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Ophthalmic Plast Reconstr Surg 2022 Apr 25. Epub 2022 Apr 25.

Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, U.S.A.

A 59-year-old woman presented with iritis and uveitis in the OD approximately 3 weeks after she underwent a bilateral upper and lower blepharoplasty by an outside oculoplastic specialist. Examination revealed a visual acuity of hand motion in the OD, scleral ulceration suspicious for prior globe perforation, dense vitritis, and loculations and membranes on echography. The patient was diagnosed with acute onset exogenous endophthalmitis. Read More

Rev Peru Med Exp Salud Publica 2021 Oct-Dec;38(4):621-626. Epub 2022 Apr 1.

Instituto de Investigaciones Biomédicas "Dr. Francisco J. Triana Alonso". Facultad de Ciencias de la Salud Sede Aragua, Universidad de Carabobo, Aragua, Venezuela.

The objective of this study was to determine ocular manifestations of toxocariasis in schoolchildren. A study was conducted in two schools in the Anzoátegui state in Venezuela in 2019. The ELISA test was used to determine IgG antibodies against Toxocara spp. Read More

Vaccines (Basel) 2022 Mar 21;10(3). Epub 2022 Mar 21.

Xiamen Eye Center, Xiamen University, Xiamen 361005, China.

To report potential vaccine-induced ocular adverse events following inactivated COVID-19 vaccination (Sinopharm and Sinovac). This case series took place at a tertiary referral center in the southeast of China (Xiamen Eye Center in Fujian Province) from February 2021 to July 2021. Patients who received the first dose of inactivated COVID-19 vaccine and developed vaccine-related ocular adverse events within 10 days were included. Read More

J Investig Med High Impact Case Rep 2022 Jan-Dec;10:23247096221086450

Department of General Medicine, Okayama University Hospital, Japan.

A 34-year-old Japanese person with male gender identity who had been taking intramuscular injection of methyltestosterone depot for 11 years after bilateral mastectomy noticed blurred vision 5 days after the second vaccination for COVID-19 (Tozinameran; Pfizer-BioNTech) in the interval of 3 weeks following the first vaccination. The patient was diagnosed as granulomatous iritis with mutton-fat keratic precipitates and small iris nodules at the pupillary margin in the right eye and began to have 0.1% betamethasone eye drops with good response. Read More

J Glaucoma 2022 04;31(4):218-223

Department of Ophthalmology, Scheie Eye Institute.

Prcis: In primary angle closure suspects (PACS), self-identified Black race was a risk factor for intraocular pressure (IOP) elevation and iritis following laser peripheral iridotomy (LPI). Laser type was not associated with either immediate post-LPI IOP elevation or iritis in multivariate analysis.

Purpose: The aim was to determine the impact of laser type and patient characteristics on the incidence of IOP elevation and iritis after LPI in PACS. Read More

J Rheumatol 2022 05 1;49(5):523-530. Epub 2022 Feb 1.

J. Widdifield, PhD, Sunnybrook Research Institute, ICES, Institute of Health Policy, Management, & Evaluation, University of Toronto, Toronto, Ontario, Canada.

Objective: To investigate coronavirus disease 2019 (COVID-19) hospitalization risk in patients with immune-mediated inflammatory diseases (IMIDs) compared with matched non-IMID comparators from the general population.

Methods: We conducted a population-based, matched cohort study using health administrative data from January to July 2020 in Ontario, Canada. Cohorts for each of the following IMIDs were assembled: rheumatoid arthritis (RA), psoriasis, psoriatic arthritis (PsA), ankylosing spondylitis, systemic autoimmune rheumatic diseases (SARDs), multiple sclerosis (MS), iritis, inflammatory bowel disease, polymyalgia rheumatica, and vasculitis. Read More

Int J Retina Vitreous 2022 Jan 18;8(1). Epub 2022 Jan 18.

Retina Associates of Cleveland Inc, 24075 Commerce Park, Cleveland, OH, USA.

