11,146 results match your criteria Irish Medical Times [Journal]


Fin whale (Balaenoptera physalus) mitogenomics: A cautionary tale of defining sub-species from mitochondrial sequence monophyly.

Mol Phylogenet Evol 2019 Feb 13. Epub 2019 Feb 13.

Marine Evolution and Conservation, Groningen Institute of Evolutionary Life Sciences, University of Groningen, Nijenborgh 7, 9747 AG, Groningen, The Netherlands; Center for Coastal Studies, 5 Holway Avenue, Provincetown, MA 02657, United States of America. Electronic address:

The advent of massive parallel sequencing technologies has resulted in an increase of studies based upon complete mitochondrial genome DNA sequences that revisit the taxonomic status within and among species. Spatially distinct monophyly in such mitogenomic genealogies, i.e. Read More

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http://dx.doi.org/10.1016/j.ympev.2019.02.003DOI Listing
February 2019

Acute multiple sclerosis lesion pathology does not predict subsequent clinical course-a biopsy study.

Ir J Med Sci 2019 Feb 15. Epub 2019 Feb 15.

Department of Neuropathology, Beaumont Hospital, Beaumont Road, Dublin, Ireland.

Background: Knowledge of the clinical outcome in tumefactive demyelination remains limited.

Aims: This study aims to characterise the natural history of biopsy-proven, pathogen-free, cerebral demyelination in an adult Irish population.

Methods: We identified all patients with biopsy-proven demyelination in a single neuropathology centre between 1999 and 2017. Read More

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http://dx.doi.org/10.1007/s11845-019-01983-zDOI Listing
February 2019

Increased galactose expression and enhanced clearance in patients with Low von Willebrand factor.

Blood 2019 Feb 15. Epub 2019 Feb 15.

Haemostasis Research Group, Department of Molecular and Cellular Therapeutics, Irish Centre for Vascular Biology, Royal College of Surgeons in Ireland, Dublin, Ireland.

Glycan determinants on von Willebrand factor (VWF) play critical roles in regulating its susceptibility to proteolysis and clearance. Abnormal glycosylation has been shown to cause VWD in a number of different mouse models. However, due to the significant technical challenges associated with accurate assessment of VWF glycan composition, the importance of carbohydrates in human VWD pathogenesis remains largely unexplored. Read More

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http://dx.doi.org/10.1182/blood-2018-09-874636DOI Listing
February 2019

Increased Leucocyte-Platelet Complex Formation in Recently Symptomatic versus Asymptomatic Carotid Stenosis Patients and in Micro-emboli Negative Subgroups.

Thromb Haemost 2019 Feb 15. Epub 2019 Feb 15.

Department of Neurology, Adelaide and Meath Hospital, Dublin, incorporating the National Children's Hospital (AMNCH)/Tallaght University Hospital, Dublin, Ireland.

Introduction:  Cerebral micro-embolic signals (MES) predict risk of stroke in carotid stenosis patients. However, MES-negative 'recently symptomatic patients' also have a higher stroke risk than 'asymptomatic patients'. Differences in platelet activation status may contribute to this disparity in risk. Read More

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http://dx.doi.org/10.1055/s-0039-1678666DOI Listing
February 2019

Psychometric Evaluation of a Measure of Factors Influencing Hand Hygiene Behaviour to Inform Intervention.

J Hosp Infect 2019 Feb 12. Epub 2019 Feb 12.

Irish Centre for Applied Patient Safety and Simulation, School of Medicine, National University of Ireland Galway, Ireland; Discipline of General Practice, School of Medicine, National University of Ireland Galway, Ireland. Electronic address:

Background: Although the hand hygiene (HH) procedure is simple, the related behaviour is complex and is not readily understood, explained, or changed. There is a need for practical tools to provide data that can guide healthcare managers and practitioners not only on the 'what' (the standards that must be met), but also the 'how' (guidance on how to achieve the standards).

Aim: To develop a valid questionnaire to evaluate attitudes to the factors that influence engagement in HH behaviour that can be readily completed, administered, and analysed by healthcare professionals to identify appropriate intervention strategies. Read More

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http://dx.doi.org/10.1016/j.jhin.2019.02.003DOI Listing
February 2019

Cognitive performance and functional outcomes of carriers of pathogenic copy number variants: analysis of the UK Biobank.

Br J Psychiatry 2019 Feb 15:1-8. Epub 2019 Feb 15.

Professor, Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics,Cardiff University,UK.

Background: Rare copy number variants (CNVs) are associated with risk of neurodevelopmental disorders characterised by varying degrees of cognitive impairment, including schizophrenia, autism spectrum disorder and intellectual disability. However, the effects of many individual CNVs in carriers without neurodevelopmental disorders are not yet fully understood, and little is known about the effects of reciprocal copy number changes of known pathogenic loci.AimsWe aimed to analyse the effect of CNV carrier status on cognitive performance and measures of occupational and social outcomes in unaffected individuals from the UK Biobank. Read More

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http://dx.doi.org/10.1192/bjp.2018.301DOI Listing
February 2019

The helminth parasite community of European badgers (Meles meles) in Ireland.

