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    1 OF 111

    Vitamin A, endocrine tissues and hormones: interplay and interactions.
    Endocr Connect 2017 Jul 18. Epub 2017 Jul 18.
    J Corcuff, Nuclear Medicine, University hospital of Bordeaux, Pessac, 33604, France
    Vitamin A (retinol) is a micronutrient critical for cell proliferation and differentiation. In adults, vitamin A and metabolites such as retinoic acid (RA) play major roles in vision, immune and brain functions, and tissue remodelling and metabolism. This review presents the physiological interactions of retinoids and endocrine tissues and hormonal systems. Read More

    Are lower TSH cutoffs in neonatal screening for congenital hypothyroidism warranted? A debate.
    Eur J Endocrinol 2017 Jul 10. Epub 2017 Jul 10.
    G Van Vliet, Peditarics, Ste-Justine Hospital, Montreal, H3T 1C5, Canada.
    When newborn screening (NBS) for congenital hypothyroidism (CH) using thyroid stimulating hormone (TSH) as a primary screening test was introduced, typical TSH screening cutoffs were 20 to 50 mU/L of whole blood. Over the years, lowering of TSH cutoffs has contributed to an increased prevalence of detected CH. However, a consensus on the benefit deriving from lowering TSH cutoffs at screening is lacking. Read More

    Are Low Intakes and Deficiencies in Iron, Vitamin A, Zinc, and Iodine of Public Health Concern in Ethiopian, Kenyan, Nigerian, and South African Children and Adolescents.
    Food Nutr Bull 2017 Jan 1:379572117715818. Epub 2017 Jan 1.
    1 Unilever Research and Development, Vlaardingen, the Netherlands.
    Objective: To perform a systematic review to evaluate iron, vitamin A, zinc, and iodine status and intakes in children and adolescents (0-19 years) in Ethiopia, Kenya, Nigeria, and South Africa.

    Method: Both national and subnational data published from the year 2005 to 2015 were searched via MEDLINE, Scopus, and national public health websites. For each micronutrient and country, status data from relevant studies and surveys were combined into an average prevalence and weighted by sample size (WAVG). Read More

    Boron - A potential goiterogen?
    Med Hypotheses 2017 Jul 26;104:63-67. Epub 2017 May 26.
    Yaroslavl State University, Yaroslavl, Russia; RUDN University, Moscow, Russia; Orenburg State University, Orenburg, Russia.
    The iodine deficiency disorders (IDD) include a variety of disturbances such as decreased fertility, increased perinatal and infant mortality, impaired physical and intellectual development, mental retardation, cretinism, hypothyroidism, and endemic goiter (EG). The occurrence of the latter is determined by interplay between genetic and environmental factors. The major environmental factor is iodine status that is required for normal thyroid hormone synthesis. Read More

    Newborn Screening for Thyroid-stimulating Hormone as an Indicator for Assessment of Iodine Status in the Republic of Macedonia.
    J Med Biochem 2016 Oct 2;35(4):385-389. Epub 2016 Nov 2.
    Laboratory for Neonatal Thyroid Screening, Department of Endocrinology and Genetics, University Children's Hospital, Skopje, Republic of Macedonia.
    Background: Iodine deficiency is associated with goiter and impaired brain function leading to cretinism. An increased frequency of thyroid-stimulating hormone (TSH) measurements above 5 mlU/L on newborn screening points toward an impaired iodine status of the population.

    Methods: A 13-year retrospective analysis was performed in 228,266 newborns participating in the national thyroid newborn screening program. Read More

    First Israeli national iodine survey demonstrates iodine deficiency among school aged children and pregnant women.
    Thyroid 2017 Jun 28. Epub 2017 Jun 28.
    The Hebrew University of Jerusalem, The Institute of Biochemistry Food and Nutrition Science , Herzl Street , PO BOX 12 , Rehovot, Please Select, Israel , 76100 ;
    Introduction: National data on iodine status in Israel is lacking. Reliance on iodine-depleted desalinated water, the absence of a salt iodization program and reports of increased use of thyroid medication in Israel suggested that the population's iodine intake is likely inadequate.

