6,428 results match your criteria Investigative Radiology[Journal]


Acute Adverse Reactions to Nonionic Iodinated Contrast Media: A Meta-Analysis.

Invest Radiol 2019 Apr 16. Epub 2019 Apr 16.

Department of Radiology, Seoul National University Hospital, Seoul National University College of Medicine.

Objectives: We aimed to meta-analytically compare the incidence of acute adverse reactions (AARs) to nonionic iodinated contrast media (ICM) according to the type of ICM in patients who underwent radiologic examinations with administration of ICM via intravascular route.

Materials And Methods: A systematic literature search identified studies evaluating the incidence of AARs to 7 nonionic ICM (iobitridol, iohexol, iomeprol, iopamidol, iopromide, ioversol, and iodixanol) with extractable outcomes. These outcomes were pooled using a random-effects model, and the effect of ICM type on the incidence of overall and severe AARs was evaluated using meta-regression analysis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/RLI.0000000000000568DOI Listing

Targeted Biopsy Validation of Peripheral Zone Prostate Cancer Characterization With Magnetic Resonance Fingerprinting and Diffusion Mapping.

Invest Radiol 2019 Apr 12. Epub 2019 Apr 12.

Case Western University School of Medicine, Departments of.

Objective: This study aims for targeted biopsy validation of magnetic resonance fingerprinting (MRF) and diffusion mapping for characterizing peripheral zone (PZ) prostate cancer and noncancers.

Materials And Methods: One hundred four PZ lesions in 85 patients who underwent magnetic resonance imaging were retrospectively analyzed with apparent diffusion coefficient (ADC) mapping, MRF, and targeted biopsy (cognitive or in-gantry). A radiologist blinded to pathology drew regions of interest on targeted lesions and visually normal peripheral zone on MRF and ADC maps. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/RLI.0000000000000569DOI Listing
April 2019
4.437 Impact Factor

Physicochemical and Pharmacokinetic Profiles of Gadopiclenol: A New Macrocyclic Gadolinium Chelate With High T1 Relaxivity.

Invest Radiol 2019 Apr 4. Epub 2019 Apr 4.

Laboratoire de Génomique, Bioinformatique et Chimie Moléculaire (EA 7528), Equipe Chimie Moléculaire, Conservatoire National des Arts et Métiers (CNAM), HESAM Université, Paris, France.

Objectives: We aimed to evaluate gadopiclenol, a newly developed extracellular nonspecific macrocyclic gadolinium-based contrast agent (GBCA) having high relaxivity properties, which was designed to increase lesion detection and characterization by magnetic resonance imaging.

Methods: We described the molecular structure of gadopiclenol and measured the r1 and r2 relaxivity properties at fields of 0.47 and 1. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/RLI.0000000000000563DOI Listing

Age, But Not Repeated Exposure to Gadoterate Meglumine, Is Associated With T1- and T2-Weighted Signal Intensity Changes in the Deep Brain Nuclei of Pediatric Patients.

Invest Radiol 2019 Apr 8. Epub 2019 Apr 8.

From the Department of Radiology, Lausanne University Hospital, Lausanne, Switzerland.

Objectives: Current findings on gadolinium deposition in the pediatric brain due to repeated exposure to macrocyclic contrast agents are inconclusive and possibly confounded by brain maturation processes. We evaluated the longitudinal effects of repeated gadoterate meglumine exposure (Dotarem; Guerbet, Villepinte, France) on the T1- and T2-weighted signal intensity (SI) in pediatric patients, and assessed the magnitude of age-related increase in T1-weighted (and decrease in T2-weighted) SI in a control cohort without prior gadolinium exposure.

Materials And Methods: In this retrospective, double-cohort study, magnetic resonance imaging (MRI) data of 24 patients (0. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/RLI.0000000000000564DOI Listing
April 2019
1 Read

Motion in Magnetic Resonance: New Paradigms for Improved Clinical Diagnosis.

Invest Radiol 2019 Apr 3. Epub 2019 Apr 3.

From the Department of Diagnostic, Interventional and Pediatric Radiology, University Hospital of Bern, Inselspital, University of Bern, Bern, Switzerland.

Recent innovations in magnetic resonance, involving both hardware and software, that effectively deal with motion-whether inadvertent on the part of the patient or due to respiration and cardiac contraction-are reviewed, emphasizing major current advances. New technology involving motion sensing (kinetic, respiratory, and beat) is enabling simpler, faster, and more robust monitoring of the sources of motion. This information is being integrated, with new innovative imaging approaches, to effectively manage motion and its impact on image quality. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/RLI.0000000000000566DOI Listing

Simultaneous Multislice Echo Planar Imaging for Accelerated Diffusion-Weighted Imaging of Malignant and Benign Breast Lesions.

Invest Radiol 2019 Apr 3. Epub 2019 Apr 3.

Siemens Healthcare, Erlangen, Germany.

Objectives: Comparison of the diagnostic value of simultaneous multislice (SMS) accelerated diffusion-weighted echo planar imaging (EPI) of malignant and benign lesions of the breast compared with a reference EPI sequence.

