1,737 results match your criteria Investigative ophthalmology & visual science[Journal]


Electroencephalography.

Curr Biol 2019 Feb;29(3):R80-R85

The Laboratory for Investigative Neurophysiology (The LINE), Department of Radiology, University Hospital Center and University of Lausanne (CHUV), Lausanne, Switzerland; Ophthalmology Department, University of Lausanne, Fondation Asile des Aveugles, Lausanne, Switzerland; EEG Brain Mapping Core, Center for Biomedical Imaging (CIBM) of Lausanne and Geneva, Lausanne, Switzerland; Department of Hearing and Speech Sciences, Vanderbilt University Medical Center, Nashville, TN 37232, USA. Electronic address:

Electroencephalography (EEG) is the non-invasive measurement of the brain's electric fields. Electrodes placed on the scalp record voltage potentials resulting from current flow in and around neurons. EEG is nearly a century old: this long history has afforded EEG a rich and diverse spectrum of applications. Read More

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http://dx.doi.org/10.1016/j.cub.2018.11.052DOI Listing
February 2019

The interplay between prematurity, maternal stress and children's intelligence quotient at age 11: A longitudinal study.

Sci Rep 2019 Jan 24;9(1):450. Epub 2019 Jan 24.

University Service of Child and Adolescent Psychiatry, University Hospital of Lausanne, Lausanne, Switzerland.

Very premature children (<33 weeks of gestational age (GA)) experience greater academic difficulties and have lower, though normal-range, intelligence quotients (IQs) versus their full-term peers. These differences are often attributed to GA or familial socio-economic status (SES). However, additional factors are increasingly recognized as likely contributors. Read More

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http://dx.doi.org/10.1038/s41598-018-36465-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345959PMC
January 2019
2 Reads

Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines.

Authors:
Clotilde Théry Kenneth W Witwer Elena Aikawa Maria Jose Alcaraz Johnathon D Anderson Ramaroson Andriantsitohaina Anna Antoniou Tanina Arab Fabienne Archer Georgia K Atkin-Smith D Craig Ayre Jean-Marie Bach Daniel Bachurski Hossein Baharvand Leonora Balaj Shawn Baldacchino Natalie N Bauer Amy A Baxter Mary Bebawy Carla Beckham Apolonija Bedina Zavec Abderrahim Benmoussa Anna C Berardi Paolo Bergese Ewa Bielska Cherie Blenkiron Sylwia Bobis-Wozowicz Eric Boilard Wilfrid Boireau Antonella Bongiovanni Francesc E Borràs Steffi Bosch Chantal M Boulanger Xandra Breakefield Andrew M Breglio Meadhbh Á Brennan David R Brigstock Alain Brisson Marike Ld Broekman Jacqueline F Bromberg Paulina Bryl-Górecka Shilpa Buch Amy H Buck Dylan Burger Sara Busatto Dominik Buschmann Benedetta Bussolati Edit I Buzás James Bryan Byrd Giovanni Camussi David Rf Carter Sarah Caruso Lawrence W Chamley Yu-Ting Chang Chihchen Chen Shuai Chen Lesley Cheng Andrew R Chin Aled Clayton Stefano P Clerici Alex Cocks Emanuele Cocucci Robert J Coffey Anabela Cordeiro-da-Silva Yvonne Couch Frank Aw Coumans Beth Coyle Rossella Crescitelli Miria Ferreira Criado Crislyn D'Souza-Schorey Saumya Das Amrita Datta Chaudhuri Paola de Candia Eliezer F De Santana Olivier De Wever Hernando A Del Portillo Tanguy Demaret Sarah Deville Andrew Devitt Bert Dhondt Dolores Di Vizio Lothar C Dieterich Vincenza Dolo Ana Paula Dominguez Rubio Massimo Dominici Mauricio R Dourado Tom Ap Driedonks Filipe V Duarte Heather M Duncan Ramon M Eichenberger Karin Ekström Samir El Andaloussi Celine Elie-Caille Uta Erdbrügger Juan M Falcón-Pérez Farah Fatima Jason E Fish Miguel Flores-Bellver András Försönits Annie Frelet-Barrand Fabia Fricke Gregor Fuhrmann Susanne Gabrielsson Ana Gámez-Valero Chris Gardiner Kathrin Gärtner Raphael Gaudin Yong Song Gho Bernd Giebel Caroline Gilbert Mario Gimona Ilaria Giusti Deborah Ci Goberdhan André Görgens Sharon M Gorski David W Greening Julia Christina Gross Alice Gualerzi Gopal N Gupta Dakota Gustafson Aase Handberg Reka A Haraszti Paul Harrison Hargita Hegyesi An Hendrix Andrew F Hill Fred H Hochberg Karl F Hoffmann Beth Holder Harry Holthofer Baharak Hosseinkhani Guoku Hu Yiyao Huang Veronica Huber Stuart Hunt Ahmed Gamal-Eldin Ibrahim Tsuneya Ikezu Jameel M Inal Mustafa Isin Alena Ivanova Hannah K Jackson Soren Jacobsen Steven M Jay Muthuvel Jayachandran Guido Jenster Lanzhou Jiang Suzanne M Johnson Jennifer C Jones Ambrose Jong Tijana Jovanovic-Talisman Stephanie Jung Raghu Kalluri Shin-Ichi Kano Sukhbir Kaur Yumi Kawamura Evan T Keller Delaram Khamari Elena Khomyakova Anastasia Khvorova Peter Kierulf Kwang Pyo Kim Thomas Kislinger Mikael Klingeborn David J Klinke Miroslaw Kornek Maja M Kosanović Árpád Ferenc Kovács Eva-Maria Krämer-Albers Susanne Krasemann Mirja Krause Igor V Kurochkin Gina D Kusuma Sören Kuypers Saara Laitinen Scott M Langevin Lucia R Languino Joanne Lannigan Cecilia Lässer Louise C Laurent Gregory Lavieu Elisa Lázaro-Ibáñez Soazig Le Lay Myung-Shin Lee Yi Xin Fiona Lee Debora S Lemos Metka Lenassi Aleksandra Leszczynska Isaac Ts Li Ke Liao Sten F Libregts Erzsebet Ligeti Rebecca Lim Sai Kiang Lim Aija Linē Karen Linnemannstöns Alicia Llorente Catherine A Lombard Magdalena J Lorenowicz Ákos M Lörincz Jan Lötvall Jason Lovett Michelle C Lowry Xavier Loyer Quan Lu Barbara Lukomska Taral R Lunavat Sybren Ln Maas Harmeet Malhi Antonio Marcilla Jacopo Mariani Javier Mariscal Elena S Martens-Uzunova Lorena Martin-Jaular M Carmen Martinez Vilma Regina Martins Mathilde Mathieu Suresh Mathivanan Marco Maugeri Lynda K McGinnis Mark J McVey David G Meckes Katie L Meehan Inge Mertens Valentina R Minciacchi Andreas Möller Malene Møller Jørgensen Aizea Morales-Kastresana Jess Morhayim François Mullier Maurizio Muraca Luca Musante Veronika Mussack Dillon C Muth Kathryn H Myburgh Tanbir Najrana Muhammad Nawaz Irina Nazarenko Peter Nejsum Christian Neri Tommaso Neri Rienk Nieuwland Leonardo Nimrichter John P Nolan Esther Nm Nolte-'t Hoen Nicole Noren Hooten Lorraine O'Driscoll Tina O'Grady Ana O'Loghlen Takahiro Ochiya Martin Olivier Alberto Ortiz Luis A Ortiz Xabier Osteikoetxea Ole Østergaard Matias Ostrowski Jaesung Park D Michiel Pegtel Hector Peinado Francesca Perut Michael W Pfaffl Donald G Phinney Bartijn Ch Pieters Ryan C Pink David S Pisetsky Elke Pogge von Strandmann Iva Polakovicova Ivan Kh Poon Bonita H Powell Ilaria Prada Lynn Pulliam Peter Quesenberry Annalisa Radeghieri Robert L Raffai Stefania Raimondo Janusz Rak Marcel I Ramirez Graça Raposo Morsi S Rayyan Neta Regev-Rudzki Franz L Ricklefs Paul D Robbins David D Roberts Silvia C Rodrigues Eva Rohde Sophie Rome Kasper Ma Rouschop Aurelia Rughetti Ashley E Russell Paula Saá Susmita Sahoo Edison Salas-Huenuleo Catherine Sánchez Julie A Saugstad Meike J Saul Raymond M Schiffelers Raphael Schneider Tine Hiorth Schøyen Aaron Scott Eriomina Shahaj Shivani Sharma Olga Shatnyeva Faezeh Shekari Ganesh Vilas Shelke Ashok K Shetty Kiyotaka Shiba Pia R-M Siljander Andreia M Silva Agata Skowronek Orman L Snyder Rodrigo Pedro Soares Barbara W Sódar Carolina Soekmadji Javier Sotillo Philip D Stahl Willem Stoorvogel Shannon L Stott Erwin F Strasser Simon Swift Hidetoshi Tahara Muneesh Tewari Kate Timms Swasti Tiwari Rochelle Tixeira Mercedes Tkach Wei Seong Toh Richard Tomasini Ana Claudia Torrecilhas Juan Pablo Tosar Vasilis Toxavidis Lorena Urbanelli Pieter Vader Bas Wm van Balkom Susanne G van der Grein Jan Van Deun Martijn Jc van Herwijnen Kendall Van Keuren-Jensen Guillaume van Niel Martin E van Royen Andre J van Wijnen M Helena Vasconcelos Ivan J Vechetti Tiago D Veit Laura J Vella Émilie Velot Frederik J Verweij Beate Vestad Jose L Viñas Tamás Visnovitz Krisztina V Vukman Jessica Wahlgren Dionysios C Watson Marca Hm Wauben Alissa Weaver Jason P Webber Viktoria Weber Ann M Wehman Daniel J Weiss Joshua A Welsh Sebastian Wendt Asa M Wheelock Zoltán Wiener Leonie Witte Joy Wolfram Angeliki Xagorari Patricia Xander Jing Xu Xiaomei Yan María Yáñez-Mó Hang Yin Yuana Yuana Valentina Zappulli Jana Zarubova Vytautas Žėkas Jian-Ye Zhang Zezhou Zhao Lei Zheng Alexander R Zheutlin Antje M Zickler Pascale Zimmermann Angela M Zivkovic Davide Zocco Ewa K Zuba-Surma

