25,137 results match your criteria Intravenous Immunoglobulin


Anakinra And Etanercept Combination Treatment in a Child With Severe, Nonresponsive Kawasaki Disease.

Pediatr Infect Dis J 2020 Jun 30. Epub 2020 Jun 30.

From the Department of Pediatric Cardiology and Pediatric Intensive Care, Ludwig-Maximilians-University of Munich, Marchioninistr. 15, 81377 Munich, Germany.

Kawasaki disease (KD) patients' resistance to treatment with intravenous immunoglobulins (IVIG) places them at high risk for an unfavorable progression of the disease. In these patients, there has been little evidence that alternative treatments are effective. Nevertheless, biologicals such as an interleukin-1-receptor blocker and tumor-necrosis-factor-α inhibitors increasingly have been used. Read More

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http://dx.doi.org/10.1097/INF.0000000000002810DOI Listing

GABA-B Receptor Encephalitis Triggered by Enterovirus Encephalitis in a Patient With Small Cell Lung Cancer: A Case Report.

Neurologist 2020 Jul;25(4):106-108

Department of Neurology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea.

Introduction: Encephalitis with gamma-aminobutyric acid (GABA)-B receptor antibodies (GABA-B receptor encephalitis) is known to have underlying neoplastic condition in half of the cases; however, there could be an additional event that could work as a trigger factor. Here, we report a patient with GABA-B receptor encephalitis associated with small cell lung cancer, which was probably triggered by enterovirus encephalitis.

Case Report: A 53-year-old man was admitted for a seizure, following fever and headache for 3 days. Read More

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http://dx.doi.org/10.1097/NRL.0000000000000283DOI Listing

Clinical and Laboratory Profile of Fatal Dengue Cases at a Tertiary Care Private Hospital in Mumbai, India.

Am J Trop Med Hyg 2020 Jul 6. Epub 2020 Jul 6.

Department of Critical Care, Kokilaben Dhirubhai Ambani Hospital and Medical Research Institute, Mumbai, India.

Dengue-related mortality has significantly reduced with early and appropriate fluid resuscitation. However, we continue to see dengue-related fatalities in patients despite early intervention and advanced critical care support. This was a retrospective study conducted at a tertiary care private hospital in Mumbai, India. Read More

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http://dx.doi.org/10.4269/ajtmh.19-0425DOI Listing

Long-term efficacy of immunoglobulins in small fiber neuropathy related to Sjögren's syndrome.

J Neurol 2020 Jul 1. Epub 2020 Jul 1.

Vascular and Coagulation Department, University Hospital Angers, Angers, France.

The most common peripheral nervous system manifestations in Sjogren's syndrome are small fiber sensory neuropathies (SFPN) and axonal sensorimotor polyneuropathies. Currently, treatment in small fiber neuropathy is mainly symptomatic and based on anti-depressors and anti-epileptics. The benefit of treatment with polyvalent immunoglobulins for SFPN has been reported in small series of patients, although transient in several cases. Read More

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http://dx.doi.org/10.1007/s00415-020-10033-zDOI Listing
July 2020
3.377 Impact Factor

Severe immune thrombocytopenic purpura in critical COVID-19.

Int J Hematol 2020 Jul 1. Epub 2020 Jul 1.

Department of Medicine - Critical Care Division, Centre hospitalier de I'Université de Montréal, Montréal, Canada.

COVID-19 is a new disease with many undescribed clinical manifestations. We report herein a case of severe immune thrombocytopenic purpura (ITP) in a critical COVID-19 patient. A patient presented a severe episode of immune thrombocytopenia (< 10 × 10/L) 20 days after admission for a critical COVID-19. Read More

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http://dx.doi.org/10.1007/s12185-020-02931-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327458PMC

Effects of Intravenous Immunoglobulin and Acyclovir in Preventing Neonatal Varicella.

Case Rep Infect Dis 2020 18;2020:2709389. Epub 2020 Jun 18.

Department of Family Medicine, Trang Hospital, 69 Khokkhan Rd, Tubtiang, Muang, Trang 92000, Thailand.

Neonatal varicella mostly results from maternal varicella. The disease can cause presentation ranging from mild symptoms to varicella pneumonia, hepatitis, meningoencephalitis, or fatality. If the mother develops symptoms implying varicella 4-5 days antepartum to 2 days postpartum, the mortality rate of the baby may reach 20%. Read More

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http://dx.doi.org/10.1155/2020/2709389DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320273PMC

Intravenous -acetylcysteine in severe cutaneous drug reaction treatment: A case series.

SAGE Open Med Case Rep 2020 20;8:2050313X20934708. Epub 2020 Jun 20.

Department of Internal Medicine and ICU, Square Hospitals Ltd., Dhaka, Bangladesh.

