Search our Database of Scientific Publications and Authors

I’m looking for a

    5689 results match your criteria Iodine Deficiency

    1 OF 114

    Follicular Thyroid Carcinoma in a Country of Endemic Iodine Deficiency (1994-2013).
    J Thyroid Res 2018 25;2018:6516035. Epub 2018 Feb 25.
    Department of Pathology, Korle-Bu Teaching Hospital, P.O. Box 77, Korle-Bu, Accra, Ghana.
    Background: Follicular thyroid cancer (FTC) has historically been linked to iodine deficiency. Although Ghana is among the iodine deficient regions of the world, the proportions, trends, and the clinical features of FTCs have not been studied as a single disease entity. The aim of this study was to determine the relative frequencies, trends, and the clinicopathological characteristics of FTCs among all thyroid malignancies in our institution. Read More

    Iodine status of pregnant women from a coastal Brazilian state after the reduction in recommended iodine concentration in table salt according to governmental requirements.
    Nutrition 2018 Feb 14;53:109-114. Epub 2018 Feb 14.
    Endocrinology Service, Clementino Fraga Filho University Hospital, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. Electronic address:
    Objective: To evaluate iodine status among pregnant women from a coastal state after Brazilian governmental resolution reducing iodine concentrations in table salt. Secondarily, we correlated urinary iodine concentration (UIC) with thyroid volume and hormones.

    Methods: Inductively coupled plasma mass spectrometry was used to assess UIC from 629 samples of 244 first trimester pregnant women. Read More

    Iodine Deficiency in a Study Population of Norwegian Pregnant Women-Results from the Little in Norway Study (LiN).
    Nutrients 2018 Apr 20;10(4). Epub 2018 Apr 20.
    Institute of Marine Research (IMR), P.O. Box 1870 Nordnes, 5817 Bergen, Norway.
    Iodine sufficiency is particularly important in pregnancy, where median urinary iodine concentration (UIC) in the range of 150⁻250 µg/L indicates adequate iodine status. The aims of this study were to determine UIC and assess if dietary and maternal characteristics influence the iodine status in pregnant Norwegian women. The study comprises a cross-sectional population-based prospective cohort of pregnant women (Little in Norway (LiN)). Read More

    Changes in trophoblasts gene expression in response to perchlorate exposition.
    Toxicol In Vitro 2018 Apr 16. Epub 2018 Apr 16.
    Ecology and Health Laboratory, Public Health Institute, Universidad Veracruzana, Av. Luís Castelazo Ayala W/N, Col. Industrial Animas, Xalapa, Veracruz ZC 41190, Mexico. Electronic address:
    Contaminated water with chlorates is a public health problem associated with iodine deficiency. Epidemiological evidence shows that iodine deficiency is a risk factor for preeclampsia (PE). In this study we use human BeWo trophoblast cells exposed to perchlorate (KClO) and changes in gene expression were analyzed by microarrays, quantitative RT-PCR (qRT-PCR) and immunoblot. Read More

    Regression Analysis to Identify Factors Associated with Household Salt Iodine Content at the Sub-National Level in Bangladesh, India, Ghana and Senegal.
    Nutrients 2018 Apr 19;10(4). Epub 2018 Apr 19.
    Iodine Global Network, Seattle, WA 98107, USA.
    Regression analyses of data from stratified, cluster sample, household iodine surveys in Bangladesh, India, Ghana and Senegal were conducted to identify factors associated with household access to adequately iodised salt. For all countries, in single variable analyses, household salt iodine was significantly different ( < 0.05) between strata (geographic areas with representative data, defined by survey design), and significantly higher ( < 0. Read More

    Potassium iodate levels in processed edible salts available in retail shops throughout Kenya, 2013.
    Public Health Nutr 2018 Apr 19:1-3. Epub 2018 Apr 19.
    2Field Epidemiology and Laboratory Training Program,Ministry of Health,Nairobi,Kenya.
    Objective: Iodine-deficiency disorders, due to insufficiency of iodine in the diet, are a global public health problem. The Kenyan Food, Drugs and Chemical Substances Act stipulates that processed retail-available edible salts contain 50-84 mg of potassium iodate (KIO3) per kilogram of salt. The present study determined the status of KIO3 levels in commercial salts, for public health action. Read More

