOI Listing

Chronic kidney disease impacts health-related quality of life of children in Uganda, East Africa.

Pediatr Nephrol 2020 Jul 31. Epub 2020 Jul 31.

Department of Pediatrics, Renal Section, Texas Children's Hospital/Baylor College of Medicine, Houston, TX, USA.

Background: Limited data exist about causes of chronic kidney disease (CKD) and impact on health-related quality of life (HRQoL) in African children. We evaluated types of kidney disease in Ugandan children 0-18 years and compared HRQoL in children with CKD or with benign or resolving kidney disease (non-CKD) to assess predictors of HRQoL.

Methods: Demographic, socioeconomic, and clinical data were obtained for this cross-sectional study. Read More

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http://dx.doi.org/10.1007/s00467-020-04705-1DOI Listing

Idiopathic intracranial hypertension in patients with anemia: A retrospective observational study.

PLoS One 2020 31;15(7):e0236828. Epub 2020 Jul 31.

Department of Neurology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.

Idiopathic intracranial hypertension (IIH) mostly affects obese women in childbearing age, leading to frustrating headache and permanent visual impairment. The exact etiology of this condition is poorly understood, and the population at risk and clinical presentation seems to be homogeneous. However, little attention has been paid to the clinical features of IIH patients with anemia. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0236828PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7394431PMC

Iron Administration, Infection, and Anemia Management in CKD: Untangling the Effects of Intravenous Iron Therapy on Immunity and Infection Risk.

Kidney Med 2020 May-Jun;2(3):341-353. Epub 2020 Mar 27.

Division of Nephrology, Indiana University Health, Indianapolis, IN.

Patients with chronic kidney disease (CKD) are at increased risk for infection, attributable to immune dysfunction, increased exposure to infectious agents, loss of cutaneous barriers, comorbid conditions, and treatment-related factors (eg, hemodialysis and immunosuppressant therapy). Because iron plays a vital role in pathogen reproduction and host immunity, it is biologically plausible that intravenous iron therapy and/or iron deficiency influence infection risk in CKD. Available data from preclinical experiments, observational studies, and randomized controlled trials are summarized to explore the interplay between intravenous iron and infection risk among patients with CKD, particularly those receiving maintenance hemodialysis. Read More

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http://dx.doi.org/10.1016/j.xkme.2020.01.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7380433PMC

Diagnosis, treatment, and work impact of iron deficiency anemia in a Portuguese urban community.

Porto Biomed J 2020 Jul-Aug;5(4):e064. Epub 2020 Jul 17.

EPIUnit - Publick Health Institut, University of Porto, Rua das Taipas.

Introduction: Little is known about iron deficiency anemia (IDA)'s treatment in Portugal. We aim to estimate the proportion of anemia, IDA, and iron deficiency without anemia; characterize the diagnostic procedures and prescription patterns; assess anemia's impact over work absenteeism, in a Local Health Unit.

Material And Methods: Cross-sectional study that evaluated complete blood counts, iron-containing prescriptions, comorbidities, economic failure, and disability certificates issued in 2015 at the Local Health Unit. Read More

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http://dx.doi.org/10.1097/j.pbj.0000000000000064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7386539PMC

Auranofin mitigates systemic iron overload and induces ferroptosis via distinct mechanisms.

Signal Transduct Target Ther 2020 Jul 31;5(1):138. Epub 2020 Jul 31.

Department of Nutrition, Precision Nutrition Innovation Center, School of Public Health, Zhengzhou University, 450001, Zhengzhou, China.

Iron homeostasis is essential for health; moreover, hepcidin-deficiency results in iron overload in both hereditary hemochromatosis and iron-loading anemia. Here, we identified iron modulators by functionally screening hepcidin agonists using a library of 640 FDA-approved drugs in human hepatic Huh7 cells. We validated the results in C57BL/6J mice and a mouse model of hemochromatosis (Hfe mice). Read More

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http://dx.doi.org/10.1038/s41392-020-00253-0DOI Listing

North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition Position Paper: Plant-based Milks.

