2,451 results match your criteria Intramedullary Spinal Cord Tumors


Intramedullary tumours and tumour mimics.

Clin Radiol 2020 Jun 23. Epub 2020 Jun 23.

University of Iowa Hospital and Clinics, Department of Radiology, Iowa city, IOWA, USA.

Spinal cord lesions are traditionally classified as either extradural or intradural extramedullary or of intramedullary origin. Intramedullary spinal cord tumours are histopathologically similar to cranial tumours with a diverse range of pathologies. Astrocytomas and ependymomas account for approximately 80% of all intramedullary tumours, with other primary and secondary lesions accounting for the remaining 20%. Read More

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http://dx.doi.org/10.1016/j.crad.2020.05.010DOI Listing

Stereotactic Radiation for Treating Primary and Metastatic Neoplasms of the Spinal Cord.

Front Oncol 2020 9;10:907. Epub 2020 Jun 9.

Departments of Radiation Oncology, NYU Grossman School of Medicine, New York, NY, United States.

Stereotactic radiation treatment can be used to treat spinal cord neoplasms in patients with either unresectable lesions or residual disease after surgical resection. While treatment guidelines have been suggested for epidural lesions, the utility of stereotactic radiation for intradural and intramedullary malignancies is still debated. Prior reports have suggested that stereotactic radiation approaches can be used for effective tumor control and symptom management. Read More

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http://dx.doi.org/10.3389/fonc.2020.00907DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7295942PMC

Incidence and predictors of kyphotic deformity following resection of cervical intradural tumors in adults: a population-based cohort study.

Acta Neurochir (Wien) 2020 Jun 16. Epub 2020 Jun 16.

Department of Neurosurgery, Karolinska University Hospital, Elite Hotel Carolina, 4th floor, 171 76, Stockholm, Sweden.

Background: The first line of treatment for most cervical intradural tumors is surgical resection through laminotomy or laminectomy. This may cause a loss of posterior pulling force leading to kyphosis, which is associated with decreased functional outcome. However, the incidence and predictors of kyphosis in these patients are poorly understood. Read More

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http://dx.doi.org/10.1007/s00701-020-04416-4DOI Listing

Intramedullary Masses of the Spinal Cord: Radiologic-Pathologic Correlation.

Radiographics 2020 Jul-Aug;40(4):1125-1145. Epub 2020 Jun 12.

From the Department of Radiology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Rd, Bethesda, MD 20814 (R.Y.S.); and Department of Radiology, Mayo Clinic, Rochester, Minn (K.K.K.).

Spinal cord tumors are a challenge for patients and neurosurgeons because of the high risk of neurologic deficits from the disease process and surgical interventions. Spinal cord tumors are uncommon, and approximately 2%-3% of primary intra-axial tumors of the central nervous system occur in the spinal cord. Primary intra-axial tumors are usually derived from neuroepithelial tissue, especially glial cells. Read More

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http://dx.doi.org/10.1148/rg.2020190196DOI Listing

A Pain in the Neck - A Case of Intramedullary Spinal Ependymoma.

Cureus 2020 May 5;12(5):e7981. Epub 2020 May 5.

Nephrology, Augusta University Medical Center, Medical College of Georgia, Augusta, USA.

Spinal cord tumors are sporadic and account for around 2%-4% of central nervous system neoplasms. Ependymoma is one of the most common spinal cord neoplasms and can present with different neurological signs and symptoms. They commonly present with neck or back pain and associated neurological involvement, with sensory symptoms usually antedating the motor symptoms. Read More

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http://dx.doi.org/10.7759/cureus.7981DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7273354PMC

Intramedullary spinal cord tumours - a single Centre, 10-year review of clinical and pathological outcomes.

Br J Neurosurg 2020 May 22:1-4. Epub 2020 May 22.

Department of Neurosurgery, Leeds General Infirmary, Leeds, UK.

Intramedullary spinal cord tumours are relatively rare tumours of the central nervous system. Surgical outcomes are affected by many variables, including pre-operative neurological function, tumour histology and extent of resection. Emphasis remains on surgical treatment due to limited adjunctive therapeutic options and poor drug penetration. Read More

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http://dx.doi.org/10.1080/02688697.2020.1765973DOI Listing

An institutional review of 10 cases of spinal hemangiopericytoma/solitary fibrous tumor.

Neurol India 2020 Mar-Apr;68(2):448-453

Department of Neurosurgery, All India Institute of Medical Sciences, New Delhi, India.

Background: Spinal hemangiopericytoma is very rare tumors with only a few case reports and one case series. We have treated ten patients between 2004 and 2017 and, thus, present a retrospective review of our patients with a focus on clinical presentation, radiological features, management, pathology, and outcome.