Drug-induced serious adverse reaction is an unpleasant event with high rate of mortality. Stevens-Johnson Syndrome and toxic epidermal necrolysis are most common among the serious adverse drug reactions. There is no selective drug therapy for the management of serious adverse drug reactions-associated mucocutaneous blisters. Read More

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http://dx.doi.org/10.1177/2050313X20934708DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7307482PMC

Successful treatment of refractory secondary immune thrombocytopenia (antiphospholipid antibody syndrome-associated) with the combination of rituximab and romiplostim at the cost of severe bone pain: A case report and review of literature.

J Oncol Pharm Pract 2020 Jul 1:1078155220935490. Epub 2020 Jul 1.

Department of Internal Medicine, Istanbul University-Cerrahpasa Faculty of Medicine, Istanbul, Turkey.

Introduction: Immune thrombocytopenia is an autoimmune disorder associated with increased thrombocyte destruction and impaired production in the bone marrow. Proposed mechanisms include an antibody or autoreactive T-cell-associated autoimmunity and thrombopoietin deficiency among others. Clinical manifestations are predominantly mucocutaneous hemorrhages including petechiae, purpura, mucosal bleeding in the urinary or the gastrointestinal tracts, menorrhagia, and epistaxis. Read More

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http://dx.doi.org/10.1177/1078155220935490DOI Listing

T-cell adoptive immunotherapy for BK nephropathy in renal transplantation.

Transpl Infect Dis 2020 Jul 1:e13399. Epub 2020 Jul 1.

Kidney Health Service, Royal Brisbane and Women's Hospital, Butterfield Street, Herston 4029, Queensland, Australia.

Introduction: BK virus (BKPyV) nephropathy occurs in 1-10% of kidney transplant recipients, with suboptimal therapeutic options.

Case: A 54-year-old received a transplant in March 2017. BKPyV was detected at 1. Read More

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http://dx.doi.org/10.1111/tid.13399DOI Listing

Anti-N-methyl-D-aspartate-receptor antibody encephalitis combined with syphilis: A case report.

World J Clin Cases 2020 Jun;8(12):2603-2609

Tianjin Key Laboratory of Cerebrovascular and Neurodegenerative Diseases, Tianjin Dementia Institute, Department of Neurology, Tianjin Huanhu Hospital, Tianjin 300350, China.

Background: Anti-N-methyl-D-aspartate-receptor (NMDAR) encephalitis is a common type of autoimmune encephalitis characterized by complex clinical signs and variable imaging manifestations. The pathogenesis of the disease is unclear. Syphilis is an infectious disease caused by that can invade the nervous and immune systems and cause systemic symptoms. Read More

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http://dx.doi.org/10.12998/wjcc.v8.i12.2603DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322422PMC

Drug-Induced Immune Thrombocytopenia From Administration of a Local Anesthetic Agent Resulting in Splenectomy.

Cureus 2020 May 26;12(5):e8293. Epub 2020 May 26.

Pathology, Penn State Health Milton S. Hershey Medical Center, Hershey, USA.

Thrombocytopenia is a common clinical condition, and drug-induced immune thrombocytopenia (DITP) should be considered in hospitalized patients with severe thrombocytopenia who are exposed to new medications. The potential mechanism is described to be drug-triggered antibody-mediated platelet destruction causing petechiae and mucosal bleeding. Severe form of DITP can be refractory to systemic steroids and even intravenous immunoglobulin administration. Read More

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http://dx.doi.org/10.7759/cureus.8293DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317117PMC

Tregitopes regulate the tolerogenic immune response and decrease the foetal death rate in abortion-prone mouse matings.

Sci Rep 2020 Jun 29;10(1):10531. Epub 2020 Jun 29.

Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, Poland.

The imbalance in immune tolerance may cause the variety of reproductive failures. An intravenous immunoglobulin infusion (IVIg) therapy is used to improve the live birth rate in women suffering from recurrent pregnancy loss, recurrent spontaneous abortions and recurrent implantation failures. However, the results of IVIg studies are still inconclusive as IVIg infusion in women suffering from pregnancy loss is sometimes ineffective. Read More

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http://dx.doi.org/10.1038/s41598-020-66957-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324366PMC

Case of Bickerstaff encephalitis with positive glutamic acid decarboxylase antibodies.

BMJ Case Rep 2020 Jun 29;13(6). Epub 2020 Jun 29.

Neurology, Airedale General Hospital, Keighley, West Yorkshire, UK.

Bickerstaff brainstem encephalitis (BBE) is a rare inflammatory demyelinating condition, which is similar to Miller-Fisher syndrome (MFS). Ophthalmoplegia and ataxia are common to these syndromes but unlike MFS, BBE is also characterised by central nervous system involvement, most commonly in the form of altered consciousness. BBE usually has a very good prognosis. Read More

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http://dx.doi.org/10.1136/bcr-2020-234814DOI Listing

Health status and infections in patients with symptomatic primary and secondary immunoglobulin G (IgG) deficiencies receiving intravenous IgG replacement.

