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    Vitamin D deficiency affects thyroid autoimmunity and dysfunction in iodine-replete area: Korea national health and nutrition examination survey.
    Endocrine 2017 Sep 21. Epub 2017 Sep 21.
    Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, Korea.
    Purpose: We evaluated the effects of vitamin D levels and iodine intake on thyroid autoimmunity and dysfunction in the Korean population.

    Methods: In this nationwide population-based study, data were obtained from the Korea National Health and Nutrition Examination Survey VI-1 and 2 (2013 and 2014), which was the first nationwide survey that measured both serum 25-hydroxy vitamin D [25(OH)D] levels and urinary iodine concentrations (UICs) in Korea. A total of 4181 participants who underwent laboratory tests for thyroid function, serum 25(OH)D levels, and UICs were included. Read More

    Iodine Intake through Processed Food: Case Studies from Egypt, Indonesia, the Philippines, the Russian Federation and Ukraine, 2010-2015.
    Nutrients 2017 Jul 26;9(8). Epub 2017 Jul 26.
    Large Scale Food Fortification Initiative, Global Alliance for Improved Nutrition, 1202 Geneva, Switzerland.
    The current performance indicator for universal salt iodisation (USI) is the percentage of households using adequately iodised salt. However, the proportion of dietary salt from household salt is decreasing with the increase in consumption of processed foods and condiments globally. This paper reports on case studies supported by the Global Alliance for Improved Nutrition (GAIN)-UNICEF USI Partnership Project to investigate processed food industry use of adequately iodised salt in contrasting national contexts. Read More

    mHealth Application Areas and Technology Combinations*. A Comparison of Literature from High and Low/Middle Income Countries.
    Methods Inf Med 2017 Aug 8;56(7):e105-e122. Epub 2017 Aug 8.
    Haitham Abaza, Peter L. Reichertz Institute for Medical Informatics, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany, E-mail:
    Background: With the continuous and enormous spread of mobile technologies, mHealth has evolved as a new subfield of eHealth. While eHealth is broadly focused on information and communication technologies, mHealth seeks to explore more into mobile devices and wireless communication. Since mobile phone penetration has exceeded other infrastructure in low and middle-income countries (LMICs), mHealth is seen as a promising component to provide pervasive and patient-centered care. Read More

    Snack and beverage consumption and preferences in a sample of Chinese children - Are they influenced by advertising?
    Asia Pac J Clin Nutr 2017 ;26(6):1125-1132
    Sydney School of Public Health, the University of Sydney, Sydney, Australia.
    Background And Objectives: The consumption of unhealthy snack and beverages can lead to childhood obesity, which has become a major concern globally. Television food advertisements may influence children's snack and beverages preferences. This article aims to explore children's snack and beverage consumption habits; examine the extent of television advertising for non-core (energy-dense, nutrient poor) snack and beverages; and assess the influence of television advertising on children's snack and beverages preferences in Harbin, China. Read More

    A Paleolithic-type diet results in iodine deficiency: a 2-year randomized trial in postmenopausal obese women.
    Eur J Clin Nutr 2017 Sep 13. Epub 2017 Sep 13.
    Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden.
    Background/objectives: Different diets are used for weight loss. A Paleolithic-type diet (PD) has beneficial metabolic effects, but two of the largest iodine sources, table salt and dairy products, are excluded. The objectives of this study were to compare 24-h urinary iodine concentration (24-UIC) in subjects on PD with 24-UIC in subjects on a diet according to the Nordic Nutrition Recommendations (NNR) and to study if PD results in a higher risk of developing iodine deficiency (ID), than NNR diet. Read More

    The legislative framework for salt iodization in Asia and the Pacific and its impact on programme implementation.
    Public Health Nutr 2017 Sep 7:1-11. Epub 2017 Sep 7.
    4Evidence and Programme Guidance,Department of Nutrition for Health and Development,World Health Organization,Geneva,Switzerland.
    Objective: Fortification of food-grade (edible) salt with iodine is recommended as a safe, cost-effective and sustainable strategy for the prevention of iodine-deficiency disorders. The present paper examines the legislative framework for salt iodization in Asian countries.

