23,302 results match your criteria Intravenous Immunoglobulin


Drug Reaction with Eosinophilia and Systemic Symptoms (DReSS): How Far Have We Come?

Am J Clin Dermatol 2019 Jan 17. Epub 2019 Jan 17.

Department of Dermatology, University of Toronto, Toronto, Canada.

Drug reaction with eosinophilia and systemic symptoms (DReSS), also known as drug-induced hypersensitivity syndrome (DiHS), is an uncommon severe adverse reaction to medications. It is important to recognize it as it is potentially fatal and can cause significant morbidity. From the first reports of drug reactions related to certain anticonvulsants characterized by fever, liver enzyme elevation, and skin changes, our continuously growing understanding of this entity has allowed us to describe its physiopathology and clinical features even further. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s40257-018-00416-4DOI Listing
January 2019

Probable Etoricoxib-Induced Severe Thrombocytopenia: A Case Report.

Med Princ Pract 2019 Jan 16. Epub 2019 Jan 16.

Objective: To describe a case of likely etoricoxib-induced severe thrombocytopenia.

Clinical Presentation And Intervention: A 32-year-old woman was referred to our hospital for disseminated petechial rash after seven days of therapy with etoricoxib. At admission, the patient's platelet count was 3000/mmc. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000496975DOI Listing
January 2019

Comparative Efficacy of Medical Treatments for Thyroid Eye Disease: A Network Meta-Analysis.

J Ophthalmol 2018 12;2018:7184163. Epub 2018 Dec 12.

Department of Ophthalmology, Fujian Provincial Hospital, Fuzhou, Fujian, China.

Purpose: Numerous medical strategies have been proposed for the treatment of thyroid eye disease (TED); however, the best methods for standard treatment are still a matter of controversy. The purpose of this network meta-analysis was to integrate previous evidence to create hierarchies of comparative efficacy of eleven commonly used medical treatments for TED.

Methods: A comprehensive search of electronic scientific literature databases was performed and the data from randomized controlled trials (RCTs) comparing treatment outcomes for patients with active TED were selected. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2018/7184163DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311851PMC
December 2018

Vaccine-induced immune thrombocytopaenia purpura in autologous haematopoietic stem cell transplantation.

Med J Malaysia 2018 Dec;73(6):430-432

Universiti Kebangsaan Malaysia Medical Centre, Cell Therapy Centre, Kuala Lumpur, Malaysia.

Immune Thrombocytopenia Purpura (ITP) secondary to vaccinations is rare, especially after autologous hematopoietic stem cell transplantation (HSCT). A 31-yearold female received autologous HSCT for relapsed Hodgkin Disease, with platelet engraftment at Day+14. One week after receiving second scheduled vaccinations, she developed severe thrombocytopenia (3x10/L) associated with pharyngeal hematoma. Read More

View Article

Download full-text PDF

Source
December 2018

A case report of refractory kawasaki disease.

Authors:
S H Ng S Roshan

Med J Malaysia 2018 Dec;73(6):410-412

Hospital Sultanah Bahiyah, Department of Paediatrics, Kedah, Malaysia.

Kawasaki disease is an autoimmune disease that commonly affects children below the age of 5 years. It is a vasculitic disease of unknown aetiology effecting the skin, eyes, lymph nodes and mucosal layer. Intravenous Immunoglobulin (IVIG) and aspirin therapy are the mainstay treatment however a number of cases have been shown to be refractory to this treatment. Read More

View Article

Download full-text PDF

Source
December 2018

The Effectiveness of Different Doses of Intravenous Immunoglobulin on Severe Hand, Foot and Mouth Disease: A Meta-Analysis.

Med Princ Pract 2019 Jan 15. Epub 2019 Jan 15.

Objective: To conduct a meta-analysis of evidence from randomized controlled trails (RCTs) of different doses of Intravenous Immunoglobulin (IVIG) in children with severe hand, foot and mouth disease (HFMD) to provide the scientific basis for clinical practice.

Methods: A search of PubMed-Medline, CNKI, Wanfang, and VIP database (until 30 June 2017) was performed and Software RevMan5.3 was used to evaluate the effect of different doses of IVIG on HFMD in RCTs, We used random effects models (or fixed effects models) and generic inverse variance methods to process quantitative data, followed by a leave-one-out method for sensitivity analysis. Read More

View Article

Download full-text PDF

Source
https://www.karger.com/Article/FullText/496926
Publisher Site
http://dx.doi.org/10.1159/000496926DOI Listing
January 2019
1 Read

Health-Related Quality of Life in Patients with CVID Under Different Schedules of Immunoglobulin Administration: Prospective Multicenter Study.

J Clin Immunol 2019 Jan 15. Epub 2019 Jan 15.

Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy.

Objective: We assessed the health-related quality of life (HRQoL) in CVID adults receiving different schedules of immunoglobulin replacement therapy (IgRT) by intravenous (IVIG), subcutaneous (SCIG), and facilitated (fSCIG) preparations. For these patients, IgRT schedule was chosen after a period focused on identifying the most suitable individual option.

