18,794 results match your criteria Iron Deficiency Anemia


Effect of small-quantity lipid-based nutrient supplements on growth, psychomotor development, iron status, and morbidity among 6- to 12-mo-old infants in South Africa: a randomized controlled trial.

Am J Clin Nutr 2019 Jan 15. Epub 2019 Jan 15.

Center of Excellence for Nutrition, North-West University, Potchefstroom, South Africa.

Background: Evidence on the effect of small-quantity lipid-based nutrient supplements (SQ-LNSs) on early child growth and development is mixed.

Objective: This study assessed the effect of daily consumption of 2 different SQ-LNS formulations on linear growth (primary outcome), psychomotor development, iron status (secondary outcomes), and morbidity in infants from age 6 to 12 mo within the context of a maize-based complementary diet.

Methods: Infants (n = 750) were randomly assigned to receive SQ-LNS, SQ-LNS-plus, or no supplement. Read More

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http://dx.doi.org/10.1093/ajcn/nqy282DOI Listing
January 2019

Effect of iron deficiency anemia on HbA1c in diabetic patients at Tikur Anbessa specialized teaching hospital, Addis Ababa Ethiopia.

BMC Hematol 2019 9;19. Epub 2019 Jan 9.

1College of Medicine and Health Sciences Department of Medical Laboratory Sciences, Wolkite University, Wolkite, Ethiopia.

Background: Hemoglobin A1C (HbA1c) is the predominant hemoglobin found in HbA1 fractions. A1c assay is the recommended assay for diagnosing diabetes and any condition that changes red cell turnover such as Iron deficiency Anemia (IDA), will lead to spurious A1C results. Therefore, the present study was aimed at determining the effect of IDA on HbA1c in diabetic patients attending Black Lion Specialized Teaching Hospital, Addis Ababa, Ethiopia. Read More

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http://dx.doi.org/10.1186/s12878-018-0132-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327502PMC
January 2019

Associations between iron deficiency anemia and clinical features among pregnant women: a prospective cohort study [Retraction].

Authors:

J Blood Med 2019 27;10:19. Epub 2018 Dec 27.

[This retracts the article on p. 163 in vol. 9, PMID: 30323700. Read More

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http://dx.doi.org/10.2147/JBM.S198516DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312047PMC
December 2018

Distinguishing iron deficiency anemia from thalassemia by the red blood cell lifespan with a simple CO breath test: A pilot study.

J Breath Res 2019 Jan 14. Epub 2019 Jan 14.

Haikou Municipal People's Hospital, Affiliated Haikou Hospital Xiangya School of Medicine Central South University, Haikou, CHINA.

Background: Extant indices for distinguishing between iron deficiency anemia (IDA) and thalassemia (Thal) have substantial practical limitations. The aim of this pilot study was to assess the predictive value of red blood cell lifespan (RBCLS), as determined by an automated CO breath test analysis approach, in the differential diagnosis of these two common forms of microcytic hypochromic anemia (MHA). Methods: RBCLS measurements were conducted in 35 healthy controls (HCs) and 114 patients diagnosed with MHA (IDA, N = 59; and Thal, N = 55) with ELS TESTER that provides a direct RBCLS value read-out. Read More

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http://dx.doi.org/10.1088/1752-7163/aafe4fDOI Listing
January 2019

Anemia in Patients with Diabetic Foot Ulcer: Effects on Diabetic Microvascular Complications and Related Conditions.

Endocr Metab Immune Disord Drug Targets 2019 Jan 11. Epub 2019 Jan 11.

Cukurova University Faculty of Medicine, Department of Internal Medicine, Division of Endocrinology, Adana. Turkey.

Objective: We aimed to investigate the etiology and prevalence of anemia in patients with diabetic foot ulcers and the relationship between both microvascular complications and related conditions and anemia.

Method: We retrospectively collected and evaluated the data of 225 patients with diabetic foot ulcer followed at our clinic. The demographic characteristics of the patients were analyzed. Read More

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http://www.eurekaselect.com/168896/article
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http://dx.doi.org/10.2174/1871530319666190111121913DOI Listing
January 2019
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The opposing effects of acute inflammation and iron deficiency anemia on serum hepcidin and iron absorption in young women.

Haematologica 2019 Jan 10. Epub 2019 Jan 10.

Laboratory of Human Nutrition, ETH Zürich.

Hepatic hepcidin synthesis is stimulated by inflammation but inhibited during iron deficiency anemia. In humans, the relative strength of these opposing signals on serum hepcidin and the net effect on iron absorption and systemic iron recycling is uncertain. In this prospective, 45-day study, in young women (n=46; age 18-49 y) with or without iron deficiency anemia, we compared iron and inflammation markers, serum hepcidin and erythrocyte iron incorporation from 57Fe-labeled test meals, before and 8, 24 and 36 hours after influenza/DPT vaccination as an acute inflammatory stimulus. Read More

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http://dx.doi.org/10.3324/haematol.2018.208645DOI Listing
January 2019

Independent Predictors of Adverse Cardiovascular Events in Patients With Acute Coronary Syndrome After Percutaneous Coronary Intervention During Hospitalization.

