922 results match your criteria Intrahepatic Cholestasis of Pregnancy


ABCB4 / MDR3 in health and disease - at the crossroads of biochemistry and medicine.

Biol Chem 2018 Dec 1. Epub 2018 Dec 1.

Institute of Biochemistry, Heinrich Heine University Düsseldorf, Universitätsstraße 1, D-40225 Düsseldorf, Germany.

Several ABC transporters of the human liver are responsible for the secretion of bile salts, lipids and cholesterol. Their interplay protects the biliary tree from the harsh detergent activity of bile salts. Among these transporters, ABCB4 is essential for the translocation of phosphatidylcholine lipids from the inner to the outer leaflet of the canalicular membrane of hepatocytes. Read More

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http://dx.doi.org/10.1515/hsz-2018-0441DOI Listing
December 2018
1 Read

Liver Enzyme Elevation in Pregnant Women Receiving Antiretroviral Therapy in the ANRS-French Perinatal Cohort.

J Acquir Immune Defic Syndr 2019 Jan 17. Epub 2019 Jan 17.

Professor, Department of Obstetrics and Gynecology, AP-HP, Hôpital Louis Mourier, Colombes, 92700 France, Department of Epidemiology. Centre de Recherche en Épidémiologie et Santé des Populations, Institut National de la Santé et dDe la Recherche Médicale (INSERM) U1018, Le Kremlin-Bicêtre 94270, France. Univ Diderot Paris 7, Paris, France.

Background: High rates of liver enzyme elevation (LEE) in women receiving antiretroviral treatment (ART) during pregnancy have been reported but causes remain unclear. We estimated the prevalence and risk factors of LEE in a national prospective multicenter cohort.

Methods: We studied 5748 pregnant women living with HIV enrolled in the French Perinatal Cohort 2005-2014, treated with ART, with no active hepatitis B or C co-infection. Read More

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http://dx.doi.org/10.1097/QAI.0000000000001963DOI Listing
January 2019
2 Reads

Evaluation of FGF-19 and β-klotho as biomarkers in patients with intrahepatic cholestasis of pregnancy.

Arch Med Sci 2019 Jan 10;15(1):113-119. Epub 2018 Jan 10.

Department of Obstetrics and Gynecology, Health Sciences University Zeynep Kamil Maternity and Children's Research Hospital, Istanbul, Turkey.

Introduction: Fibroblast growth factor-19 (FGF-19) and its co-receptor, beta-klotho, regulate bile acid synthesis in the liver as an enterohepatic feedback mechanism. In this study, our aim was to investigate the circulating FGF-19 and β-klotho levels in intrahepatic cholestasis of pregnancy (ICP) cases.

Material And Methods: A cross-sectional study including 40 women whose pregnancies were complicated with ICP were recruited for the study group. Read More

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http://dx.doi.org/10.5114/aoms.2017.72424DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348354PMC
January 2019
2 Reads

Inflammatory marker YKL-40 levels in intrahepatic cholestasis of pregnancy.

Gynecol Endocrinol 2019 Jan 27:1-3. Epub 2019 Jan 27.

a Obstetrics and Gynecology Department , Kanuni Sultan Süleyman Training and Research Hospital , İstanbul , Turkey.

Intrahepatic cholestasis of pregnancy is a diagnosis of exclusion and presents with unexplained pruritus, abnormal liver function tests, and increased serum bile acid levels, particularly in the third trimester of pregnancy. Serum YKL-40 levels are increased in liver diseases and our aim was to investigate YKL-40 levels in pregnant women with ICP. 40 women with intrahepatic cholestasis of pregnancy and 40 healthy pregnant women were included in this cross-sectional study. Read More

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http://dx.doi.org/10.1080/09513590.2018.1563889DOI Listing
January 2019
1 Read

Adjuvant Use of Rifampin for Refractory Intrahepatic Cholestasis of Pregnancy.

Obstet Gynecol 2019 Feb;133(2):384-385

Baylor University, Houston, Texas Garden Ob GYN, Garden City Long Island, New York Department of Pediatrics Lincoln Medical and Mental Health Center, Bronx, New York Garden OB Gyn, Garden City, Long Island, New York, and Weill Cornell Medical College, New York, New York.

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http://dx.doi.org/10.1097/AOG.0000000000003095DOI Listing
February 2019

Association between bile salt export pump polymorphisms and intrahepatic cholestasis of pregnancy susceptibility: a meta-analysis of case-control studies.

