885 results match your criteria Iranian journal of kidney diseases[Journal]


Rituximab to Abbreviate Plasma Exchange in Anti-CFH (Complement Factor H) Antibody Mediated Atypical HUS.

Iran J Kidney Dis 2019 Mar;13(2):134-138

Fortis Institute of Renal Transplantation Sciences, Fortis Hospital, Vasant Kunj, India.

While terminal complement blockade with Eculizumab is the first line therapy for atypical HUS (Haemolytic uremic syndrome), lack of its availability and cost limits its use. Plasma exchange becomes a first line modality in the current scenario. However, exposure to large volumes of allogenic plasma and lack of skilled manpower are the limiting factors associated with it. Read More

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March 2019
0.979 Impact Factor

A Rare Case of Acute Kidney Injury: McKittrick Wheelock Syndrome.

Iran J Kidney Dis 2019 Mar;13(2):132-133

University of Health Sciences, Konya Research and Training Hospital, Nephrology Department, Konya, Turkey.

McKittrick-Wheelock syndrome is a rare complication of rectosigmoid villous adenoma leading to secretory diarrhea, prerenal acute kidney injury and severe fluid and electrolyte imbalances. There are about 50 cases reported in literature. We represent a case of 71 year-old patient with persistant chronic diarrhea, prerenal azotemia, severe hypokalemia, and hyponatremia. Read More

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March 2019
2 Reads

Acute Kidney Injury Following Usage of Formaldehyde-Free Hair Straightening Products.

Iran J Kidney Dis 2019 Mar;13(2):129-131

Department of Pediatrics, Faculty of Medicine, Beni-Suef University, Egypt.

Acute kidney injury is manifested by sudden deterioration of kidney functions, with or without reduction of urine output. The spectrum of injury ranges from mild to severe, sometimes requires renal replacement therapy. The initial workup includes a patient history to identify the use of nephrotoxic medications or systemic illnesses that may cause poor renal perfusion or directly impair renal function. Read More

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March 2019
5 Reads
0.979 Impact Factor

Cardiac Biomarkers and Cardiovascular Outcome in Children with Chronic Kidney Disease.

Iran J Kidney Dis 2019 Mar;13(2):120-128

Department of Pediatrics, Faculty of Medicine (for Girls), Al-Azhar University, Cairo, Egypt.

Introduction: Myocardial dysfunction is a leading cause of mortality in chronic kidney disease (CKD) children specially those on regular hemodialysis. Cardiac biomarkers play a key role for early detection of myocardial injury. We aim to clarify the prognostic role of circulating cardiac biomarkers, heart type fatty acid binding protein (H-FABP) and pregnancy associated plasma protein-A (PAPP-A) in CKD children on regular hemodialysis. Read More

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March 2019
1 Read

Effect of Dialysate Glucose Concentration on Hepcidin Clearance in Maintenance Hemodialysis Patients.

Iran J Kidney Dis 2019 Mar;13(2):113-119

Department of Nephrology, Xuzhou Central Hospital, Medical College of Southeast University, Xuzhou, Jiangsu, China.

Introduction: Hepcidin is a key regulator of iron homeostasis, takes part in pathophysiology of anemia and cardiovascular disease in maintenance hemodialysis (MHD) patients. The aim of this study was to compare the effect of glucose-free and glucose-containing dialysate on the clearance of hepcidin-25 during a hemodialysis (HD) session and discuss its potential mechanism in MHD patients.

Methods: In a longitudinal interventional study of 30 stable MHD patients without diabetes, we measured serum hepcidin-25 and plasma catecholamines (adrenaline, noradrenaline, and dopamine) during HD session using glucose-free dialysate and then switched to 5. Read More

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Platelet Activation and Inflammation in Hypertensive Children with Non-dipper and Dipper Status.

Iran J Kidney Dis 2019 Mar;13(2):105-112

Department of Pediatric Nephrology, Faculty of Medicine, Eskisehir Osmangazi University, Turkey.

Introduction: The patients with non-dipper hypertension have an increased risk for target organ damage because of inflammation and platelet activation. In this study, we aimed to investigate the association between ambulatory blood pressure monitoring (ABPM) values and inflammation with platelet indices in children with dipper and non-dipper hypertension.

