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    Continuously sustained elimination of iodine deficiency: a quarter of a century success in the Islamic Republic of Iran.
    J Endocrinol Invest 2018 Feb 14. Epub 2018 Feb 14.
    Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Islamic Republic of Iran.
    Background: Iodine deficiency and related disorders were very common in Iran prior to 1996, when universal salt iodization (USI) was implemented and in 2000 Iran was declared iodine deficiency disorders (IDD) free. The aim of this study was to evaluate the adequacy of iodine intake by Iranian households in all 30 provinces of Iran, a quarter of a century after the intervention.

    Methods: A total of 18,000 school-aged children (8-10 years with mean 8. Read More

    Interaction between iodine and glucosinolates in rutabaga sprouts and selected biomarkers of thyroid function in male rats.
    J Trace Elem Med Biol 2018 Mar 15;46:110-116. Epub 2017 Dec 15.
    Department of Food Chemistry and Nutrition, Medical College, Jagiellonian University, Kraków, Poland. Electronic address:
    Rutabaga sprouts belong to the Brassicaceae family and may exert a negative influence on thyroid function, because they are a rich in glucosinolates. These sprouts are also valuable source of iodine (6.5 ± 0. Read More

    Breast milk is conditionally perfect.
    Med Hypotheses 2018 Feb 14;111:82-89. Epub 2017 Dec 14.
    Department of Nutrition, Brigham and Women's Hospital, Boston, MA 02115, USA. Electronic address:
    Breast milk is the universal preferred nutrition for the newborn human infant. New mother have been encouraged to exclusively breastfeed by health care professionals and consumer-advocacy forums for years, citing "breast milk is the perfect food". The benefits are numerous and include psychological, convenience, economical, ecological and nutritionally superior. Read More

    Med Princ Pract 2018 Jan 25. Epub 2018 Jan 25.
    To evaluate the thiol/disulphide homeostasis in children with non-autoimmune subclinical hypothyroidism.
    Materials (Subjects) and Methods
    Thiol-disulphide homeostasis [native thiol-disulphide exchanges (native thiol (SH), disulphide (SS), and total thiol (SS+SH))] was evaluated in 60 children and adolescents who were negative for thyroid auto-antibodies (anti-thyroid peroxidase, anti-thyroglobulin) and had a TSH value higher than 5 mIU/L and in 40 sex- and age-matched healthy control subjects who were negative for thyroid auto-antibodies and had normal TSH levels. Lipid profiles and urine iodine levels of the cases were determined. Read More

    [Recent Trends of Trace Element Studies in Clinical Medicine in Japan].
    Nihon Eiseigaku Zasshi 2018 ;73(1):75-82
    Department of Health and Dietetics, Faculty of Health and Medical Sciences, Teikyo Heisei University.
    The deficiency or excess intake of trace elements, including zinc, copper, selenium and iodine, has often been reported. Zinc deficiency is often observed in infants fed breast milk with low zinc concentration, individuals administered chelating medicines, athletes and patients with diabetes mellitus, hepatic cirrhosis or nephrosis syndrome. Menkes disease is associated with severe copper deficiency, and there is no effective treatment. Read More

    Biomonitoring Equivalents for interpretation of urinary iodine.
    Regul Toxicol Pharmacol 2018 Jan 27;94:40-46. Epub 2018 Jan 27.
    Health Canada, Ottawa, ON, Canada.
    Iodine is an essential nutrient whose deficiency or excess exposure can cause adverse health effects. The primary sources of iodine exposure in the general population are iodized salt, dairy products, bread and sea food. Urinary iodine concentrations (UIC) have been measured by Canadian Health Measures Survey (CHMS) and US National Health and Nutrition Examination Survey (NHANES). Read More

    The bioaccessibility of iodine in the biofortified vegetables throughout cooking and simulated digestion.
    J Food Sci Technol 2018 Jan 27;55(1):366-375. Epub 2017 Nov 27.
    1Institute of Environment and Biogeochemistry, Zhejiang University, Hangzhou, 310027 China.
    Biofortification of crops with exogenous iodine is a novel strategy to control iodine deficiency disorders (IDD). The bioaccessibility of iodine (BI) in the biofortified vegetables in the course of soaking, cooking and digestion, were examined. Under hydroponics, the concentration of iodine in leafstalks of the celery and pakchoi increased with increasing exogenous iodine concentration, 54. Read More