J Extracell Vesicles 2018 23;7(1):1535750. Epub 2018 Nov 23.

Jagiellonian University, Faculty of Biochemistry, Biophysics and Biotechnology, Department of Cell Biology, Kraków, Poland.

The last decade has seen a sharp increase in the number of scientific publications describing physiological and pathological functions of extracellular vesicles (EVs), a collective term covering various subtypes of cell-released, membranous structures, called exosomes, microvesicles, microparticles, ectosomes, oncosomes, apoptotic bodies, and many other names. However, specific issues arise when working with these entities, whose size and amount often make them difficult to obtain as relatively pure preparations, and to characterize properly. The International Society for Extracellular Vesicles (ISEV) proposed Minimal Information for Studies of Extracellular Vesicles ("MISEV") guidelines for the field in 2014. Read More

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https://www.tandfonline.com/doi/full/10.1080/20013078.2018.1
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http://dx.doi.org/10.1080/20013078.2018.1535750DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322352PMC
November 2018
32 Reads

Applications of Raman spectroscopy in cancer diagnosis.

Cancer Metastasis Rev 2018 Dec;37(4):691-717

Michael and Marian Ilitch Department of Surgery, School of Medicine, Wayne State University, 5050 Anthony Wayne Drive, Detroit, MI, 48202, USA.

Novel approaches toward understanding the evolution of disease can lead to the discovery of biomarkers that will enable better management of disease progression and improve prognostic evaluation. Raman spectroscopy is a promising investigative and diagnostic tool that can assist in uncovering the molecular basis of disease and provide objective, quantifiable molecular information for diagnosis and treatment evaluation. This technique probes molecular vibrations/rotations associated with chemical bonds in a sample to obtain information on molecular structure, composition, and intermolecular interactions. Read More

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http://link.springer.com/10.1007/s10555-018-9770-9
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http://dx.doi.org/10.1007/s10555-018-9770-9DOI Listing
December 2018
7 Reads

Somatosensory Plasticity in Pediatric Cerebral Palsy following Constraint-Induced Movement Therapy.

Neural Plast 2018 8;2018:1891978. Epub 2018 Nov 8.

Department of Hearing and Speech Sciences & Vanderbilt Kennedy Center, Vanderbilt University Medical Center, Nashville, TN, USA.

