6,411 results match your criteria Investigative Radiology[Journal]


Compressed Sensing and Parallel Imaging for Double Hepatic Arterial Phase Acquisition in Gadoxetate-Enhanced Dynamic Liver Magnetic Resonance Imaging.

Invest Radiol 2019 Feb 1. Epub 2019 Feb 1.

From the Department of Radiology, Research Institute of Radiological Science, Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea.

Objectives: The aim of this study was to investigate the utility of a combined compressed sensing and parallel imaging (C-SENSE) technique for single breath-hold, double arterial phase (AP) examinations in gadoxetate-enhanced magnetic resonance imaging (MRI) of the liver.

Materials And Methods: We retrospectively reviewed single breath-hold, double AP images obtained by using a C-SENSE technique for gadoxetate-enhanced dynamic liver MRI in a total of 127 patients (89 men and 38 women; mean age, 62.6 ± 7. Read More

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http://dx.doi.org/10.1097/RLI.0000000000000548DOI Listing
February 2019
1 Read
4.437 Impact Factor

The Impact of Echo Time Shifts and Temporal Signal Fluctuations on BOLD Sensitivity in Presurgical Planning at 7 T.

Invest Radiol 2019 Feb 1. Epub 2019 Feb 1.

Study Group Clinical fMRI, Department of Neurology, Medical University of Vienna, Vienna.

Objectives: Gradients in the static magnetic field caused by tissues with differing magnetic susceptibilities lead to regional variations in the effective echo time, which modifies both image signal and BOLD sensitivity. Local echo time changes are not considered in the most commonly used metric for BOLD sensitivity, temporal signal-to-noise ratio (tSNR), but may be significant, particularly at ultrahigh field close to air cavities (such as the sinuses and ear canals) and near gross brain pathologies and postoperative sites.

Materials And Methods: We have studied the effect of local variations in echo time and tSNR on BOLD sensitivity in 3 healthy volunteers and 11 patients with tumors, postoperative cavities, and venous malformations at 7 T. Read More

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http://dx.doi.org/10.1097/RLI.0000000000000546DOI Listing
February 2019

Individually Body Weight-Adapted Contrast Media Application in Computed Tomography Imaging of the Liver at 90 kVp.

Invest Radiol 2019 Mar;54(3):177-182

From the Department of Radiology and Nuclear Medicine; and CARIM School for Cardiovascular Diseases, Maastricht University Medical Center, Maastricht, the Netherlands.

Objectives: The aim of the present study was to evaluate the attenuation and image quality (IQ) of a body weight-adapted contrast media (CM) protocol compared with a fixed injection protocol in computed tomography (CT) of the liver at 90 kV.

Materials And Methods: One hundred ninety-nine consecutive patients referred for abdominal CT imaging in portal venous phase were included. Group 1 (n = 100) received a fixed CM dose with a total iodine load (TIL) of 33 g I at a flow rate of 3. Read More

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http://dx.doi.org/10.1097/RLI.0000000000000525DOI Listing
March 2019
1 Read

Acceleration of Double Inversion Recovery Sequences in Multiple Sclerosis With Compressed Sensing.

Invest Radiol 2019 Jan 31. Epub 2019 Jan 31.

Department of Neurology, and.

Objective: The aim of this study was to assess the performance of double inversion recovery (DIR) sequences accelerated by compressed sensing (CS) in a clinical setting.

Materials And Methods: We included 106 patients with MS (62 female [58%]; mean age, 44.9 ± 11. Read More

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http://dx.doi.org/10.1097/RLI.0000000000000550DOI Listing
January 2019
1 Read

Ultrashort Time to Echo Magnetic Resonance Evaluation of Calcium Pyrophosphate Crystal Deposition in Human Menisci.

Invest Radiol 2019 Jan 25. Epub 2019 Jan 25.

Department of Radiology, VA San Diego Healthcare System, San Diego, CA.

Objectives: In human menisci, we aimed to investigate whether calcium pyrophosphate crystal deposition (CPPD) affects biomechanical and quantitative MR properties, and their zonal distribution.

Materials And Methods: From 9 cadaveric knees, sectioned triangular meniscus pieces were harvested. Samples were classified into "normal" or "CPPD" groups based upon visual inspection. Read More

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http://dx.doi.org/10.1097/RLI.0000000000000547DOI Listing
January 2019

Longitudinal Visualization of Viable Cancer Cell Intratumoral Distribution in Mouse Models Using Oatp1a1-Enhanced Magnetic Resonance Imaging.

Invest Radiol 2019 Jan 21. Epub 2019 Jan 21.

Medical Imaging Laboratories, Robarts Research Institute, London, Ontario.

Objectives: Multimodality reporter gene imaging provides valuable, noninvasive information on the fate of engineered cell populations. To complement magnetic resonance imaging (MRI) measures of tumor volume and 2-dimensional reporter-based optical measures of cell viability, reporter-based MRI may offer 3-dimensional information on the distribution of viable cancer cells in deep tissues.

Materials And Methods: Here, we engineered human and murine triple-negative breast cancer cells with lentivirus encoding tdTomato and firefly luciferase for fluorescence imaging and bioluminescence imaging (BLI). Read More

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http://dx.doi.org/10.1097/RLI.0000000000000542DOI Listing
January 2019

Instant Outcome Evaluation of Microwave Ablation With Subtraction CT in an In Vivo Porcine Model.

Invest Radiol 2019 Jan 15. Epub 2019 Jan 15.

From the Departments of Radiology, and.

Objectives: The aim of this study was to investigate whether the accuracy of multislice contrast-enhanced computed tomography (MS-CECT) may be improved by performing additional subtraction CT.

