10,443 results match your criteria Investigative ophthalmology & visual science[Journal]


JAK Inhibitors for Atopic Dermatitis: An Update.

Am J Clin Dermatol 2018 Dec 7. Epub 2018 Dec 7.

Department of Dermatology and the Immunology Institute, Icahn School of Medicine at Mount Sinai, 5 E. 98th Street, New York, NY, 10029, USA.

Atopic dermatitis (AD) is one of the most common inflammatory skin diseases. AD is driven by barrier dysfunction and abnormal immune activation of T helper (Th) 2, Th22, and varying degrees of Th1 and Th17 among various subtypes. The Janus kinase (JAK)-signal transducer and activator of transcription (STAT) and spleen tyrosine kinase (SYK) pathways are involved in signaling of several AD-related cytokines, such as IFN-γ, IL-4, IL-13, IL-31, IL-33, IL-23, IL-22, and IL-17, mediating downstream inflammation and barrier alterations. Read More

View Article
December 2018
1 Read

Digital Microscopy, Image Analysis, and Virtual Slide Repository.

ILAR J 2018 Dec 7. Epub 2018 Dec 7.

Famke Aeffner, DVM PhD DACVP, is a principal pathologist in the Comparative Biology and Safety Sciences Department at Amgen Inc. in South San Francisco, California. Hibret Adissu, DVM PhD DVSc DACVP, is an investigative pathologist in the Laboratory of Cancer Biology and Genetics, Center for Cancer Research, at the National Cancer Institute in Bethesda, Maryland. Michael C. Boyle, DVM PhD DACVP DABT, is a principal pathologist in the Comparative Biology and Safety Sciences at Amgen Inc. in Thousand Oaks, California. Robert D. Cardiff, MD PhD, is a distinguished professor of pathology (emeritus) at the Center for Comparative Medicine at the University of California in Davis, California. Erik Hagendorn is a senior scientist of informatics at AbbVie Bioresearch in Worcester, Massachusetts. Mark J. Hoenerhoff, DVM PhD DACVP, is an associate professor and veterinary pathologist at the In Vivo Animal Core, Unit for Laboratory Animal Medicine, at the University of Michigan in Ann Arbor, Michigan. Robert Klopfleisch, DVM PhD DACVP, is an associate professor at the Institute of Veterinary Pathology of the Freie Universitaet Berlin, in Berlin, Germany. Susan Newbigging, BSc MSc DVM DVSc, is a pathologist and Director of The Pathology Core at the Toronto Center of Phenogenomics in Toronto, Ontario, Canada. Dirk Schaudien, DVM PhD DACVP, is a veterinary pathologist at the Fraunhofer Institute for Toxicology and Experimental Medicine, in Hannover, Germany. Oliver Turner, BSC(Hons), BVSc MRCVS PhD DACVP DABT, is a senior pathologist in the Preclinical Safety department of Novartis Pharmaceuticals in East Hanover, New Jersey. Kristin Wilson, DVM PhD DACVP, is a pathologist at Flagship Biosciences Inc. in Westminster, Colorado.

Advancements in technology and digitization have ushered in novel ways of enhancing tissue-based research via digital microscopy and image analysis. Whole slide imaging scanners enable digitization of histology slides to be stored in virtual slide repositories and to be viewed via computers instead of microscopes. Easier and faster sharing of histologic images for teaching and consultation, improved storage and preservation of quality of stained slides, and annotation of features of interest in the digital slides are just a few of the advantages of this technology. Read More

View Article
December 2018

The Obv-Eas Method: An Easy Way to Facilitate Fiberoptic Intubation in Pediatric Patients: Case of an Infant with Freeman-Sheldon Syndrome.

Anesth Pain Med 2018 Oct 18;8(5):e81451. Epub 2018 Sep 18.

Orthopedics Surgery, Selcuk University Medical Faculty, Konya, Turkey.

View Article
October 2018

Somatosensory Plasticity in Pediatric Cerebral Palsy following Constraint-Induced Movement Therapy.

Neural Plast 2018 8;2018:1891978. Epub 2018 Nov 8.

Department of Hearing and Speech Sciences & Vanderbilt Kennedy Center, Vanderbilt University Medical Center, Nashville, TN, USA.

Cerebral palsy (CP) is predominantly a disorder of movement, with evidence of sensory-motor dysfunction. CIMT is a widely used treatment for hemiplegic CP. However, effects of CIMT on somatosensory processing remain unclear. Read More

View Article
November 2018

Unanticipated questions can yield unanticipated outcomes in investigative interviews.