Cerebral palsy (CP) is predominantly a disorder of movement, with evidence of sensory-motor dysfunction. CIMT is a widely used treatment for hemiplegic CP. However, effects of CIMT on somatosensory processing remain unclear. Read More

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https://www.hindawi.com/journals/np/2018/1891978/
Publisher Site
http://dx.doi.org/10.1155/2018/1891978DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6250030PMC
January 2019
7 Reads

Central serous chorioretinopathy: Current update on management.

Oman J Ophthalmol 2018 Sep-Dec;11(3):200-206

Department of Vitreo-Retina Services, Aravind Eye Hospital and Postgraduate Institute of Ophthalmology, Coimbatore, Tamil Nadu, India.

Central serous chorioretinopathy (CSC), the fourth most common nonsurgical retinopathy with a usual self-limiting course, is known to present with persistent or recurrent form with distressing visual loss. Evolution of newer mutimodal imaging techniques have revolutionized the understanding about the pathophysiology of CSC, and hence the diagnosis and management. Multifactorial etiopathology of CSC promotes the use of multiple treatment modalities. Read More

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http://dx.doi.org/10.4103/ojo.OJO_29_2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219318PMC
December 2018
1 Read

The diagnostic value of optical coherence tomography angiography in diabetic retinopathy: a systematic review.

Authors:
David Gildea

Int Ophthalmol 2018 Oct 31. Epub 2018 Oct 31.

UCL Institute of Ophthalmology, 11-43 Bath St, London, EC1V 9EL, UK.

Purpose: Diabetic retinopathy (DR) is one of the leading causes of blindness worldwide. Accurate investigative tools are essential for the early diagnosis and monitoring of the disease. Optical coherence tomography angiography (OCTA) is a recently developed technology that enables visualisation of the retinal microvasculature. Read More

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http://dx.doi.org/10.1007/s10792-018-1034-8DOI Listing
October 2018
1 Read

Visual field plasticity in hearing users of sign language.

Vision Res 2018 12 30;153:105-110. Epub 2018 Aug 30.

Department of Ophthalmology, Centre Hospitalo-Universitaire de Grenoble, BP217, France.

Studies have observed that deaf signers have a larger Visual Field (VF) than hearing non-signers with a particular large extension in the lower part of the VF. This increment could stem from early deafness or from the extensive use of sign language, since the lower VF is critical to perceive and understand linguistics gestures in sign language communication. The aim of the present study was to explore the potential impact of sign language experience without deafness on the VF sensitivity within its lower part. Read More

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http://dx.doi.org/10.1016/j.visres.2018.08.003DOI Listing
December 2018
19 Reads

Brain mechanisms for perceiving illusory lines in humans.

Neuroimage 2018 11 7;181:182-189. Epub 2018 Jul 7.

The LINE (Laboratory for Investigative Neurophysiology), Department of Radiology and Department of Clinical Neurosciences, University Hospital Center and University of Lausanne, Lausanne, Switzerland; Department of Ophthalmology, University of Lausanne, Fondation Asile des Aveugles, Lausanne, Switzerland; Electroencephalography Brain Mapping Core, Center for Biomedical Imaging (CIBM) of Lausanne and Geneva, Switzerland; Department of Hearing and Speech Sciences, Vanderbilt University, Nashville, TN, USA. Electronic address:

Illusory contours (ICs) are perceptions of visual borders despite absent contrast gradients. The psychophysical and neurobiological mechanisms of IC processes have been studied across species and diverse brain imaging/mapping techniques. Nonetheless, debate continues regarding whether IC sensitivity results from a (presumably) feedforward process within low-level visual cortices (V1/V2) or instead are processed first within higher-order brain regions, such as lateral occipital cortices (LOC). Read More

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http://dx.doi.org/10.1016/j.neuroimage.2018.07.017DOI Listing
November 2018
18 Reads

Sounds enhance visual completion processes.

Neuroimage 2018 10 26;179:480-488. Epub 2018 Jun 26.

The LINE (Laboratory for Investigative Neurophysiology), Department of Radiology, University Hospital Center and University of Lausanne, 1011, Lausanne, Switzerland; Department of Ophthalmology, University of Lausanne and Fondation Asile des Aveugles, 1003, Lausanne, Switzerland; The EEG Brain Mapping Core, Center for Biomedical Imaging (CIBM), University Hospital Center and University of Lausanne, 1011, Lausanne, Switzerland; Department of Hearing and Speech Sciences, Vanderbilt University, Nashville, TN, 37203-5721, USA. Electronic address:

Everyday vision includes the detection of stimuli, figure-ground segregation, as well as object localization and recognition. Such processes must often surmount impoverished or noisy conditions; borders are perceived despite occlusion or absent contrast gradients. These illusory contours (ICs) are an example of so-called mid-level vision, with an event-related potential (ERP) correlate at ∼100-150 ms post-stimulus onset and originating within lateral-occipital cortices (the IC). Read More

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http://dx.doi.org/10.1016/j.neuroimage.2018.06.070DOI Listing
October 2018
17 Reads

Sensory dominance and multisensory integration as screening tools in aging.

Sci Rep 2018 Jun 11;8(1):8901. Epub 2018 Jun 11.

The Laboratory for Investigative Neurophysiology (The LINE), Department of Radiology, and Neuropsychology and Neurorehabilitation Service, University Hospital Center and University of Lausanne, Lausanne, Switzerland.

Multisensory information typically confers neural and behavioural advantages over unisensory information. We used a simple audio-visual detection task to compare healthy young (HY), healthy older (HO) and mild-cognitive impairment (MCI) individuals. Neuropsychological tests assessed individuals' learning and memory impairments. Read More

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http://dx.doi.org/10.1038/s41598-018-27288-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995929PMC
June 2018
5 Reads

The Impact of Caloric and Non-Caloric Sweeteners on Food Intake and Brain Responses to Food: A Randomized Crossover Controlled Trial in Healthy Humans.

Nutrients 2018 May 15;10(5). Epub 2018 May 15.

The Laboratory for Investigative Neurophysiology (The LINE), Departments of Radiology and Clinical Neurosciences, University of Lausanne and Lausanne University Hospital, 1011 Lausanne, Switzerland.

Whether non-nutritive sweetener (NNS) consumption impacts food intake behavior in humans is still unclear. Discrepant sensory and metabolic signals are proposed to mislead brain regulatory centers, in turn promoting maladaptive food choices favoring weight gain. We aimed to assess whether ingestion of sucrose- and NNS-sweetened drinks would differently alter brain responses to food viewing and food intake. Read More

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http://dx.doi.org/10.3390/nu10050615DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986495PMC
May 2018
2 Reads

What's what in auditory cortices?

