11,158 results match your criteria Irish Medical News [Journal]


Impact of maternal body mass index and gestational weight gain on pregnancy complications: An individual participant data meta-analysis of European, North American and Australian cohorts.

BJOG 2019 Feb 20. Epub 2019 Feb 20.

The Generation R Study Group, Erasmus MC, University Medical Center, Rotterdam, the Netherlands.

Objective: To assess the separate and combined associations of maternal pre-pregnancy BMI and gestational weight gain with the risks of pregnancy complications and their population impact.

Design: Individual participant data meta-analysis of 39 cohorts.

Setting: Europe, North America and Oceania. Read More

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http://dx.doi.org/10.1111/1471-0528.15661DOI Listing
February 2019

Transient active force generation and stress fibre remodelling in cells under cyclic loading.

Biomech Model Mechanobiol 2019 Feb 19. Epub 2019 Feb 19.

Discipline of Biomedical Engineering, National University of Ireland Galway, Galway, Ireland.

The active cytoskeleton is known to play an important mechanistic role in cellular structure, spreading, and contractility. Contractility is actively generated by stress fibres (SF), which continuously remodel in response to physiological dynamic loading conditions. The influence of actin-myosin cross-bridge cycling on SF remodelling under dynamic loading conditions has not previously been uncovered. Read More

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http://dx.doi.org/10.1007/s10237-019-01121-9DOI Listing
February 2019

Trauma Recovery Is Cultural: Understanding Shared and Different Healing Themes in Irish and American Survivors of Gender-based Violence.

J Interpers Violence 2019 Feb 19:886260519829284. Epub 2019 Feb 19.

1 University of Michigan, Ann Arbor, USA.

Little research has focused on the trauma healing processes of survivors of gender-based violence (GBV) worldwide. Even less research has utilized cross-cultural comparison to understand shared or culturally-distinct healing goals, creating a gap in understanding how to provide adequate, culturally relevant, and trauma-informed care to survivors. The purpose of this study was to cross-culturally compare shared healing influences and themes of the trauma recovery process in samples of Irish and American female survivors of GBV. Read More

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http://dx.doi.org/10.1177/0886260519829284DOI Listing
February 2019

Mycosphaerella fijiensis, Causal Agent of Black Sigatoka of Musa spp. Found in Puerto Rico and Identified by Polymerase Chain Reaction.

Plant Dis 2006 May;90(5):684

University of Florida, IFAS, Tropical Research and Education Center, Homestead.

Black Sigatoka, also known as black leaf streak, is caused by Mycosphaerella fijiensis Morelet (anamorph Pseudocercospora fijiensis (Morelet) Deighton). It is the most significant disease of bananas and plantains (Musa spp.) because most of the economically important cultivars of exported and staple commodities are highly susceptible. Read More

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http://dx.doi.org/10.1094/PD-90-0684ADOI Listing

Downy Mildew of Rudbeckia fulgida cv. Goldsturm by Plasmopara halstedii in Virginia.

Authors:
C X Hong

Plant Dis 2006 Nov;90(11):1461

Hampton Roads Agricultural Research and Extension Center, Virginia Tech, Virginia Beach, VA 23455.

A severe foliage disease was observed on black-eyed Susan (Rudbeckia fulgida cv. Goldsturm) at a commercial nursery in Virginia Beach, VA in early June of 2005 and 2006. In both years, disease symptoms began after plants were transferred from 1-liter (1quart) to 4-liter (1-gallon) containers. Read More

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http://dx.doi.org/10.1094/PD-90-1461BDOI Listing
November 2006

Three New Races of the Spinach Downy Mildew Pathogen Identified by a Modified Set of Spinach Differentials.

Plant Dis 2007 Nov;91(11):1392-1396

Department of Horticulture, University of Arkansas, Fayetteville.

Spinach downy mildew, caused by Peronospora farinosa f. sp. spinaciae, is the most economically important disease of spinach worldwide. Read More

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http://dx.doi.org/10.1094/PDIS-91-11-1392DOI Listing
November 2007

First Report of Race 8 of Downy Mildew, Caused by Peronospora farinosa f. sp. spinaciae, of Spinach in the United States.

Plant Dis 2007 Sep;91(9):1205

University of California Cooperative Extension, Salinas 93901.

Downy mildew, caused by Peronospora farinosa f. sp. spinaciae, is the most economically important disease of spinach (Spinacia oleracea) in the United States and the European Union. Read More

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http://dx.doi.org/10.1094/PDIS-91-9-1205BDOI Listing
September 2007

First Report of Phytophthora palmivora, Causal Agent of Black Pod, on Cacao in Puerto Rico.

