18,956 results match your criteria Iron Deficiency Anemia


Anemia in Bolivian children: a comparative analysis among three regions of different altitudes.

Ann N Y Acad Sci 2019 Mar 18. Epub 2019 Mar 18.

Division of Food Security and Agriculture, RTI International, Washington DC.

Here, we analyzed four population-based demographic and health surveys conducted in Bolivia between 1998 and 2016 to understand trends in anemia in children from 6 to 59 months of age by selected sociodemographic characteristics and three categories of altitude: low, medium, and high. Over the 18-year period, the prevalence of anemia was virtually unchanged while that in children living at high altitude increased. Anemia in children living at all three altitude categories is more than 40% and a severe public health problem according to the World Health Organization. Read More

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http://dx.doi.org/10.1111/nyas.14038DOI Listing

Safety profile of iron polymaltose infusions.

Hosp Pract (1995) 2019 Mar 18:1-3. Epub 2019 Mar 18.

d Department of Pharmacy , Western Hospital , Melbourne , Australia.

Objectives: Iron polymaltose infusions are one type of iron infusate used to treat iron deficiency used in countries such as Australia. We looked at the safety profile of this infusion at one metropolitan hospital in Melbourne, Australia and the associated demographics of those who had reactions.

Methods: A retrospective review of the medical records all adult patients who had an iron polymaltose infusion at Western Hospital over 12 months was performed. Read More

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http://dx.doi.org/10.1080/21548331.2019.1593006DOI Listing

Ferric carboxymaltose in the treatment of iron deficiency in pediatric inflammatory bowel disease.

Transl Pediatr 2019 Jan;8(1):28-34

Department of Gastroenterology, Queensland Children's Hospital, South Brisbane, Queensland, Australia.

Background: Iron deficiency (ID) with or without anemia is a common complication of pediatric inflammatory bowel disease (IBD), causing significant morbidity. Despite this, ID remains prevalent and undertreated, related in part to questions surrounding optimal formulation and route of administration. Ferric carboxymaltose (FCM) is a recent formulation of intravenous iron, allowing higher doses and rapid infusion times. Read More

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http://dx.doi.org/10.21037/tp.2019.01.01DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382504PMC
January 2019

Frequency and causes of anemia in Lymphoma patients.

Pak J Med Sci 2019 Jan-Feb;35(1):61-65

Dr. Neelam Siddiqui, MRCP, FRCP, CCST (Medical Oncology), Consultant Oncologist, Department of Medical Oncology, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan.

Objective: Purpose of this study was to find out frequency of anemia and its causes in newly diagnosed treatment naive lymphoma patients.

Methods: We retrospectively studied all lymphoma patients (> 18 years age) diagnosed and treated at Shaukat Khanum Memorial Cancer Hospital and Research Centre, from January 2016 till January 2017. The data was collected from electronic Hospital Information System. Read More

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http://dx.doi.org/10.12669/pjms.35.1.91DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408630PMC

Prevalence and risk factors of anemia and zinc deficiency among 4-6-year-old children of Allahabad District, Uttar Pradesh.

Indian J Public Health 2019 Jan-Mar;63(1):79-82

Professor, Centre of Food Technology, University of Allahabad, Allahabad, Uttar Pradesh, India.

Anemia and zinc deficiency are two of the most daunting nutritional problems afflicting the young children among developing countries like India. Thus, in view of this the following study was designed to investigate the status of undernutrition and micronutrient status (iron and zinc) of children aged between 4 and 6 years of Allahabad district. The anthropometric measurements (height and weight); biochemical parameters (hemoglobin and serum zinc), and general information of the children were recorded. Read More

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http://dx.doi.org/10.4103/ijph.IJPH_342_17DOI Listing

Meta-analysis of efficacy of iron and iodine fortified salt in improving iron nutrition status.

Indian J Public Health 2019 Jan-Mar;63(1):58-64

Professor and Head, Centre for Community Medicine, All India Institute of Medical Sciences, New Delhi, India.

Background: Salt fortification with iron is a potential strategy to increase population-level iron intake. The current evidence regarding double-fortified salt (DFS) in improving iron nutrition status is equivocal.

Objective: To study the efficacy of DFS as compared to iodine fortified salt (IS) in improving iron nutrition status. Read More

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http://dx.doi.org/10.4103/ijph.IJPH_420_17DOI Listing

Improving Anemia in Inflammatory Bowel Disease: Impact of the Anemia Care Pathway.