Materials And Methods: Histopathological data were reviewed in all the cases and clinical and follow-up details were collected from data available in our department. Read More

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http://dx.doi.org/10.4103/0028-3886.284374DOI Listing

Intramedullary cervical spinal cord teratoma.

Medicine (Baltimore) 2020 May;99(18):e20107

Department of Orthopedics, The First People's Hospital of Yibin, Yibin City.

Background: Intramedullary cervical spinal cord teratomas (ICTs) are extremely rare, and diagnosis and treatment are challenging. We conducted a systematic review of the literature on the diagnosis and treatment of ICT.

Method: The presentation, imaging manifestations, diagnosis, management, surgery findings, prognosis and histology were reviewed following Preferred Reporting Items for Systematic Reviews and Meta Analyses guidelines. Read More

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http://dx.doi.org/10.1097/MD.0000000000020107DOI Listing

Unexpected discovery of a diffuse astrocytoma of the conus medullaris in an elderly NF1 patient.

Radiol Case Rep 2020 Jun 18;15(6):784-788. Epub 2020 Apr 18.

Department of Radiology, Toho University Sakura Medical Center.

Neurofibromatosis type 1 (NF1) is one of the most common genetic neurocutaneous disorders, and it is well known to be associated with peripheral or central nervous system malignancies. The most common malignant tumors are malignant peripheral nerve sheath tumors (MPNSTs); MPNSTs are the most common cause of death in patients with NF1. Central nervous system malignancies rarely occur. Read More

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http://dx.doi.org/10.1016/j.radcr.2020.02.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7167499PMC

Spontaneous Regression of a Symptomatic Intramedullary Spinal Cord Lesion.

Cureus 2020 Mar 14;12(3):e7271. Epub 2020 Mar 14.

Neurosurgery, Mayo Clinic, Rochester, USA.

Intramedullary spinal cord tumors and cavernous malformations are rare lesions that can lead to progressive neurologic deficits, impaired quality of life, and even death. Early diagnosis and surgical resection of spinal cord tumors and cavernous malformations are often quoted as essential to optimizing a patient's functional outcome. Unfortunately, these are high-risk operations, with many patients having worse neurological deficits after surgery - sometimes permanent. Read More

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http://dx.doi.org/10.7759/cureus.7271DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7153818PMC

Atypical presentation of spinal intramedullary astrocytoma in a patient presenting with isolated signs of intracranial hypertension.

Spinal Cord Ser Cases 2020 Apr 9;6(1):20. Epub 2020 Apr 9.

Department of Neurological Surgery, Thomas Jefferson University Hospital, 900 Walnut Street, Philadelphia, PA, 19107, USA.

Introduction: Intramedullary spinal tumors are rare entities that typically present with signs of spinal cord dysfunction including myelopathy, weakness, hypoesthesia, or bladder dysfunction. However, they can present in more insidious ways without signs of spinal cord dysfunction, as we will discuss in this case. Our patient presented with isolated signs of intracranial hypertension including headache and progressive vision loss. Read More

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http://dx.doi.org/10.1038/s41394-020-0268-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7145812PMC

Ten-Segment Intramedullary Ependymoma and Whole Spinal Syringomyelia.

World Neurosurg 2020 Apr 3;139:20-22. Epub 2020 Apr 3.

Department of Neurosurgery, Fudan University Huashan Hospital, Shanghai, China. Electronic address:

Background: Ten-segment intramedullary tumors are rare lesions in adults.

Case Description: In this report, we describe the case of a 30-year-old woman who presented with a 2-year history of right lower limb numbness. Spinal magnetic resonance imaging showed an expansive 10-segment intramedullary lesion and syringomyelia. Read More

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http://dx.doi.org/10.1016/j.wneu.2020.03.149DOI Listing

Surgical Management of Intramedullary Spinal Cord Tumors.

Neurosurg Clin N Am 2020 Apr 31;31(2):237-249. Epub 2020 Jan 31.

Department of Neurological Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA; Department of Neurological Surgery, Weill Cornell Medical College, 525 E. 68th St, New York, NY 10065, USA.

Intramedullary spinal cord tumors (IMSCT) comprise a rare subset of CNS tumors that have distinct management strategies based on histopathology. These tumors often present challenges in regards to optimal timing for surgery, invasiveness, and recurrence. Advances in microsurgical techniques and technological adjuncts have improved extent of resection and outcomes with IMSCT. Read More

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http://dx.doi.org/10.1016/j.nec.2019.12.004DOI Listing

Intracranial Metastases Originating From Pediatric Primary Spinal Cord Glioblastoma Multiforme: A Case Report and Literature Review.

