2,331 results match your criteria Intramedullary Spinal Cord Tumors


Dorsal Spinal Intradural Intramedullary Epidermoid Cyst: A Rare Case Report and Review of Literature.

J Neurosci Rural Pract 2019 Apr-Jun;10(2):352-354

Department of Pathology, Osmania Medical College, Hyderabad, Telangana, India.

Epidermoid cysts are commonly seen intracranial lesions but their occurrence in the spine is rare. They account for <1% of all the benign tumors of the spine. These are benign epithelial-lined cysts filled with keratin. Read More

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http://dx.doi.org/10.4103/jnrp.jnrp_304_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454963PMC

Spinal Cord Ependymoma - Surgical Management and Outcome.

J Neurosci Rural Pract 2019 Apr-Jun;10(2):316-320

Department of Neurosurgery, Beaumont Hospital, Dublin, Ireland.

Background: Ependymoma is a common primary neoplasm of the spinal cord and filum terminale. Patients with spinal ependymoma usually experience gradual symptoms due to slow progression of the tumor; thus, early diagnosis can be challenging to make.

Objective: The objective of this study was to report 5 years' experience in treating spinal intramedullary ependymomas and to illustrate the advantage of aggressive complete resection whenever possible. Read More

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http://dx.doi.org/10.4103/jnrp.jnrp_267_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454966PMC

Phase I study of intermittent high dose lapatinib alternating with capecitabine for HER2-positive breast cancer patients with central nervous system metastases.

Clin Cancer Res 2019 Apr 15. Epub 2019 Apr 15.

Medicine, Memorial Sloan Kettering Cancer Center

Purpose: Lapatinib and capecitabine cross the blood tumor-barrier in breast cancer brain metastasis but have modest clinical efficacy. Administration of high dose tyrosine kinase inhibitor (TKI) has been evaluated in brain metastases and primary brain tumors as a strategy to improve drug exposure in the central nervous system (CNS).We derived a rational drug scheduling of intermittent high dose lapatinib alternating with capecitabine-basedon our preclinical data and Norton-Simon mathematical modeling. Read More

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http://dx.doi.org/10.1158/1078-0432.CCR-18-3502DOI Listing
April 2019
1 Read

68Ga DOTATATE PET/CT Versus 18F-FDG PET/CT for Detecting Intramedullary Hemangioblastoma in a Patient With Von Hippel-Lindau Disease.

Clin Nucl Med 2019 Apr 12. Epub 2019 Apr 12.

Nuclear Medicine & Molecular Imaging Department, Imam Reza International University, Mashhad, Iran.

Von Hippel-Lindau disease is an inherited syndrome associated with several benign and malignant tumors such as central nervous system (CNS) hemangioblastoma. Herein, we report a known case of A Von Hippel-Lindau patient with a cerebral hemangioblastoma who was referred for further evaluation because of recent paraparesis. F-FDG PET/CT showed no focal uptake in the thoracic spine, which demonstrated increased Ga DOTATATE activity, owing to overexpression of somatostatin receptors, suggesting spinal cord hemangioblastoma. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002565DOI Listing
April 2019
1 Read

Novel Technique of Coregistered Intraoperative Computed Tomography and Preoperative Magnetic Resonance Imaging and Diffusion Tensor Imaging Navigation in Spinal Cord Tumor Resection.

Ochsner J 2019 ;19(1):43-48

Department of Neurological Surgery, Ochsner Clinic Foundation, New Orleans, LA.

Intradural spinal tumors are surgically challenging lesions, and intraoperative spinal navigation offers clear potential assistance. While intraoperative computed tomography (iCT) of bony anatomy is routinely performed, coregistration with magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI) to facilitate intradural spinal tumor resection is not widely described. We present 2 cases in which iCT was coregistered with MRI and DTI for navigational guidance in the resection of intradural spinal tumors to assess technical feasibility and surgical efficacy. Read More

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http://dx.doi.org/10.31486/toj.18.0107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447210PMC
January 2019
1 Read

Unusual Exophytic Appearance of Spinal Cord Subependymoma.

World Neurosurg 2019 Apr 4. Epub 2019 Apr 4.

Department of Neurosurgery, Cedars-Sinai Medical Center, 127 S San Vicente Blvd, AHSP A6600, Los Angeles, CA 90048, USA. Electronic address:

Background: Subependymomas are rare in the spinal cord. They are typically expansile, intramedullary spinal cord masses, eccentrically located with minimal gadolinium enhancement.

Case Description: We present a case of subependymoma originating from the cervical cord with an unusual exophytic appearance. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.03.270DOI Listing
April 2019
2 Reads

Intramedullary Spinal Cord Ganglioglioma Presenting as Hyperhidrosis: A Rare Case Report and literature Review.