Plant Dis 2007 Aug;91(8):1051

Department of Plant Pathology, Pennsylvania State University, University Park.

Black pod or Phytophthora pod rot is the most economically important and widespread disease of cacao, Theobroma cacao L. Total losses due to Phytophthora exceed $400 million worldwide (1), and several species are known to attack cacao with P. palmivora (E. Read More

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http://dx.doi.org/10.1094/PDIS-91-8-1051BDOI Listing

Why our doctors are leaving Irish emergency medicine training.

Ir J Med Sci 2019 Feb 18. Epub 2019 Feb 18.

Royal College of Physicians of Ireland, Dublin, Ireland.

Background: In recent years, attrition from Emergency Medicine (EM) training in Ireland has increased. Australian data illustrates that increasing numbers of Irish-trained doctors are embarking on EM training in Australia. This has implications for EM in Ireland, particularly for Emergency Departments already under strain. Read More

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http://dx.doi.org/10.1007/s11845-019-01976-yDOI Listing
February 2019

Planning, Implementing, and Running a Multicentre Preterm Birth Study with Biobank Resources in Brazil: The Preterm SAMBA Study.

Biomed Res Int 2019 16;2019:5476350. Epub 2019 Jan 16.

Department of Obstetrics and Gynecology, University of Campinas (UNICAMP), School of Medical Sciences, Campinas, SP, Brazil.

Background: Our aim was to describe the steps in planning, implementing, and running a multicentre cohort study of maternal and perinatal health using a high-quality biobank comprised of maternal serum, plasma, and hair samples collected from five sites in Brazil. The Preterm SAMBA study, conducted by the Brazilian Network for Studies on Reproductive and Perinatal Health, was an innovative approach used to identify women at higher risk for preterm birth. It is also of great importance in the study of other maternal and perinatal complications in the context of Brazil, which is a middle-income country. Read More

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https://www.hindawi.com/journals/bmri/2019/5476350/
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http://dx.doi.org/10.1155/2019/5476350DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354138PMC
January 2019
1 Read

Parents and clinicians: partners in perinatal bereavement research -experiences from the International Stillbirth Alliance Conference 2017.

Res Involv Engagem 2019 1;5. Epub 2019 Feb 1.

1Pregnancy Loss Research Group, Irish Centre for Fetal and Neonatal Translational Research (INFANT), University College Cork, Cork, Ireland.

In recent years, there has been a global call to reduce the numbers of preventable stillbirths and increase public awareness about the incidence and impact of pregnancy loss. The lived experiences of bereaved parents have much to contribute to developing the research agenda and clinical care in pregnancy loss. The multidisciplinary Pregnancy Loss Research Group (PLRG) based at the INFANT Centre at University College Cork and Cork University Maternity Hospital, has an established practice of active engagement and participation of patient members. Read More

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http://dx.doi.org/10.1186/s40900-018-0137-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357380PMC
February 2019

Use of continuous glucose monitoring for sport in type 1 diabetes.

BMJ Open Sport Exerc Med 2018 17;4(1):e000432. Epub 2018 Dec 17.

School of Medicine, National University of Ireland, Galway, Ireland.

Background: The benefits of exercise for patients with type 1 diabetes (T1D) are difficult to balance with associated glycaemic excursions. The aim of this cohort study was to show that continuous glucose monitoring (CGM) could reduce glycaemic excursions in patients with T1D already using insulin pumps, exercising at moderate to high intensity.

Methods: Questionnaires were used to identify patients with T1D using insulin pumps and naive to CGM use, who reported regular exercise. Read More

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http://dx.doi.org/10.1136/bmjsem-2018-000432DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350713PMC
December 2018

Fin whale (Balaenoptera physalus) mitogenomics: A cautionary tale of defining sub-species from mitochondrial sequence monophyly.

Mol Phylogenet Evol 2019 Feb 13. Epub 2019 Feb 13.

Marine Evolution and Conservation, Groningen Institute of Evolutionary Life Sciences, University of Groningen, Nijenborgh 7, 9747 AG, Groningen, The Netherlands; Center for Coastal Studies, 5 Holway Avenue, Provincetown, MA 02657, United States of America. Electronic address:

The advent of massive parallel sequencing technologies has resulted in an increase of studies based upon complete mitochondrial genome DNA sequences that revisit the taxonomic status within and among species. Spatially distinct monophyly in such mitogenomic genealogies, i.e. Read More

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http://dx.doi.org/10.1016/j.ympev.2019.02.003DOI Listing
February 2019
1 Read

Acute multiple sclerosis lesion pathology does not predict subsequent clinical course-a biopsy study.

Ir J Med Sci 2019 Feb 15. Epub 2019 Feb 15.

Department of Neuropathology, Beaumont Hospital, Beaumont Road, Dublin, Ireland.

