2,311 results match your criteria Intramedullary Spinal Cord Tumors


Unusual radiological and histological presentation of a diffuse leptomeningeal glioneuronal tumor (DLGNT) in a 13-year-old girl.

Childs Nerv Syst 2019 Feb 15. Epub 2019 Feb 15.

Department of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, Los Angeles, CA, 90027, USA.

Diffuse leptomeningeal glioneuronal tumors (DLGNTs) are newly recognized as an entity in the 2016 revision of the WHO Classification of tumors of the central nervous system. They typically present as diffuse leptomeningeal infiltrates along the neuraxis with focal and superficial involvement of the parenchyma. Here, we report a DLGNT with unusual radiological and histological features. Read More

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http://dx.doi.org/10.1007/s00381-019-04074-7DOI Listing
February 2019
1 Read

Stratification of Grade of Spinal Cord Non-Ependymal Gliomas by Magnetic Resonance Imaging.

World Neurosurg 2019 Feb 8. Epub 2019 Feb 8.

Department of Radiology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, China. Electronic address:

Objective: The purpose of this study was to demonstrate the usefulness of conventional magnetic resonance imaging (MRI) in stratification of spinal cord non-ependymal gliomas.

Methods: Forty-one patients (mean age, 29.9 ± 16. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.01.205DOI Listing
February 2019
1 Read
2.417 Impact Factor

Risk factor analysis of progressive spinal deformity after resection of intramedullary spinal cord tumors in patients who underwent laminoplasty: a report of 105 consecutive cases.

J Neurosurg Spine 2019 Feb 8:1-9. Epub 2019 Feb 8.

Departments of1Neurosurgery and.

OBJECTIVELaminoplasty has been used in recent years as an alternative approach to laminectomy for preventing spinal deformity after resection of intramedullary spinal cord tumors (IMSCTs). However, controversies exist with regard to its real role in maintaining postoperative spinal alignment. The purpose of this study was to examine the incidence of progressive spinal deformity in patients who underwent laminoplasty for resection of IMSCT and identify risk factors for progressive spinal deformity. Read More

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http://dx.doi.org/10.3171/2018.10.SPINE18110DOI Listing
February 2019

Xenografting for disease modeling of intramedullary spinal cord tumors: a systematic review.

Spinal Cord 2019 Feb 1. Epub 2019 Feb 1.

Department of Neurosurgery, University Hospital Essen, Essen, Germany.

Study Design: Systematic review.

Objectives: The overall incidence of intramedullary spinal cord tumors (IMSCT) remains low and clinical trials or standardized treatment strategies are missing. Therefore, multiple animal-based xenograft models (AXM) have been developed to foster preclinical research efforts on IMSCT. Read More

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http://www.nature.com/articles/s41393-019-0248-6
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http://dx.doi.org/10.1038/s41393-019-0248-6DOI Listing
February 2019
2 Reads

Intra-operative neuromonitoring in patients with intramedullary spinal cord tumor: a systematic review, meta-analysis, and case series.

World Neurosurg 2019 Jan 16. Epub 2019 Jan 16.

Department of Neurosurgery, Erasmus University Medical Centre, Rotterdam, The Netherlands. Electronic address:

Background: Intramedullary spinal cord tumors (IMSCT) comprise the least common types of spinal neoplasms; surgery is mostly conducted with intraoperative neuromonitoring (IONM). However, although IONM is widely used to prevent neurological damage and many single-center studies have been published, the added value, in terms of overall sensitivity and specificity, of different monitoring techniques used in IMSCT surgery, remains to be clearly defined.

Object: Summarize and review the published evidence on the use of IONM in IMSCT surgery, including our own case series (n=75 patients). Read More

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http://dx.doi.org/10.1016/j.wneu.2019.01.007DOI Listing
January 2019

Intramedullary spinal cord metastases: an institutional review of survival and outcomes.

J Neurooncol 2019 Jan 17. Epub 2019 Jan 17.

Mayo Clinic Neuro-Informatics Laboratory, Department of Neurologic Surgery, Mayo Clinic, Rochester, MN, USA.

Introduction: Intramedullary spinal cord metastases (ISCMs) are rare lesions affecting the spinal cord in patients with disseminated malignancy. Today, due to increased survival, these lesions are more frequently diagnosed. Literature on survival and neurologic outcomes is sparse. Read More

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http://dx.doi.org/10.1007/s11060-019-03105-2DOI Listing
January 2019
1 Read

Lumbar Intramedullary Epidermoid Following Repair of Sacral Myelomeningocele and Tethered Cord: A Case Report With a Review of the Relevant Literature and Operative Nuances.