World Neurosurg 2019 Mar 20. Epub 2019 Mar 20.

Departments of Neurosurgery, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, China. Electronic address:

Background: Hyperhidrosis is caused by sympathetic dysfunction of the central or peripheral nervous system. However, intramedullary spinal cord tumors presenting with hyperhidrosis as an initial symptom had been rarely reported in the literature.

Case Description: This case involves an 18-year-old man who presented with abnormal enhanced sweating and flushing on the bilateral side of his face and neck that had persisted for 6 years. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.03.115DOI Listing
March 2019
1 Read

Holocord Pilocytic Astrocytoma in an Adult: A Rare Case Report and Review of the Literature.

World Neurosurg 2019 Mar 19. Epub 2019 Mar 19.

Memorial Hospital, Neurosurgery Clinic, Ankara, Turkey.

Background: Intramedullary glial neoplasms affecting the entire spinal cord from the cervicomedullary junction to conus medullaris are termed 'holocord tumors'. Pilocytic astrocytomas are relatively uncommon tumors forming holocord involvement. Hitherto 24 holocord astrocytoma cases were reported in the literature. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.03.103DOI Listing
March 2019
1 Read
2.417 Impact Factor

Combined Use of Diffusion Tractography and Advanced Intraoperative Imaging for Resection of Cervical Intramedullary Spinal Cord Neoplasms: A Case Series and Technical Note.

Oper Neurosurg (Hagerstown) 2019 Mar 20. Epub 2019 Mar 20.

Department of Neurosurgery, NYU Langone Medical Center, New York, New York.

Background: Intramedullary spinal cord neoplasms (ISCN) pose significant management challenges. Advances in magnetic resonance imaging (MRI) (such as diffusion tensor imaging, DTI) have been utilized to determine the infiltrative nature and resectability of ISCN. However, this has not been applied to intraoperative decision making. Read More

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http://dx.doi.org/10.1093/ons/opz039DOI Listing
March 2019
1 Read

Quantitative Analysis of Near-Infrared Indocyanine Green Videoangiography for Predicting Functional Outcomes After Spinal Intramedullary Ependymoma Resection.

Oper Neurosurg (Hagerstown) 2019 Mar 19. Epub 2019 Mar 19.

Department of Neurosurgery, Osaka City University Graduate School of Medicine, Osaka, Japan.

Background: One of the most critical steps in surgery for spinal intramedullary ependymomas is the resection of small feeding arteries from the anterior spinal artery with anatomical preservation of the normal circulation of the ventral spinal cord.

Objective: To quantitatively analyze the microcirculation of the ventral spinal cord by near-infrared indocyanine green videoangiography (ICG-VA) after the spinal intramedullary ependymoma resection.

Methods: This retrospective study included 12 patients (7 male and 5 female; average age 55. Read More

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http://dx.doi.org/10.1093/ons/opz040DOI Listing
March 2019
1 Read

Subependymoma involving multiple spinal cord levels: A clinicopathological case series with chromosomal microarray analysis.

Neuropathology 2019 Apr 11;39(2):97-105. Epub 2019 Mar 11.

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.

Subependymomas of the spinal cord are rare, do not often involve multiple levels, and very rarely recur. Here, we present a series of spinal cord subependymomas with a detailed description of the clinical, radiological and pathological features, and characterization by chromosomal microarray analysis. Briefly, the four patients included two men and two women, between the ages of 22 and 48 years. Read More

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http://dx.doi.org/10.1111/neup.12543DOI Listing
April 2019
1 Read

Multiple spinal intramedullary PNETs mimicking acute myelitis: a case report.

World Neurosurg 2019 Mar 1. Epub 2019 Mar 1.

Department of Radiology, Shaanxi Provincial People's Hospital. Electronic address:

Background: Primitive neuroectodermal tumors (PNETs) are rare malignant neoplasms in the spinal cord that comprise undifferentiated or poorly differentiated neural crest cells. PNETs imaging findings lack specificity, making diagnosis difficult.

Case Description: A 16-year-old man presented with progressive weakness and numbness of the lower extremities for 1 month, which occurred after a cold. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.02.108DOI Listing
March 2019
1 Read

Unusual radiological and histological presentation of a diffuse leptomeningeal glioneuronal tumor (DLGNT) in a 13-year-old girl.

Childs Nerv Syst 2019 Feb 15. Epub 2019 Feb 15.

Department of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, Los Angeles, CA, 90027, USA.