Background: Intravitreal injections (IVIs), a common treatment in ophthalmology, result in acute complications and urgent follow-up visits causing significant burden to both patient and physician. We evaluated the incidence of acute complications following IVIs which occurred within seven days of injection.

Methods: A retrospective cohort study conducted at a private retinal practice, in Cleveland, Ohio. Read More

Am J Ophthalmol 2022 02 12;234:250-258. Epub 2021 Oct 12.

Foster Center for Ocular Immunology, Duke Eye Institute, Durham, North Carolina, USA (M.S., H.M.M., C.S., V.L.P.); and Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina, USA (M.S., H.M.M., A.A.J., C.S., V.L.P.). Electronic address:

Purpose: To investigate the diagnosis and management of patients with idiopathic persistent iritis after cataract surgery (IPICS).

Design: Retrospective interventional case series.

Methods: Patients diagnosed with IPICS were evaluated for demographic and clinical characteristics and immune blood markers. Read More

J Med Case Rep 2021 Sep 23;15(1):482. Epub 2021 Sep 23.

Department of Rheumatology, Allergy and Clinical Immunology, National Hospital Organization Chibahigashi National Hospital, 673 Nitona-cho, Chuou-ku, Chiba City, Chiba, 260-8712, Japan.

Background: Tubulointerstitial nephritis and uveitis syndrome is a rare lymphocyte-related oculorenal inflammatory disease presumed to be associated with drug use and infectious agents. Toxoplasma gondii is one of such pathogens that could exhibit encephalitis, meningitis, and uveitis in immunocompromised or in some immunocompetent individuals. If the immunoglobulin M of Toxoplasma is positive on screening, the interpretation of the result is not simple, especially when immunoglobulin M stays positive persistently. Read More

Front Med (Lausanne) 2021 2;8:686427. Epub 2021 Jul 2.

Advanced Eye Centre, Post-Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.

Herpes simplex virus (HSV) and varicella zoster virus (VZV) are the most common ocular pathogens associated with infectious anterior uveitis. Currently, there are a number of antiviral agents administered to treat viral anterior uveitis (VAU). However, there is no consensus or guidelines about the most appropriate approach leading for the best treatment outcomes with fewer ocular complications. Read More

United European Gastroenterol J 2021 06 2;9(5):581-589. Epub 2021 Jun 2.

Department of Internal Medicine III, Division of Gastroenterology and Hepatology, Medical University of Vienna, Vienna, Austria.

This post hoc analysis of the UNITI studies found ustekinumab (UST) did not significantly improve overall extraintestinal manifestations (EIMs) of Crohn's disease compared to placebo-treated patients at weeks 6 and 52.

Background And Aims: The UNITI trials demonstrated that UST was effective in inducing and maintaining clinical remission in Crohn's disease (CD). However, limited data exists regarding its effectiveness for treatment of EIMs. Read More

J Cataract Refract Surg 2021 Sep;47(9):1147-1152

From the Department of Ophthalmology, Oslo University Hospital, Oslo, Norway (Dalby, Drolsum, Kristianslund); Institute of Clinical Medicine, University of Oslo, Oslo, Norway (Dalby, Drolsum, Kristianslund).

Purpose: To evaluate the long-term efficacy and safety after intraocular lens (IOL) repositioning by scleral suturing of 1-piece IOL compared with other IOL designs in the treatment of late in-the-bag IOL dislocation.

Setting: Patients referred to Oslo University Hospital Oslo, Norway.

Design: Prospective cohort study. Read More

Inflamm Bowel Dis 2021 Jun;27(7):e83-e86

Department of Gastroenterology, First Affiliated Hospital, China Medical University, Shenyang City, Liaoning Province, China.

Jpn J Ophthalmol 2021 Mar 11;65(2):184-190. Epub 2021 Mar 11.

Department of Ophthalmology, Tokyo Medical University Hospital, Tokyo, Japan.

