Search Our Scientific Publications & Authors

J Glaucoma 2019 Mar 26. Epub 2019 Mar 26.

Department of Epidemiology, Epidemiology Data Center, Graduate School of Public Health, University of Pittsburgh, PA.

Precis: In the absence of prophylactic anti-inflammatory therapy, anterior chamber inflammation (characterized by cells and less commonly flare) is minimal and transient after selective laser trabeculoplasty in Afro-Caribbean glaucoma patients.

Purpose: To characterize the prevalence, severity, and duration of anterior chamber inflammation (cells and flare) following selective laser trabeculoplasty (SLT) in Afro-Caribbean eyes with primary open-angle glaucoma (POAG).

Methods: 144 eyes of 72 POAG patients underwent first-time 360-degree SLT treatment following washout of all topical medications in the prospective West Indies Glaucoma Laser Study. Read More

N Engl J Med 2019 Mar;380(11):1062-1071

From the Departments of Ophthalmology, Medicine, and Cell Biology, Oregon Health and Science University, and Legacy Devers Eye Institute - both in Portland (J.T.R.); and the Department of Ophthalmology, Ophthalmic Consultants of Boston (L.M.R.), the Departments of Radiology (K.A.B.), Medicine (M.B.B.), and Pathology (M.P.H.), Massachusetts General Hospital, and the Departments of Radiology (K.A.B.), Medicine (M.B.B.), and Pathology (M.P.H.), Harvard Medical School - all in Boston.

Ocul Immunol Inflamm 2019 Feb 27:1-4. Epub 2019 Feb 27.

a Hospital Del Salvador, Facultad de Medicina , Universidad de Chile , Santiago , Chile.

Purpose: To describe clinical features of patients with diabetes mellitus-associated uveitis (DMAU).

Methods: Retrospective analysis of clinical records of patients with uveitis and diabetes mellitus (DM) presented in an uveitis referral centre in Chile. Demographic data, comorbidities, complete ophthalmic examination, and treatments were analyzed. Read More

J Ophthalmic Inflamm Infect 2019 Feb 18;9(1). Epub 2019 Feb 18.

Storm Eye Institute, Medical University of South Carolina, 167 Ashley Avenue, Charleston, SC, 29425, USA.

Background: The purpose of this study was to evaluate patients with persistent iritis after cataract surgery to determine its incidence and risk factors. Adjusting the management of patients at risk could allow for a more predictable post-operative course and outcome. A retrospective chart review was performed of patients who had post-operative iritis longer than 1 month after cataract surgery during a 2-year period at Storm Eye Institute at the Medical University of South Carolina (MUSC) in Charleston, South Carolina. Read More

N Engl J Med 2018 12 1;379(25):2407-2416. Epub 2018 Oct 1.

From the Department of Medicine, Faculty of Medical and Health Sciences, University of Auckland (I.R.R., A.M.H., B.M., A.S., E.G., S.W., K.R.W., M.J.B., G.D.G.), and the Auckland District Health Board (I.R.R., S.B.) - both in Auckland, New Zealand.

Background: Bisphosphonates prevent fractures in patients with osteoporosis, but their efficacy in women with osteopenia is unknown. Most fractures in postmenopausal women occur in those with osteopenia, so therapies that are effective in women with osteopenia are needed.

Methods: We conducted a 6-year, double-blind trial involving 2000 women with osteopenia (defined by a T score of -1. Read More

Case Rep Infect Dis 2018 18;2018:2840241. Epub 2018 Feb 18.

University of Nebraska Medical Center, S. 42nd and Emile St., Omaha, NE, USA.

. is known as the "great masquerader" for its many presentations and ocular findings in patients who are infected and develop secondary and tertiary stage of syphilis. Syphilitic ocular manifestations include uveitis, chorioretinitis, retinitis, vasculitis, vitritis, and panuveitis all with or without decreased visual acuity. Read More

Inflamm Bowel Dis 2018 Apr 13. Epub 2018 Apr 13.

AbbVie Inc., North Chicago, Illinois.

Background: Extra-intestinal manifestations (EIMs) can impact morbidity in patients with inflammatory bowel diseases (IBD; Crohn's disease [CD] and ulcerative colitis [UC]). This study compared incidence rates of EIMs in patients with moderate to severe IBD receiving gut-selective vedolizumab (VDZ) vs those receiving systemic anti-tumor necrosis factor (anti-TNF) therapies.