Methods: Three hundred twenty-seven participants were enrolled in a prospective, observational, 18-month study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10875-019-0592-5DOI Listing
January 2019

Rescue therapy for acute idiopathic thrombocytopenic purpura unresponsive to conventional treatment.

BMJ Case Rep 2019 Jan 14;12(1). Epub 2019 Jan 14.

Department of Hematology-Oncology, Louisville School of Medicine, Louisville, Kentucky, USA.

A 61-year-old woman with chronic lymphocytic leukaemia, with Richter's transformation to a diffuse, large, B-cell lymphoma, treated with six cycles of rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone and in complete remission, presented to the hospital after her platelets were found to be 2×10³/µL in outpatient laboratory studies. She initially underwent a platelet transfusion without improvement. This was followed by 4 days of high-dose dexamethasone and intravenous immunoglobulin, which again yielded no meaningful effect. Read More

View Article

Download full-text PDF

Source
http://casereports.bmj.com/lookup/doi/10.1136/bcr-2018-22771
Publisher Site
http://dx.doi.org/10.1136/bcr-2018-227717DOI Listing
January 2019
1 Read

Chronic lymphocytic leukaemia masquerading as a labial lump.

BMJ Case Rep 2019 Jan 14;12(1). Epub 2019 Jan 14.

Department of Gynaecology, St Vincent's Hospital, Darlinghurst, New South Wales, Australia.

We report a case of an 82-year-old woman who presented with a 2-week history of a left labial lump. She had a history of chronic lymphocytic leukaemia (CLL) for several years and remained stable without clinical evidence of disease progression. She was observed with regular blood tests and clinical assessment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bcr-2018-227328DOI Listing
January 2019

Fulminant Guillain-Barré syndrome in a patient with systemic lupus erythematosus.

BMJ Case Rep 2019 Jan 14;12(1). Epub 2019 Jan 14.

Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Ontario, Canada.

A 45-year-old man with a history of systemic lupus erythematosus presented with progressive weakness and areflexia. Electromyogram revealed reduced motor and sensory amplitudes without demyelinating features. He was clinically diagnosed with the acute motor and sensory axonal neuropathy variant of Guillain-Barré syndrome. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bcr-2018-226634DOI Listing
January 2019

Follow-up of patients with epilepsy harboring antiglycine receptor antibodies.

Epilepsy Behav 2019 Jan 11;92:103-107. Epub 2019 Jan 11.

Department of Neuroscience, Istanbul University, Institute of Experimental Medicine, Istanbul, Turkey.

Objective: The long-term follow-up of patients with epilepsy harboring autoantibodies against the glycine receptor (also glycine receptor antibodies or GlyR-Ab) is not well-known. Our aim was to investigate the 5-year prognosis and treatment response of patients with epilepsy who were seropositive for GlyR-Ab.

Methods: Clinical features; electroencephalogram (EEG), neuroradiological, and neuropathological findings; and treatment responses of patients with epilepsy with GlyR-Ab seropositivity were investigated. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S15255050183060
Publisher Site
http://dx.doi.org/10.1016/j.yebeh.2018.09.034DOI Listing
January 2019
2 Reads

Complex regional pain syndrome - False hopes and miscommunications.

Autoimmun Rev 2019 Jan 10. Epub 2019 Jan 10.

Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis School of Medicine, United States. Electronic address:

Complex regional pain syndrome (CRPS) has been considered to be an autoimmune disease and there have been clinical trials with intravenous immunoglobulin. Often the etiology of the so-called CRPS diagnosis cannot be discerned and there are no validated instruments that provide functional metrics. The term complex regional pain syndrome (CRPS), coined in 1994 to describe patients in whom the pain is out of proportion to the injury, was actually a diagnosis proposed during the American Civil War, but was originally known as causalgia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.autrev.2018.10.003DOI Listing
January 2019

Mechanisms of action and historical facts on the use of intravenous immunoglobulins in systemic lupus erythematosus.

Autoimmun Rev 2019 Jan 11. Epub 2019 Jan 11.

GIRAT: Grupo de Investigación en Reumatología, Autoinmunidad y Medicina traslacional. Fundación Valle del Lili, Univesidad Icesi, Colombia; Laboratory of immunology, Fundación Valle del Lili, Cali, Colombia. Electronic address:

The current existing therapies for severe cases of systemic lupus erythematosus (SLE) patients are still limited. Intravenous immunoglobulin (IVIGs), which are purified from the plasma of thousands of healthy human donors, have been profiled as efficacious and life-saving options for SLE patients refractory to conventional therapy. The specific mechanism of action by which IVIGs generate immunomodulation in SLE is not currently understood. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.autrev.2018.10.002DOI Listing
January 2019

Rh (D) alloimmunization treated by double filtration plasmapheresis.

