26,884 results match your criteria Intravenous Immunoglobulin

Multisystem inflammatory syndrome in children with COVID-19.

Am J Emerg Med 2021 Jun 8;49:148-152. Epub 2021 Jun 8.

Department of Emergency Medicine, Brooke Army Medical Center, USA.

Background: Multisystem inflammatory syndrome in children (MIS-C) is a dangerous pediatric complication of COVID-19.

Objective: The purpose of this review article is to provide a summary of the diagnosis and management of MIS-C with a focus on management in the acute care setting.

Discussion: MIS-C is an inflammatory syndrome which can affect nearly any organ system. Read More

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Guillain-Barré syndrome variant occurring after SARS-CoV-2 vaccination.

Ann Neurol 2021 Jun 10. Epub 2021 Jun 10.

Department of Neurology, Nottingham University Hospitals NHS Trust, Nottingham, UK.

Whilst SARS-CoV-2 vaccines are very safe, we report four cases of the bifacial weakness with paraesthesias variant of Guillain-Barré syndrome (GBS) occurring within three weeks of vaccination with the Oxford-AstraZeneca SARS-CoV-2 vaccine. This rare neurological syndrome has previously been reported in association with SARS-CoV-2 infection itself. Our cases were given either intravenous immunoglobulin, oral steroids, or no treatment. Read More

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COVID-19 in the Context of Inborn Errors of Immunity: a Case Series of 31 Patients from Mexico.

J Clin Immunol 2021 Jun 10. Epub 2021 Jun 10.

Immune Deficiencies Lab., National Institute of Pediatrics, Av Iman 1, Torre de Investigacion Piso 9, Insurgentes Cuicuilco, Coyoacan, 04530, Mexico City, Mexico.

Introduction: Patients with inborn errors of immunity (IEI) have a compromised or inappropriate immune response. Although they might be considered a high-risk group for severe SARS-CoV-2 infection, the reported impact of COVID-19 in these patients has been reassuring, while the differential susceptibility of distinct types of IEI remains unclear.

Objective: We aimed to describe the findings and outcomes of our known patients with IEI who were diagnosed with COVID-19. Read More

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Unusual Bilateral Upper Extremity Pitting Edema in a Patient With Severe Dermatomyositis.

Cureus 2021 Jun 4;13(6):e15445. Epub 2021 Jun 4.

Rheumatology, Adventist Medical Center, Hanford, USA.

A 56-year-old Hispanic female presented with six weeks of progressive dysphagia, proximal muscle weakness, erythematous rash, bilateral upper extremity pitting edema, and left lower extremity pitting edema. She had preserved heart function and a normal echocardiogram (ECG). She presented with elevated creatine kinase (CK) and aldolase, with normal renal function. Read More

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Guillain-Barré Syndrome With a Peculiar Course: A Case Report.

Cureus 2021 May 8;13(5):e14905. Epub 2021 May 8.

Pediatrics, Emergency Clinical Hospital for Children, Cluj-Napoca, ROU.

Guillain-Barré syndrome (GBS) or acute inflammatory demyelinating polyradiculoneuropathy (AIDP) is a rare autoimmune disorder in which the body's immune system mistakenly attacks the nerves. In this report, we present a case of a 15-month-old girl who presented with an inability to walk and support the vertical and sitting positions, pain in the lower limbs accompanied by grimaces, muscular weakness, and agitation due to gait disturbances. This is a unique case in that GBS affected a previously healthy girl and was associated with pneumonia and anemia as the disease progressed, causing an intriguing diagnosis. Read More

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Case Report: Severe Adolescent Major Depressive Syndrome Turns Out to Be an Unusual Case of Anti-NMDA Receptor Encephalitis.

Front Psychiatry 2021 25;12:679996. Epub 2021 May 25.

Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.

Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a neuroinflammatory condition mediated by autoantibodies against the GluN1 subunit of the receptor. Clinically, it is characterized by a complex neuropsychiatric presentation with rapidly progressive psychiatric symptoms, cognitive deficits, seizures, and abnormal movements. Isolated psychiatric manifestations of anti-NMDAR encephalitis are rare and usually dominated by psychotic symptoms. Read More

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Diagnostic and treatment recommendations from the FACME ad-hoc expert working group on the management of cerebral venous sinus thrombosis associated with COVID-19 vaccination.