Methods: Adult IBD patients receiving VDZ or anti-TNFs were identified from the MarketScan claims database from September 28, 2012, through September 30, 2016. Read More

Ocul Immunol Inflamm 2017 Oct 13:1-8. Epub 2017 Oct 13.

a Glaucoma Service , Wills Eye Institute , Philadelphia , Pennsylvania , USA.

There is debate concerning whether the use of Latanoprost in early postoperative period of cataract surgery and in glaucoma patients with uveitis as it may aggravate the inflammation and results in macular edema (ME), because of blood-ocular barrier disruption. However, there is no solid evidence for disruption of blood-ocular barrier with Latanoprost and aggravation of uveitis or ME formation. Similar to pseudophakic ME, the imaging ME in cases claimed to be secondary to Latanoprost is greater than clinical ME, happens mostly in complicated surgeries, and the vast majority resolve within weeks to months with using a non-steroidal anti-inflammatory drug. Read More

Postgrad Med J 2017 Dec 23;93(1106):766-773. Epub 2017 Sep 23.

Department of Ophthalmology, University Hospital Birmingham NHS Foundation Trust, Birmingham, UK.

Uveitis describes a group of conditions characterised by intraocular inflammation. The term uveitis technically describes inflammation of the uvea which comprises the iris, ciliary body and choroid, however now encompasses inflammation of adjacent intraocular structures such as the retina, vitreous and optic nerve. Uveitis is a significant cause of blindness worldwide, but its impact is generally underappreciated due to a lack of awareness and understanding of the condition among the public and most non-ophthalmic healthcare professionals. Read More

Lakartidningen 2017 09 1;114. Epub 2017 Sep 1.

Orebro Universitet Instiitutionen for Halsoakademin och Medicin - Orebro, Sweden.

Floorball - a common cause of sport related eye injury The aim of this study was to survey the incidence and type of sport related to eye injuries with special interest in floorball. A prospective study was conducted December 1st 2013 through November 30th 2014 at the Department of Ophthalmology, Örebro University Hospital. All patients presenting with an acute sports related eye injury were offered to be included. Read More

Clin Ophthalmol 2017 15;11:1151-1156. Epub 2017 Jun 15.

Department of Ophthalmology, Jichi Medical University, Shimotsuke, Tochigi, Japan.

Purpose: To investigate uveitis incidence of new patients who visited Jichi Medical University Hospital, Tochigi, north of Tokyo, during 2011-2015, and to compare the results with previously reported data from other facilities.

Methods: We retrospectively analyzed clinical records of new patients with uveitis from April 2011 to March 2015 and compared the uveitis incidence with those from other hospitals.

Results: A total of 502 patients were enrolled in the study; definite diagnoses were made in 262 patients (52. Read More

Prog Retin Eye Res 2017 07 29;59:178-201. Epub 2017 Apr 29.

Cole Eye Institute, Cleveland Clinic, Cleveland, OH, USA.

Since its introduction in the early 1990s, optical coherence tomography (OCT) has evolved in resolution and technological advances, and in recent years its initial application of assessing the morphology of a tissue has been implemented by the study of its functional blood flow, through optical coherence tomography angiography (OCTA). This novel technique details capillary networks by comparing the amount of light returned from static and moving targets without the need for intravenous dye administration. While this imaging modality has been used for various ocular conditions, the application OCTA to uveitis conditions remains sparse. Read More

J Eur Acad Dermatol Venereol 2017 Apr 7;31(4):705-711. Epub 2016 Dec 7.

Department of Medicine, Chittagong Medical College, Chittagong, Bangladesh.

Background: Leprosy reactions are immunologically mediated conditions and a major cause of disability before, during and after multidrug therapy (MDT). Little data have been published on the epidemiology of leprosy reactions in Bangladesh.

Objectives: To describe the pattern and prevalence of leprosy reactions in the postelimination stage. Read More

Ocul Immunol Inflamm 2017 11;25(sup1):S100-S106. Epub 2016 Oct 11.

e Ho Chi Minh Eye Hospital , Ho Chi Minh City , Vietnam.

Purpose: To describe the pattern of uveitis among Vietnamese at two eye hospitals in Southern Vietnam.

Methods: We retrospectively reviewed the charts of 212 consecutive uveitis cases that presented to two eye hospitals in Ho Chi Minh City, Vietnam, from July 2011 to February 2015. The patients were identified from a database maintained by the hospitals. Read More

Ocul Immunol Inflamm 2018 11;26(2):242-248. Epub 2016 Aug 11.

a Wilmer Eye Institute, Johns Hopkins University , Baltimore , MD , USA.