J Helminthol 2019 Feb 15:1-4. Epub 2019 Feb 15.

Department of Zoology, School of Natural Sciences, Trinity College Dublin,Ireland.

The European badger (Meles meles) is Ireland's largest terrestrial carnivore. Since first being identified as a wildlife reservoir of bovine tuberculosis in 1974 there has been an increased research focus into the behaviour of these ecologically important mammals in the Republic of Ireland (ROI). However, to date there has never been an assessment of the helminth parasite community of Irish badgers. Read More

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http://dx.doi.org/10.1017/S0022149X19000051DOI Listing
February 2019

The European Alpha-1 Research Collaboration (EARCO): a new ERS Clinical Research Collaboration to promote research in alpha-1 antitrypsin deficiency.

Eur Respir J 2019 Feb 14;53(2). Epub 2019 Feb 14.

Dept of Medicine, Pulmonary and Critical Care Medicine, University Medical Centre Giessen and Marburg, Philipps-University, Member of the German Centre for Lung Research (DZL), Marburg, Germany.

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http://dx.doi.org/10.1183/13993003.00138-2019DOI Listing
February 2019

Over prescribing of antibiotics for acute respiratory tract infections; a qualitative study to explore Irish general practitioners' perspectives.

BMC Fam Pract 2019 Feb 14;20(1):27. Epub 2019 Feb 14.

Graduate Entry Medical School, University of Limerick, Limerick, Ireland.

Background: Anti-microbial resistance (AMR) is a global threat to public health and antibiotics are often unnecessarily prescribed for acute respiratory tract infections (ARTIs) in general practice. We aimed to investigate why general practitioners (GPs) continue to prescribe antibiotics for ARTIs despite increasing knowledge of their poor efficacy and worsening antimicrobial resistance.

Methods: We used an explorative qualitative study design. Read More

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http://dx.doi.org/10.1186/s12875-019-0917-8DOI Listing
February 2019

A randomised controlled trial of the Group Stepping Stones Triple P training programme for parents of children with developmental disabilities.

Clin Child Psychol Psychiatry 2019 Feb 15:1359104519827622. Epub 2019 Feb 15.

2 Health Service Executive, Ireland.

The central aim of this study was to examine the effectiveness of Group Stepping Stones Triple P (GSSTP) in an Irish context for families of children with both developmental disabilities and internalising and externalising behavioural problems. Parents of 84 children (mean age = 5.73; SD = 2. Read More

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http://dx.doi.org/10.1177/1359104519827622DOI Listing
February 2019

Mercury concentrations in marine species from the Aleutian Islands: Spatial and biological determinants.

Sci Total Environ 2019 Jan 31;664:761-770. Epub 2019 Jan 31.

Department of Veterinary Medicine, University of Alaska Fairbanks, 901 Koyukuk Drive, Fairbanks, AK 99775-7750, USA.

Several species found in the Bering Sea show significant spatial variation in total mercury concentrations ([THg]) longitudinally along the Aleutian Island chain. We assessed [THg] in other members of the Bering Sea food web to better understand the factors shaping regional differences. [THg] and stable carbon and nitrogen isotope ratios (δN and δC values) were measured in muscle tissue from 1052 fishes and cephalopods from parts of the Bering Sea and North Pacific Ocean adjacent to the Aleutian Islands. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.01.387DOI Listing
January 2019

Variance components for bovine tuberculosis infection and multi-breed genome-wide association analysis using imputed whole genome sequence data.

PLoS One 2019 14;14(2):e0212067. Epub 2019 Feb 14.

Teagasc, Animal and Grassland Research and Innovation Centre, Moorepark, Fermoy, Co. Cork, Ireland.

Bovine tuberculosis (bTB) is an infectious disease of cattle generally caused by Mycobacterium bovis, a bacterium that can elicit disease humans. Since the 1950s, the objective of the national bTB eradication program in Republic of Ireland was the biological extinction of bTB; that purpose has yet to be achieved. Objectives of the present study were to develop the statistical methodology and variance components to undertake routine genetic evaluations for resistance to bTB; also of interest was the detection of regions of the bovine genome putatively associated with bTB infection in dairy and beef breeds. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212067PLOS
February 2019

Challenges and supports towards the integration of ePortfolios in education. Lessons to be learned from Ireland.

Heliyon 2018 Nov 30;4(11):e00899. Epub 2018 Nov 30.

EQI, The Centre for Evaluation, Quality and Inspection, DCU Institute of Education, Ireland.

