22,394 results match your criteria Iron Deficiency Anemia


A Systematic Review, Meta-Analysis, and Indirect Comparison of Blindly Adjudicated Cardiovascular Event Incidence with Ferric Derisomaltose, Ferric Carboxymaltose, and Iron Sucrose.

Adv Ther 2022 Aug 10. Epub 2022 Aug 10.

Department of Cardiology, Manchester Academic Health Science Centre, Manchester University NHS Foundation Trust, Manchester, UK.

Introduction: Intravenous (IV) iron is the preferred treatment for patients with iron deficiency anemia (IDA) who require rapid replenishment of iron stores or in whom oral iron is not tolerated or effective. Data from two large-scale randomized controlled trials (RCTs) have recently been published reporting the incidence of adjudicated cardiovascular events after ferric derisomaltose (FDI) and iron sucrose (IS). The objective was to calculate the relative incidence of cardiovascular events with FDI and IS, and to conduct an indirect comparison with ferric carboxymaltose (FCM) based on previously published studies of cardiovascular risk. Read More

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Rheumatologic Manifestations with Elevated Levels of IL-6, IL-17A, and IL-23 in a Patient with Scurvy.

Mod Rheumatol Case Rep 2022 Aug 9. Epub 2022 Aug 9.

Department of Pediatrics, Hokkaido University Hospital, Japan.

Symptomatic vitamin C deficiency, scurvy, is a relatively rare disease in developed countries, but it has been reported in patients with autism spectrum disorder or developmental delay who tend to have selective diets. Patients with scurvy often demonstrate musculoskeletal manifestations with unknown pathophysiology. Herein, we report a case of scurvy in an 11- year-old boy who presented with iron-deficiency anemia, systemic osteomyelitis, myositis predominantly in the lower extremities, and right ventricular volume overload with mild pulmonary hypertension and, was diagnosed with scurvy. Read More

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Gastric Pseudomelanosis: An Uncommon Finding.

Case Rep Gastrointest Med 2022 30;2022:6290510. Epub 2022 Jul 30.

Division of Gastroenterology and Hepatology, Geisinger Medical Center, Danville, PA, USA.

Gastric pseudomelanosis is a benign condition that has been characterized by pigment deposition within subepithelial macrophages inside the stomach wall. Occurrence of the condition is rare, with pseudomelanosis occurring more often within the duodenal mucosa. Few cases have reported pseudomelanosis within the gastric mucosa. Read More

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The first reported case of left renal vein fenestration.

Surg Radiol Anat 2022 Aug 8. Epub 2022 Aug 8.

Department of Radiology, Faculty of Medicine, Eskişehir Osmangazi University, Meşelik Yerleşkesi, 26480, Eskişehir, Turkey.

Purpose: Vascular fenestrations are mostly seen in the arterial system and cerebral vessels, but they can be seen rarely in the venous system. In this article, we aimed to present the first case of left renal vein fenestration, which has not been previously reported in the English literature to the best our knowledge.

Methods: Computed tomography angiography (CTA) examination was performed on a 40-year-old male patient who presented with rectal bleeding, and iron deficiency anemia, detected hemorrhoids in colonoscopy, and was planned for superior rectal artery embolization. Read More

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The Evaluation of Results of Twenty Common Equations for Differentiation of Beta Thalassemia Trait from Iron Deficiency Anemia: A Cross-Sectional Study.

Iran J Public Health 2022 Apr;51(4):929-938

School of Public Health, Khoy University of Medical Sciences, Khoy, Iran.

Background: Beta Thalassemia Trait (BTT) and Iron Deficiency Anemia (IDA) were two common clinical problems with clinical hypochromic and microcytic manifestations, and their differentiation from each other was very important and needs innovative formulas and laboratory tests. Since the consideration of anemia as a pair with BTT leads to beta-thalassemia major birth in 25% of cases, offering prospective parents detailed information about the likelihood of their offspring developing BTT is essential. The present study aimed to investigate the performance of common equations in differentiation of BTT from IDA. Read More

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Small vessel vasculitis associated with culture-negative infective endocarditis related to a cardiac device: a case report.

Eur Heart J Case Rep 2022 Aug 2;6(8):ytac294. Epub 2022 Aug 2.