BMC Immunol 2020 Jun 29;21(1):39. Epub 2020 Jun 29.

Institut für Versorgungsforschung in der Onkologie, Koblenz, Germany.

Background: The effects of intravenous immunoglobulin G replacement on perceived health and infection susceptibility of patients suffering from immunoglobulin G (IgG) deficiencies should be evaluated in a prospective analysis.

Methods: Patients with symptomatic primary or secondary IgG deficiencies were interviewed prior to the first IgG infusion (t) and over the course of their treatment (t - t). The respondents rated their current health using a 100 point scale (EQ-5D-5L), ranging from 0 ('worst imaginable health') to 100 ('best imaginable health'). Read More

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http://dx.doi.org/10.1186/s12865-020-00368-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325170PMC

Severe CIDP-MGUS responsive to Rituximab.

Heliyon 2020 Jun 18;6(6):e04230. Epub 2020 Jun 18.

Martin-Luther-University Halle-Wittenberg, Department of Neurology, Ernst-Grube-Straße 40, 06120, Halle (Saale), Germany.

Chronic inflammatory demyelinating polyneuropathy (CIDP) is a relatively rare disease with progressive limb weakness and sensory loss. A few patients show a severely progressing course without major response to intravenous immunoglobulin or plasma exchange therapy. CIDP-MGUS (monoclonal gammopathy of undetermined significance) is a seldom CIDP variant that has been rarely addressed in therapeutic studies. Read More

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http://dx.doi.org/10.1016/j.heliyon.2020.e04230DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306592PMC

Recent advances in managing and understanding Stevens-Johnson syndrome and toxic epidermal necrolysis.

F1000Res 2020 16;9. Epub 2020 Jun 16.

Division of Dermatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are life-threatening diseases characterized by detachment of the epidermis and mucous membrane. SJS/TEN are considered to be on the same spectrum of diseases with different severities. They are classified by the percentage of skin detachment area. Read More

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http://dx.doi.org/10.12688/f1000research.24748.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308994PMC

Myasthenia Gravis Can Have Consequences for Pregnancy and the Developing Child.

Authors:
Nils Erik Gilhus

Front Neurol 2020 12;11:554. Epub 2020 Jun 12.

Department of Clinical Medicine, University of Bergen, Bergen, Norway.

Myasthenia gravis (MG) with onset below 50 years, thymic hyperplasia and acetylcholine receptor (AChR) antibodies is more common in females than in males. For a relatively large group of MG patients, pregnancy represents therefore an important question. The muscle weakness, the circulating autoantibodies, the hyperplastic thymus, the MG drug treatment, and any autoimmune comorbidity may all influence both mother and child health during pregnancy and also during breastfeeding in the postpartum period. Read More

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http://dx.doi.org/10.3389/fneur.2020.00554DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7304249PMC

Recurrent Guillain-Barré and Fisher Syndromes in Two Patients Who Were Subsequently Diagnosed with Aplastic Anemia.

Case Rep Neurol 2020 May-Aug;12(2):148-152. Epub 2020 May 28.

Division of Cerebrovascular Medicine and Neurology, Clinical Research Institute, National Hospitalization Organization, Kyushu Medical Center, Fukuoka, Japan.

Guillain-Barré (GBS) and Fisher (FS) syndromes rarely recur and the characteristics of recurrence have not been fully elucidated. We describe the cases of 2 patients with GBS or FS that recurred more than twice and who were subsequently diagnosed with aplastic anemia. Case 1 was a 66-year-old man who was diagnosed with aplastic anemia 10 months before admission with limb ataxia and a sensory disturbance of the distal limbs that developed 3 days after an upper respiratory tract infection. Read More

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http://dx.doi.org/10.1159/000507778DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315140PMC

Cerebral Venous Thrombosis in a Patient with Immune Thrombocytopenia, an Apparent Paradox.

Case Rep Oncol 2020 May-Aug;13(2):588-594. Epub 2020 Jun 4.

Department of Medical Oncology, National Centre for Cancer Care and Research, Hamad Medical Corporation, Doha, Qatar.

We present a paradoxical case of immune thrombocytopenia (ITP) that presented with cerebral venous thrombosis. A 39-year-old female patient diagnosed with chronic ITP, who failed treatment on multiple-line agents, was started on eltrombopag (thrombopoietin receptor agonist), which she was not compliant to. The patient later developed extensive cerebral venous thrombosis, along with venous infarcts, and intracranial and subarachnoid hemorrhage. Read More

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http://dx.doi.org/10.1159/000507389DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315189PMC

THERAPEUTIC PLASMA EXCHANGE AND DOUBLE FILTRATION PLASMAPHERESIS IN SEVERE NEUROIMMUNE DISORDERS.