This paper reports on research derived from a one-year study on the integration of ePortfolios in education using Ireland as a case example. Through a series of interviews with school principals, teachers and members of the support service of the Department of Education and Skills in Ireland, this research explores the opportunities and challenges relating to the use of ePortfolios in Irish post-primary education. Evidence suggests that, whilst supports for the integration of ePortfolios are beginning to emerge, there are many unresolved issues. Read More

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http://dx.doi.org/10.1016/j.heliyon.2018.e00899DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6275690PMC
November 2018

Extracranial and Intracranial Vasculopathy With "Moyamoya Phenomenon" in Association With Alagille Syndrome.

Front Neurol 2018 29;9:1194. Epub 2019 Jan 29.

Department of Neurology, The Adelaide and Meath Hospital, Dublin, Incorporating The National Children's Hospital (AMNCH)/Tallaght University Hospital, Dublin, Ireland.

Alagille syndrome (AGS) is an autosomal-dominant, multisystem disorder caused by mutations in the JAG1 gene. A 34-year-old man was referred to our service 10 years ago with focal seizures with impaired awareness and transient slurred speech. He had a 5-year history of intermittent left monocular low-flow retinopathy. Read More

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http://dx.doi.org/10.3389/fneur.2018.01194DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362309PMC
January 2019

Risk Perceptions Toward Drinking Water Quality Among Private Well Owners in Ireland: The Illusion of Control.

Risk Anal 2019 Feb 13. Epub 2019 Feb 13.

School of Earth Sciences, University College Dublin, Dublin, Ireland.

In rural areas where no public or group water schemes exist, groundwater is often the only source of drinking water and is extracted by drilling private wells. Typically, private well owners are responsible for the quality and testing of their own drinking water. Previous studies indicate that well owners tend to underestimate the risks of their well water being contaminated, yet little is known about why this is the case. Read More

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http://dx.doi.org/10.1111/risa.13283DOI Listing
February 2019

'We are the change' - An innovative community-based response to address self-stigma: A pilot study focusing on people living with HIV in Zimbabwe.

PLoS One 2019 13;14(2):e0210152. Epub 2019 Feb 13.

RCSI Institute of Leadership, Royal College of Surgeons in Ireland, Dublin, Ireland.

Introduction: Self-stigma-negative self-judgements resulting in shame, worthlessness and self-blame-may play a crucial role in emotional reactions and cause emotional distress among many people living with HIV and other chronic illnesses. Furthermore, self-stigma negatively impacts on self-agency, quality of life, adherence to treatment, and access to services. High levels of self-stigma have been reported across many countries, however few programmes or interventions exist to specifically tackle this phenomenon. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0210152PLOS
February 2019

Moderate-intensity aerobic and resistance exercise is safe and favorably influences body composition in patients with quiescent Inflammatory Bowel Disease: a randomized controlled cross-over trial.

BMC Gastroenterol 2019 Feb 12;19(1):29. Epub 2019 Feb 12.

Department of Medicine, National University of Ireland, University College Cork, Cork University Hospital, Wilton, T12 DC4A, Cork, Ireland.

Background: Overweight and metabolic problems now add to the burden of illness in patients with Inflammatory Bowel Disease. We aimed to determine if a program of aerobic and resistance exercise could safely achieve body composition changes in patients with Inflammatory Bowel Disease.

Methods: A randomized, cross-over trial of eight weeks combined aerobic and resistance training on body composition assessed by Dual Energy X-ray Absorptiometry was performed. Read More

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http://dx.doi.org/10.1186/s12876-019-0952-xDOI Listing
February 2019

Thromboprophylaxis for varicose vein procedures - A national survey.

Phlebology 2019 Feb 12:268355519828931. Epub 2019 Feb 12.

Department of Vascular Surgery, Royal Victoria Hospital, Belfast, UK.

Background: Venous thromboembolism is rare following varicose vein ablation procedures, but uncertainty about its incidence combined with a lack of evidence-based clinical guidelines regarding thromboprophylaxis has led to debate about best practice. We conducted a national survey to investigate current practice among Irish vascular surgeons.

Methods: An anonymous online questionnaire was emailed to all members of the Irish Association of Vascular Surgeons and the Northern Ireland Vascular Society. Read More

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http://dx.doi.org/10.1177/0268355519828931DOI Listing
February 2019

Does locally delivered small group continuing medical education (CME) meet the learning needs of rural general practitioners?

Educ Prim Care 2019 Feb 12:1-7. Epub 2019 Feb 12.

a Health Sciences Centre, UCD , University College Dublin School of Medicine , West Waterford , Ireland.