Gynecol Endocrinol 2019 Jan 6:1-5. Epub 2019 Jan 6.

a Department of Pharmacy , Wuxi Maternal and Child Health Hospital , Wuxi , Jiangsu Province , China.

The purpose of this meta-analysis was to investigate the relationship between bile salt export pump (BSEP) polymorphisms and intrahepatic cholestasis of pregnancy (ICP) susceptibility. Retrieved studies from Pubmed, EMBASE, Web of Science, Cochrane Library and CBM databases about BSEP polymorphisms and ICP susceptibility were included. Odds ratio (OR) and 95% confidence interval (CI) and publication bias were calculated. Read More

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https://www.tandfonline.com/doi/full/10.1080/09513590.2018.1
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http://dx.doi.org/10.1080/09513590.2018.1512570DOI Listing
January 2019
9 Reads

Lithocholic acid activates mTOR signaling inducing endoplasmic reticulum stress in placenta during intrahepatic cholestasis of pregnancy.

Life Sci 2019 Feb 31;218:300-307. Epub 2018 Dec 31.

Division of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. Electronic address:

Aims: Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy-specific disorder, which increases risks of adverse fetal outcomes. However, the pathophysiology is not fully understood. Here, we explored the roles of mTOR signaling and ER stress in placenta during ICP. Read More

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http://dx.doi.org/10.1016/j.lfs.2018.12.050DOI Listing
February 2019
1 Read

The role of metabolic disorders in the pathogenesis of intrahepatic cholestasis of pregnancy.

Clin Exp Hepatol 2018 Dec 3;4(4):217-223. Epub 2018 Dec 3.

Department of Gastroenterology and Hepatology, School of Medicine in Katowice, Medical University of Silesia in Katowice, Poland.

Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy-specific liver disorder which typically commences in the late second or third trimester and resolves within 48 hours after delivery. It is characterized by mild to severe pruritus, without any specific dermatologic features, elevated liver enzymes and increased serum bile acids (BA). The etiology of ICP is still not completely explicit. Read More

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http://dx.doi.org/10.5114/ceh.2018.80122DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311745PMC
December 2018
1 Read

Celastrol Attenuates Intrahepatic Cholestasis of Pregnancy by Inhibiting Matrix Metalloproteinases-2 and 9.

Ann Hepatol 2018 Dec;18(1):40-47

Cangzhou Central Hospital, No. 16, Xinhuazhong Road, Cangzhou City, Hebei Province, China.

Introduction And Aim: Matrix metalloproteinase (MMP)-2 and MMP-9 are reported to participate in several pregnancy-related diseases, including intrahepatic cholestasis of pregnancy (ICP), which is a severe liver disorder in pregnant women. Meanwhile, ample evidences have demonstrated that celastrol inhibits the activity and expression of MMPs. The present study aims to examine the effect of celastrol to alleviate symptoms of ICP in rat model. Read More

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http://dx.doi.org/10.5604/01.3001.0012.7860DOI Listing
December 2018
2 Reads

Targeted metabolomics of sulfated bile acids in urine for the diagnosis and grading of intrahepatic cholestasis of pregnancy.

Genes Dis 2018 Dec 31;5(4):358-366. Epub 2018 Jan 31.

Key Laboratory of Clinical Laboratory Diagnostics, Ministry of Education, School of Laboratory Medicine, Chongqing Medical University, Chongqing, 400016, PR China.

Intrahepatic cholestasis of pregnancy (ICP) is related to cholestatic disorder in pregnancy. Total urinary sulfated bile acids (SBAs) were found increased in ICP. We distinguished the metabolic profiling of urinary SBAs in ICP to find potential biomarkers for the diagnosis and grading of ICP. Read More

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http://dx.doi.org/10.1016/j.gendis.2018.01.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304334PMC
December 2018
1 Read

A case control study of risk factors and neonatal outcomes of preterm birth.

Taiwan J Obstet Gynecol 2018 Dec;57(6):814-818

Clinical Medical College, Yangzhou University, Yangzho, 225001, Jiangsu, China; Department of Gynecology and Obstetrics, Northern Jiangsu People's Hospital, Yangzhou, 225001, Jiangsu, China. Electronic address:

Objective: The aim is to examine risk factors and neonatal outcomes of preterm birth and to provide basis in preventing preterm birth.