    Aims: To determine iodine status of Israeli school age children (SAC) and pregnant women (PW) in a nationally-representative sample obtained by a novel approach of using pre-discard urinalysis samples collected from a centralized national laboratory. Read More

    A PRISMA-compliant systematic review and meta-analysis of the relationship between thyroid disease and different levels of iodine intake in mainland China.
    Medicine (Baltimore) 2017 Jun;96(25):e7279
    Department of Nuclear Medicine, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
    Background: Low-iodine intake has historically been an issue in China, causing widespread iodine deficiency diseases (IDD). China started to introduce universal salt iodization in 1995, but reports of increased thyroid disease are a concern and appropriate levels of iodine intake must be considered.

    Objective: To assess the prevalence of thyroid disease with different urinary iodine concentrations (UICs) in the general population of those residing in mainland China. Read More

    Kikuchi-Fujimoto disease: a case report of a multi-drug resistant, grueling disease.
    Oxf Med Case Reports 2017 Jun 15;2017(6):omx024. Epub 2017 Jun 15.
    Pathology Department, Faculty of Medicine, Tishreen University, Lattakia, Syria.
    Histiocytic necrotizing lymphadenitis or Kikuchi-Fujimoto disease (KFD) is characterized by its rare occurrence. Mostly prevalent among Asian women, KFD manifests with lymphadenopathy-affecting mostly cervical and rarely generalized or retroperitoneal regions-in addition to fever. It is a self-limited disease that resolves within 1-4 months, responding remarkably to glucocorticosteroids or hydroxychloroquine. Read More

    Digenic DUOX1 and DUOX2 mutations in cases with congenital hypothyroidism.
    J Clin Endocrinol Metab 2017 Jun 16. Epub 2017 Jun 16.
    Metabolic Research Laboratories, Wellcome Trust-Medical Research Council Institute of Metabolic Science, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK.
    Context: The DUOX2 enzyme generates hydrogen peroxide (H2O2), a crucial electron acceptor for the TPO-catalyzed iodination and coupling reactions mediating thyroid hormone biosynthesis. DUOX2 mutations result in dyshormonogenetic Congenital Hypothyroidism (CH) which may be phenotypically heterogeneous, leading to the hypothesis that CH severity may be influenced by environmental factors (eg dietary iodine) and oligogenic modifiers (eg variants in the homologous NADPH-oxidase DUOX1). However, loss of function mutations in DUOX1 have not hitherto been described and its role in thyroid biology remains undefined. Read More

    Spectrophotometric Determination of Selenium Through Triiodide Anion.
    Clin Lab 2017 May;63(5):887-899
    Background: Selenium is a chemical element found in the human body that plays a crucial role in its regulation. Depending on the concentration, it may have beneficial or have toxic effects. Selenium is incorporated as selenocysteine amino acid residue in selenoproteins which play an important role in many biological functions: anti-oxidant defense, regulation of the immune function and of the inflammatory response, metabolism of thyroid hormones, functioning of the central nervous system, biosynthesis of DNA and RNA, fertility, and reproduction. Read More

    Iodine levels are associated with oxidative stress and antioxidant status in pregnant women with hypertensive disease
    Nutr Hosp 2017 06 5;34(3):661-666. Epub 2017 Jun 5.
    instituto de salud publica, universidad veracruzana.
    Background: The antioxidant function of iodine and iodine deficiency as a risk factor of preeclampsia have been previously reported.

    Aim: To analyze the association between iodine deficiency, oxidative stress and antioxidant status with hypertensive disease of pregnancy (HPD).

