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    Moderate iodine deficiency among pregnant women in Hong Kong: revisit the problem after two decades.
    Hong Kong Med J 2017 Nov 10. Epub 2017 Nov 10.
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong.
    Introduction: A survey conducted during 2005 to 2007 by the Centre for Food Safety in Hong Kong suggested that only 5% of the local population had a sufficient dietary intake of iodine. The study, however, was limited as biochemical data (ie urinary iodine concentration) were lacking. Pregnant women are vulnerable to iodine deficiency because of their increased requirement. Read More

    [Thyroid disease in the Czech Republic: the EUthyroid project and the evaluation of the General Health Insurance Company epidemiological data for the period of 2012-2015].
    Vnitr Lek 2017 ;63(9):548-554
    Institute of Endocrinology participates in the grant of European Commission EUthyroid (Towards the elimination of iodine deficiency and preventable thyroid-related diseases in Europe), together with other 28 European countries. The role of Institute of Endocrinology in EUthyroid is among other things to ensure access to national registers relating to thyroid diseases. The results presented here correspond to the years 2012-2015 and are based on data from the General Health Insurance Company Czech Republic (VZP CR), which has 6 million insured persons (ratio male : female = 1 : 1). Read More

    Iodine Status of Taiwanese Population in 2013: 10 Years After Changing From Mandatory to Voluntary Salt Iodization.
    Food Nutr Bull 2017 Jan 1:379572117738883. Epub 2017 Jan 1.
    2 National Yang-Ming University School of Medicine, Taipei, Taiwan.
    Background: Since 2003, Taiwan had iodine policy changes from mandatory to voluntary. The Nutrition and Health Survey in Taiwan (NAHSIT) 2001-2002 for schoolchildren showed an adequate iodine nutrition, while NAHSIT 2005-2008 for adults showed the iodine status was at borderline adequacy.

    Objective: To investigate the iodine status of the Taiwanese population from schoolchildren to adulthood 10 years after the change of the salt iodization policy. Read More

    Nutrients intake, and serum calcium and phosphorus levels: An evidence-based study.
    J Clin Lab Anal 2017 Nov 7. Epub 2017 Nov 7.
    Metabolic syndrome Research center, Mashhad University of Medical Sciences, Mashhad, Iran.
    Introduction: Dietary calcium and phosphorus appear to be important determinants of dyslipidemia and hypertension. We have investigated (1) the prevalence of hypocalcemia and hypophosphatemia in an Iranian population, and (2) the association between nutrient's intake and serum levels of calcium and phosphorus.

    Methods: A total of 908 individuals were enrolled using a stratified-cluster sampling method from the Mashhad stroke and heart atherosclerosis disorder (MASHHAD) study. Read More

    Iodized salt intake and its association with urinary iodine, TPOAb and TgAb among urban Chinese.
    Thyroid 2017 Nov 1. Epub 2017 Nov 1.
    Shanghai Ninth People's Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Endocrinology and Metabolism , No.639Zhizaoju Road, Shanghai, China , Shanghai, China , 200011 ;
    Background: Whether iodized salt increases the risk of thyroid diseases has been strongly debated in China, especially in the urban areas of coastal regions, in recent years. We aimed to investigate the status of iodized salt in terms of urinary and serum iodine concentration in urban coastal areas, and to further explore whether iodized salt or noniodized salt was associated with autoimmune thyroid disease (AITD).

    Methods: Our data source was SPECT-China (ChiCTR-ECS-14005052, www. Read More

    A First Report of Secondary Hemophagocytic Lymphohistiocytosis Associated With Papillary Thyroid Carcinoma.
    J Pediatr Hematol Oncol 2017 Oct 30. Epub 2017 Oct 30.
    *Division of Bone Marrow Transplantation and Immune Deficiency †Division of Endocrinology ‡Division of Oncology §Division of Radiology, Cincinnati Children's Hospital ∥Division of Hematology/Oncology, University of Cincinnati Medical Center, Cincinnati, OH.
    Secondary hemophagocytic lymphohistiocytosis (HLH) is a rare and potentially fatal immune-deficiency disorder that develops in response to diseases that produce strong immunologic activation, such as infection and malignancy. Although secondary HLH is reported to occur in association with various malignancies, there is no report of its association with thyroid cancer. We evaluated a 19-year-old man who presented with HLH. Read More

    The Impact of Iodine Status on the Recall Rate of the Screening Program for Congenital Hypothyroidism: Findings from Two National Studies in Iran.
    Nutrients 2017 Oct 30;9(11). Epub 2017 Oct 30.
    Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, 1985717413, Tehran, Iran.
    Back ground: Iodine deficiency is one of the important factors in increasing the recall rate in congenital hypothyroidism (CH) screening programs. The present study assessed whether the iodine status of the general population may predict the recall rate or vice versa.