Materials And Methods: we carried out our study on 1328 term controls and 1328 preterm birth cases. By using multivariable logistic regression procedures we estimated odds ratio (OR) of potential preterm birth risk factors. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10284559183023
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http://dx.doi.org/10.1016/j.tjog.2018.10.008DOI Listing
December 2018
18 Reads

Associations of serum markers screening for Down's syndrome with pregnancy outcomes: A Chinese retrospective cohort study.

Clin Chim Acta 2019 Feb 6;489:130-135. Epub 2018 Dec 6.

Department of Obstetrics and Gynecology, Changzhou Maternity and Child Health Care Hospital Affiliated to Nanjing Medical University, No. 16 Bo Ai Road, Changzhou, Jiangsu Province, China. Electronic address:

Background: We examined the associations between Down's serum screening analytes and pregnancy outcomes in Chinese women.

Methods: A retrospective cohort study of 2470 pregnant women was conducted. Maternal serum triple tests (AFP, fβ-hCG, uE3), maternal characteristics and pregnancy outcomes were recorded from our prenatal screening and hospitalization information system, respectively. Read More

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http://dx.doi.org/10.1016/j.cca.2018.12.001DOI Listing
February 2019
1 Read

The Serum microRNA Profile of Intrahepatic Cholestasis of Pregnancy: Identification of Novel Noninvasive Biomarkers.

Cell Physiol Biochem 2018 28;51(3):1480-1488. Epub 2018 Nov 28.

The Affiliated Wuxi Matemity and Child Health Care Hospital of Nanjing Medical University, Wuxi, China.

Background/aims: Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy-specific disease that significantly increases the risk of fetal complications. Here, we measured serum miRNA levels in ICP patients to identify candidate biomarkers for ICP.

Methods: We used the Agilent miRNA array followed by reverse transcription-polymerase chain reaction assays to identify and validate the serum miRNA profiles of 40 pregnant women with ICP and 40 healthy pregnant controls. Read More

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http://dx.doi.org/10.1159/000495595DOI Listing
January 2019
15 Reads

May circulating steroids reveal a predisposition to intrahepatic cholestasis of pregnancy in non-pregnant women?

Physiol Res 2018 Nov;67(Supplementum 3):S499-S510

Department of Gynecology and Obstetrics, General University Hospital and First Faculty of Medicine, Charles University in Prague, Czech Republic, Department of Steroids and Proteohormones, Institute of Endocrinology, Prague, Czech Republic.

Intrahepatic cholestasis of pregnancy (ICP) is a frequent liver disorder, mostly occurring in the third trimester. ICP is not harmful to the mothers but threatens the fetus. The authors evaluated steroid alterations in maternal and mixed umbilical blood to elucidate their role in the ICP development. Read More

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November 2018
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Ursodeoxycholic acid versus placebo in the treatment of women with intrahepatic cholestasis of pregnancy (ICP) to improve perinatal outcomes: protocol for a randomised controlled trial (PITCHES).

Trials 2018 Nov 27;19(1):657. Epub 2018 Nov 27.

University of Nottingham, Nottingham, UK.

Background: Intrahepatic cholestasis of pregnancy (ICP) is the most common liver disorder specific to pregnancy and presents with maternal pruritus, raised concentrations of serum bile acids and abnormal liver function tests. ICP is associated with increased rates of spontaneous and iatrogenic preterm labour, fetal hypoxia, meconium-stained amniotic fluid and intrauterine death. Some clinicians treat ICP with ursodeoxycholic acid (UDCA) to improve maternal pruritus and biochemical abnormalities. Read More

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http://dx.doi.org/10.1186/s13063-018-3018-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260710PMC
November 2018
7 Reads

Expanding the mutational spectrum of the ABCB4 gene in inherited adult cholestatic liver disorders with four novel pathogenic variants.

Rev Esp Enferm Dig 2019 Jan;111(1):76-79

Genetics service, Laboratoire commun de Biologie et Génétique Moléculaires, Hôpitaux universitaires Est Parisien, hôpi, France.

