257 results match your criteria Inverted Papilloma of the Urinary Bladder


Inverted papilloma of the urinary bladder shows fluorescence on photodynamic diagnosis using 5-aminolevulinic acid.

Photodiagnosis Photodyn Ther 2020 Jun 18;30:101766. Epub 2020 Apr 18.

Department of Urology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

Photodynamic diagnosis (PDD) of non-muscle invasive bladder cancer using 5-aminolevulinic acid (5-ALA) has recently attracted attention as a diagnostic method for observing cancer lesions based on fluorescence emission using a fluorescent endoscope. However, there are few reports of false positives associated with benign bladder neoplasms. Here, we provide report of two cases of inverted papillomas of the bladder that were fluorescent on PDD using 5-ALA. Read More

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http://dx.doi.org/10.1016/j.pdpdt.2020.101766DOI Listing

Glandular-type inverted papilloma of urinary bladder - Report of a unique case with immunohistochemistry.

Indian J Pathol Microbiol 2020 Jan-Mar;63(1):96-97

Department of Urology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Inverted papilloma of urothelium is a rare benign tumour accounting for 1-2% of all the urothelial lesions. Morphologically, these are of two main subtypes - trabecular and glandular, of which the former subtype is most frequently encountered compared to the latter. The glandular subtype closely mimics cystitis glandularis and urothelial carcinoma with inverted growth pattern. Read More

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http://dx.doi.org/10.4103/IJPM.IJPM_456_18DOI Listing
February 2020

[Inverted Variant of Urothelial Carcinoma of the Urinary Bladder : A Case Report].

Hinyokika Kiyo 2019 Nov;65(11):463-467

The Department of Molecular Pathology, Shinshu University School of Medicine.

A 69-year-old male complained of gross hematuria. Cystoscopy revealed a papillary pedunculated tumor. The tumor was approximately 4 cm in length, and mimicked an inverted papilloma with a small stalk and smooth surface, located on the bladder trigone. Read More

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http://dx.doi.org/10.14989/ActaUrolJap_65_11_463DOI Listing
November 2019

Invasive high-grade urothelial carcinoma of the bladder, renal pelvis, ureter, and prostatic urethra arising in a background of urothelial carcinoma with an inverted growth pattern: a contemporary clinicopathological analysis of 91 cases.

Hum Pathol 2019 10 24;92:18-24. Epub 2019 Jul 24.

Department of Pathology, Emory University School of Medicine, Atlanta, GA 30322; Department of Urology, Emory University School of Medicine, Atlanta, GA 30322; Department of Pathology, Veterans Affairs Medical Center, Decatur, GA 30033; Winship Cancer Institute of Emory University, Atlanta, GA 30322. Electronic address:

Urothelial carcinoma with an inverted/endophytic growth pattern can occasionally mimic inverted urothelial papilloma and pose diagnostic challenges when assessing the presence or absence of invasion. Making these distinctions is critical for guiding appropriate treatment and improving patient outcomes. Here we conducted one of the largest studies to date of invasive high-grade urothelial carcinoma arising in a background of urothelial carcinoma with an inverted growth pattern. Read More

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http://dx.doi.org/10.1016/j.humpath.2019.07.005DOI Listing
October 2019

Distinct mutational landscape of inverted urothelial papilloma.

J Pathol 2019 09 2;249(1):3-5. Epub 2019 Jul 2.

Department of Pathology, Indiana University School of Medicine, Indianapolis, IN, USA.

A recent study has identified gene mutations involving the MAPK/ERK pathway, particularly the HRAS gene, in all inverted urothelial papillomas (IUPs), in the absence of pathway mutations in TERT promoter, FGFR3, and TP53/RB1genes. Neither recurrence nor progression was observed in IUPs. These data support several longstanding hypotheses: (1) IUPs are benign and do not recur or progress; (2) they harbor mutations that are different from those of urothelial carcinoma; and (3) they arise through different molecular mechanisms than low- or high-grade urothelial carcinoma. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/path.5307
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http://dx.doi.org/10.1002/path.5307DOI Listing
September 2019
30 Reads

Genomic landscape of inverted urothelial papilloma and urothelial papilloma of the bladder.

J Pathol 2019 07 22;248(3):260-265. Epub 2019 Apr 22.

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Inverted urothelial papilloma (IUP) and urothelial papilloma (UP) are rare urothelial neoplasms that typically follow a benign clinical course. Oncogenic mutations in FGFR3, HRAS, and the TERT promoter have been reported in these entities but no comprehensive molecular analysis has been performed. We sought to characterize the genomic landscape of IUP and UP using whole-exome and targeted next-generation sequencing. Read More

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http://doi.wiley.com/10.1002/path.5261
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http://dx.doi.org/10.1002/path.5261DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6579631PMC
July 2019
26 Reads

Diagnostic Value of Glucose Transporter 1 (GLUT-1) Expression in Nested Variant of Urothelial Carcinoma.