Dig Dis Sci 2019 Mar 16. Epub 2019 Mar 16.

Michael E. DeBakey Veterans Affairs Medical Center, 2002 Holcombe Blvd, Houston, TX, 77030, USA.

Background: Anemia is a common complication of inflammatory bowel disease (IBD). Despite existing guidelines for anemia in IBD, it is frequently under-treated and the prevalence of anemia has remained high. To address this gap, the Crohn's and Colitis Foundation developed the Anemia Care Pathway (ACP). Read More

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http://dx.doi.org/10.1007/s10620-019-05559-wDOI Listing
March 2019
2.550 Impact Factor

Lanthanum phosphate binder-induced iron deficiency anaemia.

BMJ Case Rep 2019 Mar 15;12(3). Epub 2019 Mar 15.

US Air Force Hospital Keesler AFB, Keesler AFB, Mississippi, USA.

Lanthanum carbonate is a phosphate binder that is used to reduce serum phosphate levels in patients with end-stage renal disease (ESRD). Lanthanum forms insoluble lanthanum phosphate complexes that are supposed to pass through the gastrointestinal (GI) tract unabsorbed. Phosphate binders have been reported to deposit in the GI tract and can cause mucosal injury. Read More

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http://dx.doi.org/10.1136/bcr-2018-226157DOI Listing

Gastric cancer and paraneoplastic dermatomyositis as complications of an unrecognized juvenile polyposis syndrome.

Z Gastroenterol 2019 Mar 14. Epub 2019 Mar 14.

Department of Medicine II, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany.

Juvenile polyposis syndrome is a rare autosomal-dominant disorder characterized by multiple hamartomatous polyps in the gastrointestinal tract. It is associated with an increased risk of gastrointestinal cancer. We report the case of a 49-year-old woman presenting with proximal muscle weakness, weight loss, severe anemia, and melena. Read More

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http://dx.doi.org/10.1055/a-0855-4404DOI Listing

Pica: A common condition that is commonly missed - An update review.

Curr Pediatr Rev 2019 Mar 13. Epub 2019 Mar 13.

Department of Paediatrics, The Chinese University of Hong Kong, Shatin. Hong Kong.

Background: Pica is a common condition in childhood that is commonly missed.

Objective: To familiarize physicians with the clinical evaluation and management of children with pica.

Methods: A PubMed search was completed in Clinical Queries using the key term "pica" OR "dirt-eating". Read More

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http://dx.doi.org/10.2174/1573396315666190313163530DOI Listing
March 2019
1 Read

Association of Zinc Deficiency with Iron Deficiency Anemia and its Symptoms: Results from a Case-control Study.

Cureus 2019 Jan 2;11(1):e3811. Epub 2019 Jan 2.

Internal Medicine, Zagazig University Hospitals, Zagazig, EGY.

Iron deficiency anemia (IDA) is the most common type of anemia. Impaired iron absorption can be caused by a decrease in trace elements as zinc, which is found in the structure of enzymes that coordinate or catalyst iron metabolism. The aim of this study is to detect if zinc deficiency is associated with IDA and to determine the effect of associated zinc deficiency on symptoms of IDA in adult IDA patients. Read More

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http://dx.doi.org/10.7759/cureus.3811DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402732PMC
January 2019
1 Read

[Patient Blood Management: Preoperative Anemia and Case Reports from the Anemia Walk-In Clinic].

Anasthesiol Intensivmed Notfallmed Schmerzther 2019 Mar 13;54(3):182-193. Epub 2019 Mar 13.

Preoperative anemia is independently associated with increased morbidity and mortality and represents the strongest predictor for transfusion of red blood cells. Iron deficiency anemia is the most frequent form of anemia and could easily be treated by supplementation with iron. Patient Blood Management (PBM) focusses on prevention and management of anemia to optimize the patient and reduce unnecessary allogeneic blood products. Read More

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http://dx.doi.org/10.1055/a-0593-4354DOI Listing
March 2019
1 Read

Effects of micronised microencapsulated ferric pyrophosphate supplementation in patients with advanced cancer and iron deficiency: a single-centre cohort pilot study.

Blood Transfus 2019 Feb 18. Epub 2019 Feb 18.