    Assessment of Iodine Nutritional Status of School-Age Children in Kolkata District of West Bengal State in Post-Iodation Scenario.
    J Trop Pediatr 2018 Apr 6. Epub 2018 Apr 6.
    To evaluate the state of iodine nutrition in post-iodation scenario, 3500 children were examined clinically for endemic goitre. Iodine and thiocyanate were measured in 240 urine samples; iodine content in 210 salt samples was measured. Total goitre prevalence was 6. Read More

    Universal Salt Iodization Provides Sufficient Dietary Iodine to Achieve Adequate Iodine Nutrition during the First 1000 Days: A Cross-Sectional Multicenter Study.
    J Nutr 2018 Apr;148(4):587-598
    Human Nutrition Laboratory, Institute of Food Nutrition and Health, ETH Zurich, Zurich, Switzerland.
    Background: Dietary iodine requirements are high during pregnancy, lactation, and infancy, making women and infants vulnerable to iodine deficiency. Universal salt iodization (USI) has been remarkably successful for preventing iodine deficiency in the general population, but it is uncertain if USI provides adequate iodine intakes during the first 1000 d.

    Objective: We set out to assess if USI provides sufficient dietary iodine to meet the iodine requirements and achieve adequate iodine nutrition in all vulnerable population groups. Read More

    Iodine nutrition status and prevalence of abnormal TSH levels in schoolchildren aged 6-7 years in the autonomous community of the Basque Country.
    Endocrinol Diabetes Nutr 2018 Apr 10. Epub 2018 Apr 10.
    Servicio de Endocrinología y Nutrición, Hospital de Sant Joan Despí Moisès Broggi, Sant Joan Despí (Barcelona), España.
    Introduction: An epidemiological study conducted between 1988 and 1992 showed iodine deficiency and endemic goiter in the schoolchildren of the autonomous community of the Basque Country.

    Objectives: 1) To ascertain the iodine nutrition status of schoolchildren aged 6-7 years, and 2) to estimate the prevalence of abnormal TSH levels in capillary blood.

    Population And Methods: The study was conducted on 497 schoolchildren selected by random sampling. Read More

    Role of iodine-containing multivitamins during pregnancy for children's brain function: protocol of an ongoing randomised controlled trial: the SWIDDICH study.
    BMJ Open 2018 Apr 10;8(4):e019945. Epub 2018 Apr 10.
    Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden.
    Introduction: Iodine is essential for normal brain development. Moderate and severe fetal iodine deficiency results in substantial to serious developmental delay in children. Mild iodine deficiency in pregnancy is associated with neurodevelopmental deficits in the offspring, but evidence from randomised trials is lacking. Read More

    Education and micronutrient deficiencies: an ecological study exploring interactions between women's schooling and children's micronutrient status.
    BMC Public Health 2018 Apr 10;18(1):470. Epub 2018 Apr 10.
    Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA, 02111, USA.
    Background: Formal education can be a nutrition-sensitive intervention that supports the scale-up and impact of nutrition-specific actions. Maternal education has long been linked to child survival, growth, and development while adult earnings and nutrition are tied to years in school as a child. However, less is known about the relationship between maternal education and the micronutrient status of children, women and the general population. Read More

    How will South Africa's mandatory salt reduction policy affect its salt iodisation programme? A cross-sectional analysis from the WHO-SAGE Wave 2 Salt & Tobacco study.
    BMJ Open 2018 Mar 30;8(3):e020404. Epub 2018 Mar 30.
    WHO Multi-Country Studies Unit, World Health Organization (WHO), Geneva, Switzerland.
    Objective: The WHO's global targets for non-communicable disease reduction recommend consumption of<5 g salt/day. In 2016, South Africa was the first country to legislate maximum salt levels in processed foods. South Africa's salt iodisation fortification programme has successfully addressed iodine deficiency but information is dated. Read More