Turk Patoloji Derg 2019 ;35(1):22-27

Department of Pathology, 1Sultanbeyli State Hospital, ISTANBUL, TURKEY.

Objective: Nested variant is bland-looking but aggressive subtype of urothelial carcinoma (UC). Cases having significant muscle invasion do not cause problems but small and superficial biopsies may be challenging due to morphological similarities between nested variant urothelial carcinoma and benign urothelial lesions.

Material And Method: We studied Glucose transporter 1 (GLUT-1), which is an integral membrane protein providing glucose pass through plasma membrane down its concentration gradient, to see if it is useful for the differential diagnosis. Read More

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http://www.turkjpath.org/doi.php?doi=10.5146/tjpath.2018.014
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http://dx.doi.org/10.5146/tjpath.2018.01435DOI Listing
August 2019
4 Reads

Benign inverted papilloma at bladder neck causing acute urinary retention.

J Surg Case Rep 2018 Jun 15;2018(6):rjy125. Epub 2018 Jun 15.

Department of Urological Sciences, University of British Columbia, Vancouver, BC, Canada.

Inverted papilloma of the urinary tract is a rare benign lesion. A 59-year-old male who presented with the chief complaint of gross hematuria and acute urinary retention is described. Cystoscopy revealed a solitary, papillary tumor at the bladder neck. Read More

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https://academic.oup.com/jscr/article/doi/10.1093/jscr/rjy12
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http://dx.doi.org/10.1093/jscr/rjy125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6007691PMC
June 2018
30 Reads

Management of Inverted Papilloma During Holmium Laser Enucleation of the Prostate.

Urology 2018 Jun 12;116:e5-e6. Epub 2018 Mar 12.

Department of Urology, University of California, San Francisco, San Francisco, CA.

Inverted papilloma of the prostatic urethra is an especially rare finding. A 75-year-old man with urinary retention wished to proceed with a holmium laser enucleation of the prostate (HoLEP) and was found to have a mass arising from his prostate vs bladder on preoperative imaging. Cystourethroscopy revealed the mass arising from the median lobe of the prostate. Read More

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http://dx.doi.org/10.1016/j.urology.2018.01.009DOI Listing
June 2018
11 Reads

Biological significance of TERT promoter mutation in papillary urothelial neoplasm of low malignant potential.

Histopathology 2018 Apr 4;72(5):795-803. Epub 2018 Jan 4.

Department of Pathology, National Taiwan University Hospital, Taipei, Taiwan.

Aims: Mutations in FGFR3 and the promoter region of the telomerase reverse transcriptase (TERT) gene have been found frequently in urothelial carcinoma of the urinary bladder. However, related data for papillary urothelial neoplasm of low malignant potential (PUNLMP) are limited. In this study, we investigated the mutation status of the TERT promoter, FGFR3 and HRAS in low-grade papillary urothelial neoplasms and evaluated their prognostic significance. Read More

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http://dx.doi.org/10.1111/his.13441DOI Listing
April 2018
24 Reads

Conservative treatment of upper urinary tract carcinoma: Long-term results.

Can Urol Assoc J 2017 Jul 11;11(7):E291-E296. Epub 2017 Jul 11.

Department of Urology, Ramón y Cajal University Hospital, Madrid, Spain.

Introduction: We sought to assess the long-term results of conservative treatment for upper urinary tract carcinoma (UUTC) with regard to tumour recurrence and preservation of renal unit.

Methods: From October 1987 to January 2014, 65 patients (median age 68 years) were diagnosed with UUTC and underwent endoscopic and open surgical techniques. Thirteen patients had bilateral disease and one had a single kidney. Read More

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http://www.cuaj.ca/index.php/journal/article/view/4173
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http://dx.doi.org/10.5489/cuaj.4173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5519388PMC
July 2017
40 Reads

[Inverted papilloma of the bladder: a rare benign tumor: a case report].

Pan Afr Med J 2017;26:204. Epub 2017 Apr 13.

Service d'Urologie, Centre hospitalier de Soissons, Soissons, France.

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http://www.panafrican-med-journal.com/content/article/26/204
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http://dx.doi.org/10.11604/pamj.2017.26.204.12266DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5491722PMC
February 2018
19 Reads

Inverted Papilloma of the Bladder Coexisting with Urothelial Carcinoma. A Case Report.

