865 results match your criteria Iranian journal of kidney diseases[Journal]


Sofosbuvir and Daclatsvir in Treatment of Hepatitis C Virus-related Membranoproliferative Glomerulonephritis With Cryoglobulinemia in a Patient With Hepatitis C Genotype 4.

Iran J Kidney Dis 2018 Nov;12(6):382-384

Urology and Nephrology Center, Mansoura University, Egypt.

Direct antivirals showed dramatic response in hepatitis C virus (HCV) eradication, but their effect on extrahepatic manifestations is still unclear. A 49-year-old woman was referred to us suffering from lower limb edema and frothy urine. Renal biopsy was done and she was diagnosed with HCV-related membranoproliferative glomerulonephritis with cryoglobulinemia. Read More

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November 2018
1 Read

C3 Glomerulonephritis With Multiple Mutations in Complement Factor H.

Iran J Kidney Dis 2018 Nov;12(6):376-381

Chronic Kidney Disease Research Center, Department of Nephrology, Labbafinejad Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Complement C3 glomerulopathy refers to a disease process in which abnormal control of complement activation or degradation results in predominant C3 fragment deposition within the glomerulus and causes glomerular damage. Abnormal control of the complement alternative pathway is a well-established risk factor for the occurrence of C3 glomerulonephritis. It is the first reported case in Iran with multiple mutations in complement factor H, with one of these mutations we have expected in hemolytic uremic syndrome rather than C3 glomerulopathy Genetic analysis showed that the molecular abnormalities of factor H led to complement factor H malfunction that were polymorphous and not restricted to the C-terminal domains of the protein. Read More

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November 2018
1 Read
0.979 Impact Factor

Downregulation of Profibrotic Gene Expression by Angiotensin Receptor Blockers.

Iran J Kidney Dis 2018 Nov;12(6):369-375

Department of Internal Medicine, Aliebne Abitaleb Hospital, Zahedan University of Medical Sciences, Zahedan, Iran.

Introduction: Chronic allograft nephropathy is characterized by interstitial fibrosis and tubular atrophy. The main players in the process of fibrosis are transforming growth factor-β (TGF-β) and miR-21 expression with a bidirectional interplay. This study aimed to evaluate the effects of angiotensin receptor type 1 antagonist, losartan, on peripheral blood and tissue expression of TGF-β and miR-21 and histologic findings in allograft biopsy in kidney transplant recipients. Read More

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November 2018
1 Read

Prevalence of Pulmonary Hypertension in End-stage Renal Disease Patients Undergoing Hemodialysis and Peritoneal Dialysis at a Referral Center in Mashhad, Iran, From 2015 to 2016.

Iran J Kidney Dis 2018 Nov;12(6):364-368

Departmentof Cardiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Introduction: Pulmonary artery hypertension is a serious comorbidityof dialysis in patients with end-stage renal disease. The prevalence of dialysis-induced pulmonary artery hypertension is still a subject of debate. The aim of this study was to determine the prevalence of pulmonary artery hypertension in patients undergoing hemodialysis and peritoneal dialysis. Read More

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November 2018
5 Reads

Treatment Effect of Ergocalciferol on Bone Metabolism Indexes and Parathyroid Hormone in Hemodialysis Patients.

Iran J Kidney Dis 2018 Nov;12(6):359-363

Department of Internal Medicine, Ardabil University of Medical Sciences, Ardabil, Iran.

Introduction: Vitamin D deficiency is a common problem in end-stage renal disease patients under hemodialysis. Both active and nutritional vitamin D supplementation have been recommended for its treatment. In this study we aimed to evaluate the effects of treatment with ergocalciferol on bone metabolism indexes in hemodialysis patients. Read More

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November 2018
2 Reads

Molecular Genetic Analysis of PKHD1 Mutations in Pedigrees With Autosomal Recessive Polycystic Kidney Disease.

Iran J Kidney Dis 2018 Nov;12(6):350-358

Department of Medical Genetics, Tarbiat Modares University, Teheran, Iran.