Front Oncol 2020 11;10:99. Epub 2020 Feb 11.

Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Primary spinal cord glioblastoma multiforme (scGBM) is an uncommon entity in pediatrics, and intracranial metastasis originating in spinal cord gliomas is very rare. A 7-year-old female presented with weakness in the limbs, paralysis of the lower limbs and incontinence. The initial MRI of the spinal cord revealed expansion and abnormal signals from T2 to T5. Read More

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http://dx.doi.org/10.3389/fonc.2020.00099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7026187PMC
February 2020

Intraoperative Ultrasound and Contrast-Enhanced Ultrasound in Surgical Treatment of Intramedullary Spinal Tumors.

World Neurosurg 2020 May 17;137:e570-e576. Epub 2020 Feb 17.

Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Fengtai District, Beijing, China; China National Clinical Research Center for Neurological Diseases (NCRC-ND), Fengtai District, Beijing, China. Electronic address:

Background: Surgical resection of intramedullary tumors remains technically challenging. The role of intraoperative ultrasound and contrast-enhanced ultrasound (CEUS) in these surgeries has not yet been well defined. This study was aimed to evaluate the potential of intraoperative ultrasonography, especially CEUS, in visualizing intramedullary spinal cord tumors, and to assess the values for improving surgical outcomes. Read More

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http://dx.doi.org/10.1016/j.wneu.2020.02.059DOI Listing

[Intraoperative video-angiography in surgery for spinal intramedullary cavernous malformations: first experience of its application at the Burdenko Neurosurgical Center].

Zh Vopr Neirokhir Im N N Burdenko 2019 ;83(6):58-63

Burdenko Neurosurgical Center, Moscow, Russia.

Spinal intramedullary cavernous malformations are a rare vascular pathology of the central nervous system. They account for 3-5% of spinal cord diseases. The clinical picture in patients with cavernous malformations varies from an asymptomatic course to gross neurological deficit in the case of bleeding from a malformation. Read More

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http://dx.doi.org/10.17116/neiro20198306158DOI Listing

Spinal Cord Tumor Microenvironment.

Adv Exp Med Biol 2020 ;1226:97-109

Department of Neurosurgery, University Hospital Essen, Essen, Germany.

Intramedullary spinal cord tumors (IMSCT) are rare entities for which there currently exist no standardized treatment paradigms. Consequently, patients usually receive treatment modalities that were established for intracerebral tumors; these approaches, however, typically result in functional impairment, recurrent tumor growth, and short overall survival. There is a distinct lack of promising research efforts in this field, which raises questions about whether spinal cord tumor microenvironment (TME) might promote the development, progression, and treatment resistance of IMSCT. Read More

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http://dx.doi.org/10.1007/978-3-030-36214-0_8DOI Listing
February 2020

Contemporary management of pediatric spinal tumors: a single institute's experience in Taiwan in the modern era.

J Neurooncol 2020 Feb 4;146(3):501-511. Epub 2020 Feb 4.

Division of Neurosurgery, Department of Surgery, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei City, Taiwan.

Introduction: Pediatric spinal tumors are unique pathologies treated by pediatric neurosurgeons. Special attention is required for the preservation of neural function and bony alignment. We reported our experience in the management of these challenging lesions. Read More

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http://dx.doi.org/10.1007/s11060-020-03400-3DOI Listing
February 2020

Perineural invasion in intramedullary spinal cord metastasis.

Ann R Coll Surg Engl 2020 May 31;102(5):e94-e96. Epub 2020 Jan 31.

University Hospitals of Derby and Burton NHS Foundation Trust, UK.

A woman in her late sixties was referred to the orthopaedic clinic with progressive lower limb weakness and gait disturbance. She was known to have breast cancer with pre-existing infiltrative disease in the left brachial plexus. Magnetic resonance imaging of the spine revealed an intramedullary spinal cord metastasis in the lower cervical cord at C6-C7. Read More

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http://dx.doi.org/10.1308/rcsann.2020.0009DOI Listing

Health-Related Quality of Life After Microscopic Total Removal of Spinal Intramedullary Ependymomas in a Single-Institute 3-Year Prospective Study.

World Neurosurg 2020 Apr 27;136:e614-e624. Epub 2020 Jan 27.

Department of Neurosurgery, Osaka City University Graduate School of Medicine, Osaka, Japan. Electronic address:

Objective: Health-related quality of life (HRQOL) after surgery for spinal intramedullary benign encapsulated tumors remains unclear. A single-institute, 3-year, prospective study was conducted to examine HRQOL after microscopic total removal of spinal intramedullary ependymomas using a safe and precise strategy.