The World Health Organisation policy of improving retention of rural health care practitioners recommended that continuing medical education (CME) programmes addressing their needs should be accessible and delivered where they live and work. This cross-sectional study involved a self-administered anonymous questionnaire completed by GPs attending CME small groups (CME-SGL) in Ireland. All GPs attending CME-SGL in a one-month period were invited to complete the questionnaire which examined demographic details, distance to travel to educational meetings/nearest regional hospital, barriers to accessing continuing education, whether CME-SGL met their educational needs, morale and professional isolation. Read More

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http://dx.doi.org/10.1080/14739879.2019.1573109DOI Listing
February 2019

Cryptic diets of forage fish: jellyfish consumption observed in the Celtic Sea and western English Channel.

J Fish Biol 2019 Feb 12. Epub 2019 Feb 12.

School of Biological Sciences, University of East Anglia, Norfolk, UK.

To establish if fishes' consumption of jellyfish changes through the year, we conducted a molecular gut-content assessment on opportunistically sampled species from the Celtic Sea in October and compared these with samples previously collected in February and March from the Irish Sea. Mackerel Scomber scombrus were found to feed on hydrozoan jellyfish relatively frequently in autumn, with rare consumption also detected in sardine Sardina pilchardus and sprat Sprattus sprattus. By October, moon jellyfish Aurelia aurita appeared to have escaped predation, potentially through somatic growth and the development of stinging tentacles. Read More

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http://dx.doi.org/10.1111/jfb.13926DOI Listing
February 2019

The relationship between IGF-I and -II concentrations and body composition at birth and over the first 2 months.

Pediatr Res 2019 Feb 11. Epub 2019 Feb 11.

The Irish Centre for Fetal and Neonatal Translational Research, Cork, Ireland.

Background: Insulin-like growth factor (IGF)-I and -II play an important role in prenatal growth. During the first 2 months from birth, body fat doubles, and rapid weight gain during this time increases future risk of cardiometabolic disease.

Objective: To determine whether IGF measurements at birth associate with body composition and the trajectory of its changes in the first 2 months. Read More

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http://dx.doi.org/10.1038/s41390-019-0331-xDOI Listing
February 2019

Education from other journals #12.

Br J Sports Med 2019 Feb 11. Epub 2019 Feb 11.

Glen Sather Sports Medicine Clinic, Edmonton, Alberta, Canada.

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http://dx.doi.org/10.1136/bjsports-2018-100283DOI Listing
February 2019
1 Read

"Do as we say, not as we do?" the lifestyle behaviours of hospital doctors working in Ireland: a national cross-sectional study.

BMC Public Health 2019 Feb 11;19(1):179. Epub 2019 Feb 11.

Research Department, Royal College of Physicians of Ireland, Dublin, Ireland.

Background: This study was conducted to assess the lifestyle behaviours of a national sample of hospital doctors working in Ireland. We also sought to compare the prevalence of these behaviours in doctors to the general Irish population.

Methods: This was a national cross-sectional study of a randomised sample of hospital doctors working in Irish publicly funded hospitals and residential institutions. Read More

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http://dx.doi.org/10.1186/s12889-019-6451-8DOI Listing
February 2019

HER2-Targeted Tyrosine Kinase Inhibitors Cause Therapy-Induced-Senescence in Breast Cancer Cells.

Cancers (Basel) 2019 Feb 8;11(2). Epub 2019 Feb 8.

Molecular Therapeutics for Cancer Ireland, National Institute for Cellular Biotechnology, Dublin City University, Glasnevin, 9 Dublin, Ireland.

Prolonged treatment of HER2 positive breast cancer cells with tyrosine kinase inhibitors (TKIs) leads to the emergence of acquired resistance. However, the effects of continuous TKI exposure on cell fate, and the steps leading to the acquisition of a resistant phenotype are poorly understood. To explore this, we exposed five HER2 positive cells lines to HER2 targeted therapies for periods of up to 4 weeks and examined senescence associated β-galactosidase (SA-β-gal) activity together with additional markers of senescence. Read More

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http://dx.doi.org/10.3390/cancers11020197DOI Listing
February 2019
1 Read

Maternal body mass index, gestational weight gain, and the risk of overweight and obesity across childhood: An individual participant data meta-analysis.

PLoS Med 2019 Feb 11;16(2):e1002744. Epub 2019 Feb 11.

The Generation R Study Group, Erasmus University Medical Center, Rotterdam, the Netherlands.

Background: Maternal obesity and excessive gestational weight gain may have persistent effects on offspring fat development. However, it remains unclear whether these effects differ by severity of obesity, and whether these effects are restricted to the extremes of maternal body mass index (BMI) and gestational weight gain. We aimed to assess the separate and combined associations of maternal BMI and gestational weight gain with the risk of overweight/obesity throughout childhood, and their population impact. Read More

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http://dx.plos.org/10.1371/journal.pmed.1002744
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http://dx.doi.org/10.1371/journal.pmed.1002744DOI Listing
February 2019
4 Reads

EuGMS Task and Finish group on Fall-Risk-Increasing Drugs (FRIDs): Position on Knowledge Dissemination, Management, and Future Research.