Introduction: A wide variety of mutations are spread throughout the PKHD1 gene, which encodes a 4074-bp amino acid protein, namely fibrocystin/polyductin, and is responsible for all features of autosomal recessive polycystic kidney disease (ARPKD). Autosomal recessive polycystic kidney disease is a hereditary early-onset form of polycystic kidney disease characterized by fusiform dilation of collecting ducts and congenital hepatic fibrosis. The highest level of PKDH1 expression is in the kidneys of fetus and adults, suggesting the functionally importance of the gene in the mature kidney in addition to its role in kidney development. Read More

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November 2018
1 Read

TRPC6 Mutational Analysis in Iranian Children With Focal Segmental Glomerulosclerosis.

Iran J Kidney Dis 2018 Nov;12(6):341-349

Isfahan Kidney Diseases Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.

Introduction: Focal segmental glomerulosclerosis (FSGS) ranks among nephrotic syndromes. Research shows that FSGS is brought about by several genes including transient receptor potential cation channel subfamily c member 6 (TRPC6). This study aimed to investigate TRPC6 gene in Iranian FSGS children. Read More

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November 2018
1 Read
0.979 Impact Factor

Brachial Artery Flow-mediated Dilatation and Carotid Intima-Media Thickness in Children With Idiopathic Nephrotic Syndrome.

Iran J Kidney Dis 2018 Nov;12(6):331-340

Department of Pediatrics, Faculty of Medicine, Zagazig University, Zagazig, Egypt.

Introduction: Disturbances of lipid metabolism has been reported in nephrotic syndrome (NS) and may predispose to atherosclerosis. This study aimed to investigate the correlation between cardiovascular risk factors and carotid intima-media thickness (CIMT) and brachial artery flow-mediated dilatation in patients with idiopathic NS.

Materials And Methods: This case-control study included 31 patients with NS and 31 healthy individuals as the control group. Read More

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November 2018
1 Read

Cyclosporine in Pediatric Nephrology.

Iran J Kidney Dis 2018 Nov;12(6):319-330

Department of Pediatrics, Division Pediatric Nephrology, Medical Faculty of Dokuz Eylul University, Izmir, Turkey.

Cyclosporine began to be used as one of the immunosuppressive agents in transplantation in the beginning of the 1980s, and in the treatment of nephrotic syndrome in the pediatric nephrology. Therapeutic area of cyclosporine is narrow and its side effects limit its usage. Preference for cyclosporine and tacrolimus as a calcineurin inhibitor is left for the choice of the department. Read More

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November 2018
2 Reads

Successful Treatment of Posttransplant Recurrent Complement C3 Glomerulopathy with Eculizumab.

Iran J Kidney Dis 2018 Oct;12(5):315-318

Department of Nephrology, Diskapi Yildirim Beyazit Education and Research Hospital, Ankara, Turkey.

Two-thirds of complement C3 glomerulopathy (C3G) recur after transplantation and commonly cause graft loss. There is not a standard treatment protocol for these cases. We present a kidney transplant patient with recurrent C3G who was successfully treated with eculizumab. Read More

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October 2018
19 Reads

Cutaneous Infection With Mycobacterium haemophilum in an Immunocompromised Patient.

Iran J Kidney Dis 2018 Oct;12(5):312-314

Infectious Diseases and Tropical Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Mycobacterium haemophilum is a fastidious nontuberculosis Mycobacterium that must be considered in the differential diagnosis of infections in immunocompromised patients. Mycobacterium haemophilum typically is a pathogen of the cutaneous or subcutaneous tissue and also presents as septic arthritis, osteomyelitis, pulmonary disease, and lymphadenitis. We report a 32-year-old man with past medical history of kidney transplantation, endocarditis, gastrointestinal bleeding, and hypertension, complaining of multiple painful nodular lesions since 3 months earlier. Read More

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October 2018
14 Reads

Association of Forkhead Box P3 Gene Polymorphisms With Allograft Rejection Episodes in Kidney Transplant Patients: a Study From Kashmir, North India.

Iran J Kidney Dis 2018 Oct;12(5):305-311

Department of Neprology, Sher i Kashmir Institute of Medical Sciences, Soura Srinagar J and K, India.

Introduction: The forkhead box P3 (FOXP3) gene is important for regulation and development of T cells, which are mediators of kidney allograft rejection. The FOXP3 gene polymorphism may be associated with the rejection of kidney transplants. This study was designed to determine the association of FOXP3 polymorphism with kidney transplant rejection. Read More

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October 2018
18 Reads
0.980 Impact Factor

Serum Matrix Metalloproteinase-9, Tissue Inhibitor of Metalloproteinase-1 and Matrix Metalloproteinase-9/ Neutrophil Gelatinase-associated Lipocalin Complex Levels in Patients With Early-stage Diabetic Nephropathy.