    Methods: In the current national study, among 1,382,229 live births delivered between March 2010 and March 2011, 1,288,237 neonates were screened for detecting CH by TSH (thyroid stimulating hormone) measurement via heel prick sampling. Read More

    Dietary Iodine Exposure and Brain Structures and Cognition in Older People. Exploratory Analysis in the Lothian Birth Cohort 1936.
    J Nutr Health Aging 2017 ;21(9):971-979
    Dr. Maria C. Valdés Hernández, Department of Neuroimaging Sciences, Centre for Clinical Brain Sciences, University of Edinburgh, 49 Little France Crescent, Chancellor's Building, Edinburgh, EH16 4SB, UK. Telephone:+44-131-4659527, Fax: +44-131-3325150, E-mail:
    Background: Iodine deficiency is one of the three key micronutrient deficiencies highlighted as major public health issues by the World Health Organisation. Iodine deficiency is known to cause brain structural alterations likely to affect cognition. However, it is not known whether or how different (lifelong) levels of exposure to dietary iodine influences brain health and cognitive functions. Read More

    Effect of broccoli sprouts on thyroid function, haematological, biochemical, and immunological parameters in rats with thyroid imbalance.
    Biomed Pharmacother 2017 Oct 25;97:82-90. Epub 2017 Oct 25.
    Department of Food Chemistry and Nutrition, Medical College, Jagiellonian University, Medyczna 9, 30-688 Kraków, Poland.
    Broccoli sprouts may exert a negative influence on thyroid function as they are a rich source of glucosinolates, in particular glucoraphanin. Under the study in a long-term experiment broccoli sprouts were tested as an element of rats diet, combined with deficient iodine, or sulfadimethoxine ingestion - two models of hypothyroidism. Evaluations were performed for serum TSH and thyroid hormones completed with analyzes of selected haematological, biochemical and immunological (IL-6, IL-10) parameters, as well as cytosolic glutathione peroxidase (GPX1), thioredoxin reductase (TR) in the thyroid, and plasma glutathione peroxidase (GPX3). Read More

    [Caries prevention with fluoridated and iodinated salt in school-aged children living in areas with fluoride and iodine deficiency].
    Stomatologiia (Mosk) 2017 ;96(5):66-68
    Azerbaijan Medical Academy, Baku, Azerbaijan.
    The aim of the study was to evaluate the efficacy of dental caries prevention program with 3 years follow-up in children living in areas with fluoride and iodine deficiency. The study involved 625 school-aged children aged 6, 12 and 15 years receiving endogenous prevention with fluoridated and iodinated salt (300±50 mgF/kg and 40±10 mgI/kg). Enamel and dentine concentrations of CA, P, F and I were measured in 98 intact deciduous teeth by X-ray microanalysis before and after prevention program. Read More

    Interrelationship between iodine nutritional status of lactating mothers and their absolutely breast-fed infants in coastal districts of Gangetic West Bengal in India.
    Eur J Pediatr 2017 Oct 23. Epub 2017 Oct 23.
    Endocrinology and Reproductive Physiology Laboratory, Department of Physiology, University of Calcutta, University College of Science and Technology, 92, APC Road, Kolkata, West Bengal, 700 009, India.
    Iodine nutritional status of 128 lactating mothers and their breast-fed infants (1-3 months) from iodine-replete villages during post-salt iodization period was evaluated. Mothers' urine, blood, and breast milk (BM) and infants' urine and blood were collected and analyzed for iodine and serum FT4 and TSH estimation. Mothers' and infants' age, parity, occupation, education, and household income were recorded. Read More

    Phagocytosis Deficiency of Macrophages in NOD.H-2(h4) Mice Accelerates the Severity of Iodine-Induced Autoimmune Thyroiditis.
    Biol Trace Elem Res 2017 Oct 20. Epub 2017 Oct 20.
    Department of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, First Affiliated Hospital of China Medical University, No. 155 Nanjing North Street, Shenyang, Liaoning, 110001, China.
    Apoptosis occurs in many autoimmune diseases. Excess iodine induces thyrocyte apoptosis and increases the incidence and prevalence of autoimmune thyroiditis (AIT). However, the sequence of events between the appearance of thyrocyte apoptosis and the occurrence of thyroiditis remains uncharacterized. Read More

    Iodine nutritional status in Asturian schoolchildren.
    Endocrinol Diabetes Nutr 2017 Nov 24;64(9):491-497. Epub 2017 Aug 24.
    Servicio Endocrinología y Nutrición, Hospital Universitario Central de Asturias, Oviedo, España.
    Introduction: Iodine deficiency is a public health problem, and iodine nutritional status should therefore be regularly measured.