Kardiologiia 2018 Dec 25;58(12):22-29. Epub 2018 Dec 25.

Semey State Medical University.

Purpose: to elucidate independent clinical and laboratory predictors of adverse cardiovascular events (ACVE) in patients with acute coronary syndrome (ACS) after percutaneous coronary intervention (PCI) with stenting in early inhospital period.

Materials And Methods: We included in this prospective single center study 130 patients with ACS who underwent PCI with stenting. All patients prior to and after PCI received dual antiplatelet therapy with acetylsalicylic acid and clopidogrel. Read More

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http://dx.doi.org/10.18087/cardio.2018.12.10205DOI Listing
December 2018
1 Read

Utility of new red cell parameters for distinguishing functional iron deficiency from absolute iron deficiency in children with familial Mediterranean fever.

Int J Lab Hematol 2019 Jan 9. Epub 2019 Jan 9.

Department of Pediatric Rheumatology and Nephrology, Faculty of Medicine, Gazi University, Ankara, Turkey.

Introduction: Few data are available on the clinical utility of new red cell parameters for detecting anemia in children with inflammatory diseases. The aim was to investigate the utility of three new red cell parameters for distinguishing functional iron deficiency (FID) from absolute iron deficiency (AID) in children with familial Mediterranean fever (FMF).

Methods: The study involved 198 children with genetically confirmed FMF and 18 healthy-age and sex-matched controls. Read More

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http://doi.wiley.com/10.1111/ijlh.12971
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http://dx.doi.org/10.1111/ijlh.12971DOI Listing
January 2019
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Maternal and Infant Supplementation with Small-Quantity Lipid-Based Nutrient Supplements Increases Infants' Iron Status at 18 Months of Age in a Semiurban Setting in Ghana: A Secondary Outcome Analysis of the iLiNS-DYAD Randomized Controlled Trial.

J Nutr 2019 Jan 8. Epub 2019 Jan 8.

Program in International and Community Nutrition, Department of Nutrition, University of California, Davis, CA.

Background: Interventions are needed to address iron deficiency in low-income settings.

Objective: This secondary outcome analysis aimed to compare the hemoglobin (Hb) and iron status [zinc protoporphyrin (ZPP)] of children born to women enrolled in the iLiNS-DYAD trial in Ghana.

Methods: Women ≤20 wk pregnant (n = 1320) were assigned to receive 60 mg Fe/d and 400 µg folic acid/d until delivery and placebo thereafter, and no supplementation for infants (IFA group); or multiple micronutrients containing 20 mg Fe/d until 6 mo postpartum and no supplementation for infants (MMN); or small-quantity lipid-based nutrient supplements (SQ-LNSs) containing 20 mg Fe/d until 6 mo postpartum, and SQ-LNSs for infants from 6 to 18 mo of age (LNS). Read More

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http://dx.doi.org/10.1093/jn/nxy225DOI Listing
January 2019
1 Read

Effects of lipid-based nutrient supplements and infant and young child feeding counseling with or without improved water, sanitation, and hygiene (WASH) on anemia and micronutrient status: results from 2 cluster-randomized trials in Kenya and Bangladesh.

Am J Clin Nutr 2019 Jan 9. Epub 2019 Jan 9.

Innovations for Poverty Action, Nairobi, Kenya.

Background: Anemia in young children is a global health problem. Risk factors include poor nutrient intake and poor water quality, sanitation, or hygiene.

Objective: We evaluated the effects of water quality, sanitation, handwashing, and nutrition interventions on micronutrient status and anemia among children in rural Kenya and Bangladesh. Read More

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http://dx.doi.org/10.1093/ajcn/nqy239DOI Listing
January 2019

Mucosal miR-3677 is over-expressed in cirrhotic patients with gastric antral vascular ectasia (GAVE).

Scand J Gastroenterol 2019 Jan 8:1-6. Epub 2019 Jan 8.

a Department of Gastroenterology and Hepatology , School of Medicine in Katowice, Medical University of Silesia , Katowice , Poland.

Introduction: Gastric antral vascular ectasia (GAVE) is a rare vasculopathy that associates several diseases, most commonly liver cirrhosis. It usually presents as an occult gastrointestinal bleeding leading to profound iron deficiency anemia. We hypothesized that GAVE is local mucosal pathology dependent on genetic mechanisms, and the purpose of the study was to characterize miRNAs expression in gastric tissue of patients with cirrhosis and GAVE. Read More

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https://www.tandfonline.com/doi/full/10.1080/00365521.2018.1
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http://dx.doi.org/10.1080/00365521.2018.1547922DOI Listing
January 2019
1 Read

Risk of adverse events in patients prescribed long-term opioids: a cohort study in the UK Clinical Practice Research Datalink.

Eur J Pain 2019 Jan 8. Epub 2019 Jan 8.

Arthritis Research UK Primary Care Centre, Research Institute for Primary Care & Health Sciences, Keele University, Staffordshire, ST5 5BG.