Anal Quant Cytopathol Histpathol 2016 Feb;38(1):52-6

Background: Inverted papilloma (IP) is an unusual benign neoplasm, most commonly found in the bladder. Cases of malignant transformation have been reported in the past, although most of them are now considered to be urothelial carcinomas with an inverted growth pattern.

Case: A 54-year-old man was diagnosed with urothelial carcinoma in situ (UCIS), high-grade papillary urothelial carcinoma (HGPUC), and IP by transurethral resection specimen of the bladder. Read More

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February 2016
53 Reads

The pathology of urinary bladder lesions with an inverted growth pattern.

Chin J Cancer Res 2016 Feb;28(1):107-21

1 Department of Pathology, Chinese PLA General Hospital, Beijing 100853, China ; 2 Department of Pathology, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310058, China.

Inverted lesions in the urinary bladder have been the source of some difficulty in urological pathology. The two common ones are von Brunn's nests and cystitis cystic/cystitis glandularis, which are considered normal variants of urothelium. Apart from them, a number of other rare urothelial lesions with inverted growth pattern occur in the urinary bladder. Read More

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http://dx.doi.org/10.3978/j.issn.1000-9604.2016.02.01DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4779755PMC
February 2016
95 Reads

Recurrent TERT promoter mutations in urothelial carcinoma and potential clinical applications.

Ann Diagn Pathol 2016 Apr 17;21:7-11. Epub 2015 Dec 17.

Department of Pathology, Westchester Medical Center/New York Medical College, Valhalla, NY; Department of Pathology, Mount Sinai Medical Center, New York, NY. Electronic address:

Increased telomerase activity is associated with almost all types of advanced human cancers with unknown molecular mechanism(s). Two recurrent point mutations in the promoter region of telomerase reverse transcriptase (TERT)--the key subunit of telomerase--have recently been identified in melanoma as well as a small sample of bladder cancer cell lines. However, the incidence and clinical-pathological significance of these mutations in urothelial carcinoma have not been well established yet. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10929134150015
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http://dx.doi.org/10.1016/j.anndiagpath.2015.12.002DOI Listing
April 2016
47 Reads

Telomerase reverse transcriptase (TERT) promoter mutation analysis of benign, malignant and reactive urothelial lesions reveals a subpopulation of inverted papilloma with immortalizing genetic change.

Histopathology 2016 Jul 11;69(1):107-13. Epub 2016 Feb 11.

Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.

Aims: To understand more clearly the genetic ontogeny of inverted papilloma of urinary bladder, we analysed telomerase reverse transcriptase (TERT) promoter mutation status in a group of 26 inverted papillomas in comparison with the mutation status of urothelial carcinoma with inverted growth (26 cases), conventional urothelial carcinoma (36 Ta non-invasive urothelial carcinoma, 35 T2 invasive urothelial carcinoma) and cystitis glandularis (25 cases).

Methods And Results: TERT promoter mutations in inverted papilloma, urothelial carcinoma with inverted growth, urothelial carcinoma and cystitis glandularis were found in 15% (four of 26), 58% (15 of 26), 63% (45 of 71) and 0% (none of 25), respectively. C228T mutations were the predominant mutations (97%) found in bladder tumours, while C250T aberrations occurred in approximately 3% of bladder tumours. Read More

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http://dx.doi.org/10.1111/his.12920DOI Listing
July 2016
75 Reads

A clinical and molecular review of inverted papilloma of the urinary tract: how to handle?

APMIS 2015 Nov 11;123(11):920-9. Epub 2015 Sep 11.

Department of Urology, Bispebjerg and Frederiksberg Hospitals, University of Copenhagen, Copenhagen, Denmark.

Inverted papilloma (IP) of the urinary tract is classified by the World Health Organisation as a non-invasive urothelial tumour with normal to minimal cytological atypia of the neoplastic cells. During the 1980s, it came under suspicion of having a premalignant or malignant potential and of being concurrent with urothelial cell carcinoma (UCC). This quandary has been proven difficult to solve, due to the fact that IP is very rare and literature mostly consists of case reports with varying levels of information, making strong meta-analyses problematic. Read More

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http://doi.wiley.com/10.1111/apm.12456
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http://dx.doi.org/10.1111/apm.12456DOI Listing
November 2015
68 Reads

Inverted urothelial carcinoma: a series of 12 cases with a wide morphologic spectrum overlapping with the large nested variant.

Hum Pathol 2015 Oct 26;46(10):1506-13. Epub 2015 Jun 26.

Department of Pathology, Hôpital du Sacré-Coeur de Montréal, Montreal, Quebec H4J1C5, Canada.