Materials And Methods: Thirty-five microwave ablations were performed under CT guidance in 12 healthy and anesthetized pigs. Preablation and postablation MS-CECT scans were obtained in arterial and venous contrast phases. Read More

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http://dx.doi.org/10.1097/RLI.0000000000000545DOI Listing
January 2019
1 Read

Artificial Intelligence-Based Classification of Breast Lesions Imaged With a Multiparametric Breast MRI Protocol With Ultrafast DCE-MRI, T2, and DWI.

Invest Radiol 2019 Jan 15. Epub 2019 Jan 15.

From the Departments of Radiology and Nuclear Medicine, and.

Objectives: We investigated artificial intelligence (AI)-based classification of benign and malignant breast lesions imaged with a multiparametric breast magnetic resonance imaging (MRI) protocol with ultrafast dynamic contrast-enhanced MRI, T2-weighted, and diffusion-weighted imaging with apparent diffusion coefficient mapping.

Materials And Methods: We analyzed 576 lesions imaged with MRI, including a consecutive set of biopsied malignant (368) and benign (149) lesions, and an additional set of 59 benign lesions proven by follow-up. We used deep learning methods to interpret ultrafast dynamic contrast-enhanced MRI and T2-weighted information. Read More

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http://dx.doi.org/10.1097/RLI.0000000000000544DOI Listing
January 2019
3 Reads

Quantitative Multiparametric Breast Ultrasound: Application of Contrast-Enhanced Ultrasound and Elastography Leads to an Improved Differentiation of Benign and Malignant Lesions.

Invest Radiol 2019 Jan 10. Epub 2019 Jan 10.

Memorial Sloan-Kettering Cancer Center, Department of Radiology, Molecular Imaging and Therapy Service, New York, NY.

Objectives: The aim of this study was to evaluate breast multiparametric ultrasound (mpUS) and its potential to reduce unnecessary breast biopsies with 1, 2, or 3 additional quantitative parameters (Doppler, elastography, and contrast-enhanced ultrasound [CEUS]) to B-mode and investigate possible variations with different reader experience.

Materials And Methods: This prospective study included 124 women (age range, 18-82 years; mean, 52 years), each with 1 new breast lesion, scheduled for ultrasound-guided biopsy between October 2015 and September 2016. Each lesion was examined with B-mode, elastography (Virtual Touch IQ [VTIQ]), Doppler, and CEUS, and different quantitative parameters were recorded for each modality. Read More

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http://dx.doi.org/10.1097/RLI.0000000000000543DOI Listing
January 2019
5 Reads

Accelerated Segmented Diffusion-Weighted Prostate Imaging for Higher Resolution, Higher Geometric Fidelity, and Multi-b Perfusion Estimation.

Invest Radiol 2018 Dec 19. Epub 2018 Dec 19.

Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

Purpose: The aim of this study was to improve the geometric fidelity and spatial resolution of multi-b diffusion-weighted magnetic resonance imaging of the prostate.

Materials And Methods: An accelerated segmented diffusion imaging sequence was developed and evaluated in 25 patients undergoing multiparametric magnetic resonance imaging examinations of the prostate. A reduced field of view was acquired using an endorectal coil. Read More

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http://dx.doi.org/10.1097/RLI.0000000000000536DOI Listing
December 2018

Matching and Homogenizing Convolution Kernels for Quantitative Studies in Computed Tomography.

Invest Radiol 2018 Dec 18. Epub 2018 Dec 18.

Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston.

The sharpness of the kernels used for image reconstruction in computed tomography affects the values of the quantitative image features. We sought to identify the kernels that produce similar feature values to enable a more effective comparison of images produced using scanners from different manufactures. We also investigated a new image filter designed to change the kernel-related component of the frequency spectrum of a postreconstruction image from that of the initial kernel to that of a preferred kernel. Read More

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http://dx.doi.org/10.1097/RLI.0000000000000540DOI Listing
December 2018
1 Read

Low-Dose Perfusion Computed Tomography for Breast Cancer to Quantify Tumor Vascularity: Correlation With Prognostic Biomarkers.

Invest Radiol 2018 Dec 18. Epub 2018 Dec 18.

Division of Breast and Endocrine Surgery, Department of Surgery, Korea University Ansan Hospital, Korea University College of Medicine, Gyeonggi-do, Republic of Korea.

Objectives: The aim of this study was to investigate the feasibility of using low-dose perfusion computed tomography (CT) in breast cancers for quantification of tumor vascularity and to correlate perfusion indexes with prognostic biomarkers.

Materials And Methods: This preliminary study was approved by our institutional review board. Signed informed consent was obtained from all 70 enrolled patients with invasive breast cancers. Read More

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http://dx.doi.org/10.1097/RLI.0000000000000538DOI Listing
December 2018
6 Reads

Automatic Tube Current Modulation and Tube Voltage Selection in Pediatric Computed Tomography: A Phantom Study on Radiation Dose and Image Quality.

Invest Radiol 2018 Dec 17. Epub 2018 Dec 17.

Medical Physics Department, University of Crete, Stavrakia, Crete, Greece.

Objectives: The aim of this study was to investigate the effects of a modern automatic tube current modulation (ATCM) and automatic tube voltage selection (ATVS) system on radiation dose and image quality in pediatric head, and torso computed tomography (CT) examinations for various clinical indications.

Materials And Methods: Four physical anthropomorphic phantoms that represent the average individual as neonate, 1-year-old, 5-year-old, and 10-year-old child were used. Standard head, thorax, and abdomen/pelvis acquisitions were performed with (1) fixed tube current, (2) ATCM, and (3) ATVS. Read More

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http://dx.doi.org/10.1097/RLI.0000000000000537DOI Listing
December 2018

Iodinated Contrast Agents and Risk of Hypothyroidism in Young Children in the United States.

Invest Radiol 2018 Dec 17. Epub 2018 Dec 17.