Neurospine 2018 Sep 4. Epub 2018 Sep 4.

Department of Neurosurgery, Kovai Medical Center and Hospital, Coimbatore, India.

Epidermoid cysts of the spine are rare tumors. While majority of them occur spontaneously, very few occur following a previous surgery for spinal dysraphism. Such tumors tend to occur at the site of previous surgery. Read More

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http://dx.doi.org/10.14245/ns.1836152.076DOI Listing
September 2018
4 Reads

Spinal dural tenting sutures in intradural tumor surgery: A technical insight.

J Clin Neurosci 2019 Mar 28;61:322-323. Epub 2018 Oct 28.

A.O.U. "Sant'Andrea", Neurosurgery Division, Sapienza University, Rome, NESMOS Department, Via di Grottarossa, 1035-1039, 00189 Roma, Italy.

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http://dx.doi.org/10.1016/j.jocn.2018.10.085DOI Listing

MR imaging features of spinal pilocytic astrocytoma.

BMC Med Imaging 2019 Jan 14;19(1). Epub 2019 Jan 14.

Department of Radiology, Huashan Hospital, Fudan University, 12 Middle Wulumuqi Road, Jingan District, Shanghai, China.

Background: The purpose of this retrospective review is to determine the MR imaging features of pilocytic astrocytoma (PA) in the spinal cord to help neuroradiologists preoperatively differentiate PA from other intramedullary tumors.

Methods: Neuro-oncology database review revealed 13 consecutive patients with a pathological spinal PA diagnosis and availability of preoperative MR imaging. Three patients had preoperative diffusion-weighted MR imaging. Read More

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http://dx.doi.org/10.1186/s12880-018-0296-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332544PMC
January 2019
1 Read

classification of spinal cord tumors using autofluorescence spectroscopy and immunohistochemical indexes.

Biomed Opt Express 2018 Sep 21;9(9):4401-4412. Epub 2018 Aug 21.

Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing 100084, China.

Spinal cord tumors are complicated and infrequent, which poses a major challenge to surgeons during neurosurgery. Currently, the intraoperative identification of the tissues' pathological properties is usually difficult for surgeons. This issue influences the decision-making in treatment planning. Read More

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http://dx.doi.org/10.1364/BOE.9.004401DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157786PMC
September 2018
1 Read

Microsurgical Resection of Low-Grade Spinal Cord Astrocytoma: 2-Dimensional Operative Video.

Oper Neurosurg (Hagerstown) 2018 Dec 19. Epub 2018 Dec 19.

Semmes Murphey Neurologic & Spine Institute, Memphis, Tennessee.

This video demonstrates microsurgical resection of low-grade (Grade I) thoracic spinal cord astrocytoma. Astrocytomas are the most common pediatric intramedullary tumors and occur secondary to ependymomas in adults.1,2 The treatment goal should be radical gross total resection while preserving neurological function with intraoperative neuromonitoring. Read More

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https://academic.oup.com/ons/advance-article/doi/10.1093/ons
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http://dx.doi.org/10.1093/ons/opy386DOI Listing
December 2018
5 Reads

Primary spinal primitive neuroectodermal tumor: A single center series with literature review.

J Spinal Cord Med 2018 Dec 18:1-9. Epub 2018 Dec 18.

a Department of Neurosurgery , Beijing Tiantan Hospital affiliated to Capital Medical University , Beijing , People's Republic of China.

Context: Primary spinal primitive neuroectodermal tumor (PNET) of the central nervous system has a low incidence. The intraspinal case is very rare. Around 30 cases have been reported so far. Read More

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https://www.tandfonline.com/doi/full/10.1080/10790268.2018.1
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http://dx.doi.org/10.1080/10790268.2018.1547862DOI Listing
December 2018
11 Reads
1.878 Impact Factor

[Intramedullary spinal cord tumour as differential diagnosis to bilateral muscle weakness].

Ugeskr Laeger 2018 Dec;180(50)

Intramedullary spinal cord tumours (IMSCT) are rare neoplasms, which can potentially lead to severe neurologic deficits. In this case report, an 83-year-old man presented with rapidly progressive bilateral muscle weakness developed within few weeks. MRI revealed a spinal cord tumour at the C7/Th1 vertebral level. Read More

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December 2018

Microneurosurgical Removal of a Cervical Intramedullary Tumor Via Hemilaminoplasty: 3-Dimensional Operative Video.

Oper Neurosurg (Hagerstown) 2018 Dec 12. Epub 2018 Dec 12.

Department of Neurosurgery, Yeditepe University School of Medicine, Istanbul, Turkey.