    Design: We reviewed salt iodization legislation in thirty-six countries in Asia and the Pacific. Read More

    S Afr J Surg 2017 Sep;55(3):69
    University of Beira Interior, and Centro Hospitalar Cova da Beira, Hospital da Covilhã, and CICS-UBI Health Sciences Research Centre, Faculty of Health Sciences, University of Beira Interior.
    Background: Iodine deficiency (ID) still affects over two billion people worldwide (266 million school aged children). Pathology patterns in ID include: increase in thyroid cancer, higher percentages of follicular and anaplastic cancers and inversion of the papillary/follicular thyroid cancer frequency ratio. China succeeded in eliminating ID through legislation introduced in 1987 aimed at availability of iodized salt countrywide and South Africa through legislation introduced in 1995. Read More

    [Cytokine dysregulation in children with chronic catarrhal gingivitis living in polluted areas with fluoride and iodine deficiency].
    Stomatologiia (Mosk) 2017 ;96(4):48-51
    Lvov National Medical University named after Danila Galizkiy, Lvov, Ukraine.
    The aim of the research was to study the state of oral liquid immunity in children with chronic catarrhal gingivitis living in unfavorable environmental conditions. The study included 190 children with chronic catarrhal gingivitis (CCG): 110 children aged 7, 12 and 15 years and residing in ecologically unfavorable areas of Lviv region and 80 children living in 'conditionally clean' region which constituted comparison group. Children with CCG from polluted areas had increased content of pro-inflammatory cytokines and reduction of anti-inflammatory cytokines compared to controls. Read More

    Association of obesity and diabetes with thyroid nodules.
    Endocrine 2017 Aug 23. Epub 2017 Aug 23.
    Dipartimento Biomedico di Medicina Interna e Specialistica (DIBIMIS) - University of Palermo (Italy), Via del Vespro 129, 90127, Palermo, Italy.
    Aim: There are conflicting data concerning the possibility that obesity and diabetes raise the risk of thyroid nodules. The incidence of thyroid nodules is increasing, as is that of obesity and diabetes; therefore, understanding whether these metabolic and nutritional disorders influence nodular thyroid disease is important for organizing prevention strategies. This study investigated the association between thyroid nodules, obesity, diabetes, and dietary habits. Read More

    Evaluation of Bone Density, Serum Total and Ionized Calcium, Alkaline Phosphatase and 25-hydroxy Vitamin D in Papillary Thyroid Carcinoma, and their Relationship with TSH Suppression by Levothyroxine.
    Adv Biomed Res 2017 28;6:94. Epub 2017 Jul 28.
    Department of Biostatistics, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
    Background: This study aimed to evaluate the situation of Bone Mineral Density (BMD), Z score, T score, serum level of corrected and ionized calcium, alkaline phosphatase and 25-hydroxy vitamin D in percutaneous transhepatic cholangiography (PTC) patients and correlation of these variants with thyroid stimulating hormone (TSH) suppression level by levothyroxine.

    Materials And Methods: Among the patients referred to Esfahan's endocrinology research center, 34 PTC patients (aged 20-50 years) with a history of thyroidectomy and conceived radioactive iodine and suppressive dose of levothyroxine were evaluated in this case-control study, and 38 healthy persons participated as the control group (matched by age and sex, body mass index). Bone density was evaluated with the DEXA method in four areas: Lumbar spine, femoral neck, and trochanter and distal of forearm. Read More

    Iodine excess exposure during pregnancy and lactation impairs maternal thyroid function in rats.
    Endocr Connect 2017 Oct 16;6(7):510-521. Epub 2017 Aug 16.
    Department of Physiology and BiophysicsInstitute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil
    Adequate maternal iodine consumption during pregnancy and lactation guarantees normal thyroid hormones (TH) production, which is crucial to the development of the fetus. Indeed, iodine deficiency is clearly related to maternal hypothyroidism and deleterious effects in the fetal development. Conversely, the effects of iodine excess (IE) consumption on maternal thyroid function are still controversial. Read More

    Maternal hypothyroidism: An overview of current experimental models.
    Life Sci 2017 Oct 12;187:1-8. Epub 2017 Aug 12.
    Endocrine Physiology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address:
    Maternal hypothyroidism (MH) is the most common cause of transient congenital hypothyroidism. Different animal models are used for assessing developmental effects of MH in offspring. The severity and status of hypothyroidism in animal models must be a reflection of the actual conditions in humans. Read More