Materials And Methods: The study was approved by the institutional ethics committee. Sixty-eight patients were examined with a diffusion-weighted EPI (reference EPI; TE = 54 milliseconds; TR = 9000 milliseconds; TA, 3:27 minutes) and a diffusion-weighted SMS accelerated EPI (SMS EPI; acceleration factor 2; TE = 58 milliseconds; TR = 4300 milliseconds; TA, 1:53 minutes) in addition to the standard magnetic resonance imaging (MRI) protocol. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/RLI.0000000000000560DOI Listing

A Single-Arm, Multicenter Validation Study of Prostate Cancer Localization and Aggressiveness With a Quantitative Multiparametric Magnetic Resonance Imaging Approach.

Invest Radiol 2019 Apr 3. Epub 2019 Apr 3.

Department of Radiology and Nuclear Medicine, Ghent University Hospital, Gent, Belgium.

Objectives: The aims of this study were to assess the discriminative performance of quantitative multiparametric magnetic resonance imaging (mpMRI) between prostate cancer and noncancer tissues and between tumor grade groups (GGs) in a multicenter, single-vendor study, and to investigate to what extent site-specific differences affect variations in mpMRI parameters.

Materials And Methods: Fifty patients with biopsy-proven prostate cancer from 5 institutions underwent a standardized preoperative mpMRI protocol. Based on the evaluation of whole-mount histopathology sections, regions of interest were placed on axial T2-weighed MRI scans in cancer and noncancer peripheral zone (PZ) and transition zone (TZ) tissue. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/RLI.0000000000000558DOI Listing

Gadolinium Presence in the Brain After Administration of the Liver-Specific Gadolinium-Based Contrast Agent Gadoxetate: A Systematic Comparison to Multipurpose Agents in Rats.

Invest Radiol 2019 Mar 29. Epub 2019 Mar 29.

From the MR and CT Contrast Media Research, and.

Objective: Clinical studies have reported different results regarding the signal intensity (SI) increase in the dentate nucleus on unenhanced T1-weighted magnetic resonance imaging (MRI) after repeated administrations of gadolinium-based contrast agents (GBCAs). The aim of this study was to evaluate MRI SI changes and gadolinium (Gd) brain concentrations in an animal model after repeated administration of liver-specific linear gadoxetate in comparison to multipurpose linear and macrocyclic GBCAs. Recently, it was demonstrated that small amounts of GBCAs are able to cross the blood-cerebrospinal fluid (CSF) barrier. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/RLI.0000000000000559DOI Listing

Agreement and Reproducibility of Proton Density Fat Fraction Measurements Using Commercial MR Sequences Across Different Platforms: A Multivendor, Multi-Institutional Phantom Experiment.

Invest Radiol 2019 Mar 25. Epub 2019 Mar 25.

Department of Radiology, Anam Hospital, Korea University College of Medicine, Seoul, South Korea.

Objectives: The aim of this study was to evaluate the agreement and reproducibility of proton density fat fraction (PDFF) measurements using commercial magnetic resonance (MR) sequences across different imagers, vendors, and field strengths via a phantom experiment.

Materials And Methods: Eleven fat-water emulsion phantoms of varying fat proportions (ie, 0-50 weight%) were constructed. Phantom PDFFs were estimated using commercial chemical shift-based MR imaging sequences with Siemens 1. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/RLI.0000000000000561DOI Listing
March 2019
1 Read

Breast Cancer Assessment With Pulse-Echo Speed of Sound Ultrasound From Intrinsic Tissue Reflections: Proof-of-Concept.

Invest Radiol 2019 Mar 25. Epub 2019 Mar 25.

Computer-Assisted Applications in Medicine, ETH Zurich.

Purpose: The aim of this study was to differentiate malignant and benign solid breast lesions with a novel ultrasound (US) technique, which measures speed of sound (SoS) using standard US transducers and intrinsic tissue reflections and scattering (speckles) as internal reference.

Materials And Methods: This prospective, institutional review board-approved, Health Insurance Portability and Accountability Act-compliant prospective comparison study was performed with prior written informed consent from 20 women. Ten women with histological proven breast cancer and 10 with fibroadenoma were measured. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/RLI.0000000000000553DOI Listing
March 2019
1 Read

Single-Center Retrospective Analysis of Breakthrough Allergic-Like Reactions to Gadobutrol.

Invest Radiol 2019 Mar 14. Epub 2019 Mar 14.

From the Department of Medical Imaging, The Ottawa Hospital, Ottawa, Ontario, Canada.

Objective: The purpose of this study was to assess the rate and severity of breakthrough allergic-like reactions to gadobutrol.

Materials And Methods: Under a waiver from our institutional review board, we performed a key word search of our institutional PACS (Picture Archiving and Communication System) database to identify all allergic-like reactions, which occurred in the setting of gadobutrol administration between December 2009 and August 2018, encompassing approximately 25,000 gadobutrol injections. Patients with an index allergic-like reaction who underwent a subsequent gadobutrol-enhanced magnetic resonance imaging after a standard 13-hour corticosteroid and antihistamine premedication protocol before repeat injection were identified. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/RLI.0000000000000557DOI Listing

Assessment of Pharmacokinetic, Pharmacodynamic Profile, and Tolerance of Gadopiclenol, A New High Relaxivity GBCA, in Healthy Subjects and Patients With Brain Lesions (Phase I/IIa Study).

Invest Radiol 2019 Mar 12. Epub 2019 Mar 12.

From the Guerbet, Roissy CDG Cedex, France.