Drugs Aging 2019 Feb 11. Epub 2019 Feb 11.

Department of Internal Medicine, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands.

Falls are a major public health concern in the older population, and certain medication classes are a significant risk factor for falls. However, knowledge is lacking among both physicians and older people, including caregivers, concerning the role of medication as a risk factor. In the present statement, the European Geriatric Medicine Society (EuGMS) Task and Finish group on fall-risk-increasing drugs (FRIDs), in collaboration with the EuGMS Special Interest group on Pharmacology and the European Union of Medical Specialists (UEMS) Geriatric Medicine Section, outlines its position regarding knowledge dissemination on medication-related falls in older people across Europe. Read More

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http://dx.doi.org/10.1007/s40266-018-0622-7DOI Listing
February 2019
1 Read

The Road to Improving Access to Surgical Specialist Consultations: Ontario's Experience with Wait 1 Wait Time Data.

Healthc Q 2018 Oct;21(3):42-50

Was born and educated in Alberta but moved to Ontario for his postgraduate training in orthopedic surgery at the University of Toronto. He has occupied a number of positions at St. Michael's Hospital, including surgeon-in-chief and medical director of the Trauma Program, and completed 10 years as professor and chairman, Division of Orthopaedic Surgery at University of Toronto. In 2006, Dr. Waddell became the provincial lead for orthopaedic surgery for Access to Care and is responsible for the Orthopaedic Surgery Wait Times portfolio.

In 2009, the Ontario Ministry of Health and Long-Term Care engaged Cancer Care Ontario to expand the Wait Time Information System to capture surgical consultation data (Wait 1). Over the years, an increasing number of patient and provider reports have shown that Wait 1 wait times account for a significant portion of the total wait time for surgery. With data published online by the ministry in late summer 2017, patients were given access to consultation wait time information for over 200 types of procedures at 92 surgical facilities in Ontario. Read More

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http://dx.doi.org/10.12927/hcq.2018.25701DOI Listing
October 2018

Prescriber Variation in Relation to Prescribing Trends within the Preferred Drugs Initiative in Ireland (2012-2015): An Interrupted Time Series Study Using Latent Curve Models.

Med Decis Making 2019 Feb 9:272989X18818165. Epub 2019 Feb 9.

Health Research Board (HRB) Centre for Primary Care Research, Department of General Practice, Royal College of Surgeons in Ireland Medical School, Dublin 2, Ireland.

Objectives: To examine the impact of the Preferred Drugs Initiative (PDI), an Irish health policy aimed at reducing prescribing variation.

Design: Interrupted time series spanning 2012 to 2015.

Setting: Health Service Executive pharmacy claims data for General Medical Services (GMS) patients, approximately 40% of the Irish population. Read More

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http://dx.doi.org/10.1177/0272989X18818165DOI Listing
February 2019

Trends in road transport collision deaths in the Irish paediatric population: a retrospective review of mortality data, 1991-2015.

BMJ Paediatr Open 2019 23;3(1):e000361. Epub 2019 Jan 23.

RCSI Department of Paediatrics, Temple Street Children's University Hospital, Dublin, Ireland.

Objective: To establish the incidence of road transport collision (RTC) fatalities in the Irish paediatric population, examining trends in fatality rates over a period of 25 years, during which several national road safety interventions were implemented.

Study Design: Retrospective review of death registration details of children 0-19 years in Ireland between January 1991 and December 2015. Trends in mortality rates were investigated using average annual per cent change and Poisson regression analysis. Read More

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http://dx.doi.org/10.1136/bmjpo-2018-000361DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347854PMC
January 2019

Spatiotemporal analysis of prolonged and recurrent bovine tuberculosis breakdowns in Northern Irish cattle herds reveals a new infection hotspot.

Spat Spatiotemporal Epidemiol 2019 Feb 14;28:33-42. Epub 2018 Nov 14.

Veterinary Sciences Division, Agri-food and Biosciences Institute (AFBI), 12 Stoney Road, Stormont, Belfast BT4 3SD, UK; School of Biological Sciences, Queen's University Belfast, Belfast, UK.

Despite a state-led eradication programme, bovine tuberculosis (bTB) remains endemic in Northern Ireland (NI). Of particular concern are "chronic" prolonged and recurrent bTB breakdowns, which represent significant financial and administrative burdens. However, little is known regarding the spatiotemporal distribution of chronic breakdowns in NI. Read More

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http://dx.doi.org/10.1016/j.sste.2018.11.002DOI Listing
February 2019

GDPR: an impediment to research?

Ir J Med Sci 2019 Feb 8. Epub 2019 Feb 8.

Beaumont Hospital Ethics (Medical Research) Committee, Beaumont Hospital, Dublin, Ireland.