Diffuse leptomeningeal glioneuronal tumors (DLGNTs) are newly recognized as an entity in the 2016 revision of the WHO Classification of tumors of the central nervous system. They typically present as diffuse leptomeningeal infiltrates along the neuraxis with focal and superficial involvement of the parenchyma. Here, we report a DLGNT with unusual radiological and histological features. Read More

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http://dx.doi.org/10.1007/s00381-019-04074-7DOI Listing
February 2019
4 Reads

Stratification of Grade of Spinal Cord Non-Ependymal Gliomas by Magnetic Resonance Imaging.

World Neurosurg 2019 Feb 10. Epub 2019 Feb 10.

Department of Radiology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, China. Electronic address:

Objective: The purpose of this study was to demonstrate the usefulness of conventional magnetic resonance imaging (MRI) in stratification of spinal cord non-ependymal gliomas.

Methods: Forty-one patients (mean age, 29.9 ± 16. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.01.205DOI Listing
February 2019
5 Reads
2.417 Impact Factor

Risk factor analysis of progressive spinal deformity after resection of intramedullary spinal cord tumors in patients who underwent laminoplasty: a report of 105 consecutive cases.

J Neurosurg Spine 2019 Feb 8:1-9. Epub 2019 Feb 8.

Departments of1Neurosurgery and.

OBJECTIVELaminoplasty has been used in recent years as an alternative approach to laminectomy for preventing spinal deformity after resection of intramedullary spinal cord tumors (IMSCTs). However, controversies exist with regard to its real role in maintaining postoperative spinal alignment. The purpose of this study was to examine the incidence of progressive spinal deformity in patients who underwent laminoplasty for resection of IMSCT and identify risk factors for progressive spinal deformity. Read More

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http://dx.doi.org/10.3171/2018.10.SPINE18110DOI Listing
February 2019
2 Reads

Xenografting for disease modeling of intramedullary spinal cord tumors: a systematic review.

Spinal Cord 2019 Feb 1. Epub 2019 Feb 1.

Department of Neurosurgery, University Hospital Essen, Essen, Germany.

Study Design: Systematic review.

Objectives: The overall incidence of intramedullary spinal cord tumors (IMSCT) remains low and clinical trials or standardized treatment strategies are missing. Therefore, multiple animal-based xenograft models (AXM) have been developed to foster preclinical research efforts on IMSCT. Read More

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http://www.nature.com/articles/s41393-019-0248-6
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http://dx.doi.org/10.1038/s41393-019-0248-6DOI Listing
February 2019
6 Reads

Intraoperative Neuromonitoring in Patients with Intramedullary Spinal Cord Tumor: A Systematic Review, Meta-Analysis, and Case Series.

World Neurosurg 2019 Jan 17. Epub 2019 Jan 17.

Department of Neurosurgery, Erasmus University Medical Centre, Rotterdam, The Netherlands. Electronic address:

Background: Intramedullary spinal cord tumors (IMSCT) comprise the least common types of spinal neoplasms; surgery is mostly conducted with intraoperative neuromonitoring (IONM). However, although IONM is widely used to prevent neurologic damage and many single-center studies have been reported, the added value, in terms of overall sensitivity and specificity, of different monitoring techniques used in IMSCT surgery remains to be clearly defined.

Objective: To summarize and review the reported evidence on the use of IONM in IMSCT surgery, including our own case series (n = 75 patients). Read More

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http://dx.doi.org/10.1016/j.wneu.2019.01.007DOI Listing
January 2019
1 Read

Intramedullary spinal cord metastases: an institutional review of survival and outcomes.

J Neurooncol 2019 Apr 17;142(2):347-354. Epub 2019 Jan 17.

Mayo Clinic Neuro-Informatics Laboratory, Department of Neurologic Surgery, Mayo Clinic, Rochester, MN, USA.

Introduction: Intramedullary spinal cord metastases (ISCMs) are rare lesions affecting the spinal cord in patients with disseminated malignancy. Today, due to increased survival, these lesions are more frequently diagnosed. Literature on survival and neurologic outcomes is sparse. Read More

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http://dx.doi.org/10.1007/s11060-019-03105-2DOI Listing
April 2019
3 Reads

Lumbar Intramedullary Epidermoid Following Repair of Sacral Myelomeningocele and Tethered Cord: A Case Report With a Review of the Relevant Literature and Operative Nuances.

Neurospine 2018 Sep 4. Epub 2018 Sep 4.

Department of Neurosurgery, Kovai Medical Center and Hospital, Coimbatore, India.

Epidermoid cysts of the spine are rare tumors. While majority of them occur spontaneously, very few occur following a previous surgery for spinal dysraphism. Such tumors tend to occur at the site of previous surgery. Read More

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http://dx.doi.org/10.14245/ns.1836152.076DOI Listing
September 2018
4 Reads

The Use of Intraoperative Ultrasonography in Intradural Spinal Tumor Surgery.