    Method: Fifty-seven pregnant women were recruited in the last trimester of pregnancy; 20 were diagnosed with hypertensive disease (HPD) of pregnancy and 37 were normotensive pregnant women. Read More

    Identification of Organic Iodine Compounds and Their Transformation Products in Edible Iodized Salt Using Liquid Chromatography-High Resolution Mass Spectrometry.
    J Agric Food Chem 2017 Jul 26;65(26):5384-5389. Epub 2017 Jun 26.
    State Key Laboratory of Biogeology and Environmental Geology, China University of Geosciences , Wuhan, 430074, P. R. China.
    The consumption of edible iodized salt is a key strategy to control and eliminate iodine deficiency disorders worldwide. We herein report the identification of the organic iodine compounds present in different edible iodized salt products using liquid chromatography combined with high resolution mass spectrometry. A total of 38 organic iodine compounds and their transformation products (TPs) were identified in seaweed iodine salt from China. Read More

    Intrauterine death following intraamniotic triiodothyronine and thyroxine therapy for fetal goitrous hypothyroidism associated with polyhydramnios and caused by a thyroglobulin mutation.
    Endocrinol Diabetes Metab Case Rep 2017 7;2017. Epub 2017 Jun 7.
    University of Cambridge Metabolic Research Laboratories, Wellcome Trust-Medical Research Council Institute of Metabolic Science, Addenbrooke's Hospital, CambridgeUK.
    In the absence of maternal thyroid disease or iodine deficiency, fetal goitre is rare and usually attributable to dyshormonogenesis, for which genetic ascertainment is not always undertaken in the UK. Mechanical complications include tracheal and oesophageal compression with resultant polyhydramnios, malpresentation at delivery and neonatal respiratory distress. We report an Indian kindred in which the proband (first-born son) had congenital hypothyroidism (CH) without obvious neonatal goitre. Read More

    Endemic goitre and hypothyroidism in an adult female patient dependent on total parenteral nutrition.
    Endocrinol Diabetes Metab Case Rep 2017 7;2017. Epub 2017 Jun 7.
    Departments of Endocrinology.
    We present the case of a thirty-year-old female patient who was referred to the endocrinology team with an enlarging goitre and biochemical hypothyroidism. She had been dependent on total parenteral nutrition for the previous six years as a result of intestinal failure thought to be caused by possible underlying mitochondrial disease. The patient also suffers from a Desmin myopathy, and at present, the exact aetiology behind her intestinal failure is not certain. Read More

    Daily Consumption of Lipid-Based Nutrient Supplements Containing 250 μg Iodine Does Not Increase Urinary Iodine Concentrations in Pregnant and Postpartum Women in Bangladesh.
    J Nutr 2017 Jun 14. Epub 2017 Jun 14.
    Department of Nutrition, University of California, Davis, Davis, CA; and Divisions of.
    Background: Maternal iodine deficiency during pregnancy and lactation is common in Bangladesh.Objective: We evaluated the effect of lipid-based nutrient supplements for pregnant and lactating women (LNS-PL) on urinary iodine concentration (UIC).Methods: We conducted a cluster-randomized controlled effectiveness trial in which we enrolled 4011 pregnant women at ≤20 gestational weeks. Read More

    Thirty-Five Years of Thyroid Cancer Experience in a Paediatric Population: Incidence Trends in Lithuania between 1980 and 2014.
    Eur Thyroid J 2017 Feb 9;6(1):40-46. Epub 2016 Nov 9.
    Clinic of Endocrinology, Lithuanian University of Health Sciences, Kaunas, Lithuania.
    Background: Thyroid cancer (TC) is a rare condition in children. It may be associated with radiation, iodine deficiency or familial inheritance.

    Aims: The objectives of this study were to analyse the prevalence and incidence trends over 3 decades and clinical features of TC in the paediatric population in Lithuania. Read More

    Pregnant Greek Women May Have a Higher Prevalence of Iodine Deficiency than the General Greek Population.
    Eur Thyroid J 2017 Feb 28;6(1):26-30. Epub 2016 Sep 28.
    Division of Endocrinology, University Medical School, University Hospital, Rion-Patras, Greece.
    Background: Adequate dietary iodine consumption, predicted via the urinary iodine concentration (UIC), is necessary for normal thyroid function and for the neurodevelopment of fetuses and neonates. The general population of Greece is considered to be iodine sufficient, but our preliminary findings suggest that Greek pregnant women are at risk of iodine deficiency.