    Iodine-Rich Herbs and Potassium Iodate Have Different Effects on the Oxidative Stress and Differentiation of TH17 Cells in Iodine-Deficient NOD.H-2(h4) Mice.
    Biol Trace Elem Res 2017 Aug 12. Epub 2017 Aug 12.
    The First Clinical College, Liaoning University of Traditional Chinese Medicine (TCM), Chongshan East Road No.72, Shenyang, Liaoning, 110032, China.
    Iodine-rich herbs such as seaweed, kelp, and sea tangle were widely used to treat various types of goiter with good effect and without any adverse side effects in China. When compared with potassium iodate (PI), iodine-rich herbs had a positive effect on the recovery of goiter resulting from iodine deficiency without any obvious harmful effects. In NOD. Read More

    Iodine status among pregnant women in rural Sabah, Malaysia.
    Asia Pac J Clin Nutr 2017 ;26(5):861-866
    School of Health Sciences, Universiti Sains Malaysia, Kelantan, Malaysia.
    Background And Objectives: In 2000, legislation on mandatory universal salt iodisation was enacted in Sabah, Malaysia, to reduce the incidence of iodine deficiency disorders among its population. To evaluate the iodine levels among pregnant women from selected rural divisions in Sabah 13 years after the enactment of the universal salt iodisation programme.

    Methods And Study Design: This cross-sectional study was conducted from 1 May to 30 June, 2013, in three rural divisions of Sabah (the Interior, the West Coast, and Kudat). Read More

    Iodine status of postpartum women and their infants in Australia after the introduction of mandatory iodine fortification.
    Br J Nutr 2017 Jun;117(12):1656-1662
    1School of Agriculture, Food and Wine,Foodplus Research Centre,University of Adelaide,PMB 1, Glen Osmond, SA 5064,Australia.
    Mandatory I fortification in bread was introduced in Australia in 2009 in response to the re-emergence of biochemical I deficiency based on median urinary I concentration (UIC)<100 µg/l. Data on the I status of lactating mothers and their infants in Australia are scarce. The primary aim of this study was to assess the I status, determined by UIC and breast milk I concentration (BMIC), of breast-feeding mothers in South Australia and UIC of their infants. Read More

    Availability of adequately iodized in Northwest Ethiopia: a cross-sectional study.
    Arch Public Health 2017 31;75:33. Epub 2017 Jul 31.
    Department of Epidemiology and Biostatistics, Institute of Public Health, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
    Background: Universal salt iodization is the most cost-effective, safe and sustainable strategy to eliminate iodine deficiency disorders. However, little is known about the availability of adequately iodized salt in the northwestern part of Ethiopia. Thus, the aim of this study was to assess the availability of adequately iodized salt at the household level and associated factors in Dabat District, northwest Ethiopia. Read More

    Promoting Early Child Development With Interventions in Health and Nutrition: A Systematic Review.
    Pediatrics 2017 Aug;140(2)
    Centre for Global Child Health, The Hospital for Sick Children, Toronto, Ontario, Canada; and
    Context: Although effective health and nutrition interventions for reducing child mortality and morbidity exist, direct evidence of effects on cognitive, motor, and psychosocial development is lacking.

    Objective: To review existing evidence for health and nutrition interventions affecting direct measures of (and pathways to) early child development.

    Data Sources: Reviews and recent overviews of interventions across the continuum of care and component studies. Read More

    Effect of Iodine Nutrition on Pregnancy Outcomes in an Iodine-Sufficient Area in China.
    Biol Trace Elem Res 2017 Aug 2. Epub 2017 Aug 2.
    Department of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, First Affiliated Hospital of China Medical University, Shenyang, Liaoning Province, People's Republic of China.
    Many studies focused on the association between thyroid disease and pregnancy outcomes. The present study explored the effect of iodine nutrition during the first trimester on pregnancy outcomes. One thousand five hundred sixty-nine pregnant, euthyroid women at ≤12 weeks of gestation in an iodine-sufficient area in China were recruited. Read More

    Iodine Status After Bariatric Surgery-a Prospective 10-Year Report from the Swedish Obese Subjects (SOS) Study.
    Obes Surg 2017 Aug 2. Epub 2017 Aug 2.
    Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
    Context: Bariatric surgery can lead to nutrient deficiencies. Gastric by-pass (GBP) entails restriction and malabsorption, whereas, vertical banded gastroplasty (VBG) is only restrictive.

