35,501 results match your criteria Intrahepatic Cholestasis of Pregnancy


Wuzhi capsule (Schisandra Sphenanthera extract) attenuates liver steatosis and inflammation during non-alcoholic fatty liver disease development.

Biomed Pharmacother 2018 Dec 3;110:285-293. Epub 2018 Dec 3.

Department of Organ Transplantation, ChangZheng Hospital, Second Military Medical University, Shanghai, 200003, China. Electronic address:

Objective: Wuzhi (WZ) capsule contains an ethanol extract of Schisandra sphenanthera. The efficacy of WZ in treating non-alcoholic fatty liver disease (NAFLD) has not yet been elucidated. The present study assessed the effects of WZ on NAFLD. Read More

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December 2018
2.023 Impact Factor

Proteomic Landscape of Cholangiocarcinomas Reveals 3 Different Subgroups According to their Localization and the Aspect of Non-Tumor Liver.

Proteomics Clin Appl 2018 Dec 6:e1800128. Epub 2018 Dec 6.

UMR 1149 INSERM - Paris Diderot University, Inflammation Research Center, Paris, France.

Purpose: Cholangiocarcinomas (CC), tumors derived from epithelial biliary cells, define a heterogeneous entity based upon their anatomic localization (intra- versus extrahepatic) and, for those developing in the liver, depending on the aspect of non-tumor liver (normal versus cirrhosis). The aim of the study was to characterize the molecular heterogeneity of the different types of CC by a global proteomic approach.

Experimental Design: Thirty-three tumor samples from 17 intrahepatic CC (iCC) including 9 and 8 developed on normal (iCC ) and cirrhotic liver (iCC ), respectively; 5 hilar CC (CC ), 5 CC developed in the pancreatic portion of the bile duct (CC ) and 6 hepatocellular carcinoma (HCC), were submitted to label-free quantitative proteomic analysis. Read More

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December 2018

ID3 Promotes Stem Cell Features and Predicts Chemotherapeutic Response of Intrahepatic Cholangiocarcinoma.

Hepatology 2018 Dec 5. Epub 2018 Dec 5.

Department of Liver Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Cancer stem cells (CSCs) are well contributing to high rate of recurrence and chemotherapeutic resistance in many types of cancer including intrahepatic cholangiocarcinoma (ICC). Inhibitor of differentiation 3 (ID3) has been reported to promote cancer stem cells, but its role in ICC is obscure. In this study, we identified that ID3 is highly expressed in human ICC tissues compared with matched normal tissues and correlates with poor prognosis. Read More

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December 2018

CT imaging comparison between intraductal papillary neoplasms of the bile duct and papillary cholangiocarcinomas.

Eur Radiol 2018 Dec 5. Epub 2018 Dec 5.

Department of Radiology, Kanazawa University Graduate School of Medical Science, 13-1 Takaramachi, Kanazawa, 920-8641, Japan.

Objectives: To identify imaging features that assist in discriminating intraductal papillary neoplasms of the bile duct (IPNBs) from papillary cholangiocarcinomas (PCCs).

Methods: This study was approved by the institutional review board. Using the recently proposed histological diagnostic criteria for biliary papillary neoplasms, IPNBs and PCCs were selected from 537 biliary neoplasms consecutively resected in a 12. Read More

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December 2018
1 Read

MicroRNA-18a promotes hepatocellular carcinoma proliferation, migration, and invasion by targeting Bcl2L10.

Onco Targets Ther 2018 9;11:7919-7934. Epub 2018 Nov 9.

Department of General Surgery, Tianjin Medical University General Hospital, Tianjin, China,

Background: Hepatocellular carcinoma (HCC) is known to feature several microRNA dysregulations. This study aimed to determine and investigate the prognostic value of microRNA (miRNA/miR)-18a and its role in regulating the progression of HCC.

Methods: miR-18a expressions in human HCC tissues, pair-matched adjacent normal liver tissues as well as in HCC cell lines were determined by quantitative real-time PCR. Read More

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November 2018

Ectopic fat, insulin resistance and metabolic disease in non-obese Asians: investigating metabolic gradation.

Authors:
Yoshifumi Tamura

Endocr J 2018 Dec 4. Epub 2018 Dec 4.

Department of Metabolism & Endocrinology, Juntendo University Graduate School of Medicine, Tokyo, Japan.