Intramedullary tumors of the spinal cord are rare and account for 2% to 8.5% of all central nervous system tumors. In adults, ependymomas are the most common intramedullary tumors. Read More

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http://dx.doi.org/10.1093/ons/opy297DOI Listing
December 2018
1 Read

Intramedullary spinal tumor-like lesions.

Acta Radiol 2018 Dec 11:284185118809540. Epub 2018 Dec 11.

4 Department of Diagnostic Imaging, Institute of Mother and Child, Warsaw, Poland.

The development of magnetic resonance imaging (MRI) has led to an increasingly frequent detection of changes in the spinal cord. The most common intramedullary lesions are: demyelinating; vascular; inflammatory; infectious; and congenital, largely called tumor-like lesions. Spinal cord tumors are relatively rare, as compared with brain tumors. Read More

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http://journals.sagepub.com/doi/10.1177/0284185118809540
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http://dx.doi.org/10.1177/0284185118809540DOI Listing
December 2018
3 Reads

Intraoperative neurophysiological monitoring for intradural extramedullary spinal tumors: predictive value and relevance of D-wave amplitude on surgical outcome during a 10-year experience.

J Neurosurg Spine 2018 Nov 1:1-9. Epub 2018 Nov 1.

4Department of Neurosurgery, Humanitas Research Hospital and University, Milan, Italy.

OBJECTIVEThe purpose of this study was to evaluate the technical feasibility, accuracy, and relevance on surgical outcome of D-wave monitoring combined with somatosensory evoked potentials (SSEPs) and motor evoked potentials (MEPs) during resection of intradural extramedullary (IDEM) spinal tumors.METHODSClinical and intraoperative neurophysiological monitoring (IONM) data obtained in 108 consecutive patients who underwent surgery for IDEM tumors at the Institute for Scientific and Care Research "ASMN" of Reggio Emilia, Italy, were prospectively entered into a database and retrospectively analyzed. The IONM included SSEPs, MEPs, and-whenever possible-D-waves. Read More

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https://thejns.org/view/journals/j-neurosurg-spine/aop/artic
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http://dx.doi.org/10.3171/2018.7.SPINE18278DOI Listing
November 2018
6 Reads

Intramedullary spinal cord ependymoma and astrocytoma: intraoperative frozen-section diagnosis, extent of resection, and outcomes.

Authors:

J Neurosurg Spine 2018 Oct 1:1-7. Epub 2018 Oct 1.

OBJECTIVEThe intraoperative differentiation of ependymomas from astrocytomas is important because neurosurgical strategies differ between these two tumor groups. Previous studies have reported that the diagnostic accuracy of intraoperative frozen sections of intracranial central nervous system (CNS) tumors is higher than 83%-97%, whereas that for spinal intramedullary tumors remains unknown. Herein, authors tested the hypothesis that intraoperative frozen-section diagnosis is the gold standard for a differential diagnosis of intramedullary spinal cord tumors. Read More

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http://dx.doi.org/10.3171/2018.7.SPINE18230DOI Listing
October 2018
2 Reads

A case report of an intramedullary cervical teratoma in an adult patient with cervical spondylotic radiculopathy.

Neurocirugia (Astur) 2018 Oct 25. Epub 2018 Oct 25.

Servicio de Neurocirugía, Módulo de Columna, Hospital Regional 1° de Octubre, ISSSTE, Mexico City, Mexico.

Spinal cord teratomas are rare. There are few reports of teratomas affecting the cervical spine and their association with spondylotic radiculopathy has not been described. A 59-year-old woman with history of fecal incontinence attended with cervical radicular pain radiating to upper limbs. Read More

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http://dx.doi.org/10.1016/j.neucir.2018.09.001DOI Listing
October 2018
2 Reads

Intramedullary Spinal Cord Lipoma Mimicking a Late Subacute Hematoma.

Asian J Neurosurg 2018 Oct-Dec;13(4):1282-1284

Department of Neurosurgery, University Hospital Center Zagreb, University of Zagreb, School of Medicine, Zagreb, Croatia.

Spinal cord lipomas are rare and benign tumors which may cause progressive neurological deficits due to their local expansion. We present the case of a 59-year-old male patient with severe lumbosacral pain and slowly progressive paresis of the right leg, misdiagnosed with degenerative spine disease. Repeated magnetic resonance (MR) T1-weighted images of the thoracic spine suggested a subacute intramedullary hematoma. Read More

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http://dx.doi.org/10.4103/ajns.AJNS_112_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6208254PMC
November 2018
11 Reads

Progressive Feeding Intolerance Secondary to a Congenital Spinal Teratoma in a Four-week-old Female.