Neuroimage 2018 08 18;176:29-40. Epub 2018 Apr 18.

The LINE (Laboratory for Investigative Neurophysiology), Radiology Department and Department of Clinical Neurosciences, University Hospital Center and University of Lausanne, 1011, Lausanne, Switzerland; The EEG Brain Mapping Core, Center for Biomedical Imaging (CIBM), University Hospital Center and University of Lausanne, 1011, Lausanne, Switzerland; Department of Ophthalmology, University of Lausanne, Fondation Asile des Aveugles, Lausanne, Switzerland; Department of Hearing and Speech Sciences, Vanderbilt University, Nashville, TN, USA.

Distinct anatomical and functional pathways are postulated for analysing a sound's object-related ('what') and space-related ('where') information. It remains unresolved to which extent distinct or overlapping neural resources subserve specific object-related dimensions (i.e. Read More

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http://dx.doi.org/10.1016/j.neuroimage.2018.04.028DOI Listing
August 2018
3 Reads

Investigating the Ketogenic Diet As Treatment for Primary Aggressive Brain Cancer: Challenges and Lessons Learned.

Front Nutr 2018 23;5:11. Epub 2018 Feb 23.

Department of Pathology, Sparrow Hospital, Lansing, MI, United States.

Survival of glioblastoma multiforme (GBM) with the current recommended treatment is poor. Reported median survivals are approximately 8-15 months. Based on recent publications from animal models, combining cancer drugs, radiation, and diet-metabolic treatments may be a new route to better survivals. Read More

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http://journal.frontiersin.org/article/10.3389/fnut.2018.000
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http://dx.doi.org/10.3389/fnut.2018.00011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5834833PMC
February 2018
5 Reads

Visual processing deficits in 22q11.2 Deletion Syndrome.

Neuroimage Clin 2018 21;17:976-986. Epub 2017 Dec 21.

Functional Brain Mapping Laboratory, Department of Fundamental Neuroscience, University Medical School, University of Geneva, Geneva, Switzerland.

Carriers of the rare 22q11.2 microdeletion present with a high percentage of positive and negative symptoms and a high genetic risk for schizophrenia. Visual processing impairments have been characterized in schizophrenia, but less so in 22q11. Read More

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http://dx.doi.org/10.1016/j.nicl.2017.12.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5842759PMC
January 2019
37 Reads

Comparison of corneal biomechanics after myopic small-incision lenticule extraction compared to LASIK: an ex vivo study.

Clin Ophthalmol 2018 25;12:237-245. Epub 2018 Jan 25.

Department of Ophthalmology, Laservision Clinical and Research Institute, Athens, Greece.

Purpose: To investigate ex vivo potentially different corneal biomechanical properties after small-incision lenticule extraction (SMILE) versus LASIK for myopic correction.

Methods: Thirty human donor corneas were subjected to either myopic SMILE or femtosecond laser-assisted LASIK. Donor corneas were assigned to six investigative groups: Group A, -3. Read More

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http://dx.doi.org/10.2147/OPTH.S153509DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5790083PMC
January 2018
1 Read

The impact of replacing sugar- by artificially-sweetened beverages on brain and behavioral responses to food viewing - An exploratory study.

Appetite 2018 04 19;123:160-168. Epub 2017 Dec 19.

The Laboratory for Investigative Neurophysiology (The LINE), Department of Radiology and Department of Clinical Neurosciences, Vaudois University Hospital Center and University of Lausanne, Lausanne, Switzerland. Electronic address:

Several studies indicate that the outcome of nutritional and lifestyle interventions can be linked to brain 'signatures' in terms of neural reactivity to food cues. However, 'dieting' is often considered in a rather broad sense, and no study so far investigated modulations in brain responses to food cues occurring over an intervention specifically aiming to reduce sugar intake. We studied neural activity and liking in response to visual food cues in 14 intensive consumers of sugar-sweetened beverages before and after a 3-month replacement period by artificially-sweetened equivalents. Read More

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http://dx.doi.org/10.1016/j.appet.2017.12.019DOI Listing
April 2018
8 Reads

Association of copy number variations in complement factor H-Related genes among age-related macular degenerative subjects.

Kaohsiung J Med Sci 2017 Dec 6;33(12):602-608. Epub 2017 Sep 6.

Department of Medicine, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor DE, Malaysia.

Age-related macular degeneration (AMD) is the most widely recognised cause of irreversible vision loss and previous studies have suggested that the advancement of wet AMD is influenced by both modifiable and non-modifiable elements. Single nucleotide polymorphism (SNPs) and copy number of variations (CNVs) have been associated with AMD in various populations, however the results are conflicting. Our aim is to determine the CNVs of Complement Factor H-Related genes among Malaysian subjects with wet AMD. Read More

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http://dx.doi.org/10.1016/j.kjms.2017.08.003DOI Listing
December 2017
4 Reads

Slit Lamp-Based Ocular Scoring Systems in Toxicology and Drug Development: A Literature Survey.

J Ocul Pharmacol Ther 2017 12 7;33(10):707-717. Epub 2017 Nov 7.

1 Ocular Services On Demand (OSOD), LLC , Madison, Wisconsin.

Purpose: To present a survey of the features of published slit lamp-based scoring systems and their applicability in the context of modern ocular toxicology and drug development.

Methods: References describing original or modified slit lamp-based scoring systems for human or veterinary clinical patients or in investigative or toxicologic research were collected following a comprehensive literature review using textbooks and online publication searches. Each system's indications and features were compiled to facilitate comparison. Read More

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http://dx.doi.org/10.1089/jop.2017.0021DOI Listing
December 2017
13 Reads

Optic neuropathies: the tip of the neurodegeneration iceberg.

Hum Mol Genet 2017 10;26(R2):R139-R150

Doheny Eye Institute, Los Angeles, CA 90033, USA.

The optic nerve and the cells that give origin to its 1.2 million axons, the retinal ganglion cells (RGCs), are particularly vulnerable to neurodegeneration related to mitochondrial dysfunction. Optic neuropathies may range from non-syndromic genetic entities, to rare syndromic multisystem diseases with optic atrophy such as mitochondrial encephalomyopathies, to age-related neurodegenerative diseases such as Alzheimer's and Parkinson's disease where optic nerve involvement has, until recently, been a relatively overlooked feature. Read More

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http://dx.doi.org/10.1093/hmg/ddx273DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5886475PMC
October 2017
11 Reads

Modelling with a meshfree approach the cornea-aqueous humor interaction during the air puff test.