Although metabolic abnormalities commonly occur in non-obese Asians, their pathogenesis is not fully understood. Proton magnetic resonance spectroscopy has been used to analyze intracellular lipids in humans, and results suggest that ectopic fat accumulation in muscle and liver may induce insulin resistance in each tissue independently of obesity. Thus, measurement of ectopic fat currently plays an important role in the study of insulin resistance in non-obese Asians. Read More

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December 2018
4 Reads

Application of real time contrast-enhanced ultrasound in differential diagnosis of liver malignancies.

Authors:
Hongling Li Jin Li

Can J Physiol Pharmacol 2018 Dec 3. Epub 2018 Dec 3.

Puai Hospital affiliated to Tongji Medical College of Huazhong Science and Technology University, Wuhan, China ;

Objective: To evaluate the value of real time contrast-enhanced ultrasound in differential diagnosis of malignant liver tumors.

Methods: 60 patients pathologically diagnosed with liver cancer from May 2016 to May 2017 were selected as the objects. All patients received ultrasonic diagnosis followed by the observation on dynamic contrast enhancement of the image and the analysis on perfusion characteristics and difference in contrast-enhanced ultrasound results in patients with different types of liver cancer. Read More

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December 2018

Amino acid residues in five separate HLA genes can explain most of the known associations between the MHC and primary biliary cholangitis.

PLoS Genet 2018 Dec 3;14(12):e1007833. Epub 2018 Dec 3.

Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom.

Primary Biliary Cholangitis (PBC) is a chronic autoimmune liver disease characterised by progressive destruction of intrahepatic bile ducts. The strongest genetic association is with HLA-DQA1*04:01, but at least three additional independent HLA haplotypes contribute to susceptibility. We used dense single nucleotide polymorphism (SNP) data in 2861 PBC cases and 8514 controls to impute classical HLA alleles and amino acid polymorphisms using state of the art methodologies. Read More

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December 2018

Increased Interleukin-23 Receptor (IL-23R) Expression is Associated with Disease Severity in Acute-on-Chronic Liver Failure.

Liver Int 2018 Dec 2. Epub 2018 Dec 2.

Dept. of Molecular and Cellular Medicine, Institute of Liver and Biliary Sciences, New Delhi, India.

Background: Th17 cells mediated immune response is important in chronic hepatitis B (CHB) infection and inflammation associated diseases, however, little is known about their immunopathogenic role in acute-on-chronic liver failure (ACLF). Interleukin-23 receptor (IL-23R) is essential for the generation of pathogenic Th17 cells, therefore, we aimed to evaluate IL-23R expression and its correlation with disease severity in ACLF.

Methods: Forty two patients with ACLF (HBV and alcohol-related), thirty two with CHB and twenty healthy controls (HC) were studied. Read More

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December 2018

Tei index is associated with survival in cirrhosis patients treated with transjugular intrahepatic portosystemic shunt.

Echocardiography 2018 Dec 1. Epub 2018 Dec 1.

Department of Ultrasound, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.

Background: Transjugular intrahepatic portosystemic shunt (TIPS) is the method of choice for the treatment of portal hypertension. The Tei index is the most sensitive indicator of myocardial function.

Design: This study enrolled 31 patients with cirrhosis who underwent TIPS and were followed up over a median period of 34 months (range 2-60 months). Read More

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December 2018

Changes in arterial oxygenation after portal decompression in Budd-Chiari syndrome patients with hepatopulmonary syndrome.

Eur Radiol 2018 Nov 30. Epub 2018 Nov 30.

Department of Interventional Therapy, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 17 Panjiayuan Nanli, Chaoyang District, Beijing, 100021, China.

Objectives: To evaluate the changes in arterial oxygenation after portal decompression in Budd-Chiari syndrome (BCS) patients with hepatopulmonary syndrome (HPS).

Methods: From June 2014 to June 2015, all patients with BCS who underwent balloon angioplasty or transjugular intrahepatic portosystemic shunt (TIPS) creation at our institution were eligible for inclusion in this study. Arterial blood gas analysis was performed with the patient in an upright position and breathing room air at 2-3 days and 1 and 3 months after the procedure. Read More

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November 2018
1 Read

Current survival and treatment trends for surgically resected intrahepatic cholangiocarcinoma in the United States.

J Gastrointest Oncol 2018 Oct;9(5):942-952

Department of Surgery, University of Minnesota, Minneapolis, MN, USA.

Background: Intrahepatic cholangiocarcinoma (ICC) is a rare and aggressive disease with an increasing incidence in the United States, and there is no level 1 evidence to help guide treatment decisions. We sought to determine national trends in surgical and medical management of patients with resected ICC, and more specifically, the role of lymphadenectomy (LAD) and utilization of chemotherapy.