    Objective: The objective of this study is to study whether GBP-patients develop iodine deficiency from malabsorption, and if GBP- and VBG-patients develop lower 24-h urinary iodine excretion (24-UIE) than obese non-operated controls (OB-controls) due to lower iodine intake. Read More

    Assessing Selenium, Manganese, and Iodine Status in Pediatric Patients Receiving Parenteral Nutrition.
    Nutr Clin Pract 2017 Aug 14;32(4):552-556. Epub 2017 Mar 14.
    1 Department of Pharmacy, Primary Children's Hospital, Salt Lake City, Utah, USA.
    Background: Pediatric patients who are receiving parenteral nutrition (PN) unsupplemented with trace minerals can become deficient. Due to shortages in trace mineral products and the 2004 American Society for Parenteral and Enteral Nutrition report stating that individualized trace element supplementation may be warranted, a review was conducted concerning the trace minerals selenium (Se), manganese (Mn), and iodine (I).

    Method: A retrospective review of pediatric patients receiving PN that contained Se and Mn was conducted to determine if a difference existed between them and patients receiving PN without Se and Mn. Read More

    Double Fortified Salt Intervention Improved Iron Intake But Not Energy and Other Nutrient Intakes in Female Tea Plantation Workers From West Bengal, India.
    Food Nutr Bull 2017 Jan 1:379572117718121. Epub 2017 Jan 1.
    2 Division of Nutritional Sciences, Cornell University, Ithaca, NY, USA.
    Background: Iron deficiency is a global public health concern and has implications on the health status of women in reproductive age.

    Objective: We hypothesized that improving iron intake with double fortified salt would improve food intake, resulting in higher energy, nutrient intakes, and weight indicators of female tea plantation workers.

    Methods: In this randomized double-masked study, the participants (n = 245) were assigned to receive salt double fortified with iron and iodine (DFS; treatment) or salt fortified with iodine (control) and followed for 7. Read More

    Serum Thyroglobulin-A Sensitive Biomarker of Iodine Nutrition Status and Affected by Thyroid Abnormalities and Disease in Adult Populations.
    Biomed Environ Sci 2017 Jul;30(7):508-516
    Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University; Key Lab of Etiology and Epidemiology, National Health and Family Planning Commission (23618504), Harbin 150086, Heilongjiang, China.
    Objective: To evaluate the usefulness of the thyroglobulin (Tg) level in adults as a nutritional biomarker of iodine status and to identify the factors related to the serum Tg level.

    Methods: A cross-sectional study was conducted in adult populations of areas differing in iodine nutrition from three provinces (Autonomous Region) in China. Serum levels of thyroid hormones and Tg as well as thyroid autoantibodies were measured. Read More

    Re-establishment of normal radioactive iodine uptake reference range in the era of universal salt iodization in the Indian population.
    Indian J Med Res 2017 Mar;145(3):358-364
    Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi, India.
    Background & Objectives: The reference radioactive iodine uptake (RAIU) values established in the 1970s in the era of widespread iodine deficiency were relatively high. Now, after four decades of successful Universal Salt Iodization (USI) programme in India, there is a need to re-establish these reference ranges. The present study was aimed to quantify the two-hour and 24-h RAIU values in iodine sufficient euthyroid individuals and validate the results in Graves' and Hashimoto's thyroiditis patients. Read More

    Comparison of two sources of iodine delivery on breast milk iodine and maternal and infant urinary iodine concentrations in southern Ethiopia: A randomized trial.
    Food Sci Nutr 2017 Jul 7;5(4):921-928. Epub 2017 Apr 7.
    Oklahoma State UniversityStillwaterOklahomaUSA.
    Iodine deficiency during pregnancy and lactation could expose the infant to severe iodine deficiency disorders. A randomized supplementation trial among rural lactating women was conducted in Sidama zone, southern Ethiopia, to compare the methods of iodine delivery on breast milk iodine, and on maternal and infant urinary iodine concentrations. Women were randomly assigned either to receive 225 μg iodine as potassium iodide capsule daily for 6 months or 450 g of appropriately iodized salt (30-40 μg I as KIO3/g of salt) weekly for household consumption for 6 months. Read More