J Mech Behav Biomed Mater 2018 01 14;77:205-216. Epub 2017 Sep 14.

Dipartimento di Ingegneria Civile ed Ambientale, Po litecnico di Milano, P.za Leonardo da Vinci, 32-20133 Milano, Italy. Electronic address:

The air puff test is an in-vivo investigative procedure commonly utilized in ophthalmology to estimate the intraocular pressure. Potentially the test, quick and painless, could be combined with inverse analysis methods to characterize the patient-specific mechanical properties of the human cornea. A rapid localized air jet applied on the anterior surface induces the inward motion of the cornea, that interacts with aqueous humor-the fluid filling the narrow space between cornea and iris-with a strong influence on the dynamics of the cornea. Read More

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http://dx.doi.org/10.1016/j.jmbbm.2017.05.042DOI Listing
January 2018
1 Read

Corneal ulcer due to a rare coelomycetes fungus : Case report and global review of keratomycosis.

Indian J Ophthalmol 2017 Sep;65(9):871-874

Department of Ophthalmology, Kasturba Medical College, Manipal University, Manipal, Karnataka, India.

We present a rare case of corneal ulcer caused by a species of a coelomycetes fungus, Chaetomium strumarium. This fungal genus is a rare causative agent of keratomycosis, with only a handful of cases reported. The clinical presentation, investigative techniques, and preliminary management of our patient are reported. Read More

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http://dx.doi.org/10.4103/ijo.IJO_254_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5621274PMC
September 2017
6 Reads

Clinically undetected retinal breaks causing retinal detachment: A review of options for management.

Surv Ophthalmol 2018 Jul - Aug;63(4):579-588. Epub 2017 Aug 12.

Retina Consultants San Diego, Poway, California, USA.

The successful detection of retinal breaks is a critical step in rhegmatogenous retinal detachment surgery in order to prevent persistent/recurrent retinal detachments. Not all retinal breaks causing retinal detachments are obvious. Retinal breaks may be obscured by opacities that are either anterior segment related, lens related, or posterior segment related. Read More

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http://dx.doi.org/10.1016/j.survophthal.2017.08.002DOI Listing
September 2018
17 Reads

Auditory-visual integration modulates location-specific repetition suppression of auditory responses.

Psychophysiology 2017 Nov 28;54(11):1663-1675. Epub 2017 Jul 28.

Human Cognitive Neuroscience Lab, Department of Psychology, The Hebrew University of Jerusalem, Jerusalem, Israel.

Space is a dimension shared by different modalities, but at what stage spatial encoding is affected by multisensory processes is unclear. Early studies observed attenuation of N1/P2 auditory evoked responses following repetition of sounds from the same location. Here, we asked whether this effect is modulated by audiovisual interactions. Read More

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http://dx.doi.org/10.1111/psyp.12955DOI Listing
November 2017

Animal models of ocular angiogenesis: from development to pathologies.

FASEB J 2017 11 24;31(11):4665-4681. Epub 2017 Jul 24.

Department of Ophthalmology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA

Pathological angiogenesis in the eye is an important feature in the pathophysiology of many vision-threatening diseases, including retinopathy of prematurity, diabetic retinopathy, and age-related macular degeneration, as well as corneal diseases with abnormal angiogenesis. Development of reproducible and reliable animal models of ocular angiogenesis has advanced our understanding of both the normal development and the pathobiology of ocular neovascularization. These models have also proven to be valuable experimental tools with which to easily evaluate potential antiangiogenic therapies beyond eye research. Read More

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http://dx.doi.org/10.1096/fj.201700336RDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5636695PMC
November 2017
3 Reads

Treatment in early psychosis with N-acetyl-cysteine for 6months improves low-level auditory processing: Pilot study.

Schizophr Res 2018 01 12;191:80-86. Epub 2017 Jul 12.

The LINE (Laboratory for Investigative Neurophysiology), Radiodiagnostic Service, University Hospital Center and University of Lausanne, 1011 Lausanne, Switzerland; Neuropsychology and Neurorehabilitation Service and Radiodiagnostic Service, University Hospital Center and University of Lausanne, 1011 Lausanne, Switzerland; The EEG Brain Mapping Core, Center for Biomedical Imaging (CIBM), University Hospital Center and University of Lausanne, 1011 Lausanne, Switzerland; Department of Ophthalmology, University of Lausanne, Fondation Asile des Aveugles, Lausanne, Switzerland; Department of Hearing and Speech Sciences, Vanderbilt University, Nashville, TN, USA. Electronic address:

Sensory impairments constitute core dysfunctions in schizophrenia. In the auditory modality, impaired mismatch negativity (MMN) has been observed in chronic schizophrenia and may reflect N-methyl-d-aspartate (NMDA) hypo-function, consistent with models of schizophrenia based on oxidative stress. Moreover, a recent study demonstrated deficits in the N100 component of the auditory evoked potential (AEP) in early psychosis patients. Read More

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http://dx.doi.org/10.1016/j.schres.2017.07.008DOI Listing
January 2018
20 Reads

Implicit self-other discrimination affects the interplay between multisensory affordances of mental representations of faces.

Behav Brain Res 2017 08 8;333:282-285. Epub 2017 Jul 8.

The Laboratory for Investigative Neurophysiology (The LINE), Department of Radiology and Department of Clinical Neurosciences, University Hospital Center and University of Lausanne, Lausanne, Switzerland; Department of Ophthalmology, University of Lausanne, Jules-Gonin Eye Hospital, Lausanne, Switzerland; Rehabilitation Engineering Laboratory, Institute of Robotics and Intelligent Systems, Swiss Federal Institute of Technology (ETHZ), Zurich, Switzerland. Electronic address:

Face recognition is an apparently straightforward but, in fact, complex ability, encompassing the activation of at least visual and somatosensory representations. Understanding how identity shapes the interplay between these face-related affordances could clarify the mechanisms of self-other discrimination. To this aim, we exploited the so-called "face inversion effect" (FIE), a specific bias in the mental rotation of face images (of other people): with respect to inanimate objects, face images require longer time to be mentally rotated from the upside-down. Read More

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http://dx.doi.org/10.1016/j.bbr.2017.06.044DOI Listing
August 2017
1 Read

A Promising Tool in Retina Regeneration: Current Perspectives and Challenges When Using Mesenchymal Progenitor Stem Cells in Veterinary and Human Ophthalmological Applications.

Stem Cell Rev 2017 10;13(5):598-602

Department of Experimental Biology, Wrocław University of Environmental and Life Sciences, C. K. Norwida 25, 50-375, Wrocław, Poland.