Background: Knowledge of the clinical outcome in tumefactive demyelination remains limited.

Aims: This study aims to characterise the natural history of biopsy-proven, pathogen-free, cerebral demyelination in an adult Irish population.

Methods: We identified all patients with biopsy-proven demyelination in a single neuropathology centre between 1999 and 2017. Read More

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http://dx.doi.org/10.1007/s11845-019-01983-zDOI Listing
February 2019
2 Reads

Increased galactose expression and enhanced clearance in patients with Low von Willebrand factor.

Blood 2019 Feb 15. Epub 2019 Feb 15.

Haemostasis Research Group, Department of Molecular and Cellular Therapeutics, Irish Centre for Vascular Biology, Royal College of Surgeons in Ireland, Dublin, Ireland.

Glycan determinants on von Willebrand factor (VWF) play critical roles in regulating its susceptibility to proteolysis and clearance. Abnormal glycosylation has been shown to cause VWD in a number of different mouse models. However, due to the significant technical challenges associated with accurate assessment of VWF glycan composition, the importance of carbohydrates in human VWD pathogenesis remains largely unexplored. Read More

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http://dx.doi.org/10.1182/blood-2018-09-874636DOI Listing
February 2019

Increased Leucocyte-Platelet Complex Formation in Recently Symptomatic versus Asymptomatic Carotid Stenosis Patients and in Micro-emboli Negative Subgroups.

Thromb Haemost 2019 Feb 15. Epub 2019 Feb 15.

Department of Neurology, Adelaide and Meath Hospital, Dublin, incorporating the National Children's Hospital (AMNCH)/Tallaght University Hospital, Dublin, Ireland.

Introduction:  Cerebral micro-embolic signals (MES) predict risk of stroke in carotid stenosis patients. However, MES-negative 'recently symptomatic patients' also have a higher stroke risk than 'asymptomatic patients'. Differences in platelet activation status may contribute to this disparity in risk. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0039-1678666
Publisher Site
http://dx.doi.org/10.1055/s-0039-1678666DOI Listing
February 2019
2 Reads

Psychometric Evaluation of a Measure of Factors Influencing Hand Hygiene Behaviour to Inform Intervention.

J Hosp Infect 2019 Feb 12. Epub 2019 Feb 12.

Irish Centre for Applied Patient Safety and Simulation, School of Medicine, National University of Ireland Galway, Ireland; Discipline of General Practice, School of Medicine, National University of Ireland Galway, Ireland. Electronic address:

Background: Although the hand hygiene (HH) procedure is simple, the related behaviour is complex and is not readily understood, explained, or changed. There is a need for practical tools to provide data that can guide healthcare managers and practitioners not only on the 'what' (the standards that must be met), but also the 'how' (guidance on how to achieve the standards).

Aim: To develop a valid questionnaire to evaluate attitudes to the factors that influence engagement in HH behaviour that can be readily completed, administered, and analysed by healthcare professionals to identify appropriate intervention strategies. Read More

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http://dx.doi.org/10.1016/j.jhin.2019.02.003DOI Listing
February 2019

Cognitive performance and functional outcomes of carriers of pathogenic copy number variants: analysis of the UK Biobank.

Br J Psychiatry 2019 Feb 15:1-8. Epub 2019 Feb 15.

Professor, Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics,Cardiff University,UK.

Background: Rare copy number variants (CNVs) are associated with risk of neurodevelopmental disorders characterised by varying degrees of cognitive impairment, including schizophrenia, autism spectrum disorder and intellectual disability. However, the effects of many individual CNVs in carriers without neurodevelopmental disorders are not yet fully understood, and little is known about the effects of reciprocal copy number changes of known pathogenic loci.AimsWe aimed to analyse the effect of CNV carrier status on cognitive performance and measures of occupational and social outcomes in unaffected individuals from the UK Biobank. Read More

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http://dx.doi.org/10.1192/bjp.2018.301DOI Listing
February 2019
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The helminth parasite community of European badgers (Meles meles) in Ireland.

J Helminthol 2019 Feb 15:1-4. Epub 2019 Feb 15.

Department of Zoology, School of Natural Sciences, Trinity College Dublin,Ireland.

The European badger (Meles meles) is Ireland's largest terrestrial carnivore. Since first being identified as a wildlife reservoir of bovine tuberculosis in 1974 there has been an increased research focus into the behaviour of these ecologically important mammals in the Republic of Ireland (ROI). However, to date there has never been an assessment of the helminth parasite community of Irish badgers. Read More

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http://dx.doi.org/10.1017/S0022149X19000051DOI Listing
February 2019
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The European Alpha-1 Research Collaboration (EARCO): a new ERS Clinical Research Collaboration to promote research in alpha-1 antitrypsin deficiency.