    Disorders of metal metabolism.
    Transl Sci Rare Dis 2017 Dec 18;2(3-4):101-139. Epub 2017 Dec 18.
    Section on Human Biochemical Genetics, Medical Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, MD, USA.
    Trace elements are chemical elements needed in minute amounts for normal physiology. Some of the physiologically relevant trace elements include iodine, copper, iron, manganese, zinc, selenium, cobalt and molybdenum. Of these, some are metals, and in particular, transition metals. Read More

    Primordial and Primary Preventions of Thyroid Disease.
    Int J Endocrinol Metab 2017 Oct 7;15(4):e57871. Epub 2017 Oct 7.
    Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran.
    Background: Primordial and primary preventions of thyroid diseases are concerned with avoiding the appearance of risk factors, delaying the progression to overt disease, and minimizing the impact of illness.

    Summary: Using related key words, 446 articles related to primordial and primary, preventions of thyroid diseases published between 2001-2015 were evaluated, categorized and analyzed. Prevention and elimination of iodine deficiency are major steps that have been successfully achieved and maintained in many countries of the world in last 2 decades. Read More

    Development of Databases on Iodine in Foods and Dietary Supplements.
    Nutrients 2018 Jan 17;10(1). Epub 2018 Jan 17.
    Nutrient Data Laboratory, US Department of Agriculture, Beltsville, MD 20705, USA.
    Iodine is an essential micronutrient required for normal growth and neurodevelopment; thus, an adequate intake of iodine is particularly important for pregnant and lactating women, and throughout childhood. Low levels of iodine in the soil and groundwater are common in many parts of the world, often leading to diets that are low in iodine. Widespread salt iodization has eradicated severe iodine deficiency, but mild-to-moderate deficiency is still prevalent even in many developed countries. Read More

    Reference intervals for thyrotropin in an area of Northern Italy: the Pordenone thyroid study (TRIPP).
    J Endocrinol Invest 2018 Jan 16. Epub 2018 Jan 16.
    Endocrinology and Autoimmunity Laboratory, Department of Internal Medicine, IRCCS Azienda Ospedaliera Universitaria San Martino-IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy.
    Purpose: Thyrotropin (TSH) is the most accurate marker of thyroid dysfunction in the absence of pituitary or hypothalamic disease. Studies on TSH reference intervals (RIs) showed wide inter-individual variability and prompted an intense debate about the best estimation of TSH RIs.

    Design: We performed a population study on TSH RIs, using current data stored in the laboratory information system (LIS), at the Hospital Department of Laboratory Medicine, Pordenone (Italy), historically an area of mild-moderate iodine deficiency with a relatively high goiter prevalence. Read More

    Delayed conception in women with low-urinary iodine concentrations: a population-based prospective cohort study.
    Hum Reprod 2018 Jan 11. Epub 2018 Jan 11.
    Biostatistics and Bioinformatics Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, 6710B building, Bethesda, MD 20892, USA.
    Study Question: Is iodine deficiency associated with decreased fecundability?

    Summary Answer: Moderate to severe iodine deficiency is associated with a 46% decrease in fecundability.

    What Is Known Already: Iodine deficiency is common in women of childbearing age but its effect on fecundability has not been investigated.

    Study Design, Size, Duration: The LIFE Study, a population-based prospective cohort study, enrolled 501 women who had discontinued contraception within 2 months to become pregnant between 2005 and 2009. Read More

    Effects of Maternal Marginal Iodine Deficiency on Interactions between Cerebellar Bergmann Glia Cells and Purkinje Cells in Rat Offspring.
    Biomed Environ Sci 2017 Dec;30(12):932-937
    Department of Occupational and Environmental Health, School of Public Health, China Medical University, Shenyang 110112, Liaoning, China.
    Iodine deficiency (ID) during early pregnancy has an adverse effect on children's psychomotor and motor function but the mechanism has not been clarified. Therefore, our aim was to study the effect of maternal marginal ID on cerebellar neurodevelopment and the underlying mechanism. After obtaining marginal ID rats, we examined interactions between Bergmann glia cells (BGs) and Purkinje cells (PCs) using immunofluorescence and expression of the glutamate transporter and receptor by western blot. Read More

    Breast-Milk Iodine Concentrations and Iodine Levels of Infants According to the Iodine Status of the Country of Residence: A Systematic Review and Meta-Analysis.
    Thyroid 2018 Jan;28(1):124-138
    4 Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences , Tehran, Iran .
    Background: Iodine, an essential micronutrient, plays a critical role in normal growth and development, especially during the first two years of life. This systematic review and meta-analysis is among the first to evaluate breast-milk iodine concentrations and infant iodine status in countries characterized by iodine sufficiency or deficiency.