Methods: An augmented version of the National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) cancer database registry was used to identify all surgically resected ICC patients from 2000 to 2014. Read More

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October 2018

Advances in therapeutic options for portal hypertension.

Therap Adv Gastroenterol 2018 25;11:1756284818811294. Epub 2018 Nov 25.

Liver Vascular Biology Research Group, Barcelona Hepatic Hemodynamic Laboratory, IDIBAPS Biomedical Research Institute, CIBEREHD, Rosselló 149, 4th floor, 08036 Barcelona, Spain.

Portal hypertension represents one of the major clinical consequences of chronic liver disease, having a deep impact on patients' prognosis and survival. Its pathophysiology defines a pathological increase in the intrahepatic vascular resistance as the primary factor in its development, being subsequently aggravated by a paradoxical increase in portal blood inflow. Although extensive preclinical and clinical research in the field has been developed in recent decades, no effective treatment targeting its primary mechanism has been defined. Read More

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November 2018

Epidermal growth factor-like domain multiple 7 (EGFL7): Expression and possible effect on biliary epithelium growth in cholangiocarcinoma.

Eur J Histochem 2018 Nov 30;62(4). Epub 2018 Nov 30.

Sapienza University of Rome, Department of Anatomical, Histological, Forensic Medicine and Orthopedics Sciences.

Cholangiocarcinoma (CCA) is an aggressive biliary tract malignancy with limited treatment options and low survival rates. The intrahepatic subtype comprises two forms: mucin-iCCA and mixed-iCCA. Epidermal growth factor-like domain multiple (EGFL7) is overexpressed in less differentiated liver tumors. Read More

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November 2018
1 Read

SMARCB1/INI1 Is Diagnostically Useful in Distinguishing α-Fetoprotein-producing Gastric Carcinoma from Hepatocellular Carcinoma.

Anticancer Res 2018 Dec;38(12):6865-6868

Department of Pathology, School of Medicine, University of Yamanashi, Chuo, Japan.

Background/aim: Switch/sucrose non-fermentable (SWI/SNF)-related, matrix-associated, actin-dependent regulator of chromatin subfamily B member 1 (SMARCB1), also named integrase interactor 1, is one of the core subunit proteins in the SWI/SNF ATP-dependent chromatin remodeling complex encoded at chromosomal position 22q11.2. Complete loss of SMARCB1 expression has been reported in various malignant tumors. Read More

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December 2018

The diagnostic efficacy of CYFRA21-1 on intrahepatic cholangiocarcinoma: A meta-analysis.

Clin Res Hepatol Gastroenterol 2018 Nov 28. Epub 2018 Nov 28.

Department of clinical laboratory, Third affiliated hospital of Sun Yat-sen University, No. 600, Tianhe road, Guangzhou, Guangdong, PR China. Electronic address:

Objective: To evaluate the reliability and accuracy of Cytokeratin-19-fragment (CYFRA21-1) in the diagnosis of intrahepatic cholangiocarcinoma (ICC) based on literature meta-analysis and the diagnostic efficacy and clinical application of CYFRA21-1 in ICC.

Methods: MEDLINE, China National Knowledge Infrastructure Library and other databases were used to base the inclusion and exclusion criteria. In addition, relevant data from studies on CYFRA21-1 were used to diagnose ICC individually or in combination was retrieved for meta-analysis. Read More

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November 2018

Phase I/II trial of helical IMRT-based stereotactic body radiotherapy for hepatocellular carcinoma.

Dig Liver Dis 2018 Nov 17. Epub 2018 Nov 17.

Department of Radiation Oncology, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Republic of Korea. Electronic address:

Background: To report the results of a phase I/II study of helical IMRT-based stereotactic body radiotherapy (SBRT) for hepatocellular carcinoma (HCC).

Methods: Eligibility included Child-Turcotte-Pugh class A or B, ≤3 lesions, and cumulative tumor diameter ≤6 cm. Dose was escalated from 36 Gy to 60 Gy delivered in 4 fractions. Read More

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November 2018

Percutaneous portal vein recanalization using self-expandable nitinol stents in patients with non-cirrhotic non-tumoral portal vein occlusion.

Diagn Interv Imaging 2018 Nov 28. Epub 2018 Nov 28.

Department of Radiodiagnostic and interventional radiology, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Lausanne, Switzerland.

Purpose: The purpose of this study was to evaluate the feasibility, safety, and efficacy of portal vein recanalization (PVR) and propose a new classification for better selecting candidates with portal vein occlusion (PVO) in whom PVR could be feasible.