Low phospholipid-associated cholelithiasis and intrahepatic cholestasis of pregnancy are two MDR3-related inherited liver disorders caused by biallelic or monoallelic ABCB4 loss-of-function variants. Low phospholipid-associated cholelithiasis is clinically characterized by the early onset of symptomatic cholelithiasis in young adults while intrahepatic cholestasis of pregnancy is a distinct clinical entity associated with adverse fetal outcomes. Of note, patients carrying ABCB4 sequence variations commonly exhibit phenotypic expression over a wide continuum due to environmental and hormonal contributing factors and genetic modifiers. Read More

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http://dx.doi.org/10.17235/reed.2018.5828/2018DOI Listing
January 2019
1 Read
1.317 Impact Factor

Ductopenia and cirrhosis in a 32-year-old woman with progressive familial intrahepatic cholestasis type 3: A case report and review of the literature.

World J Gastroenterol 2018 Nov;24(41):4716-4720

Department of Hepatology, The Third Hospital of Zhenjiang Affiliated Jiangsu University, Zhenjiang 212003, Jiangsu Province, China.

Progressive familial intrahepatic cholestasis type 3 is caused by a mutation in the ATP-binding cassette, subfamily B, member 4 () gene encoding multidrug resistance protein 3. A 32-year-old woman with a history of acute hepatitis at age 9 years was found to have jaundice during pregnancy in 2008, and was diagnosed as having intrahepatic cholestasis of pregnancy. In 2009, she underwent cholecystectomy for gallstones and chronic cholecystitis. Read More

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http://dx.doi.org/10.3748/wjg.v24.i41.4716DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224472PMC
November 2018
3 Reads

Intrahepatic cholestasis of pregnancy: Review of six national and regional guidelines.

Eur J Obstet Gynecol Reprod Biol 2018 Dec 26;231:180-187. Epub 2018 Oct 26.

Department of Obstetrics, Gynecology and Reproductive Sciences, Division of Maternal-Fetal Medicine, University of Texas Health Science Center, Houston, TX, USA.

Intrahepatic cholestasis of pregnancy (ICP) is a poorly understood disease of the late second or third trimester of pregnancy, typically associated with rapid resolution following delivery. It is characterized by pruritis, elevated serum bile acids, and abnormal liver function tests and has been linked to stillbirth, meconium passage, respiratory distress syndrome and fetal asphyxial events. The incidence is highly variable, dependent both on the ethnic makeup of the population as well as the diagnostic criteria being used. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03012115183105
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http://dx.doi.org/10.1016/j.ejogrb.2018.10.041DOI Listing
December 2018
8 Reads

[Development of a Predictive Model for Adverse Outcomes of Preeclampsia].

Sichuan Da Xue Xue Bao Yi Xue Ban 2018 Sep;49(5):797-802

Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu 610041, China.

Objective: To determine factors associated with adverse outcomes of preeclampsia and develop a predictive model.

Methods: Clinical data of 2 532 patients with preeclampsia who were admitted to our hospital from 2005 to 2014 were extracted for the study. The patients were divided into two groups, including 990 (39. Read More

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September 2018
3 Reads

Specific dermatoses of pregnancy other than pemphigoid gestationis.

G Ital Dermatol Venereol 2018 Oct 29. Epub 2018 Oct 29.

Section of Dermatology, Department of Surgery and Translational Medicine, University of Florence, Florence, Italy.

Specific dermatoses of pregnancy are skin disorders that occur specifically during or immediately after pregnancy and cannot be found in non-pregnant patients. According to the current consensus, they include atopic eruption of pregnancy (AEP), polymorphic eruption of pregnancy (PEP), pemphigoid gestationis (PG), and intrahepatic cholestasis of pregnancy (ICP). The diagnosis of specific dermatoses of pregnancy can be challenging due to their variation in clinical presentation; moreover, the tests currently available do not always provide the clue for the diagnosis. Read More

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http://dx.doi.org/10.23736/S0392-0488.18.06159-XDOI Listing
October 2018
2 Reads

Intrahepatic cholestasis of pregnancy.

Cutis 2018 09;102(3):E26-E27

National Skin Centre, Singapore.

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September 2018
1 Read

Sexually acquired acute hepatitis C infection diagnosed during pregnancy: a case report of successful postpartum treatment.

Case Rep Womens Health 2018 Oct 19;20:e00080. Epub 2018 Sep 19.

Emory University School of Medicine, Department of Medicine, Division of Infectious Diseases, Atlanta, GA, United States.