Cureus 2018 Sep 11;10(9):e3281. Epub 2018 Sep 11.

Pediatrics, University of Illinois College of Medicine At Peoria, Peoria, USA.

A poorly feeding neonate presents the clinician with a diagnostic challenge. Feeding difficulties and irritability may be due to sepsis, congenital heart disease, inborn errors of metabolism, non-accidental head trauma, as well as a vast variety of other pathologies. Teratomas are rare pediatric tumors that can occasionally present in the immediate neonatal period and can manifest in the infant's central nervous system (CNS) with non-specific symptoms of poor feeding, lethargy, and somnolence. Read More

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https://www.cureus.com/articles/13804-progressive-feeding-in
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http://dx.doi.org/10.7759/cureus.3281DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6235640PMC
September 2018
9 Reads

Prophylactic enlargement of the thecal sac volume by spinal expansion duroplasty in patients with unresectable malignant intramedullary tumors and metastases prior to radiotherapy.

Neurosurg Rev 2018 Nov 14. Epub 2018 Nov 14.

Department of Neurosurgery, Medical Center, Georg August University of Göttingen, Göttingen, Germany.

Unresectable malignant intramedullary tumors and metastases usually require radiotherapy which intensifies spinal cord edema and might result in neurological decline. Spinal expansion duroplasty before radiotherapy enlarges the intrathecal volume and might thus prevent neurological deficits. The study aims to evaluate the clinical course of patients undergoing expansion duroplasty. Read More

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http://dx.doi.org/10.1007/s10143-018-1051-0DOI Listing
November 2018

Intramedullary schwannoma of conus medullaris: rare site for a common tumor with review of literature.

Spinal Cord Ser Cases 2018 6;4:99. Epub 2018 Nov 6.

3Department of Radiology, Institute of Human Behaviour and Allied Sciences, Delhi, India.

Introduction: Schwannomas at an intramedullary location constitute only 0.3% of primary spinal tumors. Those in the conus are extremely rare, especially in the absence of neurofibromatosis, with only 12 cases reported in the literature so far, excluding the present case. Read More

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http://dx.doi.org/10.1038/s41394-018-0134-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219485PMC
November 2018
1 Read

Giant bipolar intramedullary nondysraphic spinal cord lipoma: A case report.

Neurochirurgie 2018 Dec 2;64(6):442-444. Epub 2018 Nov 2.

Department of neurosurgery and radiology, faculty of Medicine, UDL Sidi Bel Abbes, Algeria.

Introduction: Intramedullary spinal cord lipomas (IMSCL) are a rare entity, accounting for less than 1% of spinal tumors. Most cases are associated with lumbosacral dysraphism and occur predominantly in the pediatric population.

Material And Method: We report the case of an isolated bipolar lipoma, which was very large in the cervicodorsal region and small in the conus medularis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00283770183032
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http://dx.doi.org/10.1016/j.neuchi.2018.08.005DOI Listing
December 2018
9 Reads

A mini-open transspinous approach for resection of intramedullary spinal cavernous malformations.

J Clin Neurosci 2018 Dec 13;58:210-212. Epub 2018 Oct 13.

University of California San Francisco, Department of Neurological Surgery, San Francisco, CA, USA. Electronic address:

Background And Importance: Advances in minimally invasive (MIS) and mini-open surgical approaches have led to reductions in perioperative morbidity without compromising rates of resection of non-degenerative intradural spinal pathologies. Whether these approaches may be adapted for the surgical resection for intramedullary vascular malformations - such as cavernous malformations (CMs) - has yet to be reported. The authors describe a mini-open transspinous approach to resect a ruptured intramedullary CM of the conus medullaris. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09675868183082
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http://dx.doi.org/10.1016/j.jocn.2018.10.028DOI Listing
December 2018
12 Reads
1.320 Impact Factor

Natural Course of Myxopapillary Ependymoma: Unusual Case Report and Review of Literature.

World Neurosurg 2019 Jan 12;121:239-242. Epub 2018 Oct 12.

Craniospinal Surgery Center, Ankara, Turkey.

Background: Spinal cord ependymomas are the most frequent primary intramedullary tumors of the cord in middle age (40-60 years of age). Myxopapillary ependymomas are low-incidence tumors and occur in the cauda equina and conus medullaris. They are typically described as fleshy, sausage-shaped, vascular lesions. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750183232
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http://dx.doi.org/10.1016/j.wneu.2018.10.028DOI Listing
January 2019
11 Reads

3T proton MR Spectroscopy evaluation of spinal cord lesions.