Neurologia (Engl Ed) 2021 May 29. Epub 2021 May 29.

Introduction: Cases of cerebral venous sinus thrombosis have been reported in individuals vaccinated against COVID-19 with non-replicating adenoviral vector vaccines. We issue our recommendations on the diagnosis and management of patients presenting this complication.

Methods: The multidisciplinary working group, led by the Spanish Federation of Medical and Scientific Associations (FACME) and including representatives of several scientific societies, reviewed the available evidence from the literature and reports of the European Medicines Agency. Read More

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Hyperimmune anti-COVID-19 IVIG (C-IVIG) treatment in severe and critical COVID-19 patients: A phase I/II randomized control trial.

EClinicalMedicine 2021 Jun 4:100926. Epub 2021 Jun 4.

Dow University of Health Sciences - Ojha Campus, Karachi, Pakistan.

Background: Hyperimmune anti-COVID-19 Intravenous Immunoglobulin (C-IVIG) is an unexplored therapy amidst the rapidly evolving spectrum of medical therapies for COVID-19 and is expected to counter the three most life-threatening consequences of COVID-19 including lung injury by the virus, cytokine storm and sepsis.

Methods: A single center, phase I/II, randomized controlled, single-blinded trial was conducted at Dow University of Health Sciences, Karachi, Pakistan. Participants were COVID-19 infected individuals, classified as either severely or critically ill with Acute Respiratory Distress Syndrome (ARDS). Read More

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A Systematic Review and Meta-Analysis of Autoantibodies for Diagnosis and Prognosis in Patients With Chronic Inflammatory Demyelinating Polyradiculoneuropathy.

Front Neurosci 2021 24;15:637336. Epub 2021 May 24.

Department of Neurology, The Second Xiangya Hospital, Central South University, Changsha, China.

To review the available evidence on sensitivity and specificity of anti-NF155 antibody detection in diagnosing a specific subset of patients with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) and to calculate the frequencies of different autoantibodies to paranodal proteins. Diagnosis of CIDP relies on clinical and neurophysiologic criteria and lacks useful diagnostic biomarkers. A subset of CIDP patients exhibit atypical clinical phenotypes and impaired response to conventional treatments. Read More

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Yersinia pseudotuberculosis Infection Accompanied by Intussusception and Incomplete Kawasaki Disease in a 7-year-old Girl.

Keio J Med 2021 Jun 8. Epub 2021 Jun 8.

Department of Pediatrics, National Hospital Organization Saitama Hospital, Saitama, Japan.

Infection with Yersinia pseudotuberculosis, a known causal pathogen of human bacterial gastroenteritis, causes various symptoms and complications. A previously healthy 7-year-old girl was admitted because of fever and gastrointestinal symptoms. She was initially diagnosed with intussusception by abdominal ultrasonography. Read More

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Diagnosis and Management of Myocarditis: An Evidence-Based Review for the Emergency Medicine Clinician.

J Emerg Med 2021 Jun 6. Epub 2021 Jun 6.

Department of Emergency Medicine, Brooke Army Medical Center, Fort Sam Houston, Texas.

Background: Myocarditis is a potentially fatal condition that can be misdiagnosed in the emergency department (ED) setting.

Objective: The purpose of this narrative review article is to provide a summary of the background, pathophysiology, diagnosis, and management of myocarditis, with a focus on emergency clinicians.

Discussion: Myocarditis occurs when inflammation of the heart musculature causes cardiac dysfunction. Read More

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Stratified therapy for Kawasaki disease using a new scoring system to predict the response to a lower dose of intravenous immunoglobulin therapy.

Cardiol Young 2021 Jun 10:1-5. Epub 2021 Jun 10.

Department of Pediatrics, Saitama Medical Center, Jichi Medical University, Saitama, Japan.

Background: Several studies have reported treatment options for patients with Kawasaki disease refractory to standard immunoglobulin therapy; however, no studies have reported low-dose immunoglobulin therapy for patients with a low risk of Kawasaki disease.