Acta Clin Croat 2019 Dec;58(4):621-626

1Lucian Blaga University, Faculty of Medicine, Sibiu, Romania; 2Department of Neurology, University Emergency County Hospital Sibiu, Sibiu, Romania; 3Department of Anesthesia, University Emergency County Hospital Sibiu, Sibiu, Romania.

Therapeutic plasma exchange (TPE) is an extracorporeal blood purification technique, which removes large molecular weight particles such as autoantibodies from plasma. TPE is accepted by the American Society for Apheresis as first line treatment for some severe neuroimmune disorders. Double filtration plasmapheresis (DFPP) is a newer technique in which plasma is not entirely removed, only the antibodies, using special filters. Read More

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http://dx.doi.org/10.20471/acc.2019.58.04.08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314295PMC
December 2019

Hematopoietic stem cell transplantation for chronic inflammatory demyelinating polyradiculoneuropathy.

J Neurol 2020 Jun 27. Epub 2020 Jun 27.

Academic Department of Neuroscience and Sheffield, NIHR Translational Neuroscience BRC, Sheffield Teaching Hospitals, NHS Foundation Trust, University of Sheffield, Sheffield, UK.

Objective: Determine toxicity and efficacy of autologous hematopoietic stem cell transplantation (HSCT) for patients with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) who are dependent on intravenous immunoglobulins or plasmapheresis.

Methods: Unselected peripheral blood stem cells were re-infused on day 0 after conditioning with cyclophosphamide 200 mg/kg/intravenously (IV), rATG (thymoglobulin) 5.5 mg/kg/IV, and rituximab 1000 mg/IV. Read More

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http://dx.doi.org/10.1007/s00415-020-10010-6DOI Listing

Acute Encephalopathy with Biphasic Seizures and Late Reduced Diffusion Associated with Dengue Infection in a Child.

J Trop Pediatr 2020 Jun 28. Epub 2020 Jun 28.

Department of Pediatrics, Sri Ramachandra Institute of Higher Education and Research, Porur, Chennai 600116, India.

Acute encephalopathy with biphasic seizures and late reduced diffusion (AESD) is a clinico-radiological syndrome in children secondary to viral or bacterial infections. The causes include viral (influenza, human herpes virus-6, adenovirus, rota) as well as bacterial infections. However, AESD with dengue infection has not been reported earlier. Read More

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http://dx.doi.org/10.1093/tropej/fmaa033DOI Listing

COVID-19 in children and adolescents in Europe: a multinational, multicentre cohort study.

Lancet Child Adolesc Health 2020 Jun 25. Epub 2020 Jun 25.

Department of Infection, Immunity and Inflammation, UCL Great Ormond Street Institute of Child Health, University College London, London, UK; Department of Paediatrics, Royal Children's Hospital Melbourne, University of Melbourne, Melbourne, Australia; Department of Paediatric Infectious Diseases & Immunology, Evelina London Children's Hospital, Guy's and St Thomas' NHS Foundation Trust, London, UK. Electronic address:

Background: To date, few data on paediatric COVID-19 have been published, and most reports originate from China. This study aimed to capture key data on children and adolescents with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection across Europe to inform physicians and health-care service planning during the ongoing pandemic.

Methods: This multicentre cohort study involved 82 participating health-care institutions across 25 European countries, using a well established research network-the Paediatric Tuberculosis Network European Trials Group (ptbnet)-that mainly comprises paediatric infectious diseases specialists and paediatric pulmonologists. Read More

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http://dx.doi.org/10.1016/S2352-4642(20)30177-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316447PMC

Treatment and follow-up of fetuses that developed congenital heart block due to autoantibody in two cases.

J Int Med Res 2020 Jun;48(6):300060520925596

Department of Echocardiography, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.

Objective: Autoantibody-related congenital heart block (ACHB) is a passively acquired autoimmune disease. This study aimed to examine the pathogenesis, clinical manifestations, and treatment of ACHB.

Method: The clinical data of two fetuses with first-degree ACHB were retrospectively analyzed. Read More

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http://dx.doi.org/10.1177/0300060520925596DOI Listing

Acute necrotizing encephalopathy with SARS-CoV-2 RNA confirmed in cerebrospinal fluid.

Neurology 2020 Jun 25. Epub 2020 Jun 25.

Department of Neuroscience, Neurosurgery, Uppsala University, Uppsala, Sweden

Here we report a case of Covid-19-related acute necrotizing encephalopathy (ANE) where SARS-CoV-2 RNA was found in cerebrospinal fluid (CSF) 19 days after symptom onset after testing negative twice. Even though monocytes and protein levels in CSF were only marginally increased, and our patient never experienced a hyperinflammatory state, her neurological function deteriorated into coma. Magnetic resonance imaging of the brain showed pathological signal symmetrically in central thalami, subinsular regions, medial temporal lobes and brain stem. Read More

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http://dx.doi.org/10.1212/WNL.0000000000010250DOI Listing

Human and novel coronavirus infections in children: a review.