J Pediatr Gastroenterol Nutr 2020 Aug;71(2):276-281

Division of Gastroenterology and Nutrition, Department of Pediatrics, University of Alberta, Alberta, Edmonton, Canada.

Parents and caretakers are increasingly feeding infants and young children plant-based "milk" (PBM) alternatives to cow milk (CM). The US Food and Drug Administration currently defines "milk" and related milk products by the product source and the inherent nutrients provided by bovine milk. Substitution of a milk that does not provide a similar nutritional profile to CM can be deleterious to a child's nutritional status, growth, and development. Read More

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http://dx.doi.org/10.1097/MPG.0000000000002799DOI Listing

Iron homeostasis and plant immune responses: recent insights and translational implications.

J Biol Chem 2020 07 30. Epub 2020 Jul 30.

Plant Pathology, Physiology, and Weed Science, Virginia Tech University, United States.

Iron (Fe) metabolism and the plant immune system are both critical for plant vigor in natural ecosystems and for reliable agricultural productivity. Mechanistic studies of plant iron homeostasis and plant immunity have traditionally been carried out in isolation from each other; however, our growing understanding of both processes has uncovered significant connections. For example, iron plays a critical role in the generation of reactive oxygen intermediates during immunity and has been recently implicated as a critical factor for immune-initiated cell death via ferroptosis. Read More

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http://dx.doi.org/10.1074/jbc.REV120.010856DOI Listing

Anemia in patients with ankylosing spondylitis, association with the activity of the inflammatory process and the severity of the disease.

Wiad Lek 2020 ;73(4):715-721

National Pirogov Memorial Medical University, Vinnytsia, Ukraine, Scientific and Research Institute of Invalid Rehabilitation (Educational Scientific Treatment Complex) of National Pirogov Memorial Medical University, Vinnytsia, Ukraine.

Objective: The aim: To estimate the prevalence of anemia in patients with ankylosing spondylitis, major pathogenetic variants and their relationship with the activity of the inflammatoryprocess and the severity of the disease.

Patients And Methods: Materials and methods: 118 patients with ankylosing spondylitis participated in the study, which performed hematologic, biochemical, immunological studies with general haemopoiesis and ferrokinetics parameters, plasma levels of CRP and IL-6.

Results: Results: It was found that in Ukrainian population of patients with ankylosing spondylitis, 28. Read More

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Effects of ferric carboxymaltose on markers of mineral and bone metabolism: a single-center prospective observational study of women with iron deficiency.

Bone 2020 Jul 27:115559. Epub 2020 Jul 27.

Division of Nephrology and Hypertension, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, 60611, USA; Center for Translational Metabolism and Health, Institute for Public Health and Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA; Jesse Brown Veterans Administration Medical Center, Chicago, Illinois 60612, USA.

Background: Two weekly infusions of ferric carboxymaltose (FCM) are commonly prescribed for treatment of iron-deficiency anemia. However, administration of FCM increases intact levels of fibroblast growth factor 23 (FGF23), which causes hypophosphatemia due to renal phosphate wasting, calcitriol deficiency and secondary hyperparathyroidism. The adverse effects of FCM on mineral metabolism and bone health emerged from case reports and secondary analyses of trials. Read More

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http://dx.doi.org/10.1016/j.bone.2020.115559DOI Listing

Association of Family Income and Risk of Food Insecurity With Iron Status in Young Children.

JAMA Netw Open 2020 Jul 1;3(7):e208603. Epub 2020 Jul 1.

Division of Paediatric Medicine and the Paediatric Outcomes Research Team (PORT), The Hospital for Sick Children, Toronto, Ontario, Canada.

Importance: Iron deficiency (ID) has the greatest prevalence in early childhood and has been associated with poor developmental outcomes. Previous research examining associations of income and food insecurity (FI) with ID is inconsistent.