Iran J Kidney Dis 2018 Oct;12(5):299-304

Department of Biochemistry, Sanliurfa Mehmet Akif Inan Training and Research Hospital, Sanliurfa, Turkey.

Introduction: This study was aimed to investigate the efficacy of matrix metalloproteinase-9 (MMP-9), tissue inhibitor of metalloproteinase-1 (TIMP-1), and the neutrophil gelatinase-associated lipocalin (NGAL)-bound form of MMP-9 (MMP-9/NGAL complex) markers in the determination of early nephropathy in patients with type 2 diabetes mellitus.

Materials And Methods: Twenty-five type 2 diabetic patients with normoalbuminuria, 27 type 2 diabetic patients with microalbuminuria, and 23 healthy controls were recruited. Serum levels of MMP-9, TIMP-1, and MMP9/NGAL complex were measured in all participants. Read More

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October 2018
10 Reads

Myocardial Function in Egyptian Pediatric Patients With Acute Nephritic Syndrome.

Iran J Kidney Dis 2018 Oct;12(5):293-298

Department of Pediatrics, Faculty of Medicine, Tanta University, Tanta, Egypt.

Introduction: Acute nephritic syndrome (ANS) is the most common cause of hypertensive heart failure in pediatric population. There are few publications on myocardial evaluation using electrocardiographic and echocardiographic data in pediatric patients with ANS. This study aimed to evaluate myocardial function by electrocardiography and 2-dimensional echocardiography in Egyptian pediatric patients with ANS. Read More

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October 2018
1 Read

Efficacy and Safety of Mycophenolate Mofetil Versus Intravenous Pulse Cyclophosphamide as Induction Therapy in Proliferative Lupus Nephritis.

Iran J Kidney Dis 2018 Oct;12(5):288-292

Connective Tissue Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Introduction: Lupus nephritis is a common and severe manifestation of systemic lupus erythematosus that can lead to end-stage renal disease and death. The aim of this study was to compare the efficacy and safety of mycophenolate mofetil (MMF) and cyclophosphamide as induction therapy and subsequently as maintenance therapy for lupus nephritis.

Materials And Methods: In this retrospective case-control study, 67 patients with proliferative lupus nephritis who were treated with MMF (n = 45) and pulse of intravenous cyclophosphamide (n = 22) were included. Read More

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October 2018
11 Reads

Effect of Sevelamer on Serum Levels of Klotho and Soluble Tumor Necrosis Factor-like Weak Inducer of Apoptosis in Rats With Adenine-induced Chronic Kidney Disease.

Iran J Kidney Dis 2018 Oct;12(5):281-287

Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Introduction: Nontraditional risk factors for cardiovascular disease (CVD), including mineral disorder, high fibroblast growth factor 23 (FGF23), low klotho, and low soluble TWEAK could predict the incipient risk of CVD in chronic kidney disease (CKD). The present study evaluates the effect of sevelamer on soluble tumor necrosis factor-like weak inducer of apoptosis (TWEAK), and klotho levels in adenine-induced CKD rats.

Methods And Materials: Normal control rats without sevelamer were compared with 3 groups of adenine-induced CKD rats, including CKD rats without sevelamer, CKD rats treated with 3% sevelamer, and rats receiving adenine and 3% sevelamer concurrently. Read More

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October 2018
6 Reads

Association of Vitamin D Deficiency with Increased Pulse Wave Velocity and Augmentation Index in Children With Chronic Kidney Disease.

Iran J Kidney Dis 2018 Oct;12(5):275-280

Ege University Faculty of Medicine, Department of Pediatric Nephrology, ?zmir, Turkey.

Introduction: It is known that in children with chronic kidney disease (CKD), cardiovascular damage starts in the form of arterial stiffness. There are risk factors other than the traditional ones such as arterial stiffness hypertension, obesity, hypercholesterolemia, and insulin resistance. Vitamin D deficiency is rather common in CKD, and it was introduced as a risk factor for atherosclerosis; however, its relationship with arterial stiffness is not known completely. Read More

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October 2018
13 Reads

Prevalence and Associated Factors of Chronic Kidney Disease Among Patients Infected With Human Immunodeficiency Virus in Cameroon.