Methods: A total of 277 patients with Kawasaki disease were included in this study. We used Kobayashi score and our Less high-risk score to divide the patients into three groups. Read More

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A clinical study of lyophilized intravenous human immunoglobulin containing high-titer cytomegalovirus-neutralizing antibody for the treatment of cytomegalovirus viremia after allogeneic hematopoietic stem cell transplantation.

Ann Palliat Med 2021 May;10(5):5533-5540

State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China.

Background: Cytomegalovirus (CMV) infection increases the risk of death after allogeneic hematopoietic stem cell transplantation (allo-HSCT). However, some patients do not respond to ganciclovir (GCV) or foscarnet sodium. Lyophilized intravenous human immunoglobulin containing high-titer CMV-neutralizing antibody (CMV-IVIG) is another option to further improve treatment safety and efficacy. Read More

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Kawasaki like illness due to COVID-19: a review of the literature.

J Infect Dev Ctries 2021 05 31;15(5):630-638. Epub 2021 May 31.

Divisions of Infectious Diseases and Hematology/Oncology, Medical College of Wisconsin, Milwaukee, WI, United States.

Introduction: Viral infections have been described as triggers for Kawasaki Disease (KD), a medium vessel vasculitis that affects young children. Akin to the H1N1 pandemic in 2009, there is a similar rise in the incidence of KD in children affected with Coronavirus disease 2019 (COVID-19). Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-COV-2) has been reported to induce an exaggerated systemic inflammatory response resulting in multi-organ involvement, particularly initiated with pulmonary parenchymal damage. Read More

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Multisystem Inflammatory Syndrome in Children (MISC): a systematic review.

Int J Clin Pract 2021 Jun 9:e14450. Epub 2021 Jun 9.

Faculty of Medicine, University of Porto, Porto, Portugal, Alameda Prof. Hernâni Monteiro, 4200-319, Porto, Portugal.

Objective: Analyze current literature and reported cases of MISC, concerning its clinical spectrum, complications associated, therapeutic strategies and distinguishing features of other clinical syndromes.

Methods: Extensive literature research was performed in MEDLINE (trough PubMed), Scopus and Web of Science from December 2019 to December 2020. First analysis included all article titles and abstracts screening to identify relevant studies and second analysis included a full text screening of previous selected studies. Read More

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[Influencing Factors in the Chronicity of Immune Thrombocytopenia in Children].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2021 Jun;29(3):881-886

Department of Pediatric Hematology, The Second Affiliated Hospital of Anhui Medical University, Hefei 230601, Anhui Province, China,E-mail: zwnltt

Objective: To explore the influencing factors in children with chronicity immune thrombocytopenia (ITP), and to provide basis for judging the prognosis and treatment in children with ITP.

Methods: The clinical data of children with ITP admitted to The Second Affiliated Hospital of Anhui Medical University in the past 5 years were retrospectively analyzed and followed up for more than 1 year. According to the inclusion criteria, the eligible cases (328 cases in total) were selected and collected through medical record system retrieval, outpatient clinic and telephone follow-up. Read More

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Multisystemic inflammatory syndrome in children associated with COVID-19: a single center experience in Turkey.

Turk Arch Pediatr 2021 1;56(3):192-199. Epub 2021 May 1.

Division of Cardiology, Department of Pediatrics, Kocaeli University, Kocaeli, Turkey.

Objective: Multisystem inflammatory syndrome in children (MIS-C) associated with the coronavirus disease 2019 (COVID-19) is a new concern emerging as a severe presentation of COVID-19 in children. We aimed to describe the characteristics and short-term outcomes of children diagnosed with MIS-C.

Material And Methods: A retrospective study was conducted on 24 patients who were diagnosed with MIS-C between June 1, 2020 and December 1, 2020. Read More

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Gastroenteritis and cardiogenic shock in a healthcare worker: a case report of COVID-19 myocarditis confirmed with serology.

Eur Heart J Case Rep 2021 Feb 8;5(2):ytab013. Epub 2021 Feb 8.

Department of Cardiology, Hammersmith Hospital, Imperial College Healthcare NHS Trust, London, W12 0HS, UK.