Epidemiology, Division of Pharmaceuticals, Bayer Consumer Care AG, Basel, Switzerland.

Background: Although it is generally acknowledged that exposure to iodine contrast agents can interfere with thyroid function, little is known about the incidence of iodine-induced hypothyroidism in young children (younger than the age of 4 years).

Study Objectives: This was a retrospective cohort study to estimate the incidence rate of detected hypothyroidism in a US-based general population of pediatric patients exposed to an iodinated contrast agent.

Setting: The study was conducted in Kaiser Permanente Northern California, an integrated health care delivery system. Read More

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http://dx.doi.org/10.1097/RLI.0000000000000541DOI Listing
December 2018
4.437 Impact Factor

Futile Recanalization With Poor Clinical Outcome Is Associated With Increased Edema Volume After Ischemic Stroke.

Invest Radiol 2018 Dec 17. Epub 2018 Dec 17.

From the Department of Diagnostic and Interventional Neuroradiology, and.

Purpose: Futile recanalization with poor clinical outcome after endovascular treatment of acute ischemic stroke is poorly understood. Recently, vessel recanalization has been associated with reduced ischemic brain edema in patients with good clinical outcome. As edema volume (EV) may be quantified in computed tomography (CT), we hypothesized that higher EV after revascularization predicts futile recanalization with poor outcome. Read More

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http://dx.doi.org/10.1097/RLI.0000000000000539DOI Listing
December 2018
16 Reads

Reduction of Metal Artifacts and Improvement in Dose Efficiency Using Photon-Counting Detector Computed Tomography and Tin Filtration.

Invest Radiol 2018 Dec 17. Epub 2018 Dec 17.

Health Sciences Research, Mayo Clinic, Jacksonville, FL.

Objectives: The aim of this study was to investigate the impact on metal artifacts and dose efficiency of using a tin filter in combination with high-energy threshold (TH) images of a photon-counting detector (PCD) computed tomography (CT) system.

Materials And Methods: A 3D-printed spine with pedicle screws was scanned on a PCD-CT system with and without tin filtration. Image noise and severity of artifacts were measured for low-energy threshold (TL) and TH images. Read More

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http://dx.doi.org/10.1097/RLI.0000000000000535DOI Listing
December 2018
1 Read

Glymphatic Pathway of Gadolinium-Based Contrast Agents Through the Brain: Overlooked and Misinterpreted.

Invest Radiol 2018 Nov 21. Epub 2018 Nov 21.

Department of Diagnostic and Interventional Radiology and Neuroradiology, University Essen, Essen.

Background: The "glymphatic system" (GS), a brain-wide network of cerebrospinal fluid microcirculation, supplies a pathway through and out of the central nervous system (CNS); malfunction of the system is implicated in a variety of neurological disorders. In this exploratory study, we analyzed the potential of a new imaging approach that we coined delayed T2-weighted gadolinium-enhanced imaging to visualize the GS in vivo.

Methods: Heavily T2-weighted fluid-attenuated inversion recovery (hT2w-FLAIR) magnetic resonance imaging was obtained before, and 3 hours and 24 hours after intravenous gadolinium-based contrast agent (GBCA) application in 33 neurologically healthy patients and 7 patients with an impaired blood-brain barrier (BBB) due to cerebral metastases. Read More

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http://dx.doi.org/10.1097/RLI.0000000000000533DOI Listing
November 2018
17 Reads

Negligible Risk of Acute Renal Failure Among Hospitalized Patients After Contrast-Enhanced Imaging With Iodinated Versus Gadolinium-Based Agents.

Invest Radiol 2018 Nov 21. Epub 2018 Nov 21.

Institute of Endocrinology, Diabetes & Metabolism, Rambam Health Care Campus, Haifa.

Introduction: The potential adverse renal outcome among patients undergoing iodine-based contrast-enhanced computerized tomography (CT) has been questioned recently, given the caution undertaken in patients' selection, hydration protocols, and the low radiocontrast volume, used with advanced imaging equipment.

Materials And Methods: This study is a retrospective assessment of renal outcome in 12,580 hospitalized patients undergoing contrast-enhanced CT, compared with 754 patients subjected to gadolinium-based magnetic resonance imaging, with subsequent propensity matching for clinical characteristics and potential risk factors.

Results: The risk of postcontrast acute kidney injury (PC-AKI) was found to be negligible as compared with patients undergoing enhanced magnetic resonance imaging studies, before and after propensity matching (8% vs 7. Read More

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http://dx.doi.org/10.1097/RLI.0000000000000534DOI Listing
November 2018
16 Reads

High-Resolution Chest Computed Tomography Imaging of the Lungs: Impact of 1024 Matrix Reconstruction and Photon-Counting Detector Computed Tomography.

Invest Radiol 2019 Mar;54(3):129-137

Siemens Healthineers, Malvern, PA.

Objectives: The aim of this study was to evaluate if a high-resolution photon-counting detector computed tomography (PCD-CT) system with a 1024×1024 matrix reconstruction can improve the visualization of fine structures in the lungs compared with conventional high-resolution CT (HRCT).

Materials And Methods: Twenty-two adult patients referred for clinical chest HRCT (mean CTDI vol, 13.58 mGy) underwent additional dose-matched PCD-CT (mean volume CT dose index, 13. Read More

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http://dx.doi.org/10.1097/RLI.0000000000000524DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363870PMC
March 2019
14 Reads

Tomoelastography for the Evaluation of Pediatric Nonalcoholic Fatty Liver Disease.

Invest Radiol 2018 Nov 15. Epub 2018 Nov 15.

the Departments of Radiology.