Methods: A cohort of 20 patients with a possible diagnosis of spinal intramedullary benign ependymomas was recruited. Read More

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http://dx.doi.org/10.1016/j.wneu.2020.01.126DOI Listing

T10-L3 Cystic Lesion of the Ventriculus Terminalis Presenting as Conus Medullaris Syndrome.

World Neurosurg 2020 Apr 16;136:146-149. Epub 2020 Jan 16.

Department of Neurologic Surgery, Mayo Clinic, Jacksonville, Florida, USA. Electronic address:

Background: Intramedullary spinal cord cysts are benign, rare, fluid-filled lesions that can present anywhere along the craniospinal axis. However, when present at the level of the ventriculus terminalis, conus medullaris syndrome may occur. Radical resection of the cyst wall and evacuation of the cyst content are the 2 surgical procedures of choice. Read More

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http://dx.doi.org/10.1016/j.wneu.2020.01.049DOI Listing
April 2020
2.417 Impact Factor

How to differentiate spinal cord hemangiopericytoma from common spinal cord tumor?

Neurochirurgie 2020 Feb 14;66(1):53-55. Epub 2020 Jan 14.

Hospices Civils de Lyon, Hôpital P. Wertheimer, Service de Neurochirurgie D, 59, Boulevard Pinel, 69003, Lyon, France; Université de Lyon, Université Claude-Bernard, 69003 Lyon, France; Laboratoire CREATIS, CNRS UMR5220, Inserm U1206, INSA-Lyon; Université de Lyon I, 69006 Lyon, France.

Introduction: Tumors of the spinal cord are rare and some can be confused with each other. We report a rare spinal cord solitary fibrous tumor/hemangiopericytoma (SFT/HPC), and propose keys to differentiate spinal cord tumors from each other.

Case Report: A 67-year-old man presented weakness with recent diffuse sensory disorders in the right lower limb. Read More

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http://dx.doi.org/10.1016/j.neuchi.2019.10.012DOI Listing
February 2020

Surgical management of spinal intramedullary tumors: Ten-year experience in a single institution.

J Clin Neurosci 2020 Mar 10;73:201-208. Epub 2020 Jan 10.

Department of Neurosurgery, Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa, Istanbul, Turkey.

Despite their rare occurrence, intramedullary spinal cord tumors can cause considerable morbidity and mortality without treatment. Timing of surgery, extent of resection and selection of favorable treatment option are important considerations for a good surgical outcome. In this clinical study, we report our patient series and convey our treatment strategy. Read More

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http://dx.doi.org/10.1016/j.jocn.2019.12.054DOI Listing

Spectrum of Complications in a Case of Intramedullary Dermoid.

World Neurosurg 2020 Apr 7;136:37-43. Epub 2020 Jan 7.

Department of Neurosurgery, Command Hospital (Southern Command), Pune, India.

Background: Intramedullary spinal cord dermoid tumors are rare. Early diagnosis with appropriate imaging is of utmost importance for a good outcome. Gross total resection is the treatment of choice for optimal results. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.12.171DOI Listing
April 2020
2.417 Impact Factor

Genomic Landscape of Intramedullary Spinal Cord Gliomas.

Sci Rep 2019 12 10;9(1):18722. Epub 2019 Dec 10.

Ludwig Center for Cancer Genetics, Sidney Kimmel Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.

Intramedullary spinal cord tumors (IMSCTs) are rare neoplasms that have limited treatment options and are associated with high rates of morbidity and mortality. To better understand the genetic basis of these tumors we performed whole exome sequencing on 45 tumors and matched germline DNA, including twenty-nine spinal cord ependymomas and sixteen astrocytomas. Though recurrent somatic mutations in IMSCTs were rare, we identified NF2 mutations in 15. Read More

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http://dx.doi.org/10.1038/s41598-019-54286-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6904446PMC
December 2019
5 Reads

Clinical and surgical management of holocervical spinal cord ependymomas.

Surg Neurol Int 2019 22;10:223. Epub 2019 Nov 22.

Departments of Neurosurgery, University of California, Los Angeles.

Background: Spinal ependymomas are rare tumors of the central nervous system, and those spanning the entire cervical spine are atypical. Here, we present two unusual cases of holocervical (C1-C7) spinal ependymomas.

Case Description: Two patients, a 32-year-old female and a 24-year-old male presented with neck pain, motor, and sensory deficits. Read More

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http://dx.doi.org/10.25259/SNI_374_2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6884946PMC
November 2019

Posterolateral myelotomy for intramedullary spinal cord tumors: the other way to do it?