PLoS One 2018 7;13(12):e0208751. Epub 2018 Dec 7.

Department of Psychology, University of Sussex, Brighton, East Sussex, United Kingdom.

Asking unanticipated questions in investigative interviews can elicit differences in the verbal behaviour of truth-tellers and liars: When faced with unanticipated questions, liars give less detailed and consistent responses than truth-tellers. Do such differences in verbal behaviour lead to an improvement in the accuracy of interviewers' veracity judgements? Two empirical studies evaluated the efficacy of the unanticipated questions technique. Experiment 1 compared two types of unanticipated questions (questions regarding the planning of a task and questions regarding the specific spatial and temporal details associated with the task), assessing the veracity judgements of interviewers and verbal content of interviewees' responses. Read More

View Article
December 2018

What Is Faith-Based Health Promotion? A Working Definition.

J Christ Nurs 2019 Jan/Mar;36(1):31-37

Chrysanthe Patestos, MSN, RN, is a lecturer at Kean University, Union, New Jersey, a faith community nurse, and active in youth ministry. Her research focus is faith-community involvement as a protective factor against initiation of substance use among youth.

Faith-based health promotion (FBHP) is a concept utilized across multiple disciplines, including nursing, public health, government, social work, and medicine. This article presents a hybrid concept analysis of FBHP and construction of a working definition for further investigative study. Defining FBHP is especially valuable for faith community nurses (FCNs), public health nurses, and other healthcare professionals who seek to study and offer FBHP. Read More

View Article
December 2018

Assessment of the potential investigative value of a decentralised rapid DNA workflow for reference DNA samples.

Forensic Sci Int 2018 Nov 26;294:140-149. Epub 2018 Nov 26.

National Institute of Forensic Science, Australia New Zealand Policing Advisory Agency, 637 Flinders Street, Docklands, 3008, Australia.

Rapid DNA technology has the ability to provide DNA analysis results in real-time. The purpose of this study was to assess the potential investigative value that could be gained by using a rapid DNA workflow in Australia, for reference DNA samples. A survey of police charging stations and DNA analysis laboratories in five Australian jurisdictions identified that a rapid DNA analysis workflow could have impacted the decision to release a person of interest from custody in 0. Read More

View Article
November 2018

Innate antimicrobial immunity in the skin: A protective barrier against bacteria, viruses, and fungi.

PLoS Pathog 2018 Dec 6;14(12):e1007353. Epub 2018 Dec 6.

Department of Dermatology, Duke University, Durham, North Carolina, United States of America.

View Article
December 2018
5 Reads

The appropriateness of coronary investigation in myocardial injury and type 2 myocardial infarction (ACT-2): A randomized trial design.

Am Heart J 2018 Oct 25;208:11-20. Epub 2018 Oct 25.

Department of Cardiology, Flinders Medical Centre, Adelaide, Australia; College of Medicine and Public Health, Flinders University of South Australia, Adelaide, Australia. Electronic address:

Background: Elevated troponin level findings among patients presenting with suspected acute coronary syndrome (ACS) or another intercurrent illness undeniably identifies patients at increased risk of mortality. Whilst enhancing our capacity to discriminate risk, the use of high-sensitivity troponin assays frequently identifies patients with myocardial injury (i.e. Read More

View Article
October 2018
4 Reads

Integrating Investigative Research into the Classroom: Foundational Experiences for Both Science Majors and Pre-Professional Healthcare Students.

J Allied Health 2018 ;47(4):300-307

Dep. of Health Sciences, Long Island University, Post, 720 Northern Boulevard, Brookville, NY 11548, USA. Tel 516-299-2691.

Few students at institutions that do not have scholarly research as central to their mission have the opportunity to explore experimental design and data analysis through investigative research. Laboratory courses are often the only opportunities to apply scientific knowledge, but traditionally rely on "cookbook" labs that often only demonstrate concepts. Much of the discussion regarding the need for research experiences in undergraduate education has focused on the impact on encouraging science students into research careers. Read More

View Article
January 2018

Distinct transcriptomic profiles of early-onset atopic dermatitis in blood and skin of pediatric patients.

Ann Allergy Asthma Immunol 2018 Nov 30. Epub 2018 Nov 30.