Objectives: The aim of this study was to evaluate the pharmacokinetics, safety profile, and pharmacodynamics of gadopiclenol, a new high relaxivity macrocyclic gadolinium-based contrast agent, in healthy subjects and patients with brain lesions.

Materials And Methods: This was a single ascending dose phase I/IIa study. Phase I was double-blind, randomized, placebo-controlled and included 54 healthy subjects. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/RLI.0000000000000556DOI Listing
March 2019
5 Reads

Dedicated Breast Computed Tomography With a Photon-Counting Detector: Initial Results of Clinical In Vivo Imaging.

Invest Radiol 2019 Mar 2. Epub 2019 Mar 2.

Institute of Medical Physics, University of Erlangen-Nürnberg, Germany.

Objectives: The purpose of this work is to present the data obtained from the first clinical in vivo application of a new dedicated spiral breast computed tomography (B-CT) equipped with a photon-counting detector.

Materials And Methods: The institutional review board approved this retrospective study. Twelve women referred for breast cancer screening were included and underwent bilateral spiral B-CT acquired in prone position. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/RLI.0000000000000552DOI Listing
March 2019
7 Reads

Automated Detection and Segmentation of Multiple Sclerosis Lesions Using Ultra-High-Field MP2RAGE.

Invest Radiol 2019 Mar 2. Epub 2019 Mar 2.

Neurologic Clinic and Policlinic, Departments of Medicine, Clinical Research, and Biomedical Engineering, University Hospital Basel and University of Basel, Basel, Switzerland.

Objectives: The aim of this study was to develop a new automated segmentation method of white matter (WM) and cortical multiple sclerosis (MS) lesions visible on magnetization-prepared 2 inversion-contrast rapid gradient echo (MP2RAGE) images acquired at 7 T MRI.

Materials And Methods: The proposed prototype (MSLAST [Multiple Sclerosis Lesion Analysis at Seven Tesla]) takes as input a single image contrast derived from the 7T MP2RAGE prototype sequence and is based on partial volume estimation and topological constraints. First, MSLAST performs a skull-strip of MP2RAGE images and computes tissue concentration maps for WM, gray matter (GM), and cerebrospinal fluid (CSF) using a partial volume model of tissues within each voxel. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/RLI.0000000000000551DOI Listing
March 2019
2 Reads
4.437 Impact Factor

Digital Variance Angiography as a Paradigm Shift in Carbon Dioxide Angiography.

Invest Radiol 2019 Feb 28. Epub 2019 Feb 28.

The Heart and Vascular Center, and.

Objectives: Our aim was to investigate the feasibility of digital variance angiography (DVA) in lower extremity CO2 angiography and to compare the quantitative and qualitative performance of the new image processing technique with that of the current reference standard digital subtraction angiography (DSA).

Materials And Methods: This prospective study enrolled 24 patients (mean age ± SD, 65.5 ± 9. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/RLI.0000000000000555DOI Listing
February 2019

Pancreatic Steatosis Is Associated With Impaired Exocrine Pancreatic Function.

Invest Radiol 2019 Feb 26. Epub 2019 Feb 26.

Department of Radiology, University of Yamanashi, Shimokato, Chuo, Japan.

Objectives: The aim of this study was to investigate if pancreatic steatosis measured by proton density fat fraction (PDFF) is associated with exocrine pancreatic function defined by fecal elastase concentrations.

Materials And Methods: A total of 1458 volunteers (777 women; age range, 21-88 years) underwent magnetic resonance imaging of the pancreas, and organ fat content was quantified by using confounder corrected PDFF. Exocrine pancreatic function was categorized by fecal elastase levels using defined cutoffs: greater than 200 μg/g normal function (n = 1319) and 200 μg/g or less impaired function (n = 139). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/RLI.0000000000000554DOI Listing
February 2019
2 Reads

Compressed Sensing and Parallel Imaging for Double Hepatic Arterial Phase Acquisition in Gadoxetate-Enhanced Dynamic Liver Magnetic Resonance Imaging.

Invest Radiol 2019 Feb 1. Epub 2019 Feb 1.

From the Department of Radiology, Research Institute of Radiological Science, Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea.

Objectives: The aim of this study was to investigate the utility of a combined compressed sensing and parallel imaging (C-SENSE) technique for single breath-hold, double arterial phase (AP) examinations in gadoxetate-enhanced magnetic resonance imaging (MRI) of the liver.

Materials And Methods: We retrospectively reviewed single breath-hold, double AP images obtained by using a C-SENSE technique for gadoxetate-enhanced dynamic liver MRI in a total of 127 patients (89 men and 38 women; mean age, 62.6 ± 7. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/RLI.0000000000000548DOI Listing
February 2019
1 Read
4.437 Impact Factor

The Impact of Echo Time Shifts and Temporal Signal Fluctuations on BOLD Sensitivity in Presurgical Planning at 7 T.

Invest Radiol 2019 Feb 1. Epub 2019 Feb 1.

Study Group Clinical fMRI, Department of Neurology, Medical University of Vienna, Vienna.

Objectives: Gradients in the static magnetic field caused by tissues with differing magnetic susceptibilities lead to regional variations in the effective echo time, which modifies both image signal and BOLD sensitivity. Local echo time changes are not considered in the most commonly used metric for BOLD sensitivity, temporal signal-to-noise ratio (tSNR), but may be significant, particularly at ultrahigh field close to air cavities (such as the sinuses and ear canals) and near gross brain pathologies and postoperative sites.