    Methods: PubMed, Web of Science, Cochrane Library, Google Scholar, and other relevant databases, as well as reference lists of previous reviews, were searched for relevant studies published between 1986 and 2016. Read More

    Less than total thyroidectomy for goiter: when and how?
    Gland Surg 2017 Dec;6(Suppl 1):S49-S58
    Division of Endocrine Surgery, Department of General Surgery, Ege University Hospital, Izmir, Turkey.
    Benign goiter is the most common endocrine disease that requires surgery, especially in endemic areas suffering from iodine-deficiency. Recent European and American guidelines recommended total thyroidectomy for the surgical treatment of multinodular goiter. Total thyroidectomy has now become the technique of choice and is widely considered the most reliable approach in preventing recurrence. Read More

    Veganism as a cause of iodine deficient hypothyroidism.
    J Pediatr Endocrinol Metab 2018 Jan;31(1):91-94
    Pediatric Endocrinology, Goryeb Children's Hospital, Atlantic Health System, 100 Madison Ave., Morristown, NJ 07962, USA.
    Background: Iodine deficiency is the most common cause of acquired hypothyroidism worldwide. Although uncommon in the Western world, the incidence of iodine deficiency may be rising due to the increased use of restrictive diets.

    Case Presentation: We present a 23-month-old boy diagnosed with iodine deficiency hypothyroidism, induced by a vegan diet. Read More

    Past, present, and future of iodine deficiency disorders in India: Need to look outside the blinkers.
    J Family Med Prim Care 2017 Apr-Jun;6(2):182-190
    Department of Community Dentistry, Maulana Azad Institute of Dental Sciences, New Delhi, India.
    Iodine deficiency disorders (IDDs) have been recognized as one of the major nutritional disorders throughout the world affecting 200 million people who are at risk and another 71 million suffering from goiter and other IDDs. These groups of disorders can affect every stage of life, but most vulnerable age group is between 6 and 12 years and these disorders together constitute the single largest preventable cause of brain damage leading to learning disabilities and psychomotor impairment. The existence of endemic goiter in an extensive belt along the southern slopes of the Himalayas, Alps, and Andes has long been described, but consistently high prevalence of IDDs outside the endemic zones and failure to attain goals set by the National Iodine Deficiency Disorder Control Program questions the strategy and achievements till date. Read More

    Endemic goiter and iodine deficiency status among Guinea-Bissau school-age children.
    Eur J Clin Nutr 2017 Dec 28. Epub 2017 Dec 28.
    Laboratory of Hydrobiology and Ecology, Institute of Biomedical Sciences (ICBAS-UP) & CIIMAR, University of Porto, Porto, Portugal.
    Background/objectives: Iodine deficiency disorders are estimated to affect 25% of all school-age children around the world. Current policies concerning iodine deficiency disorders in many countries are not based on robust or recent national data. Our objective was to evaluate the current status of iodine nutrition in Guinea-Bissau (West Africa). Read More

    Iodine intake from supplements and diet during pregnancy and child cognitive and motor development: the INMA Mother and Child Cohort Study.
    J Epidemiol Community Health 2018 Mar 26;72(3):216-222. Epub 2017 Dec 26.
    CIBER Epidemiología y Salud Pública (CIBERESP), Spain.
    Background: The effect of mild-to-moderate maternal iodine deficiency on the neuropsychological development of their offspring is uncertain. We aimed to assess the association between iodine status during pregnancy and the cognitive and motor development of children at 4-5 years.