Department of Medical and Surgical Sciences and Advanced Technologies "G.F. Ingrassia", Section of Haematology, University Hospital "Policlinico-Vittorio Emanuele", University of Catania, Catania, Italy.

Background: Iron deficiency is the most common nutritional deficiency in advanced cancer patients and causes anaemia. Iron deficiency anaemia treatment (i.e. Read More

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http://dx.doi.org/10.2450/2019.0181-18DOI Listing
February 2019

Prevalence and Genetic Analysis of - and -Thalassemia and Sickle Cell Anemia in Southwest Iran.

J Epidemiol Glob Health 2018 Dec;8(3-4):189-195

Research Center of Thalassemia and Hemoglobinopathies, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

This prospective study assessed the prevalence and genetic analysis of - and -thalassemia and sickle cell anemia (SCA) in Southwest Iran. Hematological indices were measured in 17,581 couples living in Khuzestan Province, Southwest Iran. Individuals with mean corpuscular volume <80, mean corpuscular hemoglobin <27, hemoglobin A2 ≥3/5 were considered as -thalassemia traits. Read More

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http://dx.doi.org/10.2991/j.jegh.2018.04.103DOI Listing
December 2018
2 Reads

Iron status and associations with physical performance during basic combat training in female New Zealand Army recruits.

Br J Nutr 2019 Mar 13:1-7. Epub 2019 Mar 13.

2School of Sport,Exercise and Nutrition,College of Health,Massey University,North Shore,Auckland 0745,New Zealand.

Decreases in Fe status have been reported in military women during initial training periods of 8-10 weeks. The present study aimed to characterise Fe status and associations with physical performance in female New Zealand Army recruits during a 16-week basic combat training (BCT) course. Fe status indicators - Hb, serum ferritin (sFer), soluble transferrin receptor (sTfR), transferrin saturation (TS) and erythrocyte distribution width (RDW) - were assessed at the beginning (baseline) and end of BCT in seventy-six volunteers without Fe-deficiency non-anaemia (sFer 10 mg/l at baseline or end. Read More

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http://dx.doi.org/10.1017/S0007114519000199DOI Listing
March 2019
1 Read

[Severe asymptomatic iron deficiency anemia as an unusual presentation of a Meckel diverticulum].

Rev Gastroenterol Peru 2018 Oct-Dec;38(4):365-369

Clínica Javier Prado. Lima, Perú.

Meckel's diverticulum is a rare clinical entity in clinical practice. However, it should be considered as an important differential diagnosis in patients with both obscure overt and occult gastrointestinal bleeding. Years ago, the evaluation of the small bowel was impossible without surgery, nowadays the development of new diagnostic methods has changed this horizon. Read More

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March 2019
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Ethnic prevalence of anemia and predictors of anemia among chronic kidney disease patients at a tertiary hospital in Johannesburg, South Africa.

Int J Nephrol Renovasc Dis 2019 18;12:19-32. Epub 2019 Feb 18.

Department of Internal Medicine, School of Clinical Medicine, Faculty of Health Science, University of the Witwatersrand, Johannesburg, South Africa,

Introduction: Anemia is a complication of chronic kidney disease (CKD) that can greatly impact on its prognosis. However, the risk factors for anemia, including the influence of ethnicity, are not well established among the CKD population in Johannesburg.

Methods: This was a cross-sectional study of 353 adult CKD patients attending the renal outpatient clinic of the Charlotte Maxeke Johannesburg Academic Hospital (Johannesburg, South Africa) from June 1, 2016 to December 30, 2016. Read More

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http://dx.doi.org/10.2147/IJNRD.S179802DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385786PMC
February 2019
2 Reads

Impact of Preoperative Iron Deficiency on Blood Transfusion in Elective Cardiac Surgery.

J Cardiothorac Vasc Anesth 2019 Feb 11. Epub 2019 Feb 11.

CHU Rennes, Anesthésie-Réanimation CTCV, F-35033 Rennes, France; Inserm CIC-1414, F-35000 Rennes, France; Université de Rennes 1, Faculté de Médecine, F-35000 Rennes, France.

Objective: To evaluate the incidence and consequences of preoperative iron deficiency in elective cardiac surgery.

Design: A prospective observational study.

Setting: The cardiac surgery unit of a university hospital, from November 2016 to February 2017. Read More

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http://dx.doi.org/10.1053/j.jvca.2019.02.006DOI Listing
February 2019
2 Reads

Relative hypochromia and mortality in acute heart failure.