Background: Infection with the hepatitis C virus (HCV) during pregnancy has emerged as an increasingly recognized and prevalent condition among women of reproductive age in the United States. While screening recommendations exist for pregnant women at high risk of HCV infection, pregnant women with HCV are often under-screened, not diagnosed, or do not receive adequate follow-up, thereby increasing the risk of suboptimal maternal and infant outcomes (including in future pregnancies).

Case: A pregnant woman living with HIV presented with intrahepatic cholestasis of pregnancy. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22149112183008
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http://dx.doi.org/10.1016/j.crwh.2018.e00080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197435PMC
October 2018
14 Reads

ABCB4 Gene Aberrations in Human Liver Disease: An Evolving Spectrum.

Semin Liver Dis 2018 Nov 24;38(4):299-307. Epub 2018 Oct 24.

Department of Medicine II, Saarland University Medical Center, Saarland University, Homburg, Germany.

ATP-binding cassette subfamily B member 4 (ABCB4) is a phospholipid translocator at the canalicular membrane of the hepatocyte, which "flops" phosphatidylcholine into bile. Dysfunction of this transporter due to gene variants can cause liver diseases and has been called ABCB4 deficiency. Several diseases including progressive familial intrahepatic cholestasis type 3 (PFIC3), low phospholipid-associated cholelithiasis (LPAC), a subgroup of patients developing intrahepatic cholestasis of pregnancy (ICP), drug-induced liver injury and chronic cholangiopathy with biliary fibrosis and cirrhosis were attributed to ABCB4 deficiency and characterized in the past decade. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0038-1667299
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http://dx.doi.org/10.1055/s-0038-1667299DOI Listing
November 2018
11 Reads

Is It Necessary to Perform the Pharmacological Interventions for Intrahepatic Cholestasis of Pregnancy? A Bayesian Network Meta-Analysis.

Clin Drug Investig 2019 Jan;39(1):15-26

Center for Liver Diseases, Nantong Third People's Hospital, Nantong University, 60 Mid-Youth Road, Nantong, 226006, Jiangsu, China.

Background And Objective: Although many meta-analyses have evaluated the pharmacotherapy of intrahepatic cholestasis of pregnancy (ICP) and recommended ursodeoxycholic acid (UDCA) as an effective treatment, the defect of the pair-wise analyses and the mixture of the control group made the outcome uncertain and unclear. We aimed to employ Bayesian network meta-analysis (NMA) to compare the maternal and fetal outcomes after UDCA, S-adenosylmethionine (SAMe) mono-therapy or the combination treatment of these two drugs for ICP patients.

Methods: Multiple electronic database searches were conducted for articles published up to 1 September 2018. Read More

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http://dx.doi.org/10.1007/s40261-018-0717-2DOI Listing
January 2019
5 Reads
1.704 Impact Factor

Liver stiffness reversibly increases during pregnancy and independently predicts preeclampsia.

World J Gastroenterol 2018 Oct;24(38):4393-4402

Department of Medicine and Center for Alcohol Research, Liver Disease and Nutrition, Salem Medical Center, University of Heidelberg, Heidelberg 69121, Germany.

Aim: To study liver stiffness (LS) during pregnancy and its association with complications during pregnancy.

Methods: In this observational, diagnostic study, 537 pregnant women were prospectively enrolled at the Department of Obstetrics and Gynecology, University hospital Heidelberg and Salem Medical Center. LS was measured using the Fibroscan device (Echosens, Paris) in all women and in 41 cases 24 h after delivery. Read More

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http://dx.doi.org/10.3748/wjg.v24.i38.4393DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6189842PMC
October 2018
2 Reads

Therapeutic plasma exchange as a novel treatment for severe intrahepatic cholestasis of pregnancy: Case series and mechanism of action.

J Clin Apher 2018 Dec 15;33(6):638-644. Epub 2018 Oct 15.

Department of Women and Children's Health, King's College London, London, United Kingdom.

Introduction: Intrahepatic cholestasis of pregnancy is characterised by pruritus and elevated serum bile acids. The pruritus can be severe, and pharmacological options achieve inconsistent symptomatic improvement. Raised bile acids are linearly associated with adverse fetal outcomes, with existing management of limited benefit. Read More

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http://doi.wiley.com/10.1002/jca.21654
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http://dx.doi.org/10.1002/jca.21654DOI Listing
December 2018
3 Reads

[MicroRNA-221/222 participates in the pathogenesis of intrahepatic cholestasis of pregnancy via promoting the apoptosis of human placental trophoblast HTR-8 cells].