    Methods: We conducted a prospective cohort study in four Spanish regions with recruitment of pregnant women between 2003 and 2008 and follow-up of their children up to 4-5 years (mean (SD)=4. Read More

    [From scientific research to health policy design: the experience of iodine deficiency elimination in Peru].
    Rev Peru Med Exp Salud Publica 2017 Jul-Sep;34(3):538-543
    Universidad Peruana Cayetano Heredia. Lima, Perú.
    Scientific research is an essential public health function, enabling recognition of problems that compromise health and facilitating solutions. Research is essential to formulate health policy at a national level. There has been significant but inconsistent overall progress, due to economic conditions in low- and middle-income countries. Read More

    Troubling disease syndrome in endangered live Patagonian huemul deer (Hippocamelus bisulcus) from the Protected Park Shoonem: unusually high prevalence of osteopathology.
    BMC Res Notes 2017 Dec 16;10(1):739. Epub 2017 Dec 16.
    Laboratorio de Teriogenología "Dr. Héctor H. Morello", Facultad de Ciencias Agrarias, Univ. Nac. Comahue, Cinco Saltos, DeerLab, 8400, Bariloche, Argentina.
    Objective: The last 1500 endangered Patagonian huemul deer (Hippocamelus bisulcus) exist in > 100 groups which are not recovering. Prevalence of osteopathology in dead huemul was 57+% (Argentina), whereas similar cases in Chile were accompanied by selenium deficiency. The first clinical cases from live wild huemul confirm widespread osteopathology which explains short life spans, low recruitment, and thus absence of population recovery. Read More

    Reduced Educational Outcomes Persist into Adolescence Following Mild Iodine Deficiency in Utero, Despite Adequacy in Childhood: 15-Year Follow-Up of the Gestational Iodine Cohort Investigating Auditory Processing Speed and Working Memory.
    Nutrients 2017 Dec 13;9(12). Epub 2017 Dec 13.
    Faculty of Education, University of Tasmania, Locked Bag 1307, Launceston, TAS 7250, Australia.
    There is increasing evidence that even mild gestational iodine deficiency (GID) results in adverse neurocognitive impacts on offspring. It's unclear, however, if these persist long-term and whether they can be ameliorated by iodine sufficiency in childhood. We followed a unique cohort (Gestational Iodine Cohort,= 266) where gestation occurred during a period of mild population iodine deficiency, with children subsequently growing-up in an iodine replete environment. Read More

    Assessment of a Salt Reduction Intervention on Adult Population Salt Intake in Fiji.
    Nutrients 2017 Dec 12;9(12). Epub 2017 Dec 12.
    The George Institute for Global Health, University of New South Wales, Sydney NSW 2052, Australia.
    Reducing population salt intake is a global public health priority due to the potential to save lives and reduce the burden on the healthcare system through decreased blood pressure. This implementation science research project set out to measure salt consumption patterns and to assess the impact of a complex, multi-faceted intervention to reduce population salt intake in Fiji between 2012 and 2016. The intervention combined initiatives to engage food businesses to reduce salt in foods and meals with targeted consumer behavior change programs. Read More

    Biochemical iodine deficiency in selected schools of aligarh.
    Indian J Public Health 2017 Oct-Dec;61(4):309-311
    Professor, Department of Community Medicine, JN Medical College, AMU, Aligarh, Uttar Pradesh, India.
    The goiter prevalence reflects the iodine deficiency in past while urinary iodine excretion levels (UIEL) gives the current status of iodine nutrition. The study was conducted to assess the status of biochemical iodine deficiency in school children of 1st-5th standard (6-12 years). A total of 907 students of seven schools were included using probability proportional to size method. Read More

    Supplementation during pregnancy with small-quantity lipid-based nutrient supplements or multiple micronutrients, compared with iron and folic acid, increases women's urinary iodine concentration in semiurban Ghana: A randomized controlled trial.
    Matern Child Nutr 2017 Dec 6. Epub 2017 Dec 6.
    Program in International and Community Nutrition, Department of Nutrition, University of California, Davis, California, USA.
    There is little information on whether prenatal multiple micronutrient (MMN) supplements containing iodine affect women's iodine status. In the International Lipid-based Nutrient Supplements DYAD-Ghana trial, we aimed to assess women's urinary iodine concentration (UIC, μg/L) during pregnancy, as one of the planned secondary outcomes. Women (n = 1,320) <20 weeks of gestation were randomized to consume 60 mg iron and 400 μg folic acid per day (iron and folic acid [IFA]); 18 vitamins and minerals including 250 μg iodine per day (MMN); or 20 g/day of small-quantity lipid-based nutrient supplements (LNS) with the same and additional 4 vitamins and minerals as the MMN (LNS). Read More