Acta Neurochir (Wien) 2020 01 6;162(1):101-107. Epub 2019 Dec 6.

Department of Neurosurgery, University Hospital of Bochum, In der Schornau Str. 23-25, 44892, Bochum, Germany.

Background And Purpose: To evaluate posterolateral myelotomy (PLM) as a surgical method for all cases of intramedullary spinal cord tumors (IMSCT) by assessing the surgical and functional outcomes of patients treated in our clinic.

Materials And Methods: Patients with IMSCT who underwent surgery using PLM from 2013 to 2018 were reviewed retrospectively. Objective and quantitative assessment of the preoperative, postoperative, and follow-up neurological status was performed by using the modified McCormick functional schema and sensory pain scale. Read More

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http://dx.doi.org/10.1007/s00701-019-04151-5DOI Listing
January 2020

Spinal rosette-forming glioneuronal tumor: A case report.

Medicine (Baltimore) 2019 Dec;98(49):e18271

Department of Cancer Pathology, Hokkaido University Faculty of Medicine, Sapporo, Japan.

Rationale: Rosette-forming glioneuronal tumor (RGNT) is a rare tumor which has been first reported as the fourth ventricle tumor by Komori et al and is classified as a distinct clinicopathological entity by the WHO Classification of Tumors of the Central Nervous System as in 2007. Although RGNTs were reported to occur in both supratentorial and inflatentorial sites, only 4 case reports of spinal RGNT have been demonstrated.

Patient Concerns: A 37-year-old female presenting with slowly progressing right-sided clumsiness. Read More

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http://dx.doi.org/10.1097/MD.0000000000018271DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6919525PMC
December 2019
5 Reads

Intramedullary spinal cord germinoma clinically mimicking multiple sclerosis: A case report.

Surg Neurol Int 2019 11;10:201. Epub 2019 Oct 11.

Department of Neurosurgery, Juntendo University, Hongo, Tokyo, Japan.

Background: It is important to differentiate intramedullary neoplastic lesions from nonneoplastic diseases such as multiple sclerosis (MS) and other demyelinating or inflammatory diseases.

Case Description: A 26-year-old Japanese male presented with a history of intracranial germinomas and obstructive hydrocephalus, treated with endoscopic surgery, and adjuvant chemotherapy and radiation therapy. Three years later, he developed paresthesias involving the right hand and both lower extremities. Read More

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http://dx.doi.org/10.25259/SNI_466_2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826275PMC
October 2019

Role of Diffusion Tensor Imaging Parameters in the Characterization and Differentiation of Infiltrating and Non-Infiltrating Spinal Cord Tumors : Preliminary Study.

Clin Neuroradiol 2019 Nov 21. Epub 2019 Nov 21.

2nd Department of Clinical Radiology, Medical University of Warsaw, ul. Zwirki i Wigury 61, 02-091, Warsaw, Poland.

Background And Purpose: Recent attempts to utilize diffusion tensor imaging (DTI) to identify the extent of microinfiltration of a tumor in the brain have been successful. It was therefore speculated that this technique could also be useful in the spinal cord. The aim of this study was to differentiate between infiltrating and noninfiltrating intramedullary spinal tumors using DTI-derived metrics. Read More

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http://dx.doi.org/10.1007/s00062-019-00851-8DOI Listing
November 2019

Giant Cell-rich Tanycytic Ependymoma as Intramedullary Spinal Mass.

Neurol India 2019 Sep-Oct;67(5):1327-1330

Department of Neurosurgery, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Intramedullary spinal cord tumors are rare neoplasms and harbour full spectrum of primary neoplasms as seen within the intracranial compartment. They include tumors with diverse pathologies, arising in both adults and children and pose considerable diagnostic challenge. The differentials at this site include wide ranging pathologies from benign, circumscribed pilocytic to diffuse astrocytoma, myxopapillary or tanycytic ependymoma and malignant diffuse midline glioma. Read More

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http://dx.doi.org/10.4103/0028-3886.271272DOI Listing

Intramedullary Spinal Metastatic Renal Cell Carcinoma: Systematic Review of Disease Presentation, Treatment, and Prognosis with Case Illustration.

World Neurosurg 2020 Feb 14;134:584-593. Epub 2019 Nov 14.

Department of Neurological Surgery, University of Texas Southwestern, Dallas, Texas, USA.

Objective: Renal cell carcinoma (RCC) metastases to the intramedullary spinal cord carry a grim prognosis. The purpose of this review is to provide the reader with a comprehensive and systematic review of the current literature, and to present an illustrative case that would aid in the future management of similar scenarios.