Background: Long-term opioid prescribing for musculoskeletal pain is controversial due to uncertainty regarding effectiveness and safety. This study examined the risks of a range of adverse events in a large cohort of patients prescribed long-term opioids using the UK Clinical Practice Research Datalink.

Methods: Patients with musculoskeletal conditions starting a new long-term opioid episode (defined as ≥3 opioid prescriptions within 90 days) between 2002-2012 were included. Read More

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http://doi.wiley.com/10.1002/ejp.1357
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http://dx.doi.org/10.1002/ejp.1357DOI Listing
January 2019
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Treatment of iron deficiency in patients with chronic kidney disease: A prospective observational study of iron isomaltoside (NIMO Scandinavia)
.

Clin Nephrol 2019 01 7. Epub 2019 Jan 7.

Aims: Iron deficiency is common in patients with chronic kidney disease (CKD). Appropriate iron substitution is critical and intravenous iron is an established therapy for these patients. The objective of this study was to assess treatment routine, -effectiveness, and safety of iron isomaltoside (Monofer®, Pharma-cosmos A/S, Holbaek, Denmark) in CKD patients in clinical practice. Read More

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http://dx.doi.org/10.5414/CN109474DOI Listing
January 2019

Heme-bound iron in treatment of pregnancy-associated iron deficiency anemia.

J Family Med Prim Care 2018 Nov-Dec;7(6):1434-1438

Department of Obstetrics and Gynecology, Alwakra Hospital, Hamad Medical Corporation, Qatar.

Background: The iron requirements increase during the second and third trimesters of pregnancy. Maternal anemia is a leading cause of adverse perinatal outcome.

Objectives: This study was designed to evaluate the efficacy of the heme-bound iron in treatment of pregnancy-associated iron deficiency anemia (IDA). Read More

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http://dx.doi.org/10.4103/jfmpc.jfmpc_271_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6293905PMC
January 2019

Comparative efficacy of two parenteral iron-containing preparations, iron gleptoferron and iron dextran, for the prevention of anaemia in suckling piglets.

Vet Rec Open 2018 5;5(1):e000317. Epub 2018 Dec 5.

Department of Pathobiology, Institute of Parasitology, University of Veterinary Medicine Vienna, Vienna, Austria.

Iron-deficiency anaemia (IDA) is a serious health problem in neonatal piglets and is controlled by routine application of iron in various formulations. The efficacy and safety of two iron-containing products for the prevention of IDA in suckling piglets were compared in a randomised, parallel study. Newborn piglets were treated with 200 mg iron supplied by intramuscular injection in the neck as either Forceris (gleptoferron; n=13) or Uniferon 200 (iron dextran; n=12) 24-48 hours after birth. Read More

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http://vetrecordopen.bmj.com/lookup/doi/10.1136/vetreco-2018
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http://dx.doi.org/10.1136/vetreco-2018-000317DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307558PMC
December 2018
1 Read

Initial outcomes of one anastomosis gastric bypass at a single institution.

Diabetes Metab Syndr Obes 2019 24;12:35-41. Epub 2018 Dec 24.

Department of Surgery, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia,

Introduction: One anastomosis gastric bypass (OAGB) is an emerging bariatric procedure, which has been reported to be safe and effective. This study aims to evaluate the short-term outcome of OAGB and its midterm effects on weight loss and remission of type 2 diabetes mellitus (T2DM).

Materials And Methods: A retrospective review of patients who had undergone OAGB between January 2013 and January 2017 in King Abdulaziz University Hospital, Jeddah, Saudi Arabia, is presented here. Read More

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https://www.dovepress.com/initial-outcomes-of-one-anastomosi
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http://dx.doi.org/10.2147/DMSO.S180111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307494PMC
December 2018
1 Read

Silencing of circ_0009910 inhibits acute myeloid leukemia cell growth through increasing miR-20a-5p.

Blood Cells Mol Dis 2018 Dec 28;75:41-47. Epub 2018 Dec 28.

Laboratory of Hematology, Hunan Provincial People's Hospital, The First-Affiliated Hospital of Hunan Normal University, Changsha 410002, Hunan Province, China. Electronic address:

Acute myeloid leukemia (AML) is the most common acute leukemia in adults, which is aggressive cancer. CircRNAs are abundantly expressed in the hematologic malignancy cells. In this study, we aimed to investigate the expression profiling of circRNAs in AML. Read More

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http://dx.doi.org/10.1016/j.bcmd.2018.12.006DOI Listing
December 2018

Kyphoscoliosis with Klippel-Trenaunay syndrome: a case report and literature review.

BMC Musculoskelet Disord 2019 Jan 5;20(1):10. Epub 2019 Jan 5.

Department of Orthopaedic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, 100730, China.

Background: Klippel-Trenaunay syndrome (KTS) is a rare congenital syndrome characterized by the triad of venous varicosities, capillary malformations and limb hypertrophy. However, KTS may rarely occur in combination with kyphoscoliosis.