Materials And Methods: A total of 153 patients who underwent ABPM were included in this retrospective study. Read More

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March 2019
1 Read

Ferric Citrate Attenuates Cardiac Hypertrophy and Fibrosis in a Rat Model of Chronic Kidney Disease.

Iran J Kidney Dis 2019 Mar;13(2):98-104

Division of Nephrology and Hypertension, Department of Medicine, University of California, Irvine, USA.

Introduction: Chronic kidney disease (CKD) promotes hypertrophy and fibrosis in heart, and increases the risk of cardiovascular mortality. Ferric citrate is a dietary phosphate binder used to control hyperphosphatemia in CKD patients. It has been shown to raise iron stores, improve anemia and secondary hyperparathyroidism, and decrease vascular calcification in CKD patients. Read More

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March 2019
1 Read

Key Genes and Signaling Pathways Contribute to the Pathogensis of Diabetic Nephropathy.

Iran J Kidney Dis 2019 Mar;13(2):87-97

Department of Nephrology, China-Japan Union Hospital of Jilin University, No.126 Xiantai Street, Changchun, China.

Introduction: Diabetic nephropathy (DN) is a serious complication of diabetes mellitus involving damage to the capillaries in the glomerulus. This study aimed to explore key genes and signaling pathways participate in the progression of DN.

Methods: Two gene expression profile datasets GSE1009 and GSE30528 downloaded from Gene Expression Omnibus (GEO) were used to analyze the differentially expressed genes (DEGs) between DN samples and controls. Read More

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March 2019
2 Reads

Analyzing Mitochondrial Dysfunction, Oxidative Stress, and Apoptosis: Potential Role of L-carnitine.

Iran J Kidney Dis 2019 Mar;13(2):74-86

Department of Toxicology and Pharmacology, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.

Mitochondrial dysfunction, apoptosis and oxidative stress, are the interrelated events underlining the pathology of  numerous diseases including cardiovascular, neurologic, and metabolic disorders. Due to playing a critical role in glucose and fatty acids' metabolism, L-carnitine probably has the potential to adjust these unfavorable events. The present review has evolved based on existing literature that investigated the mechanisms of L-carnitine and its derivatives based mitochondrial dysfunction, oxidative stress, and apoptosis related modulation. Read More

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Dr Bijan Nikakhtar's Biography.

Authors:
Behrooz Broumand

Iran J Kidney Dis 2019 Mar;13(2):73

Department of Nephrology, Iran University of Medical Sciences, Tehran, Iran.

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Association of Mucopolysaccharidosis Type 4A and Bartter Syndrome.

Iran J Kidney Dis 2019 Jan;13(1):71-72

Health Sciences University, Kayseri Training and Research Hospital, Pediatric Nutrition and Metabolism Clinic, Kayseri, Turkey.

A 6-year-old Syrian boy presented with complaints of facial dysmorphism and difficulty of walking. He had coarse face, macrocephaly, pectus carinatum, x-bain deformity, kyphosis, corneal clouding, and claw hand deformity. Galactose-6 sulphatase enzyme level was 0. Read More

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January 2019
11 Reads

Multicystic Dysplastic Kidney and Incontinentia Pigmenti: Coexistence of 2 Rare Diseases.

Iran J Kidney Dis 2019 Jan;13(1):67-70

Departments of Pediatric Nephrology, Mersin University Faculty of Medicine, Mersin, Turkey.

Multicystic dysplastic kidney is a congenital kidney malformation consisting of multiple cysts of various sizes without a normal kidney morphology. Incontinentia pigmenti is a rare X-linked dominant genodermatosis, which is usually lethal in males, that presents clinically in 4 stages. Here, we report a case of multicystic dysplastic kidney with ureterovesical junction obstruction and incontinentia pigmenti. Read More

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January 2019
4 Reads

Effect of Peritoneal Transport Characteristics on Clinical Outcome in Nondiabetic and Diabetic Nephropathy Patients with Peritoneal Dialysis.

Iran J Kidney Dis 2019 Jan;13(1):56-66

Department of Cardiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.

Introduction: This study aimed to investigate the influence of peritoneal transport characteristics on clinical outcome in nondiabetic and diabetic nephropathy peritoneal dialysis (PD) patients.