    Objective: Our aim was to estimate the thyroid function and UIC in a representative population of pregnant Greek women. Read More

    Maternal Different Degrees of Iodine Deficiency during Pregnant and Lactation Impair the Development of Cerebellar Pinceau in Offspring.
    Front Neurosci 2017 29;11:298. Epub 2017 May 29.
    Department of Occupational and Environmental Health, School of Public Health, China Medical UniversityShenyang, China.
    Aims: Iodine is critical for synthesis of thyroid hormones (TH). And iodine deficiency (ID) is one of the most significant reasons of intellectual disability and motor memory impairment, although the potential mechanisms are still under investigation. Presently, mild ID and marginal ID are largely ignored problems for women of child bearing age. Read More

    Iodine Prophylaxis In The Lights Of The Last Recommendation Of Who On Reduction Of Daily Salt Intake.
    Recent Pat Endocr Metab Immune Drug Discov 2017 Jun 8. Epub 2017 Jun 8.
    Department of Endocrinology, Jagiellonian University, Collegium Medicum, Krakow. Poland.
    In 1994 international organizations: WHO,UNICEF and ICCIDD indicated salt - Natrium Chloride as a main carrier of iodine in the prophilaxis systems in the iodine deficient areas over the world. Following this recommendation 24 European countries introduced the model of iodine prophylaxis based on the salt iodization. However in 7 European countries only - among them in Poland - salt iodization is mandatory -as the most effective model on the population level. Read More

    Thyroglobulin level at week 16 of pregnancy is superior to urinary iodine concentration in revealing preconceptual and first trimester iodine supply.
    Matern Child Nutr 2017 Jun 7. Epub 2017 Jun 7.
    Division of Endocrinology, Department of Medicine, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
    Pregnant women are prone to iodine deficiency due to the increased need for iodine during gestation. Progress has recently occurred in establishing serum thyroglobulin (Tg) as an iodine status biomarker, but there is no accepted reference range for iodine sufficiency during pregnancy. An observational study was conducted in 164 pregnant women. Read More

    Consumption of Fish Is Not Associated with Risk of Differentiated Thyroid Carcinoma in the European Prospective Investigation into Cancer and Nutrition (EPIC) Study.
    J Nutr 2017 Jul 7;147(7):1366-1373. Epub 2017 Jun 7.
    International Agency for Research on Cancer, Lyon, France.
    Background: Differentiated thyroid cancer (TC) is the most common endocrine cancer. Fish can be an important source of iodine and other micronutrients and contaminants that may affect the thyroid gland and TC risk.Objective: We prospectively evaluated the relations between the consumption of total fish and different fish types and shellfish and TC risk in the EPIC (European Prospective Investigation into Cancer and Nutrition) study. Read More

    The influence of mandatory iodine fortification on the iodine status of Australian school children residing in an iodine sufficient region.
    Asia Pac J Clin Nutr 2017 ;26(4):680-685
    Children's Nutrition Research Centre, Child Health Research Centre, The University of Queensland, South Brisbane, Australia.
    Background And Objectives: To counter emerging iodine deficiency mandatory iodine fortification of bread was introduced throughout Australia in 2009. This study investigated the impact of iodine fortification on the iodine status of school aged children living in the iodine replete state of Queensland, and investigated which foods had greatest influence on overall iodine status.

    Methods And Study Design: A convenience sample of 30 children aged 8. Read More

    Nutritional status and dietary diversity of Kamea in Gulf Province, Papua New Guineas.
    Asia Pac J Clin Nutr 2017 ;26(4):665-670
    Micronutrient Research Laboratory, Division of Basic Medical Sciences, School of Medicine and Health Sciences, University of Papua New Guinea, Papua New Guinea.
    Background And Objectives: To assess the nutritional status of infants, children and non-pregnant women and underlying factors, dietary diversity and community food security, in the Kamea community in Gulf Province, Papua New Guinea.