    Objective: To ascertain iodine nutritional status in Asturias and its relation to use of iodized salt and to other sociodemographic and nutritional parameters.

    Material And Methods: A descriptive, observational study was conducted in a random sample of schoolchildren aged 5 to 14 years, in whom urinary iodine levels were measured by high-performance liquid chromatography. Read More

    Microbial Transformation of Iodine: From Radioisotopes to Iodine Deficiency.
    Adv Appl Microbiol 2017 7;101:83-136. Epub 2017 Sep 7.
    Texas A&M University, Galveston, TX, United States.
    Iodine is a biophilic element that is important for human health, both as an essential component of several thyroid hormones and, on the other hand, as a potential carcinogen in the form of radioiodine generated by anthropogenic nuclear activity. Iodine exists in multiple oxidation states (-1, 0, +1, +3, +5, and +7), primarily as molecular iodine (I2), iodide (I(-)), iodate [Formula: see text] , or organic iodine (org-I). The mobility of iodine in the environment is dependent on its speciation and a series of redox, complexation, sorption, precipitation, and microbial reactions. Read More

    Evaluation of serum ferritin and thyroid function in the second trimester of pregnancy.
    Endocr J 2017 Oct 13. Epub 2017 Oct 13.
    Department of Endocrinology, Fifth People's Hospital of Shanghai Fudan University, Shanghai, China.
    Ferritin is a universal intracellular protein that acts as an iron carrier. Several studies have indicated that iron deficiency affects thyroid function in non-pregnant women. Our objective was to assess the relationship between serum ferritin levels and thyroid function in pregnant women during the second trimester. Read More

    Has iodized salt reduced iodine-deficiency disorders among school-aged children in north-west Iran? A 9-year prospective study.
    Public Health Nutr 2017 Oct 16:1-8. Epub 2017 Oct 16.
    3Social Determinants of Health Research Center,Urmia University of Medical Science,Urmia,Islamic Republic of Iran.
    Objective: Low iodine intakes are associated with goitre and other iodine-deficiency disorders (IDD) that have affected billions of people worldwide. We aimed to assess total goitre rate (TGR) and urinary iodine concentration (UIC) in schoolchildren between 2007 and 2015, percentage of iodized salt consumption by households, and salt iodine content at production, distribution and household levels in north-west Iran. Design/Setting/Subjects UIC assessed among schoolchildren in nine consecutive years; 240 schoolchildren aged 8-10 years selected by systematic random sampling each year in the West Azerbaijan Province. Read More

    Effect of iodine supplementation in pregnant women on child neurodevelopment: a randomised, double-blind, placebo-controlled trial.
    Lancet Diabetes Endocrinol 2017 Nov 10;5(11):853-863. Epub 2017 Oct 10.
    Department of Health Sciences and Technology, Swiss Federal Institute of Technology (ETH), Zurich, Switzerland. Electronic address:
    Background: Iodine deficiency during pregnancy might be associated with reduced intelligence quotient (IQ) score in offspring. We assessed the effect of iodine supplementation in mildly iodine-deficient pregnant women on neurodevelopment of their offspring in areas where schoolchildren were iodine sufficient.

    Methods: In this randomised, placebo-controlled trial, pregnant women in Bangalore, India, and Bangkok, Thailand, were randomly assigned (1:1) to receive 200 μg iodine orally once a day or placebo until delivery. Read More

    Socio-demographic characters, distribution and transformation of iodine in soil, plant and wheat grains at District Diamer, Gilgit-Baltistan, Pakistan.
    Environ Geochem Health 2017 Oct 12. Epub 2017 Oct 12.
    Centre for Climate Research and Development (CCRD), COMSATS Institute of Information Technology, Park Road, Chak Shahzad, Islamabad, 45550, Pakistan.
    Iodine deficiency in soils and plants is a common problem in the hilly areas and has still been ignored. The aim of the current study is to investigate associated health issues, socio-economic characteristics and people's perception regarding iodine deficiency. Furthermore, a follow-up study was conducted to determine iodine and nutrients concentration in soil and crops at District Diamer, Gilgit-Baltistan, Pakistan. Read More