    Stakeholders' Perceptions of Agronomic Iodine Biofortification: A SWOT-AHP Analysis in Northern Uganda.
    Nutrients 2018 Mar 24;10(4). Epub 2018 Mar 24.
    Department of Agricultural Economics, Ghent University, Coupure Links 653, 9000 Ghent, Belgium.
    Agronomic biofortification (i.e., the application of fertilizer to elevate micronutrient concentrations in staple crops) is a recent strategy recommended for controlling Iodine Deficiency Disorders (IDDs). Read More

    Pre-analytical Factors Influence Accuracy of Urine Spot Iodine Assessment in Epidemiological Surveys.
    Biol Trace Elem Res 2018 Mar 26. Epub 2018 Mar 26.
    INNTA (National Institute of Nutrition and Food Technology), SURVEN (Nutrition Surveillance and Epidemiology in Tunisia) Research Laboratory, 11 Rue Jebel Lakhdar, bab Saadoun, 1007, Tunis, Tunisia.
    Urinary iodine concentration (UIC) is commonly used to assess iodine status of subjects in epidemiological surveys. As pre-analytical factors are an important source of measurement error and studies about this phase are scarce, our objective was to assess the influence of urine sampling conditions on UIC, i.e. Read More

    Global epidemiology of hyperthyroidism and hypothyroidism.
    Nat Rev Endocrinol 2018 May 23;14(5):301-316. Epub 2018 Mar 23.
    Thyroid Research Group, Systems Immunity Research Institute, Cardiff University School of Medicine, Cardiff, UK.
    Thyroid hormones are essential for growth, neuronal development, reproduction and regulation of energy metabolism. Hypothyroidism and hyperthyroidism are common conditions with potentially devastating health consequences that affect all populations worldwide. Iodine nutrition is a key determinant of thyroid disease risk; however, other factors, such as ageing, smoking status, genetic susceptibility, ethnicity, endocrine disruptors and the advent of novel therapeutics, including immune checkpoint inhibitors, also influence thyroid disease epidemiology. Read More

    Heart failure, micronutrient profile, and its connection with thyroid dysfunction and nutritional status.
    Clin Nutr 2018 Mar 3. Epub 2018 Mar 3.
    Department of Internal Medicine, Medical School of Ribeirão Preto, Avenida Bandeirantes 3900, Monte Alegre, 14049-900 Ribeirão Preto, SP, Brazil.
    Introduction: Heart failure (HF) is a growing public health issue; its risk factors include inappropriate dietary intake of microelements such as iodine, selenium, zinc and iron, which may lead to thyroid dysfunction.

    Objective: This study aimed to assess the correlation among the functional class stages of patients with HF, iodine, selenium, iron and zinc levels with the presence of thyroid dysfunction.

    Methodology: One hundred nine patients from the HF outpatient clinic of the Clinics Hospital of Ribeirão Preto whose blood and urine were collected for micronutrient analysis and laboratory tests were selected. Read More

    High Urinary Iodine Concentration Among Breastfed Infants and the Factors Associated with Iodine Content in Breast Milk.
    Biol Trace Elem Res 2018 Mar 16. Epub 2018 Mar 16.
    Division of Nutrition, Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, 270 Rama VI Road, Ratchathewi, Bangkok, 10400, Thailand.
    Iodine deficiency in infants leads to delayed growth and development. Some studies have reported iodine deficiency among infants and lactating women. We assessed iodine status in infants and lactating women, as well as the iodine content in breast milk. Read More

    Thyroid Disease Around the World.
    Otolaryngol Clin North Am 2018 Mar 13. Epub 2018 Mar 13.
    Department of Head and Neck Surgery, Division of Surgery, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 1445, Houston, TX 77030, USA. Electronic address:
    Thyroid disease is one of the most common pathologies in the world, with two of the most clinically important subgroups being iodine deficiency and thyroid goiter, and thyroid cancer. This review looks at the current state of thyroid disease in the world and evaluates the future direction in terms of thyroid disease treatment and prevention. Several of the most impactful epidemiologic studies are presented and analyzed, as well as a brief overview of the current socioeconomic burden of disease. Read More

    Cow Milk Consumption Increases Iodine Status in Women of Childbearing Age in a Randomized Controlled Trial.
    J Nutr 2018 Mar;148(3):401-408
    Nutrition Innovation Centre for Food and Health (NICHE), School of Biomedical Sciences, Ulster University, Coleraine, County Londonderry, United Kingdom.
    Background: Recent evidence has highlighted the prevalence of mild-to-moderate iodine deficiency in women of childbearing age and pregnant women, with important public health ramifications due to the role of iodine, which is required for thyroid hormone production, in neurodevelopment. Cow milk contributes the greatest amount to iodine intakes in several countries.