Turk Neurosurg 2019 ;29(2):237-241

Heinrich-Braun-Klinikum, Department of Neurosurgery, Zwickau, Germany.

Aim: To review our experience gained from the use of intraoperative ultrasonography (IOUSG) in intradural spinal tumor surgery.

Material And Methods: IOUSG was used during surgery of 69 intradural spinal tumors, operated on between 2012 and 2016. A 5-8 MHz probe of IOUSG was used, before and after durotomy to perform the exact durotomy and myelotomy, and after tumor resection, to detect a residual tumor. Read More

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http://dx.doi.org/10.5137/1019-5149.JTN.23296-18.3DOI Listing
April 2019
3 Reads

Spinal dural tenting sutures in intradural tumor surgery: A technical insight.

J Clin Neurosci 2019 Mar 28;61:322-323. Epub 2018 Oct 28.

A.O.U. "Sant'Andrea", Neurosurgery Division, Sapienza University, Rome, NESMOS Department, Via di Grottarossa, 1035-1039, 00189 Roma, Italy.

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http://dx.doi.org/10.1016/j.jocn.2018.10.085DOI Listing
March 2019
2 Reads

MR imaging features of spinal pilocytic astrocytoma.

BMC Med Imaging 2019 01 14;19(1). Epub 2019 Jan 14.

Department of Radiology, Huashan Hospital, Fudan University, 12 Middle Wulumuqi Road, Jingan District, Shanghai, China.

Background: The purpose of this retrospective review is to determine the MR imaging features of pilocytic astrocytoma (PA) in the spinal cord to help neuroradiologists preoperatively differentiate PA from other intramedullary tumors.

Methods: Neuro-oncology database review revealed 13 consecutive patients with a pathological spinal PA diagnosis and availability of preoperative MR imaging. Three patients had preoperative diffusion-weighted MR imaging. Read More

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http://dx.doi.org/10.1186/s12880-018-0296-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332544PMC
January 2019
2 Reads

classification of spinal cord tumors using autofluorescence spectroscopy and immunohistochemical indexes.

Biomed Opt Express 2018 Sep 21;9(9):4401-4412. Epub 2018 Aug 21.

Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing 100084, China.

Spinal cord tumors are complicated and infrequent, which poses a major challenge to surgeons during neurosurgery. Currently, the intraoperative identification of the tissues' pathological properties is usually difficult for surgeons. This issue influences the decision-making in treatment planning. Read More

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http://dx.doi.org/10.1364/BOE.9.004401DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157786PMC
September 2018
2 Reads

Crosstalk between NFκB-dependent astrocytic CXCL1 and neuron CXCR2 plays a role in descending pain facilitation.

J Neuroinflammation 2019 Jan 3;16(1). Epub 2019 Jan 3.

Department of Anesthesiology and Pain Research center, The First Affiliated Hospital of Jiaxing University, Jiaxing, 314001, China.

Background: Despite accumulating evidence on the role of glial cells and their associated chemicals in mechanisms of pain, few studies have addressed the potential role of chemokines in the descending facilitation of chronic pain. We aimed to study the hypothesis that CXCL1/CXCR2 axis in the periaqueductal gray (PAG), a co-restructure of the descending nociceptive system, is involved in descending pain facilitation.

Methods: Intramedullary injection of Walker 256 mammary gland carcinoma cells of adult female Sprague Dawley rats was used to establish a bone cancer pain (BCP) model. Read More

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https://jneuroinflammation.biomedcentral.com/articles/10.118
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http://dx.doi.org/10.1186/s12974-018-1391-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317220PMC
January 2019
8 Reads

Microsurgical Resection of Low-Grade Spinal Cord Astrocytoma: 2-Dimensional Operative Video.

Oper Neurosurg (Hagerstown) 2018 Dec 19. Epub 2018 Dec 19.

Semmes Murphey Neurologic & Spine Institute, Memphis, Tennessee.

This video demonstrates microsurgical resection of low-grade (Grade I) thoracic spinal cord astrocytoma. Astrocytomas are the most common pediatric intramedullary tumors and occur secondary to ependymomas in adults.1,2 The treatment goal should be radical gross total resection while preserving neurological function with intraoperative neuromonitoring. Read More

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https://academic.oup.com/ons/advance-article/doi/10.1093/ons
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http://dx.doi.org/10.1093/ons/opy386DOI Listing
December 2018
9 Reads

Primary spinal primitive neuroectodermal tumor: A single center series with literature review.

J Spinal Cord Med 2018 Dec 18:1-9. Epub 2018 Dec 18.

a Department of Neurosurgery , Beijing Tiantan Hospital affiliated to Capital Medical University , Beijing , People's Republic of China.