    Nutrition (Micronutrients) in Child Growth and Development: A Systematic Review on Current Evidence, Recommendations and Opportunities for Further Research.
    J Dev Behav Pediatr 2017 Jul 25. Epub 2017 Jul 25.
    *Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA; †Department of Nutrition, Children's Hospital Boston, Boston, MA.
    Objective: An important aspect of malnutrition is deficiency of different micronutrients during pregnancy or early childhood. We systematically reviewed the role of nutrition in child growth (weight or height gain) and development.

    Methods: A comprehensive literature search was done on PubMed/Cochrane Library browsing through 38,795 abstracts until December 31, 2016 to select systematic reviews/meta-analyses and individual randomized controlled trials (RCTs) of micronutrient supplementation. Read More

    Vitamin A, endocrine tissues and hormones: interplay and interactions.
    Endocr Connect 2017 Jul 18. Epub 2017 Jul 18.
    J Corcuff, Nuclear Medicine, University hospital of Bordeaux, Pessac, 33604, France
    Vitamin A (retinol) is a micronutrient critical for cell proliferation and differentiation. In adults, vitamin A and metabolites such as retinoic acid (RA) play major roles in vision, immune and brain functions, and tissue remodelling and metabolism. This review presents the physiological interactions of retinoids and endocrine tissues and hormonal systems. Read More

    Are lower TSH cutoffs in neonatal screening for congenital hypothyroidism warranted? A debate.
    Eur J Endocrinol 2017 Jul 10. Epub 2017 Jul 10.
    G Van Vliet, Peditarics, Ste-Justine Hospital, Montreal, H3T 1C5, Canada.
    When newborn screening (NBS) for congenital hypothyroidism (CH) using thyroid stimulating hormone (TSH) as a primary screening test was introduced, typical TSH screening cutoffs were 20 to 50 mU/L of whole blood. Over the years, lowering of TSH cutoffs has contributed to an increased prevalence of detected CH. However, a consensus on the benefit deriving from lowering TSH cutoffs at screening is lacking. Read More

    Is low iodine a risk factor for cardiovascular disease in Americans without thyroid dysfunction? Findings from NHANES.
    Nutr Metab Cardiovasc Dis 2017 Jul 15;27(7):651-656. Epub 2017 Jun 15.
    Department of Quantitative Health Sciences, University of Massachusetts Medical School, USA.
    Background And Aims: Low body iodine levels are associated with cardiovascular disease, in part through alterations in thyroid function. While this association suggested from animal studies, it lacks supportive evidence in humans. This study examined the association between urine iodine levels and presence of coronary artery disease (CAD) and stroke in adults without thyroid dysfunction. Read More

    Are Low Intakes and Deficiencies in Iron, Vitamin A, Zinc, and Iodine of Public Health Concern in Ethiopian, Kenyan, Nigerian, and South African Children and Adolescents.
    Food Nutr Bull 2017 Jan 1:379572117715818. Epub 2017 Jan 1.
    1 Unilever Research and Development, Vlaardingen, the Netherlands.
    Objective: To perform a systematic review to evaluate iron, vitamin A, zinc, and iodine status and intakes in children and adolescents (0-19 years) in Ethiopia, Kenya, Nigeria, and South Africa.

    Method: Both national and subnational data published from the year 2005 to 2015 were searched via MEDLINE, Scopus, and national public health websites. For each micronutrient and country, status data from relevant studies and surveys were combined into an average prevalence and weighted by sample size (WAVG). Read More

    Boron - A potential goiterogen?
    Med Hypotheses 2017 Jul 26;104:63-67. Epub 2017 May 26.
    Yaroslavl State University, Yaroslavl, Russia; RUDN University, Moscow, Russia; Orenburg State University, Orenburg, Russia.
    The iodine deficiency disorders (IDD) include a variety of disturbances such as decreased fertility, increased perinatal and infant mortality, impaired physical and intellectual development, mental retardation, cretinism, hypothyroidism, and endemic goiter (EG). The occurrence of the latter is determined by interplay between genetic and environmental factors. The major environmental factor is iodine status that is required for normal thyroid hormone synthesis. Read More