The current series presents 12 cases of invasive urothelial carcinoma (UC) with inverted growth pattern that fulfill the architectural criteria of the recently described "large nested" variant of UC, but which display a wider spectrum of morphologic and cytologic changes. All cases had an associated component of usual invasive UC, and 10 had an associated surface papillary component. Although many areas within the tumors were indistinguishable from a noninvasive endophytic growth pattern, at least some had an irregular ragged contour, and all showed haphazard arrangement with variable amount of intervening stroma at least focally. Read More

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http://dx.doi.org/10.1016/j.humpath.2015.06.010DOI Listing
October 2015
36 Reads

MRI Findings of Inverted Urothelial Papilloma of the Bladder.

AJR Am J Roentgenol 2015 Aug;205(2):311-6

1 Department of Radiology, Nagoya City University Graduate School of Medical Sciences and Medical School, 1 Kawasumi Mizuho-cho, Mizuho-ku, Nagoya, Aichi 467-8601, Japan.

Objective: The objective of this study was to characterize MRI findings of inverted urothelial papilloma of the bladder.

Materials And Methods: Data pertaining to 16 patients with 18 pathologically proven inverted urothelial papillomas of the bladder who had undergone MRI were retrospectively collected from seven institutions. The shape and surface characteristics of the tumors were evaluated using T2-weighted MR images. Read More

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http://dx.doi.org/10.2214/AJR.14.13879DOI Listing
August 2015
57 Reads

Long-term outcome of primary Papillary Urothelial Neoplasm of Low Malignant Potential (PUNLMP) including PUNLMP with inverted growth.

Diagn Pathol 2015 Mar 13;10. Epub 2015 Mar 13.

Department of Pathology and Laboratory Medicine, Calgary Laboratory Service and University of Calgary, Rockyview General Hospital, 7007 14 Street, Calgary, AB, Canada.

Background: Few larger studies have evaluated the long-term outcome after a diagnosis of papillary urothelial neoplasm of low malignant potential (PUNLMP), demonstrating a broad range of recurrence and progression rates. Additionally, no study has addressed the outcome of PUNLMP exhibiting inverted growth. We evaluated the long term clinical outcome of primary papillary urothelial neoplasm of low malignant potential (PUNLMP), including PUNLMP with inverted growth in a large single center study. Read More

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http://dx.doi.org/10.1186/s13000-015-0234-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4415259PMC
March 2015
51 Reads
4 Citations
2.411 Impact Factor

Nested and microcystic variants of urothelial carcinoma displaying immunohistochemical features of basal-like urothelial cells: an immunohistochemical and histopathogenetic study.

Pathol Int 2014 Aug;64(8):375-81

Pathology and Laboratory Medicine, The Ottawa Hospital and University of Ottawa, Ottawa, Ontario, Canada.

Nested/microcystic (NV/MV) urothelial carcinoma (UC) variants are associated with mild cytologic atypia and commonly present at high-stage disease. The histopathogenesis is investigated using urothelial basal cell markers. Archival 14 NV/MV and three inverted papilloma (IP) were immunostained for CD44, cytokeratin 5 (CK5), CK34bE12 and p63. Read More

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http://dx.doi.org/10.1111/pin.12187DOI Listing
August 2014
25 Reads

HRAS mutations are frequent in inverted urothelial neoplasms.

Hum Pathol 2014 Sep 18;45(9):1957-65. Epub 2014 Jun 18.

Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA. Electronic address:

Inverted urothelial papilloma (IUP) is an uncommon neoplasm of the urinary bladder with distinct morphologic features. Studies regarding the role of human papillomavirus (HPV) in the etiology of IUP have provided conflicting evidence of HPV infection. In addition, little is known regarding the molecular alterations present in IUP or other urothelial neoplasms, which might demonstrate inverted growth pattern like low-grade or high-grade urothelial carcinoma (UCA). Read More

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http://dx.doi.org/10.1016/j.humpath.2014.06.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4241848PMC
September 2014
56 Reads

Long-term clinical outcome of inverted urothelial papilloma including cases with focal papillary pattern: is continuous surveillance necessary?

Urology 2013 Oct;82(4):857-60

Department of Pathology and Laboratory Medicine, University of Calgary and Calgary Laboratory Services, Calgary, Alberta, Canada.

Objective: To investigate the necessity for continuous cystoscopic surveillance of inverted papilloma (IP), including tumors exhibiting mixed morphology (IP with focal papillary architecture).