Materials And Methods: All 112 patients were from the PD Center. Peritoneal transport characteristic was assessed by peritoneal equilibration test. Read More

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January 2019
3 Reads

Prevalence of Protein-Energy Wasting and Its Association With Cardiovascular Disease Risk Factors in Iranian Peritoneal Dialysis Patients.

Iran J Kidney Dis 2019 Jan;13(1):48-55

Department of Clinical Nutrition and Dietetics, National Nutrition and Food Technology Research Institute, Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Introduction: Protein-energy wasting (PEW) is prevalent in dialysis patients, and cardiovascular disease (CVD) is the leading cause of mortality in these patients. This study aimed to determine the prevalence of PEW and its relationship with CVD risk factors in peritoneal dialysis (PD) patients in Tehran, Iran.

Materials And Methods: All eligible PD patients in Tehran peritoneal dialysis centers were included in this cross-sectional study. Read More

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January 2019
3 Reads

Comparisons of Three Main Treatments on Renoprotective Effects in Diabetes Mellitus.

Iran J Kidney Dis 2019 Jan;13(1):36-47

Department of Nephrology, the Second Affiliated Hospital of Nanchang University, Nanchang, China.

Introduction: Antihypertension, intensive glucose control (IGC), and lipid lowering were the main therapeutic strategies in diabetes mellitus. However, the comparative effects of them on renoprotection remain unclear.

Materials And Methods: We searched the PubMed, EMBase, and Cochrane Library up to May 18, 2017, for studies with comparative interventions on regression, end-stage renal disease and all-cause death in diabetes mellitus. Read More

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January 2019
2 Reads

Chronic Neurological Complications in Hemolytic Uremic Syndrome in Children.

Iran J Kidney Dis 2019 Jan;13(1):32-35

Department of Pediatrics, Iran University of Medical and Sciences, Tehran, Iran.

Introduction: Central nervous system (CNS) involvement is the most common extrarenal involvement in hemolytic uremic syndrome (HUS). There are limited reports on clinical cause of chronic neurologic problems in HUS. We evaluated residual neurologic involvement in children with HUS. Read More

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January 2019
14 Reads

Vitamin D Supplementation and Risk of Hypercalciuria in Stone Formers.

Iran J Kidney Dis 2019 Jan;13(1):27-31

Department of Nephrology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Introduction: Whether administrating of vitamin D supplements increases the risk of hypercalciuria is still unanswered. The aim of the present study was to determine whether use of vitamin D supplementation might increase the risk of hypercalciuria.

Methods And Materials: This interventional study was conducted on 30 who suffered from vitamin D insufficiency and deficiency and also had a history of nephrolithiasis. Read More

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January 2019
3 Reads

Renal Disorders in Pulmonary Sarcoidosis Patients.

Iran J Kidney Dis 2019 Jan;13(1):21-26

Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Introduction: The frequency of kidney disorders varies in pulmonary sarcoidosis patients. Since the prevalence of kidney disorders among Iranian sarcoidosis patients is uncertain, this study aimed to evaluate kidney disorders and associated manifestations in Iranian pulmonary sarcoidosis patients.

Materials And Methods: One hundred patients with confirmed granuloma as pulmonary sarcoidosis were studied for renal disorders. Read More

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January 2019
4 Reads
0.979 Impact Factor

Spotlights on Antibiotic-induced Acute Kidney Injury: the Evidence to Date.

Iran J Kidney Dis 2019 Jan;13(1):10-20

Department of Nephrology, the Second Affiliated Hospital of Nanchang University, China.

Acute kidney injury (AKI) is a frequent and wide complication of antibiotics therapy. In the present review article, we assessed the epidemiology, pathogenesis, risk factors, and clinical manifestation of antibiotic-induced AKI. The risk factors for the occurrence of antibiotic-induced AKI include medical comorbidities, coexisting drug therapies and the dosage, and therapeutic period of antibiotics. Read More

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January 2019
4 Reads

Burden, Access, and Disparities in Kidney Disease.

Iran J Kidney Dis 2019 01;13(1):1-9

Division of Nephrology, Department of Medicine; Welch Center for Prevention, Epidemiology and Clinical Research; and Johns Hopkins Center for Health Equity; Johns Hopkins Medical Institutions, Baltimore, Maryland, USA.