Purpose: To guide risk management in uveitis.

Methods: Retrospective review of malpractice verdicts, rulings, and settlements.

Results: The WestLaw® database was reviewed for lawsuits related to uveitis in the United States from 1930-2014. Read More

West J Emerg Med 2016 Jul 21;17(4):473-6. Epub 2016 Jun 21.

University of Texas, Health Science Center, San Antonio, Department of Emergency Medicine, San Antonio, Texas.

This case describes an emergency department (ED) presentation of ocular syphilis in a human immunodeficiency virus (HIV) infected patient. This is an unusual presentation of syphilis and one that emergency physicians should be aware of. The prevalence of syphilis has reached epidemic proportions since 2001 with occurrences primarily among men who have sex with men (MSM). Read More

BMC Infect Dis 2016 Jul 16;16:332. Epub 2016 Jul 16.

Institute for Medical Microbiology and Hospital Epidemiology, Hannover Medical School, Hannover, Germany.

Background: The majority of cases of endophthalmitis are caused by exogenous pathogens; only 5-10 % are of endogenous origin. One cause of these rare cases of endogenous endophthalmitis is Listeria monocytogenes. Twenty-six cases of endophthalmitis due to this pathogen have been published over the last twenty years. Read More

Mod Rheumatol 2017 Mar 14;27(2):345-349. Epub 2016 Jul 14.

d Division of Rheumatology, Department of Physical Medicine and Rehabilitation , Erciyes University, Faculty of Medicine , Kayseri , Turkey , and.

Objectives: To assess gender related differences in a cohort of patients with psoriatic arthritis (PsA).

Methods: Consecutively recruited patients were included and underwent clinical, radiological and laboratory evaluation by using standardized protocol and case report forms.

Results: Women (n = 115) with PsA had higher symptom duration and body mass index (BMI), tender and swollen joint counts, disease activity score-28 joints (DAS28), Erythrocyte sedimentation rate (ESR) and poorer physical activity and fatigue than men (n = 72) with PsA. Read More

Bioimpacts 2016 30;6(1):49-67. Epub 2016 Mar 30.

Research Centre for Pharmaceutical Nanotechnology, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.

Introduction: Ocular targeted therapy has enormously been advanced by implementation of new methods of drug delivery and targeting using implantable drug delivery systems (DDSs) or devices (DDDs), stimuli-responsive advanced biomaterials, multimodal nanomedicines, cell therapy modalities and medical bioMEMs. These technologies tackle several ocular diseases such as inflammation-based diseases (e.g. Read More

Clin Interv Aging 2016 17;11:651-7. Epub 2016 May 17.

Department of Ophthalmology, National and Kapodistrian University of Athens, Athens, Greece.

Purpose: The aim of this study was to compare the results of phacoemulsification through a small pupil using minimal iris manipulation versus phacoemulsification through a well-dilated pupil.

Methods: This prospective randomized control (comparative) study comprised 78 patients (group I) with a maximally dilated pupil size of ≤4.00 mm and 45 patients (group II) with dilated pupil size of ≥7. Read More

Ophthalmologe 2017 Jan;114(1):74-76

Augenklinik und Poliklinik, Universitätsmedizin der Johannes Gutenberg-Universität Mainz, Langenbeckstr. 1, 55131, Mainz, Deutschland.

Ocul Immunol Inflamm 2016 Aug 27;24(4):470-5. Epub 2016 May 27.

a Casey Eye Institute, Oregon Health & Science University , Portland , Oregon , USA.

Acute anterior uveitis is generally recognized as the most common form of uveitis. An association with HLA-B27 is seen in approximately half of cases of acute anterior uveitis. The prevalence of HLA-B27 varies widely between ethnic populations, with an approximate 8-10% prevalence in non-Hispanic whites and lower prevalence in Mexican- (4%) and African- (2-4%) Americans. Read More

Dig Dis Sci 2016 09 19;61(9):2619-26. Epub 2016 May 19.

Division of Epidemiology and Public Health, University of Nottingham, Nottingham, UK.

Background And Aims: Extra-intestinal manifestations are well recognized in inflammatory bowel disease (IBD). To what extent the commonly recognized extra-intestinal manifestations seen in IBD patients are attributable to IBD is, however, not clear due to the limited number of controlled studies published.

Methods: We have conducted a study of these manifestations using electronic primary care records. Read More

Ocul Oncol Pathol 2015 Dec 22;2(2):80-5. Epub 2015 Sep 22.