Eur Respir J 2019 Feb 14;53(2). Epub 2019 Feb 14.

Dept of Medicine, Pulmonary and Critical Care Medicine, University Medical Centre Giessen and Marburg, Philipps-University, Member of the German Centre for Lung Research (DZL), Marburg, Germany.

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http://dx.doi.org/10.1183/13993003.00138-2019DOI Listing
February 2019
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Over prescribing of antibiotics for acute respiratory tract infections; a qualitative study to explore Irish general practitioners' perspectives.

BMC Fam Pract 2019 Feb 14;20(1):27. Epub 2019 Feb 14.

Graduate Entry Medical School, University of Limerick, Limerick, Ireland.

Background: Anti-microbial resistance (AMR) is a global threat to public health and antibiotics are often unnecessarily prescribed for acute respiratory tract infections (ARTIs) in general practice. We aimed to investigate why general practitioners (GPs) continue to prescribe antibiotics for ARTIs despite increasing knowledge of their poor efficacy and worsening antimicrobial resistance.

Methods: We used an explorative qualitative study design. Read More

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http://dx.doi.org/10.1186/s12875-019-0917-8DOI Listing
February 2019

A randomised controlled trial of the Group Stepping Stones Triple P training programme for parents of children with developmental disabilities.

Clin Child Psychol Psychiatry 2019 Feb 15:1359104519827622. Epub 2019 Feb 15.

2 Health Service Executive, Ireland.

The central aim of this study was to examine the effectiveness of Group Stepping Stones Triple P (GSSTP) in an Irish context for families of children with both developmental disabilities and internalising and externalising behavioural problems. Parents of 84 children (mean age = 5.73; SD = 2. Read More

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http://dx.doi.org/10.1177/1359104519827622DOI Listing
February 2019

Mercury concentrations in marine species from the Aleutian Islands: Spatial and biological determinants.

Sci Total Environ 2019 Jan 31;664:761-770. Epub 2019 Jan 31.

Department of Veterinary Medicine, University of Alaska Fairbanks, 901 Koyukuk Drive, Fairbanks, AK 99775-7750, USA.

Several species found in the Bering Sea show significant spatial variation in total mercury concentrations ([THg]) longitudinally along the Aleutian Island chain. We assessed [THg] in other members of the Bering Sea food web to better understand the factors shaping regional differences. [THg] and stable carbon and nitrogen isotope ratios (δN and δC values) were measured in muscle tissue from 1052 fishes and cephalopods from parts of the Bering Sea and North Pacific Ocean adjacent to the Aleutian Islands. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.01.387DOI Listing
January 2019
1 Read

Variance components for bovine tuberculosis infection and multi-breed genome-wide association analysis using imputed whole genome sequence data.

PLoS One 2019 14;14(2):e0212067. Epub 2019 Feb 14.

Teagasc, Animal and Grassland Research and Innovation Centre, Moorepark, Fermoy, Co. Cork, Ireland.

Bovine tuberculosis (bTB) is an infectious disease of cattle generally caused by Mycobacterium bovis, a bacterium that can elicit disease humans. Since the 1950s, the objective of the national bTB eradication program in Republic of Ireland was the biological extinction of bTB; that purpose has yet to be achieved. Objectives of the present study were to develop the statistical methodology and variance components to undertake routine genetic evaluations for resistance to bTB; also of interest was the detection of regions of the bovine genome putatively associated with bTB infection in dairy and beef breeds. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212067PLOS
February 2019
1 Read

Challenges and supports towards the integration of ePortfolios in education. Lessons to be learned from Ireland.

Heliyon 2018 Nov 30;4(11):e00899. Epub 2018 Nov 30.

EQI, The Centre for Evaluation, Quality and Inspection, DCU Institute of Education, Ireland.

This paper reports on research derived from a one-year study on the integration of ePortfolios in education using Ireland as a case example. Through a series of interviews with school principals, teachers and members of the support service of the Department of Education and Skills in Ireland, this research explores the opportunities and challenges relating to the use of ePortfolios in Irish post-primary education. Evidence suggests that, whilst supports for the integration of ePortfolios are beginning to emerge, there are many unresolved issues. Read More

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http://dx.doi.org/10.1016/j.heliyon.2018.e00899DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6275690PMC
November 2018

Extracranial and Intracranial Vasculopathy With "Moyamoya Phenomenon" in Association With Alagille Syndrome.

Front Neurol 2018 29;9:1194. Epub 2019 Jan 29.

Department of Neurology, The Adelaide and Meath Hospital, Dublin, Incorporating The National Children's Hospital (AMNCH)/Tallaght University Hospital, Dublin, Ireland.

