11,344 results match your criteria Irish Medical News [Journal]


No time to delay reperfusion: a cross-sectional study of Primary Percutaneous Coronary Intervention times.

J Clin Nurs 2019 Apr 24. Epub 2019 Apr 24.

School of Nursing and Midwifery, Trinity College Dublin, 24 D'Olier Street, Dublin 2, D02T283, Ireland.

Aims And Objectives: To establish and report cross-sectional data of reperfusion times for emergency primary percutaneous coronary interventions (PPCI) and to examine factors associated with times to reperfusion.

Background: Rapid coronary reperfusion can salvage myocardial tissue, preserve left ventricular function and reduce mortality. PPCI is the gold standard of management. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jocn.14892
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http://dx.doi.org/10.1111/jocn.14892DOI Listing
April 2019
1 Read

The Cholecystectomy As A Day Case (CAAD) Score: A Validated Score of Preoperative Predictors of Successful Day-Case Cholecystectomy Using the CholeS Data Set.

World J Surg 2019 Apr 23. Epub 2019 Apr 23.

Trent Oesophago-Gastric Unit, Nottingham University Hospitals NHS Trust, Nottingham City Hospital, Hucknall Road, Nottingham, NG5 1PB, UK.

Background: Day-case surgery is associated with significant patient and cost benefits. However, only 43% of cholecystectomy patients are discharged home the same day. One hypothesis is day-case cholecystectomy rates, defined as patients discharged the same day as their operation, may be improved by better assessment of patients using standard preoperative variables. Read More

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http://dx.doi.org/10.1007/s00268-019-04981-5DOI Listing

Statins for primary prevention of cardiovascular disease: modelling guidelines and patient preferences based on an Irish cohort.

Br J Gen Pract 2019 Apr 23. Epub 2019 Apr 23.

Department of General Practice, Royal College of Surgeons in Ireland, and Health Research Board Centre for Primary Care Research, Dublin, Ireland.

Background: Changes in clinical guidelines for primary prevention of cardiovascular disease (CVD) have widened eligibility for statin therapy.

Aim: To illustrate the potential impacts of changes in clinical guidelines.

Design And Setting: Modelling the impacts of seven consecutive European guidelines based on a cohort of people aged ≥50 years from the Irish Longitudinal Study on Ageing. Read More

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http://dx.doi.org/10.3399/bjgp19X702701DOI Listing

A Study of Traveller Horse Owners' Attitudes to Horse Care and Welfare Using an Equine Body Condition Scoring System.

Animals (Basel) 2019 Apr 12;9(4). Epub 2019 Apr 12.

Royal (Dick) School of Veterinary Studies, Easter Bush, Midlothian EH25 9RG, UK.

Traveller horses are often perceived to be exposed to poor welfare due to Travellers' traditional way of horsemanship. However, few studies have investigated Traveller horse welfare. Hence, the present study aims to explore Traveller horse owners' attitudes to horse care and welfare. Read More

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http://dx.doi.org/10.3390/ani9040162DOI Listing

Influence of Supplemental Feed Choice for Pasture-Based Cows on the Fatty Acid and Volatile Profile of Milk.

Foods 2019 Apr 22;8(4). Epub 2019 Apr 22.

Teagasc Animal and Grassland Research, Moorepark Fermoy, P61 C996 Co. Cork, Ireland.

The purpose of this study was to examine the impact of a variety of supplemental feeds on the composition and quality of milk in a pasture-based dairy system. Four pasture-supplemented feeding systems were compared: Group 1 supplementation with 16% crude protein parlour concentrate (CONC); Group 2 supplementation with palm kernel expeller plus parlour concentrate (PKE); Group 3 supplemented with soya hulls plus parlour concentrate (SOYA); Group 4 was supplemented with molassed beet pulp plus parlour concentrate (BEET). Supplemental feeding system was demonstrated to have a significant effect on the size of native casein micelles and the gelation properties of milks. Read More

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http://dx.doi.org/10.3390/foods8040137DOI Listing

Urospermia indicating ectopic ureters in breeding dogs - 3 cases.

Tierarztl Prax Ausg K Kleintiere Heimtiere 2019 Apr 23;47(2):119-124. Epub 2019 Apr 23.

Evidensia Veterinary Clinic for Small Animals Norderstedt.

An Entlebucher Mountain Dog (57 months old, case 1), a Labrador Retriever (24 months, case 2) and an Irish Soft-Coated Wheaten Terrier (31 months old, case 3) were presented for breeding soundness evaluation to the clinic. During semen collection in all 3 dogs, the pre-secretion and the sperm-rich fraction showed normal consistency and colour, whereas the prostatic secretion (3 rd ejaculate fraction) appeared strikingly yellow. In cases 1 and 2, a severely decreased sperm motility (asthenozoospermia) and an increased amount of abnormal spermatozoa (teratozoospermia), and in case 3, a moderately decreased total sperm count (oligozoospermia) were detected. Read More

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http://dx.doi.org/10.1055/a-0862-5443DOI Listing

Mental health patients' experiences of softer coercion and its effects on their interactions with practitioners: a qualitative evidence synthesis.