Transfus Apher Sci 2018 Dec 8. Epub 2018 Dec 8.

Canakkale 18 Mart University Hospital, Nephrology Department, Canakkale, Turkey. Electronic address:

Here in this report a 31 year old pregnant woman with positive serum antiglobulin test against anti-D antierythrocyte antibodies who was treated succesfully with double filtration plasmapheresis (DFPP) is presented. The DFPP was started in the early stage of pregnancy together with intravenous immunoglobulin therapy and the antierythrocyte antibody titer of the patient was successfully maintained in a stable level below 1:64 dilution. She delivered successfully on the 30th week of gestation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.transci.2018.12.002DOI Listing
December 2018
1 Read

Clinical manifestations, treatment outcomes, and prognostic factors of pediatric anti-NMDAR encephalitis in tertiary care hospitals: A multicenter retrospective/prospective cohort study.

Brain Dev 2019 Jan 10. Epub 2019 Jan 10.

Department of Pediatrics, King Chulalongkorn Memorial Hospital, The Thai Red Cross Society, Thailand; Division of Neurology, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. Electronic address:

Objective: Anti-NMDAR encephalitis is an acute autoimmune neurological disorder that is increasingly recognized in pediatric populations. Several studies of the disorder have been conducted worldwide but there are few publications in Thailand. Here, we describe the clinical manifestations, treatment outcomes, and prognostic factors in children with anti-NMDAR encephalitis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.braindev.2018.12.009DOI Listing
January 2019

Antibody-mediated rejection after cardiac transplant: Treatment with immunoadsorption, intravenous immunoglobulin, and anti-thymocyte globulin.

Int J Artif Organs 2019 Jan 14:391398818823763. Epub 2019 Jan 14.

1 Department of Cardiovascular Surgery, Heinrich-Heine University Hospital, Düsseldorf, Germany.

Antibody-mediated rejection of allograft is a poorly understood problem after cardiac transplantation that complicates the postoperative course and impairs the graft function and overall survival. Although plasmapheresis and intravenous immunoglobulins have been used as standard therapies for years, there is no consensus about antibody-mediated rejection therapy and most transplantation centers have their own protocols. We describe herein a successful treatment for an acute antibody-mediated rejection of cardiac allograft combining immunoadsorption, intravenous immunoglobulins, and anti-thymocyte globulin, which manifested with polymorphic ventricular tachycardia and right ventricular dysfunction. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0391398818823763DOI Listing
January 2019

Clazakizumab in late antibody-mediated rejection: study protocol of a randomized controlled pilot trial.

Trials 2019 Jan 11;20(1):37. Epub 2019 Jan 11.

Division of Nephrology and Dialysis, Department of Medicine III, Medical University of Vienna, Währinger Gürtel 18-20, A-1090, Vienna, Austria.

Background: Late antibody-mediated rejection (ABMR) triggered by donor-specific antibodies (DSA) is a cardinal cause of kidney allograft dysfunction and loss. Diagnostic criteria for this rejection type are well established, but effective treatment remains a major challenge. Recent randomized controlled trials (RCT) have failed to demonstrate the efficacy of widely used therapies, such as rituximab plus intravenous immunoglobulin or proteasome inhibition (bortezomib), reinforcing a great need for new therapeutic concepts. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13063-018-3158-6DOI Listing
January 2019

Stevens Johnson Syndrome and Toxic Epidermal Necrolysis - an Australian analysis of treatment outcomes and mortality.

J Dermatolog Treat 2019 Jan 11:1-19. Epub 2019 Jan 11.

b Department of Dermatology , Royal Adelaide Hospital , Australia.

Background: Stevens Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are rare diseases with devastating consequences on morbidity and mortality. There are currently no standardized guidelines for treatment of SJS/TEN in Australia.

Method: Retrospective chart review of all SJS/TEN cases treated at the Royal Adelaide Hospital from 2000 to 2017. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/09546634.2019.1568380DOI Listing
January 2019
1 Read

Incidence and Outcome of Severe and Nonsevere Thrombocytopenia Associated With Zika Virus Infection-Puerto Rico, 2016.

Open Forum Infect Dis 2019 Jan 3;6(1):ofy325. Epub 2018 Dec 3.

United States Public Health Service, Silver Springs, Maryland.

Background: Zika virus (ZIKV) infection has been associated with severe thrombocytopenia. We describe the incidence, clinical manifestations, and outcomes of patients with ZIKV infection and thrombocytopenia.

Methods: We reviewed medical records of patients with ZIKV infection and thrombocytopenia (platelet count <100 ×10 cells/L) in Puerto Rico during 2016. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ofid/ofy325DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324556PMC
January 2019

Anti-NMDA receptor encephalitis.

QJM 2019 Jan 10. Epub 2019 Jan 10.

Professor, Department of Medicine, Government Medical College, Kozhikode, Kerala, India.