    Objective: The objective of this study was to investigate the effect of increased cow milk consumption on iodine status, thyroid hormone concentrations, and selenium status. Read More

    A Comparison of Iodine Status in Children and Pregnant Women After a Policy Change in the Iodized Salt Standard in Shanghai, China.
    Biol Trace Elem Res 2018 Mar 14. Epub 2018 Mar 14.
    Institute of Iodine Deficiency Disorders Prevention and Control, Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin, Heilongjiang, China.
    In Shanghai, a new iodized salt standard was implemented in 2012. To provide evidence to the government, we compared iodine status before (35 mg/kg) and after (30 mg/kg) adjustment in vulnerable populations living in Shanghai. The probability-proportional-to-size sampling technique was used to select at least 360 pregnant women for urine iodine test and at least 1200 students for thyroid measurement and the household salt test. Read More

    Iodine deficiency in pregnancy: Still a health issue for the women of Cassino city, Italy.
    Nutrition 2017 Nov 27;50:60-65. Epub 2017 Nov 27.
    Department of Surgical Sciences, Sapienza University of Rome, Italy. Electronic address:
    Objective: The World Health Organization, the United Nations Children's Fund, and the International Council for the Control of Iodine Deficiency Disorders recommend a median urinary iodine concentration (UIC) in pregnant women between 150 µg/L and 249 µg/L. In the present study, we evaluated whether in the urban area of Cassino (central Italy), after a national salt iodination program (30 mg/kg) was introduced in 2005, the increased demand of iodine during pregnancy was satisfied.

    Methods: Between January 2016 and April 2017, 99 pregnant women were enrolled to evaluate UIC in spot urine samples, serum level of thyrotropin, free thyroxine, antithyroglobulin and antithyroperoxidase autoantibodies, and thyroid volume by ultrasonography. Read More

    Iodine Status among Somali Immigrants in Norway.
    Nutrients 2018 Mar 5;10(3). Epub 2018 Mar 5.
    Department of Community Medicine and Global Health, Institute of Health and Society, University of Oslo, Post Box 1130 Blindern, 0318 Oslo, Norway.
    We lack knowledge about iodine status in the Norwegian population in general, and particularly among immigrants. We aimed to estimate the iodine status and potentially associated factors in a Somali population in Norway. Somali men and women aged 20-73, who were living in one district in Oslo, were recruited between December 2015 and October 2016. Read More

    Optimizing Parkinson's disease diagnosis: the role of a dual nuclear imaging algorithm.
    NPJ Parkinsons Dis 2018 23;4. Epub 2018 Feb 23.
    Department of Neurology, Cedar-Sinai Medical Center, 127 S San Vicente Blvd, AHSP 6600, Los Angeles, CA 90272 USA.
    The diagnosis of Parkinson's disease (PD) currently relies almost exclusively on the clinical judgment of an experienced neurologist, ideally a specialist in movement disorders. However, such clinical diagnosis is often incorrect in a large percentage of patients, particularly in the early stages of the disease. A commercially available, objective and quantitative marker of nigrostriatal neurodegeneration was recently provided by 123-iodine I-ioflupane SPECT imaging, which is however unable to differentiate PD from a variety of other parkinsonian syndromes associated with striatal dopamine deficiency. Read More

    Is there any difference between the iodine statuses of breast-fed and formula-fed infants and their mothers in an area with iodine sufficiency?
    Br J Nutr 2018 May 5;119(9):1012-1018. Epub 2018 Mar 5.
    5Endocrine Research Center,Research Institute for Endocrine Sciences,Shahid Beheshti University of Medical Sciences,Tehran1985717413,Iran.
    Despite substantial progress in the global elimination of iodine deficiency, lactating mothers and their infants remain susceptible to insufficient iodine intake. This cross-sectional study was conducted to compare iodine statuses of breast-fed and formula-fed infants and their mothers at four randomly selected health care centres in Tehran. Healthy infants <3 months old and their mothers were randomly selected for inclusion in this study. Read More