    Methods And Study Design: Prospective cross sectional study. Study population 69 infants (0-59 months), 151 children (6-12 years) and 79 non-pregnant women from 10 villages in Kotidanga Local Level Government, Kerema District, Gulf Province, Papua New Guinea. Read More

    Role of medical resource level in iodine deficiency disorder.
    Mil Med Res 2017 1;4:18. Epub 2017 Jun 1.
    Department of Military Medical Geography, College of High Altitude Military Medicine, Third Military Medical University, Chongqing, 400038 China.
    Background: Iodine deficiency disorders (IDDs) refer to a series of diseases caused by the human body's insufficient iodine intake. Edible salt became iodized in China in 1996, which yielded remarkable results. We have known that IDDs is associated with iodine in the human body, but it is not clear whether IDDs is related to medical resource level. Read More

    Dynamic Changes in the Bivariable Distribution of Urinary Iodine Concentration and Thyroid Volume in Children Aged 8 to 10 Years in China.
    Asia Pac J Public Health 2017 May;29(4):288-295
    1 Harbin Medical University, Harbin, HL, China.
    National iodine-deficiency disorder surveillance surveys were conducted in 1999, 2005, and 2011 in China. Probability-proportional-to-size sampling technique was used to select sampling units. The mean of thyroid volume (Tvol) in the 100 to 199 µg/L UIC (urinary iodine concentration) group was significantly lower than that in the 200 to 299 µg/L UIC group in 2011 ( P < . Read More

    Thyroid homeostasis in mother-child pairs in relation to maternal iodine status: the MISA study.
    Eur J Clin Nutr 2017 May 24. Epub 2017 May 24.
    Department of Community Medicine, UiT, The Arctic University of Norway, Tromsø, Norway.
    Background/objectives: Iodine deficiency during pregnancy may influence maternal and foetal thyroid function with the risk of causing neurocognitive and psychomotor deficits in the offspring. The objective of this study was to assess iodine status in pregnant women from Northern Norway and to investigate the influence of iodine status on maternal and infant thyroid function.

    Subjects/methods: Women from the Northern Norway Mother-and-Child contaminant Cohort Study (MISA) donated a blood and urine sample at three visits during their pregnancy and postpartum period (in second trimester, 3 days and 6 weeks after delivery. Read More

    The dietary composition of women who delivered preterm and full-term infants.
    Appl Nurs Res 2017 Jun 3;35:13-17. Epub 2017 Feb 3.
    Faculty of Health Sciences, Department of Nursing and Emergency Medicine, University of Bielsko-Biala, ul. Willowa 2, 43-309 Bielsko-Biala, Poland.
    Objectives: Literature data show that excess and primary deficiency in particular nutrients, vitamins and minerals may lead to pre-eclampsia, gestational diabetes, hypertension and neural tube defects in the foetus. The aim of the study was to determine differences in average daily consumption of selected nutrients during pregnancy in women who did not supplement their diet and to evaluate the influence of dietary habits on the occurrence of pre-term delivery and hypertension in pregnant women.

    Sample Group And Methods: Information on the course of pregnancy and the newborn's health status at birth was derived from the Charter of Pregnancy and documents recorded by the hospital. Read More

    Harefuah 2016 Aug;155(8):470-474
    Department of Internal Medicine C, Barzilai Medical Center Ashkelon, Israel.
    Aims: The aim of this study was to describe thyroglobulin levels and iodine intake estimations in a convenience sample of Israeli adults without TD in the Ashkelon District, where SWRO desalination has become the major source of drinking water.

    Background: Iodine deficiency (ID) is a significant risk factor for thyroid disease (TD). Recently, there were increases in both selfreported use of TD medication among Israeli adults and the national use of sea water reverse osmosis (SWRO) desalinated water. Read More

    Suboptimal Maternal Iodine Intake Is Associated with Impaired Child Neurodevelopment at 3 Years of Age in the Norwegian Mother and Child Cohort Study.
    J Nutr 2017 Jul 17;147(7):1314-1324. Epub 2017 May 17.
    Infection Control and Environmental Health and
    Background: Severe iodine deficiency in pregnancy has major effects on child neurodevelopment, but less is known about the potential consequences of mild-to-moderate deficiency and iodine supplement use.Objective: We explored the associations between maternal iodine intake and child neurodevelopment at 3 y of age and the potential impact of maternal intake of iodine from supplements on the same outcomes.Methods: This population-based prospective observational study included 48,297 mother-child pairs recruited during pregnancy from 2002 to 2008. Read More