Context: Primary spinal primitive neuroectodermal tumor (PNET) of the central nervous system has a low incidence. The intraspinal case is very rare. Around 30 cases have been reported so far. Read More

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https://www.tandfonline.com/doi/full/10.1080/10790268.2018.1
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http://dx.doi.org/10.1080/10790268.2018.1547862DOI Listing
December 2018
21 Reads
1.878 Impact Factor

[Intramedullary spinal cord tumour as differential diagnosis to bilateral muscle weakness].

Ugeskr Laeger 2018 Dec;180(50)

Intramedullary spinal cord tumours (IMSCT) are rare neoplasms, which can potentially lead to severe neurologic deficits. In this case report, an 83-year-old man presented with rapidly progressive bilateral muscle weakness developed within few weeks. MRI revealed a spinal cord tumour at the C7/Th1 vertebral level. Read More

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December 2018
1 Read

Microneurosurgical Removal of a Cervical Intramedullary Tumor Via Hemilaminoplasty: 3-Dimensional Operative Video.

Oper Neurosurg (Hagerstown) 2018 Dec 12. Epub 2018 Dec 12.

Department of Neurosurgery, Yeditepe University School of Medicine, Istanbul, Turkey.

Intramedullary tumors of the spinal cord are rare and account for 2% to 8.5% of all central nervous system tumors. In adults, ependymomas are the most common intramedullary tumors. Read More

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http://dx.doi.org/10.1093/ons/opy297DOI Listing
December 2018
1 Read

Intramedullary spinal tumor-like lesions.

Acta Radiol 2018 Dec 11:284185118809540. Epub 2018 Dec 11.

4 Department of Diagnostic Imaging, Institute of Mother and Child, Warsaw, Poland.

The development of magnetic resonance imaging (MRI) has led to an increasingly frequent detection of changes in the spinal cord. The most common intramedullary lesions are: demyelinating; vascular; inflammatory; infectious; and congenital, largely called tumor-like lesions. Spinal cord tumors are relatively rare, as compared with brain tumors. Read More

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http://journals.sagepub.com/doi/10.1177/0284185118809540
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http://dx.doi.org/10.1177/0284185118809540DOI Listing
December 2018
7 Reads

Intraoperative neurophysiological monitoring for intradural extramedullary spinal tumors: predictive value and relevance of D-wave amplitude on surgical outcome during a 10-year experience.

J Neurosurg Spine 2018 Nov;30(2):259-267

4Department of Neurosurgery, Humanitas Research Hospital and University, Milan, Italy.

OBJECTIVEThe purpose of this study was to evaluate the technical feasibility, accuracy, and relevance on surgical outcome of D-wave monitoring combined with somatosensory evoked potentials (SSEPs) and motor evoked potentials (MEPs) during resection of intradural extramedullary (IDEM) spinal tumors.METHODSClinical and intraoperative neurophysiological monitoring (IONM) data obtained in 108 consecutive patients who underwent surgery for IDEM tumors at the Institute for Scientific and Care Research "ASMN" of Reggio Emilia, Italy, were prospectively entered into a database and retrospectively analyzed. The IONM included SSEPs, MEPs, and-whenever possible-D-waves. Read More

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https://thejns.org/view/journals/j-neurosurg-spine/aop/artic
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http://dx.doi.org/10.3171/2018.7.SPINE18278DOI Listing
November 2018
13 Reads

Intramedullary spinal cord ependymoma and astrocytoma: intraoperative frozen-section diagnosis, extent of resection, and outcomes.

J Neurosurg Spine 2018 Oct;30(1):133-139

Departments of1Neurosurgery and.

OBJECTIVEThe intraoperative differentiation of ependymomas from astrocytomas is important because neurosurgical strategies differ between these two tumor groups. Previous studies have reported that the diagnostic accuracy of intraoperative frozen sections of intracranial central nervous system (CNS) tumors is higher than 83%-97%, whereas that for spinal intramedullary tumors remains unknown. Herein, authors tested the hypothesis that intraoperative frozen-section diagnosis is the gold standard for a differential diagnosis of intramedullary spinal cord tumors. Read More

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http://dx.doi.org/10.3171/2018.7.SPINE18230DOI Listing
October 2018
4 Reads

A case report of an intramedullary cervical teratoma in an adult patient with cervical spondylotic radiculopathy.

Neurocirugia (Astur) 2018 Oct 25. Epub 2018 Oct 25.

Servicio de Neurocirugía, Módulo de Columna, Hospital Regional 1° de Octubre, ISSSTE, Mexico City, Mexico.