Objective: To examine the association of family income and family risk of FI with iron status in healthy young children attending primary care. Read More

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http://dx.doi.org/10.1001/jamanetworkopen.2020.8603DOI Listing

Intravenous ferric carboxymaltose for iron deficiency anemia or iron deficiency without anemia after poor response to oral iron treatment: Benefits and risks in a cohort of 144 children and adolescents.

Pediatr Blood Cancer 2020 Jul 30:e28614. Epub 2020 Jul 30.

F. van den Ouweland MD, PhD, Pharmaceutical Medicine, Geneva, Switzerland.

Objective: The objective of this single-center observational study was to determine the clinical and hematologic responses to intravenous ferric carboxymaltose (FCM) in a cohort of pediatric patients with poor response to oral iron therapy. The occurrence of adverse events was systematically recorded for up to 96 hours after infusion.

Study Design: A retrospective cohort of 144 consecutive patients aged 18 months to < 18 years with iron deficiency anemia (IDA) or iron deficiency (ID) without anemia was investigated. Read More

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http://dx.doi.org/10.1002/pbc.28614DOI Listing

Supplemental Microalgal Iron Helps Replete Blood Hemoglobin in Moderately Anemic Mice Fed a Rice-Based Diet.

Nutrients 2020 Jul 27;12(8). Epub 2020 Jul 27.

Department of Animal Science, Cornell University, Ithaca, NY 14853, USA.

Iron deficiency anemia affects 1.2 billion people globally. Our objectives were to determine if (1) supplemental iron extracted from defatted microalgae ( DGM) and (2) a combination of minute amount of plant phytase and inulin could help replete hemoglobin in anemic mice. Read More

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http://dx.doi.org/10.3390/nu12082239DOI Listing

A Case for Abandoning Inpatient Fecal Occult Blood Testing.

Cureus 2020 Jun 24;12(6):e8807. Epub 2020 Jun 24.

Internal Medicine, University of Virginia School of Medicine, Charlottesville, USA.

Fecal occult blood testing (FOBT) is currently Food and Drug Administration (FDA) approved only for colorectal cancer (CRC) screening. There is now widespread off-label use of FOBT in the hospital setting as a diagnostic test. Here we present a brief case and a more detailed review of the literature arguing against inpatient FOBT. Read More

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http://dx.doi.org/10.7759/cureus.8807DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7381841PMC

Efficacy of an iron-fortified infant cereal to reduce the risk of iron deficiency anemia in young children in East Cameroon.

Food Sci Nutr 2020 Jul 4;8(7):3566-3577. Epub 2020 Jun 4.

Faculty of Medicine and Biomedical Sciences University of Yaoundé I Yaoundé Cameroon.

Complementary foods in Africa are often poor sources of bioavailable iron. We assessed the efficacy of iron-fortified wheat-based infant cereal (IC) to reduce the risk of iron deficiency anemia in children aged 18-59 months in Cameroon. A 6-month double-blind, cluster-randomized controlled trial was conducted in 2017 among anemic (hemoglobin 7-11 g/dl) but otherwise healthy children. Read More

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http://dx.doi.org/10.1002/fsn3.1639DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7382166PMC

Novel α-Thalassemia Deletion Identified in an Indian Infant with Hb H Disease.

Hemoglobin 2020 Jul 28:1-5. Epub 2020 Jul 28.

Specialist Biochemistry, Canterbury Health Laboratories, Christchurch, New Zealand.

We report the identification of a large deletion of the α-globin gene cluster, which removed both and and included the region from to on chromosome 16 (16p13.3). The α-thalassemia (α-thal) deletion was discovered in an Indian family residing in New Zealand. Read More

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http://dx.doi.org/10.1080/03630269.2020.1797774DOI Listing

Compression of the Lateral Antebrachial Cutaneous Nerve due to Leakage of Iron after an Intravenous Iron Infusion.