Departments of Ophthalmology and Pathology, State University of New York, Upstate Medical University, Syracuse, N.Y., USA.

Background/aims: To report a case of cutaneous malignant melanoma with cerebral metastasis found to have vitreoretinal metastasis upon referral for neovascular glaucoma.

Methods: The clinical history and ocular examination findings, including histologic, cytologic, genetic, and immunohistochemical features of the vitreoretinal metastatic tumor, were reviewed. Additionally, the histologic and immunohistochemical features of the primary skin tumor and brain metastasis were also assessed. Read More

Ocul Oncol Pathol 2015 Dec 9;2(2):62-5. Epub 2015 Sep 9.

Departments of Ophthalmology, Bronx, N.Y., USA.

Purpose: To report a case of recurrent immunodeficiency-associated Burkitt lymphoma (BL) that initially presented as severe anterior uveitis.

Methods: Case report.

Results: To our knowledge, this is the first reported case of isolated anterior uveitis related to immunodeficiency-associated BL. Read More

J La State Med Soc 2015 Jul-Aug;167(4):172-6. Epub 2015 Aug 15.

Louisiana State University Health Sciences Center in New Orleans.

Several factors acting in concert now place US residents, returning travelers, and expatriates at risks of contracting ocular filariasis including increasing seroprevalence rates of zoonotic filariasis, international travel bringing tourists to and expatriates from filariasis-endemic regions, and warming temperatures extending distribution ranges of arthropod vectors. To describe the epidemiology and outcomes of ocular filariasis and to recommend strategies for the diagnosis, management, and prevention of ocular filariasis, internet search engines were queried with the key words in order to examine case reports and series of ocular filariasis in the US and elsewhere. Descriptive epidemiological, morphological, and molecular evidence now support increasing cases of ocular filariasis in domestic and wild animals and humans, with most cases caused by filarial worms including Dirofilaria repens and other zoonotic Dirofilaria species and Onchocerca lupi and other zoonotic Onchocerca species. Read More

Ocul Immunol Inflamm 2017 Oct 12;25(5):589-595. Epub 2016 Apr 12.

a Massachusetts Eye Research and Surgery Institution , Waltham , Massachusetts , USA.

Purpose: To describe differences in the clinical characteristics of birdshot retinochoroidopathy (BSRC) patients diagnosed early and later in life.

Methods: This is a retrospective cohort study. Age was primarily analyzed and 50 years of age at diagnosis was selected as a cut-off point. Read More

J Cataract Refract Surg 2016 Feb;42(2):211-6

From the University of South Dakota Sanford School of Medicine (Terveen, Berdahl), and Vance Thompson Vision (Berdahl), Sioux Falls, South Dakota, the University of Iowa Hospitals and Clinics (Terveen), Iowa City, Iowa, Advanced Vision Care and Jules Stein Eye Institute (Fram), David Geffen School of Medicine, University of California, Los Angeles, California, the Cornea Service (Ayres), and Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

Purpose: To determine the visual outcomes and complications of a new small-incision technique for 4-point fixation of a hydrophilic acrylic posterior chamber intraocular lens (IOL) in the absence of capsule support.

Setting: Three North American tertiary referral centers and a private practice.

Design: Retrospective case series. Read More

Clin Optom (Auckl) 2016 31;8:23-35. Epub 2016 Mar 31.

Urgent Eye Care Service, Illinois College of Optometry, Chicago, IL, USA.

Anterior uveitis encompasses inflammation of the iris and/or ciliary body and is one of the most common types of ocular inflammation that primary eye care practitioners will encounter. Anterior uveitis may be caused by a variety of etiologies, including infectious, non-infectious, and masquerade diseases. The short-term and long-term treatment of uveitis should include the evaluation of location, duration, pathology, and laterality, in addition to presenting signs and symptoms of the disease. Read More

Duodecim 2016 ;132(4):377-82

Several new biological drugs, of which TNFα blockers are being used most extensively, have in recent years been adopted for the treatment of pediatric inflammatory diseases such as juvenile arthritis and associated chronic iritis, and inflammatory bowel diseases. In special situations the children will be prescribed off-label also other drugs affecting cytokines, e.g. Read More

Lakartidningen 2016 02 23;113. Epub 2016 Feb 23.

med dr, överläkare, Centralsjukhuset Karlstad - öron-, näsa- och halskliniken Karlstad, Sweden med dr, överläkare, Centralsjukhuset Karlstad - öron-, näsa- och halskliniken Karlstad, Sweden.