Methods: We retrieved all cases of de novo ("primary") IP, diagnosed in our institution during 10 years (from January 2000 to December 2009), from the information database. Patients with a history of urothelial carcinoma or concurrent urothelial carcinoma were excluded. Read More

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http://dx.doi.org/10.1016/j.urology.2013.06.040DOI Listing
October 2013
35 Reads
3 Citations
2.190 Impact Factor

Human papillomavirus is not an etiologic agent of urothelial inverted papillomas.

Am J Surg Pathol 2013 Aug;37(8):1223-8

Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

Inverted papilloma of the urinary bladder is rare, accounting for <1% of all bladder neoplasms. Although there is general consensus that inverted papilloma is benign in nature, little is known about its pathogenesis. Some have suggested that human papillomavirus (HPV) plays an etiologic role in the development of this neoplasm. Read More

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http://dx.doi.org/10.1097/PAS.0b013e3182863fc1DOI Listing
August 2013
21 Reads

[A case of inverted urothelial carcinoma of bladder].

Hinyokika Kiyo 2013 Apr;59(4):243-6

The Department of Urology, Sagamidai Hospital, Japan.

We present a case of inverted urothelial carcinoma of the bladder. A 60-year-old male was referred to our hospital for bilateral ureteral stones. When transurethral ureterolithotripsy was performed to treat these stones, a tumor at the trigone of bladder was incidentally diagnosed. Read More

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April 2013
25 Reads

Inverted variant of urothelial carcinoma of the urinary bladder: a report of three cases and a proposal for a new clinicopathologic entity.

Authors:
Tadashi Terada

Int J Clin Exp Pathol 2013 15;6(4):766-70. Epub 2013 Mar 15.

Department of Pathology, Shizuoka City Shimizu Hospital, Shizuoka, Japan.

Inverted urothelial carcinoma (UC) without papillary areas is very rare; only 31 cases of three papers have been reported. The author herein reports three additional cases, and proposes the term "inverted variant" (IV) of UC. The materials were 3 cases of IV of UC, 5 cases of inverted papilloma (IP), and two cases of nested variant (NV) of UC. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3606868PMC
October 2013
23 Reads

[A case of inverted papilloma of the renal pelvis, associated with metachronous urothelial carcinoma of the urinary bladder].

Hinyokika Kiyo 2013 Feb;59(2):121-4

The Department of Urology, Tsudanuma Central General Hospital, Japan.

The patient visited our hospital because of macrohematuria. Cystoscopical examination did not reveal any bladder tumors but a tumor shadow in the right renal pelvis was revealed by computed tomographic scan. Urothelial carcinoma was suspected and right nephroureterectomy was performed. Read More

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February 2013
36 Reads

Telomere shortening distinguishes inverted urothelial neoplasms.

Histopathology 2013 Mar 5;62(4):595-601. Epub 2013 Feb 5.

Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

Aims: To investigate relative telomere length in inverted urothelial neoplasms, including inverted papilloma and urothelial carcinoma with an inverted growth pattern. Telomere shortening has been implicated as an early event in the development of epithelial malignancies in a number of organ systems.

Methods And Results: Formalin-fixed, paraffin-embedded tissue sections from 77 cases were studied, including 26 cases of inverted papilloma, 26 urothelial carcinomas with inverted growth, and 25 cases of cystitis glandularis. Read More

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http://dx.doi.org/10.1111/his.12030DOI Listing
March 2013
33 Reads

A synchronous occurrence of urothelial carcinoma with abundant myxoid stroma and inverted papilloma of the urinary bladder.

Rare Tumors 2012 Jun 14;4(3):e45. Epub 2012 Sep 14.

Department of Pathology, Istanbul Education and Research Hospital, Ministry of Health, Istanbul;

Abundant myxoid stroma rarely occurs in urothelial carcinomas, and may cause diagnostic challenges when cells with eosinophilic cytoplasm forming nests and cords in a myxoid background are seen, particularly in the absence of typical carcinomatous appearance. Microscopic examination of transurethral resection specimen of a 71-year-old male patient revealed non-cohesive oval or elongated tumor cells with eosinophilic cytoplasm arranged in cord-like filigree pattern in an abundant myxoid stroma. Immunohistochemically the tumor was positive for cytokeratin 7, cytokeratin 20, and 34BE12. Read More

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http://dx.doi.org/10.4081/rt.2012.e45DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3475952PMC
June 2012
62 Reads

[Clinical studies of inverted papilloma of the bladder].

Hinyokika Kiyo 2012 Sep;58(9):471-4

The Department of Urology, Chigasaki City Hospital, Japan.