Paediatr Int Child Health 2020 Jun 25:1-20. Epub 2020 Jun 25.

Division of Infectious Diseases, Department of Pediatrics and Internal Medicine, University of Saskatchewan , Saskatoon, Saskatchewan, Canada.

Coronaviruses, seven of which are known to infect humans, can cause a spectrum of clinical presentations ranging from asymptomatic infection to severe illness and death. Four human coronaviruses (hCoVs)-229E, HKU1, NL63 and OC43-circulate globally, commonly infect children and typically cause mild upper respiratory tract infections. Three novel coronaviruses of zoonotic origin have emerged during the past two decades: severe acute respiratory syndrome coronavirus (SARS-CoV-1), Middle East respiratory syndrome coronavirus (MERS-CoV) and the recently discovered severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) which is the cause of the ongoing coronavirus disease 2019 (COVID-19) pandemic. Read More

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http://dx.doi.org/10.1080/20469047.2020.1781356DOI Listing

Diagnosis and treatment of chronic inflammatory demyelinating polyradiculoneuropathy in clinical practice: a survey among Dutch neurologists.

J Peripher Nerv Syst 2020 Jun 24. Epub 2020 Jun 24.

Department of Neurology, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands.

The diagnosis and treatment of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is often a challenge. The clinical presentation is diverse, accurate biomarkers are lacking, and the best strategy to initiate and maintain treatment is unclear. The aim of this study was to determine how neurologists diagnose and treat CIDP. Read More

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http://dx.doi.org/10.1111/jns.12399DOI Listing

Systematic literature review of burden of illness in chronic inflammatory demyelinating polyneuropathy (CIDP).

J Neurol 2020 Jun 24. Epub 2020 Jun 24.

CSL Behring, Hattersheim, Germany.

Background: Chronic inflammatory demyelinating polyneuropathy (CIDP) is a rare neurological disorder characterised by muscle weakness and impaired sensory function. The present study provides a comprehensive literature review of the burden of illness of CIDP.

Methods: Systematic literature search of PubMed, Embase, and key conferences in May 2019. Read More

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http://dx.doi.org/10.1007/s00415-020-09998-8DOI Listing

A novel mutation in RFXANK gene and low B cell count in a patient with MHC class II deficiency: a case report.

Immunol Res 2020 Jun 23. Epub 2020 Jun 23.

Department of Immunology, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Recurrence of severe microbial infections results from a primary immunodeficiency disorder known as major histocompatibility complex class II deficiency or bare lymphocyte syndrome type II. Immunologic function is severely impaired due to the absence of MHC class II molecules on the surface of immune cells. Here, we report a 5-year-old boy with a novel homozygous mutation in RFXANK gene that negatively affects the proper expression of MHC class II molecules by antigen presenting cells. Read More

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http://dx.doi.org/10.1007/s12026-020-09141-9DOI Listing
June 2020
3.098 Impact Factor

Kikuchi-Fujimoto disease complicated by aseptic meningitis and hemophagocytosis successfully treated with intrathecal dexamethasone.

Heliyon 2020 Jun 18;6(6):e04193. Epub 2020 Jun 18.

Department of Rheumatology, The University of Hong Kong- Shenzhen Hospital, Shenzhen, 518053, China.

Kikuchi-Fujimoto disease (KFD) is thought to be a self-limited disease featuring fever and cervical lymphadenopathy; most cases having a favorable outcome. Severe disease and death are occasionally reported. Here we report a case of KFD complicated by hemophagocytosis and aseptic meningitis. Read More

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http://dx.doi.org/10.1016/j.heliyon.2020.e04193DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7305385PMC

Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Children With Non-Hodgkin Lymphoma.

J Pediatr Hematol Oncol 2020 Jul;42(5):e310-e314

Departments of Pediatric Hematology and Oncology.

The aim of this study is to evaluate the clinical and laboratory findings of pediatric patients with non-Hodgkin lymphoma (NHL) who developed Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). Between 2006 and 2018, the medical records of child patients with NHL who developed SJS and TEN were reviewed retrospectively. SJS/TEN developed in 7 of 70 patients with NHL (10%). Read More

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http://dx.doi.org/10.1097/MPH.0000000000001851DOI Listing

IMMUNOGLOBULIN PREPARATIONS CAN MISLEAD CLINICAL DECISION-MAKING IN FOLLOW-UP OF DIFFERENTIATED THYROID CANCER.

Endocr Pract 2020 Jun 23. Epub 2020 Jun 23.

Université de Lorraine, CHRU-Nancy, Department of Endocrinology, Diabetology and Nutrition, Nancy, F-54000, France.