Cardiology Department, Calderdale and Huddersfield NHS Foundation Trust, Halifax, HD3 3EA, UK.

Background: Culture-negative endocarditis is uncommon, occurring in less than a third of all cases of infective endocarditis (IE). Culture-negative IE related to a cardiac device is an even greater diagnostic challenge due to its insidious presentation, with onset of symptoms ranging between 3 and 12 months after device implantation. Sensitivity of the modified Duke's criteria remains low in culture-negative and cardiac device-related IE (CDRIE) since classical signs and symptoms of IE are often absent. Read More

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Not Your Typical Nosebleed: A Case Report and Personal Account of a Patient With Osler-Weber-Rendu Syndrome.

Perm J 2022 Jun 15;26(2):138-143. Epub 2022 Jun 15.

Department of Otolaryngology-Head and Neck Surgery, Kaiser Permanente, Vallejo, CA, USA.

Introduction Osler-Weber-Rendu syndrome, or hereditary hemorrhagic telangiectasia, is a rare genetic disease that causes recurrent epistaxis and anemia. Numerous bleeding vascular malformations can be found throughout the body. Case presentation A 75-year-old woman presented to her hematologist with recurrent epistaxis, iron deficiency anemia, menorrhagia, and hypothyroidism. Read More

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Preparation, characterization and bioavailability studies of Tegillarca granosa hemoglobin and its glycosylated products.

Int J Biol Macromol 2022 Aug 2;219:11-20. Epub 2022 Aug 2.

College of Food and Pharmaceutical Sciences, Ningbo University, 315211, China; Key Laboratory of Animal Protein Food Deep Processing Technology of Zhejiang Province, Ningbo University, Ningbo 315211, China. Electronic address:

Iron deficiency anemia (IDA) is a common micronutrient deficiency. Tegillarca granosa (T. granosa) is a good source of iron due to its high content of hemoglobin. Read More

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The association between iron status and thyroid hormone levels during pregnancy.

J Trace Elem Med Biol 2022 Jul 22;74:127047. Epub 2022 Jul 22.

School of Public Health, Guangxi Medical University, Nanning, Guangxi, China. Electronic address:

Background: Iron deficiency may be a risk factor for thyroid disorder; however, the relationship between iron deficiency and thyroid disorder as well as mechanism involved remain unclear.

Methods: A hospital-based cross-sectional study was conducted to analyze the correlation between iron status and thyroid hormone levels in pregnant women. A total of 2218 pregnant women were recruited, and iron status and thyroid hormones were measured. Read More

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Ironing It All Out: A Comprehensive Review of Iron Deficiency Anemia in Inflammatory Bowel Disease Patients.

Dig Dis Sci 2022 Aug 5. Epub 2022 Aug 5.

Johns Hopkins Hospital, Baltimore, MD, USA.

Iron deficiency anemia affects approximately 45% of patients with inflammatory bowel disease (IBD), negatively impacts the quality of life in this patient population, and significantly burdens our healthcare system. The pathogenesis of iron deficiency in IBD patients is multifactorial, including intestinal bleeding, malabsorption, and inadequate oral intake. Regular screening and diagnosis in these patients are imperative, and often patients have mixed iron deficiency anemia and anemia of chronic disease, especially in those with active inflammation. Read More

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Relationship between active infection and anemia, iron deficiency, iron deficiency anemia: A cross-sectional study in a sub-Saharan setting.

JGH Open 2022 Aug 15;6(8):554-568. Epub 2022 Jul 15.

Medical Microbiology Laboratory, Department of Microbiology, Faculty of Science University of Yaoundé I Yaoundé Cameroon.

Background And Aim: There have been contradictory reports about the association between infection and iron deficiency anemia (IDA). Based on the high frequency of infection in Cameroon, we have evaluated the frequency of infection as the cause of anemia, and IDA among dyspeptic patients in Cameroon.

Methods: This cross-sectional study enrolled 842 dyspeptic patients (472 women and 370 men) in two reference hospitals in Douala-Cameroon. Read More

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Knowledge on anaemia and benefit of iron-folic acid supplementation among pregnant mothers attending antenatal care in Woldia town, Northeastern Ethiopia: a facility-based cross-sectional study.

J Health Popul Nutr 2022 Aug 4;41(1):32. Epub 2022 Aug 4.