Visual impairment is a common ailment of the current world population, with more exposure to CCD screens and fluorescent lighting, approximately 285 billion people suffer from this deficiency and 13% of those are considered clinically blind. More common causes for visual impairment include age-related macular degeneration (AMD), glaucoma and diabetic retinopathy (Zhu et al. Molecular Medicine Reports, 2015; Kolb et al. Read More

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http://dx.doi.org/10.1007/s12015-017-9750-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5602072PMC
October 2017
1 Read

Invasive fungal sinusitis: treatment of the orbit.

Curr Opin Ophthalmol 2017 Sep;28(5):522-533

Department of Ophthalmology; University of California, San Francisco, California, USA.

Purpose Of Review: To summarize diagnostic techniques for invasive fungal rhinosinusitis and provide a review of treatment options once disease has spread to the orbit.

Recent Findings: Improved imaging criteria, polymerase chain reaction and other serologic tests show promise in advancing our ability to accurately diagnose invasive fungal disease. Currently, there exists three treatment options for infected orbital tissue: exenteration, conservative debridement and transcutaneous retrobulbar injection of amphotericin B. Read More

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http://dx.doi.org/10.1097/ICU.0000000000000394DOI Listing
September 2017
15 Reads

Electrically Assisted Movement Therapy in Chronic Stroke Patients With Severe Upper Limb Paresis: A Pilot, Single-Blind, Randomized Crossover Study.

Arch Phys Med Rehabil 2017 08 9;98(8):1628-1635.e2. Epub 2017 May 9.

Center for Neuroprosthetics, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.

Objective: To evaluate the effects of electrically assisted movement therapy (EAMT) in which patients use functional electrical stimulation, modulated by a custom device controlled through the patient's unaffected hand, to produce or assist task-specific upper limb movements, which enables them to engage in intensive goal-oriented training.

Design: Randomized, crossover, assessor-blinded, 5-week trial with follow-up at 18 weeks.

Setting: Rehabilitation university hospital. Read More

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http://dx.doi.org/10.1016/j.apmr.2017.02.020DOI Listing
August 2017
36 Reads

A multisensory perspective on object memory.

Neuropsychologia 2017 Oct 8;105:243-252. Epub 2017 Apr 8.

The Laboratory for Investigative Neurophysiology (The LINE), Neuropsychology & Neurorehabilitation Service & Department of Radiology, University Hospital Center and University of Lausanne, Lausanne, Switzerland; Department of Hearing and Speech Sciences, Vanderbilt University Medical Center, Nashville, TN, USA; EEG Brain Mapping Core, Center for Biomedical Imaging (CIBM) of Lausanne and Geneva, Lausanne, Switzerland; Department of Ophthalmology, University of Lausanne, Jules-Gonin Eye Hospital, Lausanne, Switzerland. Electronic address:

Traditional studies of memory and object recognition involved objects presented within a single sensory modality (i.e., purely visual or purely auditory objects). Read More

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http://dx.doi.org/10.1016/j.neuropsychologia.2017.04.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5632572PMC
October 2017
9 Reads

The relationship between retinal nerve fibre layer thickness profiles and CorvisST tonometry measured biomechanical properties in young healthy subjects.

Sci Rep 2017 03 24;7(1):414. Epub 2017 Mar 24.

Department of Ophthalmology, The University of Tokyo, Tokyo, Japan.

We previously reported that a shallow circumpapillary retinal nerve fiber layer (cpRNFL) peak angle as measured by optical coherence tomography (OCT) suggests the temporal retina is stretched around the optic disc from the papillo-macular bundle (Yamashita T et al. Investigative Ophthalmol Vis Sci 2013). The purpose of the current study was to investigate the relationship between CorvisST tonometry (CST) corneal measurements, axial length (AL) and the change in OCT-measured cpRNFL peak angle, in young healthy subjects. Read More

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http://dx.doi.org/10.1038/s41598-017-00345-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5428286PMC
March 2017
7 Reads

The Dual Nature of Early-Life Experience on Somatosensory Processing in the Human Infant Brain.

Curr Biol 2017 Apr 16;27(7):1048-1054. Epub 2017 Mar 16.

Department of Hearing and Speech Sciences, Vanderbilt University Medical Center, Nashville, TN 37232, USA; The LINE (Laboratory for Investigative Neurophysiology), Department of Clinical Neurosciences and Department of Radiology, University Hospital Center and University of Lausanne, 1011 Lausanne, Switzerland; EEG Brain Mapping Core, Center for Biomedical Imaging (CIBM), 1015 Lausanne, Switzerland; Department of Ophthalmology, Jules-Gonin Eye Hospital, 1000 Lausanne, Switzerland.

Every year, 15 million preterm infants are born, and most spend their first weeks in neonatal intensive care units (NICUs) [1]. Although essential for the support and survival of these infants, NICU sensory environments are dramatically different from those in which full-term infants mature and thus likely impact the development of functional brain organization [2]. Yet the integrity of sensory systems determines effective perception and behavior [3, 4]. Read More

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http://dx.doi.org/10.1016/j.cub.2017.02.036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5388002PMC
April 2017
10 Reads

Botulinum toxin for the treatment of strabismus.

Cochrane Database Syst Rev 2017 03 2;3:CD006499. Epub 2017 Mar 2.

Department of Ophthalmology, Aintree University Hospitals NHS Foundation Trust, Lower Lane, Liverpool, UK, L9 7AL.

Background: The use of botulinum toxin as an investigative and treatment modality for strabismus is well reported in the medical literature. However, it is unclear how effective it is in comparison to other treatment options for strabismus.

Objectives: The primary objective was to examine the efficacy of botulinum toxin therapy in the treatment of strabismus compared with alternative conservative or surgical treatment options. Read More

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http://dx.doi.org/10.1002/14651858.CD006499.pub4DOI Listing
March 2017
7 Reads

Cortical thickness increases after simultaneous interpretation training.

Neuropsychologia 2017 04 9;98:212-219. Epub 2017 Jan 9.

Brain and Language Lab, Department of Clinical Neuroscience, University of Geneva, Switzerland. Electronic address:

Simultaneous interpretation is a complex cognitive task that not only demands multilingual language processing, but also requires application of extreme levels of domain-general cognitive control. We used MRI to longitudinally measure cortical thickness in simultaneous interpretation trainees before and after a Master's program in conference interpreting. We compared them to multilingual control participants scanned at the same interval of time. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00283932173000
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http://dx.doi.org/10.1016/j.neuropsychologia.2017.01.008DOI Listing
April 2017
5 Reads

Agreement and clinical comparison between a new swept-source optical coherence tomography-based optical biometer and an optical low-coherence reflectometry biometer.