    Imaging of Nonmalignant Adrenal Lesions in Children.
    Radiographics 2017 Oct;37(6):1648-1664
    From the Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 S Kingshighway Blvd, Campus Box 8131-MIR, St Louis, MO 63110.
    The adrenal glands in children can be affected by a variety of benign lesions. The diagnosis of adrenal lesions can be challenging, but assessment of morphologic changes in correlation with the clinical presentation can lead to an accurate diagnosis. These lesions can be classified by their cause: congenital (eg, discoid adrenal gland, horseshoe adrenal gland, and epithelial cysts), vascular and/or traumatic (eg, adrenal hemorrhage), infectious (eg, granulomatous diseases), enzyme deficiency disorders (eg, congenital adrenal hyperplasia [CAH] and Wolman disease), benign neoplasms (eg, pheochromocytomas, ganglioneuromas, adrenal adenomas, and myelolipomas), and adrenal mass mimics (eg, extralobar sequestration and extramedullary hematopoiesis). Read More

    Iodine and Thyroid Function Status, and Anti-thyroid Peroxidase Antibody among Pregnant Women in Eastern Nepal.
    J Nepal Health Res Counc 2017 Sep 8;15(2):114-119. Epub 2017 Sep 8.
    Department of Biochemistry, B P Koirala Institute of Health Sciences, Sunsari, Nepal.
    Background: Iodine deficiency, thyroid dysfunction and development of thyroid autoimmunity during pregnancy may affect mother and the developing fetus. This study was carried out to find iodine status, thyroid dysfunction and thyroid autoimmunity among pregnant women.

    Methods: Ninety two pregnant women from three districts of eastern Nepal (Sunsari, Morang and Jhapa) were enrolled for the study, and urine and blood samples were collected. Read More

    Micronutrient Status and Dietary Intake of Iron, Vitamin A, Iodine, Folate and Zinc in Women of Reproductive Age and Pregnant Women in Ethiopia, Kenya, Nigeria and South Africa: A Systematic Review of Data from 2005 to 2015.
    Nutrients 2017 Oct 5;9(10). Epub 2017 Oct 5.
    Unilever Research & Development, Vlaardingen, 3130 AC, The Netherlands.
    A systematic review was conducted to evaluate the status and intake of iron, vitamin A, iodine, folate and zinc in women of reproductive age (WRA) (≥15-49 years) and pregnant women (PW) in Ethiopia, Kenya, Nigeria and South Africa. National and subnational data published between 2005 and 2015 were searched via Medline, Scopus and national public health websites. Per micronutrient, relevant data were pooled into an average prevalence of deficiency, weighted by sample size (WAVG). Read More

    Societal Costs of Micronutrient Deficiencies in 6- to 59-month-old Children in Pakistan.
    Food Nutr Bull 2017 Dec 2;38(4):485-500. Epub 2017 Oct 2.
    3 Center of Excellence in Women and Child Health, The Aga Khan University, Karachi, Pakistan.
    Background: In Pakistan, nearly half of children younger than 5 years are stunted, and 1 in 3 is underweight. Micronutrient deficiencies, a less visible form of undernutrition, are also endemic. They may lead to increased morbidity and mortality as well as to impaired cognitive and physical development. Read More

    Severe selenium deficits in pregnant women irrespective of autoimmune thyroid disease in an area with marginal selenium intake.
    J Trace Elem Med Biol 2017 Dec 4;44:186-191. Epub 2017 Aug 4.
    Institute for Experimental Endocrinology, Charité-Universitätsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany.
    Objectives: Selenium (Se) deficiency is related to an increased risk of preterm labor, miscarriage, preeclampsia, gestational diabetes, and other obstetric complications. As the Se status declines during pregnancy, we hypothesized that the decline may be exacerbated in women with autoimmune thyroid disease (AITD).

    Material And Methods: Pregnant women (n=74; 30 [23-38] years) were consecutively recruited from the district of Warsaw, Poland, and divided into healthy subjects (HS, n=45), and women with a diagnosis of AITD (AITD, n=29). Read More

    Body iodine status in women with postmenopausal osteoporosis.
    Menopause 2017 Sep 25. Epub 2017 Sep 25.
    1Department of Obstetrics and Gynecology, Yenimahalle Training and Research Hospital, Ankara, Turkey 2Department of Obstetrics and Gynecology, Ankara Training and Research Hospital, Ankara, Turkey 3Department of Obstetrics and Gynecology, Ankara University Hospital, Ankara, Turkey 4Department of Obstetrics and Gynecology, Antalya Training and Research Hospital, Antalya, Turkey.
    Objective: Postmenopausal osteoporosis is a frequent cause of morbidity and can negatively impact life expectancy; iodine is an essential element for bone mineralization, and iodine deficiency is frequently observed. The aim of the present study was to understand the connection between postmenopausal osteoporosis and the level of iodine in the body.