The Laboratory for Investigative Dermatology, The Rockefeller University, New York, NY, USA; Department of Dermatology, the Laboratory for Inflammatory Skin Diseases and the Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address:

View Article
November 2018

Central serous chorioretinopathy: Current update on management.

Oman J Ophthalmol 2018 Sep-Dec;11(3):200-206

Department of Vitreo-Retina Services, Aravind Eye Hospital and Postgraduate Institute of Ophthalmology, Coimbatore, Tamil Nadu, India.

Central serous chorioretinopathy (CSC), the fourth most common nonsurgical retinopathy with a usual self-limiting course, is known to present with persistent or recurrent form with distressing visual loss. Evolution of newer mutimodal imaging techniques have revolutionized the understanding about the pathophysiology of CSC, and hence the diagnosis and management. Multifactorial etiopathology of CSC promotes the use of multiple treatment modalities. Read More

View Article
December 2018

Doctors demand to see evidence on safety of medical devices approved in Europe.

Authors:
Simon Bowers

BMJ 2018 Nov 30;363:k5105. Epub 2018 Nov 30.

International Consortium of Investigative Journalists.

View Article
November 2018

Asymmetric Insular Connectomics Revealed by Diffusion Magnetic Resonance Imaging Analysis of Healthy Brain Development.

Brain Connect 2018 Dec 1. Epub 2018 Dec 1.

Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, United States.

The insula has been implicated in playing important roles in various brain functions including consciousness, homeostasis, perception, self-awareness, language processing, and interpersonal experience. Abnormalities of the insula have been observed in patients suffering from addiction, deteriorating language function, anorexia, and emotional dysregulation. We analyzed typical development of insular connections in a large-scale pediatric population using 642 magnetic resonance imaging (MRI) examinations. Read More

View Article
December 2018

Alternative Treatments for Atopic Dermatitis: An Update.

Am J Clin Dermatol 2018 Dec 3. Epub 2018 Dec 3.

Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

Atopic dermatitis (AD) is a chronic pruritic inflammatory skin disease in which management with topical anti-inflammatory agents during exacerbations remains the mainstay of treatment. With no cure in sight, a significant proportion of patients elect to incorporate complementary and alternative medicine (CAM) as an adjunct to conventional treatment. Many clinicians find it difficult to provide recommendations as the field covers an extensive number of very disparate therapies, with limited quality evidence to indicate efficacy. Read More

View Article
December 2018
2 Reads

From conceptual to computational: Cost and benefits of lizard thermoregulation revisited.

J Therm Biol 2018 Dec 20;78:174-183. Epub 2018 Sep 20.

Department of Biological Sciences, Sam Houston State University, Huntsville, TX, 77341, United States. Electronic address:

A classic paper detailed conceptual analyses of behavioral thermoregulation (Huey and Slatkin, 1976) and has served as the theoretical foundation for hundreds of investigative studies. Most recently, investigators have revisited this theoretical presentation to offer additional interpretation for both heterogeneity and spatial structure of temperature and how it may influence energetic costs (Sears and Angilletta, 2015). Interestingly, this foundational presentation by Huey and Slatkin, over 40 years ago, has never received formal computational analyses to address mathematically the postulates of this conceptual model. Read More

View Article
December 2018

Dear Editor.

Surg Obes Relat Dis 2018 Nov 7;14(11):1789-1790. Epub 2018 Sep 7.

Department of Upper Gastrointestinal and Bariatric Surgery, Musgrove Park Hospital, Taunton, United Kingdom.

View Article
November 2018

Polymorphisms in the anti-oxidant paraoxonase-1 (PON1) gene associated with fertility of postpartum dairy cows.

Theriogenology 2018 Nov 24;125:302-309. Epub 2018 Nov 24.

Department of Nutrition, College of Nutrition, Universidade Federal de Pelotas, Pelotas, RS, Brazil. Electronic address:

Paraoxonase 1 (PON1) is a negative acute phase plasma protein synthesized by the liver that has anti-oxidant activity. The aim of this study was to evaluate the association of single nucleotide polymorphisms (SNPs) in the PON1 promoter region with plasma PON1 activity and fertility in Holstein dairy cows. Sixty-eighty Holstein cows were used in this initial investigative study. Read More

View Article
November 2018

[Determining the age of the children from the cranial cranium vault fragments with the use of the modern investigative techniques].

Sud Med Ekspert 2018 ;61(6):13-16

Federal State Budgetary Institute 'Russian Centre of Forensic Medical Expertise', Ministry of Health of the Russia, Moscow, Russia, 125284.