Department of Midwifery, College of Health Sciences, Injibara University, P.O. Box: 40, Injibara, Ethiopia.

Background: Anaemia in pregnancy is the leading cause of maternal morbidity and mortality and poor birth outcomes in low- and middle-income countries. The most common cause of anaemia during pregnancy is acute blood loss and iron deficiency due to physiological changes and increasing demand for iron on the mother and growing foetus. Iron and folic acid supplementation is the most widely employed strategy to alleviate iron deficiency anaemia during pregnancy. Read More

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Optimization of a Quality Improvement Tool for Cancer Diagnosis in Primary Care: Qualitative Study.

JMIR Form Res 2022 Aug 4;6(8):e39277. Epub 2022 Aug 4.

Centre for Cancer Research, Victorian Comprehensive Cancer Centre, University of Melbourne, Melbourne, Australia.

Background: The most common route to a diagnosis of cancer is through primary care. Delays in diagnosing cancer occur when an opportunity to make a timely diagnosis is missed and is evidenced by patients visiting the general practitioner (GP) on multiple occasions before referral to a specialist. Tools that minimize prolonged diagnostic intervals and reduce missed opportunities to investigate patients for cancer are therefore a priority. Read More

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The prevalence of perioperative iron deficiency anaemia in women undergoing caesarean section-a retrospective cohort study.

Perioper Med (Lond) 2022 Aug 4;11(1):36. Epub 2022 Aug 4.

Barwon Health, Ryrie Street, Geelong, Victoria, 3220, Australia.

Background: Caesarean section is a common surgery, with almost 23 million procedures performed globally each year. Postpartum haemorrhage, in association with caesarean section surgery, is a leading global cause of maternal morbidity and mortality. Perioperative iron deficiency anaemia is a risk factor for intraoperative bleeding. Read More

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Effect of change in individual and household level characteristics on anemia prevalence among adolescent boys and girls in India.

BMC Public Health 2022 08 3;22(1):1478. Epub 2022 Aug 3.

Department of Fertility Studies, International Institute for Population Sciences, Mumbai, Maharashtra, India.

Background: Anemia is a significant public health challenge that affects the population of all nations. Anemia among adolescents emerged as an alarming public health issue as it harms an individual's physical capacity and cognitive and work performance. The study aims to determine the effect of changes in individual and household level factors on the prevalence of anemia among adolescent boys and girls. Read More

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Maternal iron deficiency anaemia in pregnancy: Lessons from a national audit.

Br J Haematol 2022 Aug 3. Epub 2022 Aug 3.

Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford, UK.

We describe the management and the prevalence of iron deficiency anaemia (IDA) during pregnancy by comparison to standards. A cross-sectional national cohort study of women who had given birth six weeks prior to data collection was conducted at maternity units in the UK and Ireland. Participating centres collected data from 10 consecutive pregnant women. Read More

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Levels of Lead in Residential Drinking Water and Iron Deficiency among Patients with End Stage Kidney Disease.

Kidney360 2022 07 29;3(7):1210-1216. Epub 2022 Apr 29.

Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.

Background: Although those with kidney disease may have heightened susceptibility to heavy metal toxicity, whether low levels of drinking water lead contamination have clinical consequence is unknown.

Methods: Given that lead toxicity is known to associate with iron deficiency, we merged data from the Environmental Protection Agency (EPA) Safe Drinking Water Information and United States Renal Data Systems to examine whether municipal 90th percentile drinking water lead levels associate with iron deficiency among incident dialysis patients. Iron deficiency was defined across thresholds of transferrin saturation (<10% and 20%) and ferritin (<100 and <200 ng/ml), and simultaneous transferrin saturation <20% and ferritin <200 ng/ml, all obtained within 30 days of dialysis initiation. Read More

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High Prevalence of Congenital Factor VII (FVII) Deficiency in Adolescent Females with Heavy Menstrual Bleeding and Iron Deficiency Anemia.

J Pediatr Adolesc Gynecol 2022 Jul 30. Epub 2022 Jul 30.