J Adv Nurs 2019 Apr 22. Epub 2019 Apr 22.

Department of Health Sciences, University of York.

Aims: To synthesize qualitative evidence of mental health patients' treatment-related experiences of softer coercion and its effect on their interactions with practitioners.

Background: Coercion is controversial but global in mental healthcare. It ranges from softer to harder forms, but less attention is given in the literature to softer coercion. Read More

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http://dx.doi.org/10.1111/jan.14035DOI Listing

The Use of Cardiotonic Drugs in Neonates.

Clin Perinatol 2019 Jun 30;46(2):273-290. Epub 2019 Mar 30.

Brighton and Sussex Medical School, University of Sussex, Brighton, UK; Department of Neonatology, Brighton & Sussex University Hospitals NHS Trust, Brighton, UK.

There is a distinct lack of age-appropriate cardiotonic drugs, and adult derived formulations continue to be administered, without evidence-based knowledge on their dosing, safety, efficacy, and long-term effects. Dopamine remains the most commonly studied and prescribed cardiotonic drug in the neonatal intensive care unit (NICU), but evidence of its effect on endorgan perfusion still remains. Unlike adult and pediatric critical care, there are significant gaps in our knowledge on the use of various cardiotonic drugs in various forms of circulatory failure in the NICU. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00955108193002
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http://dx.doi.org/10.1016/j.clp.2019.02.010DOI Listing
June 2019
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A comparison of service organisation and guideline compliance between two adjacent European health services.

Eur Stroke J 2017 Sep 30;2(3):238-243. Epub 2017 Mar 30.

National Clinical Programme for Stroke, Health Service Executive, Ireland.

Introduction: Outcomes in stroke patients are improved by a co-ordinated organisation of stroke services and provision of evidence-based care. We studied the organisation of care and application of guidelines in two neighbouring health care systems with similar characteristics.

Methods: Organisational elements of the 2015 National Stroke Audit (NSA) from the Republic of Ireland (ROI) were compared with the Sentinel Stroke National Audit Programme (SSNAP) in Northern Ireland (NI) and the United Kingdom (UK). Read More

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http://dx.doi.org/10.1177/2396987317703209DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454828PMC
September 2017
1 Read

Abnormal orthostatic blood pressure control among subjects with lacunar infarction.

Eur Stroke J 2016 Sep 4;1(3):222-230. Epub 2016 Aug 4.

Department of Medical Gerontology, Trinity College, Dublin, Ireland.

Introduction: Hypertension is a recognised risk factor for lacunar stroke. However, their association has been evaluated using static blood pressure (BP) assessment in supine or sitting position alone. We hypothesised that impaired dynamic (orthostatic) BP control may associate with lacunar strokes. Read More

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http://dx.doi.org/10.1177/2396987316663287DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6301241PMC
September 2016

Socioeconomic position, lifestyle habits and biomarkers of epigenetic aging: a multi-cohort analysis.

Aging (Albany NY) 2019 Apr;11(7):2045-2070

See ACKNOWLEDGMENTS AND FUNDING.

Differences in health status by socioeconomic position (SEP) tend to be more evident at older ages, suggesting the involvement of a biological mechanism responsive to the accumulation of deleterious exposures across the lifespan. DNA methylation (DNAm) has been proposed as a biomarker of biological aging that conserves memory of endogenous and exogenous stress during life.We examined the association of education level, as an indicator of SEP, and lifestyle-related variables with four biomarkers of age-dependent DNAm dysregulation: the total number of stochastic epigenetic mutations (SEMs) and three epigenetic clocks (Horvath, Hannum and Levine), in 18 cohorts spanning 12 countries. Read More

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http://dx.doi.org/10.18632/aging.101900DOI Listing
April 2019
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Drip and ship versus direct to endovascular thrombectomy: The impact of treatment times on transport decision-making.

Eur Stroke J 2018 Jun 14;3(2):126-135. Epub 2018 Feb 14.

Beaumont Hospital, Dublin, Ireland.

Introduction: In ischaemic stroke care, fast reperfusion is essential for disability free survival. It is unknown if bypassing thrombolysis centres in favour of endovascular thrombectomy (mothership) outweighs transport to the nearest thrombolysis centre for alteplase and then transfer for endovascular thrombectomy (drip-and-ship). We use conditional probability modelling to determine the impact of treatment times on transport decision-making for acute ischaemic stroke. Read More

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http://dx.doi.org/10.1177/2396987318759362DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460407PMC

Using a Scenario-Neutral Framework to Avoid Potential Maladaptation to Future Flood Risk.