Materials And Methods: We have studied the effect of local variations in echo time and tSNR on BOLD sensitivity in 3 healthy volunteers and 11 patients with tumors, postoperative cavities, and venous malformations at 7 T. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/RLI.0000000000000546DOI Listing
February 2019
2 Reads

Individually Body Weight-Adapted Contrast Media Application in Computed Tomography Imaging of the Liver at 90 kVp.

Invest Radiol 2019 Mar;54(3):177-182

From the Department of Radiology and Nuclear Medicine; and CARIM School for Cardiovascular Diseases, Maastricht University Medical Center, Maastricht, the Netherlands.

Objectives: The aim of the present study was to evaluate the attenuation and image quality (IQ) of a body weight-adapted contrast media (CM) protocol compared with a fixed injection protocol in computed tomography (CT) of the liver at 90 kV.

Materials And Methods: One hundred ninety-nine consecutive patients referred for abdominal CT imaging in portal venous phase were included. Group 1 (n = 100) received a fixed CM dose with a total iodine load (TIL) of 33 g I at a flow rate of 3. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/RLI.0000000000000525DOI Listing
March 2019
1 Read

Acceleration of Double Inversion Recovery Sequences in Multiple Sclerosis With Compressed Sensing.

Invest Radiol 2019 Jan 31. Epub 2019 Jan 31.

Department of Neurology, and.

Objective: The aim of this study was to assess the performance of double inversion recovery (DIR) sequences accelerated by compressed sensing (CS) in a clinical setting.

Materials And Methods: We included 106 patients with MS (62 female [58%]; mean age, 44.9 ± 11. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/RLI.0000000000000550DOI Listing
January 2019
1 Read

Ultrashort Time to Echo Magnetic Resonance Evaluation of Calcium Pyrophosphate Crystal Deposition in Human Menisci.

Invest Radiol 2019 Jan 25. Epub 2019 Jan 25.

Department of Radiology, VA San Diego Healthcare System, San Diego, CA.

Objectives: In human menisci, we aimed to investigate whether calcium pyrophosphate crystal deposition (CPPD) affects biomechanical and quantitative MR properties, and their zonal distribution.

Materials And Methods: From 9 cadaveric knees, sectioned triangular meniscus pieces were harvested. Samples were classified into "normal" or "CPPD" groups based upon visual inspection. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/RLI.0000000000000547DOI Listing
January 2019

Longitudinal Visualization of Viable Cancer Cell Intratumoral Distribution in Mouse Models Using Oatp1a1-Enhanced Magnetic Resonance Imaging.

Invest Radiol 2019 May;54(5):302-311

Medical Imaging Laboratories, Robarts Research Institute, London, Ontario.

Objectives: Multimodality reporter gene imaging provides valuable, noninvasive information on the fate of engineered cell populations. To complement magnetic resonance imaging (MRI) measures of tumor volume and 2-dimensional reporter-based optical measures of cell viability, reporter-based MRI may offer 3-dimensional information on the distribution of viable cancer cells in deep tissues.

Materials And Methods: Here, we engineered human and murine triple-negative breast cancer cells with lentivirus encoding tdTomato and firefly luciferase for fluorescence imaging and bioluminescence imaging (BLI). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/RLI.0000000000000542DOI Listing

Instant Outcome Evaluation of Microwave Ablation With Subtraction CT in an In Vivo Porcine Model.

Invest Radiol 2019 Jan 15. Epub 2019 Jan 15.

From the Departments of Radiology, and.

Objectives: The aim of this study was to investigate whether the accuracy of multislice contrast-enhanced computed tomography (MS-CECT) may be improved by performing additional subtraction CT.

Materials And Methods: Thirty-five microwave ablations were performed under CT guidance in 12 healthy and anesthetized pigs. Preablation and postablation MS-CECT scans were obtained in arterial and venous contrast phases. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/RLI.0000000000000545DOI Listing
January 2019
3 Reads

Artificial Intelligence-Based Classification of Breast Lesions Imaged With a Multiparametric Breast MRI Protocol With Ultrafast DCE-MRI, T2, and DWI.

Invest Radiol 2019 Jan 15. Epub 2019 Jan 15.

From the Departments of Radiology and Nuclear Medicine, and.

Objectives: We investigated artificial intelligence (AI)-based classification of benign and malignant breast lesions imaged with a multiparametric breast magnetic resonance imaging (MRI) protocol with ultrafast dynamic contrast-enhanced MRI, T2-weighted, and diffusion-weighted imaging with apparent diffusion coefficient mapping.

Materials And Methods: We analyzed 576 lesions imaged with MRI, including a consecutive set of biopsied malignant (368) and benign (149) lesions, and an additional set of 59 benign lesions proven by follow-up. We used deep learning methods to interpret ultrafast dynamic contrast-enhanced MRI and T2-weighted information. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/RLI.0000000000000544DOI Listing
January 2019
8 Reads

Quantitative Multiparametric Breast Ultrasound: Application of Contrast-Enhanced Ultrasound and Elastography Leads to an Improved Differentiation of Benign and Malignant Lesions.