Anti-NMDA receptor encephalitis is a rare cause of acute encephalitis caused by autoantibodies against N-methyl-D-aspartate (NMDA) receptor in the brain. The disease commonly affects young females and often presents as acute psychoses and movement disorders. We here report a case of a young female who presented with acute psychosis and was initially managed with anti-psychotics. Read More

View Article

Download full-text PDF

Source
https://academic.oup.com/qjmed/advance-article/doi/10.1093/q
Publisher Site
http://dx.doi.org/10.1093/qjmed/hcz005DOI Listing
January 2019
1 Read

Oral Administration of Human Polyvalent IgG by Mouthwash as an Adjunctive Treatment of Chronic Oral Candidiasis.

Front Immunol 2018 21;9:2956. Epub 2018 Dec 21.

Departamento de Investigación en Microbiología, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City, Mexico.

is a commensal fungus that can cause disease ranging in severity from moderate to severe mucosal infections to more serious life-threating disseminated infections in severely immunocompromised hosts. Chronic mucocutaneous candidiasis (CMC) occurs in patients with mutations in genes affecting IL-17-mediated immunity, such as , and , or gain of function (GOF) mutations in . New strategies for the treatment of candidiasis are needed because of the increased burden of infections and the emergence of drug-resistant strains. Read More

View Article

Download full-text PDF

Source
https://www.frontiersin.org/article/10.3389/fimmu.2018.02956
Publisher Site
http://dx.doi.org/10.3389/fimmu.2018.02956DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309162PMC
December 2018
2 Reads

[Refractory primary immune thrombocytopenia in pregnancy requiring splenectomy and repeated intravenous immunoglobulin therapy].

Rinsho Ketsueki 2018 ;59(12):2574-2577

Third Department of Internal Medicine, Yamaguchi University School of Medicine.

A 30-year-old primigravid woman without a history of thrombocytopenia was referred to our hospital because of severe thrombocytopenia (<1,000 thrombocytes/µl) at 16 weeks of gestation and diagnosed with idiopathic thrombocytopenic purpura (ITP). There was no improvement in the platelet count after treatment with 0.5-1. Read More

View Article

Download full-text PDF

Source
https://www.jstage.jst.go.jp/article/rinketsu/59/12/59_2574/
Publisher Site
http://dx.doi.org/10.11406/rinketsu.59.2574DOI Listing
January 2018
1 Read

In-hospital and post-discharge outcomes of pediatric acute myocarditis underwent after high-dose steroid or intravenous immunoglobulin therapy.

BMC Cardiovasc Disord 2019 Jan 9;19(1):10. Epub 2019 Jan 9.

Department of Cardiology, Chiayi Chang Gung Memorial Hospital, No. 6, Sec. West, Chai-Pu Road, Pu-TZ City, Chai Yi Hsien, Taiwan.

Background: High-dose steroids and intravenous immunoglobulin (IVIG) are controversial treatments for pediatric patients with acute myocarditis. This study aimed to investigate their efficacies in the Taiwanese pediatric population.

Methods: This study evaluated 5563 acute myocarditis patients from the Taiwan's National Health Insurance Research Database and identified 1542 pediatric patients hospitalized for acute myocarditis between January 1, 2001 and December 31, 2011. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12872-018-0981-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325679PMC
January 2019

Successful Outcome of Hyperhemolysis in Sickle Cell Disease following Multiple Lines of Treatment: The Role of Complement Inhibition.

Hemoglobin 2019 Jan 9:1-3. Epub 2019 Jan 9.

a Adult Thalassaemia Unit, 2nd Department of Internal Medicine , Aristotle University of Thessaloniki, Hippokration General Hospital of Thessaloniki , Thessaloniki , Greece.

Delayed hemolytic transfusion reaction (DHTR) is a life-threatening complication in patients with sickle cell disease, characterized by difficulties in diagnosis and management. Certain reports have suggested successful salvage treatment with the terminal complement inhibitor, eculizumab. We here report evidence of complement activation and successful complement inhibition with one dose of eculizumab in an adult sickle cell disease patient presenting DHTR with hyperhemolysis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/03630269.2018.1540353DOI Listing
January 2019

Caplacizumab Treatment for Acquired Thrombotic Thrombocytopenic Purpura.

N Engl J Med 2019 Jan 9. Epub 2019 Jan 9.

From the Department of Haematology, University College London Hospitals, Cardiometabolic Program, National Institute for Health Research UCLH-UCL Biomedical Research Center, London (M.S.); the Division of Hematology, Department of Internal Medicine, Ohio State University, Columbus (S.R.C.); Fondazione Istituti di Ricovero e Cura a Carattere Scientifico Ca' Granda Ospedale Maggiore Policlinico, Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, and the Department of Pathophysiology and Transplantation, University of Milan, Milan (F.P.); the Department of Hematology, Saint-Antoine University Hospital, Paris (P.C.); the Department of Medicine 1, Division of Hematology and Hemostasis, Medical University of Vienna, Vienna (P.K.); the Department of Hematology and Central Hematology Laboratory, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland (J.A.K.H.); the Division of Hematology, Duke University School of Medicine, Durham, NC (A.M.); the Hematology Department, Universidad Católica de Valencia Hospital Dr. Peset, Valencia, Spain (J.R.); the Departments of Medicine and Laboratory Medicine, St. Michael's Hospital and University of Toronto, Toronto (K.P.); and Clinical Development, Ablynx, Zwijnaarde, Belgium (F.C., D.B., H.D.W., R.K.Z.).