Water Resour Res 2019 Feb 7;55(2):1079-1104. Epub 2019 Feb 7.

Flood Relief and Risk Management Division, Office of Public Works Trim Ireland.

This study develops a coherent framework to detect those catchment types associated with a high risk of maladaptation to future flood risk. Using the "scenario-neutral" approach to impact assessment the sensitivity of Irish catchments to fluvial flooding is examined in the context of national climate change allowances. A predefined sensitivity domain is used to quantify flood responses to +2 °C mean annual temperature with incremental changes in the seasonality and mean of the annual precipitation cycle. Read More

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http://dx.doi.org/10.1029/2018WR023623DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472323PMC
February 2019

Educational attainment of childhood cancer survivors: A systematic review.

Cancer Med 2019 Apr 21. Epub 2019 Apr 21.

Institute of Health & Society, Newcastle University, Newcastle upon Tyne, United Kingdom.

Background: Advances in treatment mean that most children diagnosed with cancer during childhood survive. Therefore, it is increasingly important to examine the long-term consequences of childhood cancer, including educational attainment. This systematic review investigated whether the educational attainment of childhood cancer survivors differ from the cancer-free population. Read More

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http://dx.doi.org/10.1002/cam4.2154DOI Listing
April 2019
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Beyond the borderline.

Lancet Psychiatry 2019 May;6(5):371-372

Cassel Hospital, Richmond, UK; co-President, British and Irish Group for the Study of Personality Disorder.

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https://linkinghub.elsevier.com/retrieve/pii/S22150366193013
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http://dx.doi.org/10.1016/S2215-0366(19)30133-6DOI Listing
May 2019
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A review of reproductive outcomes of women with two consecutive miscarriages and no living child.

J Obstet Gynaecol 2019 Apr 22:1-6. Epub 2019 Apr 22.

a Department of Obstetrics and Gynaecology , University College Cork , Cork , Ireland.

The definition of recurrent miscarriage ranges from two miscarriages according to the American Society for Reproductive Medicine and the European Society of Human Reproduction and Embryology, to three consecutive pregnancy losses as defined by the Royal College of Obstetricians and Gynaecologists. Recent guidelines emphasise the need for further research on the effect of various recurrent miscarriage definitions on diagnosis, treatment and prognosis. Our study examines the management and pregnancy outcomes of nulliparous women attending Cork University Maternity Hospital's Pregnancy Loss Clinic, between 2009 and 2014, with their second consecutive first-trimester miscarriage. Read More

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https://www.tandfonline.com/doi/full/10.1080/01443615.2019.1
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http://dx.doi.org/10.1080/01443615.2019.1576600DOI Listing
April 2019
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Molecular signature characterisation of different inflammatory phenotypes of systemic juvenile idiopathic arthritis.

Ann Rheum Dis 2019 Apr 20. Epub 2019 Apr 20.

Department of Paediatric Rheumatology and Immunology, University of Münster, Münster, Germany

Objectives: The International League of Associations for Rheumatology classification criteria define systemic juvenile idiopathic arthritis (SJIA) by the presence of fever, rash and chronic arthritis. Recent initiatives to revise current criteria recognise that a lack of arthritis complicates making the diagnosis early, while later a subgroup of patients develops aggressive joint disease. The proposed biphasic model of SJIA also implies a 'window of opportunity' to abrogate the development of chronic arthritis. Read More

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http://ard.bmj.com/lookup/doi/10.1136/annrheumdis-2019-21505
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http://dx.doi.org/10.1136/annrheumdis-2019-215051DOI Listing
April 2019
1 Read

The effect of growth rate on reproductive outcomes in replacement dairy heifers in seasonally calving, pasture-based systems.

J Dairy Sci 2019 Apr 17. Epub 2019 Apr 17.

University College Dublin, Belfield, Dublin 4, Ireland D04V1W8.

The effect of average daily gain (ADG) on reproductive outcomes in replacement dairy heifers was investigated. All heifers were managed in the typical Irish spring calving, pasture-based system, where the herd calves in 1 block between January and April and the majority of the diet comprises grazed grass. Heifer calves (n = 399) from 7 herds were weighed at birth and at the beginning of the breeding season, and ADG was calculated. Read More

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http://dx.doi.org/10.3168/jds.2018-16079DOI Listing

Validation of distant metastases risk-groups in oral cavity squamous cell carcinoma patients treated with postoperative intensity-modulated radiotherapy.

Radiother Oncol 2019 May 31;134:10-16. Epub 2019 Jan 31.

Department of Radiation Oncology, Princess Margaret Cancer Centre/University of Toronto, Canada. Electronic address:

Background: This study aimed to derive distant metastases (DM) risk-groups in oral cavity squamous cell carcinoma (OSCC) patients treated with postoperative intensity-modulated radiation therapy (PO-IMRT).