Materials And Methods: The charts of 15 non-cirrhotic patients in whom stent placement using a trans-hepatic approach was attempted for the treatment of PVO with cavernous transformation were reviewed. There were 12 men and 5 women with a mean age of 47±12 years (range: 22-60 years). Read More

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November 2018

Percutaneous Creation of Intrahepatic Biliary Tract for Treatment of Posthepatectomy Excluded Segmental Bile Duct Leak.

J Vasc Interv Radiol 2018 Dec;29(12):1770-1772

Department of Radiology, Lahey Hospital and Medical Center, 41 Mall Rd., Burlington, MA 01805.

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December 2018

Paradoxical effects of emodin on ANIT-induced intrahepatic cholestasis and herb-induced hepatotoxicity in mice.

Toxicol Sci 2018 Dec 4. Epub 2018 Dec 4.

School of Pharmaceutical Science and Technology, Tianjin University, Tianjin, China.

Emodin is an active ingredient in many herbal medicines and has a broad spectrum of pharmacological activities. The current data indicate that emodin exerts its beneficial effect on alpha-naphthylisothiocyanate (ANIT)-induced intrahepatic cholestasis through its anti-oxidant and anti-inflammatory activities. Emodin has little effect on the concentrations of bile acids (BAs) in livers of ANIT-treated mice. Read More

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December 2018
3 Reads

Differentiation between inflammatory myofibroblastic tumor and cholangiocarcinoma manifesting as target appearance on gadoxetic acid-enhanced MRI.

Abdom Radiol (NY) 2018 Dec 4. Epub 2018 Dec 4.

Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50, Ilwon-Dong, Kangnam-Ku, Seoul, 135-710, Republic of Korea.

Purpose: To determine the differential features of inflammatory myofibroblastic tumor (IMT) and intrahepatic cholangiocarcinoma (ICC) manifesting as target appearance on gadoxetic acid-enhanced MRI.

Methods: Twenty-seven patients with 36 IMTs (1.2-6. Read More

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December 2018
1 Read

Characterization of intrahepatic cholangiocarcinoma after curative resection: outcome, prognostic factor, and recurrence.

BMC Gastroenterol 2018 Dec 4;18(1):180. Epub 2018 Dec 4.

Department of General Surgery, Chang Gung Memorial Hospital at Linkou, Chang Gung University College of Medicine, 5 Fu-Hsing Street, Kwei-Shan District, Taoyuan City, 33305, Taiwan.

Background: Intrahepatic cholangiocarcinoma (ICC) is a relatively rare subtype of cholangiocarcinoma. The study herein gathered experience of surgical treatment for ICC, and aimed to analyze the prognosis of patients who had received curative-intent liver resection.

Methods: A total of 216 patients who had undergone curative-intent liver resection for ICC between January 1977 and December 2014 was retrospectively reviewed. Read More

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December 2018

Acute Endothelial Benefits of Fat Restriction over Carbohydrate Restriction in Type 2 Diabetes Mellitus: Beyond Carbs and Fats.

Nutrients 2018 Dec 1;10(12). Epub 2018 Dec 1.

Department of Clinical Nutrition, German Institute of Human Nutrition Potsdam-Rehbruecke, 14558 Nuthetal, Germany.

Background: Cardiovascular diseases (CVD) are the major cause of mortality in type 2 diabetes patients (T2DM). The causes are embedded in a complex interplay between excess body fat, insulin resistance and serum lipid anomalies. Endothelial homeostasis is strongly affected by this pathogenic network. Read More

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December 2018
1 Read

Peau et grossesse.

Rev Prat 2017 Apr;67(4):411-414

Service de dermatologie, hôpital Cochin- Tarnier, faculté de médecine Paris-Descartes, Paris, France.

Skin and pregnancy. Skin manifestations during pregnancy are common and diversified. Physiological changes are the most frequently reported. Read More

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April 2017
2 Reads

Substrates of P4-ATPases: beyond aminophospholipids (phosphatidylserine and phosphatidylethanolamine).

FASEB J 2018 Dec 3:fj201801873R. Epub 2018 Dec 3.

Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan.

P4-ATPases, a subfamily of P-type ATPases, were initially identified as aminophospholipid translocases in eukaryotic membranes. These proteins generate and maintain membrane lipid asymmetry by translocating aminophospholipids (phosphatidylserine and phosphatidylethanolamine) from the exoplasmic/lumenal leaflet to the cytoplasmic leaflet. The human genome encodes 14 P4-ATPases, and the cellular localizations, substrate specificities, and cellular roles of these proteins were recently revealed. Read More

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December 2018
2 Reads

Pattern of disease recurrence and its implications for postoperative surveillance after curative hepatectomy for hepatocellular carcinoma: experience from a single center.