Case Presentation: We presented an 18-year-old female with KTS and kyphoscoliosis. Read More

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https://bmcmusculoskeletdisord.biomedcentral.com/articles/10
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http://dx.doi.org/10.1186/s12891-018-2393-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320630PMC
January 2019
5 Reads

Society for the Advancement of Blood Management Administrative and Clinical Standards for Patient Blood Management Programs. 4 Edition (Pediatric Version).

Paediatr Anaesth 2019 Jan 4. Epub 2019 Jan 4.

Department of Anesthesiology and Bloodless Medicine, Englewood Hospital and Medical Center, NJ, USA.

Patient Blood Management is the timely application of evidence-based medical and surgical concepts designed to maintain hemoglobin concentration, optimize hemostasis and minimize blood loss to improve patient outcomes. Conceptually similar to a "bundle" strategy, it is designed to improve clinical care by using comprehensive evidence-based treatment strategies to manage patients with potential or ongoing critical bleeding, bleeding diathesis, critical anemia and/ or a coagulopathy. Patient Blood Management includes multimodal strategies to screen, diagnose and properly treat anemia, coagulopathies and minimize bleeding, using goal-directed therapy and leverages a patient's physiologic ability to adapt to anemia while definitive treatment is undertaken. Read More

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http://dx.doi.org/10.1111/pan.13574DOI Listing
January 2019
6 Reads

Obstetric and Neonatal Outcomes of Pregnant Indian Pilgrims: A three-year experience at the Indian Hajj Medical Mission.

Sultan Qaboos Univ Med J 2018 Aug 19;18(3):e355-e361. Epub 2018 Dec 19.

Department of Clinical Microbiology & Infectious Diseases, Army College of Medical Sciences & Base Hospital, New Delhi, India.

Objectives: The , an annual mass gathering of Muslim pilgrims, is known for its high morbidity and mortality rates. However, pregnant women sometimes participate in this pilgrimage, despite guidelines that discourage such an undertaking due to potential fetomaternal complications. This study aimed to evaluate fetomaternal outcomes among pregnant Indian pilgrims. Read More

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http://dx.doi.org/10.18295/squmj.2018.18.03.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307628PMC
August 2018
1 Read

The role of haematological indices in predicting early iron deficiency among pregnant women in an urban area of Sri Lanka.

BMC Hematol 2018 22;18:37. Epub 2018 Dec 22.

1Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka.

Background: Early detection and treatment of iron deficiency during pregnancy is crucial for optimum pregnancy outcomes. Anaemia is a late indictor of iron deficiency measured as Hb < 11 g/dL, and is widely used as a proxy for iron deficiency. We aimed to evaluate the role of red cell indices as a screening tool for early detection of iron deficiency among pregnant women in an urban area of Sri Lanka. Read More

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http://dx.doi.org/10.1186/s12878-018-0131-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303966PMC
December 2018
1 Read

Glycosylated Hemoglobin in Subjects Affected by Iron-Deficiency Anemia.

Diabetes Metab J 2018 Nov 28. Epub 2018 Nov 28.

Department of Laboratory Medicine, Desio Hospital, University of Milano-Bicocca, Desio, Italy.

Previous studies have suggested that iron-deficiency anemia affects glycosylated hemoglobin (HbA1c) measurements, but the results were contradictory. We conducted a retrospective case-control study to determine the effects of iron deficiency on HbA1c levels. Starting with the large computerized database of the Italian Hospital of Desio, including data from 2000 to 2016, all non-pregnant individuals older than 12 years of age with at least one measurement of HbA1c, cell blood count, ferritin, and fasting blood glucose on the same date of blood collection were enrolled. Read More

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http://dx.doi.org/10.4093/dmj.2018.0072DOI Listing
November 2018
1 Read

The impact of a planned health educational program on the compliance and knowledge of Jordanian pregnant women with anemia.

Women Health 2018 Dec 31:1-12. Epub 2018 Dec 31.

c Department of Nursing , Al-Hussein Bin Talal University , Ma'an , Jordan.

Iron deficiency anemia is a major public health problem among pregnant women in developing countries. This study aimed to use a randomized controlled trial to evaluate the effectiveness of a health information package in Jordanian anemic pregnant women's knowledge regarding anemia, compliance with iron supplementation, and hemoglobin level. Two hundred pregnant anemic women were recruited and randomly assigned into intervention or control group from April to July 2016. Read More

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http://dx.doi.org/10.1080/03630242.2018.1549644DOI Listing
December 2018

Prevalence, risk factors, and significance of iron deficiency and anemia in nonischemic heart failure patients with reduced ejection fraction from a Himachal Pradesh heart failure registry.

Indian Heart J 2018 Dec 2;70 Suppl 3:S182-S188. Epub 2018 Nov 2.

IGMC Shimla, HP, India.

Background: The study aimed to estimate the prevalence, risk determinants, and its clinical significance of iron deficiency and anemia in patients of nonischemic heart failure with reduced ejection fraction (HFrEF).