Inverted papilloma of the bladder is an uncommon urothelial neoplasm. Although it is traditionally regarded as a benign tumor, there are conflicting data on multiplicity, reoccurrence rate, and association with urothelial carcinoma. From 2005 to 2011, 14 cases of inverted papilloma of the bladder were diagnosed at our hospital. Read More

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September 2012
39 Reads

Morphological keys in the differential diagnosis of bladder inverted papilloma. Study of two types, trabecular and glandular.

Arch Esp Urol 2012 Sep;65(7):709-13

Pathology Department, Consorcio, Hospital General Universitario, Hospital Casa Salud, Valencia, Spain.

Objective: Inverted papilloma of the urinary bladder is an uncommon urothelial neoplasm that may be specially difficult to distinguish from urothelial carcinoma.

Methods: Two patients with obstructive symptoms and hematuria have been studied. In the transurethral resection, accidentally, one showed a papillary lesion in the context of nodular hyperplasia of the prostate, where as the other showed a polypoid tumor of the urinary bladder

Results: Histologically, in both cases, a bladder inverted papilloma was demonstrated, originating from the surface transitional epithelium. Read More

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September 2012
24 Reads

Inverted papilloma of the bladder: a review and an analysis of the recent literature of 365 patients.

Urol Oncol 2013 Nov 19;31(8):1584-90. Epub 2012 Apr 19.

Urology Department, University of Milan, IRCCS Policlinico San Donato, San Donato Milanese, Italy. Electronic address:

Objectives: Until the 1970s, inverted urothelial papilloma (IUP) of the bladder was generally regarded as a benign neoplasm. However, in the 1980s, several reported cases suggested the malignant potential of these papillomas, including cases with features indicative of malignancy, recurrent cases, and cases of IUP synchronous or metachronous with transitional cell carcinoma. The aim of this systematic review and analysis of the literature since 1990 to date is to contribute to unresolved issues regarding the biological behavior and prognosis of these neoplasms to establish some key points in the clinical and surgical management of IUP. Read More

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http://dx.doi.org/10.1016/j.urolonc.2012.03.009DOI Listing
November 2013
36 Reads

Nested variant of urothelial carcinoma of the urinary bladder.

Authors:
Tadashi Terada

Rare Tumors 2011 Oct 27;3(4):e42. Epub 2011 Dec 27.

Department of Pathology, Shizuoka City Shimizu Hospital, Shizuoka, Japan.

The nested variant of urothelial carcinoma (NVUC) is characterized by the presence of benign-appearing urothelial carcinoma cells in the lamina propria, sparing the surface urothelial involvement. NVUC shows aggressive clinical course despite of benign-looking histology. Herein reported are two cases of NVUC. Read More

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http://journals.sagepub.com/doi/10.4081/rt.2011.e42
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http://dx.doi.org/10.4081/rt.2011.e42DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3282447PMC
October 2011
38 Reads

Expression of claudins and their prognostic significance in noninvasive urothelial neoplasms of the human urinary bladder.

J Histochem Cytochem 2011 Oct 10;59(10):932-41. Epub 2011 Aug 10.

2nd Department of Pathology, Semmelweis University, Budapest, Hungary.

The members of the claudin family are major integral transmembrane protein constituents of tight junctions. Normal and neoplastic tissues can be characterized by unique qualitative and quantitative distribution of claudin subtypes, which may be related to clinicopathological features. Differential diagnosis and prognosis of nonmuscle invasive tumor entities of urinary bladder epithelium are often challenging. Read More

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http://dx.doi.org/10.1369/0022155411418829DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3201131PMC
October 2011
28 Reads

Inverted papilloma of the cervix and vagina: report of 2 cases of a rare lesion associated with human papillomavirus 42.

Hum Pathol 2012 Mar 2;43(3):435-9. Epub 2011 Aug 2.

Department of Pathology, Belfast Health and Social Care Trust, Belfast, Northern Ireland BT 12 6BA.

We report 2 cases of a lesion that we term inverted papilloma of the lower female genital tract, occurring in the cervix and upper vagina of 60- and 50-year-old women, respectively. Microscopically, the features were similar to those of inverted transitional papilloma of the urinary bladder with interconnecting islands, trabeculae, and solid sheets of bland transitional epithelium with an inverted growth pattern. There were small foci of squamous and glandular differentiation in the cervical case. Read More

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http://linkinghub.elsevier.com/retrieve/pii/S004681771100201
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http://dx.doi.org/10.1016/j.humpath.2011.03.011DOI Listing
March 2012
37 Reads

[Urothelial hyperplastic lesion with endophytic growth pattern: a clinicopathologic study].

Zhonghua Bing Li Xue Za Zhi 2011 May;40(5):319-23

Department of Pathology, Huadong Hospital, Fudan University, Shanghai 200040, China.