Background: In acquired thrombotic thrombocytopenic purpura (TTP), an immune-mediated deficiency of the von Willebrand factor-cleaving protease ADAMTS13 allows unrestrained adhesion of von Willebrand factor multimers to platelets and microthrombosis, which result in thrombocytopenia, hemolytic anemia, and tissue ischemia. Caplacizumab, an anti-von Willebrand factor humanized, bivalent variable-domain-only immunoglobulin fragment, inhibits interaction between von Willebrand factor multimers and platelets.

Methods: In this double-blind, controlled trial, we randomly assigned 145 patients with TTP to receive caplacizumab (10-mg intravenous loading bolus, followed by 10 mg daily subcutaneously) or placebo during plasma exchange and for 30 days thereafter. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1056/NEJMoa1806311DOI Listing
January 2019

Intravenous immunoglobulins in patients with clinically suspected chronic immune-mediated neuropathy.

J Neurol Sci 2018 Dec 31;397:141-145. Epub 2018 Dec 31.

Department of Neurology and Neurophysiology, Amsterdam university medical centers, University of Amsterdam, Amsterdam, The Netherlands.

Intravenous immunoglobulins (IVIg) are an efficacious treatment for chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) and multifocal motor neuropathy (MMN). IVIg is considered in patients who have a high suspicion of an inflammatory neuropathy, but do not meet diagnostic criteria. The objective of this retrospective study was to assess which diagnostic results led to the decision to administer IVIg and to determine the rate of improvement. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jns.2018.12.036DOI Listing
December 2018

Predicting Factors for the Pattern of Intravenous Immunoglobulin Utilization in a Middle Eastern University Hospital.

J Res Pharm Pract 2018 Oct-Dec;7(4):188-194

Isfahan Clinical Toxicology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.

Objective: The dramatic increase in the consumption of intravenous immunoglobulin (IVIG) products in nonapproved indications, its high cost, and the severe shortage has developed the concerns of its irrational utilization, especially in the Middle East countries. Therefore, this clinical study attempts to describe the pattern of IVIG administration in one of the largest hospitals in Iran and find the variables associated with inappropriate IVIG utilization.

Methods: This cross-sectional medication utilization study was conducted in one of the largest referral hospitals in Iran. Read More

View Article

Download full-text PDF

Source
http://www.jrpp.net/text.asp?2018/7/4/188/246991
Publisher Site
http://dx.doi.org/10.4103/jrpp.JRPP_18_73DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298141PMC
January 2019
1 Read

Anti-GAD Antibody-associated Syndrome Presenting with Limb Myoclonus.

Tremor Other Hyperkinet Mov (N Y) 2018 1;8:590. Epub 2018 Nov 1.

Department of Neurology, Instituto Hospital de Base do Distrito Federal, Brasília, BR.

Background: The clinical spectrum of anti-glutamic acid decarboxylase (GAD) antibody-associated neurologic syndromes is expanding, with focal, generalized, and atypical forms.

Case Report: We describe a 59-year-old female showing continuous right lower limb myoclonus and mild encephalopathy. These symptoms started 2 weeks prior to evaluation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7916/D8NK4XVPDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315060PMC
November 2018

Acute disseminated encephalomyelitis in an older adult following prostate resection.

eNeurologicalSci 2019 Mar 22;14:40-42. Epub 2018 Nov 22.

The London Clinic, London, UK.

Acute disseminated encephalomyelitis (ADEM) is an uncommon, autoimmune, demyelinating disorder of of the central nervous system. It is rare in adults beyond 65 years. Here, we describe a novel presentation following urological surgery. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ensci.2018.11.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304343PMC

Disseminated adenovirus infection in a 10-year-old renal allograft recipient.

Kidney Res Clin Pract 2018 Dec 31;37(4):414-417. Epub 2018 Dec 31.

Division of Nephrology, Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea.

Disseminated adenovirus infection can result in high mortality and morbidity in immunocompromised patients. Here, we report the case of a 10-year-old renal allograft recipient who presented with hematuria and dysuria. Adenovirus was isolated from his urine. Read More

View Article

Download full-text PDF

Source
http://www.krcp-ksn.org/journal/view.html?doi=10.23876/j.krc
Publisher Site
http://dx.doi.org/10.23876/j.krcp.18.0048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312782PMC
December 2018
3 Reads

Interleukin-6 is prone to be a candidate biomarker for predicting incomplete and IVIG nonresponsive Kawasaki disease rather than coronary artery aneurysm.