Objectives: Today, nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in children and adults alike. Yet, the noninvasive evaluation of disease severity remains a diagnostic challenge. In this study, we apply multifrequency magnetic resonance elastography (mMRE) for the quantification of liver steatosis and fibrosis in adolescents with NAFLD. Read More

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http://Insights.ovid.com/crossref?an=00004424-900000000-9895
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http://dx.doi.org/10.1097/RLI.0000000000000529DOI Listing
November 2018
8 Reads

Advanced Robotic Angiography Systems for Image Guidance During Conventional Transarterial Chemoembolization: Impact on Radiation Dose and Image Quality.

Invest Radiol 2019 Mar;54(3):153-159

Department of Radiology and Radiological Science, Medical University of South Carolina, Charleston, SC.

Objectives: The aim of this study was to compare 2 advanced robotic angiography systems for real-time image guidance in terms of radiation dose and image quality (IQ) during conventional transarterial chemoembolization (C-TACE) of hepatic malignant tumors.

Materials And Methods: One hundred six patients (57 women/49 men; mean age, 60 ± 11 years) who had undergone C-TACE using 2 generations of robotic angiography platforms for image guidance were included in this retrospective study. Patients were divided into 2 groups (n = 53, respectively): group 1 (first generation) and group 2 (second generation). Read More

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http://dx.doi.org/10.1097/RLI.0000000000000519DOI Listing
March 2019
10 Reads

T1- and T2*-Mapping for Assessment of Tendon Tissue Biophysical Properties: A Phantom MRI Study.

Invest Radiol 2018 Nov 16. Epub 2018 Nov 16.

Department of Radiology, Balgrist University Hospital.

Objectives: The aim of this study was to quantitatively assess changes in collagen structure using MR T1- and T2*-mapping in a novel controlled ex vivo tendon model setup.

Materials And Methods: Twenty-four cadaveric bovine flexor tendons underwent MRI at 3 T before and after chemical modifications, representing mechanical degeneration and augmentation. Collagen degradation (COL), augmenting collagen fiber cross-linking (CXL), and a control (phosphate-buffered saline [PBS]) were examined in experimental groups, using histopathology as standard of reference. Read More

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http://dx.doi.org/10.1097/RLI.0000000000000532DOI Listing
November 2018
13 Reads

7 T Magnetic Resonance Spectroscopic Imaging in Multiple Sclerosis: How Does Spatial Resolution Affect the Detectability of Metabolic Changes in Brain Lesions?

Invest Radiol 2018 Nov 14. Epub 2018 Nov 14.

Christian Doppler Laboratory for Clinical Molecular MR Imaging, Vienna, Austria.

Objectives: The aim of this study was to assess the utility of increased spatial resolution of magnetic resonance spectroscopic imaging (MRSI) at 7 T for the detection of neurochemical changes in multiple sclerosis (MS)-related brain lesions.

Materials And Methods: This prospective, institutional review board-approved study was performed in 20 relapsing-remitting MS patients (9 women/11 men; mean age ± standard deviation, 30.8 ± 7. Read More

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http://dx.doi.org/10.1097/RLI.0000000000000531DOI Listing
November 2018
10 Reads

Robustness and Reproducibility of Radiomics in Magnetic Resonance Imaging: A Phantom Study.

Invest Radiol 2018 Nov 14. Epub 2018 Nov 14.

Philips Healthcare Hamburg, Hamburg, Germany.

Objectives: The aim of this study was to investigate the robustness and reproducibility of radiomic features in different magnetic resonance imaging sequences.

Materials And Methods: A phantom was scanned on a clinical 3 T system using fluid-attenuated inversion recovery (FLAIR), T1-weighted (T1w), and T2-weighted (T2w) sequences with low and high matrix size. For retest data, scans were repeated after repositioning of the phantom. Read More

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http://dx.doi.org/10.1097/RLI.0000000000000530DOI Listing
November 2018

Prediction of Lumbar Disk Herniation and Clinical Outcome Using Quantitative Magnetic Resonance Imaging: A 5-Year Follow-Up Study.

Invest Radiol 2019 Mar;54(3):183-189

High-Field MR Centre, Department of Biomedical Imaging and Image-Guided Therapy, and.

Objectives: The aim of this study was to assess the predictive value of T2 mapping at baseline with regard to the development of disk herniation and clinical outcome at a 5-year follow-up in patients with low back pain.

Materials And Methods: Twenty-five symptomatic patients (13 male; mean age, 44.0 years; range, 24-64 years at baseline) were examined at 3 T magnetic resonance imaging, with a 5-year follow-up. Read More

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http://dx.doi.org/10.1097/RLI.0000000000000527DOI Listing
March 2019
8 Reads

Clinical Magnetic Resonance Imaging of the Knee at 7 T: Optimization of Fat Suppression.

Invest Radiol 2019 Mar;54(3):160-168

Institute for Diagnostic and Interventional Radiology, University Hospital of Zurich.

Purpose: The aim of this study was to evaluate the efficiency and performance of different fat suppression techniques for clinical 7 T knee magnetic resonance imaging including the slice-selective gradient reversal (SSGR) technique.

Materials And Methods: This article is an ethical board-approved prospective study with written informed consent from 8 volunteers (mean, 31 ± 4 years). It included fat phantom and knee magnetic resonance imaging at 3 T (Magnetom Skyra; Siemens Healthcare) and at 7 T (Achieva, Philips Healthcare). Read More

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http://dx.doi.org/10.1097/RLI.0000000000000523DOI Listing
March 2019
9 Reads

Does Age Interfere With Gadolinium Toxicity and Presence in Brain and Bone Tissues?: A Comparative Gadoterate Versus Gadodiamide Study in Juvenile and Adult Rats.

Invest Radiol 2019 Feb;54(2):61-71

Atlantic Bone Screen, Saint Herblain, France.