    Worldwide Recall Rate in Newborn Screening Programs for Congenital Hypothyroidism.
    Int J Endocrinol Metab 2017 Jul 25;15(3):e55451. Epub 2017 Jun 25.
    Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran.
    Context: Neonatal mass screening program for congenital hypothyroidism provides the best tool for prevention of its devastating effects on mental development. Despite the overall success of the screening programs in detecting congenital hypothyroidism and eliminating its sequelae and new developments made in the program design, high recall rate and false positive results impose a great challenge worldwide. Lower recall rate and false positive results may properly organize project expenses by reducing the unnecessary repeated laboratory tests, increase physicians and parents' assurance and cooperation, as well as reduce the psychological effects in families. Read More

    Urinary iodine concentration and thyroid hormones: Korea National Health and Nutrition Examination Survey 2013-2015.
    Eur J Nutr 2017 Nov 29. Epub 2017 Nov 29.
    Division of Endocrinology and Metabolism, Department of Medicine, Thyroid Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 06351, South Korea.
    Purpose: An epidemiologic study that evaluated population's iodine nutrition status and its relationship with thyroid hormones is lacking in iodine-sufficient area. This nationwide study aimed to evaluate the iodine nutrition status in Korea and relationship between urine iodine concentration (UIC) and thyroid hormones.

    Methods: A total of 8318 subjects of the Korea National Health and Nutrition Examination Survey VI (2013-2015) with UIC and thyroid hormone evaluation were included. Read More

    A Role for Iodide and Thyroglobulin in Modulating the Function of Human Immune Cells.
    Front Immunol 2017 15;8:1573. Epub 2017 Nov 15.
    Clinical Immunology Laboratory, Rosalind Franklin University of Medicine and Science, North Chicago, IL, United States.
    Iodine is an essential element required for the function of all organ systems. Although the importance of iodine in thyroid hormone synthesis and reproduction is well known, its direct effects on the immune system are elusive. Human leukocytes expressed mRNA of iodide transporters (NIS and PENDRIN) and thyroid-related proteins [thyroglobulin (TG) and thyroid peroxidase (TPO)]. Read More

    Transient hypothyroidism in the newborn: to treat or not to treat.
    Transl Pediatr 2017 Oct;6(4):349-358
    Department of Pediatrics, Division of Neonatal-Perinatal Medicine, MetroHealth Medical Center, Case Western Reserve University, Cleveland, Ohio, USA.
    Transient congenital hypothyroidism (CH) refers to a temporary deficiency of thyroid hormone identified after birth, with low thyroxine (T4) and elevated thyrotropin (TSH), which later recovers to improved thyroxine production, typically in first few months of infancy. Approximately 17% to 40% of children diagnosed with CH by newborn screening (NBS) programs were later determined to have transient hypothyroidism. Causes of transient CH are prematurity, iodine deficiency, maternal thyrotropin receptor blocking antibodies, maternal intake of anti-thyroid drugs, maternal or neonatal iodine exposure, loss of function mutations and hepatic hemangiomas. Read More

    Insulin Resistance: Any Role in the Changing Epidemiology of Thyroid Cancer?
    Front Endocrinol (Lausanne) 2017 14;8:314. Epub 2017 Nov 14.
    Endocrinology, Department of Health Sciences, University Magna Graecia of Catanzaro, Catanzaro, Italy.
    In the past few decades, the incidence of thyroid cancer (TC), namely of its papillary hystotype (PTC), has shown a steady increase worldwide, which has been attributed at least in part to the increasing diagnosis of early stage tumors. However, some evidence suggests that environmental and lifestyle factors can also play a role. Among the potential risk factors involved in the changing epidemiology of TC, particular attention has been drawn to insulin-resistance and related metabolic disorders, such as obesity, type 2 diabetes, and metabolic syndrome, which have been also rapidly increasing worldwide due to widespread dietary and lifestyle changes. Read More

    Status of Iodine Nutrition among Pregnant Women Attending Antenatal Clinic of a Secondary Care Hospital: A Cross-sectional Study from Northern India.
    Indian J Community Med 2017 Oct-Dec;42(4):226-229
    Centre for Community Medicine, All India Institute of Medical Sciences, New Delhi, India.
    Background: Daily requirement of iodine increases during pregnancy making pregnant women a high-risk group for iodine deficiency disorders. The limited available literature shows that even in iodine sufficient population, pregnant women are iodine deficient.