Methods: A systematic review of the literature using the PubMed electronic database was made according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.11.056DOI Listing
February 2020

Extramedullary tanycytic ependymoma of the lumbar spinal cord.

Yeungnam Univ J Med 2020 Apr 11;37(2):128-132. Epub 2019 Nov 11.

Department of Forensic Medicine, School of Medicine, Kyungpook National University, Daegu, Korea.

Tanycytic ependymoma is a rare variant of ependymoma that commonly affects the cervical and thoracic spinal cord. It usually arises as intramedullary lesions, and extramedullary cases are extremely rare. We report a case of a 44-year-old woman who was diagnosed with tanycytic ependymoma in her lumbar spine at level 2-3. Read More

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http://dx.doi.org/10.12701/yujm.2019.00367DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7142023PMC

Intradural Extramedullary Nonconus Nonfilum Spinal Ependymomas: Report of a Rare Variant and Newer Insights into Their Histogenesis with Proposal of a Classification Scheme and a Management Algorithm Based on a Review of Literature.

World Neurosurg 2020 Feb 1;134:323-336. Epub 2019 Nov 1.

Department of Neurosurgery, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.

Background: Ependymomas are common intramedullary spinal tumors but there are scattered reports of this tumor presenting with exophytic growth patterns masquerading as intradural extramedullary (IDEM) tumors. Such IDEM ependymomas are seldom suspected preoperatively and it is only during surgery that their existence is revealed. Little is known of such rare growth patterns of an otherwise common intramedullary spinal cord tumor, their characteristics, and their management considerations. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.10.152DOI Listing
February 2020

Intramedullary teratoma.

Autops Case Rep 2019 Oct-Dec;9(4):e2019105. Epub 2019 Sep 18.

Universidade de São Paulo (USP), Hospital das Clínicas, Department of Pathology. São Paulo, SP, Brazil.

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http://dx.doi.org/10.4322/acr.2019.105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6771445PMC
September 2019
1 Read

Rare Cervicothoracic Intramedullary and Extramedullary Lipoma.

World Neurosurg 2020 Jan 16;133:275-277. Epub 2019 Oct 16.

Department of Functional Neurosurgery, Honghui Hospital, Xi'an Jiaotong University, Beilin District, Xi'an, Shaanxi Province, China.

We report a rare case of cervicothoracic intramedullary and extramedullary lipoma. Complete resection of the extramedullary lipoma and almost complete resection of the intramedullary lipoma were performed using a microscope, followed by posterior fusion and internal fixation from C4-T2 to maintain the stability of the cervicothoracic junction. Despite the high risk, it was still necessary to perform the decompression surgery and the surgical results were favorable. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.10.049DOI Listing
January 2020
1 Read

Prolonged survival in a patient with a cervical spine H3K27M-mutant diffuse midline glioma.

BMJ Case Rep 2019 Oct 17;12(10). Epub 2019 Oct 17.

Neurology, University of Michigan, Ann Arbor, Michigan, USA

We report a case of prolonged survival in a patient with known cervical intramedullary H3K27M-mutant diffuse midline glioma. A 39-year-old man presented for evaluation with several months of progressive upper extremity pain and weakness. MRI of the cervical spine revealed an intramedullary ring-enhancing lesion centred at C3-C4. Read More

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http://dx.doi.org/10.1136/bcr-2019-231424DOI Listing
October 2019
2 Reads

Comparative clinical study on seldom segment with multiple segment intramedullary primary spinal cord tumors.

Beijing Da Xue Xue Bao Yi Xue Ban 2019 Oct;51(5):840-850

Department of Neurosurgery, Peking University Third Hospital, Beijing 100191, China.

Objective: Several clinical studies were performed on multi-segment intramedullary primary spinal cord tumors. However, no clinical study focused on the relationship between different vertebral segments intramedullary tumors involvement and neurological functions, as well as prognosis of the patients. This prospective study was performed to compare clinical analysis on neurological functions and prognosis of the patients with intramedullary spinal cord primary tumors. Read More

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October 2019

Nomograms Predict Survival Outcome of Primary Intramedullary Spinal Cord Lymphoma Patients.

Med Sci Monit 2019 Oct 3;25:7418-7429. Epub 2019 Oct 3.

Department of Radiation Oncology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China (mainland).

BACKGROUND Primary intramedullary spinal cord lymphoma (PISCL) is a rare cause of myelopathies. Considering its poor prognosis, it is essential to determine the appropriate treatment strategies and to develop nomograms to predict survival outcome for PISCL patients. MATERIAL AND METHODS Data were collected from the Surveillance, Epidemiology and End Results (SEER) database. Read More

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http://dx.doi.org/10.12659/MSM.919628DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6791184PMC
October 2019
3 Reads

Spinal cord atypical teratoid/rhabdoid tumors in children: Clinical, genetic, and outcome characteristics in a representative European cohort.