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January 2019
1 Read

Sofosbuvir and Daclatsvir in Treatment of Hepatitis C Virus-related Membranoproliferative Glomerulonephritis With Cryoglobulinemia in a Patient With Hepatitis C Genotype 4.

Iran J Kidney Dis 2018 Nov;12(6):382-384

Urology and Nephrology Center, Mansoura University, Egypt.

Direct antivirals showed dramatic response in hepatitis C virus (HCV) eradication, but their effect on extrahepatic manifestations is still unclear. A 49-year-old woman was referred to us suffering from lower limb edema and frothy urine. Renal biopsy was done and she was diagnosed with HCV-related membranoproliferative glomerulonephritis with cryoglobulinemia. Read More

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November 2018
4 Reads

C3 Glomerulonephritis With Multiple Mutations in Complement Factor H.

Iran J Kidney Dis 2018 Nov;12(6):376-381

Chronic Kidney Disease Research Center, Department of Nephrology, Labbafinejad Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Complement C3 glomerulopathy refers to a disease process in which abnormal control of complement activation or degradation results in predominant C3 fragment deposition within the glomerulus and causes glomerular damage. Abnormal control of the complement alternative pathway is a well-established risk factor for the occurrence of C3 glomerulonephritis. It is the first reported case in Iran with multiple mutations in complement factor H, with one of these mutations we have expected in hemolytic uremic syndrome rather than C3 glomerulopathy Genetic analysis showed that the molecular abnormalities of factor H led to complement factor H malfunction that were polymorphous and not restricted to the C-terminal domains of the protein. Read More

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November 2018
4 Reads
0.979 Impact Factor

Downregulation of Profibrotic Gene Expression by Angiotensin Receptor Blockers.

Iran J Kidney Dis 2018 Nov;12(6):369-375

Department of Internal Medicine, Aliebne Abitaleb Hospital, Zahedan University of Medical Sciences, Zahedan, Iran.

Introduction: Chronic allograft nephropathy is characterized by interstitial fibrosis and tubular atrophy. The main players in the process of fibrosis are transforming growth factor-β (TGF-β) and miR-21 expression with a bidirectional interplay. This study aimed to evaluate the effects of angiotensin receptor type 1 antagonist, losartan, on peripheral blood and tissue expression of TGF-β and miR-21 and histologic findings in allograft biopsy in kidney transplant recipients. Read More

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November 2018
3 Reads

Prevalence of Pulmonary Hypertension in End-stage Renal Disease Patients Undergoing Hemodialysis and Peritoneal Dialysis at a Referral Center in Mashhad, Iran, From 2015 to 2016.

Iran J Kidney Dis 2018 Nov;12(6):364-368

Departmentof Cardiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Introduction: Pulmonary artery hypertension is a serious comorbidityof dialysis in patients with end-stage renal disease. The prevalence of dialysis-induced pulmonary artery hypertension is still a subject of debate. The aim of this study was to determine the prevalence of pulmonary artery hypertension in patients undergoing hemodialysis and peritoneal dialysis. Read More

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November 2018
10 Reads

Treatment Effect of Ergocalciferol on Bone Metabolism Indexes and Parathyroid Hormone in Hemodialysis Patients.

Iran J Kidney Dis 2018 Nov;12(6):359-363

Department of Internal Medicine, Ardabil University of Medical Sciences, Ardabil, Iran.

Introduction: Vitamin D deficiency is a common problem in end-stage renal disease patients under hemodialysis. Both active and nutritional vitamin D supplementation have been recommended for its treatment. In this study we aimed to evaluate the effects of treatment with ergocalciferol on bone metabolism indexes in hemodialysis patients. Read More

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November 2018
3 Reads

Molecular Genetic Analysis of PKHD1 Mutations in Pedigrees With Autosomal Recessive Polycystic Kidney Disease.

Iran J Kidney Dis 2018 Nov;12(6):350-358

Department of Medical Genetics, Tarbiat Modares University, Teheran, Iran.