Alagille syndrome (AGS) is an autosomal-dominant, multisystem disorder caused by mutations in the JAG1 gene. A 34-year-old man was referred to our service 10 years ago with focal seizures with impaired awareness and transient slurred speech. He had a 5-year history of intermittent left monocular low-flow retinopathy. Read More

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http://dx.doi.org/10.3389/fneur.2018.01194DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362309PMC
January 2019
1 Read

Risk Perceptions Toward Drinking Water Quality Among Private Well Owners in Ireland: The Illusion of Control.

Risk Anal 2019 Feb 13. Epub 2019 Feb 13.

School of Earth Sciences, University College Dublin, Dublin, Ireland.

In rural areas where no public or group water schemes exist, groundwater is often the only source of drinking water and is extracted by drilling private wells. Typically, private well owners are responsible for the quality and testing of their own drinking water. Previous studies indicate that well owners tend to underestimate the risks of their well water being contaminated, yet little is known about why this is the case. Read More

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http://dx.doi.org/10.1111/risa.13283DOI Listing
February 2019

'We are the change' - An innovative community-based response to address self-stigma: A pilot study focusing on people living with HIV in Zimbabwe.

PLoS One 2019 13;14(2):e0210152. Epub 2019 Feb 13.

RCSI Institute of Leadership, Royal College of Surgeons in Ireland, Dublin, Ireland.

Introduction: Self-stigma-negative self-judgements resulting in shame, worthlessness and self-blame-may play a crucial role in emotional reactions and cause emotional distress among many people living with HIV and other chronic illnesses. Furthermore, self-stigma negatively impacts on self-agency, quality of life, adherence to treatment, and access to services. High levels of self-stigma have been reported across many countries, however few programmes or interventions exist to specifically tackle this phenomenon. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0210152PLOS
February 2019

Moderate-intensity aerobic and resistance exercise is safe and favorably influences body composition in patients with quiescent Inflammatory Bowel Disease: a randomized controlled cross-over trial.

BMC Gastroenterol 2019 Feb 12;19(1):29. Epub 2019 Feb 12.

Department of Medicine, National University of Ireland, University College Cork, Cork University Hospital, Wilton, T12 DC4A, Cork, Ireland.

Background: Overweight and metabolic problems now add to the burden of illness in patients with Inflammatory Bowel Disease. We aimed to determine if a program of aerobic and resistance exercise could safely achieve body composition changes in patients with Inflammatory Bowel Disease.

Methods: A randomized, cross-over trial of eight weeks combined aerobic and resistance training on body composition assessed by Dual Energy X-ray Absorptiometry was performed. Read More

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http://dx.doi.org/10.1186/s12876-019-0952-xDOI Listing
February 2019

Thromboprophylaxis for varicose vein procedures - A national survey.

Phlebology 2019 Feb 12:268355519828931. Epub 2019 Feb 12.

Department of Vascular Surgery, Royal Victoria Hospital, Belfast, UK.

Background: Venous thromboembolism is rare following varicose vein ablation procedures, but uncertainty about its incidence combined with a lack of evidence-based clinical guidelines regarding thromboprophylaxis has led to debate about best practice. We conducted a national survey to investigate current practice among Irish vascular surgeons.

Methods: An anonymous online questionnaire was emailed to all members of the Irish Association of Vascular Surgeons and the Northern Ireland Vascular Society. Read More

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http://dx.doi.org/10.1177/0268355519828931DOI Listing
February 2019
1 Read

Does locally delivered small group continuing medical education (CME) meet the learning needs of rural general practitioners?

Educ Prim Care 2019 Feb 12:1-7. Epub 2019 Feb 12.

a Health Sciences Centre, UCD , University College Dublin School of Medicine , West Waterford , Ireland.

The World Health Organisation policy of improving retention of rural health care practitioners recommended that continuing medical education (CME) programmes addressing their needs should be accessible and delivered where they live and work. This cross-sectional study involved a self-administered anonymous questionnaire completed by GPs attending CME small groups (CME-SGL) in Ireland. All GPs attending CME-SGL in a one-month period were invited to complete the questionnaire which examined demographic details, distance to travel to educational meetings/nearest regional hospital, barriers to accessing continuing education, whether CME-SGL met their educational needs, morale and professional isolation. Read More

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http://dx.doi.org/10.1080/14739879.2019.1573109DOI Listing
February 2019

Cryptic diets of forage fish: jellyfish consumption observed in the Celtic Sea and western English Channel.

J Fish Biol 2019 Feb 12. Epub 2019 Feb 12.

School of Biological Sciences, University of East Anglia, Norfolk, UK.