The present study included 280 thin bone slices of the cranial vault fragments obtained from 70 children at the age of 2-3 weeks or above that and the subjects aged up to 21 years. The slices were prepared from the bone plates taken from the regions of the coronal (C - middle part), interparietal suture (S - apical and S - obelion parts), and occipital (L - middle part) sutures. The thickness of the cortical and spongy substances was measured with the use of an Olympus BX 51 microscope and an OlympusSC 30 digital camera supported by the ImageScope computer software - program. Read More

View Article
January 2018
3 Reads

Fatal combination of mitragynine and quetiapine - a case report with discussion of a potential herb-drug interaction.

Authors:
Rhome L Hughes

Forensic Sci Med Pathol 2018 Nov 29. Epub 2018 Nov 29.

University of North Dakota School of Medicine and Health Sciences, 1301 N. Columbia Rd (Room W430), Grand Forks, ND, 58203, USA.

Kratom is a plant with dose-dependent mixed stimulant and opioid properties whose pharmacologic characteristics and social impact continue to be described. The main active isolate of kratom is mitragynine, an indole-containing alkaloid with opioid-like effects. Kratom toxicity and kratom-associated fatalities have been described, including those in association with additional drugs. Read More

View Article
November 2018
2 Reads

Whistle blowing and Research Integrity: Potential Remedy for Research Misconduct in Malaysian Institution of Higher Education.

Account Res 2018 Nov 29. Epub 2018 Nov 29.

d Pusat Citra UKM, Universiti Kebangsaan Malaysia , 43600 Bangi , Selangor , Malaysia.

This study found that less than half of the respondents are willing to blow the whistle. The results reveal that a lack of protection with regard to the whistleblower's identity, the tedious investigative process, and the notion of avoiding confrontation, which is more apparent in Asian cultures as compared to the West, are among the reasons why individuals who witnessed misconduct chose to remain silent. Adhering to the Asian cultural upbringing where the young must respect the old, those of lower rank must obey those with higher authority, and subordinates do not question the actions of their superior, has become a norm even in the working environment. Read More

View Article
November 2018

A systematic review of randomised controlled trials investigating the efficacy and safety of testosterone therapy for female sexual dysfunction in postmenopausal women.

Clin Endocrinol (Oxf) 2018 Nov 29. Epub 2018 Nov 29.

Department of Investigative Medicine, Hammersmith Hospital, Imperial College London, London, UK.

The clinical sequelae of oestrogen deficiency during menopause are undoubted. However, the pathophysiological role of testosterone during the menopause is less clear. Several randomised, placebo-controlled clinical trials suggest that testosterone therapy improves sexual function in post-menopausal women. Read More

View Article
November 2018
2 Reads

Amplified fragment length polymorphism analysis supports the valid separate species status of and (Diptera: Calliphoridae).

Forensic Sci Res 2018 8;3(1):60-64. Epub 2017 Dec 8.

Department of Early Childhood Education, Faculty of Arts and Education, University of Stavanger, Stavanger, Norway.

Common DNA-based species determination methods fail to distinguish some blow flies in the forensically and medically important genus Robineau-Desvoidy. This is a practical problem, and it has also been interpreted as casting doubt on the validity of some morphologically defined species. An example is and , which co-occur in Europe whilst only has been collected in North America. Read More

View Article
December 2017

It Takes Two: The Round-Robin Methodology for Investigative Interviewing Research.

Front Psychol 2018 13;9:2181. Epub 2018 Nov 13.

Department of Psychology, University of Portsmouth, Portsmouth, United Kingdom.

Investigative interviews are complex, dyadic, and social interactions typically studied by evaluating interviewers' questioning strategies. In field settings, interviewers naturally vary in their interviewing practice. Thus, it is important to conduct research reflective of idiosyncrasies in witnesses, interviewers, and the resulting unique pairings. Read More

View Article
November 2018

Noninvasive allergic sinus congestion and resolution assessments using microcomputed tomography imaging.

J Appl Physiol (1985) 2018 Nov 30;125(5):1563-1575. Epub 2018 Aug 30.

Division of Pulmonary, Critical Care & Sleep Medicine, Department of Internal Medicine, University of Texas Medical Branch , Galveston, Texas.