Indian J Radiol Imaging 2018 Jul-Sep;28(3):285-295

Barnard Institute of Radiology, Madras Medical College, Chennai, Tamil Nadu, India.

Objective: The objective of this study was to evaluate intramedullary spinal cord lesions using magnetic resonance spectroscopy and correlate the results with histo-pathological examination (HPE).

Materials And Methods: Approval for this study was obtained from our institute ethical committee. , with a maximum age of 53 years and minimum age of 7 years. Read More

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http://www.ijri.org/text.asp?2018/28/3/285/242167
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http://dx.doi.org/10.4103/ijri.IJRI_122_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6176681PMC
October 2018
17 Reads

Intramedullary and Extramedullary Thoracic Spinal Lipomas Without Spinal Dysraphism: Clinical Presentation and Surgical Management.

World Neurosurg 2019 Jan 11;121:156-159. Epub 2018 Oct 11.

Department of Neurological Surgery, University of California, San Francisco, California, USA.

Background: Intradural intramedullary lipomas without dysraphism are rare tumors. Although they appear extramedullary on imaging, they invade into the intramedullary substance of the spinal cord. We present 2 cases and discuss their clinical presentation, radiologic findings, and surgical management. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.09.156DOI Listing
January 2019
3 Reads

Pediatric Spinal Ependymomas.

Med Sci Monit 2018 Oct 5;24:7072-7089. Epub 2018 Oct 5.

Department of Neurosurgery, Bezmialem Vakif University, Istanbul, Turkey.

BACKGROUND The aim of this study was to assess the clinical and radiological outcomes of surgical treatment for primary spinal ependymoma in children. MATERIAL AND METHODS Medical records of 46 primary spinal ependymoma patients who underwent surgery in BRSHH hospital during a 12-year period from 2004 to 2015 were retrospectively reviewed. All pediatric patients (patient age <18 years) were selected as the core sample used for this study. Read More

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https://www.medscimonit.com/abstract/index/idArt/910447
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http://dx.doi.org/10.12659/MSM.910447DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6186154PMC
October 2018
5 Reads

Acute Surgical Risk Profile of Intramedullary Spinal Cord Tumor Resection in Pediatric Patients: A Pediatric National Surgical Quality Improvement Program Analysis.

World Neurosurg 2019 Jan 26;121:e389-e397. Epub 2018 Sep 26.

Department of Neurosurgery, The University of Illinois at Chicago, Chicago, Illinois, USA. Electronic address:

Objective: The purpose of the present study was to characterize the acute (30-day) surgical risk profile of pediatric patients undergoing surgical resection of intramedullary spinal cord tumors (IMSCTs).

Methods: Preoperative factors were collected from the Pediatric American College of Surgeons National Surgical Quality Improvement Program database for patients identified by Current Procedural Terminology codes for laminectomy and International Classification of Diseases codes for IMSCTs from 2012 to 2016. The postoperative outcomes were compared by tumor location and type. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750183215
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http://dx.doi.org/10.1016/j.wneu.2018.09.113DOI Listing
January 2019
12 Reads
2.420 Impact Factor

Spinal Dermoid Cyst with Spontaneous Rupture into the Syrinx Cavity Alone.

World Neurosurg 2018 Oct 3;118:e395-e404. Epub 2018 Jul 3.

Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing; and China National Clinical Research Center for Neurological Diseases (NCRC-ND), Beijing, China. Electronic address:

Objective: Spinal dermoid cysts are uncommon tumors, and their spontaneous rupture into the syrinx cavity alone is extremely rare. The treatment strategy for this condition has not been described.

Methods: We report 4 patients with lumbar spinal dermoid cysts and spontaneous rupture. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.06.201DOI Listing
October 2018
3 Reads

A Long-Term Control of Intramedullary Thoracic Spinal Cord Metastasis from Small Cell Lung Cancer.

Acta Medica (Hradec Kralove) 2018;61(2):57-59

Division of Respiratory Medicine, Mito Medical Center, University of Tsukuba.

Radiotherapy with systemic corticosteroid therapy has been used to treat intramedullary spinal cord metastasis (ISCM), but recovery of function and long-term survival of these patients has been rarely observed. We report herein a small cell lung cancer (SCLC) patient with recurrent thoracic ISCM, who was successfully treated with radiotherapy and systemic corticosteroid therapy. A 70-year-old man, who was diagnosed as having SCLC seven months previously, developed thoracic ISCM. Read More

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http://dx.doi.org/10.14712/18059694.2018.52DOI Listing
December 2018
1 Read

Cavernoma of the cauda equina.