Clin Exp Med 2019 Jan 8. Epub 2019 Jan 8.

Department of Pediatrics, the First Affiliated Hospital of Anhui Medical University, No. 218 Ji-Xi Road, Hefei, 230022, People's Republic of China.

Kawasaki disease (KD) is an acute, systemic vasculitis and occurs mainly in childhood. Interleukin-6 (IL-6) is a pleiotropic cytokine synthesized predominantly by neutrophils and monocytes/macrophages and plays an important role in systemic inflammatory disease. However, a little information is currently available on the relationship of serum IL-6 with conventional inflammatory mediators, clinical classification, IVIG response and coronary artery aneurysm (CAA). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10238-018-00544-5DOI Listing
January 2019

Incidence and timing of recurrence of optic neuritis.

Graefes Arch Clin Exp Ophthalmol 2019 Jan 5. Epub 2019 Jan 5.

Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.

Purpose: To describe the incidence and timing of recurrence in patients with optic neuritis (ON).

Methods: Medical documents of adult patients with ON were retrospectively reviewed. The incidence and timing of recurrence of an ON episode were analyzed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00417-018-04217-7DOI Listing
January 2019

Kawasaki disease shock syndrome: clinical characteristics and possible use of IL-6, IL-10 and IFN-γ as biomarkers for early recognition.

Pediatr Rheumatol Online J 2019 Jan 5;17(1). Epub 2019 Jan 5.

Department of Rheumatology Immunology and Allergy, Children's Hospital, Zhejiang University School of Medicine, No.57, Zhugan Lane, Yan-an Road, Hangzhou, 310003, China.

Background: As an acute febrile and inflammatory disease, Kawasaki disease (KD) could develop Kawasaki disease shock syndrome (KDSS) sometimes. However its pathogenesis was still not well known. This study was to learn more about the clinical features and evaluate the role of cytokines in the pathogenesis of KDSS. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12969-018-0303-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321686PMC
January 2019

Adverse Reactions to Intravenous Immunoglobulins - Our Experience.

Open Access Maced J Med Sci 2018 Dec 17;6(12):2359-2362. Epub 2018 Dec 17.

University Pediatric Hospital, Ss Cyril and Methodius University of Skopje, Skopje, Republic Macedonia.

Background: Adverse reactions to intravenous immunoglobulins (IVIG) are divided by organ system involved, or by timing of onset-immediate which occur during infusion usually rate-related, true IgE-mediated anaphylaxis and delayed reaction which occur hours to days after the infusion.

Aim: To describe the adverse events of patients given IVIG infusions.

Methods: Total number of patients receiving IVIG was 41 with 25 males (60. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3889/oamjms.2018.513DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311486PMC
December 2018
3 Reads

[Chlorhexidine anaphylaxis in a perioperative context: diagnosis and management].

Rev Alerg Mex 2018 Oct-Dec;65(4):431-436

Universidad de Antioquia, Grupo de Alergología Clínica y Experimental, Medellín, Colombia.

Background: During surgery, the patient is exposed to multiple medications and molecules that can be associated with the development hypersensitivity, which makes it difficult to detect the causative agent of a perioperative reaction and makes it necessary to perform allergy tests.

Case Report: 53-year-old man who after a right knee arthroscopy was administered intravenous ketorolac; at 12 minutes, a pruriginous rash appeared on the chest, abdomen and limbs; infusion of the drug was immediately stopped and 100 mg intravenous hydrocortisone were administered. At 15 minutes, the patient experienced bilateral angioedema of the eyelids and a sensation of breathlessness, and oxygen was therefore administered, as well as 2 mg intravenous clemastine, 5 mg intravenous ranitidine and 20 µg subcutaneous adrenaline. Read More

View Article

Download full-text PDF

Source
http://revistaalergia.mx/ojs/index.php/ram/article/view/347
Publisher Site
http://dx.doi.org/10.29262/ram.v65i4.347DOI Listing
January 2019
2 Reads

Hemophagocytic Lymphohistiocytosis Associated with Infection in a Child: A Case Report with Review of Literature.

Case Rep Pediatr 2018 22;2018:6236270. Epub 2018 Nov 22.

Pediatic Hematology, Pablo Tobon Uribe Hospital, Medellin, Colombia.

We present the case of an 8-year-old girl with hemophagocytic lymphohistiocytosis secondary to a infection. She received antibiotic treatment and intravenous immunoglobulin with complete resolution of the symptoms. We present a review of previously reported pediatric cases and propose a gradual approach to treatment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2018/6236270DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282142PMC
November 2018
1 Read

Coronary artery status of patients with transient fever 24-36 h after first IVIG infusion did not differ from that seen in responsive patients.

Pediatr Rheumatol Online J 2018 Dec 29;16(1):83. Epub 2018 Dec 29.

Department of Pediatrics, University of Ulsan College of Medicine, Seoul, South Korea.