Int J Cardiol 2019 Feb 27. Epub 2019 Feb 27.

Department of Cardiology and Cardiovascular Research Institute Basel (CRIB), University Hospital Basel, University of Basel, Switzerland. Electronic address:

Background: Relative hypochromia of erythrocytes defined as a reduced mean corpuscular hemoglobin concentration (MCHC) is a surrogate of iron deficiency. We aimed to evaluate the prevalence and prognostic impact of relative hypochromia in acute heart failure (AHF).

Methods: We prospectively characterized 1574 patients presenting with an adjudicated diagnosis of AHF to the emergency department. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01675273183541
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http://dx.doi.org/10.1016/j.ijcard.2019.02.060DOI Listing
February 2019
4 Reads

Prenatal manganese and cord blood mitochondrial DNA copy number: Effect modification by maternal anemic status.

Environ Int 2019 Mar 5;126:484-493. Epub 2019 Mar 5.

Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Introduction: Manganese (Mn) is an essential nutrient but also a toxicant at high exposures, when it can induce oxidative stress (OS). Mn uptake is inversely correlated with iron status, therefore anemic individuals may be more susceptible to Mn overload induced-OS, which can manifest as changes in mitochondrial DNA copy number (mtDNA CN). Our objectives were to: 1) determine stage-specific associations of prenatal Mn exposure with cord blood MtDNA CN; and 2) investigate effect modification by maternal anemia, ferritin, and mean corpuscular volume (MCV). Read More

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http://dx.doi.org/10.1016/j.envint.2019.02.029DOI Listing
March 2019
1 Read

Incident Anemia in Older Adults with Heart Failure Rate, Etiology, and Association with Outcomes.

Eur Heart J Qual Care Clin Outcomes 2019 Mar 7. Epub 2019 Mar 7.

Division of Research, Kaiser Permanente Northern California, Oakland, CA, USA.

Aims: Limited data exist on the epidemiology, evaluation, and prognosis of otherwise unexplained anemia of the elderly in HF. Thus, we aimed to determine the incidence of anemia, to characterize diagnostic testing patterns for potentially reversible causes of anemia, and to evaluate the independent association between incident anemia and long-term morbidity and mortality.

Methods And Results: Within the Cardiovascular Research Network (CVRN), we identified adults age ≥65 years with diagnosed HF between 2005-2012 and no anemia at entry. Read More

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http://fdslive.oup.com/www.oup.com/pdf/production_in_progres
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http://dx.doi.org/10.1093/ehjqcco/qcz010DOI Listing
March 2019
4 Reads

Iron deficiency anemia, population health and frailty in a modern Portuguese skeletal sample.

PLoS One 2019 7;14(3):e0213369. Epub 2019 Mar 7.

Department of Anthropology, California State University Sacramento, Sacramento, California, United States of America.

Introduction: Portugal underwent significant political, demographic and epidemiological transitions during the 20th century resulting in migration to urban areas with subsequent overcrowding and issues with water sanitation. This study investigates population health during these transitions and interprets results within a framework of recent history and present-day public health information. We investigate skeletal evidence for anemia (cribra orbitalia and porotic hyperostosis) as indicators of stress and frailty-i. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0213369PLOS
March 2019
3 Reads

Early gastric cancer with ball valve syndrome treated by endoscopic submucosal dissection.

Clin J Gastroenterol 2019 Mar 6. Epub 2019 Mar 6.

Department of Gastroenterology and Hepatology, Kurashiki Central Hospital, 1-1-1 Miwa, Kurashiki, Okayama, 710-8602, Japan.

An 84-year-old woman with pneumonia, congestive heart failure and chronic renal failure presented for iron-deficiency anemia and appetite loss. Esophagogastroduodenoscopy revealed a 60-mm sub-pedunculated tumor arising from the antrum of the stomach. The tumor was friable, with bleeding, and prolapsed into the duodenal bulb, the ball valve syndrome. Read More

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http://dx.doi.org/10.1007/s12328-019-00955-1DOI Listing
March 2019
2 Reads

Unusual Manifestation of Ulcerative Colitis.

Case Rep Pediatr 2019 31;2019:5163213. Epub 2019 Jan 31.

Pediatric Gastroenterology Division, Children's Hospital, King Fahad Medical City, Riyadh, Saudi Arabia.