Surg Neurol Int 2018 28;9:174. Epub 2018 Aug 28.

Department of Neurosurgery, KAT General Hospital of Attica, Kifisia 145 61, Greece.

Background: Cavernomas are benign malformations of the vasculature. In the central nervous system, they are mostly located supratentorially. However, in adults, cavernomas also comprise about 3% of all subdural spinal cord tumors. Read More

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http://www.surgicalneurologyint.com/text.asp?2018/9/1/174/24
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http://dx.doi.org/10.4103/sni.sni_212_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122280PMC
August 2018
11 Reads

Long-term outcome and prognostic factors of intramedullary spinal hemangioblastomas.

Neurosurg Rev 2018 Aug 31. Epub 2018 Aug 31.

Sri Chitra Tirunal Institute for Medical Science and Technology, Medical college post, Trivandrum, Kerala, 691011, India.

Spinal hemangioblastomas constitute 1.6-5.8% of all spinal cord tumors. Read More

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http://dx.doi.org/10.1007/s10143-018-1025-2DOI Listing
August 2018
1 Read

Survival outcomes and prognostic factors of patients with intramedullary Grade II ependymomas after surgical treatments.

J Clin Neurosci 2018 Nov 23;57:136-142. Epub 2018 Aug 23.

Department of Orthopedics, Xuanwu Hospital Capital Medical University, China; National Clinical Research Center for Geriatric Diseases, China; Capital Medical University, China.

This study evaluated survival outcomes of patients with intramedullary Grade II ependymomas and identify prognostic factors. Electronic searches of PubMed, EMBASE, OVID, the Cochrane Central Register of Controlled Trials were performed to identify trials according to the Cochrane Collaboration guidelines. The objects were intramedullary Grade II ependymoma according to 2007 WHO classification. Read More

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http://dx.doi.org/10.1016/j.jocn.2018.08.001DOI Listing
November 2018
5 Reads

Analysis of Multimodal Intraoperative Monitoring During Intramedullary Spinal Ependymoma Surgery.

World Neurosurg 2018 Dec 8;120:e169-e180. Epub 2018 Aug 8.

Department of Neurosurgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.

Objective: To evaluate the validity of intraoperative somatosensory-evoked potential (SSEP) and motor-evoked potential (MEP) monitoring according to 2 different warning criteria during 6 months from intramedullary spinal ependymoma surgery.

Methods: Twenty-six patients who underwent intramedullary spinal ependymoma surgery with intraoperative monitoring from January 2010 to June 2017 were retrospectively analyzed. We examined the sensitivity, specificity, positive predictable value, negative predictable value, and diagnostic odds ratio of SSEP and MEP monitoring for each extremity according to 2 warning criteria: 50% decline and all-or-none. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.07.267DOI Listing
December 2018
2 Reads

5-Aminolevulinic acid fluorescence-guided surgery for spinal cord melanoma metastasis: a technical note.

Acta Neurochir (Wien) 2018 Oct 9;160(10):1905-1908. Epub 2018 Aug 9.

Universidad Nacional de Asunción, San Lorenzo, Paraguay.

Background: According to our research, just few studies described 5-Aminolevulinic acid (5-ALA) use for spinal injuries resection. 5-ALA is known to be especially useful in certain spinal tumor entities such as meningiomas, ependymomas, hemangiopericytomas, and metastasis of central nervous system primary tumors. In contrast, 5-ALA has limited value in other histopathological tumoral entities, as neurinomas and carcinoma metastasis. Read More

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http://dx.doi.org/10.1007/s00701-018-3645-2DOI Listing
October 2018
2 Reads

Magnetic Drug Targeting: A Novel Treatment for Intramedullary Spinal Cord Tumors.

Sci Rep 2018 Jul 30;8(1):11417. Epub 2018 Jul 30.

Department of Neurosurgery, University of Illinois at Chicago, Chicago, IL, 60612, United States.

Most applications of nanotechnology in cancer have focused on systemic delivery of cytotoxic drugs. Systemic delivery relies on accumulation of nanoparticles in a target tissue through enhanced permeability of leaky vasculature and retention effect of poor lymphatic drainage to increase the therapeutic index. Systemic delivery is limited, however, by toxicity and difficulty crossing natural obstructions, like the blood spine barrier. Read More

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http://dx.doi.org/10.1038/s41598-018-29736-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6065319PMC
July 2018
2 Reads

Application of Multimodal Image Fusion to Precisely Localize Small Intramedullary Spinal Cord Tumors.

World Neurosurg 2018 Oct 20;118:246-249. Epub 2018 Jul 20.