    Newborn Screening for Thyroid-stimulating Hormone as an Indicator for Assessment of Iodine Status in the Republic of Macedonia.
    J Med Biochem 2016 Oct 2;35(4):385-389. Epub 2016 Nov 2.
    Laboratory for Neonatal Thyroid Screening, Department of Endocrinology and Genetics, University Children's Hospital, Skopje, Republic of Macedonia.
    Background: Iodine deficiency is associated with goiter and impaired brain function leading to cretinism. An increased frequency of thyroid-stimulating hormone (TSH) measurements above 5 mlU/L on newborn screening points toward an impaired iodine status of the population.

    Methods: A 13-year retrospective analysis was performed in 228,266 newborns participating in the national thyroid newborn screening program. Read More

    First Israeli National Iodine Survey Demonstrates Iodine Deficiency Among School-Aged Children and Pregnant Women.
    Thyroid 2017 Aug;27(8):1083-1091
    1 Nutrition and Brain Health Laboratory, School of Nutritional Sciences and Institute of Biochemistry, Food Science and Nutrition, The Robert H. Smith Faculty of Agriculture, Food, and Environment, The Hebrew University of Jerusalem , Rehovot, Israel .
    Background: National data on iodine status in Israel are lacking. Reliance on iodine-depleted desalinated water, the absence of a salt iodization program, and reports of increased use of thyroid medication in Israel suggest that the population's iodine intake is likely inadequate. The aims of this study were therefore to determine the iodine status of Israeli school-age children (SAC) and pregnant women (PW) in a nationally representative sample obtained by a novel approach of using pre-discard urinalysis samples collected from a centralized national laboratory. Read More

    A PRISMA-compliant systematic review and meta-analysis of the relationship between thyroid disease and different levels of iodine intake in mainland China.
    Medicine (Baltimore) 2017 Jun;96(25):e7279
    Department of Nuclear Medicine, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
    Background: Low-iodine intake has historically been an issue in China, causing widespread iodine deficiency diseases (IDD). China started to introduce universal salt iodization in 1995, but reports of increased thyroid disease are a concern and appropriate levels of iodine intake must be considered.

    Objective: To assess the prevalence of thyroid disease with different urinary iodine concentrations (UICs) in the general population of those residing in mainland China. Read More

    Kikuchi-Fujimoto disease: a case report of a multi-drug resistant, grueling disease.
    Oxf Med Case Reports 2017 Jun 15;2017(6):omx024. Epub 2017 Jun 15.
    Pathology Department, Faculty of Medicine, Tishreen University, Lattakia, Syria.
    Histiocytic necrotizing lymphadenitis or Kikuchi-Fujimoto disease (KFD) is characterized by its rare occurrence. Mostly prevalent among Asian women, KFD manifests with lymphadenopathy-affecting mostly cervical and rarely generalized or retroperitoneal regions-in addition to fever. It is a self-limited disease that resolves within 1-4 months, responding remarkably to glucocorticosteroids or hydroxychloroquine. Read More

    Digenic DUOX1 and DUOX2 Mutations in Cases With Congenital Hypothyroidism.
    J Clin Endocrinol Metab 2017 Sep;102(9):3085-3090
    University of Cambridge Metabolic Research Laboratories, Wellcome Trust-Medical Research Council Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge CB2 0QQ, United Kingdom.
    Context: The DUOX2 enzyme generates hydrogen peroxide (H2O2), a crucial electron acceptor for the thyroid peroxidase-catalyzed iodination and coupling reactions mediating thyroid hormone biosynthesis. DUOX2 mutations result in dyshormonogenetic congenital hypothyroidism (CH) that may be phenotypically heterogeneous, leading to the hypothesis that CH severity may be influenced by environmental factors (e.g. Read More

    Spectrophotometric Determination of Selenium Through Triiodide Anion.
    Clin Lab 2017 May;63(5):887-899
    Background: Selenium is a chemical element found in the human body that plays a crucial role in its regulation. Depending on the concentration, it may have beneficial or have toxic effects. Selenium is incorporated as selenocysteine amino acid residue in selenoproteins which play an important role in many biological functions: anti-oxidant defense, regulation of the immune function and of the inflammatory response, metabolism of thyroid hormones, functioning of the central nervous system, biosynthesis of DNA and RNA, fertility, and reproduction. Read More

    Iodine levels are associated with oxidative stress and antioxidant status in pregnant women with hypertensive disease
    Nutr Hosp 2017 06 5;34(3):661-666. Epub 2017 Jun 5.
    instituto de salud publica, universidad veracruzana.
    Background: The antioxidant function of iodine and iodine deficiency as a risk factor of preeclampsia have been previously reported.