Invest Radiol 2019 May;54(5):257-264

Memorial Sloan-Kettering Cancer Center, Department of Radiology, Molecular Imaging and Therapy Service, New York, NY.

Objectives: The aim of this study was to evaluate breast multiparametric ultrasound (mpUS) and its potential to reduce unnecessary breast biopsies with 1, 2, or 3 additional quantitative parameters (Doppler, elastography, and contrast-enhanced ultrasound [CEUS]) to B-mode and investigate possible variations with different reader experience.

Materials And Methods: This prospective study included 124 women (age range, 18-82 years; mean, 52 years), each with 1 new breast lesion, scheduled for ultrasound-guided biopsy between October 2015 and September 2016. Each lesion was examined with B-mode, elastography (Virtual Touch IQ [VTIQ]), Doppler, and CEUS, and different quantitative parameters were recorded for each modality. Read More

View Article

Download full-text PDF

Source
http://Insights.ovid.com/crossref?an=00004424-900000000-9894
Publisher Site
http://dx.doi.org/10.1097/RLI.0000000000000543DOI Listing
May 2019
8 Reads

Accelerated Segmented Diffusion-Weighted Prostate Imaging for Higher Resolution, Higher Geometric Fidelity, and Multi-b Perfusion Estimation.

Invest Radiol 2019 Apr;54(4):238-246

Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

Purpose: The aim of this study was to improve the geometric fidelity and spatial resolution of multi-b diffusion-weighted magnetic resonance imaging of the prostate.

Materials And Methods: An accelerated segmented diffusion imaging sequence was developed and evaluated in 25 patients undergoing multiparametric magnetic resonance imaging examinations of the prostate. A reduced field of view was acquired using an endorectal coil. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/RLI.0000000000000536DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402959PMC
April 2019
1 Read

Matching and Homogenizing Convolution Kernels for Quantitative Studies in Computed Tomography.

Invest Radiol 2019 May;54(5):288-295

Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston.

The sharpness of the kernels used for image reconstruction in computed tomography affects the values of the quantitative image features. We sought to identify the kernels that produce similar feature values to enable a more effective comparison of images produced using scanners from different manufactures. We also investigated a new image filter designed to change the kernel-related component of the frequency spectrum of a postreconstruction image from that of the initial kernel to that of a preferred kernel. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/RLI.0000000000000540DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449212PMC
May 2019
5 Reads

Low-Dose Perfusion Computed Tomography for Breast Cancer to Quantify Tumor Vascularity: Correlation With Prognostic Biomarkers.

Invest Radiol 2019 May;54(5):273-281

Division of Breast and Endocrine Surgery, Department of Surgery, Korea University Ansan Hospital, Korea University College of Medicine, Gyeonggi-do, Republic of Korea.

Objectives: The aim of this study was to investigate the feasibility of using low-dose perfusion computed tomography (CT) in breast cancers for quantification of tumor vascularity and to correlate perfusion indexes with prognostic biomarkers.

Materials And Methods: This preliminary study was approved by our institutional review board. Signed informed consent was obtained from all 70 enrolled patients with invasive breast cancers. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/RLI.0000000000000538DOI Listing
May 2019
13 Reads

Automatic Tube Current Modulation and Tube Voltage Selection in Pediatric Computed Tomography: A Phantom Study on Radiation Dose and Image Quality.

Invest Radiol 2019 May;54(5):265-272

Medical Physics Department, University of Crete, Stavrakia, Crete, Greece.

Objectives: The aim of this study was to investigate the effects of a modern automatic tube current modulation (ATCM) and automatic tube voltage selection (ATVS) system on radiation dose and image quality in pediatric head, and torso computed tomography (CT) examinations for various clinical indications.

Materials And Methods: Four physical anthropomorphic phantoms that represent the average individual as neonate, 1-year-old, 5-year-old, and 10-year-old child were used. Standard head, thorax, and abdomen/pelvis acquisitions were performed with (1) fixed tube current, (2) ATCM, and (3) ATVS. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/RLI.0000000000000537DOI Listing
May 2019
1 Read

Iodinated Contrast Agents and Risk of Hypothyroidism in Young Children in the United States.

Invest Radiol 2019 May;54(5):296-301

Epidemiology, Division of Pharmaceuticals, Bayer Consumer Care AG, Basel, Switzerland.

Background: Although it is generally acknowledged that exposure to iodine contrast agents can interfere with thyroid function, little is known about the incidence of iodine-induced hypothyroidism in young children (younger than the age of 4 years).

Study Objectives: This was a retrospective cohort study to estimate the incidence rate of detected hypothyroidism in a US-based general population of pediatric patients exposed to an iodinated contrast agent.

Setting: The study was conducted in Kaiser Permanente Northern California, an integrated health care delivery system. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/RLI.0000000000000541DOI Listing
May 2019
1 Read
4.437 Impact Factor

Futile Recanalization With Poor Clinical Outcome Is Associated With Increased Edema Volume After Ischemic Stroke.

Invest Radiol 2019 May;54(5):282-287

From the Department of Diagnostic and Interventional Neuroradiology, and.

Purpose: Futile recanalization with poor clinical outcome after endovascular treatment of acute ischemic stroke is poorly understood. Recently, vessel recanalization has been associated with reduced ischemic brain edema in patients with good clinical outcome. As edema volume (EV) may be quantified in computed tomography (CT), we hypothesized that higher EV after revascularization predicts futile recanalization with poor outcome. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/RLI.0000000000000539DOI Listing
May 2019
21 Reads

Reduction of Metal Artifacts and Improvement in Dose Efficiency Using Photon-Counting Detector Computed Tomography and Tin Filtration.