Purpose: To investigate the epidemiology of uveitis in Japan and assess its changes over time.

Study Design: Retrospective multicenter study METHODS: Sixty-six hospitals in Japan with uveitis specialty clinics participated in this retrospective nationwide survey. A questionnaire was sent to each hospital to survey the total number of patients who made a first visit to the outpatient uveitis clinic of each hospital between 1 April 2016 and 31 March 2017. Read More

Int Ophthalmol 2021 May 5;41(5):1671-1679. Epub 2021 Feb 5.

Department of Ophthalmology, Jichi Medical University Saitama Medical Center, 1-847 Amanuma-cho, Omiya-ku, Saitama, 330-8503, Japan.

Purpose: To clarify the clinical features of uveitis in elderly patients in central Tokyo.

Methods: We retrospectively identified 1424 patients with uveitis who visited the Uveitis Clinic of the University of Tokyo Hospital between January 2013 and December 2018. The patients were categorized into two groups based on their ages at the time of disease onset: patients aged 65 years or older were included in Group A, whereas those younger than 65 years were included in Group B. Read More

Am J Emerg Med 2021 Apr 4;42:217-220. Epub 2020 Dec 4.

Bascom Palmer Eye Institute, University of Miami, Miami, FL, United States of America.

Objective: To characterize injuries caused by exercise resistance bands.

Method: Single-site retrospective case series of patients presenting to the Bascom Palmer Eye Institute emergency room with ocular injuries secondary to exercise resistance bands from March through September 2020.

Results: Eleven patients (9 males, 2 females, 14 eyes) were reviewed. Read More

Int Ophthalmol 2021 Mar 11;41(3):973-980. Epub 2020 Nov 11.

Department of Pediatric Ophthalmology and Squint Services, Aravind Eye Hospital and Post Graduate Institute of Ophthalmology, Madurai, India.

Purpose: To report clinical outcomes of retropupillary iris-suture-fixated rigid intraocular lens (IFIOL) SETTING: Tertiary care ophthalmic hospital DESIGN: Retrospective study METHODS: This study included all eyes undergoing IFIOL with a minimum follow-up of 6 months between April 2017 and January 2019. Patients with preexisting anterior or posterior segment pathologies causing defective vision, uveitis or history of previous intraocular surgeries with exception of cataract surgery were excluded from the study. Data were retrieved from electronic medical records, and we documented demographics, history, position of cataractous lens or IOL, primary/secondary surgery and its complications. Read More

Eur J Ophthalmol 2021 Sep 4;31(5):2446-2450. Epub 2020 Nov 4.

Clinical Immunology, Angioedema and Allergy Unit, Center for Autoimmune Diseases, Sheba Medical Center, Tel Hashomer, Israel.

Purpose: To evaluate the prevalence of a spectrum of autoantibodies in adult patients with non-infectious uveitis compared to healthy controls.

Methods: This is a case-control study conducted in a tertiary referral center. Serum positivity to auto-antibodies directed at membranous phospholipids (aPL), nuclear antigens, and cytoplasmic (ANCA) antigens were assessed in sera from 63 non-infectious uveitis patients, and 78 healthy controls. Read More

J Ophthalmic Inflamm Infect 2020 Oct 29;10(1):26. Epub 2020 Oct 29.

Department of Ophthalmology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Nishi 7, Kita 15, Kita-ku, Sapporo, 060-8638, Japan.

Aim: To report a patient with multiple evanescent white dot syndrome (MEWDS) complicated by iridocyclitis and vitritis.

Case Description: A 70-year-old woman developed multiple subretinal white dots, iritis, and diffuse vitreous opacity. Angiographic and macular morphological features were consistent with those of MEWDS. Read More

Ophthalmologe 2021 10 25;118(10):1045-1047. Epub 2020 Oct 25.

Klinik und Poliklinik für Augenheilkunde, Universitätsklinikum Regensburg, Franz-Josef-Strauß-Allee 11, 93053, Regensburg, Deutschland.