    Objective: The objective of this study is to assess the current iodine nutrition status among pregnant women in Ballabgarh, district Faridabad, Haryana. Read More

    Prevalence of goiter and associated factors among schoolchildren in northeast Ethiopia.
    Epidemiol Health 2017 25;39:e2017055. Epub 2017 Nov 25.
    Department of Epidemiology and Biostatistics, Institute of Public Health, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
    Objectives: Goiter is a major public health problem, especially in developing countries such as Ethiopia. Hence, this study aimed to assess the prevalence and associated factors of goiter among children in Waghimra Zone, northeast Ethiopia.

    Methods: A cross-sectional study was conducted from April 8 to 25, 2015 in northeast Ethiopia. Read More

    High Urinary Iodine, Thyroid Autoantibodies, and Thyroid-Stimulating Hormone for Papillary Thyroid Cancer Risk.
    Biol Trace Elem Res 2017 Nov 21. Epub 2017 Nov 21.
    Department of Breast and Thyroid Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
    Thyroid nodules have become a common clinical problem, and the clinical importance of thyroid nodules lies in the determination of thyroid cancer. This study aims to evaluate the risk factors for papillary thyroid cancer (PTC) with regard to urinary iodine concentration (UIC), thyroid-stimulating hormone (TSH), thyroid peroxidase antibody (TPOAb), and thyroglobulin antibody (TGAb) in comparison to thyroid nodular goiter (NG). Among the 2041 patients, 43. Read More

    Maternal iodine status during lactation and infant weight and length in Henan Province, China.
    BMC Pregnancy Childbirth 2017 Nov 16;17(1):383. Epub 2017 Nov 16.
    Department for Endemic Disease Control and Prevention, Center for Disease Control of Henan Province, Room 4201, No. 105 Nongye Nan Road, Zhengdong New District, Zhengzhou, 450016, China.
    Background: Infants are very sensitive to iodine deficiency. Breastfed infants are dependent on maternal iodine intake. The aim of this study was to evaluate the relationship between maternal iodine status during lactation and infant weight and length. Read More

    Moderate iodine deficiency among pregnant women in Hong Kong: revisit the problem after two decades.
    Hong Kong Med J 2017 Dec 10;23(6):586-93. Epub 2017 Nov 10.
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong.
    Introduction: A survey conducted during 2005 to 2007 by the Centre for Food Safety in Hong Kong suggested that only 5% of the local population had a sufficient dietary intake of iodine. The study, however, was limited as biochemical data (ie urinary iodine concentration) were lacking. Pregnant women are vulnerable to iodine deficiency because of their increased requirement. Read More

    [Thyroid disease in the Czech Republic: the EUthyroid project and the evaluation of the General Health Insurance Company epidemiological data for the period of 2012-2015].
    Vnitr Lek Fall 2017;63(9):548-554
    Institute of Endocrinology participates in the grant of European Commission EUthyroid (Towards the elimination of iodine deficiency and preventable thyroid-related diseases in Europe), together with other 28 European countries. The role of Institute of Endocrinology in EUthyroid is among other things to ensure access to national registers relating to thyroid diseases. The results presented here correspond to the years 2012-2015 and are based on data from the General Health Insurance Company Czech Republic (VZP CR), which has 6 million insured persons (ratio male : female = 1 : 1). Read More

    Iodine Status of Taiwanese Population in 2013: 10 Years After Changing From Mandatory to Voluntary Salt Iodization.
    Food Nutr Bull 2018 Mar 8;39(1):75-85. Epub 2017 Nov 8.
    2 National Yang-Ming University School of Medicine, Taipei, Taiwan.
    Background: In 2003, Taiwan's iodine policy changed from mandatory to voluntary. The Nutrition and Health Survey in Taiwan (NAHSIT) 2001-2002 for schoolchildren showed adequate iodine nutrition, while NAHSIT 2005-2008 for adults showed the iodine status was at borderline adequacy.