    Aim: To analyze the association between iodine deficiency, oxidative stress and antioxidant status with hypertensive disease of pregnancy (HPD).

    Method: Fifty-seven pregnant women were recruited in the last trimester of pregnancy; 20 were diagnosed with hypertensive disease (HPD) of pregnancy and 37 were normotensive pregnant women. Read More

    Identification of Organic Iodine Compounds and Their Transformation Products in Edible Iodized Salt Using Liquid Chromatography-High Resolution Mass Spectrometry.
    J Agric Food Chem 2017 Jul 26;65(26):5384-5389. Epub 2017 Jun 26.
    State Key Laboratory of Biogeology and Environmental Geology, China University of Geosciences , Wuhan, 430074, P. R. China.
    The consumption of edible iodized salt is a key strategy to control and eliminate iodine deficiency disorders worldwide. We herein report the identification of the organic iodine compounds present in different edible iodized salt products using liquid chromatography combined with high resolution mass spectrometry. A total of 38 organic iodine compounds and their transformation products (TPs) were identified in seaweed iodine salt from China. Read More

    Intrauterine death following intraamniotic triiodothyronine and thyroxine therapy for fetal goitrous hypothyroidism associated with polyhydramnios and caused by a thyroglobulin mutation.
    Endocrinol Diabetes Metab Case Rep 2017 7;2017. Epub 2017 Jun 7.
    University of Cambridge Metabolic Research Laboratories, Wellcome Trust-Medical Research Council Institute of Metabolic Science, Addenbrooke's Hospital, CambridgeUK.
    In the absence of maternal thyroid disease or iodine deficiency, fetal goitre is rare and usually attributable to dyshormonogenesis, for which genetic ascertainment is not always undertaken in the UK. Mechanical complications include tracheal and oesophageal compression with resultant polyhydramnios, malpresentation at delivery and neonatal respiratory distress. We report an Indian kindred in which the proband (first-born son) had congenital hypothyroidism (CH) without obvious neonatal goitre. Read More

    Endemic goitre and hypothyroidism in an adult female patient dependent on total parenteral nutrition.
    Endocrinol Diabetes Metab Case Rep 2017 7;2017. Epub 2017 Jun 7.
    Departments of Endocrinology.
    We present the case of a thirty-year-old female patient who was referred to the endocrinology team with an enlarging goitre and biochemical hypothyroidism. She had been dependent on total parenteral nutrition for the previous six years as a result of intestinal failure thought to be caused by possible underlying mitochondrial disease. The patient also suffers from a Desmin myopathy, and at present, the exact aetiology behind her intestinal failure is not certain. Read More

    Daily Consumption of Lipid-Based Nutrient Supplements Containing 250 μg Iodine Does Not Increase Urinary Iodine Concentrations in Pregnant and Postpartum Women in Bangladesh.
    J Nutr 2017 Aug 14;147(8):1586-1592. Epub 2017 Jun 14.
    Department of Nutrition, University of California, Davis, Davis, CA; and.
    Background: Maternal iodine deficiency during pregnancy and lactation is common in Bangladesh.Objective: We evaluated the effect of lipid-based nutrient supplements for pregnant and lactating women (LNS-PL) on urinary iodine concentration (UIC).Methods: We conducted a cluster-randomized controlled effectiveness trial in which we enrolled 4011 pregnant women at ≤20 gestational weeks. Read More

    Thirty-Five Years of Thyroid Cancer Experience in a Paediatric Population: Incidence Trends in Lithuania between 1980 and 2014.
    Eur Thyroid J 2017 Feb 9;6(1):40-46. Epub 2016 Nov 9.
    Clinic of Endocrinology, Lithuanian University of Health Sciences, Kaunas, Lithuania.
    Background: Thyroid cancer (TC) is a rare condition in children. It may be associated with radiation, iodine deficiency or familial inheritance.