Background: The recent introduction of the General Data Protection Regulation and Health Research Regulations has been an area of significant concern for those engaged in clinical research. These European regulations, following subsequent interpretation by Ireland's Department of Health, now place Ireland in a unique position which differs substantially from other European countries and may prove a significant impediment to Irish clinical research, depriving Irish patients of timely access to potentially life-saving treatments and making Ireland less attractive to pharmaceutical companies engaged in this area. At the very least, the regulations, as applied in Ireland, will place a significant extra burden of work on Ireland's clinical researchers and at their worst will force individuals and institutions out of the clinical research field, which will result in significant loss to the Irish knowledge economy and lead to the detriment of patient care. Read More

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http://link.springer.com/10.1007/s11845-019-01980-2
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http://dx.doi.org/10.1007/s11845-019-01980-2DOI Listing
February 2019
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Comparing trap designs and methods for assessing density of synanthropic flies in Odisha, India.

Parasit Vectors 2019 Feb 7;12(1):75. Epub 2019 Feb 7.

Department of Disease Control, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK.

Background: There are many different traps available for studying fly populations. The aim of this study was to find the most suitable trap to collect synanthropic fly populations to assess the impact of increased latrine coverage in the state of Odisha, India.

Methods: Different baits were assessed for use in sticky pot traps (60% sucrose solution, 60 g dry sucrose, half a tomato and an non-baited control), followed by different colours of trap (blue versus yellow) and finally different types of trap (baited sticky pot trap versus sticky card traps). Read More

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http://dx.doi.org/10.1186/s13071-019-3324-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367737PMC
February 2019

Radiologist's views on anatomical knowledge amongst junior doctors and the teaching of anatomy in medical curricula.

Ann Anat 2019 Feb 4. Epub 2019 Feb 4.

Department of Anatomy, Trinity Biomedical Sciences Institute, School of Medicine, Trinity College Dublin, Dublin, Ireland. Electronic address:

Reduced teaching resources, increasing student numbers and congested medical curricula have reportedly led to reports of inadequate anatomical knowledge among newly qualified doctors, placing scrutiny on pre-clinical education. We wished to gauge the opinions of practicing radiologists on undergraduate anatomy education. Members of the Irish Faculty of Radiologists were invited to complete a questionnaire based on undergraduate anatomical education. Read More

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http://dx.doi.org/10.1016/j.aanat.2019.01.011DOI Listing
February 2019

Parental perspective on neonatal outcomes.

Authors:
Mandy Daly

BMJ Paediatr Open 2019 13;3(1):e000404. Epub 2019 Jan 13.

Director of Advocacy and Policy Making, Irish Neonatal Health Alliance, Bray, Ireland.

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http://dx.doi.org/10.1136/bmjpo-2018-000404DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340574PMC
January 2019

Variation in Nonmelanoma Skin Cancer Incidence by Treatment Modality Among Patients Receiving Multiple Kidney Transplants.

JAMA Dermatol 2019 Feb 6. Epub 2019 Feb 6.

Department of Nephrology and Kidney Transplantation, Beaumont Hospital Dublin, Ireland.

Importance: Existing data suggest that nonmelanoma skin cancer (NMSC) is more common in renal transplant recipients than in maintenance dialysis patients. However, whether the risk of NMSC varies as the treatment modality for end-stage kidney disease (ESKD) changes between dialysis and transplantation is not well described.

Objective: To determine whether the incidence of NMSC is attenuated during periods of graft loss with a return to dialysis in those who receive multiple kidney transplants. Read More

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http://dx.doi.org/10.1001/jamadermatol.2018.4660DOI Listing
February 2019
1 Read

Do Differences in Spatiotemporal Gait Parameters Predict the Risk of Developing Depression in Later Life?

J Am Geriatr Soc 2019 Feb 5. Epub 2019 Feb 5.

The Irish Longitudinal Study on Ageing Trinity College Dublin, Dublin, Ireland.

Background/objectives: There is growing interest in the association between gait disturbance and depression in later life. The aim of this study is to clarify the longitudinal relationship between specific gait parameters and incident depression within a population-representative sample of older people.

Design: Longitudinal analysis of spatiotemporal gait parameters at baseline (wave 1) and incident depression at 2 and 4 years (waves 2/3). Read More

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http://dx.doi.org/10.1111/jgs.15783DOI Listing
February 2019
2 Reads

TREatment of ATopic eczema (TREAT) Registry Taskforce: consensus on how and when to measure the core dataset for atopic eczema treatment research registries.

Br J Dermatol 2019 Feb 4. Epub 2019 Feb 4.

Unit for Population-Based Dermatology Research, St John's Institute of Dermatology, Guy's& St Thomas' NHS Foundation Trust and King's College London, London, UK.