    Objective: To investigate the iodine status of the Taiwanese population from schoolchildren to adulthood 10 years after the change of the salt iodization policy. Read More

    Nutrients intake, and serum calcium and phosphorus levels: An evidence-based study.
    J Clin Lab Anal 2018 Feb 7;32(2). Epub 2017 Nov 7.
    Metabolic syndrome Research center, Mashhad University of Medical Sciences, Mashhad, Iran.
    Introduction: Dietary calcium and phosphorus appear to be important determinants of dyslipidemia and hypertension. We have investigated (1) the prevalence of hypocalcemia and hypophosphatemia in an Iranian population, and (2) the association between nutrient's intake and serum levels of calcium and phosphorus.

    Methods: A total of 908 individuals were enrolled using a stratified-cluster sampling method from the Mashhad stroke and heart atherosclerosis disorder (MASHHAD) study. Read More

    Iodized Salt Intake and Its Association with Urinary Iodine, Thyroid Peroxidase Antibodies, and Thyroglobulin Antibodies Among Urban Chinese.
    Thyroid 2017 Dec;27(12):1566-1573
    1 Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine , Shanghai, China .
    Background: Whether iodized salt increases the risk of thyroid disease has been strongly debated in China, especially in the urban areas of coastal regions, in recent years. This study aimed to investigate the status of iodized salt in terms of urinary and serum iodine concentration in urban coastal areas, and to explore further whether consumption of iodized salt or non-iodized salt is associated with autoimmune thyroid disease (AITD).

    Methods: The data source was SPECT-China, a cross-sectional study in East China. Read More

    A First Report of Secondary Hemophagocytic Lymphohistiocytosis Associated With Papillary Thyroid Carcinoma.
    J Pediatr Hematol Oncol 2018 Mar;40(2):e97-e98
    Division of Bone Marrow Transplantation and Immune Deficiency.
    Secondary hemophagocytic lymphohistiocytosis (HLH) is a rare and potentially fatal immune-deficiency disorder that develops in response to diseases that produce strong immunologic activation, such as infection and malignancy. Although secondary HLH is reported to occur in association with various malignancies, there is no report of its association with thyroid cancer. We evaluated a 19-year-old man who presented with HLH. Read More

    The Impact of Iodine Status on the Recall Rate of the Screening Program for Congenital Hypothyroidism: Findings from Two National Studies in Iran.
    Nutrients 2017 Oct 30;9(11). Epub 2017 Oct 30.
    Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, 1985717413, Tehran, Iran.
    Back ground: Iodine deficiency is one of the important factors in increasing the recall rate in congenital hypothyroidism (CH) screening programs. The present study assessed whether the iodine status of the general population may predict the recall rate or vice versa.

    Methods: In the current national study, among 1,382,229 live births delivered between March 2010 and March 2011, 1,288,237 neonates were screened for detecting CH by TSH (thyroid stimulating hormone) measurement via heel prick sampling. Read More

    Dietary Iodine Exposure and Brain Structures and Cognition in Older People. Exploratory Analysis in the Lothian Birth Cohort 1936.
    J Nutr Health Aging 2017 ;21(9):971-979
    Dr. Maria C. Valdés Hernández, Department of Neuroimaging Sciences, Centre for Clinical Brain Sciences, University of Edinburgh, 49 Little France Crescent, Chancellor's Building, Edinburgh, EH16 4SB, UK. Telephone:+44-131-4659527, Fax: +44-131-3325150, E-mail:
    Background: Iodine deficiency is one of the three key micronutrient deficiencies highlighted as major public health issues by the World Health Organisation. Iodine deficiency is known to cause brain structural alterations likely to affect cognition. However, it is not known whether or how different (lifelong) levels of exposure to dietary iodine influences brain health and cognitive functions. Read More

    Effect of broccoli sprouts on thyroid function, haematological, biochemical, and immunological parameters in rats with thyroid imbalance.
    Biomed Pharmacother 2018 Jan 6;97:82-90. Epub 2017 Nov 6.
    Department of Food Chemistry and Nutrition, Medical College, Jagiellonian University, Medyczna 9, 30-688 Kraków, Poland.
    Broccoli sprouts may exert a negative influence on thyroid function as they are a rich source of glucosinolates, in particular glucoraphanin. Under the study in a long-term experiment broccoli sprouts were tested as an element of rats diet, combined with deficient iodine, or sulfadimethoxine ingestion - two models of hypothyroidism. Evaluations were performed for serum TSH and thyroid hormones completed with analyzes of selected haematological, biochemical and immunological (IL-6, IL-10) parameters, as well as cytosolic glutathione peroxidase (GPX1), thioredoxin reductase (TR) in the thyroid, and plasma glutathione peroxidase (GPX3). Read More