Invest Radiol 2019 Apr;54(4):204-211

Health Sciences Research, Mayo Clinic, Jacksonville, FL.

Objectives: The aim of this study was to investigate the impact on metal artifacts and dose efficiency of using a tin filter in combination with high-energy threshold (TH) images of a photon-counting detector (PCD) computed tomography (CT) system.

Materials And Methods: A 3D-printed spine with pedicle screws was scanned on a PCD-CT system with and without tin filtration. Image noise and severity of artifacts were measured for low-energy threshold (TL) and TH images. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/RLI.0000000000000535DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434693PMC
April 2019
2 Reads

Glymphatic Pathway of Gadolinium-Based Contrast Agents Through the Brain: Overlooked and Misinterpreted.

Invest Radiol 2019 Apr;54(4):229-237

Department of Diagnostic and Interventional Radiology and Neuroradiology, University Essen, Essen.

Background: The "glymphatic system" (GS), a brain-wide network of cerebrospinal fluid microcirculation, supplies a pathway through and out of the central nervous system (CNS); malfunction of the system is implicated in a variety of neurological disorders. In this exploratory study, we analyzed the potential of a new imaging approach that we coined delayed T2-weighted gadolinium-enhanced imaging to visualize the GS in vivo.

Methods: Heavily T2-weighted fluid-attenuated inversion recovery (hT2w-FLAIR) magnetic resonance imaging was obtained before, and 3 hours and 24 hours after intravenous gadolinium-based contrast agent (GBCA) application in 33 neurologically healthy patients and 7 patients with an impaired blood-brain barrier (BBB) due to cerebral metastases. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/RLI.0000000000000533DOI Listing
April 2019
30 Reads

Negligible Risk of Acute Renal Failure Among Hospitalized Patients After Contrast-Enhanced Imaging With Iodinated Versus Gadolinium-Based Agents.

Invest Radiol 2019 May;54(5):312-318

Institute of Endocrinology, Diabetes & Metabolism, Rambam Health Care Campus, Haifa.

Introduction: The potential adverse renal outcome among patients undergoing iodine-based contrast-enhanced computerized tomography (CT) has been questioned recently, given the caution undertaken in patients' selection, hydration protocols, and the low radiocontrast volume, used with advanced imaging equipment.

Materials And Methods: This study is a retrospective assessment of renal outcome in 12,580 hospitalized patients undergoing contrast-enhanced CT, compared with 754 patients subjected to gadolinium-based magnetic resonance imaging, with subsequent propensity matching for clinical characteristics and potential risk factors.

Results: The risk of postcontrast acute kidney injury (PC-AKI) was found to be negligible as compared with patients undergoing enhanced magnetic resonance imaging studies, before and after propensity matching (8% vs 7. Read More

View Article

Download full-text PDF

Source
http://Insights.ovid.com/crossref?an=00004424-900000000-9895
Publisher Site
http://dx.doi.org/10.1097/RLI.0000000000000534DOI Listing
May 2019
28 Reads

High-Resolution Chest Computed Tomography Imaging of the Lungs: Impact of 1024 Matrix Reconstruction and Photon-Counting Detector Computed Tomography.

Invest Radiol 2019 Mar;54(3):129-137

Siemens Healthineers, Malvern, PA.

Objectives: The aim of this study was to evaluate if a high-resolution photon-counting detector computed tomography (PCD-CT) system with a 1024×1024 matrix reconstruction can improve the visualization of fine structures in the lungs compared with conventional high-resolution CT (HRCT).

Materials And Methods: Twenty-two adult patients referred for clinical chest HRCT (mean CTDI vol, 13.58 mGy) underwent additional dose-matched PCD-CT (mean volume CT dose index, 13. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/RLI.0000000000000524DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363870PMC
March 2019
20 Reads

Tomoelastography for the Evaluation of Pediatric Nonalcoholic Fatty Liver Disease.

Invest Radiol 2019 Apr;54(4):198-203

the Departments of Radiology.

Objectives: Today, nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in children and adults alike. Yet, the noninvasive evaluation of disease severity remains a diagnostic challenge. In this study, we apply multifrequency magnetic resonance elastography (mMRE) for the quantification of liver steatosis and fibrosis in adolescents with NAFLD. Read More

View Article

Download full-text PDF

Source
http://Insights.ovid.com/crossref?an=00004424-900000000-9895
Publisher Site
http://dx.doi.org/10.1097/RLI.0000000000000529DOI Listing
April 2019
14 Reads

Advanced Robotic Angiography Systems for Image Guidance During Conventional Transarterial Chemoembolization: Impact on Radiation Dose and Image Quality.

Invest Radiol 2019 Mar;54(3):153-159

Department of Radiology and Radiological Science, Medical University of South Carolina, Charleston, SC.

Objectives: The aim of this study was to compare 2 advanced robotic angiography systems for real-time image guidance in terms of radiation dose and image quality (IQ) during conventional transarterial chemoembolization (C-TACE) of hepatic malignant tumors.