    Methods: A total of 132 participants were divided into three groups: group 1 consisted of healthy postmenopausal women (n = 34), group 2 comprised osteopenic women (n = 38), and group 3 included women with postmenopausal osteoporosis (n = 60). Read More

    Iodine concentration of milk-alternative drinks available in the UK in comparison with cows' milk.
    Br J Nutr 2017 Oct 26;118(7):525-532. Epub 2017 Sep 26.
    1Department of Nutritional Sciences, Faculty of Health and Medical Sciences,University of Surrey,Guildford,Surrey GU2 7XH,UK.
    Iodine deficiency is present in certain groups of the UK population, notably in pregnant women; this is of concern as iodine is required for fetal brain development. UK milk is rich in iodine and is the principal dietary iodine source. UK sales of milk-alternative drinks are increasing but data are lacking on their iodine content. Read More

    Vitamin D deficiency affects thyroid autoimmunity and dysfunction in iodine-replete area: Korea national health and nutrition examination survey.
    Endocrine 2017 Nov 21;58(2):332-339. Epub 2017 Sep 21.
    Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, Korea.
    Purpose: We evaluated the effects of vitamin D levels and iodine intake on thyroid autoimmunity and dysfunction in the Korean population.

    Methods: In this nationwide population-based study, data were obtained from the Korea National Health and Nutrition Examination Survey VI-1 and 2 (2013 and 2014), which was the first nationwide survey that measured both serum 25-hydroxy vitamin D [25(OH)D] levels and urinary iodine concentrations (UICs) in Korea. A total of 4181 participants who underwent laboratory tests for thyroid function, serum 25(OH)D levels, and UICs were included. Read More

    Iodine Intake through Processed Food: Case Studies from Egypt, Indonesia, the Philippines, the Russian Federation and Ukraine, 2010-2015.
    Nutrients 2017 Jul 26;9(8). Epub 2017 Jul 26.
    Large Scale Food Fortification Initiative, Global Alliance for Improved Nutrition, 1202 Geneva, Switzerland.
    The current performance indicator for universal salt iodisation (USI) is the percentage of households using adequately iodised salt. However, the proportion of dietary salt from household salt is decreasing with the increase in consumption of processed foods and condiments globally. This paper reports on case studies supported by the Global Alliance for Improved Nutrition (GAIN)-UNICEF USI Partnership Project to investigate processed food industry use of adequately iodised salt in contrasting national contexts. Read More

    mHealth Application Areas and Technology Combinations*. A Comparison of Literature from High and Low/Middle Income Countries.
    Methods Inf Med 2017 Aug 8;56(7):e105-e122. Epub 2017 Aug 8.
    Haitham Abaza, Peter L. Reichertz Institute for Medical Informatics, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany, E-mail:
    Background: With the continuous and enormous spread of mobile technologies, mHealth has evolved as a new subfield of eHealth. While eHealth is broadly focused on information and communication technologies, mHealth seeks to explore more into mobile devices and wireless communication. Since mobile phone penetration has exceeded other infrastructure in low and middle-income countries (LMICs), mHealth is seen as a promising component to provide pervasive and patient-centered care. Read More

    Snack and beverage consumption and preferences in a sample of Chinese children - Are they influenced by advertising?
    Asia Pac J Clin Nutr 2017 ;26(6):1125-1132
    Sydney School of Public Health, the University of Sydney, Sydney, Australia.
    Background And Objectives: The consumption of unhealthy snack and beverages can lead to childhood obesity, which has become a major concern globally. Television food advertisements may influence children's snack and beverages preferences. This article aims to explore children's snack and beverage consumption habits; examine the extent of television advertising for non-core (energy-dense, nutrient poor) snack and beverages; and assess the influence of television advertising on children's snack and beverages preferences in Harbin, China. Read More

    A Paleolithic-type diet results in iodine deficiency: a 2-year randomized trial in postmenopausal obese women.
    Eur J Clin Nutr 2017 Sep 13. Epub 2017 Sep 13.
    Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden.
    Background/objectives: Different diets are used for weight loss. A Paleolithic-type diet (PD) has beneficial metabolic effects, but two of the largest iodine sources, table salt and dairy products, are excluded. The objectives of this study were to compare 24-h urinary iodine concentration (24-UIC) in subjects on PD with 24-UIC in subjects on a diet according to the Nordic Nutrition Recommendations (NNR) and to study if PD results in a higher risk of developing iodine deficiency (ID), than NNR diet. Read More

    The legislative framework for salt iodization in Asia and the Pacific and its impact on programme implementation.
    Public Health Nutr 2017 Nov 7;20(16):3008-3018. Epub 2017 Sep 7.
    4Evidence and Programme Guidance,Department of Nutrition for Health and Development,World Health Organization,Geneva,Switzerland.
    Objective: Fortification of food-grade (edible) salt with iodine is recommended as a safe, cost-effective and sustainable strategy for the prevention of iodine-deficiency disorders. The present paper examines the legislative framework for salt iodization in Asian countries.