Iran J Kidney Dis 2018 Oct;12(5):268-274

Department of Internal Medicine, Douala General Hospital; Faculty of Medicine and Pharmaceutical Sciences, University of Douala; Douala, Cameroon.

Introduction: Chronic kidney disease (CKD) is frequent amongst human immunodeficiency virus (HIV)-positive patients, and screening is not routinely performed in Sub-Saharan Africa due to resource constraints. We aimed to determine the prevalence of CKD and associated factors in HIV-infected patients in Cameroon.

Materials And Methods: A cross-sectional study in Northern Cameroon included HIV-positive patients who attended the HIV clinic. Read More

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October 2018
15 Reads

Acute Kidney Injury Risk Recognition in Resource-Sufficient Versus Resource-Limited Regions.

Iran J Kidney Dis 2018 Oct;12(5):261-267

Division of Nephrology and Hypertension; Division of Pulmonary and Critical Care Medicine; Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA.

Acute kidney injury is a very common complication of acute illnesses with dire consequences. There are significant differences in incidence, etiology, severity, and clinical impact of acute kidney injury between resource-sufficient and resource-limited regions. Awareness of such differences would potentially allow clinicians and policymakers to devise and provide region-specific interventions to decrease the incidence of acute kidney injury and mitigate its complications. Read More

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October 2018
6 Reads

Potential Adverse Effects of Creatine Supplement on the Kidney in Athletes and Bodybuilders.

Iran J Kidney Dis 2018 10;12(5):253-260

Department of Clinical Pharmacy, Faculty of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.

Introduction: Nowadays, creatine is one of the most common oral supplements used by professional athletes for boosting their strength and muscle mass. In this review, we collect available experimental and clinical data about renal safety of both short-term and long-term use of creatine.

Materials And Methods: Scientific literature was critically searched by keywords "creatine," "renal insufficiency," and "renal dysfunction" and their synonyms in medical databases (Scopus, MEDLINE, EMBase, and ISI Web of Knowledge). Read More

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October 2018
12 Reads

Myocardial Infarction-triggered Thrombotic Microangiopathy.

Iran J Kidney Dis 2018 07;12(4):250-251

Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

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July 2018
0.980 Impact Factor

A Case of Acrorenal Syndrome.

Iran J Kidney Dis 2018 07;12(4):247-249

Cellular and Molecular Biology Research Center; Cancer Research Center; Health Research Institute; Clinical Research Development Center, Shahid Beheshti Hospital; Department of Internal Medicine, School of Medicine; Babol University of Medical Sciences, B.

Urinary tract anomalies are common and comprise about 20% to 30% of total congenital anomalies. This spectrum consists of many different anomalies of the urinary tract that may be syndromic or nonsyndromic with different etiologies. In this case report, a patient with single kidney and urinary tract signs is introduced that was diagnosed accidentally. Read More

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July 2018
1 Read

Immunoglobulin G4-related Kidney Disease Associated With Autoimmune Hemolytic Anemia.

Iran J Kidney Dis 2018 07;12(4):243-246

Renal Division, Department of Medicine, West China Hospital of Sichuan University, Chengdu, China.

Awareness of the uncommon associated clinical manifestations of immunoglobulin G4 (IgG4)-related kidney disease is essential for the early diagnosis and effective treatment of patients. To the best of our knowledge, there have been few reports of patients with IgG4-related kidney disease associated with autoimmune hemolytic anemia. We here report a rare case of IgG4-related kidney disease associated with autoimmune hemolytic anemia. Read More

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July 2018
5 Reads

Molecular Study of Nephronophthisis in 7 Unrelated Pakistani Families.

Iran J Kidney Dis 2018 07;12(4):240-242

Medical Genetics Research Laboratory, Department of Biotechnology, Quaid-I-Azam University, Islamabad, Pakistan.

Nephronophthisis is an autosomal recessive cystic kidney disease characterized by tubular interstitial infiltration, periglomerular fibrosis, and cysts, and is the most frequent genetic cause of end-stage renal disease in children. Nephronophthisis is pleiotropic as almost all the causative genes are involved in primary cilium and centrosome function which are found in almost all human cells. Genetic heterogeneity in nephronophthisis makes the molecular and genetic diagnosis somewhat difficult. Read More

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July 2018
3 Reads

Correlation of Caveolin-1 With Vascular Intimal Thickness for Different Locations of Catheter Tips in a Dog Model.