Materials And Methods: One hundred six patients (57 women/49 men; mean age, 60 ± 11 years) who had undergone C-TACE using 2 generations of robotic angiography platforms for image guidance were included in this retrospective study. Patients were divided into 2 groups (n = 53, respectively): group 1 (first generation) and group 2 (second generation). Read More

View Article

Download full-text PDF

Source
http://Insights.ovid.com/crossref?an=00004424-900000000-9895
Publisher Site
http://dx.doi.org/10.1097/RLI.0000000000000519DOI Listing
March 2019
14 Reads

T1- and T2*-Mapping for Assessment of Tendon Tissue Biophysical Properties: A Phantom MRI Study.

Invest Radiol 2019 Apr;54(4):212-220

Department of Radiology, Balgrist University Hospital.

Objectives: The aim of this study was to quantitatively assess changes in collagen structure using MR T1- and T2*-mapping in a novel controlled ex vivo tendon model setup.

Materials And Methods: Twenty-four cadaveric bovine flexor tendons underwent MRI at 3 T before and after chemical modifications, representing mechanical degeneration and augmentation. Collagen degradation (COL), augmenting collagen fiber cross-linking (CXL), and a control (phosphate-buffered saline [PBS]) were examined in experimental groups, using histopathology as standard of reference. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/RLI.0000000000000532DOI Listing
April 2019
17 Reads

7 T Magnetic Resonance Spectroscopic Imaging in Multiple Sclerosis: How Does Spatial Resolution Affect the Detectability of Metabolic Changes in Brain Lesions?

Invest Radiol 2019 Apr;54(4):247-254

Christian Doppler Laboratory for Clinical Molecular MR Imaging, Vienna, Austria.

Objectives: The aim of this study was to assess the utility of increased spatial resolution of magnetic resonance spectroscopic imaging (MRSI) at 7 T for the detection of neurochemical changes in multiple sclerosis (MS)-related brain lesions.

Materials And Methods: This prospective, institutional review board-approved study was performed in 20 relapsing-remitting MS patients (9 women/11 men; mean age ± standard deviation, 30.8 ± 7. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/RLI.0000000000000531DOI Listing
April 2019
16 Reads

Robustness and Reproducibility of Radiomics in Magnetic Resonance Imaging: A Phantom Study.

Invest Radiol 2019 Apr;54(4):221-228

Philips Healthcare Hamburg, Hamburg, Germany.

Objectives: The aim of this study was to investigate the robustness and reproducibility of radiomic features in different magnetic resonance imaging sequences.

Materials And Methods: A phantom was scanned on a clinical 3 T system using fluid-attenuated inversion recovery (FLAIR), T1-weighted (T1w), and T2-weighted (T2w) sequences with low and high matrix size. For retest data, scans were repeated after repositioning of the phantom. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/RLI.0000000000000530DOI Listing
April 2019
1 Read

Prediction of Lumbar Disk Herniation and Clinical Outcome Using Quantitative Magnetic Resonance Imaging: A 5-Year Follow-Up Study.

Invest Radiol 2019 Mar;54(3):183-189

High-Field MR Centre, Department of Biomedical Imaging and Image-Guided Therapy, and.

Objectives: The aim of this study was to assess the predictive value of T2 mapping at baseline with regard to the development of disk herniation and clinical outcome at a 5-year follow-up in patients with low back pain.

Materials And Methods: Twenty-five symptomatic patients (13 male; mean age, 44.0 years; range, 24-64 years at baseline) were examined at 3 T magnetic resonance imaging, with a 5-year follow-up. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/RLI.0000000000000527DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396874PMC
March 2019
16 Reads

Clinical Magnetic Resonance Imaging of the Knee at 7 T: Optimization of Fat Suppression.

Invest Radiol 2019 Mar;54(3):160-168

Institute for Diagnostic and Interventional Radiology, University Hospital of Zurich.

Purpose: The aim of this study was to evaluate the efficiency and performance of different fat suppression techniques for clinical 7 T knee magnetic resonance imaging including the slice-selective gradient reversal (SSGR) technique.

Materials And Methods: This article is an ethical board-approved prospective study with written informed consent from 8 volunteers (mean, 31 ± 4 years). It included fat phantom and knee magnetic resonance imaging at 3 T (Magnetom Skyra; Siemens Healthcare) and at 7 T (Achieva, Philips Healthcare). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/RLI.0000000000000523DOI Listing
March 2019
14 Reads

Does Age Interfere With Gadolinium Toxicity and Presence in Brain and Bone Tissues?: A Comparative Gadoterate Versus Gadodiamide Study in Juvenile and Adult Rats.

Invest Radiol 2019 Feb;54(2):61-71

Atlantic Bone Screen, Saint Herblain, France.

Objectives: The main objective of the study was to assess the effect of age on target tissue total gadolinium (Gd) retention after repeated administration of gadodiamide (linear) or gadoterate (macrocyclic) Gd-based contrast agent (GBCA) in rats. The secondary objective was to assess the potential developmental and long-term consequences of GBCA administration during neonatal and juvenile periods.

Materials And Methods: A total of 20 equivalent human clinical doses (cumulated dose, 12 mmol Gd/kg) of either gadoterate or gadodiamide were administered concurrently by the intravenous route to healthy adult and juvenile rats. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/RLI.0000000000000517DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310471PMC
February 2019
20 Reads

The Impact of Different Magnetic Resonance Imaging Equipment and Scanning Parameters on Signal Intensity Ratio Measurements in Phantoms and Healthy Volunteers: Implications for Interpreting Gadolinium Signal Changes Within the Brain.