Authors:
L X Ji J Liu

Zhonghua Gan Zang Bing Za Zhi 2018 Aug;26(8):607-611

Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China.

MicroRNA-221/222 is involved in the pathogenesis of intrahepatic cholestasis of pregnancy (ICP) to promote the apoptosis of placental bile acids through human trophoblastic cells. This study investigates the effects of miR-221/222 on proliferation, apoptosis and apoptosis-related proteins of human trophoblast HTR-8/SVneo (HTR-8 cells) to understand its role in promoting trophoblastic apoptosis. The experiment was divided into transfection group and negative control group. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1007-3418.2018.08.009DOI Listing
August 2018
1 Read

Assessment of fetal left ventricular modified myocardial performance index and its prognostic significance for adverse perinatal outcome in intrahepatic cholestasis of pregnancy.

J Matern Fetal Neonatal Med 2018 Oct 12:1-11. Epub 2018 Oct 12.

a Cerrahpasa Medical Faculty , Department of Perinatology , Istanbul University , Istanbul , Turkey.

Objective: To investigate the association between fetal left ventricular modified myocardial performance index (LMPI) and intrahepatic cholestasis of pregnancy (ICP). And to evaluate the value of LMPI in predicting adverse perinatal outcomes in ICP.

Study Design: In a cross-sectional case-control study, 40 women with ICP were compared with 40 gestational age-matched healthy controls. Read More

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https://www.tandfonline.com/doi/full/10.1080/14767058.2018.1
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http://dx.doi.org/10.1080/14767058.2018.1535588DOI Listing
October 2018
12 Reads

Linc02527 promoted autophagy in Intrahepatic cholestasis of pregnancy.

Cell Death Dis 2018 Sep 24;9(10):979. Epub 2018 Sep 24.

Department of Obstetrics and Gynecology, Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.

LncRNA plays a crucial role in human disease. However, the expression and function of LncRNA in ICP(Intrahepatic cholestasis of pregnancy) is still not fully elucidated. In this study, we found Linc02527 was increased expression in placenta and serum of ICP patients. Read More

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http://dx.doi.org/10.1038/s41419-018-1013-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155230PMC
September 2018
3 Reads
5.010 Impact Factor

PPARγ provides anti-inflammatory and protective effects in intrahepatic cholestasis of pregnancy through NF-κB pathway.

Biochem Biophys Res Commun 2018 Oct 12;504(4):834-842. Epub 2018 Sep 12.

Department of Gynecology and Obstetrics, Wuxi Maternal and Child Health Hospital, The Affiliated Hospital of Nanjing Medical University, Wuxi, Jiangsu, 214002, China. Electronic address:

Aims: Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy-specific hepatic disorder with potentially deleterious consequences of fetuses. Although the intimate relationship between ICP and peroxisome proliferator-activated receptor γ (PPARγ) has been previously reported in physiological and pathological conditions, the detailed mechanisms in the process of intrahepatic cholestasis of pregnancy has been unclear. The aims of this study are to assess the role of PPARγ regulating the reactive oxygen species (ROS) and inflammation in the process of the ICP. Read More

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http://dx.doi.org/10.1016/j.bbrc.2018.09.035DOI Listing
October 2018
8 Reads

Acute fatty liver of pregnancy in a woman with ulcerative colitis and familial hidradenitis suppurativa.

Authors:
Adam Morton

Obstet Med 2018 Sep 19;11(3):141-143. Epub 2017 Nov 19.

Obstetric Medicine, University of Queensland, Queensland, Australia.

Acute fatty liver of pregnancy is a heterogeneous disorder which may occur in the absence of a detectable gene mutation for the enzyme long-chain L-3-hydroxyacyl-CoA dehydrogenase. Acute fatty liver of pregnancy has been reported to complicate several gastrointestinal disorders including viral hepatitis, chronic active hepatitis and intrahepatic cholestasis of pregnancy. A case of acute fatty liver of pregnancy in a woman with ulcerative colitis and familial hidradenitis suppurativa without a detectable gene mutation is presented. Read More

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http://dx.doi.org/10.1177/1753495X17736716DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6134355PMC
September 2018
3 Reads

Waveform analysis of the fetal ECG in labor in patients with intrahepatic cholestasis of pregnancy.

J Obstet Gynaecol Res 2019 Feb 11;45(2):306-312. Epub 2018 Sep 11.