    Design: We reviewed salt iodization legislation in thirty-six countries in Asia and the Pacific. Read More

    THYROID CANCER CONSEQUENCES OF IODINE DEFICIENCY - A PERSISTING WORLDWIDE PROBLEM: CHARACTERISTICS IN DIFFERENT POPULATIONS, PORTUGAL AND SOUTH AFRICA.
    S Afr J Surg 2017 Sep;55(3):69
    University of Beira Interior, and Centro Hospitalar Cova da Beira, Hospital da Covilhã, and CICS-UBI Health Sciences Research Centre, Faculty of Health Sciences, University of Beira Interior.
    Background: Iodine deficiency (ID) still affects over two billion people worldwide (266 million school aged children). Pathology patterns in ID include: increase in thyroid cancer, higher percentages of follicular and anaplastic cancers and inversion of the papillary/follicular thyroid cancer frequency ratio. China succeeded in eliminating ID through legislation introduced in 1987 aimed at availability of iodized salt countrywide and South Africa through legislation introduced in 1995. Read More

    [Cytokine dysregulation in children with chronic catarrhal gingivitis living in polluted areas with fluoride and iodine deficiency].
    Stomatologiia (Mosk) 2017 ;96(4):48-51
    Lvov National Medical University named after Danila Galizkiy, Lvov, Ukraine.
    The aim of the research was to study the state of oral liquid immunity in children with chronic catarrhal gingivitis living in unfavorable environmental conditions. The study included 190 children with chronic catarrhal gingivitis (CCG): 110 children aged 7, 12 and 15 years and residing in ecologically unfavorable areas of Lviv region and 80 children living in 'conditionally clean' region which constituted comparison group. Children with CCG from polluted areas had increased content of pro-inflammatory cytokines and reduction of anti-inflammatory cytokines compared to controls. Read More

    Association of obesity and diabetes with thyroid nodules.
    Endocrine 2017 Aug 23. Epub 2017 Aug 23.
    Dipartimento Biomedico di Medicina Interna e Specialistica (DIBIMIS) - University of Palermo (Italy), Via del Vespro 129, 90127, Palermo, Italy.
    Aim: There are conflicting data concerning the possibility that obesity and diabetes raise the risk of thyroid nodules. The incidence of thyroid nodules is increasing, as is that of obesity and diabetes; therefore, understanding whether these metabolic and nutritional disorders influence nodular thyroid disease is important for organizing prevention strategies. This study investigated the association between thyroid nodules, obesity, diabetes, and dietary habits. Read More

    Evaluation of Bone Density, Serum Total and Ionized Calcium, Alkaline Phosphatase and 25-hydroxy Vitamin D in Papillary Thyroid Carcinoma, and their Relationship with TSH Suppression by Levothyroxine.
    Adv Biomed Res 2017 28;6:94. Epub 2017 Jul 28.
    Department of Biostatistics, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
    Background: This study aimed to evaluate the situation of Bone Mineral Density (BMD), Z score, T score, serum level of corrected and ionized calcium, alkaline phosphatase and 25-hydroxy vitamin D in percutaneous transhepatic cholangiography (PTC) patients and correlation of these variants with thyroid stimulating hormone (TSH) suppression level by levothyroxine.

    Materials And Methods: Among the patients referred to Esfahan's endocrinology research center, 34 PTC patients (aged 20-50 years) with a history of thyroidectomy and conceived radioactive iodine and suppressive dose of levothyroxine were evaluated in this case-control study, and 38 healthy persons participated as the control group (matched by age and sex, body mass index). Bone density was evaluated with the DEXA method in four areas: Lumbar spine, femoral neck, and trochanter and distal of forearm. Read More

    Iodine excess exposure during pregnancy and lactation impairs maternal thyroid function in rats.
    Endocr Connect 2017 Oct 16;6(7):510-521. Epub 2017 Aug 16.
    Department of Physiology and BiophysicsInstitute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil
    Adequate maternal iodine consumption during pregnancy and lactation guarantees normal thyroid hormones (TH) production, which is crucial to the development of the fetus. Indeed, iodine deficiency is clearly related to maternal hypothyroidism and deleterious effects in the fetal development. Conversely, the effects of iodine excess (IE) consumption on maternal thyroid function are still controversial. Read More

    Maternal hypothyroidism: An overview of current experimental models.
    Life Sci 2017 Oct 12;187:1-8. Epub 2017 Aug 12.
    Endocrine Physiology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address:
    Maternal hypothyroidism (MH) is the most common cause of transient congenital hypothyroidism. Different animal models are used for assessing developmental effects of MH in offspring. The severity and status of hypothyroidism in animal models must be a reflection of the actual conditions in humans. Read More