Objectives: The main objective of the study was to assess the effect of age on target tissue total gadolinium (Gd) retention after repeated administration of gadodiamide (linear) or gadoterate (macrocyclic) Gd-based contrast agent (GBCA) in rats. The secondary objective was to assess the potential developmental and long-term consequences of GBCA administration during neonatal and juvenile periods.

Materials And Methods: A total of 20 equivalent human clinical doses (cumulated dose, 12 mmol Gd/kg) of either gadoterate or gadodiamide were administered concurrently by the intravenous route to healthy adult and juvenile rats. Read More

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http://dx.doi.org/10.1097/RLI.0000000000000517DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310471PMC
February 2019
11 Reads

The Impact of Different Magnetic Resonance Imaging Equipment and Scanning Parameters on Signal Intensity Ratio Measurements in Phantoms and Healthy Volunteers: Implications for Interpreting Gadolinium Signal Changes Within the Brain.

Invest Radiol 2019 Mar;54(3):169-176

Clinical Radiology, NHS Tayside, Ninewells Hospital and Medical School, Dundee, United Kingdom.

Objectives: The aim of this study was to examine the variation in signal intensity ratio (SIR) values in Eurospin gel phantoms and healthy volunteer (HV) brain images in response to different magnetic resonance imaging hardware and software settings.

Materials And Methods: Gel phantoms with T1 relaxation times similar to the dentate nucleus (DN), pons (P), globus palladus (GP), and thalamus (Th) were scanned using a T1-weighted 2-dimensional spin-echo sequence on 2 magnetic resonance imaging scanners (3 T and 1.5 T). Read More

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http://dx.doi.org/10.1097/RLI.0000000000000526DOI Listing

T2 Mapping in Prostate Cancer.

Invest Radiol 2019 Mar;54(3):146-152

From the Department of Radiology, University Hospital Jena, Jena, Germany.

Objectives: The aim of the study was to determine the quantitative T2 values in prostate tissue and evaluate them for detection and grading of prostate cancer.

Materials And Methods: After approval from the local ethics committee, morphological T2-weighted (T2w) images, apparent diffusion coefficient (ADC) maps from diffusion-weighted images, quantitative T2 maps, and calculated T2w images from 75 men (median age, 66.3 years; median PSA, 8. Read More

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http://dx.doi.org/10.1097/RLI.0000000000000520DOI Listing
March 2019
9 Reads

A Structured Survey on Adverse Events Occurring Within 24 Hours After Intravenous Exposure to Gadodiamide or Gadoterate Meglumine: A Controlled Prospective Comparison Study.

Invest Radiol 2018 Oct 30. Epub 2018 Oct 30.

From the Departmental Faculty of Medicine and Surgery, Università Campus Bio-Medico di Roma, Rome, Italy.

Objective: This study compares the incidence of new-onset symptoms within 24 hours after enhanced magnetic resonance imaging (eMRI) with intravenous administration of gadodiamide or gadoterate meglumine compared with a control group undergoing unenhanced MRI (uMRI).

Materials And Methods: A prospective cohort study (n = 1088 patients) was designed to assess the incidence of symptoms within 24 hours after administration of gadodiamide or gadoterate meglumine. The participants underwent a structured questionnaire by phone call before and 24 hours after the MRI scan to check for symptoms that were not present before the scan. Read More

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http://dx.doi.org/10.1097/RLI.0000000000000528DOI Listing
October 2018

Personalized 3D-Printed Transparent Liver Model Using the Hepatobiliary Phase MRI: Usefulness in the Lesion-by-Lesion Imaging-Pathologic Matching of Focal Liver Lesions-Preliminary Results.

Invest Radiol 2019 Mar;54(3):138-145

Department of Radiology, Seoul National University College of Medicine.

Purpose: The aim of this study was to investigate the usefulness of a personalized, 3-dimensional (3D)-printed, transparent liver model with focal liver lesions (FLLs) for lesion-by-lesion imaging-pathologic matching.

Materials And Methods: This preliminary, prospective study was approved by our institutional review board, and written informed consent was obtained. Twenty patients (male-to-female ratio, 13:7; mean age, 56 years) with multiple FLLs, including at least one presumed malignant, or an indeterminate lesion 10 mm or less on the preoperative gadoxetic acid-enhanced magnetic resonance imaging (MRI), were included. Read More

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http://dx.doi.org/10.1097/RLI.0000000000000521DOI Listing
March 2019
2 Reads

Native T1 Mapping as an In Vivo Biomarker for the Identification of Higher-Grade Renal Cell Carcinoma: Correlation With Histopathological Findings.

Invest Radiol 2019 Feb;54(2):118-128

Departments of Radiology.

Objectives: The aims of this study were to identify higher-grade clear cell renal cell carcinoma (cRCC) with native T1 mapping and to histologically correlate the results with the collagen volume fraction.

Materials And Methods: For this institutional review board-approved, single-center prospective study, 68 consecutive patients received abdominal magnetic resonance imaging scans at 1.5 T between January 2017 and July 2018, using a Modified Look-Locker Inversion Recovery (MOLLI) sequence. Read More

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http://dx.doi.org/10.1097/RLI.0000000000000515DOI Listing
February 2019
3 Reads

Impact of Treatment With Chelating Agents Depends on the Stability of Administered GBCAs: A Comparative Study in Rats.

Invest Radiol 2019 Feb;54(2):76-82

MR and CT Contrast Media Research, Bayer AG, Berlin, Germany.

Objective: This study investigated the potential effect of the chelating agent calcium trisodium pentetate (Ca-DTPA) on the urinary excretion of gadolinium and the subsequent elimination of gadolinium (Gd) in the brain after a single intravenous administration of either a linear (gadodiamide) or a macrocyclic (gadobutrol) Gd-based contrast agent in rats.