Hepatobiliary Surg Nutr 2018 Oct;7(5):320-330

Department of Surgery, Division of Hepatobiliary and Pancreatic Surgery, Prince of Wales Hospital, the Chinese University of Hong Kong, Hong Kong, China.

Background: Hepatectomy is a widely accepted curative treatment for hepatocellular carcinoma (HCC). However, the disease frequently recurs after a curative hepatectomy. The objective of this study is to provide a better understanding of the pattern of disease recurrence and the risk factors involved so as to improve the postoperative surveillance. Read More

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October 2018

Gastrointestinal Bleeding Secondary to Portal Hypertensive Duodenopathy in a Patient with Decompensated Liver Cirrhosis.

Case Rep Gastrointest Med 2018 18;2018:9430701. Epub 2018 Oct 18.

Department of Gastroenterology and Hepatology, Louisiana State University Health Sciences Center, Shreveport, LA, USA.

With alcoholic cirrhosis and nonalcoholic fatty liver disease continuously on the rise in the United States, there is also a corresponding rise in portal hypertension. Portal hypertensive duodenopathy (PHD) is a complication of portal hypertension not commonly seen in cirrhotic patients. We present a case of a 46-year-old man who presented with decompensated liver cirrhosis secondary to gastrointestinal bleed. Read More

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October 2018
3 Reads

Imaging of the intrahepatic portal vein in children with extrahepatic portal vein thrombosis - Comparison of magnetic resonance imaging and retrograde portography.

J Pediatr Surg 2018 Oct 30. Epub 2018 Oct 30.

Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, University of Duisburg-Essen, Hufelandstrasse 55, 45122 Essen, Germany. Electronic address:

Purpose: Extrahepatic portal vein thrombosis (EPVT) is one major cause of portal hypertension in children. Surgical reinstallation of portal venous flow can be achieved in patients with patent intrahepatic portal venous system/Rex recess. Our study aimed to compare the ability of magnetic resonance imaging (MRI) and retrograde portography (RP) to assess patency of the intrahepatic portal venous system in children with EPVT. Read More

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October 2018

Reduced expression of thyroid hormone receptor β in human nonalcoholic steatohepatitis.

Endocr Connect 2018 Nov 1. Epub 2018 Nov 1.

H Kirchner, Lübeck, Germany.

Hepatic thyroid hormone signaling has an important role in the development and progression of nonalcoholic steatohepatitis (NASH). While the systemic levels of thyroid hormone might remain stable, there is evidence that the intracellular signaling machinery consisting of transporters, deiodinases and receptors could be altered in NASH. However, clinical material from human liver biopsies of individuals with NASH has not been studied to date. Read More

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November 2018
2 Reads

Reason of Discontinuation After Transarterial Chemoembolization Influences Survival in Patients with Hepatocellular Carcinoma.

Cardiovasc Intervent Radiol 2018 Nov 28. Epub 2018 Nov 28.

Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands.

Background: Transarterial chemoembolization (TACE) for intermediate-stage hepatocellular carcinoma (HCC) is often repeated until unTACEable progression (UTP) occurs. There is little data on the various reasons for stopping TACE and its consequences for subsequent treatment and survival.

Aim: To assess the impact of the various reasons of UTP on survival and consequences for subsequent treatments. Read More

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November 2018
3 Reads

Stepwise evaluation of liver sectors and liver segments by endoscopic ultrasound.

World J Gastrointest Endosc 2018 Nov;10(11):326-339

Department of Gastroenterology, Sanjay Gandhi Post Graduate Institute, Lucknow 226014, Uttar Pradesh, India.

The liver has eight segments, which are referred to by numbers or by names. The numbering of the segments is done in a counterclockwise manner with the liver being viewed from the inferior surface, starting from Segment I (the caudate lobe). Standard anatomical description of the liver segments is available by computed tomographic scan and ultrasonography. Read More

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November 2018
2 Reads

Incidence and Prevention of Biliary Leakage after Partial Liver Resection in a Tertiary Level Hospital.