Methods: OSCC patients treated with PO-IMRT were divided into discovery (2005-2012) and validation (2013-2014) cohorts. DM predictors were identified from multivariable analysis (MVA) to derive low- and high-risk groups in the discovery-cohort. Read More

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http://dx.doi.org/10.1016/j.radonc.2019.01.014DOI Listing
May 2019
4.363 Impact Factor

The Association of Tacrolimus Formulation Switching with Trough Concentration Variability: A Retrospective Cohort Study of Tacrolimus Use Post-Kidney Transplantation Based on National Drug Code (NDC) Numbers.

Adv Ther 2019 Apr 19. Epub 2019 Apr 19.

Formerly Real World Evidence, CTI Clinical Trial and Consulting Services, Raleigh, NC, USA.

Introduction: It was hypothesized that patients experiencing at least one tacrolimus formulation switch may require more frequent therapeutic drug monitoring, subsequent dose adjustments, and a potential for untoward clinical outcomes than patients who remain on a single formulation.

Methods: Eligible patients were adult kidney transplant recipients with stable renal function at month 3 post-transplant and no evidence of acute rejection, receiving an oral, tacrolimus-based regimen. Patients were categorized into two groups (fixed or variable formulation) using the US National Drug Code (NDC) on the basis of tacrolimus formulation usage over the 12-month period. Read More

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http://dx.doi.org/10.1007/s12325-019-00950-5DOI Listing
April 2019
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A 5-year review of a pitch side radiology unit at an international sports stadium.

Ir J Med Sci 2019 Apr 17. Epub 2019 Apr 17.

Department of Radiology, Mater Misericordiae University Hospital, Dublin 7, Ireland.

Background: The increased strength and conditioning of elite athletes has led to greater potential for high impact injuries. With increasing concerns for player welfare, the decision to return to play after sustaining an on-field injury is complex.

Aim: Review of a 5-year experience of a pitch side radiology unit (PSRU) at a large international sports stadium. Read More

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http://link.springer.com/10.1007/s11845-019-02013-8
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http://dx.doi.org/10.1007/s11845-019-02013-8DOI Listing
April 2019
2 Reads

Smartphone and video game use and perceived effects in a community mental health service.

Ir J Med Sci 2019 Apr 17. Epub 2019 Apr 17.

Cluain Mhuire Community Mental Health Services, Newtownpark Avenue, Blackrock, Co. Dublin, Ireland.

Background: Gaming is a growing area and there are conflicting reports on its harms and benefits. There is also increasing interest in the use of gaming clinically.

Aims: This research aims to enhance our understanding of video and smartphone game use, and perceptions, among outpatients attending an Irish general adult mental health service. Read More

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http://dx.doi.org/10.1007/s11845-019-02016-5DOI Listing

The effect of geodemographic factors on the attendance rates at a regional diabetic retinopathy treatment centre.

Ir J Med Sci 2019 Apr 18. Epub 2019 Apr 18.

Ophthalmology Department, Cork University Hospital, Cork, Ireland.

Aim: To determine whether geodemographic factors, specifically age, gender or commuting distance, affect the attendance rates of patients referred to a Diabetic Retinopathy Treatment (DRT) Centre from the Irish National Diabetic Retinal Screening (DRS) Programme.

Methods: A retrospective analysis of the first 1200 patients who were referred for ophthalmic assessment between November 2013 and June 2015 to Cork University Hospital's (CUH) DRT clinic from the DRS was completed.

Results: A total of 972 (81%) patients attended all their scheduled DRT appointments. Read More

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http://dx.doi.org/10.1007/s11845-019-02009-4DOI Listing
April 2019
1 Read

Genome-wide association study of endo-parasite phenotypes using imputed whole-genome sequence data in dairy and beef cattle.

Genet Sel Evol 2019 Apr 18;51(1):15. Epub 2019 Apr 18.

Animal and Grassland Research and Innovation Centre, Teagasc, Moorepark, Fermoy, Co. Cork, Ireland.

Background: Quantitative genetic studies suggest the existence of variation at the genome level that affects the ability of cattle to resist to parasitic diseases. The objective of the current study was to identify regions of the bovine genome that are associated with resistance to endo-parasites.

Methods: Individual cattle records were available for Fasciola hepatica-damaged liver from 18 abattoirs. Read More

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http://dx.doi.org/10.1186/s12711-019-0457-7DOI Listing

Lonely SARTs: loneliness and sustained attention in the Irish longitudinal study of aging.

Neuropsychol Dev Cogn B Aging Neuropsychol Cogn 2019 Apr 18:1-10. Epub 2019 Apr 18.

c School of Nursing, School of Medicine, and School of Medical Gerontology , Trinity College , Dublin 2 , Ireland.