Background: Comparative, real-life and long-term evidence on the effectiveness and safety of photo- and systemic therapy in moderate-to-severe atopic eczema (AE) is limited. Such data must come from well-designed prospective patient registries. Standardisation of data collection is needed for direct comparisons and data pooling. Read More

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http://dx.doi.org/10.1111/bjd.17715DOI Listing
February 2019

Effect of supplementation with -3 polyunsaturated fatty acids and/or β-glucans on performance, feeding behaviour and immune status of Holstein Friesian bull calves during the pre- and post-weaning periods.

J Anim Sci Biotechnol 2019 29;10. Epub 2019 Jan 29.

1School of Agriculture, Food Science and Veterinary Medicine, University College Dublin, Belfield, Dublin 4, Ireland.

Background: Previous research in both calves and other species has suggested -3 polyunsaturated fatty acids (PUFA) and β-glucans may have positive effects on immune function. This experiment measured performance, behaviour, metabolite and immunological responses to pre-weaning supplementation of dairy bull calves with -3 PUFA in the form of fish oil and β-glucans derived from seaweed extract. 44 Holstein Friesian bull calves, aged 13. Read More

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http://dx.doi.org/10.1186/s40104-019-0317-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350401PMC
January 2019
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Hippocampal atrophy and intrinsic brain network dysfunction relate to alterations in mind wandering in neurodegeneration.

Proc Natl Acad Sci U S A 2019 Feb 4. Epub 2019 Feb 4.

Brain and Mind Centre, University of Sydney, Sydney 2050, Australia;

Mind wandering represents the human capacity for internally focused thought and relies upon the brain's default network and its interactions with attentional networks. Studies have characterized mind wandering in healthy people, yet there is limited understanding of how this capacity is affected in clinical populations. This paper used a validated thought-sampling task to probe mind wandering capacity in two neurodegenerative disorders: behavioral variant frontotemporal dementia [(bvFTD); = 35] and Alzheimer's disease [(AD); = 24], compared with older controls ( = 37). Read More

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http://dx.doi.org/10.1073/pnas.1818523116DOI Listing
February 2019
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Learning about midwifery in another country from a distance: Evaluation of a virtual classroom learning session.

Nurse Educ Today 2019 Apr 28;75:47-52. Epub 2019 Jan 28.

Midwifery Programme, Department of Midwifery and Therapeutic Sciences, Faculty of Health, University College Copenhagen, Sigurdsgade 26, SIG.D022, 2200 København N, Denmark.

Background: Studying abroad promotes cultural awareness and understanding of different healthcare settings and practices but family or financial constraints prevent some students from taking advantage of these opportunities. We developed a virtual classroom learning session to give Danish and Irish midwifery students an opportunity to explore midwifery and maternity care in another country.

Objectives: To evaluate the content of midwifery students' chat room discussions about the differences in maternity and midwifery care during an international online learning session, and their opinions of the session. Read More

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http://dx.doi.org/10.1016/j.nedt.2019.01.007DOI Listing
April 2019
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The long-term outcomes following internal fixation for intracapsular hip fractures in an Irish tertiary referral centre.

Ir J Med Sci 2019 Feb 2. Epub 2019 Feb 2.

Department of Trauma and Orthopaedic Surgery, University Hospital Galway, Galway, Ireland.

Background: The burden associated with hip fractures is increasing worldwide. Arthroplasty procedures are more commonly performed for intracapsular fractures due to increased risk of compromise to the femoral head blood supply. However, we know from the Irish Hip Fracture Database that a significant proportion of these fractures undergo internal fixation. Read More

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http://dx.doi.org/10.1007/s11845-019-01972-2DOI Listing
February 2019
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Assisted ventilation in motor neurone disease during inpatient palliative care: barriers and utilisation.

BMJ Support Palliat Care 2019 Feb 2. Epub 2019 Feb 2.

Palliative Medicine, Velindre Cancer Centre, Cardiff, UK.

Objectives: An increasing number of patients with motor neuron disease (MND) in the UK and Ireland use assisted ventilation, and a small proportion of these use long-term tracheostomy ventilation (TV).1 2 NICE guidelines recommend that patients with MND should routinely receive specialist palliative care input.3 The aim was to establish the extent to which hospices and specialist palliative care units (SPCUs) in the UK and Ireland currently manage patients with MND using assisted ventilation especially TV and to identify any associated barriers. Read More

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http://dx.doi.org/10.1136/bmjspcare-2018-001672DOI Listing
February 2019
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An Irish National Diabetes in Pregnancy Audit: aiming for best outcomes for women with diabetes.

Diabet Med 2019 Feb 2. Epub 2019 Feb 2.

University Hospital Galway, Galway.

Aims: The purpose of this study was to identify the number of pregnancies affected by pre-gestational diabetes in the Republic of Ireland; to report on pregnancy outcomes and to identify areas for improvement in care delivery and clinical outcomes.