    Experimental Simulation of the Effects of Essential and Toxic Trace Elements on Thyroid Function.
    Bull Exp Biol Med 2018 Mar 2;164(4):439-441. Epub 2018 Mar 2.
    Orenburg State University, Orenburg, Russia.
    The effects of essential (I, Se, and Zn) and toxic (Pb and Cd) trace elements on the thyroid function were studied experimentally. The protective effects of iodine, zinc, and selenium on thyroid tissue and antithyroid effects of toxic trace elements promoting a decrease in the levels of thyroid hormones (T, T) and imbalance of pituitary hormones (TSH) were detected. Addition of toxic trace elements to the ration of experimental rats led to their accumulation in the thyroid (0. Read More

    Hypothyroidism and Iodine Deficiency in Children on Chronic Parenteral Nutrition.
    Pediatrics 2018 Apr 1;141(4). Epub 2018 Mar 1.
    Divisions of Endocrinology.
    Background And Objectives: Iodine is an essential trace element for maintenance of normal thyroid function. Normal thyroid function is a prerequisite for neurocognitive development and growth in children. In the United States, iodine is not routinely added as a trace element in parenteral nutrition (PN). Read More

    Suboptimal Iodine Status among Pregnant Women in the Oslo Area, Norway.
    Nutrients 2018 Feb 28;10(3). Epub 2018 Feb 28.
    Division of Infection Control and Environmental Health, Norwegian Institute of Public Health, Oslo 0403, Norway.
    Norway has been considered iodine replete for decades; however, recent studies indicate reemergence of inadequate iodine status in different population groups. We assessed iodine status in pregnant women based on urinary iodine concentration (UIC), urinary iodine excretion (UIE), and iodine intake from food and supplements. In 804 pregnant women, 24-h iodine intakes from iodine-rich foods and iodine-containing supplements were calculated. Read More

    The Role of Insulin Resistance/Hyperinsulinism on the Rising Trend of Thyroid and Adrenal Nodular Disease in the Current Environment.
    J Clin Med 2018 Feb 26;7(3). Epub 2018 Feb 26.
    Department of Endocrinology, School of Health Sciences, University of Ioannina, 45110 Ioannina, Greece.
    Thyroid follicular cells, as well as adrenocortical cells, are endowed by an intrinsic heterogeneity regarding their growth potential, in response to various stimuli. This heterogeneity appears to constitute the underlying cause for the focal cell hyperplasia and eventually the formation of thyroid and adrenal nodules, under the influence of growth stimulatory factors. Among the main stimulatory factors are the pituitary tropic hormones, thyroid-stimulating hormone (TSH) or thyrotropin and adrenocorticotropic hormone (ACTH), which regulate the growth and function of their respective target cells, and the insulin/insulin-like growth factor system, that, through its mitogenic effects, can stimulate the proliferation of these cells. Read More

    Iodine Status during Pregnancy in a Region of Mild-to-Moderate Iodine Deficiency is not Associated with Adverse Obstetric Outcomes; Results from the Avon Longitudinal Study of Parents and Children (ALSPAC).
    Nutrients 2018 Mar 1;10(3). Epub 2018 Mar 1.
    Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, 1E Kent Ridge Road, Singapore 119228, Singapore.
    Severe iodine deficiency during pregnancy has been associated with pregnancy/neonatal loss, and adverse pregnancy outcomes; however, the impact of mild-to-moderate iodine insufficiency, though prevalent in pregnancy, is not well-documented. We assessed whether mild iodine deficiency during pregnancy was associated with pregnancy/infant loss, or with other adverse pregnancy outcomes. We used samples and data from the Avon Longitudinal Study of Parents and Children (ALSPAC), from 3140 singleton pregnancies and from a further 42 women with pregnancy/infant loss. Read More