Methods: Serum ferritin, transferrin saturation, and the hemoglobin (Hb) levels were measured in 226 consecutive patients with HFrEF diagnosed based on the left ventricular ejection fraction ≤ 45% and absence of coronary artery luminal narrowing of more than 50%, in a prospective tertiary care hospital-based heart failure registry. Patients with the New York Heart Association functional class III/IV were classified as patients with advanced heart failure. Read More

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http://dx.doi.org/10.1016/j.ihj.2018.10.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310070PMC
December 2018

Anemia profile in patients with congestive heart failure a hospital based observational study.

Indian Heart J 2018 Dec 30;70 Suppl 3:S101-S104. Epub 2018 Jun 30.

Department of Cardiology, Sir Ganga Ram Hospital, New Delhi 110060, India.

Objectives: Iron deficiency (ID) is an emerging problem in patients with congestive heart failure (CHF) and can be a potential therapeutic target. As ID is highly prevalent in the society, it is hypothesized that Indian patients with CHF have high prevalence of ID.

Methods: CHF patients (n = 275) were selected and underwent laboratory evaluation including hemoglobin concentration, serum iron, transferrin, ferritin, B12 and folate level. Read More

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http://dx.doi.org/10.1016/j.ihj.2018.06.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309281PMC
December 2018

Favourable improvement in haematological parameters in response to oral iron and vitamin C combination in children with Iron Refractory Iron Deficiency Anemia (IRIDA) phenotype.

Blood Cells Mol Dis 2018 Dec 13;75:26-29. Epub 2018 Dec 13.

Pediatric Hematology Oncology Unit, Department of Pediatrics, Post Graduate Institute of Medical Education and Research, Chandigarh 160012, India.

Treatment in IRIDA focuses on use of intravenous iron preparations to circumvent oral absorptive defect resulting from high levels of hepcidin due to TMPRSS6 gene variations. However, recent case reports and recommendations on atypical microcytic hypochromic anemias advocate use of oral iron and vitamin c trial before parenteral iron, as the same results in comparable improvement in haemoglobin. We prospectively evaluated our IRIDA cohort (n = 7) with oral iron and vitamin c dose over a period of 10 weeks and noted complete response in majority (6/7 = 86%) with >2 g/dL rise in Hb along with significant improvement of other iron related indices. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10799796183041
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http://dx.doi.org/10.1016/j.bcmd.2018.12.002DOI Listing
December 2018
2 Reads

Reticulocyte hemoglobin equivalent (Ret-He) in a thalassemia-prevalent area.

Pediatr Int 2018 Dec 29. Epub 2018 Dec 29.

Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, 270 Rama VI Road, Ratchathewi District, Bangkok, 10400, Thailand.

Introduction: Reticulocyte hemoglobin equivalent (Ret-He), a direct measure of the hemoglobin in the young RBC, has been reported to be useful in the diagnosis of iron deficiency anemia (IDA) but may have some limitations in thalassemia trait. This study aims to evaluate the differences of Ret-He levels in a population of school-aged children and to assess the diagnostic value of Ret-He in identifying IDA in a thalassemia-prevalent area.

Methods: Blood samples from subjects were tested for CBC including Ret-He, ferritin, serum iron and total iron binding capacity. Read More

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http://doi.wiley.com/10.1111/ped.13775
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http://dx.doi.org/10.1111/ped.13775DOI Listing
December 2018
4 Reads

Assessment of iron status in predialysis chronic kidney disease patients in a Nigerian Tertiary Hospital.

Saudi J Kidney Dis Transpl 2018 Nov-Dec;29(6):1431-1440

Department of Internal Medicine, University of Benin, Benin City, Edo State, Nigeria.

Anemia in chronic kidney disease (CKD) is associated with poor overall outcome if not promptly managed with erythropoietin when indicated. This study assessed iron status and associated factors in predialysis CKD patients in Southern Nigeria. This was a cross-sectional study that assessed and compared iron status in 100 predialysis CKD patients and 90 healthy controls. Read More

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http://dx.doi.org/10.4103/1319-2442.248296DOI Listing
December 2018

Assessment of iron deficiency anaemia and its risk factors among adults with chronic kidney disease in a tertiary hospital in Nigeria.

Niger Postgrad Med J 2018 Oct-Dec;25(4):197-203

Department of Medicine, College of Medicine, University of Ibadan, Ibadan, Oyo State; Department of Clinical Sciences, Nigerian Institute of Medical Research, Yaba, Lagos, Nigeria.

Introduction: A substantial proportion of patients with chronic kidney disease (CKD) develop iron deficiency anaemia (IDA). Despite the association of IDA with adverse cardiovascular outcomes, it remains underdiagnosed and poorly managed. Up to 70% of patients with CKD are anaemic at the time of initiating dialysis, while the predictors of IDA in these patients in our setting are unknown. Read More

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http://dx.doi.org/10.4103/npmj.npmj_106_18DOI Listing
December 2018

Problems in Ferrokinetics: extra radio-iron fixation to red cells.

Authors:
Hiroshi Saito

Nagoya J Med Sci 2018 Nov;80(4):475-485

Department of Internal Medicine, Kawamura Hospital, 1-84 Daihannya, Akutami, Gifu, Japan.