    [Dynamics of immunological features of oral liquid in children with chronic catarrhal gingivitis living on polluted territories with fluoride and iodine deficiency].
    Stomatologiia (Mosk) 2017;96(2):51-54
    Danylo Halytsky Lviv National Medical University, Lviv, Ukraine.
    The aim of the study was to assess the state of oral liquid (OL) immunity in children with chronic catarrhal gingivitis (CCG) living in adverse environmental conditions. 120 children aged 7-15 residing in ecologically unfavorable areas of Lviv region were examined, while 75 children living in 'relatively clean' region were involved in the control group. Chronic catarrhal gingivitis was diagnosed according to Danilevskiy classification (1994). Read More

    Interventions for cutaneous molluscum contagiosum.
    Cochrane Database Syst Rev 2017 05 17;5:CD004767. Epub 2017 May 17.
    Department of General Practice, Erasmus Medical Center, PO Box 2040, Room Ff303, Rotterdam, Netherlands, 3000 CA.
    Background: Molluscum contagiosum is a common skin infection that is caused by a pox virus and occurs mainly in children. The infection usually resolves within months in people without immune deficiency, but treatment may be preferred for social and cosmetic reasons or to avoid spreading the infection. A clear evidence base supporting the various treatments is lacking. Read More

    Factors associated with serum thyroglobulin in a Ukrainian cohort exposed to iodine-131 from the accident at the Chernobyl Nuclear Plant.
    Environ Res 2017 Jul 12;156:801-809. Epub 2017 May 12.
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States.
    Background: Serum thyroglobulin (Tg) is associated with the presence of thyroid disease and has been proposed as a biomarker of iodine status. Few studies have examined factors related to serum Tg in populations environmentally exposed to ionizing radiation and living in regions with endemic mild-to-moderate iodine deficiency.

    Methods: We screened 10,430 individuals who were living in Ukraine and under 18 years of age at the time of the 1986 Chernobyl Nuclear Power Plant accident for thyroid disease from 2001 to 2003. Read More

    Knowledge about Iodine in Pregnant and Lactating Women in the Oslo Area, Norway.
    Nutrients 2017 May 13;9(5). Epub 2017 May 13.
    Department of Nursing and Health Promotion, Faculty of Health Sciences, Oslo and Akershus University College of Applied Sciences, 0130 Oslo, Norway.
    Background: Lack of knowledge about iodine may be a risk factor for iodine deficiency in pregnant and lactating women. The aim of this study was to assess knowledge about iodine and predictors of iodine knowledge scores among pregnant and lactating women. The study also examined whether iodine knowledge scores were associated with iodine status. Read More

    Temporal trends in thyroid-stimulating hormone (TSH) and thyroid peroxidase antibody (ATPO) testing across two phases of iodine fortification in Tasmania (1995-2013).
    Clin Endocrinol (Oxf) 2017 May 13. Epub 2017 May 13.
    Department of Diabetes & Endocrinology, Royal Hobart Hospital, Hobart, Tasmania.
    Context: Tasmania is an island state of the Australian Commonwealth with a well-documented history of mild iodine deficiency. Between 2001 and 2009, Tasmania experienced two incremental phases of iodine fortification.

    Objective: To examine trends in thyroid-stimulating hormone (TSH) and thyroid peroxidase antibody (ATPO) testing and their relationship to different phases of iodine nutrition in the Tasmanian population between 1995 and 2013. Read More

    Iodine Status and Iodised Salt Consumption in Portuguese School-Aged Children: The Iogeneration Study.
    Nutrients 2017 May 5;9(5). Epub 2017 May 5.
    Center for Health Technology and Services Research (CINTESIS), 4200-450 Porto, Portugal.
    The World Health Organization promotes salt iodisation to control iodine deficiency. In Portugal, the use of iodised salt in school canteens has been mandatory since 2013. The present study aimed to evaluate iodine status in school-aged children (6-12 years) and to monitor the use of iodised salt in school canteens. Read More