    Aims: The objectives of this study were to analyse the prevalence and incidence trends over 3 decades and clinical features of TC in the paediatric population in Lithuania. Read More

    Pregnant Greek Women May Have a Higher Prevalence of Iodine Deficiency than the General Greek Population.
    Eur Thyroid J 2017 Feb 28;6(1):26-30. Epub 2016 Sep 28.
    Division of Endocrinology, University Medical School, University Hospital, Rion-Patras, Greece.
    Background: Adequate dietary iodine consumption, predicted via the urinary iodine concentration (UIC), is necessary for normal thyroid function and for the neurodevelopment of fetuses and neonates. The general population of Greece is considered to be iodine sufficient, but our preliminary findings suggest that Greek pregnant women are at risk of iodine deficiency.

    Objective: Our aim was to estimate the thyroid function and UIC in a representative population of pregnant Greek women. Read More

    Maternal Different Degrees of Iodine Deficiency during Pregnant and Lactation Impair the Development of Cerebellar Pinceau in Offspring.
    Front Neurosci 2017 29;11:298. Epub 2017 May 29.
    Department of Occupational and Environmental Health, School of Public Health, China Medical UniversityShenyang, China.
    Aims: Iodine is critical for synthesis of thyroid hormones (TH). And iodine deficiency (ID) is one of the most significant reasons of intellectual disability and motor memory impairment, although the potential mechanisms are still under investigation. Presently, mild ID and marginal ID are largely ignored problems for women of child bearing age. Read More

    Iodine Prophylaxis In The Lights Of The Last Recommendation Of Who On Reduction Of Daily Salt Intake.
    Recent Pat Endocr Metab Immune Drug Discov 2017 Jun 8. Epub 2017 Jun 8.
    Department of Endocrinology, Jagiellonian University, Collegium Medicum, Krakow. Poland.
    In 1994 international organizations: WHO,UNICEF and ICCIDD indicated salt - Natrium Chloride as a main carrier of iodine in the prophilaxis systems in the iodine deficient areas over the world. Following this recommendation 24 European countries introduced the model of iodine prophylaxis based on the salt iodization. However in 7 European countries only - among them in Poland - salt iodization is mandatory -as the most effective model on the population level. Read More

    Thyroglobulin level at week 16 of pregnancy is superior to urinary iodine concentration in revealing preconceptual and first trimester iodine supply.
    Matern Child Nutr 2017 Jun 7. Epub 2017 Jun 7.
    Division of Endocrinology, Department of Medicine, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
    Pregnant women are prone to iodine deficiency due to the increased need for iodine during gestation. Progress has recently occurred in establishing serum thyroglobulin (Tg) as an iodine status biomarker, but there is no accepted reference range for iodine sufficiency during pregnancy. An observational study was conducted in 164 pregnant women. Read More

    Consumption of Fish Is Not Associated with Risk of Differentiated Thyroid Carcinoma in the European Prospective Investigation into Cancer and Nutrition (EPIC) Study.
    J Nutr 2017 Jul 7;147(7):1366-1373. Epub 2017 Jun 7.
    International Agency for Research on Cancer, Lyon, France.
    Background: Differentiated thyroid cancer (TC) is the most common endocrine cancer. Fish can be an important source of iodine and other micronutrients and contaminants that may affect the thyroid gland and TC risk.Objective: We prospectively evaluated the relations between the consumption of total fish and different fish types and shellfish and TC risk in the EPIC (European Prospective Investigation into Cancer and Nutrition) study. Read More

    The influence of mandatory iodine fortification on the iodine status of Australian school children residing in an iodine sufficient region.
    Asia Pac J Clin Nutr 2017;26(4):680-685
    Children's Nutrition Research Centre, Child Health Research Centre, The University of Queensland, South Brisbane, Australia.
    Background And Objectives: To counter emerging iodine deficiency mandatory iodine fortification of bread was introduced throughout Australia in 2009. This study investigated the impact of iodine fortification on the iodine status of school aged children living in the iodine replete state of Queensland, and investigated which foods had greatest influence on overall iodine status.

    Methods And Study Design: A convenience sample of 30 children aged 8. Read More

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