Materials And Methods: Rats received either a single injection of gadodiamide or gadobutrol (1.8 mmol/kg, each) or saline (n = 18 per group). Read More

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http://Insights.ovid.com/crossref?an=00004424-900000000-9896
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http://dx.doi.org/10.1097/RLI.0000000000000522DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310454PMC
February 2019
2 Reads

Impact of Machine Learning With Multiparametric Magnetic Resonance Imaging of the Breast for Early Prediction of Response to Neoadjuvant Chemotherapy and Survival Outcomes in Breast Cancer Patients.

Invest Radiol 2019 Feb;54(2):110-117

Department of Radiology, Breast Imaging Service, Memorial Sloan Kettering Cancer Center, New York, NY.

Purpose: The aim of this study was to assess the potential of machine learning with multiparametric magnetic resonance imaging (mpMRI) for the early prediction of pathological complete response (pCR) to neoadjuvant chemotherapy (NAC) and of survival outcomes in breast cancer patients.

Materials And Methods: This institutional review board-approved prospective study included 38 women (median age, 46.5 years; range, 25-70 years) with breast cancer who were scheduled for NAC and underwent mpMRI of the breast at 3 T with dynamic contrast-enhanced (DCE), diffusion-weighted imaging (DWI), and T2-weighted imaging before and after 2 cycles of NAC. Read More

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http://Insights.ovid.com/crossref?an=00004424-900000000-9896
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http://dx.doi.org/10.1097/RLI.0000000000000518DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310100PMC
February 2019
20 Reads

Improved Visualization of Juxtaprosthetic Tissue Using Metal Artifact Reduction Magnetic Resonance Imaging: Experimental and Clinical Optimization of Compressed Sensing SEMAC.

Invest Radiol 2019 Jan;54(1):23-31

From the Department of Radiology, Balgrist University Hospital.

Objectives: The purpose of this study was to identify an optimal imaging protocol for metal artifact reduced magnetic resonance imaging by application of different imaging and postprocessing parameters in compressed sensing slice-encoding for metal artifact correction (CS-SEMAC) and to test it in patients with total hip arthroplasty (THA).

Materials And Methods: In an experimental setup, a phantom consisting of a standard THA embedded in gadolinium-containing agarose was scanned at 1.5 T. Read More

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http://dx.doi.org/10.1097/RLI.0000000000000504DOI Listing
January 2019
6 Reads

Linearity, Bias, Intrascanner Repeatability, and Interscanner Reproducibility of Quantitative Multidynamic Multiecho Sequence for Rapid Simultaneous Relaxometry at 3 T: A Validation Study With a Standardized Phantom and Healthy Controls.

Invest Radiol 2019 Jan;54(1):39-47

Department of Radiology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

Objectives: The aim of this study was to evaluate the linearity, bias, intrascanner repeatability, and interscanner reproducibility of quantitative values derived from a multidynamic multiecho (MDME) sequence for rapid simultaneous relaxometry.

Materials And Methods: The NIST/ISMRM (National Institute of Standards and Technology/International Society for Magnetic Resonance in Medicine) phantom, containing spheres with standardized T1 and T2 relaxation times and proton density (PD), and 10 healthy volunteers, were scanned 10 times on different days and 2 times during the same session, using the MDME sequence, on three 3 T scanners from different vendors. For healthy volunteers, brain volumetry and myelin estimation were performed based on the measured T1, T2, and PD. Read More

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http://Insights.ovid.com/crossref?an=00004424-900000000-9897
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http://dx.doi.org/10.1097/RLI.0000000000000510DOI Listing
January 2019
1 Read

Synthetic 2-Dimensional Mammography Can Replace Digital Mammography as an Adjunct to Wide-Angle Digital Breast Tomosynthesis.

Invest Radiol 2019 Feb;54(2):83-88

From the Department of Biomedical Imaging and Image-Guided Therapy.

Objectives: The aim of this study was to evaluate the detection rate and diagnostic performance of 2-dimensional synthetic mammography (SM) as an adjunct to wide-angle digital breast tomosynthesis (WA-DBT) compared with digital mammography (DM) alone or to DM in combination with WA-DBT.

Materials And Methods: There were 205 women with 179 lesions included in this retrospective reader study. Patients underwent bilateral, 2-view (2v) DM and WA-DBT between March and June 2015. Read More

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http://Insights.ovid.com/crossref?an=00004424-900000000-9897
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http://dx.doi.org/10.1097/RLI.0000000000000513DOI Listing
February 2019
2 Reads

Clinical Feasibility of Gadoxetic Acid-Enhanced Isotropic High-Resolution 3-Dimensional Magnetic Resonance Cholangiography Using an Iterative Denoising Algorithm for Evaluation of the Biliary Anatomy of Living Liver Donors.

Invest Radiol 2019 Feb;54(2):103-109

Department of Surgery, Seoul National University Hospital, Seoul, Republic of Korea.

Objectives: The aim of this study was to evaluate the clinical feasibility of gadoxetic acid-enhanced isotropic high-resolution (IHR) 3-dimensional (3D) T1-weighted (T1W) magnetic resonance cholangiography (MRC) using an iterative denoising (ID) algorithm for evaluation of the biliary anatomy of living liver donors in comparison with conventional 3D multislice T2-weighted (T2W) MRC.

Materials And Methods: In this institutional review board-approved retrospective study, a total of 75 living liver donors who underwent conventional 3D multislice T2W-MRC and IHR-3D-T1W-MRC on a 3 T scanner and subsequent right hepatectomy for liver donation were included. Isotropic high-resolution T1W-MRCs were obtained in both axial and coronal planes using the 3D VIBE Dixon sequence and an ID algorithm implemented with wavelet thresholding of 3D complex-valued data of the noise level, g-factor, and k-space filtering. Read More

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http://Insights.ovid.com/crossref?an=00004424-201902000-0000
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http://dx.doi.org/10.1097/RLI.0000000000000512DOI Listing
February 2019
2 Reads

Detectability of Brain Metastases by Using Frequency-Selective Nonlinear Blending in Contrast-Enhanced Computed Tomography.