To establish if fishes' consumption of jellyfish changes through the year, we conducted a molecular gut-content assessment on opportunistically sampled species from the Celtic Sea in October and compared these with samples previously collected in February and March from the Irish Sea. Mackerel Scomber scombrus were found to feed on hydrozoan jellyfish relatively frequently in autumn, with rare consumption also detected in sardine Sardina pilchardus and sprat Sprattus sprattus. By October, moon jellyfish Aurelia aurita appeared to have escaped predation, potentially through somatic growth and the development of stinging tentacles. Read More

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http://dx.doi.org/10.1111/jfb.13926DOI Listing
February 2019

The relationship between IGF-I and -II concentrations and body composition at birth and over the first 2 months.

Pediatr Res 2019 Feb 11. Epub 2019 Feb 11.

The Irish Centre for Fetal and Neonatal Translational Research, Cork, Ireland.

Background: Insulin-like growth factor (IGF)-I and -II play an important role in prenatal growth. During the first 2 months from birth, body fat doubles, and rapid weight gain during this time increases future risk of cardiometabolic disease. The aim of this study was to determine whether IGF measurements at birth associate with body composition and the trajectory of its changes in the first 2 months. Read More

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http://dx.doi.org/10.1038/s41390-019-0331-xDOI Listing
February 2019

Education from other journals #12.

Br J Sports Med 2019 Feb 11. Epub 2019 Feb 11.

Glen Sather Sports Medicine Clinic, Edmonton, Alberta, Canada.

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http://dx.doi.org/10.1136/bjsports-2018-100283DOI Listing
February 2019
1 Read

"Do as we say, not as we do?" the lifestyle behaviours of hospital doctors working in Ireland: a national cross-sectional study.

BMC Public Health 2019 Feb 11;19(1):179. Epub 2019 Feb 11.

Research Department, Royal College of Physicians of Ireland, Dublin, Ireland.

Background: This study was conducted to assess the lifestyle behaviours of a national sample of hospital doctors working in Ireland. We also sought to compare the prevalence of these behaviours in doctors to the general Irish population.

Methods: This was a national cross-sectional study of a randomised sample of hospital doctors working in Irish publicly funded hospitals and residential institutions. Read More

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http://dx.doi.org/10.1186/s12889-019-6451-8DOI Listing
February 2019

HER2-Targeted Tyrosine Kinase Inhibitors Cause Therapy-Induced-Senescence in Breast Cancer Cells.

Cancers (Basel) 2019 Feb 8;11(2). Epub 2019 Feb 8.

Molecular Therapeutics for Cancer Ireland, National Institute for Cellular Biotechnology, Dublin City University, Glasnevin, 9 Dublin, Ireland.

Prolonged treatment of HER2 positive breast cancer cells with tyrosine kinase inhibitors (TKIs) leads to the emergence of acquired resistance. However, the effects of continuous TKI exposure on cell fate, and the steps leading to the acquisition of a resistant phenotype are poorly understood. To explore this, we exposed five HER2 positive cells lines to HER2 targeted therapies for periods of up to 4 weeks and examined senescence associated β-galactosidase (SA-β-gal) activity together with additional markers of senescence. Read More

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http://dx.doi.org/10.3390/cancers11020197DOI Listing
February 2019
1 Read

Maternal body mass index, gestational weight gain, and the risk of overweight and obesity across childhood: An individual participant data meta-analysis.

PLoS Med 2019 Feb 11;16(2):e1002744. Epub 2019 Feb 11.

The Generation R Study Group, Erasmus University Medical Center, Rotterdam, the Netherlands.

Background: Maternal obesity and excessive gestational weight gain may have persistent effects on offspring fat development. However, it remains unclear whether these effects differ by severity of obesity, and whether these effects are restricted to the extremes of maternal body mass index (BMI) and gestational weight gain. We aimed to assess the separate and combined associations of maternal BMI and gestational weight gain with the risk of overweight/obesity throughout childhood, and their population impact. Read More

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http://dx.plos.org/10.1371/journal.pmed.1002744
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http://dx.doi.org/10.1371/journal.pmed.1002744DOI Listing
February 2019
4 Reads

EuGMS Task and Finish group on Fall-Risk-Increasing Drugs (FRIDs): Position on Knowledge Dissemination, Management, and Future Research.

Drugs Aging 2019 Feb 11. Epub 2019 Feb 11.

Department of Internal Medicine, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands.