Spinal cord teratomas are rare. There are few reports of teratomas affecting the cervical spine and their association with spondylotic radiculopathy has not been described. A 59-year-old woman with history of fecal incontinence attended with cervical radicular pain radiating to upper limbs. Read More

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http://dx.doi.org/10.1016/j.neucir.2018.09.001DOI Listing
October 2018
3 Reads

Exophytic Primary Intramedullary Spinal Cord Glioblastoma: Case Report and Critical Review of Literature.

World Neurosurg 2019 Feb 23;122:573-576. Epub 2018 Nov 23.

Department of Radiology, Huashan Hospital, Fudan University, Jing'an District, Shanghai, China. Electronic address:

Background: Primary intramedullary spinal cord (IMSC) glioblastoma (GBM) is an extremely rare entity; we report the first case of primary IMSC GBM presenting with exophytic involvement. The prognosis of glioblastoma remains poor due to the aggressive nature of the disease and lack of effective treatment.

Case Description: A 27-year-old Asian female presented to our hospital with a 1-month history of dysuria, incomplete bladder emptying, progressive numbness, and weakness of both lower limbs, as well as a 1-year history of back pain. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750183266
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http://dx.doi.org/10.1016/j.wneu.2018.11.113DOI Listing
February 2019
13 Reads

Intramedullary Spinal Cord Lipoma Mimicking a Late Subacute Hematoma.

Asian J Neurosurg 2018 Oct-Dec;13(4):1282-1284

Department of Neurosurgery, University Hospital Center Zagreb, University of Zagreb, School of Medicine, Zagreb, Croatia.

Spinal cord lipomas are rare and benign tumors which may cause progressive neurological deficits due to their local expansion. We present the case of a 59-year-old male patient with severe lumbosacral pain and slowly progressive paresis of the right leg, misdiagnosed with degenerative spine disease. Repeated magnetic resonance (MR) T1-weighted images of the thoracic spine suggested a subacute intramedullary hematoma. Read More

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http://dx.doi.org/10.4103/ajns.AJNS_112_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6208254PMC
November 2018
18 Reads

Progressive Feeding Intolerance Secondary to a Congenital Spinal Teratoma in a Four-week-old Female.

Cureus 2018 Sep 11;10(9):e3281. Epub 2018 Sep 11.

Pediatrics, University of Illinois College of Medicine At Peoria, Peoria, USA.

A poorly feeding neonate presents the clinician with a diagnostic challenge. Feeding difficulties and irritability may be due to sepsis, congenital heart disease, inborn errors of metabolism, non-accidental head trauma, as well as a vast variety of other pathologies. Teratomas are rare pediatric tumors that can occasionally present in the immediate neonatal period and can manifest in the infant's central nervous system (CNS) with non-specific symptoms of poor feeding, lethargy, and somnolence. Read More

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https://www.cureus.com/articles/13804-progressive-feeding-in
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http://dx.doi.org/10.7759/cureus.3281DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6235640PMC
September 2018
14 Reads

Prophylactic enlargement of the thecal sac volume by spinal expansion duroplasty in patients with unresectable malignant intramedullary tumors and metastases prior to radiotherapy.

Neurosurg Rev 2018 Nov 14. Epub 2018 Nov 14.

Department of Neurosurgery, Medical Center, Georg August University of Göttingen, Göttingen, Germany.

Unresectable malignant intramedullary tumors and metastases usually require radiotherapy which intensifies spinal cord edema and might result in neurological decline. Spinal expansion duroplasty before radiotherapy enlarges the intrathecal volume and might thus prevent neurological deficits. The study aims to evaluate the clinical course of patients undergoing expansion duroplasty. Read More

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http://dx.doi.org/10.1007/s10143-018-1051-0DOI Listing
November 2018

Intramedullary schwannoma of conus medullaris: rare site for a common tumor with review of literature.

Spinal Cord Ser Cases 2018 6;4:99. Epub 2018 Nov 6.

3Department of Radiology, Institute of Human Behaviour and Allied Sciences, Delhi, India.

Introduction: Schwannomas at an intramedullary location constitute only 0.3% of primary spinal tumors. Those in the conus are extremely rare, especially in the absence of neurofibromatosis, with only 12 cases reported in the literature so far, excluding the present case. Read More

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http://dx.doi.org/10.1038/s41394-018-0134-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219485PMC
November 2018
2 Reads

Results of TachoSil® associated with fibrin glue as dural sealant in a series of patients with spinal intradural tumors surgery. Technical note with a review of the literature.

J Clin Neurosci 2019 Mar 7;61:88-92. Epub 2018 Nov 7.

Institute of Neurosurgery, Catholic University, Rome, Italy.