Eye (Lond) 2017 Mar 11;31(3):437-442. Epub 2016 Nov 11.

Patología ocular del envejecimiento, calidad visual y calidad de vida, Instituto de Salud Carlos III, Madrid, Spain.

PurposeTo compare measurements taken using a swept-source optical coherence tomography-based optical biometer (IOLmaster 700) and an optical low-coherence reflectometry biometer (Lenstar 900), and to determine the clinical impacts of differences in their measurements on intraocular lens (IOL) power predictions.MethodsEighty eyes of 80 patients scheduled to undergo cataract surgery were examined with both biometers. The measurements made using each device were axial length (AL), central corneal thickness (CCT), aqueous depth (AQD), lens thickness (LT), mean keratometry (MK), white-to-white distance (WTW), and pupil diameter (PD). Read More

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http://www.nature.com/articles/eye2016241
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http://dx.doi.org/10.1038/eye.2016.241DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5350368PMC
March 2017
6 Reads

Controversies in ocular tuberculosis.

Br J Ophthalmol 2017 Jan 4;101(1):6-9. Epub 2016 Nov 4.

Singapore National Eye Centre, Singapore, Singapore.

Ocular tuberculosis still remains a presumptive, clinical diagnosis in the presence of supportive clinical signs and investigations, while in the absence of other possible causes of uveitis. The purpose of this review is to discuss three controversies of ocular tuberculosis today. First, it is unclear from many reports on how the diagnosis of ocular tuberculosis was defined, and if they included 'probable' or 'possible' diagnoses. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2016-309531DOI Listing
January 2017
9 Reads

Effect of pharmacological pupil dilation on measurements and iol power calculation made using the new swept-source optical coherence tomography-based optical biometer.

J Fr Ophtalmol 2016 Dec 25;39(10):859-865. Epub 2016 Oct 25.

Ophthalmology, Hospital Clínico San Carlos, Departamento de Oftalmología y ORL, Facultad de Medicina, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), 28010 Madrid, Spain.

Purpose: To determine whether pupil dilation affects biometric measurements and intraocular lens (IOL) power calculation made using the new swept-source optical coherence tomography-based optical biometer (IOLMaster 700; Carl Zeiss Meditec, Jena, Germany).

Procedures: Eighty-one eyes of 81 patients evaluated for cataract surgery were prospectively examined using the IOLMaster 700 before and after pupil dilation with tropicamide 1%. The measurements made were: axial length (AL), central corneal thickness (CCT), aqueous chamber depth (ACD), lens thickness (LT), mean keratometry (MK), white-to-white distance (WTW) and pupil diameter (PD). Read More

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http://dx.doi.org/10.1016/j.jfo.2016.09.003DOI Listing
December 2016
11 Reads

Long-Term Outcome and Recurrence of Idiopathic Choroidal Neovascularization Treated with Intravitreal Bevacizumab.

J Ocul Pharmacol Ther 2016 09 1;32(7):431-6. Epub 2016 Aug 1.

1 Department of Ophthalmology, Kim's Eye Hospital, Konyang University College of Medicine , Seoul, South Korea .

Purpose: To evaluate the long-term outcome of intravitreal bevacizumab treatment for idiopathic choroidal neovascularization (CNV) and to investigative the influence of CNV recurrence on visual prognosis.

Methods: This retrospective study included 26 patients (26 eyes) who had been diagnosed with idiopathic CNV and followed up for at least 2 years. All the eyes included had been treated with intravitreal bevacizumab. Read More

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http://dx.doi.org/10.1089/jop.2016.0066DOI Listing
September 2016
3 Reads

What makes medical students better listeners?

Curr Biol 2016 07;26(13):R519-R520

Service of Neuropsychology and Neurorehabilitation, Department of Clinical Neuroscience, CHUV, Switzerland. Electronic address:

Diagnosing heart conditions by auscultation is an important clinical skill commonly learnt by medical students. Clinical proficiency for this skill is in decline [1], and new teaching methods are needed. Successful discrimination of heartbeat sounds is believed to benefit mainly from acoustical training [2]. Read More

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http://dx.doi.org/10.1016/j.cub.2016.05.024DOI Listing
July 2016
2 Reads

Bridging the gap: Synaesthesia and multisensory processes.

Neuropsychologia 2016 07 22;88:1-4. Epub 2016 Jun 22.

Department of Hearing and Speech Sciences, Vanderbilt University Medical Center, Nashville, TN, USA; The Laboratory for Investigative Neurophysiology (TheLINE), Neuropsychology and Neurorehabilitation Service and Department of Radiology, University Hospital Center and University of Lausanne, Lausanne, Switzerland; EEG Brain Mapping Core, Center for Biomedical Imaging (CIBM) of Lausanne and Geneva, Lausanne, Switzerland; Department of Ophthalmology, University of Lausanne, Jules Gonin Eye Hospital, Lausanne, Switzerland.

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http://dx.doi.org/10.1016/j.neuropsychologia.2016.06.007DOI Listing
July 2016
7 Reads

Diagnosing the cause of bilateral paediatric cataracts: comparison of standard testing with a next-generation sequencing approach.

Eye (Lond) 2016 Sep 17;30(9):1175-81. Epub 2016 Jun 17.

Department of Ophthalmology, Manchester Royal Eye Hospital, Central Manchester Foundation Trust and Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK.

PurposeIn addition to environmental causes such as TORCH infection, trauma and drug or chemical exposure, childhood cataracts (CC) frequently have a genetic basis. They may be isolated or syndromic and have been associated with mutations in over 110 genes. We have recently demonstrated that next-generation sequencing (NGS), a high throughput sequencing technique that enables the parallel sequencing of multiple genes, is ideally suited to the investigation of bilateral CC. Read More

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http://dx.doi.org/10.1038/eye.2016.105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5023796PMC
September 2016

Multisensory Processes: A Balancing Act across the Lifespan.

Trends Neurosci 2016 08 6;39(8):567-579. Epub 2016 Jun 6.