Sinus congestion resultant of allergic rhinosinusitis is associated with development and worsening of asthma and can result in difficulty breathing, headaches, and missed days of school and work. Quantification of sinus congestion is important in the understanding of allergic rhinosinusitis and the development of new drugs for its treatment. Noninvasive microcomputed tomography (micro-CT) was investigated in a guinea pig model of allergic rhinosinusitis to determine its utility to determine accurately the degree of sinus congestion and resolution with anti-inflammatory drug administration. Read More

View Article
November 2018
2 Reads

Precision Medicine for Heritable Skin Diseases-The Paradigm of Epidermolysis Bullosa.

J Investig Dermatol Symp Proc 2018 Dec;19(2):S74-S76

Department of Dermatology and Cutaneous Biology, Sidney Kimmel Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

The 2016 JID Beijing Workshop, held in the context of the 5 National Congress of Investigative Dermatology of the Chinese Society of Dermatology, had the thematic focus on "Precision Medicine in Dermatology." This theme was extremely timely, yet forward-looking, due to the fact that precision medicine is one of the fastest growing paradigms of contemporary medicine (Box 1). Read More

View Article
December 2018

Open-source hardware designs for MRI of mice, rats, and marmosets: Integrated animal holders and radiofrequency coils.

J Neurosci Methods 2018 Nov 20;312:65-72. Epub 2018 Nov 20.

Centre for Functional and Metabolic Mapping, The University of Western Ontario, London, Ontario, Canada.

Background: Small-animal MRI is an important investigative tool for basic and preclinical research. High-resolution anatomical and functional studies of the brain require artifact-free images that are acquired with a highly sensitive radiofrequency (RF) coil.

New Method: The animal holder plays an important role in mitigating image artifacts: motion artifacts are reduced by immobilizing the animal and geometric-distortion artifacts are reduced by accurately positioning the animal to improve static-field shimming. Read More

View Article
November 2018
1 Read

Cracking the Combination: Gut Hormones for the Treatment of Obesity and Diabetes.

J Neuroendocrinol 2018 Nov 22:e12664. Epub 2018 Nov 22.

Section of Investigative Medicine, Imperial College London, 6th Floor, Commonwealth Building, Du Cane Road, London, W12 0HS.

Obesity and type 2 diabetes are a veritable global pandemic. There is an imperative to develop new therapies for these conditions that can be delivered at scale to patients, which deliver effective and titratable weight loss, amelioration of diabetes, prevention of diabetic complications and improvements in cardiovascular health. Although agents based on glucagon-like peptide-1 (GLP-1) are now in routine use for diabetes and obesity, the limited efficacy of such drugs means that newer agents are required. Read More

View Article
November 2018
7 Reads

Mixed connective tissue disease complicated by heart failure in Ile-Ife, Nigeria: management challenges in a resource-limited economy.

Int Med Case Rep J 2018 2;11:307-312. Epub 2018 Nov 2.

Department of Cardiology,

Background: Mixed connective tissue disease (MCTD; also known as Sharp's syndrome) is a rare autoimmune inflammatory disorder characterized by high titer of U1 ribonucleoprotein (U1RNP) antibody and clinical and serological overlap of systemic lupus erythematosus, systemic sclerosis, and polymyositis. The diagnosis is based on clinical and serological factors in criteria such as Alarcon-Segovia, Khan, Kusakawa, and Sharps. Cardiac disease can be a complication of connective tissue disease (CTD). Read More

View Article
November 2018
5 Reads

Coronary heart disease mortality in severe vs. non-severe familial hypercholesterolaemia in the Simon Broome Register.

Atherosclerosis 2018 Nov 12. Epub 2018 Nov 12.

Wolfson College, University of Oxford, Oxford, UK.

Background And Aims: The International Atherosclerosis Society (IAS) has proposed that patients with "severe" FH (SFH) would warrant early and more aggressive cholesterol-lowering treatment such as with PCSK9 inhibitors. SFH is diagnosed if LDL-cholesterol (LDLC) > 10 mmol/L, or LDLC >8.0 mmol/L plus one high-risk feature, or LDLC >5 mmol/L plus two high-risk features. Read More

View Article
November 2018
4 Reads

Combined RNA-seq and RAT-seq mapping of long noncoding RNAs in pluripotent reprogramming.

Sci Data 2018 Nov 20;5:180255. Epub 2018 Nov 20.

Stem Cell and Cancer Center, First Hospital, Jilin University, Changchun, Jilin 130061, P.R. China.