    Iodine as Essential Nutrient during the First 1000 Days of Life.
    Nutrients 2018 Mar 1;10(3). Epub 2018 Mar 1.
    Department of Nutritional Sciences, Faculty of Health and Medical Sciences, University of Surrey, Guildford GU2 7XH, UK.
    Iodine is an essential micronutrient incorporated into thyroid hormones. Although iodine deficiency can lead to a broad spectrum of disorders throughout life, it is most critical in the early stages of development, as the foetal brain is extremely dependent on iodine supply. During the last two decades, our understanding of thyroid physiology during gestation has substantially improved. Read More

    Continuously sustained elimination of iodine deficiency: a quarter of a century success in the Islamic Republic of Iran.
    J Endocrinol Invest 2018 Feb 14. Epub 2018 Feb 14.
    Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Islamic Republic of Iran.
    Background: Iodine deficiency and related disorders were very common in Iran prior to 1996, when universal salt iodization (USI) was implemented and in 2000 Iran was declared iodine deficiency disorders (IDD) free. The aim of this study was to evaluate the adequacy of iodine intake by Iranian households in all 30 provinces of Iran, a quarter of a century after the intervention.

    Methods: A total of 18,000 school-aged children (8-10 years with mean 8. Read More

    Interaction between iodine and glucosinolates in rutabaga sprouts and selected biomarkers of thyroid function in male rats.
    J Trace Elem Med Biol 2018 Mar 15;46:110-116. Epub 2017 Dec 15.
    Department of Food Chemistry and Nutrition, Medical College, Jagiellonian University, Kraków, Poland. Electronic address:
    Rutabaga sprouts belong to the Brassicaceae family and may exert a negative influence on thyroid function, because they are a rich in glucosinolates. These sprouts are also valuable source of iodine (6.5 ± 0. Read More

    Breast milk is conditionally perfect.
    Med Hypotheses 2018 Feb 14;111:82-89. Epub 2017 Dec 14.
    Department of Nutrition, Brigham and Women's Hospital, Boston, MA 02115, USA. Electronic address:
    Breast milk is the universal preferred nutrition for the newborn human infant. New mother have been encouraged to exclusively breastfeed by health care professionals and consumer-advocacy forums for years, citing "breast milk is the perfect food". The benefits are numerous and include psychological, convenience, economical, ecological and nutritionally superior. Read More

    Dynamic Thiol/Disulphide Homeostasis in Children and Adolescents with Non-Autoimmune Subclinical Hypothyroidism.
    Med Princ Pract 2018 25;27(1):44-48. Epub 2018 Jan 25.
    Department of Biochemistry, Yıldırım Beyazıt University, School of Medicine, Ankara, Turkey.
    Objective: To evaluate the thiol/disulphide homeostasis in children with non-autoimmune subclinical hypothyroidism (SHT).

    Subjects And Methods: Thiol/disulphide homeosta sis, involving native thiol (SH), disulphide (SS), and total thiol (SS + SH), was evaluated in 60 children and adolescents who were negative for thyroid auto-antibodies (anti-thyroid peroxidase, anti-thyroglobulin) and had a thyroid-stimulating hormone (TSH) value of > 5 mIU/L, and in 40 sex- and age-matched healthy control subjects who were negative for thyroid autoantibodies and had normal TSH levels. Lipid profiles and urine iodine levels were also determined. Read More

    Do Statins Affect Thyroid Volume and Nodule Size in Patients with Hyperlipidemia in a Region with Mild-to-Moderate Iodine Deficiency? A Prospective Study.
    Med Princ Pract 2018 23;27(1):1-7. Epub 2018 Jan 23.
    Department of Endocrinology and Metabolism, Baskent University School of Medicine, Ankara, Turkey.
    Objective: The objective of this study was to assess the antiproliferative pleiotropic effects of statins on thyroid function, volume, and nodularity.