Department of Obstetrics and Gynecology, Turku University Hospital, Turku, Finland.

Aim: Intrahepatic cholestasis of pregnancy (ICP) is reported to be associated with an increased risk of sudden fetal death. The possible mechanism is thought to be cardiac arrhythmia. Prolonged QT interval of the electrocardiogram (ECG) is associated with arrhytmogenic events. Read More

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http://dx.doi.org/10.1111/jog.13812DOI Listing
February 2019
16 Reads

New Insights in Genetic Cholestasis: From Molecular Mechanisms to Clinical Implications.

Can J Gastroenterol Hepatol 2018 26;2018:2313675. Epub 2018 Jul 26.

Department of Gastroenterology, Hepatology, Nutritional Disorders and Pediatrics, The Children's Memorial Health Institute (CMHI), Warsaw 04-730, Poland.

Cholestasis is characterised by impaired bile secretion and accumulation of bile salts in the organism. Hereditary cholestasis is a heterogeneous group of rare autosomal recessive liver disorders, which are characterised by intrahepatic cholestasis, pruritus, and jaundice and caused by defects in genes related to the secretion and transport of bile salts and lipids. Phenotypic manifestation is highly variable, ranging from progressive familial intrahepatic cholestasis (PFIC)-with onset in early infancy and progression to end-stage liver disease-to a milder intermittent mostly nonprogressive form known as benign recurrent intrahepatic cholestasis (BRIC). Read More

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http://dx.doi.org/10.1155/2018/2313675DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6083523PMC
February 2019
14 Reads

Adjuvant Use of Rifampin for Refractory Intrahepatic Cholestasis of Pregnancy.

Obstet Gynecol 2018 Sep;132(3):678-681

Department of Obstetrics & Gynecology, Beaumont Health System, Royal Oak, Michigan; the Center for Pregnancy and Newborn Research, Department of Obstetrics & Gynecology, University of Texas Health Sciences Center at San Antonio, and the Department of Obstetrics & Gynecology, University Health System, San Antonio, Texas.

Background: Intrahepatic cholestasis of pregnancy is an incompletely understood disease that poses significant fetal risks, including stillbirth. Treatment of intrahepatic cholestasis of pregnancy is aimed at relieving maternal symptoms and improving fetal outcomes.

Case: A 21-year-old gravid woman, 3 para 0111, presented at 27 2/7 weeks of gestation with severe intrahepatic cholestasis of pregnancy. Read More

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http://Insights.ovid.com/crossref?an=00006250-201809000-0001
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http://dx.doi.org/10.1097/AOG.0000000000002794DOI Listing
September 2018
11 Reads

Novel compound heterozygous ABCC2 variants in patients with Dubin-Johnson syndrome and intrahepatic cholestasis of pregnancy.

Clin Genet 2018 Nov 9;94(5):480-481. Epub 2018 Aug 9.

Laboratoire commun de Biologie et Génétique Moléculaires, APHP, hôpital Saint-Antoine, Paris, France.

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http://dx.doi.org/10.1111/cge.13420DOI Listing
November 2018
2 Reads

The role of ABC transporters' gene polymorphism in the etiology of intrahepatic cholestasis of pregnancy.

Ginekol Pol 2018 ;89(7):393-397

Division of Perinatology and Women's Diseases, Poznan University of Medical Sciences, Poznan, Poland; Laboratory of Molecular Biology, Division of Perinatology and Women's Diseases, Poznan University of Medical Sciences, Poznan, Poland.

Objectives: The etiology of intrahepatic cholestasis of pregnancy (ICP) involves environmental, hormonal and genetic factors. It is thought that ICP may be related to the polymorphic variants of several genes involved in the metabolism and transport of bile acids (BA). The goal of our study was to evaluate the possible role of genetic polymorphic variants of ABC transporters in patients with ICP. Read More

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http://dx.doi.org/10.5603/GP.a2018.0067DOI Listing
October 2018
4 Reads

Magnesium sulphate can alleviate oxidative stress and reduce inflammatory cytokines in rat placenta of intrahepatic cholestasis of pregnancy model.

Arch Gynecol Obstet 2018 Sep 23;298(3):631-638. Epub 2018 Jul 23.

Zhejiang Provincial People's Hospital, Hangzhou, 310014, China.