Introduction: A wide variety of mutations are spread throughout the PKHD1 gene, which encodes a 4074-bp amino acid protein, namely fibrocystin/polyductin, and is responsible for all features of autosomal recessive polycystic kidney disease (ARPKD). Autosomal recessive polycystic kidney disease is a hereditary early-onset form of polycystic kidney disease characterized by fusiform dilation of collecting ducts and congenital hepatic fibrosis. The highest level of PKDH1 expression is in the kidneys of fetus and adults, suggesting the functionally importance of the gene in the mature kidney in addition to its role in kidney development. Read More

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November 2018
2 Reads

TRPC6 Mutational Analysis in Iranian Children With Focal Segmental Glomerulosclerosis.

Iran J Kidney Dis 2018 Nov;12(6):341-349

Isfahan Kidney Diseases Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.

Introduction: Focal segmental glomerulosclerosis (FSGS) ranks among nephrotic syndromes. Research shows that FSGS is brought about by several genes including transient receptor potential cation channel subfamily c member 6 (TRPC6). This study aimed to investigate TRPC6 gene in Iranian FSGS children. Read More

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November 2018
6 Reads
0.979 Impact Factor

Brachial Artery Flow-mediated Dilatation and Carotid Intima-Media Thickness in Children With Idiopathic Nephrotic Syndrome.

Iran J Kidney Dis 2018 Nov;12(6):331-340

Department of Pediatrics, Faculty of Medicine, Zagazig University, Zagazig, Egypt.

Introduction: Disturbances of lipid metabolism has been reported in nephrotic syndrome (NS) and may predispose to atherosclerosis. This study aimed to investigate the correlation between cardiovascular risk factors and carotid intima-media thickness (CIMT) and brachial artery flow-mediated dilatation in patients with idiopathic NS.

Materials And Methods: This case-control study included 31 patients with NS and 31 healthy individuals as the control group. Read More

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November 2018
2 Reads

Cyclosporine in Pediatric Nephrology.

Iran J Kidney Dis 2018 Nov;12(6):319-330

Department of Pediatrics, Division Pediatric Nephrology, Medical Faculty of Dokuz Eylul University, Izmir, Turkey.

Cyclosporine began to be used as one of the immunosuppressive agents in transplantation in the beginning of the 1980s, and in the treatment of nephrotic syndrome in the pediatric nephrology. Therapeutic area of cyclosporine is narrow and its side effects limit its usage. Preference for cyclosporine and tacrolimus as a calcineurin inhibitor is left for the choice of the department. Read More

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November 2018
8 Reads

Successful Treatment of Posttransplant Recurrent Complement C3 Glomerulopathy with Eculizumab.

Iran J Kidney Dis 2018 Oct;12(5):315-318

Department of Nephrology, Diskapi Yildirim Beyazit Education and Research Hospital, Ankara, Turkey.

Two-thirds of complement C3 glomerulopathy (C3G) recur after transplantation and commonly cause graft loss. There is not a standard treatment protocol for these cases. We present a kidney transplant patient with recurrent C3G who was successfully treated with eculizumab. Read More

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October 2018
26 Reads

Cutaneous Infection With Mycobacterium haemophilum in an Immunocompromised Patient.

Iran J Kidney Dis 2018 Oct;12(5):312-314

Infectious Diseases and Tropical Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Mycobacterium haemophilum is a fastidious nontuberculosis Mycobacterium that must be considered in the differential diagnosis of infections in immunocompromised patients. Mycobacterium haemophilum typically is a pathogen of the cutaneous or subcutaneous tissue and also presents as septic arthritis, osteomyelitis, pulmonary disease, and lymphadenitis. We report a 32-year-old man with past medical history of kidney transplantation, endocarditis, gastrointestinal bleeding, and hypertension, complaining of multiple painful nodular lesions since 3 months earlier. Read More

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October 2018
23 Reads

Association of Forkhead Box P3 Gene Polymorphisms With Allograft Rejection Episodes in Kidney Transplant Patients: a Study From Kashmir, North India.

Iran J Kidney Dis 2018 Oct;12(5):305-311

Department of Neprology, Sher i Kashmir Institute of Medical Sciences, Soura Srinagar J and K, India.