Background: Coronavirus disease 2019 (COVID-19) myocarditis is emerging as a component of the hyperactive inflammatory response secondary to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Isolated gastrointestinal symptoms are uncommon presenting features in adults with COVID-19 myocarditis. The availability of antibody testing is a valuable addition to the confirmation of COVID-19, when repeated reverse transcriptase-polymerase chain reaction of nasopharyngeal swabs are negative. Read More

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February 2021

Egyptian clinical practice guideline for kidney transplantation.

Arab J Urol 2021 Jan 3;19(2):105-122. Epub 2021 Jan 3.

Nephrology Department, Kasr El-Einy Medical School, Cairo University, Cairo, Egypt.

: To present the first Egyptian clinical practice guideline for kidney transplantation (KT). : A panel of multidisciplinary subspecialties related to KT prepared this document. The sources of information included updates of six international guidelines, and review of several relevant international and Egyptian publications. Read More

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January 2021

Profile of Kawasaki disease at a tertiary care center in India.

Ann Pediatr Cardiol 2021 Apr-Jun;14(2):187-191. Epub 2021 Feb 16.

Department of Cardiac Sciences, Division of Pediatric Cardiology, Aster CMI Hospital, Bengaluru, Karnataka, India.

Background: Kawasaki disease (KD) is the most common cause of acquired heart disease in developed countries. KD is increasingly being reported from India; however, studies involving the large number of patients are few.

Methods: All children presenting to the center from January 2017 to December 2019, diagnosed to have KD, were retrospectively included in the study. Read More

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February 2021

Evaluation of high-dose aspirin elimination in the treatment of Kawasaki disease in the incidence of coronary artery aneurysm.

Ann Pediatr Cardiol 2021 Apr-Jun;14(2):146-151. Epub 2021 Apr 16.

Social Determinants of Health Research Center, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran.

Background: Standard first-step therapy for Kawasaki disease consists of Intravenous immunoglobulin and high dose Aspirin (80-100 mg/kg/day). The standard dose of Intravenous immunoglobulin (2gr/kg) is strongly effective in reducing the risk of coronary arteries abnormalities. So, the proper dose and efficacy of Aspirin to decrease the risk of coronary arteries abnormalities is a controversial issue. Read More

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Intravenous immunoglobulin treatment for mild Guillain-Barré syndrome: an international observational study.

J Neurol Neurosurg Psychiatry 2021 Jun 8. Epub 2021 Jun 8.

Department of Neurology, Erasmus MC, Rotterdam, The Netherlands

Objective: To compare the disease course in patients with mild Guillain-Barré syndrome (GBS) who were treated with intravenous immunoglobulin (IVIg) or supportive care only.

Methods: We selected patients from the prospective observational International GBS Outcome Study (IGOS) who were able to walk independently at study entry (mild GBS), treated with one IVIg course or supportive care. The primary endpoint was the GBS disability score four weeks after study entry, assessed by multivariable ordinal regression analysis. Read More

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Guillain-Barré Syndrome after Novel Coronavirus Disease 2019.

J Emerg Med 2021 Mar 26. Epub 2021 Mar 26.

Department of Neurology, Staten Island University Hospital, Staten Island, New York; Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Manhasset, New York.

Background: Novel coronavirus disease 2019 (COVID-19) has affected more than 89 million people worldwide. As the pandemic rages on, more complications of the disease are being recognized, including stroke, cardiovascular disease, thromboembolic events, encephalopathy, seizures, and more. Peripheral nervous system involvement, particularly Guillain-Barré syndrome (GBS), is of special interest, given the increasing reports of cases related to COVID-19. Read More

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COVID-19 related multisystem inflammatory syndrome in children (MIS-C): a case series from a tertiary care pediatric hospital in Qatar.

BMC Pediatr 2021 06 8;21(1):267. Epub 2021 Jun 8.

Sidra Medicine, PO BOX 26999, Doha, Qatar.

Background: Multisystem Inflammatory Syndrome in Children (MIS-C) is a severe complication of coronavirus disease 2019 (COVID-19) in children, which is increasingly being reported worldwide. Here we report the first case series of 7 children diagnosed with MIS-C in Qatar.