Department of Neurosurgery, Beijing Tsinghua Changgung Hospital, Tsinghua University, Beijing, China.

Objective: We sought to study the application of precise intraoperative localization of small intramedullary spinal cord tumors.

Methods: From November 2015 to August 2017, 5 patients with small intramedullary spinal cord tumors were arranged in this group. By using the O-arm image system, we acquired the intraoperative computed tomography images of all patients and sent them to the Stealth navigation system. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.07.034DOI Listing
October 2018
7 Reads

Surgical outcomes of pediatric spinal cord astrocytomas: systematic review and meta-analysis.

J Neurosurg Pediatr 2018 Oct 20;22(4):404-410. Epub 2018 Jul 20.

Departments of 1 Neurosurgery and.

Objective: Pediatric spinal astrocytomas are rare spinal lesions that pose unique management challenges. Therapeutic options include gross-total resection (GTR), subtotal resection (STR), and adjuvant chemotherapy or radiation therapy. With no randomized controlled trials, the optimal management approach for children with spinal astrocytomas remains unclear. Read More

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http://dx.doi.org/10.3171/2018.4.PEDS17587DOI Listing
October 2018
3 Reads

Surgical Treatment of Intramedullary Spinal Metastasis in Medulloblastoma: Case Report and Review of the Literature.

World Neurosurg 2018 Oct 7;118:42-46. Epub 2018 Jul 7.

Department of Neurosurgery, Nicklaus Children's Hospital, Miami, Florida, USA; Department of Neurosurgery, University of Miami Miller School of Medicine, Miami, Florida, USA.

Background: Medulloblastomas are common childhood central nervous system tumors that are prone to leptomeningeal spread. Intramedullary dissemination is rare with very few case reports existing in the available literature.

Case Description: The authors here present a case of a 14-year-old boy with Li-Fraumeni syndrome and medulloblastoma who underwent surgical resection of spinal intramedullary spread. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.06.250DOI Listing
October 2018
3 Reads

Surgical Outcomes of Spinal Cord Intramedullary Cavernous Malformation: A Retrospective Study of 83 Patients in a Single Center over a 12-Year Period.

World Neurosurg 2018 Oct 26;118:e105-e114. Epub 2018 Jun 26.

Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China. Electronic address:

Objective: Spinal cord intramedullary cavernous malformation (SICM) is kind of rare vascular disease, and the therapeutic strategy is still under debate. The purpose of this article is to analyze outcome of SICM surgical resection and to find the possible factors indicating a better outcome.

Methods: A retrospective analysis of 83 patients with SICM in a single center from 2005 to 2017 was performed. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.06.134DOI Listing
October 2018
10 Reads

Primary Intramedullary Spinal Cord Lymphoma Presenting as a Cervical Ring-Enhancing Lesion in an AIDS Patient.

Open Forum Infect Dis 2018 Jun 4;5(6):ofy128. Epub 2018 Jun 4.

Division of Infectious Diseases, Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida.

Primary intramedullary spinal cord lymphoma (PISCL) is rare and constitutes only 1% of central nervous system lymphomas. We report a case of PISCL in a 37-year-old man with advanced AIDS. To our knowledge, only 4 cases of PISCL in the setting of HIV/AIDS have been reported in the literature. Read More

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http://dx.doi.org/10.1093/ofid/ofy128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6014371PMC
June 2018
7 Reads

Location, length, and enhancement: systematic approach to differentiating intramedullary spinal cord lesions.

Insights Imaging 2018 Aug 12;9(4):511-526. Epub 2018 Jun 12.

Department of Imaging Sciences, University of Rochester Medical Center, 601 Elmwood Avenue, P.O. Box 648, Rochester, NY, 14642, USA.

Purpose: Intramedullary spinal cord abnormalities are often challenging to diagnose. Spinal cord biopsy is a high-risk procedure with the potential to cause permanent neurological injury. Magnetic resonance imaging is the modality of choice for diagnosis and preoperative assessment of patients with spinal cord abnormalities. Read More

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http://dx.doi.org/10.1007/s13244-018-0608-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6108975PMC
August 2018
8 Reads

Treatment outcomes of 17 patients with atypical spinal meningioma, including 4 with metastases: a retrospective observational study.

Spine J 2019 Feb 13;19(2):276-284. Epub 2018 Jun 13.

Department of Neurosurgery, Spine and Spinal Cord Institute, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea. Electronic address:

Background Context: Because of the scarcity of atypical spinal meningioma, there is a lack of research on this type of tumor or its associated metastases.