    Subjects And Methods: One hundred and six hyperlipidemic patients were included in this prospective study. The 69 patients in the statin groups received atorvastatin (16 received 10 mg and 18 received 20 mg) or rosuvastatin (20 received 10 mg and 15 received 20 mg). Read More

    Age- and gender-specific reference intervals of TSH and free T4 in an iodine-replete area: Data from Korean National Health and Nutrition Examination Survey IV (2013-2015).
    PLoS One 2018 1;13(2):e0190738. Epub 2018 Feb 1.
    Division of Endocrinology and Metabolism, Department of Medicine, Thyroid Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
    Background: Establishment of the reference interval of thyroid-stimulating hormone (TSH) is critical in the diagnosis of thyroid dysfunction and is affected by age, gender, iodine nutrition, and ethnicity. The aim of this study was to determine the reference intervals of TSH and free thyroxin (FT4) from a large, nationwide data of Korea where iodine intake is more than adequate.

    Methods: We analyzed data from the Korea National Health and Nutrition Examination Survey VI that measured serum TSH, FT4, and thyroid peroxidase antibody from 7,061 individuals (urinary iodine measurement in 6,565). Read More

    [Recent Trends of Trace Element Studies in Clinical Medicine in Japan].
    Nihon Eiseigaku Zasshi 2018 ;73(1):75-82
    Department of Health and Dietetics, Faculty of Health and Medical Sciences, Teikyo Heisei University.
    The deficiency or excess intake of trace elements, including zinc, copper, selenium and iodine, has often been reported. Zinc deficiency is often observed in infants fed breast milk with low zinc concentration, individuals administered chelating medicines, athletes and patients with diabetes mellitus, hepatic cirrhosis or nephrosis syndrome. Menkes disease is associated with severe copper deficiency, and there is no effective treatment. Read More

    Biomonitoring Equivalents for interpretation of urinary iodine.
    Regul Toxicol Pharmacol 2018 Apr 28;94:40-46. Epub 2018 Jan 28.
    Health Canada, Ottawa, ON, Canada.
    Iodine is an essential nutrient whose deficiency or excess exposure can cause adverse health effects. The primary sources of iodine exposure in the general population are iodized salt, dairy products, bread and sea food. Urinary iodine concentrations (UIC) have been measured by Canadian Health Measures Survey (CHMS) and US National Health and Nutrition Examination Survey (NHANES). Read More

    The bioaccessibility of iodine in the biofortified vegetables throughout cooking and simulated digestion.
    J Food Sci Technol 2018 Jan 27;55(1):366-375. Epub 2017 Nov 27.
    1Institute of Environment and Biogeochemistry, Zhejiang University, Hangzhou, 310027 China.
    Biofortification of crops with exogenous iodine is a novel strategy to control iodine deficiency disorders (IDD). The bioaccessibility of iodine (BI) in the biofortified vegetables in the course of soaking, cooking and digestion, were examined. Under hydroponics, the concentration of iodine in leafstalks of the celery and pakchoi increased with increasing exogenous iodine concentration, 54. Read More

    Disorders of metal metabolism.
    Transl Sci Rare Dis 2017 Dec 18;2(3-4):101-139. Epub 2017 Dec 18.
    Section on Human Biochemical Genetics, Medical Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, MD, USA.
    Trace elements are chemical elements needed in minute amounts for normal physiology. Some of the physiologically relevant trace elements include iodine, copper, iron, manganese, zinc, selenium, cobalt and molybdenum. Of these, some are metals, and in particular, transition metals. Read More

    Primordial and Primary Preventions of Thyroid Disease.
    Int J Endocrinol Metab 2017 Oct 7;15(4):e57871. Epub 2017 Oct 7.
    Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran.
    Background: Primordial and primary preventions of thyroid diseases are concerned with avoiding the appearance of risk factors, delaying the progression to overt disease, and minimizing the impact of illness.