Background: Current management guidelines for patients with Kawasaki disease (KD) differ in their recommendations for fever observation times when determining resistance to initial intravenous immunoglobulin (IVIG). This retrospective study assessed coronary artery status in patients with transient fever 24-36 h after the completion of a first IVIG infusion.

Methods: Children with KD treated with IVIG between January 2006 and February 2017 were included. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12969-018-0301-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311065PMC
December 2018
1 Read

Acute disseminated encephalomyelitis: complication of a vaccine preventable disease.

BMJ Case Rep 2018 Dec 27;11(1). Epub 2018 Dec 27.

Department of Virology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Acute disseminated encephalomyelitis (ADEM) is a rare inflammatory-demyelinating disease of central nervous system. Several viral infections and vaccines act as precipitating factor for ADEM. We report an 8-year-old girl presenting with acute-onset flaccid paraparesis and bilateral painless vision loss. Read More

View Article

Download full-text PDF

Source
http://casereports.bmj.com/lookup/doi/10.1136/bcr-2018-22571
Publisher Site
http://dx.doi.org/10.1136/bcr-2018-225710DOI Listing
December 2018
5 Reads

Biologics and immunoglobulins in the treatment of pyoderma gangrenosum - analysis of 52 patients.

J Dtsch Dermatol Ges 2019 Jan 28;17(1):32-41. Epub 2018 Dec 28.

Center of Competence for Health Care Research in Dermatology (CVderm), Institute for Health Care Research in Dermatology and Nursing (IVDP), Hamburg-Eppendorf University Medical Center, Hamburg, Germany.

Background And Objectives: Corticosteroids and cyclosporine A are frequently ineffective as first-line therapies in the treatment of pyoderma gangrenosum (PG) and associated with a number of adverse effects. The objective of the present study was to analyze the effectiveness and safety of biologics and intravenous immunoglobulins (IVIGs).

Patients And Methods: Retrospective, dual-center cohort study analyzing the treatment outcome in patients with PG who received biologics and IVIGs. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/ddg.13741
Publisher Site
http://dx.doi.org/10.1111/ddg.13741DOI Listing
January 2019
6 Reads

Fatal, paraparetic acute motor axonal neuropathy, early complicating chemotherapy with nab-paclitaxel.

Anticancer Drugs 2018 Dec 26. Epub 2018 Dec 26.

Departments of Neurology.

So far, very few cases describing an interrelation between chemotherapy and Guillain-Barré syndrome have been published. We describe the first case of a paraparetic, pure acute motor axonal neuropathy variant of Guillain-Barré syndrome, early complicating protein-bound paclitaxel (nab-paclitaxel/abraxane) chemotherapy (first and sole session at a 350 mg dose) in a female patient with metastatic breast cancer. Although our patient was treated with the standard regimen of intravenous immunoglobulin for 5 days, she showed no evidence of motor improvement and died 1 month after the onset of the neurological deficit. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/CAD.0000000000000739DOI Listing
December 2018
1 Read

Phototherapy is associated with the decrease in serum globulin levels in neonatal hyperbilirubinemia.

Biomed Rep 2019 Jan 9;10(1):63-69. Epub 2018 Nov 9.

Department of Pediatrics and Neonatology, Children's Digital Health and Data Center, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430071, P.R. China.

Previous studies have indicated that phototherapy may be associated with childhood immune disorders in later life. The present study aimed to assess the effects of phototherapy as a risk factor in the decrease in serum globulin (GLB) levels during neonatal hyperbilirubinemia. A total of 430 full-term infants aged between 1 and 28 days, diagnosed with neonatal hyperbilirubinemia, were enrolled in the present study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3892/br.2018.1166DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299213PMC
January 2019

Resistant Cytomegalovirus Infection in Solid-organ Transplantation: Single-center Experience, Literature Review of Risk Factors, and Proposed Preventive Strategies.

Transplant Proc 2018 Dec 26;50(10):3756-3762. Epub 2018 Oct 26.

Division of Infectious Diseases, Department of Medicine, University of Arizona, Tucson, Arizona.

Background: Cytomegalovirus (CMV) infection causes morbidity and mortality in solid-organ transplant recipients. Drug-resistant CMV is an emerging problem with poor survival outcomes and limited therapeutic options. In this study we comprehensively address the issue of drug resistance in CMV when compared with standard therapies, such as ganciclovir (GCV) and foscarnet. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.transproceed.2018.02.091DOI Listing
December 2018
1 Read

Atraumatic splenic rupture following IVIg for parvovirus B19 pure red cell aplasia post renal transplant.

Transpl Infect Dis 2018 Dec 26:e13045. Epub 2018 Dec 26.

Department of Anatomical Pathology, Alfred Health, Melbourne, Victoria, Australia.