Cogans syndrome is a rare systemic inflammatory disease characterized by a combination of audiovestibular and ocular symptoms. In some cases, systemic complications occur with vascular inflammation. Aortitis and large vessel vasculitis are the most common forms, but medium-sized and small vessel involvement has also been described. Read More

Conn Med 2016 Jan;80(1):11-4

Sarcoidosisis amultisystemic granulomatous disease, potentially affecting any organ system of the body. Calcium metabolism disturbances occur in up to 20% of patients, of which hypercalciuria and asymptomatic hypercalcemia are most common. Ocular sarcoid typically presents with anterior chamber manifestations such as uveitis, iritis, and iridocyclitis, but can involve posterior chamber as well. Read More

Br J Ophthalmol 2016 08 30;100(8):1098-101. Epub 2015 Dec 30.

Department of Ophthalmology and Visual Neurosciences, University of Minnesota, Minneapolis, Minnesota, USA Department of Ophthalmology, State University of New York Downstate, Brooklyn, New York, USA.

Purpose: NewColorIris cosmetic iris implants have a record of high ocular morbidity and are no longer in use. Newer generation of iris implants, BrightOcular, have patented posterior grooves in order to decrease iris touch and facilitate aqueous flow around the implant. However, little is known about their safety despite their implantations in 10 countries. Read More

Nippon Ganka Gakkai Zasshi 2015 Oct;119(10):678-85

Purpose: To investigate a clinical survey of uveitis in Tokyo Medical and Dental University Hospital.

Subjects And Methods: The clinical records of patients with uveitis who were treated from October 1998 to December 2001 and from January 2007 to December 2011 were reviewed. The clinical results of both periods were compared. Read More

Zhongguo Zhen Jiu 2015 Jul;35(7):744

J Ophthalmic Inflamm Infect 2015 Dec 26;5(1):31. Epub 2015 Oct 26.

Department of Ophthalmology, Scheie Eye Institute, 51 N 39th St, Philadelphia, PA, 19104, USA.

A 79-year-old female with a 2-month history of newly diagnosed myelodysplastic syndrome for which she received blood transfusion with darbepoetin alfa presented with bilateral anterior uveitis 1 day after her fourth transfusion. On exam, visual acuity was 20/20 in both eyes with biomicroscopy notable for conjunctival injection and anterior chamber cell and flare consistent with anterior uveitis. She had no systemic symptoms, no history of eye trauma, and no known infections. Read More

Clin Ophthalmol 2015 5;9:1869-74. Epub 2015 Oct 5.

Department of Ophthalmology, University of Virginia, Charlottesville, VA, USA.

Purpose: The purpose of this study was to conduct an in-depth analysis of traumatic uveitis in patients managed in a mid-Atlantic tertiary care center with the goal of better characterizing the clinical features and outcomes of this large and important subset of uveitis patients.

Methods: This was a retrospective, observational study comparing traumatic uveitis patients with nontraumatic uveitis patients seen at the University of Virginia, Charlottesville, VA, USA, from 1984 to 2014.

Results: Fifty-four traumatic uveitis patients (55 eyes) were identified. Read More

Eye (Lond) 2016 Jan 16;30(1):164-5. Epub 2015 Oct 16.

Ophthalmology Department, Leeds Teaching Hospitals Trust, St James's University Hospital, Leeds, UK.

Eye (Lond) 2016 Jan 16;30(1):165. Epub 2015 Oct 16.

Princess Alexandra Eye Pavilion, Edinburgh, UK.

Bull Soc Pathol Exot 2015 Dec 29;108(5):312-5. Epub 2015 Sep 29.

Medical Biology Unit, Institut Pasteur du Cambodge, Phnom Penh, Cambodge.

A live intraocular nematode was identified from a 37 year-old man presented with iritis, pain, redness, lacrimation, swelling, vision loss and intermittent blindness during many hours per day of the left eye. By using slit lamp examination, a worm was removed from iris in an ophthalmology outpatient department setting and sent to the Medical Microbiology Laboratory, Institut Pasteur du Cambodge. Gnathostoma spinigerum was identified, based on its typical morphology via microscopic examination. Read More

Jpn J Ophthalmol 2016 Jan 14;60(1):1-6. Epub 2015 Sep 14.

Department of Medicine, Oregon Health and Science University, Portland, OR, 97239, USA.