Purpose: The aim of this study was to investigate the biological behavior of atypical spinal meningioma and identify its prognostic factors by reviewing surgical and clinical outcomes of patients with these tumors.

Study Design: A retrospective chart review was performed. Read More

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http://dx.doi.org/10.1016/j.spinee.2018.06.006DOI Listing
February 2019
17 Reads

Extensive Cranial Nerves Involvement in Neurofibromatosis: A Rare Presentation.

J Pediatr Neurosci 2018 Jan-Mar;13(1):74-77

Department of Neurology, Institute of Human Behaviour and Allied Sciences (IHBAS), New Delhi, India.

Neurofibromatosis type 2 is a rare neurocutaneous syndrome characterized by the development of multiple nervous system tumors. This disorder is also called multiple inherited schwannomas, meningiomas, and ependymomas syndrome. In this report, we discuss the clinical and magnetic resonance imaging findings in a 17-year-old patient with neurofibromatosis type 2, who had extensive cranial nerves involvement (3rd-12th cranial nerves) along with spinal involvement. Read More

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http://dx.doi.org/10.4103/JPN.JPN_32_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5982496PMC
June 2018
6 Reads

Merkel cell carcinoma with intramedullary spinal cord metastasis: a very rare clinical finding.

Clin Case Rep 2018 Jun 6;6(6):1181-1182. Epub 2018 Apr 6.

Department of Internal Medicine Hurley Medical Center Michigan State University One Hurley Plaza Flint Michigan 48503.

This clinical image teaches readers that a rare finding such as intramedullary spinal metastasis could exist even in the rarest tumors. It adds to the literature how it was managed. It also might reflect the improvement of our cancer treatment allowing us to follow patients longer to find those rare findings in rare tumors. Read More

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http://dx.doi.org/10.1002/ccr3.1516DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5985991PMC

Outcome predictors in the management of intramedullary classic ependymoma: An integrative survival analysis.

Medicine (Baltimore) 2018 Jun;97(23):e10870

Department of Neurosurgery, Fujian Medical University Union Hospital, Fuzhou, Fujian, China.

This is a retrospective study.The aim of this study was to illustrate the survival outcomes of patients with classic ependymoma (CE) and identify potential prognostic factors.CE is the most common category of spinal ependymomas, but few published studies have discussed predictors of the survival outcome. Read More

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http://dx.doi.org/10.1097/MD.0000000000010870DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5999504PMC
June 2018
13 Reads

Pediatric intramedullary spinal cord tumor outcomes using the WeeFIM scale.

Childs Nerv Syst 2018 Sep 25;34(9):1753-1758. Epub 2018 May 25.

Department of Neurosurgery, Division of Pediatric Neurosurgery, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, OH, USA.

Purpose: The Functional Independence Measure for children (WeeFIM) is a user-friendly functional outcomes tool that has been validated across other traditional functional scales. Historically, the significant neurologic and functional deficits of intramedullary spinal cord tumors (IMSCTs) have been monitored by coarse or overbearing functional outcomes tools that make it difficult to measure the slow improvement/decline seen in these patients. This study is the first to report WeeFIM outcomes on a series of IMSCTs with emphasis on an aggressive surgical strategy. Read More

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http://dx.doi.org/10.1007/s00381-018-3831-9DOI Listing
September 2018
2 Reads

Impact of surgery and radiation therapy on spinal high-grade gliomas: a population-based study.

J Neurooncol 2018 Sep 23;139(3):609-616. Epub 2018 May 23.

Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Introduction: Spinal high-grade gliomas (S-HGGs) is an extremely rare entity in the literature, with only sporadic cases reported. We aim to characterize prognostic factors for post-treatment survival using the SEER database.

Methods: We examined all patients with gliomas located in the spinal cord. Read More

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http://dx.doi.org/10.1007/s11060-018-2904-7DOI Listing
September 2018
1 Read
3.070 Impact Factor

[Spinal cord epidermoid cysts].

Zh Vopr Neirokhir Im N N Burdenko 2018 ;82(2):39-47

Burdenko Neurosurgical Institute, 4-ya Tverskaya-Yamskaya Str., 16, Moscow, Russia, 125047.

The article describes in detail a large modern clinical series of patients operated on for spinal cord epidermoid cysts.

Aim: the study aim was to comprehensively investigate the epidemiological and clinical peculiarities of spinal cord epidermoid cysts and evaluate immediate and long-term results of their surgical treatment.

Material And Methods: We describe and analyze surgical outcomes of 20 patients with spinal cord epidermoid cysts. Read More

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http://dx.doi.org/10.17116/oftalma201882239-47DOI Listing
January 2018
1 Read