Iran J Kidney Dis 2018 07;12(4):232-239

Department of Kidney Disease and Blood Purification Centre, Institute of Urology and Key Laboratory of Tianjin, 2nd Hospital of Tianjin Medical University, Tianjin, China.

Introduction: Many studies have reported increased intimal thickness around the catheter tip after catheterization. Caveolin-1 is a protein in the endothelial cell that acts as a shear sensor causing vascular remodeling. This study aimed to elucidate the suitability of different catheter locations and determine the role of caveolin-1 in canine models. Read More

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July 2018
2 Reads

Vitamin D Receptor Gene Polymorphisms and Environment Influencing the Impact on Survival in Hemodialysis Patients.

Iran J Kidney Dis 2018 07;12(4):223-231

School of Life Sciences, Pontifícia Universidade Católica do Paraná, Curitiba, Brazil.

Introduction: The vitamin D-receptor axis is involved in multiple physiological functions and altered states such as hypertension, mineral metabolism disorders, and inflammation. These disturbances are major risk factors for progression to end-stage kidney disease and cardiovascular disease. In addition, changes in internal systemic environment could be influencing the impact of survival in patients with kidney disease. Read More

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July 2018
7 Reads

Effects of Flaxseed Oil on Serum Bone Turnover Markers in Hemodialysis Patients: a Randomized Controlled Trial.

Iran J Kidney Dis 2018 07;12(4):215-222

Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Introduction: Chronic kidney disease-mineral and bone disorder is a common complication in hemodialysis patients. The present study was designed to investigate the effects of flaxseed oil, a rich source of plant omega-3 fatty acid alpha-linolenic acid, on serum markers of bone formation and resorption in hemodialysis patients.

Materials And Methods: In this randomized controlled trial, 34 hemodialysis patients were randomly assigned to either the flaxseed oil or the control group. Read More

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July 2018
1 Read

Serum Apelin Peptide Level in Hemodialysis Patients With Pulmonary Arterial Hypertension.

Iran J Kidney Dis 2018 07;12(4):209-214

Department of Internal Medicine, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran.

Introduction: Pulmonary arterial hypertension (PAH) is a destructive disease that is characterized by vasoconstriction, alterations and abnormal angiogenesis in pulmonary vessels, and right ventricular dysfunction. There is no certain treatment known for this condition. Patients with PAH have a lower level of apelin in their blood and less apelin is secreted in their endothelial cells, but this condition is not investigated in hemodialysis patients. Read More

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July 2018
1 Read

Alkaline Diet: a Novel Nutritional Strategy in Chronic Kidney Disease?

Iran J Kidney Dis 2018 07;12(4):204-208

Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Science, Tehran, Iran.

Chronic kidney disease is defined as a glomerular filtration rate lower than 60 mL/min/1.73 m2, which is regarded as a public health priority and part of the growing burden of noncommunicable diseases. Reduced kidney function is concomitant with high levels of inflammatory factors, abnormal lipid profile, and anemia, as well as bone abnormalities, calcium deposition outside the bones, endothelial dysfunction, and cardiomyopathy. Read More

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July 2018
6 Reads

End-stage Renal Disease in the Middle East: a Systematic Review and Meta-analysis.

Iran J Kidney Dis 2018 07;12(4):195-203

Shiraz Nephro-Urology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Introduction: End-stage renal disease (ESRD) results in unpleasant consequences for patients, their families, and also society. Annually, each country expends a huge amount for ESRD treatment. In addition, its prevalence is dramatically growing, though it can be prevented. Read More

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July 2018
1 Read

Re: Association Between Klotho Gene Polymorphism and Markers of Bone Metabolism in Patients Receiving Maintenance Hemodialysis in Iran.

Iran J Kidney Dis 2018 05;12(3):193

KMT Primary Care Center, Bangkok, Thailand.

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May 2018
6 Reads

Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor in the Adrenal Gland of a Child.