Based on biologically plausible mechanisms and previous research, it is possible to hypothesize a reciprocal association between sustained attention and loneliness. We investigated this association using a cross-lagged modeling approach. Using data from 6,239 participants aged over 50 in TILDA, a nationally representative study of aging, we used structural equation models to investigate potential cross-lagged associations between sustained attention and loneliness, measured at baseline and again after four years. Read More

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https://www.tandfonline.com/doi/full/10.1080/13825585.2019.1
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http://dx.doi.org/10.1080/13825585.2019.1602705DOI Listing
April 2019
1 Read

Dasatinib Treatment Increases Sensitivity to c-Met Inhibition in Triple-Negative Breast Cancer Cells.

Cancers (Basel) 2019 Apr 17;11(4). Epub 2019 Apr 17.

Molecular Therapeutics for Cancer Ireland, National Institute for Cellular Biotechnology, Dublin City University, Dublin D09 NR58, Ireland.

In pre-clinical studies, triple-negative breast cancer (TNBC) cells have demonstrated sensitivity to the multi-targeted kinase inhibitor dasatinib; however, clinical trials with single-agent dasatinib showed limited efficacy in unselected populations of breast cancer, including TNBC. To study potential mechanisms of resistance to dasatinib in TNBC, we established a cell line model of acquired dasatinib resistance (231-DasB). Following an approximately three-month exposure to incrementally increasing concentrations of dasatinib (200 nM to 500 nM) dasatinib, 231-DasB cells were resistant to the agent with a dasatinib IC value greater than 5 μM compared to 0. Read More

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http://dx.doi.org/10.3390/cancers11040548DOI Listing

Elizabeth Fee (1946-2018).

Am J Public Health 2019 Apr 18:e1-e4. Epub 2019 Apr 18.

Anne-Emanuelle Birn is professor of critical development studies and of social and behavioral health sciences at the Dalla Lana School of Public Health at the University of Toronto, Toronto, Ontario. Theodore M. Brown is professor emeritus of history and public health sciences at the University of Rochester, Rochester, NY.

Elizabeth Fee was a remarkable and influential public health historian, whose personal and professional trajectories led her to speak truth to and about power in public health, past and present. Born in Northern Ireland in 1946 to Irish-Methodist missionary parents, Liz's childhood brought her into contact with peoples and struggles across the globe. At just five weeks of age, she was whisked away by her parents to civil war-era China, where she lost hearing in one ear from an untreated bout with scarlet fever. Read More

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https://ajph.aphapublications.org/doi/10.2105/AJPH.2019.3050
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http://dx.doi.org/10.2105/AJPH.2019.305065DOI Listing
April 2019
2 Reads

Reply to Letter to the Editor Regarding "The Importance of Diagnosing Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features (NIFTP) Based on the Defined Criteria".

Ann Surg Oncol 2019 Apr 16. Epub 2019 Apr 16.

Department of Otolaryngology - Head and Neck Surgery/Surgical Oncology, Princess Margaret Cancer Centre, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1245/s10434-019-07358-zDOI Listing

Quantitative examination of the bone health status of older adults with intellectual and developmental disability in Ireland: a cross-sectional nationwide study.

BMJ Open 2019 Apr 15;9(4):e026939. Epub 2019 Apr 15.

Dean of the Faculty of Health Sciences, Trinity College Dublin, The University of Dublin, Dublin, Ireland.

Objectives: (1) To investigate the prevalence of osteopenia and osteoporosis among adults with intellectual disabilities (IDs) and (2) to examine alternative optimal bone screening techniques.

Design: Observational cross-sectional study.

Setting: Wave 2 (2013-2106) of the Intellectual Disability Supplement to the Irish Longitudinal Study on Ageing. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-026939DOI Listing

Megalithic tombs in western and northern Neolithic Europe were linked to a kindred society.

Proc Natl Acad Sci U S A 2019 Apr 15. Epub 2019 Apr 15.

Human Evolution, Department of Organismal Biology, Uppsala University, SE-752 36 Uppsala, Sweden;

Paleogenomic and archaeological studies show that Neolithic lifeways spread from the Fertile Crescent into Europe around 9000 BCE, reaching northwestern Europe by 4000 BCE. Starting around 4500 BCE, a new phenomenon of constructing megalithic monuments, particularly for funerary practices, emerged along the Atlantic façade. While it has been suggested that the emergence of megaliths was associated with the territories of farming communities, the origin and social structure of the groups that erected them has remained largely unknown. Read More

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http://dx.doi.org/10.1073/pnas.1818037116DOI Listing

Metagenomic 16S rRNA gene sequencing survey of Borrelia species in Irish samples of Ixodes ricinus ticks.

PLoS One 2019 15;14(4):e0209881. Epub 2019 Apr 15.