Intravenous and subcutaneous immunoglobulins are commonly used for immune substitution or as immune modulators in a variety of inflammatory and autoimmune disorders. Exogenous thyroid specific thyroglobulin antibodies present in the donor plasma may interfere with the interpretation of measurements of autoantibodies to thyroglobulin in the recipient's plasma and potentially trigger immune response in recipient's immune cells. Levels of antibodies causing bioassay interferences or those leading to clinically relevant changes in patient-outcomes are not known. Read More

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http://dx.doi.org/10.4158/EP-2020-0053DOI Listing

Considerations for Optimizing Dosing of Immunoglobulins Based on Pharmacokinetic Evidence.

Antibodies (Basel) 2020 Jun 19;9(2). Epub 2020 Jun 19.

Division of Plasma Protein Therapeutics, Office of Tissue and Advanced Therapies (OTAT), Center for Biologics Evaluation and Research (CBER), Food & Drug Administration (FDA), 10903 New Hampshire Avenue, Silver Spring, MD 20993-0002, USA.

Immunoglobulins (IGs) are widely used for the treatment of immunodeficiency syndromes and several autoimmune diseases. In neonates, IGs have been used for the treatment of alloimmune thrombocytopenia, in neonatal infections and in the rare cases of neonatal Kawasaki disease. This review aims to examine the various dosing regimens of IGs following intravenous (IV) and subcutaneous (SC) administration, pharmacokinetics (PK) of IGs, and the importance of trough values for the prevention of infections in patients with primary immune deficiency (PID). Read More

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http://dx.doi.org/10.3390/antib9020024DOI Listing

Immunoadsorption for Treatment of Patients with Suspected Alzheimer Dementia and Agonistic Autoantibodies against Alpha1a-Adrenoceptor-Rationale and Design of the IMAD Pilot Study.

J Clin Med 2020 Jun 19;9(6). Epub 2020 Jun 19.

Department of Internal Medicine B, University Medicine Greifswald, Ferdinand-Sauerbruch-Straße, 17475 Greifswald, Germany.

Background: agonistic autoantibodies (agAABs) against G protein-coupled receptors (GPCR) have been linked to cardiovascular disease. In dementia patients, GPCR-agAABs against the α1- and ß2-adrenoceptors (α1AR- and ß2AR) were found at a prevalence of 50%. Elimination of agAABs by immunoadsorption (IA) was successfully applied in cardiovascular disease. Read More

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http://dx.doi.org/10.3390/jcm9061919DOI Listing

Kawasaki-like diseases and thrombotic coagulopathy in COVID-19: delayed over-activation of the STING pathway?

Emerg Microbes Infect 2020 Jun 23:1-26. Epub 2020 Jun 23.

Rheumatology Department & Inserm UMR 1132 (centre Viggo Petersen) Hôpital Lariboisière, 2 rue Ambroise Paré, F-75010 Paris Université de Paris, UFR de Médecine, F-75010 Paris, France E-mail:

As healthy young adults can die of COVID-19, whereas old COVID-19 patients can have mild symptoms only, genetic variances probably contribute to the severity of this emerging infection. We previously put forward the hypothesis that gain of function variants of , which encodes STING, contribute to COVID-19, since bats are protected from coronaviruses due to loss of function mutations of this gene. The present review detail new arguments for the contribution of the STING pathway to COVID-19, following the description of hyper-coagulability and Kawasaki-like diseases in children with COVID-19. Read More

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http://dx.doi.org/10.1080/22221751.2020.1785336DOI Listing

Mouse Models of Rheumatoid Arthritis for Studies on Immunopathogenesis and Preclinical Testing of Fc Receptor-Targeting Biologics.

Pharmacology 2020 Jun 22:1-12. Epub 2020 Jun 22.

Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada,

Background: Rheumatoid arthritis (RA) is a chronic autoimmune disease that causes inflammation, swelling, and pain in the joints and involves systemic complications. Mouse models of RA have been extensively used to model the pathogenesis of RA and to develop effective therapies. Although many components of the immune system have been studied in these models, the role of crystallizable fragment (Fc) gamma receptors (FcγRs) in RA has been sorely neglected. Read More

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http://dx.doi.org/10.1159/000508239DOI Listing

Pharmacological development of the potential adjuvant therapeutic agents against coronavirus disease 2019.

J Chin Med Assoc 2020 Jun 15. Epub 2020 Jun 15.

Department of Pharmacy, Taipei Veterans General Hospital, Taipei, Taiwan, ROC.

As the coronavirus disease 2019 (COVID-19, also called severe acute respiratory syndrome coronavirus-2, SARSCoV-2) outbreak accelerates, vigorous and diverse efforts were made in developing treatment strategies. In addition to direct acting agents, increasing evidence showed some potential adjuvant therapies with promising efficacy against COVID-19. These therapies include immunomodulators (i. Read More

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http://dx.doi.org/10.1097/JCMA.0000000000000375DOI Listing

Effectiveness of intravenous immunoglobulin for children with severe COVID-19: a rapid review.