Holtz Children's Hospital - Jackson Memorial Medical Center. Miami, FL; Division of Pediatric Hematology-Oncology, Department of Pediatrics. University of Miami - Miller School of Medicine. Miami, FL; University of Miami - Hemophilia Treatment Center. Mami, FL. Electronic address:

Study Objective: To examine the clinical characteristics and prevalence of congenital bleeding disorders (CBDs), with emphasis on congenital factor VII (FVII) deficiency and other rare bleeding disorders, in adolescent and young adult females referred to a Hemophilia Treatment Center (HTC) for evaluation and management of heavy menstrual bleeding (HMB) and iron deficiency anemia (IDA).

Design: This single-center retrospective study reviewed the clinical characteristics and prevalence of CBDs in post-menarcheal females, younger than 22-years-of-age, referred to an HTC from 2015 to 2021 for evaluation of HMB with or without IDA.

Results: One hundred females, mean age of 15 years (range 9 to 20 years), met initial study criteria with 95 included in the final analysis. Read More

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Iron status of blood donors.

Curr Opin Hematol 2022 Jul 25. Epub 2022 Jul 25.

Versiti Blood Research Institute.

Purpose Of Review: This review examines recent research on the prevalence and importance of iron deficiency in blood donors, and on efforts to mitigate it.

Recent Findings: Premenopausal females, teenagers, and high-frequency donors are at the highest risk for donation-induced iron deficiency, in both high-resource and low-resource settings. The physiology relating iron stores to hemoglobin levels and low hemoglobin deferral is well elucidated in blood donor populations, yet the clinical effects attributable to iron loss in the absence of anemia are challenging to identify. Read More

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Celiac disease and idiopathic pulmonary hemosiderosis: a literature review of the Lane-Hamilton syndrome.

Postgrad Med 2022 Aug 8:1-11. Epub 2022 Aug 8.

Pulmonary Department, "G. Papanikolaou" General Hospital, Thessaloniki, Greece.

Lane-Hamilton syndrome (LHS) presents a medical emergency, with 14% mortality due to Idiopathic Pulmonary Hemosiderosis (IPH) in acute phase. Despite the clinical severity of this entity, there has been no published review in the international literature, resulting in lack of awareness and delayed diagnosis.A rigorous search of international databases yielded a total of 80 LHS cases from January 1971 to August 2020. Read More

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Effect of Picture-based health education and counselling on knowledge and adherence to preconception Iron-folic acid supplementation among women planning to be pregnant in Eastern Ethiopia: a randomized controlled trial.

J Nutr Sci 2022 13;11:e58. Epub 2022 Jul 13.

Department of Nutrition and Dietetics, Faculty of Public Health, Institute of Health, Jimma University, Jimma, Ethiopia.

The present study examined the effect of picture-based nutrition education on knowledge and adherence to pre-conception iron-folic acid supplement (IFAS) in Ethiopia, a country where there is a high burden of neural tube defects (NTDs) and anaemia. In eastern Ethiopia, a parallel randomised controlled trial design was employed among women planning to get pregnant. The interventional arm ( 122) received a preconception picture-based nutrition education and counselling along with an IFAS and the control arm ( 122) received only a preconception IFAS. Read More

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Gastric Th17 Cells Specific for H/K-ATPase and Serum IL-17 Signature in Gastric Autoimmunity.

Front Immunol 2022 11;13:952674. Epub 2022 Jul 11.

Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.

Human gastric autoimmunity [autoimmune gastritis (AIG)] is characterized by inflammation of the gastric mucosa and parietal cell loss. The gastric parietal cell proton pump H/K-adenosine triphosphatase (H/K-ATPase) is the major autoantigen in AIG. Our work aimed to investigate the gastric H/K-ATPase-specific T helper 17 (Th17) responses in AIG and serum interleukin (IL)-17 cytokine subfamily in AIG patients, in healthy subjects [healthy controls (HCs)], and in patients with iron deficiency anemia (IDA) without AIG. Read More

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Dietary iron intakes and odds of iron deficiency anaemia among pregnant women in Ifako-Ijaiye, Lagos, Nigeria: a cross-sectional study.

Pan Afr Med J 2022 11;42:23. Epub 2022 May 11.

The Postgraduate College University of Ibadan, University of Ibadan, Ibadan, Nigeria.

Introduction: iron deficiency anaemia (IDA) in pregnancy is a prominent risk factor for maternal mortality and poor pregnancy outcomes in low- and middle-income countries, but studies on the significance of dietary iron intake (DII) in IDA in this population are limited. This study assessed the association of DII with odds of IDA among pregnant women attending primary health centres in Ifako-Ijaiye, Lagos, Nigeria.