Parvovirus B19 (PB19) associated pure red cell aplasia (PRCA) is an uncommon but well described complication of immunosuppression post solid organ transplantation. We report a unique case of a renal transplant patient with PB19 associated PRCA who developed a spontaneous splenic rupture after receiving IVIg for persistent anemia. He subsequently required splenectomy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/tid.13045DOI Listing
December 2018
1 Read

Procalcitonin levels predicting the infliximab response of immunoglobulin resistant Kawasaki disease.

Cytokine 2018 Dec 21;114:26-31. Epub 2018 Dec 21.

Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Objective: To search the predictive factors of infliximab resistance in intravenous immunoglobulin (IVIG)-resistant Kawasaki disease (KD) patients.

Study Design: Twenty-seven patients with KD who received infliximab after 4-5 g/kg of IVIG therapy from 2013 to 2015 were consecutively recruited in this study. They were divided into two groups: patients who responded to infliximab (infliximab-responsive group, n = 15) and patients who required additional therapy for the disease control (infliximab-resistant group, n = 12). Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S10434666183046
Publisher Site
http://dx.doi.org/10.1016/j.cyto.2018.11.025DOI Listing
December 2018
5 Reads

Clinical characteristics and effective treatments of scrub typhus-associated hemophagocytic lymphohistiocytosis in children.

J Adv Res 2019 Jan 18;15:111-116. Epub 2018 Jul 18.

Department of Pediatrics, First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.

Hemophagocytic lymphohistiocytosis (HLH) is an uncommon and life-threatening disorder that may rarely complicate the clinical course of Orientia tsutsugamushi disease (scrub typhus). Here, we describe the clinical features, laboratory parameters, management, and outcome of 16 children with scrub typhus-associated HLH. All patients satisfied the HLH-2004 diagnostic criteria. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jare.2018.05.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300568PMC
January 2019
1 Read

Intravenous immunoglobulin use in children with ITP does not affect development of chronic disease.

J Pediatr 2019 Jan;204:320-323

The Children's Hospital of Philadelphia Philadelphia, Pennsylvania.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpeds.2018.10.076DOI Listing
January 2019

Dynamic evaluation of hemostasis in the acute phase of Kawasaki disease using comprehensive coagulation functional assays.

Thromb Res 2018 Dec 13;174:76-83. Epub 2018 Dec 13.

Department of Pediatrics, Nara Medical University, Kashihara, Nara, Japan.

Introduction: Kawasaki disease (KD) is a systemic vasculitis involving coronary arteries, sometimes resulting in aneurysms and myocardial infarction. Hyper-coagulability in the acute-phase of KD is indicated in some circumstances based on changes of individual clotting factors. Comprehensive coagulation assays, clot waveform analysis (CWA) and thrombin/plasmin generation assay (T/P-GA), have been developed to assess physiological hemostasis, but these techniques have not been applied in KD. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00493848183065
Publisher Site
http://dx.doi.org/10.1016/j.thromres.2018.12.016DOI Listing
December 2018
5 Reads

Therapeutic Plasma Exchange in Pediatric Renal Transplantation Experience of One Decade and 389 Sessions.

Transplant Proc 2018 Dec 10;50(10):3483-3486. Epub 2018 Jul 10.

The Children's Memorial Health Institute, Warsaw, Poland. Electronic address:

Objective: There are no specific recommendations for therapeutic plasma exchange (TPE) in children after renal transplantation. The purpose of this study was to report the experience with TPE in a pediatric transplant setting.

Materials And Methods: 59 patients (mean age 12. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00411345183094
Publisher Site
http://dx.doi.org/10.1016/j.transproceed.2018.07.015DOI Listing
December 2018
6 Reads

Thymectomy may not be associated with clinical improvement in MuSK myasthenia gravis.

Muscle Nerve 2018 Dec 21. Epub 2018 Dec 21.

Larner College of Medicine, University of Vermont, 1 South Prospect Street, Burlington, Vermont 05401, USA.

Introduction: A randomized trial demonstrated benefit from thymectomy in nonthymomatous acetylcholine receptor (AChR)-antibody positive myasthenia gravis (MG). Uncontrolled observational and histologic studies suggest thymectomy may not be efficacious in anti-muscle-specific kinase (MuSK)-MG.

Methods: The therapeutic impact of thymectomy was evaluated from data collected for a multicenter, retrospective blinded review of rituximab in MuSK-MG. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/mus.26404DOI Listing
December 2018

Atypical Cutaneous Mucinosis Treated with Intravenous Immunoglobulin and Corticosteroid.

Skinmed 2018 21;16(6):428-431. Epub 2018 Dec 21.

Skin Research Center, Shahid Beheshti university of medical sciences, Tehran, Iran and the Department of Pathology, Loghman Hospital;

FA 25-year-old man presented with a 12-month history of progressive skin lesions involving the face, upper areas of the trunk, arms, and natal cleft. There was moderate pruritus, disfiguring lesions of the face, and mild arthralgia. No therapy had been applied before the referral to our clinic. Read More

View Article

Download full-text PDF

Source
December 2018
1 Read