Methods: Healthcare professionals caring for women with pre-gestational diabetes during pregnancy were invited to participate in this retrospective study. Data pertaining to 185 pregnancies in women attending 15 antenatal centres nationally were collected and analysed. Read More

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http://dx.doi.org/10.1111/dme.13923DOI Listing
February 2019

Lymph-node-first Kawasaki disease and giant coronary artery aneurysm.

Authors:
Bazlin Ramly

BMJ Case Rep 2019 Feb 1;12(2). Epub 2019 Feb 1.

Paediatric Department, University Hospital Waterford, Waterford, Ireland.

A 8-year-old Irish ethnicity girl presented with 3 days of fever with right-sided neck swelling which was first thought as acute tonsillitis with right-sided lymphadenitis. She was started on intravenous antibiotics. At day 7 of illness, she was diagnosed to have Kawasaki disease with clinical and biochemical evidence. Read More

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http://casereports.bmj.com/lookup/doi/10.1136/bcr-2018-22689
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http://dx.doi.org/10.1136/bcr-2018-226897DOI Listing
February 2019
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Clinical and neuroimaging investigations of language disturbance in frontotemporal dementia-motor neuron disease patients.

J Neurol 2019 Feb 1. Epub 2019 Feb 1.

Brain and Mind Centre, The University of Sydney, Sydney, NSW, Australia.

This study systematically investigated the neuropsychological profile of language disturbance in frontotemporal dementia-motor neuron disease (FTD-MND) using a data-driven approach. Neuroanatomical correlates of language profiles were also examined. Patients with FTD-MND (N = 26), pure motor neuron disease (N = 34), progressive non-fluent aphasia (N = 30), semantic dementia (N = 17), and controls (N = 31) underwent comprehensive language assessments. Read More

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http://dx.doi.org/10.1007/s00415-019-09216-0DOI Listing
February 2019
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Fundamental Movement Skill Proficiency and Health Among a Cohort of Irish Primary School Children.

Res Q Exerc Sport 2019 Feb 1:1-12. Epub 2019 Feb 1.

a Cork Institute of Technology.

Purpose: This study aimed to investigate the relationship between fundamental movement skills (FMS) and markers of health among a cohort of Irish primary school children.

Methods: Participants (N = 296, mean age: 7.99 ± 2. Read More

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http://dx.doi.org/10.1080/02701367.2018.1563271DOI Listing
February 2019

The role of real-time PCR testing in the investigation of paediatric patients with community-onset osteomyelitis and septic arthritis.

Ir J Med Sci 2019 Jan 31. Epub 2019 Jan 31.

Irish Meningitis and Sepsis Reference Laboratory, Temple Street Children's University Hospital, Dublin 1, Ireland.

Background: Culture yield in osteomyelitis and septic arthritis is low, emphasising the role for molecular techniques.

Aims: The purpose of this study was to review the laboratory investigation of childhood osteomyelitis and septic arthritis.

Methods: A retrospective review was undertaken in an acute tertiary referral paediatric hospital from January 2010 to December 2016. Read More

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http://link.springer.com/10.1007/s11845-019-01973-1
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http://dx.doi.org/10.1007/s11845-019-01973-1DOI Listing
January 2019
3 Reads

High resolution mapping of a cold water coral mound.

Sci Rep 2019 Jan 31;9(1):1016. Epub 2019 Jan 31.

School of Biological, Earth & Environmental Sciences, University College Cork, Cork, Ireland.

Cold-water coral (CWC) mounds are biogenic, long-lived morphostructures composed primarily by scleractinian CWC's and hemipelagic sediments that form complex deep-sea microhabitats found globally but specifically along the European-Atlantic margin. In this work, high-resolution mapping was applied to identify individual organismal distribution and zonation across a CWC Piddington Mound within the Porcupine Seabight, Ireland Margin. Marine Object-Based Image Analysis (MOBIA) and different machine learning classification methods (decision tree, logistic regression, and deep neural network) were applied to a high-resolution (2 mm) reef-scale video mosaic and ROV-mounted multibeam data in order to provide new insights into the spatial organization of coral frameworks and environmental factors on CWC mounds. Read More

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http://dx.doi.org/10.1038/s41598-018-37725-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355845PMC
January 2019

Obstetrical Outcomes of Head and Neck (Nonthyroid) Cancers: A 27-Year Retrospective Series and Literature Review.

AJP Rep 2019 Jan 29;9(1):e15-e22. Epub 2019 Jan 29.

Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada.

 To describe the clinical presentation and obstetrical outcomes of nonthyroid head and neck cancers (HNCs), and to review literature on this rare condition in pregnancy.  Pregnant women with nonthyroid HNC were identified retrospectively from 1990 to 2017. Maternal, neonatal, pregnancy, and demographic data were collected. Read More

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http://dx.doi.org/10.1055/s-0039-1677876DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351273PMC
January 2019