Methods: sociodemographic information and dietary intakes were assessed among 432 singleton pregnant women (without pre-existing medical complications) using a pre-tested questionnaire and 24 hr-dietary recall, respectively. Read More

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Evaluation of the use of non-invasive hemoglobin measurement in early childhood.

Pediatr Res 2022 Jul 29. Epub 2022 Jul 29.

Department of Pediatrics and Adolescent Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan.

Background: Iron deficiency anemia in children affects psychomotor development. We compared the accuracy and trend of a non-invasive transcutaneous spectrophotometric estimation of arterial hemoglobin (Hb) concentration (SpHb) by rainbow pulse CO-oximetry technology to the invasive blood Hb concentration measured by an automated clinical analyzer (Hb-Lab).

Methods: We measured the SpHb and Hb-Lab in 109 patients aged 1-5 years. Read More

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Hepcidin and Iron in Health and Disease.

Annu Rev Med 2022 Jul 29. Epub 2022 Jul 29.

Center for Iron Disorders, Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA; email:

Hepcidin, the iron-regulatory hormone, determines plasma iron concentrations and total body iron content. Hepcidin, secreted by hepatocytes, functions by controlling the activity of the cellular iron exporter ferroportin, which delivers iron to plasma from intestinal iron absorption and from iron stores. Hepcidin concentration in plasma is increased by iron loading and inflammation and is suppressed by erythropoietic stimulation and during pregnancy. Read More

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Beyond Screening: An Interim Report and Analysis of a Multimodal Initiative to Decrease Colon Cancer Mortality.

Jt Comm J Qual Patient Saf 2022 Aug 9;48(8):388-394. Epub 2022 Jun 9.

Background: Colon cancer, a potentially preventable and curable cancer, remains one of the leading causes of cancer-related death in the United States. In 2010 the researchers undertook a multifaceted initiative to reduce colon cancer mortality rates by 50% over 10 years.

Methods: A baseline literature review of preventable causes of colon cancer mortality and review of 50 deaths from colon cancer in one institution identified a set of care process improvements that could be implemented to decrease colon cancer mortality. Read More

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An unusual case of multiple gastrointestinal stromal tumors in the small bowel presenting as occult and overt gastrointestinal bleeding.

Clin Case Rep 2022 Jul 22;10(7):e6082. Epub 2022 Jul 22.

Department of Gastroenterology and Hepatology Monash Health Clayton Victoria Australia.

We present a case report of a 59-year-old woman with multiple gastrointestinal stromal tumors as a cause of gastrointestinal bleeding. She initially presented with recurrent iron deficiency anemia and subsequent gastrointestinal bleeding over 10 years. An initial angiodysplastic lesion was identified, treated, and spot tattooed. Read More

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The association of iron deficiency anemia and perioperative complications following revision total knee arthroplasty.

Arthroplasty 2022 Jul 27;4(1):34. Epub 2022 Jul 27.

Department of Orthopaedic Surgery, Maimonides Medical Center, 927 49th Street, Brooklyn, NY, 11219, USA.

Background: Recent studies show an increase in the prevalence of iron deficiency anemia (IDA) worldwide and a concomitant rise in the number of revision total knee arthroplasty (RTKA). The literature evaluating the association between IDA and perioperative outcomes following RTKA are limited. Therefore, the purpose of this study was to determine whether IDA patients undergoing RTKA have higher rates of (1) in-hospital lengths of stay (LOS), (2) complications; and (3) costs. Read More

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The effect of intravenous iron supplementation on exercise capacity in iron-deficient but not anaemic patients with chronic kidney disease: study design and baseline data for a multicentre prospective double-blind randomised controlled trial.

BMC Nephrol 2022 07 27;23(1):268. Epub 2022 Jul 27.

King's College Hospital NHS Trust, London, UK.

Background: Many people living with chronic kidney disease (CKD) are iron deficient, even though they may not be anaemic. The Iron and Muscle study aims to evaluate whether iron supplementation reduces symptoms of fatigue, improves muscle metabolism, and leads to enhanced exercise capacity and physical function. We report here the trial design and baseline characteristics. Read More

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