Introduction: The forkhead box P3 (FOXP3) gene is important for regulation and development of T cells, which are mediators of kidney allograft rejection. The FOXP3 gene polymorphism may be associated with the rejection of kidney transplants. This study was designed to determine the association of FOXP3 polymorphism with kidney transplant rejection. Read More

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October 2018
23 Reads
0.980 Impact Factor

Serum Matrix Metalloproteinase-9, Tissue Inhibitor of Metalloproteinase-1 and Matrix Metalloproteinase-9/ Neutrophil Gelatinase-associated Lipocalin Complex Levels in Patients With Early-stage Diabetic Nephropathy.

Iran J Kidney Dis 2018 Oct;12(5):299-304

Department of Biochemistry, Sanliurfa Mehmet Akif Inan Training and Research Hospital, Sanliurfa, Turkey.

Introduction: This study was aimed to investigate the efficacy of matrix metalloproteinase-9 (MMP-9), tissue inhibitor of metalloproteinase-1 (TIMP-1), and the neutrophil gelatinase-associated lipocalin (NGAL)-bound form of MMP-9 (MMP-9/NGAL complex) markers in the determination of early nephropathy in patients with type 2 diabetes mellitus.

Materials And Methods: Twenty-five type 2 diabetic patients with normoalbuminuria, 27 type 2 diabetic patients with microalbuminuria, and 23 healthy controls were recruited. Serum levels of MMP-9, TIMP-1, and MMP9/NGAL complex were measured in all participants. Read More

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October 2018
16 Reads

Myocardial Function in Egyptian Pediatric Patients With Acute Nephritic Syndrome.

Iran J Kidney Dis 2018 Oct;12(5):293-298

Department of Pediatrics, Faculty of Medicine, Tanta University, Tanta, Egypt.

Introduction: Acute nephritic syndrome (ANS) is the most common cause of hypertensive heart failure in pediatric population. There are few publications on myocardial evaluation using electrocardiographic and echocardiographic data in pediatric patients with ANS. This study aimed to evaluate myocardial function by electrocardiography and 2-dimensional echocardiography in Egyptian pediatric patients with ANS. Read More

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October 2018
2 Reads

Efficacy and Safety of Mycophenolate Mofetil Versus Intravenous Pulse Cyclophosphamide as Induction Therapy in Proliferative Lupus Nephritis.

Iran J Kidney Dis 2018 Oct;12(5):288-292

Connective Tissue Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Introduction: Lupus nephritis is a common and severe manifestation of systemic lupus erythematosus that can lead to end-stage renal disease and death. The aim of this study was to compare the efficacy and safety of mycophenolate mofetil (MMF) and cyclophosphamide as induction therapy and subsequently as maintenance therapy for lupus nephritis.

Materials And Methods: In this retrospective case-control study, 67 patients with proliferative lupus nephritis who were treated with MMF (n = 45) and pulse of intravenous cyclophosphamide (n = 22) were included. Read More

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October 2018
18 Reads

Effect of Sevelamer on Serum Levels of Klotho and Soluble Tumor Necrosis Factor-like Weak Inducer of Apoptosis in Rats With Adenine-induced Chronic Kidney Disease.

Iran J Kidney Dis 2018 Oct;12(5):281-287

Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Introduction: Nontraditional risk factors for cardiovascular disease (CVD), including mineral disorder, high fibroblast growth factor 23 (FGF23), low klotho, and low soluble TWEAK could predict the incipient risk of CVD in chronic kidney disease (CKD). The present study evaluates the effect of sevelamer on soluble tumor necrosis factor-like weak inducer of apoptosis (TWEAK), and klotho levels in adenine-induced CKD rats.

Methods And Materials: Normal control rats without sevelamer were compared with 3 groups of adenine-induced CKD rats, including CKD rats without sevelamer, CKD rats treated with 3% sevelamer, and rats receiving adenine and 3% sevelamer concurrently. Read More

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October 2018
8 Reads

Association of Vitamin D Deficiency with Increased Pulse Wave Velocity and Augmentation Index in Children With Chronic Kidney Disease.

Iran J Kidney Dis 2018 Oct;12(5):275-280

Ege University Faculty of Medicine, Department of Pediatric Nephrology, ?zmir, Turkey.