Iran J Kidney Dis 2018 05;12(3):190-192

Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Ewing sarcoma/peripheral primitive neuroectodermal tumor (ES/PNET) typically occurs in long or flat bones, soft tissues, or less often, solid organs. Ewing sarcoma/peripheral primitive neuroectodermal tumor arising from the adrenal gland is extremely rare, especially in children, and only limited cases are reported previously. Herein, we review a case of a 22-month-old girl who presented to our department with abdominal pain, bulging of the left flank, and a nonfunctioning adrenal lesion which was found to be an adrenal ES/PNET. Read More

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May 2018
5 Reads

Blood Pressure Measurement and Left Ventricular Mass Index in Hemodialysis Patients: Comparison of Several Methods.

Iran J Kidney Dis 2018 05;12(3):185-189

Division of Nephrology, Department of Medicine, Hasheminejad Kidney Center, Iran University of Medical Sciences; National research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences; Tehran, Iran.

Introduction: Systemic arterial hypertension is prevalent in end-stage renal disease and is closely associated with left ventricular hypertrophy (LVH). Blood pressure (BP) behavior is unique in this population, and it is not clear which BP measurement should be used for treatment guidance. We aimed to evaluate the association of several methods of BP measurement with left ventricular mass index (LVMI) as hypertensive end-organ damage. Read More

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May 2018
4 Reads

Characteristics of Patients Initializing Peritoneal Dialysis Treatment From 2007 to 2014: Analysis From Henan Peritoneal Dialysis Registry data.

Iran J Kidney Dis 2018 05;12(3):178-184

Department of Nephrology, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, China; Arthritis Research UK Primary Care Centre, Research Institute for Primary Care and Health Sciences, Keele University, Keele, UK.

Introduction: This study aimed to assess the number and profiles of patients initializing peritoneal dialysis form the Henan Peritoneal Dialysis Registry, a provincial database in central China.

Materials And Methods: All patients aged 18 years and greater, initializing peritoneal dialysis within the province during 2007 to 2014 were included. Demographic characteristics were collected and clinical parameters included the type of renal diagnosis (primary glomerular, secondary glomerular, and others) and recorded major comorbidities in the neural, cardiovascular, respiratory, gastrointestinal, and endocrine systems. Read More

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May 2018
1 Read

Association of Matrix Metalloproteinase-2 and Matrix Metalloproteinase-9 With Endothelial Dysfunction, Cardiovascular Disease Risk Factors and thrombotic events in Children With End-stage Renal Disease.

Iran J Kidney Dis 2018 05;12(3):169-177

Isfahan Kidney Diseases Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.

Introduction: Cardiovascular disease (CVD) is the main cause of death in children with end-stage renal disease (ESRD). Matrix metalloproteinases (MMP-2 and MMP-9) are members of endopeptidases which contribute to CVD. The aim of this study was to evaluate the association of MMP-2 and MMP-9 with markers of endothelial dysfunction, soluble E-selectin and brachial flow-mediated dilatation; several biochemical risk factors of CVD; and thrombotic incidents in children with ESRD. Read More

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May 2018
9 Reads

Correlation Between Circulating Visfatin and Nitric Oxide Metabolites Levels in Patients With Diabetic Nephropathy.

Iran J Kidney Dis 2018 05;12(3):163-168

Drug Applied Research Center; Department of Clinical Biochemistry, Faculty of Medicine, Tabriz University of Medical Sciences; Tabriz, Iran.

Introduction: Diabetic nephropathy is one of the serious complications of diabetes mellitus. Visfatin is an intracellular enzyme with insulin-mimicking effects. It enhances the expression of endothelial nitric oxide (NO) synthase in renal cells. Read More

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May 2018
22 Reads

Effects of High-dose Vitamin E Supplementation on Markers of Cardiometabolic Risk and Oxidative Stress in Patients with Diabetic Nephropathy: a Randomized Double-blinded Controlled Trial.

Iran J Kidney Dis 2018 05;12(3):156-162

Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran.

Introduction: Patients with diabetic nephropathy (DN) may benefit from vitamin E's antilipid and antioxidant activities. This study aimed to evaluate the effects of high-dose vitamin E supplementation on markers of cardiometabolic risk and oxidative stress in patients with DN.

Materials And Methods: This randomized controlled trial was carried out on 54 patients with DN that were randomly divided into 2 groups to receive vitamin E supplement (800 IU/d) or placebo for 12 weeks. Read More

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May 2018
19 Reads

Angiotensin Converting Enzyme Gene Insertion/Deletion Variant and Familial Mediterranean Fever-related Amyloidosis.