Mymensingh Med J 2018 Oct;27(4):737-745

Dr Md Mahboob Hasan, Lieutenant Colonel, Classified Specialist in Surgery and Hepatobiliary Surgeon, Department of Hepatobiliary Surgery, Combined Military Hospital, Dhaka, Bangladesh; E-mail: drmah

Biliary leakage is a postoperative complication of liver resection which may have considerable consequences. The aim of this study is to evaluate the incidence of post hepatectomy biliary leakage and to find out the preventive measures by systemic literature reviews. This observational study was conducted on 500 patients who required various forms of hepatic resection at the Department of Hepatic Surgery - 4, Eastern Hepatobiliary Surgery Hospital of The Second Military Medical University, Shanghai, China from September 2014 to July 2016. Read More

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October 2018

Fine needle aspirates comprehensively sample intrahepatic immunity.

Gut 2018 Nov 28. Epub 2018 Nov 28.

Division of Infection and Immunity, Institute of Immunity and Transplantation, University College London, London, UK.

Objective: In order to refine new therapeutic strategies in the pipeline for HBV cure, evaluation of virological and immunological changes compartmentalised at the site of infection will be required. We therefore investigated if liver fine needle aspirates (FNAs) could comprehensively sample the local immune landscape in parallel with viable hepatocytes.

Design: Matched blood, liver biopsy and FNAs from 28 patients with HBV and 15 without viral infection were analysed using 16-colour multiparameter flow cytometry. Read More

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November 2018
3 Reads

miR-296-5p suppresses EMT of hepatocellular carcinoma via attenuating NRG1/ERBB2/ERBB3 signaling.

J Exp Clin Cancer Res 2018 Nov 29;37(1):294. Epub 2018 Nov 29.

Liver Cancer Institute, Zhongshan Hospital, Fudan University, Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, 180 Fenglin Road, Shanghai, 200032, China.

Background: Accumulation of evidence indicates that miRNAs have crucial roles in the regulation of EMT-associated properties, such as proliferation, migration and invasion. However, the underlying molecular mechanisms are not entirely illustrated. Here, we investigated the role of miR-296-5p in hepatocellular carcinoma (HCC) progression. Read More

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November 2018
2 Reads

Critical Care Management of Gastrointestinal Bleeding and Ascites in Liver Failure.

Semin Respir Crit Care Med 2018 Oct 28;39(5):566-577. Epub 2018 Nov 28.

Division of Gastroenterology and Hepatology, Center for Liver Diseases and Transplantation, Weill Cornell Medical College, New York, New York.

Gastrointestinal (GI) bleeding and ascites are two significant clinical events that frequently present in critically ill patients with chronic liver failure or decompensated cirrhosis. GI bleeding in patients with cirrhosis, particularly portal hypertensive-associated bleeding, carries a high short-term mortality (15-25%) and requires early initiation of a vasoactive agent and antibiotics as well as timely endoscopic management. Conservative transfusion strategies and adequate airway protection are also imperative to assist in bleeding control. Read More

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October 2018
2 Reads

The Serum microRNA Profile of Intrahepatic Cholestasis of Pregnancy: Identification of Novel Noninvasive Biomarkers.

Cell Physiol Biochem 2018 Nov 28;51(3):1480-1488. Epub 2018 Nov 28.

The Affiliated Wuxi Matemity and Child Health Care Hospital of Nanjing Medical University, Wuxi, China.

Background/aims: Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy-specific disease that significantly increases the risk of fetal complications. Here, we measured serum miRNA levels in ICP patients to identify candidate biomarkers for ICP.

Methods: We used the Agilent miRNA array followed by reverse transcription-polymerase chain reaction assays to identify and validate the serum miRNA profiles of 40 pregnant women with ICP and 40 healthy pregnant controls. Read More

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November 2018
2 Reads

Precoagulation with microwave ablation for hepatic parenchymal transection during liver partial resection.

Int J Hyperthermia 2018 Nov 28:1-5. Epub 2018 Nov 28.

b Hepatobiliary/Liver Transplantation Center , The First Affiliated Hospital of Nanjing Medical University , Nanjing , China.

Purpose: To evaluate the feasibility of precoagulation with microwave ablation (MWA) for hepatic parenchymal transection during liver partial resection.

Methods: A total of 66 eligible patients were enrolled in this double-blind, randomized, controlled study. Patients were randomized to receive either the traditional clamp-crushing method (Control group) or the MWA precoagulation method (MWA group) for hepatic parenchymal transection during liver partial resection. Read More

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November 2018

May circulating steroids reveal a predisposition to intrahepatic cholestasis of pregnancy in non-pregnant women?

Physiol Res 2018 Nov;67(Supplementum 3):S499-S510

Department of Gynecology and Obstetrics, General University Hospital and First Faculty of Medicine, Charles University in Prague, Czech Republic, Department of Steroids and Proteohormones, Institute of Endocrinology, Prague, Czech Republic.