A major problem of surgery for intradural spinal tumors (IST) is the occurrence in the post-operative period of a cerebrospinal fluid (CSF) leak. To the best of our knowledge, here we report on the largest series of IST patients in whom the TachoSil® associated to fibrin glue was used as dural sealant in this kind of surgery. Moreover, we extensively reviewed the literature reporting the results of TachoSil® in spine surgery. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09675868183117
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http://dx.doi.org/10.1016/j.jocn.2018.10.138DOI Listing
March 2019
15 Reads

Giant bipolar intramedullary nondysraphic spinal cord lipoma: A case report.

Neurochirurgie 2018 Dec 2;64(6):442-444. Epub 2018 Nov 2.

Department of neurosurgery and radiology, faculty of Medicine, UDL Sidi Bel Abbes, Algeria.

Introduction: Intramedullary spinal cord lipomas (IMSCL) are a rare entity, accounting for less than 1% of spinal tumors. Most cases are associated with lumbosacral dysraphism and occur predominantly in the pediatric population.

Material And Method: We report the case of an isolated bipolar lipoma, which was very large in the cervicodorsal region and small in the conus medularis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00283770183032
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http://dx.doi.org/10.1016/j.neuchi.2018.08.005DOI Listing
December 2018
13 Reads

A mini-open transspinous approach for resection of intramedullary spinal cavernous malformations.

J Clin Neurosci 2018 Dec 13;58:210-212. Epub 2018 Oct 13.

University of California San Francisco, Department of Neurological Surgery, San Francisco, CA, USA. Electronic address:

Background And Importance: Advances in minimally invasive (MIS) and mini-open surgical approaches have led to reductions in perioperative morbidity without compromising rates of resection of non-degenerative intradural spinal pathologies. Whether these approaches may be adapted for the surgical resection for intramedullary vascular malformations - such as cavernous malformations (CMs) - has yet to be reported. The authors describe a mini-open transspinous approach to resect a ruptured intramedullary CM of the conus medullaris. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09675868183082
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http://dx.doi.org/10.1016/j.jocn.2018.10.028DOI Listing
December 2018
21 Reads
1.320 Impact Factor

Natural Course of Myxopapillary Ependymoma: Unusual Case Report and Review of Literature.

World Neurosurg 2019 Jan 12;121:239-242. Epub 2018 Oct 12.

Craniospinal Surgery Center, Ankara, Turkey.

Background: Spinal cord ependymomas are the most frequent primary intramedullary tumors of the cord in middle age (40-60 years of age). Myxopapillary ependymomas are low-incidence tumors and occur in the cauda equina and conus medullaris. They are typically described as fleshy, sausage-shaped, vascular lesions. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750183232
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http://dx.doi.org/10.1016/j.wneu.2018.10.028DOI Listing
January 2019
21 Reads

3T proton MR Spectroscopy evaluation of spinal cord lesions.

Indian J Radiol Imaging 2018 Jul-Sep;28(3):285-295

Barnard Institute of Radiology, Madras Medical College, Chennai, Tamil Nadu, India.

Objective: The objective of this study was to evaluate intramedullary spinal cord lesions using magnetic resonance spectroscopy and correlate the results with histo-pathological examination (HPE).

Materials And Methods: Approval for this study was obtained from our institute ethical committee. , with a maximum age of 53 years and minimum age of 7 years. Read More

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http://www.ijri.org/text.asp?2018/28/3/285/242167
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http://dx.doi.org/10.4103/ijri.IJRI_122_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6176681PMC
October 2018
20 Reads

Intramedullary and Extramedullary Thoracic Spinal Lipomas Without Spinal Dysraphism: Clinical Presentation and Surgical Management.

World Neurosurg 2019 Jan 11;121:156-159. Epub 2018 Oct 11.

Department of Neurological Surgery, University of California, San Francisco, California, USA.

Background: Intradural intramedullary lipomas without dysraphism are rare tumors. Although they appear extramedullary on imaging, they invade into the intramedullary substance of the spinal cord. We present 2 cases and discuss their clinical presentation, radiologic findings, and surgical management. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.09.156DOI Listing
January 2019
4 Reads

Pediatric Spinal Ependymomas.

Med Sci Monit 2018 Oct 5;24:7072-7089. Epub 2018 Oct 5.

Department of Neurosurgery, Bezmialem Vakif University, Istanbul, Turkey.

BACKGROUND The aim of this study was to assess the clinical and radiological outcomes of surgical treatment for primary spinal ependymoma in children. MATERIAL AND METHODS Medical records of 46 primary spinal ependymoma patients who underwent surgery in BRSHH hospital during a 12-year period from 2004 to 2015 were retrospectively reviewed. All pediatric patients (patient age <18 years) were selected as the core sample used for this study. Read More

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https://www.medscimonit.com/abstract/index/idArt/910447
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http://dx.doi.org/10.12659/MSM.910447DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6186154PMC
October 2018
7 Reads

Acute Surgical Risk Profile of Intramedullary Spinal Cord Tumor Resection in Pediatric Patients: A Pediatric National Surgical Quality Improvement Program Analysis.