Iran J Kidney Dis 2018 05;12(3):150-155

Department of Medical Genetic, Faculty of Medicine, Hitit University, Corum, Turkey.

Introduction: The most important complication of familial Mediterranean fever (FMF) is secondary amyloidosis, which can lead to kidney failure. Genetic variability in the genes of various components of the renin-angiotensin system may play a role in the pathogenesis of the kidney disorders.  The aim of the present study was to investigate the association between angiotensin converting enzyme (ACE) gene I/D variant and risk of developing FMF-related amyloidosis in Turkish patients. Read More

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May 2018
15 Reads
0.980 Impact Factor

Insulin Receptor Substrate 2 mRNA Expression in Urinary Sediment Cells as a Diagnostic Marker of Nephropathy in Diabetic Patients.

Iran J Kidney Dis 2018 05;12(3):142-149

Department of Medical Genetics, Institute of Medical Biotechnology, National Institute of Genetic Engineering and Biotechnology, Tehran, Iran.

Introduction: The initiation and progression of diabetic nephropathy (DN) is complex. Quantification of mRNA expression in urinary sediment cells (USCs) has emerged as a novel strategy for studying kidney diseases. Insulin requires a family of insulin receptor substrate (IRS) proteins for its physiological effects, and many reports have highlighted the role of insulin and IRS proteins in kidney physiology and disease. Read More

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May 2018
17 Reads

Contrast-induced Nephropathy: Essentials and Concerns.

Iran J Kidney Dis 2018 05;12(3):135-141

Chronic Kidney Disease Research Center, Department of Nephrology, Labbafinejad Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

The administration of radiocontrast media may lead to kidney injury, known as contrast-induced nephropathy, which is reversible in most cases, but its development may be associated with adverse outcomes. This review article provides recommendations for the prevention of contrast nephropathy. Read More

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May 2018
4 Reads

Light Chain Deposition Disease Associated With Multiple Myeloma Developing in Late Pregnancy.

Iran J Kidney Dis 2018 03;12(2):132-134

Department of Internal Medicine, Pusan National University School of Medicine, Yangsan, Busan, Republic of Korea.

Preeclampsia is the most common cause of proteinuria with hypertension during pregnancy. Primary kidney disease and kidney disease secondary to systemic disorders may rarely occur during pregnancy, resulting in proteinuria. A 34-year-old woman was admitted to our hospital with abdominal distention and lower extremity edema. Read More

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March 2018
5 Reads

Classification of Acute Rejection Episodes in Kidney Transplantation: a Proposal Based on Factor Analysis.

Iran J Kidney Dis 2018 03;12(2):123-131

Department of Nephrology and Renal Transplantation, National Institute of Cardiology "Ignacio Chávez", Mexico City, Mexico.

Introduction: Kidney transplantation is considered the ideal treatment for end-stage renal disease. Acute rejection can influence graft survival. The aim of this study was to propose a classification system for acute rejection based on factor analysis. Read More

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March 2018
3 Reads

Effect of Angiotensin II Receptor Type 1 Antibodies on Kidney Allograft Function.

Iran J Kidney Dis 2018 03;12(2):120-122

Iran University of Medical Sciences, Tehran, Iran.

Introduction: Non-human leukocyte antigen antibodies are an independent risk factor for acute rejection in kidney transplant recipients. Among them, angiotensin II receptor type 1 (ART1) antibodies can induce various effects, but their clinical importance in kidney transplant recipients has not been properly explained. This study aimed to evaluate the effect of ART1 antibodies on allograft function and hypertension in stable kidney transplant recipients. Read More

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March 2018
4 Reads

Epidemiologic Association of Nonalcoholic Fatty Liver Disease and Urinary Calculi: a Population-based Cross-sectional Study in Southern China.

Iran J Kidney Dis 2018 03;12(2):112-119

Center for Genomic and Personalized Medicine, Guangxi Medical University; Institute of Urology and Nephrology, First Affiliated Hospital of Guangxi Medical University; Guangxi Key Laboratory for Genomic and Personalized Medicine; Guangxi Collaborative Inn.

Introduction: Nonalcoholic fatty liver disease (NAFLD) has been reported to have effects on kidney diseases; however, a link between NAFLD and urinary calculi remains to be confirmed. This study was conducted on a male population based on our previous Fangchenggang Area Male Health and Examination Survey in Guangxi, China in order to estimate the frequency of urinary calculi and assess the association between NAFLD and urinary calculi while controlling for possible confounders.