Falls are a major public health concern in the older population, and certain medication classes are a significant risk factor for falls. However, knowledge is lacking among both physicians and older people, including caregivers, concerning the role of medication as a risk factor. In the present statement, the European Geriatric Medicine Society (EuGMS) Task and Finish group on fall-risk-increasing drugs (FRIDs), in collaboration with the EuGMS Special Interest group on Pharmacology and the European Union of Medical Specialists (UEMS) Geriatric Medicine Section, outlines its position regarding knowledge dissemination on medication-related falls in older people across Europe. Read More

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http://dx.doi.org/10.1007/s40266-018-0622-7DOI Listing
February 2019
2 Reads

The Road to Improving Access to Surgical Specialist Consultations: Ontario's Experience with Wait 1 Wait Time Data.

Healthc Q 2018 Oct;21(3):42-50

Was born and educated in Alberta but moved to Ontario for his postgraduate training in orthopedic surgery at the University of Toronto. He has occupied a number of positions at St. Michael's Hospital, including surgeon-in-chief and medical director of the Trauma Program, and completed 10 years as professor and chairman, Division of Orthopaedic Surgery at University of Toronto. In 2006, Dr. Waddell became the provincial lead for orthopaedic surgery for Access to Care and is responsible for the Orthopaedic Surgery Wait Times portfolio.

In 2009, the Ontario Ministry of Health and Long-Term Care engaged Cancer Care Ontario to expand the Wait Time Information System to capture surgical consultation data (Wait 1). Over the years, an increasing number of patient and provider reports have shown that Wait 1 wait times account for a significant portion of the total wait time for surgery. With data published online by the ministry in late summer 2017, patients were given access to consultation wait time information for over 200 types of procedures at 92 surgical facilities in Ontario. Read More

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http://dx.doi.org/10.12927/hcq.2018.25701DOI Listing
October 2018

Prescriber Variation in Relation to Prescribing Trends within the Preferred Drugs Initiative in Ireland (2012-2015): An Interrupted Time Series Study Using Latent Curve Models.

Med Decis Making 2019 Feb 9:272989X18818165. Epub 2019 Feb 9.

Health Research Board (HRB) Centre for Primary Care Research, Department of General Practice, Royal College of Surgeons in Ireland Medical School, Dublin 2, Ireland.

Objectives: To examine the impact of the Preferred Drugs Initiative (PDI), an Irish health policy aimed at reducing prescribing variation.

Design: Interrupted time series spanning 2012 to 2015.

Setting: Health Service Executive pharmacy claims data for General Medical Services (GMS) patients, approximately 40% of the Irish population. Read More

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http://dx.doi.org/10.1177/0272989X18818165DOI Listing
February 2019

Trends in road transport collision deaths in the Irish paediatric population: a retrospective review of mortality data, 1991-2015.

BMJ Paediatr Open 2019 23;3(1):e000361. Epub 2019 Jan 23.

RCSI Department of Paediatrics, Temple Street Children's University Hospital, Dublin, Ireland.

Objective: To establish the incidence of road transport collision (RTC) fatalities in the Irish paediatric population, examining trends in fatality rates over a period of 25 years, during which several national road safety interventions were implemented.

Study Design: Retrospective review of death registration details of children 0-19 years in Ireland between January 1991 and December 2015. Trends in mortality rates were investigated using average annual per cent change and Poisson regression analysis. Read More

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http://dx.doi.org/10.1136/bmjpo-2018-000361DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347854PMC
January 2019

Spatiotemporal analysis of prolonged and recurrent bovine tuberculosis breakdowns in Northern Irish cattle herds reveals a new infection hotspot.

Spat Spatiotemporal Epidemiol 2019 Feb 14;28:33-42. Epub 2018 Nov 14.

Veterinary Sciences Division, Agri-food and Biosciences Institute (AFBI), 12 Stoney Road, Stormont, Belfast BT4 3SD, UK; School of Biological Sciences, Queen's University Belfast, Belfast, UK.

Despite a state-led eradication programme, bovine tuberculosis (bTB) remains endemic in Northern Ireland (NI). Of particular concern are "chronic" prolonged and recurrent bTB breakdowns, which represent significant financial and administrative burdens. However, little is known regarding the spatiotemporal distribution of chronic breakdowns in NI. Read More

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http://dx.doi.org/10.1016/j.sste.2018.11.002DOI Listing
February 2019

GDPR: an impediment to research?

Ir J Med Sci 2019 Feb 8. Epub 2019 Feb 8.

Beaumont Hospital Ethics (Medical Research) Committee, Beaumont Hospital, Dublin, Ireland.