Objective: To study the clinicopathologic features of urothelial hyperplastic lesion with an endophytic growth pattern and the role of immunohistochemistry and multitargeted fluorescence in situ hybridization (FISH) in the differential diagnosis.

Methods: Forty-one cases of urothelial lesions exhibiting endophytic growth patterns were reviewed and reclassified as inverted papilloma, urothelial carcinoma with an endophytic growth pattern, and florid von Brunn nest. The gains of chromosomes 3, 7, and 17 and loss of 9p21 was detected by FISH, and performed immunohistochemical staining for CK20, p53, and Ki-67. Read More

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May 2011
22 Reads

Inverted papilloma of the urinary tract.

BJU Int 2011 Apr;107 Suppl 3:24-6

Tissugen Pty Ltd, Perth, Western Australia.

Objectives: • To compare the clinical and pathological details of inverted papilloma (IP) of the urinary tract diagnosed in Western Australia with those published. • To determine whether urinary tract IP requires post-treatment cystoscopic follow-up.

Patients And Methods: • Clinical and pathological details were summarized for 41 cases of IP of the urinary tract diagnosed in Western Australia between 1998 and 2010. Read More

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http://dx.doi.org/10.1111/j.1464-410X.2011.10046.xDOI Listing
April 2011
49 Reads

Virtual cystoscopy: the evaluation of bladder lesions with computed tomographic virtual cystoscopy.

Can Urol Assoc J 2011 Feb;5(1):34-7

Ministry of Health, Ankara Dışkapı Yıldırım Beyazit Education and Research Hospital, Department of Urology, Ankara, Turkey.

Purpose: Our objective was to assess the accuracy of computed tomographic virtual cystoscopy (CTVC) in the detection of urinary bladder lesions.

Methods: Twenty-five patients were examined using CTVC. Bladder scanned using multislice CT at a slice thickness of 1 mm. Read More

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http://dx.doi.org/10.5489/cuaj.10002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3036754PMC
February 2011
47 Reads

Etiological role of human papillomavirus infection for inverted papilloma of the bladder.

J Med Virol 2011 Feb;83(2):277-85

Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan.

The status of human papillomavirus (HPV) infection in urothelial inverted papilloma was examined in the present study. Formalin-fixed and paraffin-embedded tissues from eight cases of inverted papilloma of the bladder were studied. The presence of HPV-DNA was examined by modified GP5/6+PCR using archival tissue sections by microdissection. Read More

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http://dx.doi.org/10.1002/jmv.21966DOI Listing
February 2011
24 Reads

Inverted papilloma of the urinary bladder: Rigorous surveillance needed? An Indian experience.

Indian J Cancer 2010 Oct-Dec;47(4):418-23

Department of Urology, IPGMER & SSKM, Kolkata, India.

Aims: Inverted papilloma (IP) is an uncommon benign neoplasm of the urinary tract. Its multiplicity, recurrence, and association with transitional cell carcinoma (TCC) leads to conflicting clinical conclusions regarding its biological behavior, and hence, the need for rigorous follow-up protocols. In this study, we review all cases of urinary bladder IP in our institution and determine the need for strict follow-up. Read More

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http://dx.doi.org/10.4103/0019-509X.73573DOI Listing
March 2011
37 Reads

Urothelial lesions with inverted growth patterns: histogenesis, molecular genetic findings, differential diagnosis and clinical management.

BJU Int 2011 Feb 23;107(4):532-7. Epub 2010 Nov 23.

Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.

A number of well-recognized urothelial lesions with inverted morphology occur in the urinary bladder. Some are so common that they are considered normal variants of urothelium, whereas others are rare. It is important for the surgical pathologist to recognize these lesions and their overlapping morphological features, because in some cases establishing an accurate diagnosis is challenging. Read More

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http://dx.doi.org/10.1111/j.1464-410X.2010.09853.xDOI Listing
February 2011
12 Reads

A cribriform urothelial neoplasm of the renal pelvis: an adenoid cysticlike variant of inverted urothelial papilloma or florid ureteritis cystica?

Arch Pathol Lab Med 2010 Oct;134(10):1557-9

Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 65198-3135, USA.

Tumors with cribriform appearance, similar to that of salivary gland adenoid cystic carcinoma, have been described at various anatomic sites. We present an unusual polypoid tumor, discovered incidentally, in the renal pelvis of an elderly man. The mass displayed a prominent cribriform architecture, akin to adenoid cystic carcinoma with an immunophenotype that supported a urothelial origin. Read More

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http://dx.doi.org/10.1043/2009-0483-CR.1DOI Listing
October 2010
30 Reads

[Urothelial carcinoma with an inverted growth pattern: a report of 4 cases].