Materials And Methods: This was a population-based cross-sectional study conducted in the Fangchenggang region in Guangxi, China. Read More

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March 2018
6 Reads

Urinary CD80 as a Replacement for Renal Biopsy for Diagnosis of Pediatric Minimal Change Disease.

Iran J Kidney Dis 2018 03;12(2):107-111

Departement of Pediatrics, Faculty of Medicine, Beni-Suef University, Egypt.

Introduction: Early diagnosis of minimal change disease (MCD) is challenging in nephrotic children. CD80 is a protein expressed on the surface of podocytes associated with nephrotic syndrome and it is implicated in the induction of proteinuria. This study aimed to investigate the use of urinary CD80 for the diagnosis of MCD. Read More

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March 2018
77 Reads
0.980 Impact Factor

Protection Against Doxorubicin-induced Nephropathy by Plantago major in Rat.

Iran J Kidney Dis 2018 03;12(2):99-106

Neurogenic Inflammation Research Center; Neurocognitive Research Center; Mashhad University of Medical Sciences, Mashhad, Iran.

Introduction: Nephropathy is an important side effect of doxorubicin. The aim of the current study was to investigate the protective effect of Plantago major extract against doxorubicin-induced functional and histological damage in rat's kidney.

Materials And Methods: Sixty Albino rats were randomly divided into 6 groups. Read More

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March 2018
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Clinical Characterization of Serum Docosahexaenoic Acid and Its Relationship With Inflammation Factors in Patients With Diabetic Nephropathy.

Iran J Kidney Dis 2018 03;12(2):91-98

Department of Endocrinology and Metabolism, Huai'an First People's Hospital, Nanjing Medical University, Huaian, Jiangsu Province, China.

Introduction: A variety of molecular pathways, such as generation of advanced glycation end products, inflammation, and oxidative stress, are involved in the development of diabetic nephropathy (DN). Recently, a protective effect of omega-3 polyunsaturated fatty acids on the kidney has been reported. This study aimed to determine serum docosahexaenoic acid (DHA) level and its association with inflammation factors in patients with DN. Read More

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March 2018
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Antioxidative Effects of Tempol on Mitochondrial Dysfunction in Diabetic Nephropathy.

Iran J Kidney Dis 2018 03;12(2):84-90

Urology and Nephrology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.

Introduction: Oxidative stress has a well-known role in diabetic nephropathy, and mitochondria are the major source of reactive oxygen species production. This study aimed to assess the effect of tempol, a superoxide dismutase mimetic agent, on mitochondrial antioxidant enzymes and cell viability in diabetic nephropathy.

Materials And Methods: Adult male Wistar rats were divided into 4 groups of 7 animals. Read More

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March 2018
4 Reads
0.980 Impact Factor

A Systematic Review and Meta-analysis of Using Acupuncture and Acupressure for Uremic Pruritus.

Iran J Kidney Dis 2018 03;12(2):78-83

Clinical Research Unit, Mashhad University of Medical Sciences, Mashhad, Iran.

Introduction: Uremic pruritus is characterized by an uncomfortable and unlimited sensation which leads to scratch, which strongly reduces the quality of life. Pruritus is a common symptom in patients with end-stage renal disease. Various clinical trial studies have examined the effects of acupuncture and acupressure on treatment of uremic pruritus. Read More

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March 2018
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What We Do and Do Not Know About Women and Kidney Diseases: Questions Unanswered and Answers Unquestioned: Reflection on World Kidney Day and International Woman's Day.

Iran J Kidney Dis 2018 03;12(2):65-77

Department of Medicine, Division of Nephrology, University of British Columbia, Vancouver, British Columbia, Canada.

Chronic kidney disease affects approximately 10% of the world's adult population; it is within the top 20 causes of death worldwide, and its impact on patients and their families can be devastating. The World Kidney Day and the International Women's Day coincide in 2018, thus offering an opportunity to reflect on the importance of women's health, and specifically their kidney health, on the community and the next generations, as well as to strive to be more curious about the unique aspects of kidney disease in women so that we may apply those learnings more broadly. Girls and women, who make up approximately 50% of the world's population, are important contributors to society and their families. Read More

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March 2018
9 Reads