World Neurosurg 2019 Jan 26;121:e389-e397. Epub 2018 Sep 26.

Department of Neurosurgery, The University of Illinois at Chicago, Chicago, Illinois, USA. Electronic address:

Objective: The purpose of the present study was to characterize the acute (30-day) surgical risk profile of pediatric patients undergoing surgical resection of intramedullary spinal cord tumors (IMSCTs).

Methods: Preoperative factors were collected from the Pediatric American College of Surgeons National Surgical Quality Improvement Program database for patients identified by Current Procedural Terminology codes for laminectomy and International Classification of Diseases codes for IMSCTs from 2012 to 2016. The postoperative outcomes were compared by tumor location and type. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750183215
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http://dx.doi.org/10.1016/j.wneu.2018.09.113DOI Listing
January 2019
13 Reads
2.420 Impact Factor

Spinal Dermoid Cyst with Spontaneous Rupture into the Syrinx Cavity Alone.

World Neurosurg 2018 Oct 3;118:e395-e404. Epub 2018 Jul 3.

Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing; and China National Clinical Research Center for Neurological Diseases (NCRC-ND), Beijing, China. Electronic address:

Objective: Spinal dermoid cysts are uncommon tumors, and their spontaneous rupture into the syrinx cavity alone is extremely rare. The treatment strategy for this condition has not been described.

Methods: We report 4 patients with lumbar spinal dermoid cysts and spontaneous rupture. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.06.201DOI Listing
October 2018
6 Reads

Spinal cord astrocytomas: progresses in experimental and clinical investigations for developing recovery neurobiology-based novel therapies.

Exp Neurol 2019 01 21;311:135-147. Epub 2018 Sep 21.

Departments of Physical Medicine & Rehabilitation and Neurosurgery, Harvard Medical School, Spaulding Rehabilitation Hospital and Brigham and Women's Hospital, Division of Spinal Cord Injury Research, VA Boston Healthcare System, Boston, MA, USA.

Spinal cord astrocytomas (SCAs) have discernibly unique signatures in regards to epidemiology, clinical oncological features, genetic markers, pathophysiology, and research and therapeutic challenges. Overall, there are presently very limited clinical management options for high grade SCAs despite progresses made in validating key molecular markers and standardizing tumor classification. The endeavors were aimed to improve diagnosis, therapy design and prognosis assessment, as well as to define more effective oncolytic targets. Read More

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http://dx.doi.org/10.1016/j.expneurol.2018.09.010DOI Listing
January 2019
33 Reads

A Long-Term Control of Intramedullary Thoracic Spinal Cord Metastasis from Small Cell Lung Cancer.

Acta Medica (Hradec Kralove) 2018;61(2):57-59

Division of Respiratory Medicine, Mito Medical Center, University of Tsukuba.

Radiotherapy with systemic corticosteroid therapy has been used to treat intramedullary spinal cord metastasis (ISCM), but recovery of function and long-term survival of these patients has been rarely observed. We report herein a small cell lung cancer (SCLC) patient with recurrent thoracic ISCM, who was successfully treated with radiotherapy and systemic corticosteroid therapy. A 70-year-old man, who was diagnosed as having SCLC seven months previously, developed thoracic ISCM. Read More

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http://dx.doi.org/10.14712/18059694.2018.52DOI Listing
December 2018
3 Reads

Cavernoma of the cauda equina.

Surg Neurol Int 2018 28;9:174. Epub 2018 Aug 28.

Department of Neurosurgery, KAT General Hospital of Attica, Kifisia 145 61, Greece.

Background: Cavernomas are benign malformations of the vasculature. In the central nervous system, they are mostly located supratentorially. However, in adults, cavernomas also comprise about 3% of all subdural spinal cord tumors. Read More

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http://www.surgicalneurologyint.com/text.asp?2018/9/1/174/24
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http://dx.doi.org/10.4103/sni.sni_212_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122280PMC
August 2018
17 Reads

Long-term outcome and prognostic factors of intramedullary spinal hemangioblastomas.

Neurosurg Rev 2018 Aug 31. Epub 2018 Aug 31.

Sri Chitra Tirunal Institute for Medical Science and Technology, Medical college post, Trivandrum, Kerala, 691011, India.

Spinal hemangioblastomas constitute 1.6-5.8% of all spinal cord tumors. Read More

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http://dx.doi.org/10.1007/s10143-018-1025-2DOI Listing
August 2018
3 Reads