Acta Med Croatica 2010 Mar;64(1):47-50

Department of Pathology, Sestre milosrdnice University Hospital, Zagreb, Croatia.

Aim: Urothelial (transitional cell) tumors account for about 90% of all bladder tumors. Their presentation varies from benign lesions that rarely recur to highly malignant tumors. Inverted (endophytic) growth pattern in urothelial carcinoma is particulary hard to distinguish from inverted papilloma. Read More

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March 2010
28 Reads

[Can inverted papilloma in urinary bladder be considered as a benign tumor].

Orv Hetil 2010 Jan;151(3):92-5

Semmelweis Egyetem, Altalános Orvostudományi Kar, Urológiai Klinika és Uroonkológiai Centrum, Budapest.

Unlabelled: Inverted papilloma of the urinary bladder is a rare entity. According to literature data, this disease is not malignant, and has low recurrence rate. Authors studied cases detected at the Urology Department and Urooncological Centrum at Semmelweis University in the last 11 years. Read More

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http://dx.doi.org/10.1556/OH.2010.28754DOI Listing
January 2010
43 Reads

Incidentally discovered inverted papilloma of the urinary bladder in patients with lower urinary tract symptoms.

J Endourol 2010 Feb;24(2):271-5

Department of Urology, Yonsei University Health System, Seoul, Korea.

Background And Purpose: Inverted urothelial papilloma (IP) is an uncommon urothelial neoplasm. We aimed to determine the clinicopathologic characteristics of IP of the bladder and its association with prostate volume and lower urinary tract symptoms (LUTS).

Patients And Methods: From 1994 to 2008, 53 patients with urinary IP underwent transurethral resection of the bladder tumor (TURBT) at our institution. Read More

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http://dx.doi.org/10.1089/end.2009.0354DOI Listing
February 2010
17 Reads

Human papillomavirus and p16 expression in inverted papillomas of the urinary bladder.

Cancer Lett 2010 Jun 29;292(2):171-5. Epub 2009 Dec 29.

Department of Pathology, Rush University, Chicago, USA.

Human Papillomaviruses (HPVs) have been found in association with benign and malignant growth of epithelia. The cell cycle inhibitor p16(Ink4a) has been shown to be overexpressed in HPV-positive cervical pre-malignant and malignant lesions, probably as a result of pRB targeting by the viral E7 protein. Inverted papillomas of the urinary bladder are epithelial tumors considered to be of benign nature. Read More

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http://linkinghub.elsevier.com/retrieve/pii/S030438350900692
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http://dx.doi.org/10.1016/j.canlet.2009.11.022DOI Listing
June 2010
41 Reads

Inverted urothelial papilloma of the urinary bladder with focal papillary pattern: a previously undescribed feature.

Ann Diagn Pathol 2009 Jun;13(3):158-61

Pathology Department, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubirán, Mexico City C.P. 14000, Mexico.

We report 2 examples of inverted urothelial papillomas with a focal papillary pattern. Both patients, a 43-year-old man and a 13-year-old adolescent boy, presented with hematuria. In addition to the characteristic trabecular endophytic growth pattern and bland cytologic features, the tumors showed focal papillary architecture in the endophytic component. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2009.02.009DOI Listing
June 2009
25 Reads

FGFR3 and TP53 mutation analysis in inverted urothelial papilloma: incidence and etiological considerations.

Mod Pathol 2009 May 13;22(5):627-32. Epub 2009 Mar 13.

Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

Urothelial papillomas and low-grade urothelial carcinomas have shown a high incidence of fibroblast growth factor receptor 3 (FGFR3) mutations and are associated with a favorable prognosis. The association of FGFR3 mutations with inverted papillomas is less known. We analyzed 20 cases of inverted papilloma in the urinary tract. Read More

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http://dx.doi.org/10.1038/modpathol.2009.28DOI Listing
May 2009
19 Reads

[Clinical and morphological features of a non-invasive papillary urothelial carcinoma, evolving from a urothelial inverted papilloma of the bladder].

Rev Med Chir Soc Med Nat Iasi 2009 Jan-Mar;113(1):150-3

Spitalul Judeţean de Urgenţă Suceava, Laboratorul de Anatomie Patologică.

The work presents the clinical and morphological aspects in a case of a non-invasive papillary urothelial carcinoma low grade developed on a bladder inverted papilloma from a patient aged 38 years. the tumour is distinguished by setting up at young age, female sex, by location on the side wall of the bladder and by rare association with inverted urothelial papilloma. Read More

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June 2011
14 Reads