Introduction: It is known that in children with chronic kidney disease (CKD), cardiovascular damage starts in the form of arterial stiffness. There are risk factors other than the traditional ones such as arterial stiffness hypertension, obesity, hypercholesterolemia, and insulin resistance. Vitamin D deficiency is rather common in CKD, and it was introduced as a risk factor for atherosclerosis; however, its relationship with arterial stiffness is not known completely. Read More

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October 2018
16 Reads

Prevalence and Associated Factors of Chronic Kidney Disease Among Patients Infected With Human Immunodeficiency Virus in Cameroon.

Iran J Kidney Dis 2018 Oct;12(5):268-274

Department of Internal Medicine, Douala General Hospital; Faculty of Medicine and Pharmaceutical Sciences, University of Douala; Douala, Cameroon.

Introduction: Chronic kidney disease (CKD) is frequent amongst human immunodeficiency virus (HIV)-positive patients, and screening is not routinely performed in Sub-Saharan Africa due to resource constraints. We aimed to determine the prevalence of CKD and associated factors in HIV-infected patients in Cameroon.

Materials And Methods: A cross-sectional study in Northern Cameroon included HIV-positive patients who attended the HIV clinic. Read More

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October 2018
24 Reads

Acute Kidney Injury Risk Recognition in Resource-Sufficient Versus Resource-Limited Regions.

Iran J Kidney Dis 2018 Oct;12(5):261-267

Division of Nephrology and Hypertension; Division of Pulmonary and Critical Care Medicine; Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA.

Acute kidney injury is a very common complication of acute illnesses with dire consequences. There are significant differences in incidence, etiology, severity, and clinical impact of acute kidney injury between resource-sufficient and resource-limited regions. Awareness of such differences would potentially allow clinicians and policymakers to devise and provide region-specific interventions to decrease the incidence of acute kidney injury and mitigate its complications. Read More

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October 2018
7 Reads

Potential Adverse Effects of Creatine Supplement on the Kidney in Athletes and Bodybuilders.

Iran J Kidney Dis 2018 10;12(5):253-260

Department of Clinical Pharmacy, Faculty of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.

Introduction: Nowadays, creatine is one of the most common oral supplements used by professional athletes for boosting their strength and muscle mass. In this review, we collect available experimental and clinical data about renal safety of both short-term and long-term use of creatine.

Materials And Methods: Scientific literature was critically searched by keywords "creatine," "renal insufficiency," and "renal dysfunction" and their synonyms in medical databases (Scopus, MEDLINE, EMBase, and ISI Web of Knowledge). Read More

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October 2018
19 Reads

Myocardial Infarction-triggered Thrombotic Microangiopathy.

Iran J Kidney Dis 2018 07;12(4):250-251

Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

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July 2018
2 Reads
0.980 Impact Factor

A Case of Acrorenal Syndrome.

Iran J Kidney Dis 2018 07;12(4):247-249

Cellular and Molecular Biology Research Center; Cancer Research Center; Health Research Institute; Clinical Research Development Center, Shahid Beheshti Hospital; Department of Internal Medicine, School of Medicine; Babol University of Medical Sciences, B.

Urinary tract anomalies are common and comprise about 20% to 30% of total congenital anomalies. This spectrum consists of many different anomalies of the urinary tract that may be syndromic or nonsyndromic with different etiologies. In this case report, a patient with single kidney and urinary tract signs is introduced that was diagnosed accidentally. Read More

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July 2018
2 Reads

Immunoglobulin G4-related Kidney Disease Associated With Autoimmune Hemolytic Anemia.

Iran J Kidney Dis 2018 07;12(4):243-246

Renal Division, Department of Medicine, West China Hospital of Sichuan University, Chengdu, China.

Awareness of the uncommon associated clinical manifestations of immunoglobulin G4 (IgG4)-related kidney disease is essential for the early diagnosis and effective treatment of patients. To the best of our knowledge, there have been few reports of patients with IgG4-related kidney disease associated with autoimmune hemolytic anemia. We here report a rare case of IgG4-related kidney disease associated with autoimmune hemolytic anemia. Read More

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July 2018
7 Reads

Molecular Study of Nephronophthisis in 7 Unrelated Pakistani Families.