Department of Hearing and Speech Sciences, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Psychology, Vanderbilt University, Nashville, TN, USA; Kennedy Center for Research on Human Development, Vanderbilt University, Nashville, TN, USA; Department of Psychiatry, Vanderbilt University, Nashville, TN, USA; Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN, USA. Electronic address:

Multisensory processes are fundamental in scaffolding perception, cognition, learning, and behavior. How and when stimuli from different sensory modalities are integrated rather than treated as separate entities is poorly understood. We review how the relative reliance on stimulus characteristics versus learned associations dynamically shapes multisensory processes. Read More

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http://dx.doi.org/10.1016/j.tins.2016.05.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4967384PMC
August 2016
7 Reads

Shaping Intrinsic Neural Oscillations with Periodic Stimulation.

J Neurosci 2016 05;36(19):5328-37

The Laboratory for Investigative Neurophysiology (The LINE), Department of Clinical Neurosciences and Department of Radiology, University Hospital Center and University of Lausanne, Lausanne 1011, Switzerland, Krembil Research Institute, University Health Network, Toronto, Ontario M5T 2S8, Canada, and Department of Mathematics, University of Toronto, Toronto, Ontario M5S 3G3, Canada

Unlabelled: Rhythmic brain activity plays an important role in neural processing and behavior. Features of these oscillations, including amplitude, phase, and spectrum, can be influenced by internal states (e.g. Read More

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http://dx.doi.org/10.1523/JNEUROSCI.0236-16.2016DOI Listing
May 2016
1 Read

Bilateral implantation of +2.5 D multifocal intraocular lens and contralateral implantation of +2.5 D and +3.0 D multifocal intraocular lenses: Clinical outcomes.

J Cataract Refract Surg 2016 Feb;42(2):194-202

From the University Eye Clinic (Nuijts, Jonker), Maastricht University Medical Center, Maastricht, and the Ophthalmology Department (Lapid-Gortzak), Academic Medical Center, Amsterdam, the Netherlands; Kaufer Clinica de Ojos (Kaufer), Buenos Aires, Argentina; Servicio de Oftalmologia (Mendicute), Hospital Universitario Donostia, San Sebastian, and the Fundacion Oftalmologica del Mediterraneo (Martinez), Valencia, Spain; Augen-Zentrum-Nordwest (Schmickler), Ahaus, and the Department of Ophthalmology (Kohnen), Goethe-University, Frankfurt, Germany.

Purpose: To assess the clinical visual outcomes of bilateral implantation of Restor +2.5 diopter (D) multifocal intraocular lenses (IOLs) and contralateral implantation of a Restor +2.5 D multifocal IOL in the dominant eye and Restor +3. Read More

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http://dx.doi.org/10.1016/j.jcrs.2016.02.009DOI Listing
February 2016
7 Reads
2 Citations
2.722 Impact Factor

The use of intracorneal ring segments in keratoconus.

Eye Vis (Lond) 2016 15;3. Epub 2016 Mar 15.

Keratoconus Unit, Vissum Alicante, Calle Cabañal, 1 Edificio Vissum, 03016 Alicante, Spain ; Division of Ophthalmology, Universidad Miguel Hernández, Alicante, Spain.

Keratoconus is a corneal degeneration that usually appears during puberty and may seriously deteriorate the quality of life of the patients. This corneal disease is today the first indication of corneal transplantation in young patients. Until the last decade of the XX century, keratoplasty procedures were the only alternative to treat this pathological condition. Read More

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http://www.eandv.org/content/3/1/8
Publisher Site
http://dx.doi.org/10.1186/s40662-016-0040-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4791885PMC
March 2016
7 Reads

The COGs (context, object, and goals) in multisensory processing.

Exp Brain Res 2016 May 1;234(5):1307-23. Epub 2016 Mar 1.

The Laboratory for Investigative Neurophysiology (The LINE), Neuropsychology and Neurorehabilitation Service and Department of Radiology, Centre Hospitalier Universitaire Vaudois (CHUV), University Hospital Center and University of Lausanne, BH7.081, rue du Bugnon 46, 1011, Lausanne, Switzerland.

Our understanding of how perception operates in real-world environments has been substantially advanced by studying both multisensory processes and "top-down" control processes influencing sensory processing via activity from higher-order brain areas, such as attention, memory, and expectations. As the two topics have been traditionally studied separately, the mechanisms orchestrating real-world multisensory processing remain unclear. Past work has revealed that the observer's goals gate the influence of many multisensory processes on brain and behavioural responses, whereas some other multisensory processes might occur independently of these goals. Read More

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http://dx.doi.org/10.1007/s00221-016-4590-zDOI Listing
May 2016
5 Reads

Cue-dependent circuits for illusory contours in humans.

Neuroimage 2016 Apr 28;129:335-344. Epub 2016 Jan 28.

The Laboratory for Investigative Neurophysiology (The LINE), Department of Clinical Neurosciences, University Hospital Center and University of Lausanne, Lausanne, Switzerland; The Laboratory for Investigative Neurophysiology (The LINE), Department of Radiology, University Hospital Center and University of Lausanne, Lausanne, Switzerland; Electroencephalography Brain Mapping Core, Center for Biomedical Imaging (CIBM) of Lausanne and Geneva, Switzerland; Department of Ophthalmology, University of Lausanne, Jules-Gonin Eye Hospital, Lausanne, Switzerland; Department of Hearing and Speech Sciences, Vanderbilt University, Nashville, TN, USA. Electronic address:

Objects' borders are readily perceived despite absent contrast gradients, e.g. due to poor lighting or occlusion. Read More

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http://dx.doi.org/10.1016/j.neuroimage.2016.01.052DOI Listing
April 2016
2 Reads

Introduction to the special issue on functional selectivity in perceptual and cognitive systems--a tribute to Shlomo Bentin (1946-2012).

Neuropsychologia 2016 Mar 28;83:1-4. Epub 2016 Jan 28.

Institute of Research in Psychology and Institute of Neuroscience, University of Louvain, 10 Place Cardinal Mercier, Louvain-la-Neuve 1348, Belgium.

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http://dx.doi.org/10.1016/j.neuropsychologia.2016.01.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4924878PMC
March 2016
2 Reads

In pursuit of objective dry eye screening clinical techniques.

Eye Vis (Lond) 2016 18;3. Epub 2016 Jan 18.

Laservision.gr Clinical and Research Eye Institute, 17 Tsocha Street, Athens, 11521 Greece.

Dry eye is a multifactorial, progressive, and chronic disease of the tears and ocular surface. The disease is multi-factorial and has intermittent symptoms. Discomfort, visual disturbance, tear film instability with potential damage to the ocular surface, and increased tear film osmolarity are known associates. Read More

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http://dx.doi.org/10.1186/s40662-015-0032-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4716631PMC
January 2016
2 Citations