Invest Radiol 2019 Mar;54(3):169-176

Clinical Radiology, NHS Tayside, Ninewells Hospital and Medical School, Dundee, United Kingdom.

Objectives: The aim of this study was to examine the variation in signal intensity ratio (SIR) values in Eurospin gel phantoms and healthy volunteer (HV) brain images in response to different magnetic resonance imaging hardware and software settings.

Materials And Methods: Gel phantoms with T1 relaxation times similar to the dentate nucleus (DN), pons (P), globus palladus (GP), and thalamus (Th) were scanned using a T1-weighted 2-dimensional spin-echo sequence on 2 magnetic resonance imaging scanners (3 T and 1.5 T). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/RLI.0000000000000526DOI Listing
March 2019
1 Read

T2 Mapping in Prostate Cancer.

Invest Radiol 2019 Mar;54(3):146-152

From the Department of Radiology, University Hospital Jena, Jena, Germany.

Objectives: The aim of the study was to determine the quantitative T2 values in prostate tissue and evaluate them for detection and grading of prostate cancer.

Materials And Methods: After approval from the local ethics committee, morphological T2-weighted (T2w) images, apparent diffusion coefficient (ADC) maps from diffusion-weighted images, quantitative T2 maps, and calculated T2w images from 75 men (median age, 66.3 years; median PSA, 8. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/RLI.0000000000000520DOI Listing
March 2019
14 Reads

A Structured Survey on Adverse Events Occurring Within 24 Hours After Intravenous Exposure to Gadodiamide or Gadoterate Meglumine: A Controlled Prospective Comparison Study.

Invest Radiol 2019 Apr;54(4):191-197

From the Departmental Faculty of Medicine and Surgery, Università Campus Bio-Medico di Roma, Rome, Italy.

Objective: This study compares the incidence of new-onset symptoms within 24 hours after enhanced magnetic resonance imaging (eMRI) with intravenous administration of gadodiamide or gadoterate meglumine compared with a control group undergoing unenhanced MRI (uMRI).

Materials And Methods: A prospective cohort study (n = 1088 patients) was designed to assess the incidence of symptoms within 24 hours after administration of gadodiamide or gadoterate meglumine. The participants underwent a structured questionnaire by phone call before and 24 hours after the MRI scan to check for symptoms that were not present before the scan. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/RLI.0000000000000528DOI Listing
April 2019
1 Read

Personalized 3D-Printed Transparent Liver Model Using the Hepatobiliary Phase MRI: Usefulness in the Lesion-by-Lesion Imaging-Pathologic Matching of Focal Liver Lesions-Preliminary Results.

Invest Radiol 2019 Mar;54(3):138-145

Department of Radiology, Seoul National University College of Medicine.

Purpose: The aim of this study was to investigate the usefulness of a personalized, 3-dimensional (3D)-printed, transparent liver model with focal liver lesions (FLLs) for lesion-by-lesion imaging-pathologic matching.

Materials And Methods: This preliminary, prospective study was approved by our institutional review board, and written informed consent was obtained. Twenty patients (male-to-female ratio, 13:7; mean age, 56 years) with multiple FLLs, including at least one presumed malignant, or an indeterminate lesion 10 mm or less on the preoperative gadoxetic acid-enhanced magnetic resonance imaging (MRI), were included. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/RLI.0000000000000521DOI Listing
March 2019
11 Reads

Native T1 Mapping as an In Vivo Biomarker for the Identification of Higher-Grade Renal Cell Carcinoma: Correlation With Histopathological Findings.

Invest Radiol 2019 Feb;54(2):118-128

Departments of Radiology.

Objectives: The aims of this study were to identify higher-grade clear cell renal cell carcinoma (cRCC) with native T1 mapping and to histologically correlate the results with the collagen volume fraction.

Materials And Methods: For this institutional review board-approved, single-center prospective study, 68 consecutive patients received abdominal magnetic resonance imaging scans at 1.5 T between January 2017 and July 2018, using a Modified Look-Locker Inversion Recovery (MOLLI) sequence. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/RLI.0000000000000515DOI Listing
February 2019
6 Reads

Impact of Treatment With Chelating Agents Depends on the Stability of Administered GBCAs: A Comparative Study in Rats.

Invest Radiol 2019 Feb;54(2):76-82

MR and CT Contrast Media Research, Bayer AG, Berlin, Germany.

Objective: This study investigated the potential effect of the chelating agent calcium trisodium pentetate (Ca-DTPA) on the urinary excretion of gadolinium and the subsequent elimination of gadolinium (Gd) in the brain after a single intravenous administration of either a linear (gadodiamide) or a macrocyclic (gadobutrol) Gd-based contrast agent in rats.

Materials And Methods: Rats received either a single injection of gadodiamide or gadobutrol (1.8 mmol/kg, each) or saline (n = 18 per group). Read More

View Article

Download full-text PDF

Source
http://Insights.ovid.com/crossref?an=00004424-900000000-9896
Publisher Site
http://dx.doi.org/10.1097/RLI.0000000000000522DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310454PMC
February 2019
4 Reads