The relationship of inflammatory bowel disease (IBD) and chronic recurrent multifocal osteomyelitis (CRMO) is understood as extraintestinal rheumatic manifestations. CRMO is a chronic, relapsing, inflammatory, noninfectious disorder of the skeletal system of unknown origin. The disease course is not always recurrent. Read More

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http://dx.doi.org/10.1155/2019/5163213DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374790PMC
January 2019
2 Reads

[Prevalence and sociodemographic factors associated with iron deficiency anemia in pregnant women of Colombia (secondary analysis of the ENSIN 2010)].

Nutr Hosp 2019 Mar;36(1):87-95

Fundación Universitaria del Área Andina.

Introduction: Objective: iron deficiency anemia is associated with adverse results for health and it is highly prevalent worldwide. The current study evaluated the prevalence and the sociodemographic factors associated with iron deficiency anemia in a sample of Colombian pregnant women. Materials and methods: the secondary analysis for the obtained information at the National Nutrition Survey (ENSIN) 2010 of Colombia in a probabilistic sample of 1,385 pregnant women between 13 and 49 years old. Read More

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https://www.nutricionhospitalaria.org/articles/01895/show
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http://dx.doi.org/10.20960/nh.1895DOI Listing
March 2019
4 Reads

Malignant Peritoneal Mesothelioma Without Asbestos Exposure.

Gastroenterology Res 2019 Feb 26;12(1):48-51. Epub 2019 Feb 26.

Department of Gastroenterology, Bronxcare Health System, Bronx, NY 10457, USA.

Malignant mesothelioma is a rare neoplasm of the serosal linings. Mesothelioma has been linked to asbestos exposure, with prior asbestos exposure linked to 33-50% of malignant peritoneal mesotheliomas. We describe a case of malignant peritoneal mesothelioma (MPM) without any prior exposure to asbestos in a 40-year-old Hispanic female who presented to the emergency department with worsening abdominal pain and distension. Read More

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http://dx.doi.org/10.14740/gr1141DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396791PMC
February 2019
1 Read

Serum ferritin, soluble transferrin receptor, and total body iron for the detection of iron deficiency in early pregnancy: a multiethnic population-based study with low use of iron supplements.

Am J Clin Nutr 2019 Mar;109(3):566-575

General Practice Research Unit (AFE), Department of General Practice, Institute of Health and Society, University of Oslo, Oslo, Norway.

Background: Which blood-based indicator best reflects the iron status in pregnant women is unclear. Better assessments of iron status in today's multiethnic populations are needed to optimize treatment and clinical recommendations.

Objectives: We aimed to determine the prevalence of anemia (hemoglobin <11. Read More

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https://academic.oup.com/ajcn/article/109/3/566/5369463
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http://dx.doi.org/10.1093/ajcn/nqy366DOI Listing
March 2019
4 Reads

The association between microcytic anemias and spirometric parameters.

Adv Respir Med 2019 Mar 4. Epub 2019 Mar 4.

Hormozgan University of Medical Sciences, Bandar Abbas, Iran, Iran, Islamic Republic Of.

Background Microcytic anemias are a group of anemias with smaller than normal red blood cells. Iron deficiency anemia and thalassemia are some of the major causes. The aim of this study was to compare the pulmonary function of the subjects with microcytic anemias to the normal population. Read More

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http://dx.doi.org/10.5603/ARM.a2019.0001DOI Listing

Patient Blood Management strategies for iron deficiency anemia management in gastric cancer.

Eur J Gastroenterol Hepatol 2019 04;31(4):547-548

Department of Surgery, University Hospital del Mar, Barcelona.

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http://dx.doi.org/10.1097/MEG.0000000000001383DOI Listing

Anemia Among School Children in Ernakulam District, Kerala, India.

Indian J Hematol Blood Transfus 2019 Jan 2;35(1):114-118. Epub 2018 Aug 2.

2Centre for Public Health, Amrita Institute of Medical Sciences, Amrita University, Kerala, India.

Anaemia has significant negative impact on the health of school children including poor scholastic performance and cognitive impairment. The present study was done with the objective to estimate the prevalence of anemia among school going children in Ernakulam district, Kerala and to determine a few factors associated with anemia. Hemoglobin of 880 students of 6th to 9th standard in 11 randomly selected schools of Ernakulam district was estimated using HemoCue 201 photometer. Read More

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http://dx.doi.org/10.1007/s12288-018-1001-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369096PMC
January 2019

The p.H63D allele of the HFE gene protects against low iron stores in Sri Lanka.