    [Caries prevention with fluoridated and iodinated salt in school-aged children living in areas with fluoride and iodine deficiency].
    Stomatologiia (Mosk) 2017;96(5):66-68
    Azerbaijan Medical Academy, Baku, Azerbaijan.
    The aim of the study was to evaluate the efficacy of dental caries prevention program with 3 years follow-up in children living in areas with fluoride and iodine deficiency. The study involved 625 school-aged children aged 6, 12 and 15 years receiving endogenous prevention with fluoridated and iodinated salt (300±50 mgF/kg and 40±10 mgI/kg). Enamel and dentine concentrations of CA, P, F and I were measured in 98 intact deciduous teeth by X-ray microanalysis before and after prevention program. Read More

    Interrelationship between iodine nutritional status of lactating mothers and their absolutely breast-fed infants in coastal districts of Gangetic West Bengal in India.
    Eur J Pediatr 2018 Jan 23;177(1):39-45. Epub 2017 Oct 23.
    Endocrinology and Reproductive Physiology Laboratory, Department of Physiology, University of Calcutta, University College of Science and Technology, 92, APC Road, Kolkata, West Bengal, 700 009, India.
    Iodine nutritional status of 128 lactating mothers and their breast-fed infants (1-3 months) from iodine-replete villages during post-salt iodization period was evaluated. Mothers' urine, blood, and breast milk (BM) and infants' urine and blood were collected and analyzed for iodine and serum FTand TSH estimation. Mothers' and infants' age, parity, occupation, education, and household income were recorded. Read More

    Phagocytosis Deficiency of Macrophages in NOD.H-2Mice Accelerates the Severity of Iodine-Induced Autoimmune Thyroiditis.
    Biol Trace Elem Res 2017 Oct 20. Epub 2017 Oct 20.
    Department of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, First Affiliated Hospital of China Medical University, No. 155 Nanjing North Street, Shenyang, Liaoning, 110001, China.
    Apoptosis occurs in many autoimmune diseases. Excess iodine induces thyrocyte apoptosis and increases the incidence and prevalence of autoimmune thyroiditis (AIT). However, the sequence of events between the appearance of thyrocyte apoptosis and the occurrence of thyroiditis remains uncharacterized. Read More

    Iodine nutritional status in Asturian schoolchildren.
    Endocrinol Diabetes Nutr 2017 Nov 24;64(9):491-497. Epub 2017 Aug 24.
    Servicio Endocrinología y Nutrición, Hospital Universitario Central de Asturias, Oviedo, España.
    Introduction: Iodine deficiency is a public health problem, and iodine nutritional status should therefore be regularly measured.

    Objective: To ascertain iodine nutritional status in Asturias and its relation to use of iodized salt and to other sociodemographic and nutritional parameters.

    Material And Methods: A descriptive, observational study was conducted in a random sample of schoolchildren aged 5 to 14 years, in whom urinary iodine levels were measured by high-performance liquid chromatography. Read More

    Microbial Transformation of Iodine: From Radioisotopes to Iodine Deficiency.
    Adv Appl Microbiol 2017 7;101:83-136. Epub 2017 Sep 7.
    Texas A&M University, Galveston, TX, United States.
    Iodine is a biophilic element that is important for human health, both as an essential component of several thyroid hormones and, on the other hand, as a potential carcinogen in the form of radioiodine generated by anthropogenic nuclear activity. Iodine exists in multiple oxidation states (-1, 0, +1, +3, +5, and +7), primarily as molecular iodine (I), iodide (I), iodate [Formula: see text] , or organic iodine (org-I). The mobility of iodine in the environment is dependent on its speciation and a series of redox, complexation, sorption, precipitation, and microbial reactions. Read More

    Evaluation of serum ferritin and thyroid function in the second trimester of pregnancy.
    Endocr J 2018 Jan 13;65(1):75-82. Epub 2017 Oct 13.
    Department of Endocrinology, Fifth People's Hospital of Shanghai Fudan University, Shanghai, China.
    Ferritin is a universal intracellular protein that acts as an iron carrier. Several studies have indicated that iron deficiency affects thyroid function in non-pregnant women. Our objective was to assess the relationship between serum ferritin levels and thyroid function in pregnant women during the second trimester. Read More

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