An understanding of the microbiome is emerging as an exciting and novel way to elucidate the regulation of the immune system. Since the immune system plays a major role in the pathogenesis of many diseases including most forms of uveitis, it is critical to clarify the relationship between our immune system and the commensal bacteria that coexist in every human being. Read More

Cornea 2015 Nov;34(11):1513-5

*Department of Ophthalmology, University of California, San Francisco, San Francisco, CA; and †Francis I. Proctor Foundation, University of California, San Francisco, San Francisco, CA; A. Delwig is now with SiteOne Therapeutics, San Francisco, CA; and T. P. Margolis is now with the Department of Ophthalmology, Washington University, Saint Louis, MO.

Purpose: To report the use of topical valganciclovir for the treatment of hypertensive anterior uveitis associated with clinical signs of cytomegalovirus (CMV) iritis.

Methods: A case report and review of the literature.

Results: A 37-year-old man was referred with a unilateral hypertensive anterior uveitis with keratic precipitates suggestive of CMV as the causative agent. Read More

Optom Vis Sci 2015 Oct;92(10):e368-70

*MD †MD, PhD Ophthalmology Department, Complejo Hospitalario de Pontevedra, Pontevedra, Spain (AP-F); and Clínica Oftalmológica Dr Parafita, Santa Eugenia de Ribeira, Spain (MAP).

Purpose: Bacille Calmette-Guérin (BCG) is a vaccine that can be instilled into the urinary bladder as immunotherapy against superficial bladder cancer. Several case reports have implicated intravesical BCG in the development of uveitis. Patients treated with BCG therapy may present with systemic symptoms resembling reactive arthritis and, less frequently, have ocular adverse effects including bilateral panuveitis or chorioretinitis. Read More

Arq Bras Oftalmol 2015 May-Jun;78(3):154-7

Department of Ophthalmology, School of Medicine, Necmettin Erbakan University, Konya, Turkey.

Purpose: To analyze the indications for explantation or exchange of intraocular lenses (IOLs), which were originally implanted for the correction of aphakia during cataract extraction.

Methods: All cases that involved intraocular lens explantation or exchange in one institution between January 2008 and December 2014 were analyzed retrospectively.

Results: In total, 93 eyes of 93 patients were analyzed. Read More

Eye (Lond) 2015 Nov 3;29(11):1438-41. Epub 2015 Jul 3.

Department of Ophthalmology, University of Iowa Hospitals and Clinics, Iowa City, IA, USA.

Purpose: To describe the safety and stability of sulcus placement of the MA50 intraocular lens (IOL).

Patients And Methods: Consecutive patients with MA50 IOLs placed in the sulcus at the University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA, from 1997 to 2012 were identified. Inclusion criteria included patients with over 4 weeks of follow-up data. Read More

Ophthalmologe 2015 Dec;112(12):1014-6

Universitätsklinikum Dokuz Eylül, Augenklinik, Izmir, Türkei.

Mil Med 2015 May;180(5):e622-5

U.S. Department of Veterans Affairs, Ocala Community Based Outpatient Clinic, 3307 SW 26th Avenue, Ocala, FL 34471.

Cutaneous leukocytoclastic vasculitis (LCV) is a systemic condition that can be associated with iritis. LCV is characterized as a small-vessel vasculitis of the cutaneous area. The disease demonstrates purple lesions on the skin due to the destruction of small cutaneous blood vessels. Read More

Optom Vis Sci 2015 May;92(5):e97-e105

*OD, DO, MS, FAAO †BA Department of Ophthalmology, Mayo Clinic Health System, Albert Lea, Minnesota (LS, Jr.); and Pacific University College of Optometry, Forest Grove, Oregon (LG).

Purpose: To present a case of neovascular age-related macular degeneration treated with aflibercept intravitreal injections after bilateral bevacizumab injections, administered on separate dates, resulted in bilateral iritis.

Case Report: A 73-year-old woman with a previous history of two episodes of nongranulomatous iritis in her right eye that was believed to be associated with her systemic diagnosis of rheumatoid arthritis was treated with intravitreal bevacizumab injections for bilaterally occurring neovascular age-related macular degeneration. Initial bevacizumab injections in each eye administered sequentially over a week's time resulted in immediate-onset nongranulomatous iritis in each eye. Read More

JAMA Ophthalmol 2015 Jun;133(6):723-4

Department of Ophthalmology and Visual Neurosciences, University of Minnesota, St Paul3Department of Ophthalmology, State University of New York Downstate, Brooklyn.