Blood Cells Mol Dis 2019 May 20;76:72-77. Epub 2019 Feb 20.

MRC Molecular Hematology Unit, MRC Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK.

In hereditary hemochromatosis, iron overload is associated with homozygosity for the p.C282Y mutation. A second mutation, p. Read More

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http://dx.doi.org/10.1016/j.bcmd.2019.02.004DOI Listing
May 2019
1 Read

[Heart failure and iron deficiency].

G Ital Cardiol (Rome) 2019 Mar;20(3):126-135

U.O. Scompenso e Cardiomiopatie, U.O.C. Cardiologia, Ospedale G. da Saliceto, AUSL Piacenza.

Heart failure with reduced ejection fraction (HFrEF) is a clinical reality with an incidence of >10% in the population over 65 years of age, expected to increase in the coming years. Alongside the well-known pharmacological options (e.g. Read More

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http://dx.doi.org/10.1714/3108.30962DOI Listing

The Spectrum of Small Intestinal Lesions in Patients with Unexplained Iron Deficiency Anemia Detected by Video Capsule Endoscopy.

Medicina (Kaunas) 2019 Feb 27;55(3). Epub 2019 Feb 27.

Section of Gastroenterology, Department of Emergency and Organ Transplantation, University of Bari, Piazza Giulio Cesare 11, 70124 Bari, Italy.

: Video-capsule endoscopy (VCE) has shown a large range (38⁻83%) of diagnostic yield in unexplained iron deficiency anemia (IDA) and obscure-occult bleeding. Therefore, we retrospectively investigated the VCE-detected spectrum and the prevalence of small bowel injuries and associated risk factors in inpatients with both of the above reported conditions. : We selected inpatients with IDA (hemoglobin <12 g/dL in women, <13 g/dL in men) and obscure-occult bleeding. Read More

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http://dx.doi.org/10.3390/medicina55030059DOI Listing
February 2019

Thiopurine Therapy for Inflammatory Bowel Disease During Pregnancy Is Not Associated with Anemia in the Infant.

Dig Dis Sci 2019 Feb 28. Epub 2019 Feb 28.

Digestive Diseases Institute, Shaare Zedek Medical Center, 12 Bayit St., 91031, Jerusalem, Israel.

Introduction: Thiopurine exposure throughout pregnancy in patients with inflammatory bowel diseases (IBD) is common and teratogenically safe. Late consequences of in utero exposure to thiopurines and its metabolite, 6-thioguanine nucleotides (6-TGN), such as neonatal and infant anemia are still disputed.

Aim: To evaluate whether 6-TGN exposure during pregnancy influences anemia in infants at 1 year of life. Read More

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http://dx.doi.org/10.1007/s10620-019-05555-0DOI Listing
February 2019
1 Read

Parenteral Versus Oral Iron for Treatment of Iron Deficiency Anaemia During Pregnancy and post-partum: A Systematic Review.

J Obstet Gynaecol India 2019 Feb 17;69(1):13-24. Epub 2019 Jan 17.

2All India Institute of Medical Sciences, Delhi, India.

Introduction: The burden of iron deficiency anaemia during pregnancy and post-partum continues to remain high especially in India. Challenges to treatment include gastrointestinal side effects and non compliance to oral iron therapy. Newer parenteral formulations need to be explored as alternatives. Read More

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http://dx.doi.org/10.1007/s13224-018-1191-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361181PMC
February 2019
1 Read

Arterioportal fistula after partial gastrectomy treated with coil embolisation.

BMJ Case Rep 2019 Feb 26;12(2). Epub 2019 Feb 26.

Internal Medicine, Hospital Beatriz Angelo, Loures, Lisboa, Portugal.

Arterioportal fistulas are a rare complication of abdominal interventions. They can remain asymptomatic for a long time and manifest with symptoms of portal hypertension. We present the case of a 65-year-old man admitted to the emergency room with increasing fatigue and melena. Read More

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http://dx.doi.org/10.1136/bcr-2018-226721DOI Listing
February 2019
1 Read

[Assessment of iron deficiency anemia management in the general hospital of Grenoble: A 12-month follow-up of an intravenous ferric carboxymaltose treatment program in a cohort of patients with non-dialysis-dependent chronic kidney disease].