Invest Radiol 2019 Feb;54(2):98-102

From the Departments of Diagnostic and Interventional Radiology, and.

Purpose: The aim of this study to evaluate the role of frequency-selective nonlinear blending (FS-NLB) for the detectability of brain metastases with contrast-enhanced computed tomography (CECT) using magnetic resonance imaging (MRI) as standard of reference.

Materials And Methods: A retrospective patient data search at our institution yielded 91 patients who underwent both brain CECT and MRI for screening of brain metastases (n = 173) between 2014 and 2016 (mean time interval, 29 ± 37 [malignant: 15 ± 16/benign: 42 ± 47] days). A recently introduced FS-NLB postprocessing technique was applied to CECT images. Read More

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http://dx.doi.org/10.1097/RLI.0000000000000514DOI Listing
February 2019
1 Read

The Critical Need for Pediatric and Juvenile Animal Research Addressing Gadolinium Retention in the Developing Body.

Invest Radiol 2019 Feb;54(2):72-75

From the Department of Radiology and Radiological Science, Medical University of South Carolina, Charleston, SC.

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http://dx.doi.org/10.1097/RLI.0000000000000516DOI Listing
February 2019

Preoperative Evaluation of Pancreatic Fibrosis and Lipomatosis: Correlation of Magnetic Resonance Findings With Histology Using Magnetization Transfer Imaging and Multigradient Echo Magnetic Resonance Imaging.

Invest Radiol 2018 Dec;53(12):720-727

From the Institute of Diagnostic and Interventional Radiology.

Objectives: The purpose of this study was to evaluate the diagnostic performance of magnetization transfer (MT) imaging and multigradient echo magnetic resonance imaging (MRI) to quantify pancreatic fibrosis and lipomatosis in patients before pancreatoduodenectomy for postoperative risk stratification with histopathology as the reference standard.

Materials And Methods: Twenty-four patients (age, 68 ± 8 years, 16 males) prospectively underwent quantitative MT imaging using a 2-dimensional gradient echo sequence with and without MT prepulse and multigradient echo imaging on a 3 T MRI 1 day before pancreatoduodenectomy due to adenocarcinoma of the pancreatic head region (n = 20), neuroendocrine tumor (n = 3), or intraductal papillary mucinous neoplasm (n = 1). Magnetization transfer ratio (MTR) and proton density fat fraction (PDFF) were measured in pancreatic tail (PT) and at the resection margin (RM). Read More

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http://dx.doi.org/10.1097/RLI.0000000000000496DOI Listing
December 2018
2 Reads

Tomoelastography Paired With T2* Magnetic Resonance Imaging Detects Lupus Nephritis With Normal Renal Function.

Invest Radiol 2019 Feb;54(2):89-97

From the Departments of Radiology.

Objectives: The aim of this study was to test multiparametric magnetic resonance imaging including blood oxygen level-dependent (BOLD) imaging by T2* mapping, magnetic resonance elastography (MRE) by tomoelastography, and diffusion-weighted imaging (DWI) for detecting nephropathy in patients with lupus nephritis (LN).

Methods: Forty-one subjects (25 patients with LN and 16 age- and sex-matched healthy volunteers; LN: mean age, 47.3 ± 14. Read More

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http://dx.doi.org/10.1097/RLI.0000000000000511DOI Listing
February 2019
2 Reads

Evaluation of an AI-Based Detection Software for Acute Findings in Abdominal Computed Tomography Scans: Toward an Automated Work List Prioritization of Routine CT Examinations.

Invest Radiol 2019 Jan;54(1):55-59

From the Department of Radiology, University Hospital Basel, Basel, Switzerland.

Objective: The aim of this study was to test the diagnostic performance of a deep learning-based triage system for the detection of acute findings in abdominal computed tomography (CT) examinations.

Materials And Methods: Using a RIS/PACS (Radiology Information System/Picture Archiving and Communication System) search engine, we obtained 100 consecutive abdominal CTs with at least one of the following findings: free-gas, free-fluid, or fat-stranding and 100 control cases with absence of these findings. The CT data were analyzed using a convolutional neural network algorithm previously trained for detection of these findings on an independent sample. Read More

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http://dx.doi.org/10.1097/RLI.0000000000000509DOI Listing
January 2019
1 Read

Diffusion Tensor Imaging of Healthy Skeletal Muscles: A Comparison Between 7 T and 3 T.

Invest Radiol 2019 Jan;54(1):48-54

High-Field MR Center, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Austria.

Objective: The aim of this study was to assess and compare the overall performance, reliability, variability, as well as the accuracy of diffusion tensor imaging (DTI) and fiber tracking metrics, for the muscles of the calf at 3 T and 7 T.

Materials And Methods: Ten volunteers (5 males; mean age, 29.1 ± 4. Read More

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http://dx.doi.org/10.1097/RLI.0000000000000508DOI Listing
January 2019
3 Reads

Ultrashort Time-to-Echo Magnetic Resonance Imaging at 3 T for the Detection of Spondylolysis in Cadaveric Spines: Comparison With CT.

Invest Radiol 2019 Jan;54(1):32-38

Department of Radiology, VA San Diego Healthcare System, San Diego, CA.

Objectives: The objective of this study was to compare the diagnostic performance and confidence of conventional, optimized, and ultrashort time to echo (UTE) magnetic resonance (MR) protocols for detection of simulated lumbar spondylolysis in human cadavers. In addition, we sought to demonstrate the feasibility of the UTE technique in subjects with and without spondylolysis.