Pediatr Blood Cancer 2020 01 1;67(1):e28022. Epub 2019 Oct 1.

Swabian Children's Cancer Center, University Children's Hospital, University Hospital Augsburg, Augsburg, Germany.

Background: Case reports have portrayed spinal cord atypical teratoid/rhabdoid tumor (spATRT) as an aggressive form of ATRT. We conducted a retrospective European survey to collect data on clinical characteristics, molecular biology, treatment, and outcome of children with intramedullary spATRT.

Methods: Scrutinizing a French national series and the European Rhabdoid Registry database, we identified 13 patients (median age 32 months; metastatic disease at diagnosis, n = 6). Read More

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http://dx.doi.org/10.1002/pbc.28022DOI Listing
January 2020
2 Reads

Intramedullary spinal cord tumors: the value of intraoperative neurophysiological monitoring in a series of 57 cases from two Italian centres.

J Neurosurg Sci 2019 Sep 23. Epub 2019 Sep 23.

Department of Neurosurgery, Humanitas Clinical Research Hospital, Neurocenter, Rozzano, Milan, Italy.

Background: Intramedullary spinal cord tumors are rare lesions of the central nervous system. Anatomical, molecular and radiological features are well defined, but correct management is still matter of debate. Pertinent literature has reported conflicting opinions regarding the use of intraoperative electrophysiological monitoring (IONM) in the surgical treatment of this kind of lesions, recently. Read More

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http://dx.doi.org/10.23736/S0390-5616.19.04758-1DOI Listing
September 2019
4 Reads

Primary Spinal Astrocytomas: A Literature Review.

Cureus 2019 Jul 26;11(7):e5247. Epub 2019 Jul 26.

Neurosurgery, Kaiser Permanente - Fontana Medical Center, Fontana, USA.

Primary spinal astrocytoma is a subtype of glioma, the most common spinal cord tumor found in the intradural intramedullary compartment. Spinal astrocytomas account for 6-8% of all spinal cord tumors and are primarily low grade (World Health Organization grade I (WHO I) or WHO II). They are seen in both the adult and pediatric population with the most common presenting symptoms being back pain, sensory dysfunction, or motor dysfunction. Read More

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http://dx.doi.org/10.7759/cureus.5247DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6759039PMC
July 2019
2 Reads

An intramedullary "flame" recognized as being an intramedullary spinal cord metastasis from esophageal cancer.

J Radiol Case Rep 2019 Jul 31;13(7):14-20. Epub 2019 Jul 31.

Neuroradiology Service, Department of Radiology, University of Campania "Luigi Vanvitelli", Naples, Italy.

Intramedullary spinal cord metastases are rarely encountered in patients suffering from extra - central nervous system primary cancer, with only 2 described cases reported in the literature deriving from esophageal cancer. Intramedullary spinal cord metastases may occur at any level of the spinal cord but cervical location is the most frequent. We report the first case of intramedullary metastasis affecting the thoracic spinal cord from esophageal squamous cell carcinoma in a 35-year-old patient. Read More

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http://dx.doi.org/10.3941/jrcr.v13i7.3555DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6738491PMC

Identification of differentially expressed genes and fusion genes associated with malignant progression of spinal cord gliomas by transcriptome analysis.

Sci Rep 2019 09 19;9(1):13583. Epub 2019 Sep 19.

Department of neurosurgery, Beijing Tsinghua Changgung Hospital, Beijing, 102218, China.

Glioma, the most common histological subtype of primary spinal cord tumors, is considered as a rare central nervous system neoplasm. In this study, 9 glioma samples (4 of grade II and 5 of grade IV with H3K27M positive) were analyzed to examine the molecular mechanisms underlying the malignant progression of gliomas, transcriptome sequencing. Differentially expressed genes (DEGs) in grade IV vs. Read More

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http://dx.doi.org/10.1038/s41598-019-50072-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6753211PMC
September 2019
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The Ubiquitination of Spinal MrgC Alleviates Bone Cancer Pain and Reduces Intracellular Calcium Concentration in Spinal Neurons in Mice.

Neurochem Res 2019 Nov 12;44(11):2527-2535. Epub 2019 Sep 12.

Department of Anesthesiology, Affiliated Drum Tower Hospital, Nanjing University Medical College, No. 321 Zhongshan Road, Nanjing, 210008, Jiangsu, People's Republic of China.