    Comparison of urinary iodine levels in women of childbearing age during and after pregnancy.
    Eur J Nutr 2017 Apr 29. Epub 2017 Apr 29.
    Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain.
    Purpose: Median urinary iodine concentration (UIC) is used to describe the iodine status of a population. However, the link between UIC and iodine intake may vary during pregnancy. The aim of this study was to compare UIC during and after pregnancy, adjusting for factors that affect iodine intake. Read More

    Urinary Iodine Concentrations in Cancer Patients
    Asian Pac J Cancer Prev 2017 03 1;18(3):819-821. Epub 2017 Mar 1.
    Department of General Surgery, Shahid Sadoughi Hospital, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Email:
    Background: It has been suggested that incidence of some cancers, especially examples in the breast and stomach may be influenced by the iodine intake. However, only few studies are available at present. Therefore, we have conducted the present assessment of iodine status in Iranian patients diagnosed with a malignancy. Read More

    Epigenetic modulators of thyroid cancer.
    Endocrinol Diabetes Nutr 2017 Jan 20;64(1):44-56. Epub 2017 Jan 20.
    Department of Endocrinology and Nutrition, Hospital Universitario Central de Asturias (HUCA), Oviedo, Asturias, Spain. Electronic address:
    There are some well known factors involved in the etiology of thyroid cancer, including iodine deficiency, radiation exposure at early ages, or some genetic changes. However, epigenetic modulators that may contribute to development of these tumors and be helpful to for both their diagnosis and treatment have recently been discovered. The currently known changes in DNA methylation, histone modifications, and non-coding RNAs in each type of thyroid carcinoma are reviewed here. Read More

    Assessing the status of iodine deficiency disorder (IDD) and associated factors in Wolaita and Dawro Zones School Adolescents, southern Ethiopia.
    BMC Res Notes 2017 Apr 18;10(1):156. Epub 2017 Apr 18.
    College of Health Science and Medicine Wollo University, Dessie, Ethiopia.
    Background: Iodine deficiency is the major preventable cause of irreversible mental retardation in the world. Ethiopia is a country with high prevalence of iodine deficiency disorders which continue to affect a large number of the country's population. The aim of the study was to assess the prevalence of iodine deficiency disorder in Wolaita and Dawuro zones. Read More

    Household Coverage with Adequately Iodized Salt Varies Greatly between Countries and by Residence Type and Socioeconomic Status within Countries: Results from 10 National Coverage Surveys.
    J Nutr 2017 May 12;147(5):1004S-1014S. Epub 2017 Apr 12.
    Global Alliance for Improved Nutrition, Geneva, Switzerland.
    Background: Household coverage with iodized salt was assessed in 10 countries that implemented Universal Salt Iodization (USI).Objective: The objective of this paper was to summarize household coverage data for iodized salt, including the relation between coverage and residence type and socioeconomic status (SES).Methods: A review was conducted of results from cross-sectional multistage household cluster surveys with the use of stratified probability proportional to size design in Bangladesh, Ethiopia, Ghana, India, Indonesia, Niger, the Philippines, Senegal, Tanzania, and Uganda. Read More

    Variation in the mineral element concentration of Moringa oleifera Lam. and M. stenopetala (Bak. f.) Cuf.: Role in human nutrition.
    PLoS One 2017 7;12(4):e0175503. Epub 2017 Apr 7.
    School of Biosciences, University of Nottingham, Sutton Bonington, Loughborough, United Kingdom.
    Background: Moringa oleifera (MO) and M. stenopetala (MS) (family Moringaceae; order Brassicales) are multipurpose tree/shrub species. They thrive under marginal environmental conditions and produce nutritious edible parts. Read More