    Iodine-Rich Herbs and Potassium Iodate Have Different Effects on the Oxidative Stress and Differentiation of TH17 Cells in Iodine-Deficient NOD.H-2(h4) Mice.
    Biol Trace Elem Res 2017 Aug 12. Epub 2017 Aug 12.
    The First Clinical College, Liaoning University of Traditional Chinese Medicine (TCM), Chongshan East Road No.72, Shenyang, Liaoning, 110032, China.
    Iodine-rich herbs such as seaweed, kelp, and sea tangle were widely used to treat various types of goiter with good effect and without any adverse side effects in China. When compared with potassium iodate (PI), iodine-rich herbs had a positive effect on the recovery of goiter resulting from iodine deficiency without any obvious harmful effects. In NOD. Read More

    Iodine status among pregnant women in rural Sabah, Malaysia.
    Asia Pac J Clin Nutr 2017 ;26(5):861-866
    School of Health Sciences, Universiti Sains Malaysia, Kelantan, Malaysia.
    Background And Objectives: In 2000, legislation on mandatory universal salt iodisation was enacted in Sabah, Malaysia, to reduce the incidence of iodine deficiency disorders among its population. To evaluate the iodine levels among pregnant women from selected rural divisions in Sabah 13 years after the enactment of the universal salt iodisation programme.

    Methods And Study Design: This cross-sectional study was conducted from 1 May to 30 June, 2013, in three rural divisions of Sabah (the Interior, the West Coast, and Kudat). Read More

    Iodine status of postpartum women and their infants in Australia after the introduction of mandatory iodine fortification.
    Br J Nutr 2017 Jun;117(12):1656-1662
    1School of Agriculture, Food and Wine,Foodplus Research Centre,University of Adelaide,PMB 1, Glen Osmond, SA 5064,Australia.
    Mandatory I fortification in bread was introduced in Australia in 2009 in response to the re-emergence of biochemical I deficiency based on median urinary I concentration (UIC)<100 µg/l. Data on the I status of lactating mothers and their infants in Australia are scarce. The primary aim of this study was to assess the I status, determined by UIC and breast milk I concentration (BMIC), of breast-feeding mothers in South Australia and UIC of their infants. Read More

    Availability of adequately iodized in Northwest Ethiopia: a cross-sectional study.
    Arch Public Health 2017 31;75:33. Epub 2017 Jul 31.
    Department of Epidemiology and Biostatistics, Institute of Public Health, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
    Background: Universal salt iodization is the most cost-effective, safe and sustainable strategy to eliminate iodine deficiency disorders. However, little is known about the availability of adequately iodized salt in the northwestern part of Ethiopia. Thus, the aim of this study was to assess the availability of adequately iodized salt at the household level and associated factors in Dabat District, northwest Ethiopia. Read More

    Promoting Early Child Development With Interventions in Health and Nutrition: A Systematic Review.
    Pediatrics 2017 Aug;140(2)
    Centre for Global Child Health, The Hospital for Sick Children, Toronto, Ontario, Canada; and
    Context: Although effective health and nutrition interventions for reducing child mortality and morbidity exist, direct evidence of effects on cognitive, motor, and psychosocial development is lacking.

    Objective: To review existing evidence for health and nutrition interventions affecting direct measures of (and pathways to) early child development.

    Data Sources: Reviews and recent overviews of interventions across the continuum of care and component studies. Read More

    Effect of Iodine Nutrition on Pregnancy Outcomes in an Iodine-Sufficient Area in China.
    Biol Trace Elem Res 2017 Aug 2. Epub 2017 Aug 2.
    Department of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, First Affiliated Hospital of China Medical University, Shenyang, Liaoning Province, People's Republic of China.
    Many studies focused on the association between thyroid disease and pregnancy outcomes. The present study explored the effect of iodine nutrition during the first trimester on pregnancy outcomes. One thousand five hundred sixty-nine pregnant, euthyroid women at ≤12 weeks of gestation in an iodine-sufficient area in China were recruited. Read More

    Iodine Status After Bariatric Surgery-a Prospective 10-Year Report from the Swedish Obese Subjects (SOS) Study.
    Obes Surg 2017 Aug 2. Epub 2017 Aug 2.
    Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
    Context: Bariatric surgery can lead to nutrient deficiencies. Gastric by-pass (GBP) entails restriction and malabsorption, whereas, vertical banded gastroplasty (VBG) is only restrictive.