Methods: Clinical features and outcomes of COVID-19 positive patients admitted to Sidra Medicine, Qatar from June to October 2020, who met the WHO case definition for MIS-C were reviewed. Read More

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[Intravenous immunoglobulin replacement therapy in 114 cases of congenital agammaglobulinemia].

Zhonghua Er Ke Za Zhi 2021 Jun;59(6):495-500

Department of Rheumatology and Immunology, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Developmental and Disorders, Chongqing Key Laboratory of Child Infection and Immunity, Chongqing 400014, China.

To analyze the clinical characteristics of congenital agammaglobulinemia and the efficacy of intravenous immunoglobulin (IVIG) replacement therapy for this disease. The basic characteristics, clinical manifestations, laboratory examinations, and outcomes of 114 patients with congenital agammaglobulinemia diagnosed in Children's Hospital of Chongqing Medical University from January 1988 to April 2020 were retrospectively analyzed. The efficacy of IVIG in improving the clinical symptoms between regular and irregular treatment groups were compared by χ test. Read More

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Enterovirus-A71 Rhombencephalitis Outbreak in Catalonia: Characteristics, Management and Outcome.

Pediatr Infect Dis J 2021 Jul;40(7):628-633

From the Pediatric Emergency Department, Department of Pediatrics, Vall d'Hebron University Hospital, Barcelona, Spain.

Background: Between April and June 2016, an outbreak of rhombencephalitis (RE) caused by enterovirus (EV) A71 was detected in Catalonia, Spain-the first documented in Western Europe. The clinical characteristics and outcome of patients with this condition differed from those reported in outbreaks occurring in Southeast Asia.

Methods: Observational, multicenter study analyzing characteristics, treatment and outcome of patients with EV-A71 rhombencephalitis diagnosed in 6 publicly funded hospitals within the Catalonian Health Institute. Read More

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Virus-triggered secondary hemophagocytic lymphohistiocytosis.

Acta Paediatr 2021 Jun 7. Epub 2021 Jun 7.

Imabari City Hospital, Imabari Ehime, 794-0026, Japan.

Primary (familial/hereditary) and secondary (non-familial/hereditary) hemophagocytic lymphohistiocytosis (HLH) are hyperinflammatory and hypercytokinemic syndromes. Secondary HLH includes infection- (e.g. Read More

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Two COVID-19-related video-accompanied cases of severe ataxia-myoclonus syndrome.

Neurol Neurochir Pol 2021 Jun 7. Epub 2021 Jun 7.

Neurology&Stroke Dpt., St. Adalbert Hospital, Gdańsk, Poland.

Aim Of Study: The pandemic state of COVID-19 has resulted in new neurological post-infection syndromes. Recently, several papers have reported ataxia-myoclonus syndrome following SARS-CoV-2 infection. The aim of this study was to present our two cases and compare them to previously reported cases. Read More

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Kawasaki Disease Complicated by Late-Onset Fatal Cerebral Infarction: A Case Report and Literature Review.

Front Pediatr 2021 19;9:598867. Epub 2021 May 19.

Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education Chengdu, Sichuan University, Chengdu, China.

Cerebral infarction is a rare neurological complication of Kawasaki disease (KD) and occurs in the acute or subacute stage. There have been no reported cases of late-onset fatal cerebral infarction presenting over 1 year after the onset of KD. A 5-month-old male patient with KD received timely intravenous immunoglobulin therapy; however, extensive coronary artery aneurysms (CAA) and coronary artery thrombosis (CAT) developed 1 month later. Read More

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Adalimumab-Induced Thrombocytopenia in a Patient With Hidradenitis Suppurativa.

Cureus 2021 Apr 30;13(4):e14769. Epub 2021 Apr 30.

Hematology and Medical Oncology, Jamaica Hospital Medical Center, Queens, USA.

Adalimumab-induced thrombocytopenia is a rarely occurring condition that may present with hemorrhagic manifestations. This report describes a case of a patient who presented with severe, symptomatic thrombocytopenia while on adalimumab for the treatment of hidradenitis suppurativa. The patient responded to treatment with steroids, intravenous immunoglobulin (IVIG), and platelet transfusion, in addition to discontinuation of adalimumab. Read More

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