Intrahepatic cholestasis of pregnancy (ICP) is a frequent liver disorder, mostly occurring in the third trimester. ICP is not harmful to the mothers but threatens the fetus. The authors evaluated steroid alterations in maternal and mixed umbilical blood to elucidate their role in the ICP development. Read More

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November 2018

A Successfully Treated Case of Intrahepatic Cholangiocarcinoma with Exacerbation of Dermatomyositis.

Case Rep Gastroenterol 2018 Sep-Dec;12(3):622-628. Epub 2018 Oct 23.

Department of Surgery, The Jikei University School of Medicine, Tokyo, Japan.

Dermatomyositis (DM) is often found in conjunction with malignant tumors such as lung, cervical, and breast cancer. However, the association with intrahepatic cholangiocarcinoma (ICC) is extremely rare. Moreover, to our knowledge, there have been no previous reports of DM discovered because of exacerbation of DM. Read More

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October 2018

Ursodeoxycholic acid versus placebo in the treatment of women with intrahepatic cholestasis of pregnancy (ICP) to improve perinatal outcomes: protocol for a randomised controlled trial (PITCHES).

Trials 2018 Nov 27;19(1):657. Epub 2018 Nov 27.

University of Nottingham, Nottingham, UK.

Background: Intrahepatic cholestasis of pregnancy (ICP) is the most common liver disorder specific to pregnancy and presents with maternal pruritus, raised concentrations of serum bile acids and abnormal liver function tests. ICP is associated with increased rates of spontaneous and iatrogenic preterm labour, fetal hypoxia, meconium-stained amniotic fluid and intrauterine death. Some clinicians treat ICP with ursodeoxycholic acid (UDCA) to improve maternal pruritus and biochemical abnormalities. Read More

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November 2018
2 Reads

[Study on characteristics and prognosis of organ failure in patients with hepatitis B virus-associated acute-on-chronic liver failure].

Zhonghua Gan Zang Bing Za Zhi 2018 Oct;26(10):737-743

302 Military Hospital of China, Beijing 100039, China.

To evaluate the incidence, and the characteristics of organ failure in relationship to prognosis in hepatitis B virus-associated acute-on-chronic liver failure (HBV-ACLF) patients using chronic liver failure-sequential organ failure assessment (CLIF-SOFA) score for judgments of clinical treatment and prognosis. Clinical data of 316 patients who were diagnosed as HBV-ACLF during hospitalization from February 2015 to February 2016 were retrospectively analyzed. Intrahepatic and extrahepatic organ failures were assessed according to CLIF-SOFA score, and the relationship between clinical characteristics and prognosis was analyzed. Read More

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October 2018
1 Read

Gene expression profiling of human tissue-resident immune cells: Comparing blood and liver.

J Leukoc Biol 2018 Nov 27. Epub 2018 Nov 27.

Department of Gastroenterology and Hepatology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.

In this study, we describe a method to reliably characterize intrahepatic leukocyte populations using flow cytometry and next-generation RNA sequencing on fresh human liver biopsies. Over the last decades, immune responses of viral hepatitis patients, and of other liver diseases, have been incompletely characterized. Most studies include peripheral blood samples only, foregoing the possibility to investigate the site of inflammation directly. Read More

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November 2018
4.289 Impact Factor

Trends in liver cancer mortality in the United States: Dual burden among foreign- and US-born persons.

Cancer 2018 Nov 27. Epub 2018 Nov 27.

Centers for Disease Control and Prevention, Atlanta, Georgia.

Background: Since the mid-1980s, the burden of liver cancer in the United States has doubled, with 31,411 new cases and 24,698 deaths occurring in 2014. Foreign-born individuals may be more likely to die of liver cancer than individuals in the general US-born population because of higher rates of hepatitis B infection, a low socioeconomic position, and language barriers that limit the receipt of early cancer detection and effective treatment.

Methods: To determine whether liver cancer mortality rates were higher among foreign-born individuals versus US-born individuals in the United States, population-based cancer mortality data were obtained from the National Center for Health Statistics of the Centers for Disease Control and Prevention. Read More

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November 2018
4 Reads

Specific prognostic factors in hepatitis B virus-related and non-hepatitis B virus-related intrahepatic cholangiocarcinoma after macroscopic curative resection.

J Surg Oncol 2018 Nov 27. Epub 2018 Nov 27.

Department of General Surgery, Huashan Hospital, Fudan University, Shanghai, China.