Nephrol Ther 2019 Feb 22. Epub 2019 Feb 22.

Service de néphrologie, dialyses, aphérèses, transplantation rénale, CHU Grenoble-Alpes, CS 10 217, 38043 Grenoble cedex 9, France. Electronic address:

Introduction: The FIND-CKD study has validated the use of ferric carboxymaltose (FCM) injection with a target of ferritin level between 400 and 600ng/mL to treat iron deficiency anemia in non-dialysis-dependent chronic kidney disease (ND-CKD) patients. In order to assess this strategy in clinical practice, we constituted a cohort of patients within our nephrology department.

Patients And Methods: Patients had CKD stages 3 to 5, hemoglobin level (Hb)<13g/dL (men) or<12g/dL (women), and ferritin level (F)<100ng/mL or transferrin saturation (TSAT)<20%. Read More

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http://dx.doi.org/10.1016/j.nephro.2018.10.006DOI Listing
February 2019
2 Reads

Ferumoxytol for iron deficiency anemia in patients undergoing hemodialysis. The FACT randomized controlled trial
.

Clin Nephrol 2019 Feb 25. Epub 2019 Feb 25.

Background: Patients with chronic kidney disease (CKD) undergoing dialysis often require intravenous iron for iron deficiency anemia (IDA).

Materials And Methods: The Ferumoxytol for Anemia of CKD Trial (FACT), a randomized, multicenter, open-label, phase 4 study, compared the long-term safety and efficacy of ferumoxytol with iron sucrose for the treatment of IDA in patients with CKD undergoing hemodialysis. Patients with IDA and CKD undergoing hemodialysis were randomized 2:1 to ferumoxytol 1. Read More

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http://dx.doi.org/10.5414/CN109512DOI Listing
February 2019
1 Read

FeO@ Astragalus Polysaccharide Core-Shell Nanoparticles for Iron Deficiency Anemia Therapy and Magnetic Resonance Imaging in Vivo.

ACS Appl Mater Interfaces 2019 Mar 11. Epub 2019 Mar 11.

Department of Chemistry & Biochemistry , University of California , Santa Cruz , California 95064 , United States.

Iron deficiency anemia (IDA) is a common nutritional disease suffered by 1 billion people. To develop a new drug which avoids the side effects of traditional oral iron supplementation for IDA treatment, we have designed FeO@ Astragalus polysaccharide core-shell nanoparticles (FeO@APS NPs) and demonstrated them to be an efficient therapeutic drug for IDA treatment in vivo. The FeO@APS NPs have been successfully synthesized with good water solubility and stability, especially in imitated digestion. Read More

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http://dx.doi.org/10.1021/acsami.8b18648DOI Listing
March 2019
2 Reads

Hepcidin and the BMP-SMAD pathway: An unexpected liaison.

Vitam Horm 2019 10;110:71-99. Epub 2019 Feb 10.

Regulation of Iron Metabolism Unit, Division of Genetics and Cell Biology, IRCCS San Raffaele Scientific Institute, Milano, Italy.

Hepcidin, the main regulator of iron metabolism, is synthesized and released by hepatocytes in response to increased body iron concentration and inflammation. Deregulation of hepcidin expression is a common feature of genetic and acquired iron disorders: in Hereditary Hemochromatosis (HH) and iron-loading anemias low hepcidin causes iron overload, while in Iron Refractory Iron Deficiency Anemia (IRIDA) and anemia of inflammation (AI), high hepcidin levels induce iron-restricted erythropoiesis. Hepcidin expression in the liver is mainly controlled by the BMP-SMAD pathway, activated in a paracrine manner by BMP2 and BMP6 produced by liver sinusoidal endothelial cells. Read More

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http://dx.doi.org/10.1016/bs.vh.2019.01.004DOI Listing
February 2019
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Hepcidin in chronic kidney disease anemia.

Vitam Horm 2019 6;110:243-264. Epub 2019 Feb 6.

UCIBIO\REQUIMTE, Laboratory of Biochemistry, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal.

Chronic kidney disease (CKD) is associated with several complications that worsen with progression of disease; anemia, disturbances in iron metabolism and inflammation are common features. Inflammatory response starts early, releasing pro-inflammatory cytokines, acute phase reactants and hepcidin. Hepcidin production is modulated by several factors, as hypoxia/anemia, erythropoietin and erythropoiesis products, transferrin saturation (TSAT) and liver iron levels, which are altered in CKD. Read More

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http://dx.doi.org/10.1016/bs.vh.2019.01.012DOI Listing
February 2019
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Hepcidin-ferroportin axis in health and disease.