Red cell radio-iron utilization (RCU) exceeds the ratio red cell iron per whole-body iron due to the extra red cell fixation of radio-iron refluxed from tissue. The extra red cell radio-iron fixation reduces the radio-iron distribution to non-erythron tissue. Affected by RCU, the red cell iron turnover rate (RCIT) becomes larger than the net red cell iron turnover rate, which is indicated by the red cell iron renewal rate (RCIR). Read More

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http://dx.doi.org/10.18999/nagjms.80.4.475DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295426PMC
November 2018
1 Read

Pregnancy after bariatric surgery: a narrative literature review and discussion of impact on pregnancy management and outcome.

BMC Pregnancy Childbirth 2018 Dec 27;18(1):507. Epub 2018 Dec 27.

Department of Obstetrics and Gynecology, Division of Obstetrics and Feto-maternal Medicine, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria.

Bariatric surgery (BS) is regarded to be the most effective treatment of obesity with long lasting beneficial effects including weight loss and improvement of metabolic disorders. A considerable number of women undergoing BS are at childbearing age.Although the surgery mediated weight loss has a positive effect on pregnancy outcome, the procedures might be associated with adverse outcomes as well, for example micronutrient deficiencies, iron or B12 deficiency anemia, dumping syndrome, surgical complications such as internal hernias, and small for gestational age (SGA) offspring, possibly due to maternal undernutrition. Read More

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http://dx.doi.org/10.1186/s12884-018-2124-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307154PMC
December 2018
1 Read

Structure characterization of low molecular weight sulfate Ulva polysaccharide and the effect of its derivative on iron deficiency anemia.

Int J Biol Macromol 2018 Dec 22;126:747-754. Epub 2018 Dec 22.

College of Food Science and Engineering, Ocean University of China, Qingdao 266003, PR China. Electronic address:

Sulfate Ulva polysaccharide with low molecular weight was prepared by enzymatic method and name SUE. The structural characterization of SUE and the effect of its derivative SUE-iron (III) on iron deficiency anemia were studied. Results showed SUE with molecular weight of 178 kDa were consisted of 57. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2018.12.214DOI Listing
December 2018
2 Reads

Serum Concentration of Hepcidin as an Indicator of Iron Reserves in Children.

J Med Biochem 2018 Dec 1;37(4):456-464. Epub 2018 Dec 1.

Institute of Food Technology, University of Novi Sad, Novi Sad, Serbia.

Background: Anemia represents a significant cause of maternal and perinatal mortality, as well as child mortality. The aim of the research was to determine the serum concentration of hepcidin in children aged 6 months to 2 years and adolescents aged 11 to 19 years which suffer from iron deficiency anemia and compare it with the serum concentration of hepcidin in the control groups, as well as to determine its connection with the parameters of the iron metabolism.

Methods: The research included 173 examinees, 89 of them suffered from iron deficiency anemia and 84 did not suffer from iron deficiency anemia (the latter represented the control group). Read More

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http://content.sciendo.com/view/journals/jomb/37/4/article-p
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http://dx.doi.org/10.2478/jomb-2018-0003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298481PMC
December 2018
3 Reads

Anemia, hematinic deficiencies, and hyperhomocysteinemia in gastric parietal cell antibody-positive and -negative atrophic glossitis patients.

J Formos Med Assoc 2018 Dec 20. Epub 2018 Dec 20.

Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan. Electronic address:

Background/purpose: Approximately 27% of atrophic glossitis (AG) patients have the serum gastric parietal cell antibody (GPCA) positivity. This study assessed whether the serum GPCA or AG itself was a significant factor causing anemia, hematinic deficiencies, and hyperhomocysteinemia in GPCA-positive AG (GPCAAG) and GPCA-negative AG (GPCAAG) patients.

Methods: The mean corpuscular volume (MCV) and mean blood hemoglobin (Hb), iron, vitamin B12, folic acid, and homocysteine levels were measured and compared between any two of three groups of 284 GPCAAG, 780 GPCAAG patients, and 532 healthy control subjects. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09296646183080
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http://dx.doi.org/10.1016/j.jfma.2018.12.005DOI Listing
December 2018
4 Reads

Effects of Daily Zinc, Daily Multiple Micronutrient Powder, or Therapeutic Zinc Supplementation for Diarrhea Prevention on Physical Growth, Anemia, and Micronutrient Status in Rural Laotian Children: A Randomized Controlled Trial.

J Pediatr 2018 Dec 21. Epub 2018 Dec 21.

Program in International and Community Nutrition, Department of Nutrition, University of California, Davis, CA.

Objectives: To evaluate the optimal zinc supplementation strategy for improving growth and hematologic and micronutrient status in young Laotian children.

Study Design: In total, 3407 children aged 6-23 months were randomized to receive either daily preventive zinc tablets (7 mg/d), high-zinc, low-iron micronutrient powder (10 mg/d zinc, 6 mg/d iron, and 13 other micronutrients), therapeutic zinc supplementation for diarrhea (20 mg/d for 10 days per episode), or daily placebo powder; all were followed for ~9 months. Anthropometry, hemoglobin, zinc, and iron status were assessed at baseline and endline. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00223476183161
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http://dx.doi.org/10.1016/j.jpeds.2018.11.022DOI Listing
December 2018
4 Reads

Auditory brainstem response in infants with iron deficiency anemia.