    Summary: Using related key words, 446 articles related to primordial and primary, preventions of thyroid diseases published between 2001-2015 were evaluated, categorized and analyzed. Prevention and elimination of iodine deficiency are major steps that have been successfully achieved and maintained in many countries of the world in last 2 decades. Read More

    Development of Databases on Iodine in Foods and Dietary Supplements.
    Nutrients 2018 Jan 17;10(1). Epub 2018 Jan 17.
    Nutrient Data Laboratory, US Department of Agriculture, Beltsville, MD 20705, USA.
    Iodine is an essential micronutrient required for normal growth and neurodevelopment; thus, an adequate intake of iodine is particularly important for pregnant and lactating women, and throughout childhood. Low levels of iodine in the soil and groundwater are common in many parts of the world, often leading to diets that are low in iodine. Widespread salt iodization has eradicated severe iodine deficiency, but mild-to-moderate deficiency is still prevalent even in many developed countries. Read More

    Reference intervals for thyrotropin in an area of Northern Italy: the Pordenone thyroid study (TRIPP).
    J Endocrinol Invest 2018 Jan 16. Epub 2018 Jan 16.
    Endocrinology and Autoimmunity Laboratory, Department of Internal Medicine, IRCCS Azienda Ospedaliera Universitaria San Martino-IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy.
    Purpose: Thyrotropin (TSH) is the most accurate marker of thyroid dysfunction in the absence of pituitary or hypothalamic disease. Studies on TSH reference intervals (RIs) showed wide inter-individual variability and prompted an intense debate about the best estimation of TSH RIs.

    Design: We performed a population study on TSH RIs, using current data stored in the laboratory information system (LIS), at the Hospital Department of Laboratory Medicine, Pordenone (Italy), historically an area of mild-moderate iodine deficiency with a relatively high goiter prevalence. Read More

    Delayed conception in women with low-urinary iodine concentrations: a population-based prospective cohort study.
    Hum Reprod 2018 Jan 11. Epub 2018 Jan 11.
    Biostatistics and Bioinformatics Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, 6710B building, Bethesda, MD 20892, USA.
    Study Question: Is iodine deficiency associated with decreased fecundability?

    Summary Answer: Moderate to severe iodine deficiency is associated with a 46% decrease in fecundability.

    What Is Known Already: Iodine deficiency is common in women of childbearing age but its effect on fecundability has not been investigated.

    Study Design, Size, Duration: The LIFE Study, a population-based prospective cohort study, enrolled 501 women who had discontinued contraception within 2 months to become pregnant between 2005 and 2009. Read More

    Effects of Maternal Marginal Iodine Deficiency on Interactions between Cerebellar Bergmann Glia Cells and Purkinje Cells in Rat Offspring.
    Biomed Environ Sci 2017 Dec;30(12):932-937
    Department of Occupational and Environmental Health, School of Public Health, China Medical University, Shenyang 110112, Liaoning, China.
    Iodine deficiency (ID) during early pregnancy has an adverse effect on children's psychomotor and motor function but the mechanism has not been clarified. Therefore, our aim was to study the effect of maternal marginal ID on cerebellar neurodevelopment and the underlying mechanism. After obtaining marginal ID rats, we examined interactions between Bergmann glia cells (BGs) and Purkinje cells (PCs) using immunofluorescence and expression of the glutamate transporter and receptor by western blot. Read More

    Breast-Milk Iodine Concentrations and Iodine Levels of Infants According to the Iodine Status of the Country of Residence: A Systematic Review and Meta-Analysis.
    Thyroid 2018 Jan;28(1):124-138
    4 Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences , Tehran, Iran .
    Background: Iodine, an essential micronutrient, plays a critical role in normal growth and development, especially during the first two years of life. This systematic review and meta-analysis is among the first to evaluate breast-milk iodine concentrations and infant iodine status in countries characterized by iodine sufficiency or deficiency.

    Methods: PubMed, Web of Science, Cochrane Library, Google Scholar, and other relevant databases, as well as reference lists of previous reviews, were searched for relevant studies published between 1986 and 2016. Read More

    Less than total thyroidectomy for goiter: when and how?
    Gland Surg 2017 Dec;6(Suppl 1):S49-S58
    Division of Endocrine Surgery, Department of General Surgery, Ege University Hospital, Izmir, Turkey.
    Benign goiter is the most common endocrine disease that requires surgery, especially in endemic areas suffering from iodine-deficiency. Recent European and American guidelines recommended total thyroidectomy for the surgical treatment of multinodular goiter. Total thyroidectomy has now become the technique of choice and is widely considered the most reliable approach in preventing recurrence. Read More

    1 OF 114