Materials And Methods: Four human lumbar spine specimens with 46 individual pars interarticularis were randomly left intact (n = 26) or received experimental osteotomy (n = 20) using a microsurgical saw to simulate spondylolysis. Read More

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http://dx.doi.org/10.1097/RLI.0000000000000506DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269191PMC
January 2019
15 Reads

Accurate Therapeutic Response Assessment of Pancreatic Ductal Adenocarcinoma Using Quantitative Dynamic Contrast-Enhanced Magnetic Resonance Imaging With a Point-of-Care Perfusion Phantom: A Pilot Study.

Invest Radiol 2019 Jan;54(1):16-22

Departments of Medicine, and.

Objectives: The aim of this study was to test the feasibility of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) with concurrent perfusion phantom for monitoring therapeutic response in patients with pancreatic ductal adenocarcinoma (PDAC).

Materials And Methods: A prospective pilot study was conducted with 8 patients (7 men and 1 woman) aged 46 to 78 years (mean age, 66 years). Participants had either locally advanced (n = 7) or metastatic (n = 1) PDAC, and had 2 DCE-MRI examinations: one before and one 8 ± 1 weeks after starting first-line chemotherapy. Read More

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http://dx.doi.org/10.1097/RLI.0000000000000505DOI Listing
January 2019
10 Reads

Dechelation (Transmetalation): Consequences and Safety Concerns With the Linear Gadolinium-Based Contrast Agents, In View of Recent Health Care Rulings by the EMA (Europe), FDA (United States), and PMDA (Japan).

Authors:
Val M Runge

Invest Radiol 2018 Oct;53(10):571-578

From the Department of Diagnostic, Interventional and Pediatric Radiology, Inselspital, University Hospital, University of Bern, Bern, Switzerland.

The issue of dechelation (transmetallation) in vivo after administration of the linear gadolinium-based contrast agents, and potential safety concerns, is considered on the basis of an extensive, focused literature review. Early indications of potential problems included the high level of excess ligand used in the formulation of 2 agents (indeed the 2 least stable thermodynamically) and interference with laboratory tests when blood was drawn from patients relatively soon after administration of these same agents. The advent of nephrogenic systemic fibrosis in the late 2000s raised additional major concerns. Read More

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http://dx.doi.org/10.1097/RLI.0000000000000507DOI Listing
October 2018
6 Reads

Interscanner and Intrascanner Comparison of Virtual Unenhanced Attenuation Values Derived From Twin Beam Dual-Energy and Dual-Source, Dual-Energy Computed Tomography.

Invest Radiol 2019 Jan;54(1):1-6

Radiology Institute University of Turin, Turin, Italy.

Objective: The aim of the current study was to evaluate the reliability and comparability of virtual unenhanced (VUE) attenuation values derived from scans of a single-source, dual-energy computed tomography using a split-filter (tbDECT) to a dual-source dual-energy CT (dsDECT).

Materials And Methods: In this retrospective study, comparisons for tbDECT and dsDECT were made within and between different dual-energy platforms. For the interscanner comparison, 126 patients were scanned with both scanners within a time interval of 224 ± 180 days; for the intrascanner comparison, another 90 patients were scanned twice with the same scanner within a time interval of 136 ± 140 days. Read More

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http://dx.doi.org/10.1097/RLI.0000000000000501DOI Listing
January 2019
1 Read

Three-Dimensional High-Resolution Black-Blood Magnetic Resonance Imaging for Detection of Arteritic Anterior Ischemic Optic Neuropathy in Patients With Giant Cell Arteritis.

Invest Radiol 2018 Nov;53(11):698-704

Radiologisches Zentrum Rosenheim, Rosenheim, Germany.

Objectives: Arteritic anterior ischemic optic neuropathy (A-AION) caused by inflammatory occlusion of the posterior ciliary arteries is the most common reason for irreversible vision loss in patients with giant cell arteritis. Atypical clinical presentation and negative funduscopy can delay systemic high-dose corticosteroid therapy to prevent impending permanent blindness and involvement of the contralateral eye.The purpose of this study was to assess the diagnostic accuracy of 3-dimensional (3D) high-resolution T1-weighted black-blood magnetic resonance imaging (T1-BB-MRI) for the detection of posterior ciliary artery involvement in patients with giant cell arteritis and funduscopic A-AION. Read More

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http://dx.doi.org/10.1097/RLI.0000000000000500DOI Listing
November 2018
14 Reads
4.440 Impact Factor

Fully Automated 10-Minute 3D CAIPIRINHA SPACE TSE MRI of the Knee in Adults: A Multicenter, Multireader, Multifield-Strength Validation Study.

Invest Radiol 2018 Nov;53(11):689-697

Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD.

Objectives: The aim of this study was to test the hypothesis that magnetic resonance imaging (MRI) of the knee with 10-minute 3-dimensional (3D) controlled aliasing in parallel imaging results in higher acceleration (CAIPIRINHA) sampling perfection with application optimized contrast using different flip angle evolutions (SPACE) turbo spin echo (TSE) protocols can replace 20-minute 2-dimensional (2D) TSE standard-of-reference protocols for the diagnosis of internal derangement.

Materials And Methods: After internal review board approval and prospective informed consent, 100 symptomatic subjects underwent MRI of the knee at 3 T and 50 symptomatic subjects at 1.5 T, consisting of 10-minute 3D CAIPIRINHA SPACE TSE and 20-minute standard-of-reference 2D TSE protocols. Read More

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http://Insights.ovid.com/crossref?an=00004424-900000000-9898
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http://dx.doi.org/10.1097/RLI.0000000000000493DOI Listing
November 2018
3 Reads