Int J Pediatr Otorhinolaryngol 2019 Feb 14;117:78-81. Epub 2018 Nov 14.

Department of Speech, Language and Hearing Sciences, Sri Ramachandra Institute of Higher Education and Research (Deemed to Be University), Chennai, 600 116, India. Electronic address:

Background: Auditory brainstem response (ABR) in infants with Iron Deficiency Anemia (IDA) helps in understanding the auditory aspects of central nervous system.

Objectives: To analyse and compare absolute and interpeak latencies of ABR in infants with and without IDA.

Methods: ABR traces were obtained from 40 anemic ears and 40 non anemic ears, aged 6-24 months. Read More

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http://dx.doi.org/10.1016/j.ijporl.2018.11.017DOI Listing
February 2019

Oral versus intravenous iron therapy for postpartum anemia: A systematic review and meta-analysis.

Am J Obstet Gynecol 2018 Dec 19. Epub 2018 Dec 19.

Associate Professor in Anesthesiology, Stanford University School of Medicine.

Objective: To perform a systematic review of randomized trials comparing oral versus intravenous iron therapy to treat postpartum anemia.

Data Sources: Data sources were: PubMed (1972-2017); Cochrane Central Register of Controlled Trials, CENTRAL (1972-2017); CINAHL (1972-2017); Web of Science; Excerpta Medica Database, and EMBASE (1972-2017).

Study Eligibility Criteria: We included randomized trials comparing oral versus intravenous iron monotherapy to treat postpartum anemia (classified as a hemoglobin<12 g/dL). Read More

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http://dx.doi.org/10.1016/j.ajog.2018.12.016DOI Listing
December 2018
2 Reads

Use of Encapsulation Technology to Improve the Efficiency of an Iron Oral Supplement to Prevent Anemia in Suckling Pigs.

Animals (Basel) 2018 Dec 20;9(1). Epub 2018 Dec 20.

Faculty of Veterinary Sciences, University of Chile, Santiago 8820808, Chile.

The objective of this study was to develop an encapsulated iron supplement for oral ingestion and to determine its effect on the iron nutrition status of suckling pigs. Encapsulated and non-encapsulated iron supplement was prepared. Seventy-two neonatal piglets were assigned to three experimental groups: (1) parenteral group (gold standard treatment), which received one dose of parenteral iron (200 mg), 2 days of age, (2) "non-encapsulated" group (as a control group), which received 4 oral doses of unencapsulated iron supplement at 2, 7, 12 and 17 days of age, and (3) "encapsulated" group, which received 4 oral doses of encapsulated iron supplement on the same days. Read More

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http://dx.doi.org/10.3390/ani9010001DOI Listing
December 2018
1 Read

Buffered or impaired: Maternal anemia, inflammation and breast milk macronutrients in northern Kenya.

Am J Phys Anthropol 2019 Feb 21;168(2):329-339. Epub 2018 Dec 21.

Center for Studies in Demography and Ecology, University of Washington, Seattle, Washington.

Background: Maternal anemia has adverse consequences for the mother-infant dyad. To evaluate whether and how milk nutrient content may change in ways that could "buffer" infants against the conditions underlying maternal anemia, this study assessed associations between milk macronutrients and maternal iron-deficiency anemia (IDA), non-iron-deficiency anemia (NIDA), and inflammation.

Methods: A secondary analysis of cross-sectional data and milk from northern Kenya was conducted (n = 204). Read More

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http://dx.doi.org/10.1002/ajpa.23752DOI Listing
February 2019

Anemia revealing a collagenous gastritis in a young Tunisian man.

Pan Afr Med J 2018 26;30:231. Epub 2018 Jul 26.

Gastroenterology Department, Farhat Hached Hospital, Sousse, Tunisia.

Collagenous gastritis is a rare entity, characterized by the deposition of a subepithelial collagenous band with an inflammatory infiltrate in the mucosa. We report the first Tunisian case revealed by severe anemia. Lesions were limited to the stomach and remained unchanged on 3 series biopsies during a 24 month follow up despite treatment with corticosteroids. Read More

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http://www.panafrican-med-journal.com/content/article/30/231
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http://dx.doi.org/10.11604/pamj.2018.30.231.12981DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295307PMC
January 2019
7 Reads

Systematic review to investigate the safety of induction and augmentation of labour among pregnant women with iron-deficiency anaemia.

BMJ Open 2018 Dec 19;8(12):e021793. Epub 2018 Dec 19.

National Perinatal Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.

Objective: To conduct a systematic review to investigate the safety of induction and/or augmentation of labour compared with spontaneous-onset normal labour among pregnant women with iron-deficiency anaemia.

Design: Systematic review.

Setting: Studies from all countries, worldwide. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-021793DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303660PMC
December 2018
1 Read

Non-small bowel lesion detection at small bowel capsule endoscopy: A comprehensive literature review.