Background: The recent introduction of the General Data Protection Regulation and Health Research Regulations has been an area of significant concern for those engaged in clinical research. These European regulations, following subsequent interpretation by Ireland's Department of Health, now place Ireland in a unique position which differs substantially from other European countries and may prove a significant impediment to Irish clinical research, depriving Irish patients of timely access to potentially life-saving treatments and making Ireland less attractive to pharmaceutical companies engaged in this area. At the very least, the regulations, as applied in Ireland, will place a significant extra burden of work on Ireland's clinical researchers and at their worst will force individuals and institutions out of the clinical research field, which will result in significant loss to the Irish knowledge economy and lead to the detriment of patient care. Read More

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http://link.springer.com/10.1007/s11845-019-01980-2
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http://dx.doi.org/10.1007/s11845-019-01980-2DOI Listing
February 2019
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Comparing trap designs and methods for assessing density of synanthropic flies in Odisha, India.

Parasit Vectors 2019 Feb 7;12(1):75. Epub 2019 Feb 7.

Department of Disease Control, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK.

Background: There are many different traps available for studying fly populations. The aim of this study was to find the most suitable trap to collect synanthropic fly populations to assess the impact of increased latrine coverage in the state of Odisha, India.

Methods: Different baits were assessed for use in sticky pot traps (60% sucrose solution, 60 g dry sucrose, half a tomato and an non-baited control), followed by different colours of trap (blue versus yellow) and finally different types of trap (baited sticky pot trap versus sticky card traps). Read More

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http://dx.doi.org/10.1186/s13071-019-3324-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367737PMC
February 2019

Radiologist's views on anatomical knowledge amongst junior doctors and the teaching of anatomy in medical curricula.

Ann Anat 2019 Feb 4. Epub 2019 Feb 4.

Department of Anatomy, Trinity Biomedical Sciences Institute, School of Medicine, Trinity College Dublin, Dublin, Ireland. Electronic address:

Reduced teaching resources, increasing student numbers and congested medical curricula have reportedly led to reports of inadequate anatomical knowledge among newly qualified doctors, placing scrutiny on pre-clinical education. We wished to gauge the opinions of practicing radiologists on undergraduate anatomy education. Members of the Irish Faculty of Radiologists were invited to complete a questionnaire based on undergraduate anatomical education. Read More

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http://dx.doi.org/10.1016/j.aanat.2019.01.011DOI Listing
February 2019

Parental perspective on neonatal outcomes.

Authors:
Mandy Daly

BMJ Paediatr Open 2019 13;3(1):e000404. Epub 2019 Jan 13.

Director of Advocacy and Policy Making, Irish Neonatal Health Alliance, Bray, Ireland.

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http://dx.doi.org/10.1136/bmjpo-2018-000404DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340574PMC
January 2019

Variation in Nonmelanoma Skin Cancer Incidence by Treatment Modality Among Patients Receiving Multiple Kidney Transplants.

JAMA Dermatol 2019 Feb 6. Epub 2019 Feb 6.

Department of Nephrology and Kidney Transplantation, Beaumont Hospital Dublin, Ireland.

Importance: Existing data suggest that nonmelanoma skin cancer (NMSC) is more common in renal transplant recipients than in maintenance dialysis patients. However, whether the risk of NMSC varies as the treatment modality for end-stage kidney disease (ESKD) changes between dialysis and transplantation is not well described.

Objective: To determine whether the incidence of NMSC is attenuated during periods of graft loss with a return to dialysis in those who receive multiple kidney transplants. Read More

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http://dx.doi.org/10.1001/jamadermatol.2018.4660DOI Listing
February 2019
1 Read

Do Differences in Spatiotemporal Gait Parameters Predict the Risk of Developing Depression in Later Life?

J Am Geriatr Soc 2019 Feb 5. Epub 2019 Feb 5.

The Irish Longitudinal Study on Ageing Trinity College Dublin, Dublin, Ireland.

Background/objectives: There is growing interest in the association between gait disturbance and depression in later life. The aim of this study is to clarify the longitudinal relationship between specific gait parameters and incident depression within a population-representative sample of older people.

Design: Longitudinal analysis of spatiotemporal gait parameters at baseline (wave 1) and incident depression at 2 and 4 years (waves 2/3). Read More

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http://dx.doi.org/10.1111/jgs.15783DOI Listing
February 2019
2 Reads

TREatment of ATopic eczema (TREAT) Registry Taskforce: consensus on how and when to measure the core dataset for atopic eczema treatment research registries.

Br J Dermatol 2019 Feb 4. Epub 2019 Feb 4.

Unit for Population-Based Dermatology Research, St John's Institute of Dermatology, Guy's& St Thomas' NHS Foundation Trust and King's College London, London, UK.

Background: Comparative, real-life and long-term evidence on the effectiveness and safety of photo- and systemic therapy in moderate-to-severe atopic eczema (AE) is limited. Such data must come from well-designed prospective patient registries. Standardisation of data collection is needed for direct comparisons and data pooling. Read More

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http://dx.doi.org/10.1111/bjd.17715DOI Listing
February 2019