Clin Ophthalmol 2020 24;14:2799-2806. Epub 2020 Sep 24.

Department of Ophthalmology, Osaka Medical College, Takatsuki, Japan.

Purpose: To review clinical characteristics of ocular inflammation patients in Osaka, Japan, over 20 years and investigate the efficacy of required surgeries.

Methods: We conducted a retrospective study involving 2730 eyes of 1815 patients with ocular inflammation examined at the Osaka Medical College Hospital from April 1999 to March 2019.

Results: Patients comprised 843 males and 972 females, with a mean age of 56. Read More

RMD Open 2020 08;6(2)

Medicine, Division of Rheumatology, Western University, London, Canada

Objectives: This meta-analysis investigated the frequency of ocular involvement in childhood and adult spondyloarthritis (SpA).

Methods: A systematic review of the literature was conducted. Medline, Web of Science and Cochrane databases were searched upto October 2018 identifying publications related to SpA, including ankylosing spondylitis (AS) with ocular conditions (OC) (uveitis, iritis, retinitis, chorioretinitis and other ocular involvement). Read More

Int Med Case Rep J 2020 5;13:331-334. Epub 2020 Aug 5.

Department of Medicine, College of Medicine, Umm Alqura University, Makkah, Saudi Arabia.

Secukinumab, "an IL-17 antagonist", is one of the biological agents used to treat active ankylosing spondylitis (AS). Although it has been proven that certain agents are linked with a paradoxical increase in uveitis, there are limited data on whether secukinumab has this effect or not. We report a case of a new-onset anterior uveitis after 6 months of starting secukinumab in a 47-year-old male, HLA-B27 positive AS patient. Read More

J Cataract Refract Surg 2020 Jun;46(6):867-872

From the Eyes of York Cataract & Laser Center (Visco), York, Pennsylvania, USA; IrisARC (Bedi), Chandigarh, India.

Purpose: To assess the effectiveness of intracameral phenylephrine-ketorolac during cataract surgery compared with postoperative topical steroids in reducing the incidence of postoperative clinical cystoid macular edema (CME) confirmed via optical coherence tomography (OCT), breakthrough iritis, pain, and photophobia.

Setting: Ambulatory surgical center/clinical practice.

Design: Retrospective 2-cohort study. Read More

Pediatr Rheumatol Online J 2020 Mar 23;18(1):26. Epub 2020 Mar 23.

Department of Lifetime Clinical Immunology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan.

Background: Juvenile idiopathic arthritis-associated uveitis (JIA-U) is a serious condition associated with the risk of blindness. However, pediatric rheumatologists rarely encounter cases of blindness, because most patients reach adulthood during the course of follow-up before blindness occurs. Here, we report the progress of 9 patients with JIA-U, including 2 patients who became blind after the transition period. Read More

Rheumatology (Oxford) 2020 09;59(9):2199-2206

Department of Academic Rheumatology, Liverpool University Hospitals.

Objective: To describe the prevalence of extra-articular manifestations-enthesitis, dactylitis, nail disease, uveitis and IBD-in PsA, and their impact on longitudinal disease outcomes.

Methods: We searched Medline, PubMed, Scopus and Web of Science using a predefined protocol in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Studies using imaging to define extra-articular manifestations (EAMs) were excluded. Read More

Ocul Immunol Inflamm 2021 Jul 20;29(5):991-996. Epub 2020 Feb 20.

Department of Ophthalmology & Visual Science, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.

ABSTARCT: To investigate ocular manifestations in patients positive for serum anti-neutrophil cytoplasmic antibodies (ANCAs) in Japan.: The clinical records of patients who had ocular manifestations and who were serum ANCA positive between 2011-2017 at Tokyo Medical and Dental University Hospital were retrospectively reviewed.: Eighteen patients were identified to be positive for serum ANCA and had ocular manifestations, including optic nerve involvement (50%), scleritis (27. Read More