Ann Transl Med 2020 May;8(10):625

Department of Respiratory Medicine, Children's Hospital of Chongqing Medical University, Chongqing 400014, China.

Background: Intravenous immunoglobulin (IVIG) is usually used as supportive therapy, but the treatment of COVID-19 by IVIG is controversial. This rapid review aims to explore the clinical effectiveness and safety of IVIG in the treatment of children with severe COVID-19.

Methods: We systematically searched the literature on the use of IVIG in patients with COVID-19, severe acute respiratory syndrome (SARS) or Middle East respiratory syndrome (MERS), including both adults and children. Read More

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http://dx.doi.org/10.21037/atm-20-3305DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290641PMC

Treatment of parvovirus B19 viremia to facilitate kidney transplantation in a patient with collapsing glomerulopathy.

Clin Nephrol Case Stud 2020 29;8:41-45. Epub 2020 May 29.

Department of Surgery, and.

Collapsing glomerulopathy (CG) is a severe form of glomerulopathy which results in nephrotic syndrome and often ensues in rapid progression to end-stage kidney disease (ESKD). Although most commonly a result of HIV infection, other conditions such as parvovirus B19 (PB19) infection have been associated with CG. We present a case of an 18-year-old male with CG associated with PB19 infection who was heterozygous for G1 and G2 genetic variants. Read More

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http://dx.doi.org/10.5414/CNCS110113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303543PMC

Immune Checkpoint Inhibitor-Mediated Myasthenia Gravis.

J Emerg Med 2020 Jun 18. Epub 2020 Jun 18.

Department of Acute Medicine and Critical Care, The Christie, NHS Foundation Trust, Manchester, United Kingdom.

Background: Immune checkpoint inhibitors (ICIs) have a wide range of toxicities affecting potentially any organ system stemming from increased activity within the T-cell lineage similar to that observed in autoimmunity.

Case Report: A 57-year-old man with metastatic papillary renal cell carcinoma treatment with combination ICI therapy presented with a history of rapidly progressive diplopia. Neurological examination revealed bilateral fatigable ptosis and asymmetrical ophthalmoplegia. Read More

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http://dx.doi.org/10.1016/j.jemermed.2020.05.004DOI Listing
June 2020
1.175 Impact Factor

Letter to the editor: efficacy of different methods of combination regimen administrations including dexamethasone, intravenous immunoglobulin, and interferon-beta to treat critically ill COVID-19 patients: a structured summary of a study protocol for a randomized controlled trial.

Trials 2020 Jun 19;21(1):549. Epub 2020 Jun 19.

Golestan Research Center of Gastroenterology and Hepatology, Golestan University of Medical Sciences, Gorgan, Iran.

Objectives: There is little information about Coronavirus Disease 2019 (COVID-19) management for critically ill patients. Most of these patients develop acute respiratory distress syndrome (ARDS) due to excessive inflammatory response and the ensuing cytokine storm. Anti-inflammatory drugs including corticosteroids can be used to effectively reduce the effect of this cytokine storm and lung damage. Read More

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http://dx.doi.org/10.1186/s13063-020-04499-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303932PMC

Immediate adverse reactions to intravenous immunoglobulin in primary immune deficiencies: a single center experience.

Turk J Pediatr 2020 ;62(3):379-386

Division of Pediatric Allergy and Immunology, Department of Pediatrics, Marmara University Faculty of Medicine, İstanbul, Turkey.

Background And Objective: Adverse reactions related to intravenous immunoglobulin (IVIG) infusions vary from 1 to 81%, with an average of 20%. They may be classified as immediate; occurring during the infusion itself or delayed; occurring after the infusion has been ceased. In the present study, we aimed to evaluate the frequency of immediate adverse reactions due to IVIG infusions in primary immune deficiency (PID) patients. Read More

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http://dx.doi.org/10.24953/turkjped.2020.03.004DOI Listing
January 2020

Multisystem Inflammatory Syndrome in Children (MIS-C) Associated with SARS-CoV-2 Infection: A Multi-institutional Study from New York City.

J Pediatr 2020 Jun 14. Epub 2020 Jun 14.

Department of Pediatrics, Division of Pediatric Critical Care Medicine, Albert Einstein College of Medicine, Children's Hospital at Montefiore; Department of Pediatrics, Division of Pediatric Cardiology, Albert Einstein College of Medicine, Children's Hospital at Montefiore. Electronic address:

Objective: To assess clinical characteristics and outcomes of SARS-CoV-2 associated multisystem inflammatory syndrome in children (MIS-C).

Study Design: Children with MIS-C admitted to pediatric intensive care units (PICU) in New York City between April 23 and May 23, 2020 were included. Demographic and clinical data were collected. Read More

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http://dx.doi.org/10.1016/j.jpeds.2020.06.045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293760PMC
June 2020
3.790 Impact Factor

Are Repeated Cycles of Intravenous Immunoglobulin Justified in Patients With Poorly Responsive Guillain-Barré Syndrome?