Iran J Kidney Dis 2018 07;12(4):240-242

Medical Genetics Research Laboratory, Department of Biotechnology, Quaid-I-Azam University, Islamabad, Pakistan.

Nephronophthisis is an autosomal recessive cystic kidney disease characterized by tubular interstitial infiltration, periglomerular fibrosis, and cysts, and is the most frequent genetic cause of end-stage renal disease in children. Nephronophthisis is pleiotropic as almost all the causative genes are involved in primary cilium and centrosome function which are found in almost all human cells. Genetic heterogeneity in nephronophthisis makes the molecular and genetic diagnosis somewhat difficult. Read More

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July 2018
4 Reads

Correlation of Caveolin-1 With Vascular Intimal Thickness for Different Locations of Catheter Tips in a Dog Model.

Iran J Kidney Dis 2018 07;12(4):232-239

Department of Kidney Disease and Blood Purification Centre, Institute of Urology and Key Laboratory of Tianjin, 2nd Hospital of Tianjin Medical University, Tianjin, China.

Introduction: Many studies have reported increased intimal thickness around the catheter tip after catheterization. Caveolin-1 is a protein in the endothelial cell that acts as a shear sensor causing vascular remodeling. This study aimed to elucidate the suitability of different catheter locations and determine the role of caveolin-1 in canine models. Read More

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July 2018
5 Reads

Vitamin D Receptor Gene Polymorphisms and Environment Influencing the Impact on Survival in Hemodialysis Patients.

Iran J Kidney Dis 2018 07;12(4):223-231

School of Life Sciences, Pontifícia Universidade Católica do Paraná, Curitiba, Brazil.

Introduction: The vitamin D-receptor axis is involved in multiple physiological functions and altered states such as hypertension, mineral metabolism disorders, and inflammation. These disturbances are major risk factors for progression to end-stage kidney disease and cardiovascular disease. In addition, changes in internal systemic environment could be influencing the impact of survival in patients with kidney disease. Read More

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July 2018
13 Reads

Effects of Flaxseed Oil on Serum Bone Turnover Markers in Hemodialysis Patients: a Randomized Controlled Trial.

Iran J Kidney Dis 2018 07;12(4):215-222

Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Introduction: Chronic kidney disease-mineral and bone disorder is a common complication in hemodialysis patients. The present study was designed to investigate the effects of flaxseed oil, a rich source of plant omega-3 fatty acid alpha-linolenic acid, on serum markers of bone formation and resorption in hemodialysis patients.

Materials And Methods: In this randomized controlled trial, 34 hemodialysis patients were randomly assigned to either the flaxseed oil or the control group. Read More

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July 2018
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Serum Apelin Peptide Level in Hemodialysis Patients With Pulmonary Arterial Hypertension.

Iran J Kidney Dis 2018 07;12(4):209-214

Department of Internal Medicine, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran.

Introduction: Pulmonary arterial hypertension (PAH) is a destructive disease that is characterized by vasoconstriction, alterations and abnormal angiogenesis in pulmonary vessels, and right ventricular dysfunction. There is no certain treatment known for this condition. Patients with PAH have a lower level of apelin in their blood and less apelin is secreted in their endothelial cells, but this condition is not investigated in hemodialysis patients. Read More

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July 2018
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Alkaline Diet: a Novel Nutritional Strategy in Chronic Kidney Disease?

Iran J Kidney Dis 2018 07;12(4):204-208

Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Science, Tehran, Iran.

Chronic kidney disease is defined as a glomerular filtration rate lower than 60 mL/min/1.73 m2, which is regarded as a public health priority and part of the growing burden of noncommunicable diseases. Reduced kidney function is concomitant with high levels of inflammatory factors, abnormal lipid profile, and anemia, as well as bone abnormalities, calcium deposition outside the bones, endothelial dysfunction, and cardiomyopathy. Read More

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July 2018
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End-stage Renal Disease in the Middle East: a Systematic Review and Meta-analysis.

Iran J Kidney Dis 2018 07;12(4):195-203

Shiraz Nephro-Urology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Introduction: End-stage renal disease (ESRD) results in unpleasant consequences for patients, their families, and also society. Annually, each country expends a huge amount for ESRD treatment. In addition, its prevalence is dramatically growing, though it can be prevented. Read More

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July 2018
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