Milford Molecular Diagnostics, Connecticut, United States of America.

The spirochetal bacterium Borrelia miyamotoi is a human pathogen and has been identified in many countries throughout the world. This study reports for the first time the presence of Borrelia miyamotoi in Ireland, and confirms prior work with the detection of B. garinii and B. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0209881PLOS

PERioperative Fluid Management in Elective ColecTomy (PERFECT)-a national prospective cohort study.

Ir J Med Sci 2019 Apr 13. Epub 2019 Apr 13.

Irish Surgical Research Collaborative, Royal College of Surgeons in Ireland, 123, St. Stephen's Green, Dublin 2, Ireland.

Background: There is contradictory evidence regarding the merits of restricted versus liberal perioperative intravenous (IV) fluid administration in bowel surgery. This study sought to audit perioperative fluid management in elective colectomy in Ireland and to analyse the impact of such on operative outcomes.

Methods: A national surgical trainee collaborative audit of perioperative fluid management was performed. Read More

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http://dx.doi.org/10.1007/s11845-019-02003-wDOI Listing

How herd best linear unbiased estimates affect the progress achievable from gains in additive and nonadditive genetic merit.

J Dairy Sci 2019 Apr 10. Epub 2019 Apr 10.

Teagasc, Animal and Grassland Research and Innovation Center, Moorepark, Fermoy, Co. Cork, Ireland P61 C996. Electronic address:

Sustainable dairy cow performance relies on coevolution in the development of breeding and management strategies. Tailoring breeding programs to herd performance metrics facilitates improved responses to breeding decisions. Although herd-level raw metrics on performance are useful, implicitly included within such statistics is the mean herd genetic merit. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00220302193034
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http://dx.doi.org/10.3168/jds.2018-16119DOI Listing
April 2019
2 Reads

The maternal health behaviours of non-Irish nationals during pregnancy and the effect of time living in Ireland.

Public Health 2019 Apr 10;170:95-102. Epub 2019 Apr 10.

School of Biological Sciences, Technological University for Dublin, Dublin 2, Ireland.

Objectives: Maternal health behaviours (MHBs) can influence pregnancy outcomes. Despite efforts internationally to encourage positive MHBs, women often fail to comply with pregnancy guidelines. International studies show differences in MHBs between nationalities and an effect of time spent in the host country. Read More

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http://dx.doi.org/10.1016/j.puhe.2019.02.023DOI Listing

No indication for CALR mutation analysis in Irish patients presenting with deep vein thrombosis or pulmonary embolism.

Ir J Med Sci 2019 Apr 11. Epub 2019 Apr 11.

Cancer Molecular Diagnostics, Central Pathology Laboratory, St. James's Hospital, Dublin, Ireland.

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http://dx.doi.org/10.1007/s11845-019-02018-3DOI Listing
April 2019
1 Read

Adherence to European Polypectomy Guidelines: Retrospective Experience from a Tertiary Irish Hospital.

Gastrointest Tumors 2019 Feb 22;5(3-4):82-89. Epub 2018 Nov 22.

Department of Gastroenterology AMNCH, Dublin, Ireland.

Background And Study Aim: The European guidelines for colorectal cancer screening state that snare resection should remove any polyps ≥5 mm. This study aimed to investigate if these new guidelines are adhered to in clinical practice.

Patients And Methods: This study consists of patients who underwent colonoscopies in Tallaght Hospital, Dublin (AMNCH), between 2012 and 2015. Read More

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https://www.karger.com/Article/FullText/494351
Publisher Site
http://dx.doi.org/10.1159/000494351DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422123PMC
February 2019
1 Read

Activation of a TLR9 mediated innate immune response in preeclampsia.

Sci Rep 2019 Apr 11;9(1):5920. Epub 2019 Apr 11.

Irish Centre for Fetal and Neonatal Translational Research (INFANT), Cork University Maternity Hospital, Cork, Ireland.

Preeclampsia is a multisystemic disorder leading to the development of a placental ischemic microenvironment with a resultant increase in oxidative stress. There is evidence that mitochondrial dysfunction and the innate immune system both play a role in the pathophysiology of this disease. Mitochondrial DAMPs such as mtDNA bind specific pattern recognition receptors such as Toll-like receptor 9 (TLR9) on the endosomal surface of immune cells, in particular neutrophils, subsequently activating them and triggering an innate response. Read More

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http://dx.doi.org/10.1038/s41598-019-42551-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459858PMC
April 2019
1 Read

To HTA or Not to HTA: Identifying the Factors Influencing the Rapid Review Outcome in Ireland.

Value Health 2019 Apr 6;22(4):385-390. Epub 2019 Mar 6.

Salutem Insights Ltd., Dublin, Ireland.