Pluripotent stem cells hold great investigative potential for developmental biology and regenerative medicine. Recent studies suggest that long noncoding RNAs (lncRNAs) may function as key regulators of the maintenance and the lineage differentiation of stem cells. However, the underlying mechanisms by which lncRNAs affect the reprogramming process of somatic cells into pluripotent cells remain largely unknown. Read More

View Article
November 2018
8 Reads

Outbreak of scurvy in Tana River County, Kenya: A case report.

Afr J Prim Health Care Fam Med 2018 Oct 25;10(1):e1-e3. Epub 2018 Oct 25.

Family Medicine Department, Africa Inland Church, Kijabe Hospital.

Over a five-month period, clinicians in Tana River County Kenya observed an increasing number of patients presenting to health facilities with a common collection of symptoms including fevers, joint pains and gum hypertrophy. After initial investigative and management strategies failed to reveal a diagnosis, patients were empirically commenced on ascorbic acid for presumed scurvy. This strategy resulted in the rapid resolution of symptoms in 65 patients within two weeks. Read More

View Article
October 2018
2 Reads

RATEmiRs: the rat atlas of tissue-specific and enriched miRNAs database.

BMC Genomics 2018 Nov 19;19(1):825. Epub 2018 Nov 19.

Microarray and Genome Informatics Group, National Institute of Environmental Health Sciences, P.O. Box 12233, Research Triangle Park, NC, 27709, USA.

Background: MicroRNAs (miRNAs) regulate gene expression and have been targeted as indicators of environmental/toxicologic stressors. Using the data from our deep sequencing of miRNAs in an extensive sampling of rat tissues, we developed a database called RATEmiRs for the Rat Atlas of Tissue-specific and Enriched miRNAs to allow users to dynamically determine mature-, iso- and pre-miR expression abundance, enrichment and specificity in rat tissues and organs.

Results: Illumina sequencing count data from mapped reads and meta data from the miRNA body atlas consisting of 21 and 23 tissues (14 organs) of toxicologic interest from 12 to 13 week old male and female Sprague Dawley rats respectively, were managed in a relational database with a user-friendly query interface. Read More

View Article
November 2018
4 Reads

In situ Study Unravels Bio-Nanomechanical Behavior in a Magnetic Bacterial Nano-cellulose (MBNC) Hydrogel for Neuro-Endovascular Reconstruction.

Macromol Biosci 2018 Nov 19:e1800225. Epub 2018 Nov 19.

School of Aeronautics and Astronautics, Purdue University, West Lafayette, IN, 47907, USA.

Surgical clipping and endovascular coiling are well recognized as conventional treatments of Penetrating Brain Injury aneurysms. These clinical approaches show partial success, but often result in thrombus formation and the rupture of aneurysm near arterial walls. The authors address these challenging brain traumas with a unique combination of a highly biocompatible biopolymer hydrogel rendered magnetic in a flexible and resilient membrane coating integrated to a scaffold stent platform at the aneurysm neck orifice, which enhances the revascularization modality. Read More

View Article
November 2018
4 Reads

Silencing of ADAM33 restrains proliferation and induces apoptosis of airway smooth muscle cells in ovalbumin-induced asthma model.

J Cell Biochem 2018 Nov 18. Epub 2018 Nov 18.

Department of Respiratory Medicine, the First Affiliated Hospital of Nanchang University, Nanchang, China.

A defibrinogen and metalloproteinase 33 (ADAM33) was reported to play an important role in asthma. Furthermore, ADAM33 may play a possible role in airway remodeling due to its high expression in myo-/fibroblasts, epithelium, as well as the airway smooth muscle cells (ASMCs). Thus, the study is supposed to investigate the effect of the downregulation of ADAM33 on the proliferation and apoptosis of ASMCs in allergic asthma. Read More

View Article
November 2018
1 Read

Estimating the postmortem interval using microbes: Knowledge gaps and a path to technology adoption.

Forensic Sci Int Genet 2019 Jan 8;38:211-218. Epub 2018 Nov 8.

Department of Animal Sciences, Colorado State University, Fort Collins, CO 80525, USA. Electronic address:

Microbes have potential to be used as physical evidence for forensic science because they are ubiquitous and have predictable ecologies. With the advent of next generation sequencing technology and the subsequent boost to microbiome science (study of the genes and molecules of microbial communities), it has become possible to develop new microbial-based tools for forensic science. One promising approach is the use of microbial succession during the ecological process of decomposition to estimate the time since death, or postmortem interval (PMI). Read More

View Article
January 2019
6 Reads

Applying Artificial Intelligence to Address the Knowledge Gaps in Cancer Care.