Background: The hepatitis B virus (HBV)-related intrahepatic cholangiocarcinoma (iCCA) was recognized as a unique subtype of iCCA, within particular features in demography, clinicopathology, and genealogy. However, how they predict prognosis, in particular, for HBV- and non-HBV-related iCCA is still unclear.

Methods: Demographic, clinicopathologic, and genetic features were retrospectively collected and reviewed to determine the specific prognostic factors, precisely predicting the overall survival (OS) in HBV-related (n = 119) and non-HBV-related ( n = 149) iCCA patients, respectively. Read More

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November 2018

Primary intrahepatic cholangiocarcinoma with sarcomatous stroma: case report and review of the literature.

Surg Case Rep 2018 Nov 26;4(1):138. Epub 2018 Nov 26.

Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Maidashi 3-1-1, Higashi-ku, Fukuoka, 812-8582, Japan.

Background: Hepatic carcinosarcomas, which include both carcinomatous and sarcomatous elements, are uncommon in adults. Although carcinosarcoma in hepatocellular carcinoma is occasionally reported, carcinosarcoma in intrahepatic cholangiocarcinoma (ICC) is an extremely rare ICC variant. Few such cases have been reported in English and no large study of its clinicopathological features exists. Read More

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November 2018
4 Reads

Prognostic Impact of Tumor Multinodularity in Intrahepatic Cholangiocarcinoma.

J Gastrointest Surg 2018 Nov 26. Epub 2018 Nov 26.

Hepato-Pancreato-Biliary Surgery and Liver transplantation, Pôle des Pathologies Digestives, Hépatiques et de la Transplantation, Hôpital de Hautepierre-Hôpitaux Universitaires de Strasbourg, Université de Strasbourg, 1, Avenue Molière, 67098, Strasbourg, France.

Background: The prognostic value of tumor multinodularity in intrahepatic cholangiocarcinoma (ICC) remains debated. We aimed to evaluate the impact of tumor multinodularity according to the presence and distribution of multiples ICC's nodules.

Methods: A retrospective review of a prospectively maintained database of patients undergoing resection for ICC from January 1995 to September 2017 was performed. Read More

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November 2018
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Transjugular intrahepatic portosystemic shunt as a bridge to liver transplant: Current state and future directions.

Transplant Rev (Orlando) 2018 Oct 31. Epub 2018 Oct 31.

Division of Interventional Radiology, Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, United States; Division of Medical Oncology, Department of Internal Medicine, Yale School of Medicine, New Haven, CT, United States; Yale Cancer Center, Yale School of Medicine, New Haven, CT, United States. Electronic address:

Liver transplantation is one of the mainstays of treatment for liver failure due to severe chronic liver disease. Bridging therapies, such as placement of a transjugular intrahepatic portosystemic shunt (TIPS), are frequently employed to control complications of portal hypertension such as ascites, hydrothorax, and variceal bleeding, and thereby reduce morbidity in patients awaiting transplant. There is no significant difference seen in either graft survival or patient survival between those receiving TIPS pre-transplant and those who do not, although those receiving TIPS placement on average have a longer waiting time on the transplant waitlist. Read More

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October 2018
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Acyclic retinoid and angiotensin-II receptor blocker exert a combined protective effect against diethylnitrosamine-induced hepatocarcinogenesis in diabetic OLETF rats.

BMC Cancer 2018 Nov 26;18(1):1164. Epub 2018 Nov 26.

Third Department of Internal Medicine, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 634-8522, Japan.

Background: Insulin resistance (IR) is closely associated with the progression of hepatocellular carcinoma (HCC). Acyclic retinoid (ACR) targets retinoid X receptor α and reportedly prevents HCC recurrence in clinical practice. Angiotensin-II receptor blocker (ARB) can also inhibit experimental hepatocarcinogenesis and HCC development. Read More

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November 2018
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Innate Immune Cells in Immune Tolerance After Liver Transplantation.

Front Immunol 2018 9;9:2401. Epub 2018 Nov 9.

Department of Hepatic Surgery and Liver Transplantation Center, School of Medicine, Renji Hospital, Shanghai Jiaotong University, Shanghai, China.

Currently, liver transplantation is the most effective treatment for end-stage liver disease. Immunosuppressive agents are required to be taken after the operations, which have significantly reduced rejection rates and improved the short-term (<1 year) survival rates. However, post-transplant complications related to the immunosuppressive therapy have led to the development of new protocols aimed at protecting renal function and preventing cancer and dysmetabolic syndrome. Read More

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November 2018
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