World J Clin Cases 2018 Dec;6(15):901-907

Centre for Gastroenterology, Royal Free Hospital, Pond St, London NW3 2QG, United Kingdom.

Small bowel capsule endoscopy is a minimally-invasive endoscopic investigation that is often used in clinical practice to investigate overt or occult gastrointestinal (GI) bleeding among other clinical indications. International guidance recommends small bowel capsule endoscopy as a first-line investigation to detect abnormalities in the small bowel, when gastroscopy and colonoscopy fail to identify a cause of GI bleeding. It can diagnose with accuracy abnormalities in the small bowel. Read More

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http://www.wjgnet.com/2307-8960/full/v6/i15/901.htm
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http://dx.doi.org/10.12998/wjcc.v6.i15.901DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288513PMC
December 2018
4 Reads

Splenectomy for breast carcinoma diffusely metastatic to the spleen presenting as severe transfusion-dependent anaemia and thrombocytopaenia.

BMJ Case Rep 2018 Dec 18;11(1). Epub 2018 Dec 18.

Surgical Oncology Service, Hillel Yaffe Medical Center, Hadera, Israel.

We report a 48-year-old woman with metastatic infiltrating lobular carcinoma of the breast. Though her metastatic disease remained stable, she was repeatedly admitted for symptomatic anaemia and treated by red blood cell and platelet transfusions with increasing frequency as time elapsed. Abdominal examination and ultrasound revealed splenomegaly (27 cm span). Read More

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http://dx.doi.org/10.1136/bcr-2017-223453DOI Listing
December 2018
1 Read

Polyarticular arthropathy and encephalopathy in a 70-year-old woman.

BMJ Case Rep 2018 Dec 13;11(1). Epub 2018 Dec 13.

Bendat Respiratory Research and Development Fund, Perth, Western Australia, Australia.

A 70-year-old woman with a background of portopulmonary hypertension, managed with sildenafil and oral diuretics, and cirrhosis, presented with acute on chronic haemorrhoidal bleeding, iron deficiency anaemia and worsening right heart failure. She presented in a normal conscious and cognitive state. Management involved intravenous diuresis with frusemide and blood transfusion. Read More

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http://dx.doi.org/10.1136/bcr-2018-227058DOI Listing
December 2018
2 Reads

Response by Anand and Gupta to Letter Regarding Article, "Anemia and Iron Deficiency in Heart Failure: Current Concepts and Emerging Therapies".

Circulation 2018 Dec;138(25):2976-2977

VA Long Beach Healthcare System, CA (P.G.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.037553DOI Listing
December 2018
14.430 Impact Factor

Letter by de las Nieves Lopez Regarding Article, "Anemia and Iron Deficiency in Heart Failure: Current Concepts and Emerging Therapies".

Circulation 2018 Dec;138(25):2974-2975

Instituto de Gestión Sanitaria, Area Sanitaria de Mellilla, Spain.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.037239DOI Listing
December 2018

Whole-colon investigation vs. flexible sigmoidoscopy for suspected colorectal cancer based on presenting symptoms and signs: a multicentre cohort study.

Br J Cancer 2018 Dec 19. Epub 2018 Dec 19.

Cancer Screening and Prevention Research Group, Department of Surgery and Cancer, Imperial College London, London, UK.

Background: Patients with suspected colorectal cancer (CRC) usually undergo colonoscopy. Flexible sigmoidoscopy (FS) may be preferred if proximal cancer risk is low. We investigated which patients could undergo FS alone. Read More

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http://dx.doi.org/10.1038/s41416-018-0335-zDOI Listing
December 2018
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Prevalence and risk factors of preconception anemia: A community based cross sectional study of rural women of reproductive age in northeastern Tanzania.

PLoS One 2018 18;13(12):e0208413. Epub 2018 Dec 18.

Centre for Medical Parasitology, Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark.

Background: Anemia is a major public health problem that adversely affects pregnancy outcomes. The prevalence of anemia among pregnant women before conception is not well known in Tanzania. The aim of this study was to determine the prevalence, types, and risk factors of preconception anemia in women of reproductive age from a rural Tanzanian setting. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0208413PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298689PMC
December 2018

The Levels of Hepcidin and Erythropoietin in Pregnant Women with Anemia of Various Geneses.

Open Access Maced J Med Sci 2018 Nov 23;6(11):2111-2114. Epub 2018 Nov 23.

Karaganda State Medical University, Karaganda, Kazakhstan.

Aim: The purpose of the present research was to study the content of erythropoietin and hepcidin in serum in pregnant women with iron deficiency anaemia and anaemia of chronic inflammation.

Methods: The authors examined 98 pregnant women who were observed in LLP (Regional obstetric-gynaecological centre) in Karaganda. The including criteria for pregnant women in the study was the informed consent of the woman to participate in the study. Read More

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https://www.id-press.eu/mjms/article/view/oamjms.2018.471
Publisher Site
http://dx.doi.org/10.3889/oamjms.2018.471DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290438PMC
November 2018
2 Reads