Mas-related G-protein-coupled receptor subtype C (MrgC) has been shown to play an important role in the development of bone cancer pain. Ubiquitination is reported to participate in pain. However, whether MrgC ubiquitination plays a role in bone cancer pain remains unclear. Read More

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http://dx.doi.org/10.1007/s11064-019-02869-3DOI Listing
November 2019

Longitudinally Extensive Transverse Myelitis with Aquaporin-4 Antibody Positivity in Renal Cell Carcinoma: Rare Occurrence.

Neurol India 2019 Jul-Aug;67(4):1087-1089

Department of Neurology, MS Ramaiah Medical College and Hospital, Bangalore, Karnataka, India.

The occurrence of longitudinally extensive transverse myelitis (LETM) in an elderly patient should evoke search for underlying systemic malignancy. Intramedullary spinal cord metastases and paraneoplastic myelopathy are the most common etiology for LETM in patients with systemic malignancy. The occurrence of LETM in association with renal cell carcinoma with aquaporin-4 (AQP4) antibody positivity has not been reported. Read More

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http://dx.doi.org/10.4103/0028-3886.266293DOI Listing
March 2020
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Microsurgical Resection of Intraspinal Benign Tumors Using Non-Expansile Tubular Access.

World Neurosurg 2020 Jan 7;133:e97-e104. Epub 2019 Sep 7.

Spine Clinic, The American-British Cowdray Medical Center I.A.P. Campus Santa Fe, Mexico City, Mexico; National Autonomous University of Mexico, Mexico City, Mexico; Regional General Hospital #25 of the National Institute of Social Security, Mexico City, Mexico; Department of Neurology, Medicine School, University of Sonora, Obregon City, Mexico. Electronic address:

Background: Intraspinal tumors are 10 to 15 times less common than brain tumors. The midline approach with extensive laminectomies represents the current gold-standard for resection, causing instability, muscle damage, and kyphosis among other well-known complications. Minimally invasive series reported their results using retractor-based systems. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.08.170DOI Listing
January 2020
3 Reads

Microsurgical Resection of Brain Stem Ependymoma: 2-Dimensional Operative Video.

Oper Neurosurg (Hagerstown) 2020 Jun;18(6):E240-E241

Department of Neurosurgery, University of Tennessee Health Science Center, Memphis, Tennessee.

The brainstem is a less-common location for ependymomas than the spinal cord where they are the most common adult intramedullary tumor.1-18 In this first video case report in the peer-reviewed literature, we demonstrate microsurgical resection of a medulla oblongata ependymoma.  There are several case reports of medulla oblongata ependymomas1,3,5,6,13 and a few series of spinal cord ependymomas that included cases of ependymomas of the cervicomedullary junction. Read More

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https://academic.oup.com/ons/advance-article/doi/10.1093/ons
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http://dx.doi.org/10.1093/ons/opz252DOI Listing
June 2020
3 Reads

Magnetic resonance imaging findings of an intradural extramedullary hemangiosarcoma in a dog.

J Vet Med Sci 2019 Oct 4;81(10):1527-1532. Epub 2019 Sep 4.

Faculty of Veterinary Medicine, Okayama University of Science, 1-3 Ikoinooka, Imabari, Ehime 794-8555, Japan.

An 11-year-old male Miniature Dachshund was referred for acute neurological deficits in the pelvic limbs. T2-weighted magnetic resonance imaging revealed that the spinal cord at the L1-2 intervertebral disc space was heterogeneously hyperintense in the sagittal plane and was mildly compressed from the ventral side by a small hypointense mass in the transverse plane. However, the lesion showed mass enhancement and severe spinal cord compression on post-contrast T1-weighted imaging. Read More

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http://dx.doi.org/10.1292/jvms.19-0260DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6863723PMC
October 2019
1 Read

Clinical outcomes and prognostic factors for cavernous hemangiomas of the spinal cord: a retrospective cohort study

J Neurosurg Spine 2019 04 12;31(2):271-278. Epub 2019 Apr 12.

Departments of Orthopaedic Surgery

Objective: Intramedullary cavernous hemangioma (CH) is a rare vascular lesion that is mainly characterized by the sudden onset of hemorrhage in young, asymptomatic patients, who then experience serious neurological deterioration. Despite the severity of this condition, the therapeutic approach and timing of intervention for CH remain matters of debate. The aim of this study was to evaluate the clinical characteristics of CH patients before and after surgery and to identify prognostic indicators that affect neurological function in these patients. Read More

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http://dx.doi.org/10.3171/2019.1.SPINE18854DOI Listing
April 2019
5 Reads