    Objective: The objective of this study is to study whether GBP-patients develop iodine deficiency from malabsorption, and if GBP- and VBG-patients develop lower 24-h urinary iodine excretion (24-UIE) than obese non-operated controls (OB-controls) due to lower iodine intake. Read More

    Assessing Selenium, Manganese, and Iodine Status in Pediatric Patients Receiving Parenteral Nutrition.
    Nutr Clin Pract 2017 Aug 14;32(4):552-556. Epub 2017 Mar 14.
    1 Department of Pharmacy, Primary Children's Hospital, Salt Lake City, Utah, USA.
    Background: Pediatric patients who are receiving parenteral nutrition (PN) unsupplemented with trace minerals can become deficient. Due to shortages in trace mineral products and the 2004 American Society for Parenteral and Enteral Nutrition report stating that individualized trace element supplementation may be warranted, a review was conducted concerning the trace minerals selenium (Se), manganese (Mn), and iodine (I).

    Method: A retrospective review of pediatric patients receiving PN that contained Se and Mn was conducted to determine if a difference existed between them and patients receiving PN without Se and Mn. Read More

    Double Fortified Salt Intervention Improved Iron Intake But Not Energy and Other Nutrient Intakes in Female Tea Plantation Workers From West Bengal, India.
    Food Nutr Bull 2017 Sep 31;38(3):369-383. Epub 2017 Jul 31.
    2 Division of Nutritional Sciences, Cornell University, Ithaca, NY, USA.
    Background: Iron deficiency is a global public health concern and has implications on the health status of women in reproductive age.

    Objective: We hypothesized that improving iron intake with double fortified salt would improve food intake, resulting in higher energy, nutrient intakes, and weight indicators of female tea plantation workers.

    Methods: In this randomized double-masked study, the participants (n = 245) were assigned to receive salt double fortified with iron and iodine (DFS; treatment) or salt fortified with iodine (control) and followed for 7. Read More

    Serum Thyroglobulin-A Sensitive Biomarker of Iodine Nutrition Status and Affected by Thyroid Abnormalities and Disease in Adult Populations.
    Biomed Environ Sci 2017 Jul;30(7):508-516
    Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University; Key Lab of Etiology and Epidemiology, National Health and Family Planning Commission (23618504), Harbin 150086, Heilongjiang, China.
    Objective: To evaluate the usefulness of the thyroglobulin (Tg) level in adults as a nutritional biomarker of iodine status and to identify the factors related to the serum Tg level.

    Methods: A cross-sectional study was conducted in adult populations of areas differing in iodine nutrition from three provinces (Autonomous Region) in China. Serum levels of thyroid hormones and Tg as well as thyroid autoantibodies were measured. Read More

    Re-establishment of normal radioactive iodine uptake reference range in the era of universal salt iodization in the Indian population.
    Indian J Med Res 2017 Mar;145(3):358-364
    Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi, India.
    Background & Objectives: The reference radioactive iodine uptake (RAIU) values established in the 1970s in the era of widespread iodine deficiency were relatively high. Now, after four decades of successful Universal Salt Iodization (USI) programme in India, there is a need to re-establish these reference ranges. The present study was aimed to quantify the two-hour and 24-h RAIU values in iodine sufficient euthyroid individuals and validate the results in Graves' and Hashimoto's thyroiditis patients. Read More

    Comparison of two sources of iodine delivery on breast milk iodine and maternal and infant urinary iodine concentrations in southern Ethiopia: A randomized trial.
    Food Sci Nutr 2017 Jul 7;5(4):921-928. Epub 2017 Apr 7.
    Oklahoma State UniversityStillwaterOklahomaUSA.
    Iodine deficiency during pregnancy and lactation could expose the infant to severe iodine deficiency disorders. A randomized supplementation trial among rural lactating women was conducted in Sidama zone, southern Ethiopia, to compare the methods of iodine delivery on breast milk iodine, and on maternal and infant urinary iodine concentrations. Women were randomly assigned either to receive 225 μg iodine as potassium iodide capsule daily for 6 months or 450 g of appropriately iodized salt (30-40 μg I as KIO3/g of salt) weekly for household consumption for 6 months. Read More

    Nutrition (Micronutrients) in Child Growth and Development: A Systematic Review on Current Evidence, Recommendations and Opportunities for Further Research.
    J Dev Behav Pediatr 2017 Oct;38(8):665-679
    *Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA; †Department of Nutrition, Children's Hospital Boston, Boston, MA.
    Objective: An important aspect of malnutrition is deficiency of different micronutrients during pregnancy or early childhood. We systematically reviewed the role of nutrition in child growth (weight or height gain) and development.

    Methods: A comprehensive literature search was done on PubMed/Cochrane Library browsing through 38,795 abstracts until December 31, 2016 to select systematic reviews/meta-analyses and individual randomized controlled trials (RCTs) of micronutrient supplementation. Read More

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