Neurohospitalist 2020 Jul 13;10(3):224-228. Epub 2019 Dec 13.

Aseer Central Hospital, Abha, Saudi Arabia.

Guillain-Barré syndrome (GBS) is a life-threatening form of inflammatory polyneuropathy. Immunotherapy with intravenous immunoglobulin (IVIG) has been used successfully in the treatment of GBS. In this case report, we present a severe axonal form of GBS that showed improvement after 3 cycles of IVIG. Read More

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http://dx.doi.org/10.1177/1941874419893570DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7271620PMC

IgG from atopic individuals can mediate non-atopic infant thymic and adult peripheral CD8 + TC2 skewing without influence on TC17 or TC22 cells.

Eur Ann Allergy Clin Immunol 2020 06 17. Epub 2020 Jun 17.

Laboratory of Medical Investigation LIM-56, Division of Clinical Dermatology, Medical School, University of São Paulo, São Paulo, Brazil.

The potential of IgG antibodies as allergy regulators has been discussed for decades and was brought to light that anti-allergen IgG is related to allergy inhibition in children during the first years of life and that IgG repertoire can differ between atopic and non-atopic individuals. Here, we aimed to evaluate in vitro the differential effects of purified IgG from atopic and non-atopic individuals on the production of IL-4, IL-17, and IL-22 by human intra-thymic and mature peripheral CD8+ T cells respectively termed as TC2, TC17, and TC22 cells. We additionally evaluated the IFN-ã production by CD8+ T cells. Read More

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http://dx.doi.org/10.23822/EurAnnACI.1764-1489.157DOI Listing

Clinical characteristics, diagnosis, and treatment of COVID-19: A case report.

World J Clin Cases 2020 Jun;8(11):2325-2331

Department of Respiratory and Critical Care Medicine, Changhai Hospital, Naval Medical University, Shanghai 200433, China.

Background: Since December 2019, many cases of pneumonia caused by novel coronavirus have been discovered in Wuhan, China, and such cases have spread nationwide quickly. At present, coronavirus disease 2019 (COVID-19) is a worldwide pandemic. What are the clinical features of this disease? What is the clinical diagnosis and how should such patients be treated? As a clinician, mastery of the clinical characteristics, basic diagnosis, and treatment methods of COVID-19 are required to provide help to patients. Read More

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http://dx.doi.org/10.12998/wjcc.v8.i11.2325DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281032PMC

CT Coronary Angiography Studies After a Mean Follow-up of 3.8 Years in Children With Kawasaki Disease and Spontaneous Defervescence.

Front Pediatr 2020 28;8:274. Epub 2020 May 28.

Allergy Immunology Unit, Department of Pediatrics, Advanced Pediatrics Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

There is paucity of literature on follow-up of children with Kawasaki disease (KD) who have spontaneous defervescence during the acute stage and do not receive intravenous immunoglobulin. We report herein the role of computed tomography coronary angiography (CTCA) as an imaging modality in such situations. This prospective observational study was carried out during the period January 2016-June 2017. Read More

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http://dx.doi.org/10.3389/fped.2020.00274DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7270275PMC

AMBAR, an Encouraging Alzheimer's Trial That Raises Questions.

Authors:
David A Loeffler

Front Neurol 2020 29;11:459. Epub 2020 May 29.

Beaumont Research Institute, Department of Neurology, Beaumont Health, Royal Oak, MI, United States.

Grifols' recent Alzheimer Management by Albumin Replacement ("AMBAR") study investigated the effects of plasmapheresis with albumin replacement, plus intravenous immunoglobulin (IVIG) in some subjects, in patients with mild-to-moderate Alzheimer's disease (AD). AMBAR was a phase IIb trial in the United States and a phase III trial in Europe. There were three treatment groups (plasmapheresis with albumin replacement; plasmapheresis with low dose albumin and IVIG; plasmapheresis with high dose albumin and IVIG) and sham-treated controls. Read More

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http://dx.doi.org/10.3389/fneur.2020.00459DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7272580PMC

Prevalence and Management of Severe Hand, Foot, and Mouth Disease in Xiangyang, China from 2008-2013.

Authors:
Jian Liu Jing Qi

J Med Virol 2020 Jun 16. Epub 2020 Jun 16.

Department of Neurology, Affiliated Shenzhen Baoan Hospital, Southern Medical University.

Therapeutic strategies for severe hand, foot, and mouth disease (HFMD) are currently either inconsequent or deficient in evidence. We retrospectively surveyed HFMD outbreaks in Xiangyang from June 2008 to December 2013. HFMD is staged form I to V according to clinical severity and the case with central nervous system involvement is defined as a severe one. Read More

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http://dx.doi.org/10.1002/jmv.26186DOI Listing
June 2020
2.347 Impact Factor