Oncologist 2018 Nov 16. Epub 2018 Nov 16.

Department of Genomic Medicine, MD Anderson Cancer Center, Houston, Texas, USA

Background: Rapid advances in science challenge the timely adoption of evidence-based care in community settings. To bridge the gap between what is possible and what is practiced, we researched approaches to developing an artificial intelligence (AI) application that can provide real-time patient-specific decision support.

Materials And Methods: The Oncology Expert Advisor (OEA) was designed to simulate peer-to-peer consultation with three core functions: patient history summarization, treatment options recommendation, and management advisory. Read More

View Article
November 2018

From unknown to known: Identification of the remains at the mausoleum of fosse Ardeatine.

Sci Justice 2018 Nov 24;58(6):469-478. Epub 2018 May 24.

Department of Biology, University of Florence, Laboratory of Anthropology -Molecular Anthropology and Forensic Unit, Firenze, Italy.

During the Second World War, on 24th March 1944, 335 Italians were massacred near Rome by the occupying forces of Nazi Germany. Four months later forensic examination led to the identification of 323 out of 335 victims. After approximately 60 years, the identification of the remaining unidentified twelve victims began with anthropological and genetic analysis carried out by a team of Italian forensic experts. Read More

View Article
November 2018

Knowledge, attitudes and practices related to stroke in Ghana and Nigeria: A SIREN call to action.

PLoS One 2018 16;13(11):e0206548. Epub 2018 Nov 16.

University College Hospital and University of Ibadan, Ibadan, Nigeria.

Introduction: Stroke is a prominent cause of death, disability, and dementia in sub-Saharan Africa (SSA). The Stroke Investigative Research and Education Network works collaboratively with stroke survivors and individuals serving as community controls to comprehensively characterize the genomic, sociocultural, economic and behavioral risk factors for stroke in SSA.

Purpose: In this paper, we aim to: i) explore the attitudes, beliefs, and practices related to stroke in Ghana and Nigeria using the process of qualitative description; and ii) propose actions for future research and community-based participation and education. Read More

View Article
November 2018
11 Reads
3.230 Impact Factor

Perioperative Hypertensive Urgency After Methylene Blue in a Patient With Undiagnosed Pheochromocytoma: A Case Report.

A A Pract 2018 Nov 12. Epub 2018 Nov 12.

From the Department of Anesthesiology, Yale University School of Medicine, New Haven, Connecticut.

We report the perioperative course of a 75-year-old woman undergoing robotic-assisted laparoscopic hysterectomy and tumor debulking. The patient developed severe, persistent hypertension after intraoperative methylene blue administration requiring a Surgical Intensive Care Unit admission with further investigative evaluation revealing a previously undiagnosed pheochromocytoma. Our discussion focuses on the differential diagnoses for her perioperative hypertension. Read More

View Article
November 2018
1 Read

The Quality of Reporting Randomised Controlled Trials in the Dermatology Literature in an Era where the CONSORT Statement is a Standard.

Br J Dermatol 2018 Nov 15. Epub 2018 Nov 15.

Department of Dermatology, SMG-SNU Boramae Medical Center, Seoul, Korea.

Background: The quality of reporting randomised controlled trials (RCTs) in the dermatology literature has not received much consideration since the late 2000s.

Objectives: We aimed to assess the quality of recently reported RCTs published in dermatology journals, focusing on randomisation processes, blinding, and trial registration.

Methods: We reviewed 2,042 original articles and identified 141 primary reports of RCTs in four dermatology journals (The Journal of the American Academy of Dermatology, JAMA Dermatology, The Journal of Investigative Dermatology, and The British Journal of Dermatology) from January 2015 to December 2017. Read More

View Article
November 2018
5 Reads

Clinical and Investigative Endocrinology and Diabetes.

Authors:

Endocr Pract 2018 Oct;24(s2):1-22

View Article
October 2018

Surgical Biopsy of Pathologically Enlarged Lymph Nodes: A Reappraisal.

Isr Med Assoc J 2018 Nov;20(11):674-678

Division of General Surgery, Rambam Health Care Campus, affiliated with Rappaport Faculty of Medicine, Technion-lsrael Institute of Technology, Haifa, Israel.