Objectives: Reimbursement systems are evolving and endeavor to balance access and affordability. One such evolution in Ireland is the compulsory rapid review (RR) process, the outcome from which is a recommendation for a health technology assessment (HTA) or no HTA. For drugs that avoid an HTA, evaluation times are shorter, lengthy price negotiations are avoided, and access is faster. Read More

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http://dx.doi.org/10.1016/j.jval.2018.10.011DOI Listing

Questionnaire survey on helminth control practices in horse farms in Ireland.

Parasitology 2019 Apr 12:1-10. Epub 2019 Apr 12.

School of Veterinary Medicine, University College Dublin,Dublin,Ireland.

Knowledge regarding helminth control strategies and nematode infection of horses in Ireland is limited and only one study has been published recently. This present study was designed to investigate the current helminth control strategies followed by horse owners in Ireland. A questionnaire was formulated to collect data on general grazing, pasture management and deworming strategies including the use of fecal egg counts. Read More

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http://dx.doi.org/10.1017/S0031182019000271DOI Listing

FKBPL and its peptide derivatives inhibit endocrine therapy resistant cancer stem cells and breast cancer metastasis by downregulating DLL4 and Notch4.

BMC Cancer 2019 Apr 11;19(1):351. Epub 2019 Apr 11.

School of Pharmacy, Queen's University Belfast, Belfast, UK.

Background: Optimising breast cancer treatment remains a challenge. Resistance to therapy is a major problem in both ER- and ER+ breast cancer. Tumour recurrence after chemotherapy and/or targeted therapy leads to more aggressive tumours with enhanced metastatic ability. Read More

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http://dx.doi.org/10.1186/s12885-019-5500-0DOI Listing

What Psychosocial Factors Determine the Physical Activity Patterns of University Students?

J Phys Act Health 2019 Apr 11:1-8. Epub 2019 Apr 11.

Background: Although levels of physical activity (PA) have been researched, no information on how university students organize their PA across different life domains is available. The purpose of this study is to explore if and how students organize their PA across transport and recreational domains, and to identify the psychosocial factors related to these patterns.

Methods: Students from 31 Irish universities completed a supervised online survey measuring participant characteristics, psychosocial factors, and PA. Read More

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https://journals.humankinetics.com/doi/10.1123/jpah.2018-020
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http://dx.doi.org/10.1123/jpah.2018-0205DOI Listing
April 2019
3 Reads

Fibrin Sealant Derived from Human Plasma as a Scaffold for Bone Grafts Associated with Photobiomodulation Therapy.

Int J Mol Sci 2019 Apr 10;20(7). Epub 2019 Apr 10.

Department of Biological Sciences (Anatomy), Bauru School of Dentistry, University of São Paulo (USP), Bauru 17012-901, Brazil.

Fibrin sealants derived from human blood can be used in tissue engineering to assist in the repair of bone defects. The objective of this study was to evaluate the support system formed by a xenograft fibrin sealant associated with photobiomodulation therapy of critical defects in rat calvaria. Thirty-six rats were divided into four groups: BC ( = 8), defect filled with blood clot; FSB ( = 10), filled with fibrin sealant and xenograft; BC ( = 8), blood clot and photobiomodulation; FSB ( = 10), fibrin sealant, xenograft, and photobiomodulation. Read More

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https://www.mdpi.com/1422-0067/20/7/1761
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http://dx.doi.org/10.3390/ijms20071761DOI Listing
April 2019
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Understanding regium bonds and their competition with hydrogen bonds in Au2:HX complexes.

Chemphyschem 2019 Apr 11. Epub 2019 Apr 11.

Instituto de Química Médica, CSIC, Juan de la Cierva, 3, E-28006 Madrid, Spain, SPAIN.

A theoretical study of the regium and hydrogen bonds (RB and HB, respectively) in Au2:HX complexes have been carried out by means of CCSD(T) calculations. The theoretical study shows as overall outcome that in all cases the complexes exhibiting RB are more stable that those with HB. The binding energies for RB complexes range between -24 and -180 kJ·mol-1 while those HB complexes are between -6 and -19 kJ·mol-1. Read More

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http://dx.doi.org/10.1002/cphc.201900354DOI Listing

Every Minute Counts: Patterns and Times of Physical Activity Participation in Children From Socially Disadvantaged Areas in Ireland.

J Phys Act Health 2019 Apr 10:1-7. Epub 2019 Apr 10.

Background: The purpose of this study was to investigate daily physical activity (PA) patterns of 8- to 9-year-old Irish children from socially disadvantaged areas.

Methods: Children (N = 408) were asked to wear an ActiGraph accelerometer for a minimum of 4 days. Based on mean daily moderate- to vigorous-intensity PA accumulation, participants were grouped into sex-specific quartiles (Q4, most active; Q1, least active). Read More

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http://dx.doi.org/10.1123/jpah.2018-0368DOI Listing

The seroprevalence of untreated chronic hepatitis C virus (HCV) infection and associated risk factors in male Irish prisoners: a cross-sectional study, 2017.