    Eliminating Iodine Deficiency in China: Achievements, Challenges and Global Implications.
    Nutrients 2017 Apr 5;9(4). Epub 2017 Apr 5.
    Parasitic and Endemic Disease Prevention and Control Division of the National Health and Family Planning Commission of China, 14 Zhichun Road, Beijing 100088, China.
    The prevention of iodine deficiency through salt iodization has been recognized as a global success story, and China stands at the forefront of this achievement with one of the most successful programs in the world. High level political commitment, national mandatory legislation, a state-managed edible salt industry and a complex and highly sophisticated surveillance system have facilitated the success of the program. Challenges have arisen however, including: (i) concern that adequate iodine status in pregnant women cannot be achieved without causing above adequate iodine intakes in children; (ii) declining iodine intake as a result of reductions in salt consumption and increased consumption of processed foods, which may not be made with iodized salt; (iii) the existence of areas with high iodine content in the water; and (iv) declines in household use of iodized salt due to concerns about excess iodine intake and thyroid disease. Read More

    Environmental Issues in Thyroid Diseases.
    Front Endocrinol (Lausanne) 2017 20;8:50. Epub 2017 Mar 20.
    Department of Clinical and Experimental Medicine, University of Messina School of Medicine, Messina, Italy; Master Program of Childhood, Adolescence and Women's Endocrine Health, University of Messina School of Medicine, Messina, Italy; Interdepartmental Program of Molecular & Clinical Endocrinology, and Women's Endocrine Health, University Hospital, Policlinico G. Martino, Messina, Italy.
    Environmental factors are determinant for the appearance of autoimmune thyroid diseases (AITD) in susceptible subjects. Increased iodine intake, selenium, and vitamin D deficiency, exposure to radiation, from nuclear fallout or due to medical radiation, are environmental factors increasing AITD. Cigarette smoking is associated with Graves' disease and Graves' ophthalmopathy, while it decreases the risk of hypothyroidism and thyroid autoimmunity. Read More

    Role of the Iodine Global Network in Elimination of Iodine Deficiency.
    Recent Pat Endocr Metab Immune Drug Discov 2017 Mar 30. Epub 2017 Mar 30.
    Emeritus Profesor of Clinical Endocrinology Cardiff School of Medicine Centre for Endocrine and Diabetes Sciences, University Hospital of Wales, United Kingdom.
    Background Iodine deficiency (ID) is a major cause of brain damage if not corrected in early pregnancy. Even mild ID leads to measurable neurointellectual impairment. The iodine global network (IGN), previously the international council for the control of iodine deficiency disorders (ICCIDD), has achieved remarkable progress in facilitating iodine nutritional sufficiency in about 70-80% of countries in the world during the past 3 decades or so. Read More

    Testing the tools for revealing and characterizing the iodine-iodine halogen bond in crystals.
    Acta Crystallogr B Struct Sci Cryst Eng Mater 2017 Apr 29;73(Pt 2):217-226. Epub 2017 Mar 29.
    Quantum Chemistry, Mendeleev University of Chemical Technology of Russia, 9, Miusskaya Square, Moscow 125047, Russian Federation.
    To understand what tools are really suitable to identify and classify the iodine-iodine non-covalent interactions in solid organic polyiodides, we have examined the anisotropy of the electron density within the iodine atomic basin along and across the iodine-iodine halogen bond using the Laplacian of electron density, one-electron potential and electron localization function produced by Kohn-Sham calculations with periodic boundary conditions. The Laplacian of electron density exhibits the smallest anisotropy and yields a vague picture of the outermost electronic shells. The one-electron potential does not show such a deficiency and reveals that the valence electron shell for the halogen-bond acceptor iodine is always wider than that for the halogen-bond donor iodine along its σ-hole direction. Read More

    Iodine Storage and Metabolism of Mild to Moderate Iodine-Deficient Pregnant Rats.
    Thyroid 2017 Jun 22;27(6):846-851. Epub 2017 May 22.
    1 Department of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Affiliated Hospital of China Medical University , Shenyang, People's Republic of China .
    Background: Severe iodine deficiency during pregnancy results in neurodevelopmental disorders in children, while the consequences of mild to moderate iodine deficiency (MMID) are uncertain. The concentration of iodine in the thyroid is the most accurate indicator of iodine nutrition. This study aimed to evaluate whether the iodine stores in the thyroid cover the needs of the mother and the fetus in iodine-sufficient and MMID conditions by inductively coupled plasma-mass spectrometry. Read More

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