Background: Enlarged lymph nodes (ELN) pose a great diagnostic challenge. They may represent the first clinical finding of a hematologic disease or other malignancy and may be an indication of a wide range of infectious and non-infectious diseases. Because many patients undergo percutaneous biopsy, surgical excisional biopsy is not often considered. Read More

View Article
November 2018

Complement, Hidradenitis Suppurativa and Pathogen-Driven Positive Selection.

Authors:
J W Frew

Br J Dermatol 2018 Nov 15. Epub 2018 Nov 15.

Laboratory of Investigative Dermatology, The Rockefeller University, New York, USA.

The precise pathogenesis of Hidradenitis Suppurativa (HS) remains unclear. Kanni et al provides novel data implicating C5a and the membrane attack complex in HS pathogenesis. This opens the possibility of therapeutic blockade of C5a for the treatment of HS, although the results do require replication in larger patient cohorts. Read More

View Article
November 2018
3 Reads

Investigative Study on Nitric Oxide Production in Human Dermal Fibroblast Cells under Normal and High Glucose Conditions.

Med Sci (Basel) 2018 Nov 9;6(4). Epub 2018 Nov 9.

Department of Biomedical Engineering, Michigan Technological University, Houghton, MI 49931, USA.

Diabetic foot ulcers (DFU) are a major health problem associated with diabetes mellitus. Impaired nitric oxide (NO) production has been shown to be a major contributor to the dysregulation of healing in DFU. The level of impairment is not known primarily due to challenges with measuring NO. Read More

View Article
November 2018
4 Reads

Inter- and Intra-Host Nucleotide Variations in Hepatitis A Virus in Culture and Clinical Samples Detected by Next-Generation Sequencing.

Viruses 2018 Nov 9;10(11). Epub 2018 Nov 9.

Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, Laurel, MD 20708, USA.

The accurate virus detection, strain discrimination, and source attribution of contaminated food items remains a persistent challenge because of the high mutation rates anticipated to occur in foodborne RNA viruses, such as hepatitis A virus (HAV). This has led to predictions of the existence of more than one sequence variant between the hosts (inter-host) or within an individual host (intra-host). However, there have been no reports of intra-host variants from an infected single individual, and little is known about the accuracy of the single nucleotide variations (SNVs) calling with various methods. Read More

View Article
November 2018
4 Reads

Bariatric Surgery Does Not Affect Food Preferences, but Individual Changes in Food Preferences May Predict Weight Loss.

Obesity (Silver Spring) 2018 Dec 13;26(12):1879-1887. Epub 2018 Nov 13.

Department of Nutrition, Exercise and Sports, Faculty of Science (Obesity Research), University of Copenhagen, Copenhagen, Denmark.

Objective: Using an ad libitum buffet meal targeting direct behavior, the authors of the current study previously reported no effect of Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) surgery on food preferences 6 months after surgery. The current study investigated changes in food preferences at 18 months after surgery and whether changes in food preferences at 6 months predicted weight loss.

Methods: Twenty food items separated into the following food categories were served at the buffet meal: high-fat, low-fat, sweet, savory, high-fat savory, high-fat sweet, low-fat savory, and low-fat sweet. Read More

View Article
December 2018
2 Reads

[Structured interviewing of children in suspected child endangerment cases: The German version of the revised NICHD Investigative Interview Protocol].

Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 2018 Dec;61(12):1587-1602

Zentrum für Kinderheilkunde, Universität Bonn, Bonn, Deutschland.

Interviewing a child of a suspected abuse (physical abuse, sexual abuse, neglect, Munchausen-by-proxy syndrome) is subject to complex risks of suggestion and distortion. The use of a standardized interview protocol as part of the investigation can significantly increase the scope and validity of the child's report in different settings (for example, pediatrics, child welfare services, court).In this paper, the interview protocol provided by the National Institute of Child Health and Human Development (NICHD) in its revised and complete version is presented in German and made available for free clinical use in the Appendix. Read More

View Article
December 2018
1 Read

[Interviewing children in cases of suspected child endangerment: pitfalls and quality assurance].

Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 2018 Dec;61(12):1579-1586

Zentrum für Kinderheilkunde, Universität Bonn, Bonn, Deutschland.

Doctors and especially paediatricians in clinics and private practices are often the first professionals to be confronted with the suspicion of a child endangerment (sexual abuse, physical abuse, neglect, Munchausen-by-proxy syndrome). They thus play a key role in the early assessment and clarification of suspicion and setting the course for the further interdisciplinary procedure.The clinical investigation of a suspicion is a diagnostic and communicative challenge. Read More

View Article
December 2018
2 Reads