Euro Surveill 2019 Apr;24(14)

Liverpool John Moores University, Liverpool, United Kingdom.

IntroductionData on chronic hepatitis C (HCV) infection prevalence in European prisons are incomplete and impact the public health opportunity that incarceration provides.AimsWe aimed to estimate the seroprevalence of untreated chronic HCV infection and to identify associated risk factors in an Irish male prison.MethodsWe conducted a cross-sectional study involving a researcher-administered questionnaire, review of medical records and HCV serology. Read More

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http://dx.doi.org/10.2807/1560-7917.ES.2019.24.14.1800369DOI Listing
April 2019
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Is It Time To Review The Vaccination Strategy To Protect Adults Against Invasive Pneumococcal Disease?

Ir Med J 2019 Mar 14;112(3):894. Epub 2019 Mar 14.

The Irish Pneumococcal Reference Laboratory, Irish Meningitis and Sepsis Reference Laboratory, Temple Street Children’s University Hospital, Temple Street, Dublin 1, Ireland.

Pneumococcal conjugate vaccines (PCVs) have reduced the predominant serotypes causing invasive pneumococcal disease (IPD). We assessed the impact of the paediatric 7- and 13-valent pneumococcal conjugate vaccines (PCV7 and PCV13) among older adults. We compared serotype-specific incidence rates from 2007/08 to 2016/17, expressed as incidence rate ratios (IRR). Read More

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The Synergistic Effects of Gold Particles and Dexamethasone on the Electrochemical and Biological Performance of PEDOT Neural Interfaces.

Polymers (Basel) 2019 Jan 5;11(1). Epub 2019 Jan 5.

Centre for Research in Medical Devices, National University of Ireland Galway, Newcastle Road, H91 W2TY Galway, Ireland.

Although neural devices have shown efficacy in the treatment of neurodegenerative diseases, their functionality is limited by the inflammatory state and glial scar formation associated with chronic implantation. The aim of this study was to investigate neural electrode performance following functionalization with an anti-inflammatory coating derived from a conducting polymer poly(3,4-ethylenedioxythiophene) (PEDOT) matrix doped with dexamethasone (Dex) and decorated with Au particles. Pristine PEDOT, PEDOT-Dex and their gold-decorated analogues (PEDOT/Au and PEDOT-Dex/Au) were formulated by electrochemical deposition and characterized with respect to electrode electrochemical properties, surface morphology and biocompatibility towards primary neural cells. Read More

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http://www.mdpi.com/2073-4360/11/1/67
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http://dx.doi.org/10.3390/polym11010067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402010PMC
January 2019
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Trauma assessment clinic: Virtually a safe and smarter way of managing trauma care in Ireland.

Injury 2019 Mar 30. Epub 2019 Mar 30.

Department of Trauma and Orthopaedic Surgery, Tullamore Hospital, Arden Road, Tullamore, Co. Offaly, R35 NY51, Ireland.

Introduction: The Trauma Assessment Clinic [TAC], also referred to as Virtual Fracture Clinic, offers a novel care pathway for patients and is being increasingly utilised across the Irish and UK health care systems. The provision of safe, patient centred, efficient and cost-effective treatment via a multidisciplinary team [MDT] approach is the primary focus of TAC. The Trauma and Orthopaedic unit at Tullamore Hospital was the first centre to introduce a TAC in Ireland and this overview outlines the experiences of this pilot. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00201383193016
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http://dx.doi.org/10.1016/j.injury.2019.03.046DOI Listing
March 2019
4 Reads

Evaluation of unenhanced axial T1W and T2W liver MR images acquired from institutions within the Republic of Ireland and the Kingdom of Saudi Arabia.

Radiography (Lond) 2019 May 22;25(2):e45-e51. Epub 2018 Nov 22.

Radiology Department, King Abdulaziz University Hospital, Jeddah, Saudi Arabia.

Introduction: This multi-site study evaluated two breath-hold sequences commonly utilised for liver MRI; non-enhanced T1W-3D-FS-GRE-TRA and T2W-2D-FSE-TRA sequences, using physical measurements of SNR and CNR, and observer perceptions' (Visual Grading Analysis: VGA).

Methods: Liver MR image datasets (n = 168) from nine hospitals in the Kingdom of Saudi Arabia (KSA) and 11 hospitals in the Republic of Ireland were evaluated. Images were categorised into two groups per sequence, defined by slice thickness (T2W-2D-FSE, ≤5 mm vs ≥ 6 mm and T1W-3D-GRE-FS, ≤3 mm vs 4 mm). Read More

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http://dx.doi.org/10.1016/j.radi.2018.10.005DOI Listing
May 2019
1 Read