Diagnostics (Basel) 2020 Jul 25;10(8). Epub 2020 Jul 25.

Department of Physical Medicine and Rehabilitation, College of Medicine, Yeungnam University, Daegu 42415, Korea.

Skin staining due to iron leakage into the subcutaneous tissue can sometimes occur during intravenous iron infusion. We describe a case of lateral antebrachial cutaneous nerve (LACN) entrapment due to extravasated iron after an intravenous iron infusion. A 41-year-old woman received an intravenous ferric carboxymaltose infusion for iron deficiency anemia. Read More

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http://dx.doi.org/10.3390/diagnostics10080516DOI Listing

Correlations between Iron Metabolism Parameters, Inflammatory Markers and Lipid Profile Indicators in Patients with Type 1 and Type 2 Diabetes Mellitus.

J Pers Med 2020 Jul 25;10(3). Epub 2020 Jul 25.

Siberian State Medical University, 634050 Tomsk, Russia.

This study aims to establish relationships between inflammatory status, ferrokinetics and lipid metabolism in patients with diabetes mellitus. Subclinical inflammation was assessed by levels of high-sensitive C-reactive protein, tumor necrosis factor-α and erythrocyte sedimentation rate. Iron metabolism parameters included complete blood count, serum iron, transferrin and ferritin. Read More

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http://dx.doi.org/10.3390/jpm10030070DOI Listing

The prevalence of small-bowel polyps on video capsule endoscopy in patients with sporadic duodenal or ampullary adenomas.

Gastrointest Endosc 2020 Jul 24. Epub 2020 Jul 24.

Department of Gastroenterology and Hepatology, Westmead hospital, NSW, Australia; The University of Sydney, NSW, Australia. Electronic address:

Background And Aims: Although sporadic duodenal and/or ampullary adenomas (DAs) are uncommon, they are increasingly diagnosed during upper endoscopy. These patients have a 3- to 7-fold increased risk of colonic neoplasia as compared with the normal population. It is unknown, however, whether they also have an increased risk of additional small-bowel (SB) polyps. Read More

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http://dx.doi.org/10.1016/j.gie.2020.07.029DOI Listing

Iron deficiency induces female infertile in order to failure of follicular development in mice.

J Reprod Dev 2020 Jul 23. Epub 2020 Jul 23.

Graduate School of Comprehensive Scientific Research, Prefectural University of Hiroshima, Hiroshima 727-0023, Japan.

Iron is important for many cellular functions, including ATP synthesis and cell proliferation. Insufficient of iron in the diet causes iron deficiency anemia (IDA), which often occurs in people living in the world. Since 50% of women with IDA show amenorrhea, the relationship of between iron deficiency and reproductive function was assessed using mice fed a low Fe diet (LFD). Read More

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http://dx.doi.org/10.1262/jrd.2020-074DOI Listing

How to implement of patient blood management pillar 1: An Italian expert opinion based on a "bundles" approach.

Transfus Apher Sci 2020 Jul 15:102874. Epub 2020 Jul 15.

Tranfusion Medicine and Cellular Therapy, University Campus BioMedico, Italy.

Worldwide iron anemia is a common disorder with a significant economic burden on health-care systems. Red blood cell transfusion is the mainstay to correct anemia in surgical settings, but it is also an overused procedure and recent data support its possible role in worsening patient outcomes. Patient Blood Management (PBM) is a multidisciplinary approach to optimize hemostasis, manage anemia, minimize iatrogenic blood loss, and improve tolerance to anemia. Read More

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http://dx.doi.org/10.1016/j.transci.2020.102874DOI Listing

[A gastric mass].

Rev Med Interne 2020 Jul 22. Epub 2020 Jul 22.

Service de chirurgie Générale, Centre de traumatologie et grands brulés Ben Arous, Université de Tunis El Manar, Tunisie.

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http://dx.doi.org/10.1016/j.revmed.2020.06.003DOI Listing