Vitam Horm 2019 8;110:17-45. Epub 2019 Feb 8.

Tisch Cancer Institute, Division of Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, NY, United States. Electronic address:

Hepcidin is central to regulation of iron metabolism. Its effect on a cellular level involves binding ferroportin, the main iron export protein, resulting in its internalization and degradation and leading to iron sequestration within ferroportin-expressing cells. Aberrantly increased hepcidin leads to systemic iron deficiency and/or iron restricted erythropoiesis. Read More

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http://dx.doi.org/10.1016/bs.vh.2019.01.002DOI Listing
February 2019
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Regulators of hepcidin expression.

Vitam Horm 2019 2;110:101-129. Epub 2019 Feb 2.

Institut de Recherche en Santé Digestive (IRSD), Université de Toulouse, INSERM, INRA, ENVT, UPS, Toulouse, France.

Iron, an essential nutrient, is required for many biological processes but is also toxic in excess. The lack of a mechanism to excrete excess iron makes it crucial for the body to regulate the amount of iron absorbed from the diet. This regulation is mediated by the hepatic hormone hepcidin. Read More

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http://dx.doi.org/10.1016/bs.vh.2019.01.005DOI Listing
February 2019
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The effect of therapy on plasma ghrelin and leptin levels, and appetite in children with iron deficiency anemia.

J Pediatr Endocrinol Metab 2019 Mar;32(3):275-280

Faculty of Medicine, Department of Biochemistry, Atatürk University, Erzurum, Turkey.

Background It is known that iron deficiency anemia effects appetite and growth negatively. The aim of this study was to investigate the effect of iron therapy on appetite, growth and plasma ghrelin and leptin levels in children aged between 12 and 24 months with isolated nutritional iron deficiency anemia. Methods Iron deficiency anemia was diagnosed by clinic and laboratory findings. Read More

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http://dx.doi.org/10.1515/jpem-2018-0352DOI Listing
March 2019
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A Cross-Sectional Study on Malnutrition in Inflammatory Bowel Disease: Is There a Difference Based on Pediatric or Adult Age Grouping?

Inflamm Bowel Dis 2019 Feb 22. Epub 2019 Feb 22.

IBD Research Group, McGill University Health Center, Montreal, Quebec, Canada; Research Centre, Sainte-Justine UHC.

Background: Malnutrition, commonly observed in inflammatory bowel disease (IBD), is associated with increased morbidity and mortality and is attributed to multiple causes. The added energy costs of growth in the child and adolescent with IBD are an additional risk factor.

Methods: The aim of the study was to perform a cross-sectional comparison of nutritional parameters in IBD between pediatric and adult cases. Read More

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http://dx.doi.org/10.1093/ibd/izy403DOI Listing
February 2019
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An update on the evaluation and management of iron deficiency anemia in inflammatory bowel disease.

Expert Rev Gastroenterol Hepatol 2019 Feb 7;13(2):95-97. Epub 2018 Dec 7.

a Crohn Colitis Clinical Research Centre Rhein-Main , Frankfurt am Main , Germany.

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https://www.tandfonline.com/doi/full/10.1080/17474124.2019.1
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http://dx.doi.org/10.1080/17474124.2019.1553618DOI Listing
February 2019
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A systematic literature review of the relation between iron status/anemia in pregnancy and offspring neurodevelopment.

Eur J Clin Nutr 2019 Feb 19. Epub 2019 Feb 19.

The Research Unit for Dietary Studies at The Parker Institute, Bispebjerg and Frederiksberg Hospital, part of the Copenhagen University Hospital, The Capital Region, Copenhagen, Denmark.

Background: The fetal brain starts developing early and animal studies have suggested that iron plays several roles for the development, but results from epidemiological studies investigating associations between gestational iron and offspring neurodevelopment are inconsistent.

Objective: To systematically examine results from observational studies and RCTs on gestational iron and offspring neurodevelopment, with focus on the importance of four domains: iron status indicators, exposure timing, neurodevelopmental outcomes, and offspring age.

Methods: PRISMA guidelines were followed. Read More

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http://dx.doi.org/10.1038/s41430-019-0400-6DOI Listing
February 2019
2 Reads