Purpose: In our study, we try to investigate whether magnesium sulphate (MgSO) could provide protection against oxidative damage and inflammatory response in rat placenta of intrahepatic cholestasis of pregnancy (ICP) model.

Methods: The rat model of ICP was established by injecting s.c. Read More

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http://dx.doi.org/10.1007/s00404-018-4850-1DOI Listing
September 2018
4 Reads

Could first- and second-trimester biochemical markers for Down syndrome have a role in predicting intrahepatic cholestasis of pregnancy?

Arch Med Sci 2018 Jun 5;14(4):846-850. Epub 2017 Sep 5.

Department of Obstetrics and Gynecology, Faculty of Medicine, Erciyes University, Kayseri, Turkey.

Introduction: The aim of this study is to compare first- and second-trimester Down syndrome biochemical screening markers in intrahepatic cholestasis of pregnancy (ICP) and normal pregnancies.

Material And Methods: This observational case-control study was conducted at Health Sciences University Zeynep Kamil Maternity and Children's Health Training and Research Hospital and the Department of Obstetrics and Gynecology at Erciyes University Medical Faculty during 2016-2017. The study included 165 patients, and consisted of 62 women who had been diagnosed with ICP (the ICP-diagnosed group) and 103 healthy pregnant women (the control group). Read More

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http://dx.doi.org/10.5114/aoms.2017.69865DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6040116PMC
June 2018
21 Reads

Biliary transporter gene mutations in severe intrahepatic cholestasis of pregnancy: Diagnostic and management implications.

J Gastroenterol Hepatol 2019 Feb 6;34(2):425-435. Epub 2018 Aug 6.

Obstetric Medicine, Women's and Children's Hospital, North Adelaide, South Australia, Australia.

Background And Aims: Clinical syndromes associated with biallelic mutations of bile acid (BA) transporters usually present in childhood. Subtle mutations may underlie intrahepatic cholestasis of pregnancy (ICP) and oral contraceptive steroid (OCS) induced cholestasis. In five women with identified genetic mutations of such transporters, with eight observed pregnancies complicated by ICP, we examined relationships between transporter mutations, clinical phenotypes, and treatment outcomes. Read More

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http://dx.doi.org/10.1111/jgh.14376DOI Listing
February 2019
13 Reads

Perinatal outcomes in intrahepatic cholestasis of pregnancy with monochorionic diamniotic twin pregnancy.

BMC Pregnancy Childbirth 2018 Jul 6;18(1):291. Epub 2018 Jul 6.

Department of Obstetrics and Gynecology, Chengdu Women and Children's Central Hospital, Chengdu City, Sichuan Province, China.

Background: The primary aim of the study is to investigate the perinatal outcomes in intrahepatic cholestasis of pregnancy (ICP) with monochorionic diamniotic (MCDA) twin pregnancy.

Methods: This study is a retrospective observational study for women with ICP and MCDA twin pregnancy. Included cases were divided into mild ICP group (10-39 mmol/L) and severe ICP group (> = 40 mmol/L), whose perinatal outcomes were compared between this two groups and whose predictors of adverse perinatal outcomes were evaluated. Read More

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http://dx.doi.org/10.1186/s12884-018-1913-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6035470PMC
July 2018
5 Reads

Low serum vitamin D level is associated with intrahepatic cholestasis of pregnancy.

J Obstet Gynaecol Res 2018 Sep 6;44(9):1712-1718. Epub 2018 Jul 6.

Zekai Tahir Burak Women's Health Care, Training and Research Hospital, Ankara, Turkey.

Aim: Intrahepatic cholestasis of pregnancy (ICP) is a unique hepatic disorder of pregnancy and is related to adverse maternal and perinatal outcomes. The pathogenesis of the disease is not clear and appears to be multifactorial. There is increasing evidence that vitamin D (Vit D) plays a role in hepatobiliary homeostasis and in various liver diseases. Read More

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http://dx.doi.org/10.1111/jog.13693DOI Listing
September 2018
28 Reads

Transport mechanism of ursodeoxycholic acid in human placental BeWo cells.

Biopharm Drug Dispos 2018 Jul 12;39(7):335-343. Epub 2018 Aug 12.

School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China.

Ursodeoxycholic acid (UDCA) is a first-line drug to treat intrahepatic cholestasis of pregnancy (ICP). However, its effects on the fetus are not clearly known. To better guide its clinical use, we aimed to study the mechanism underlying the placental transport of UDCA. Read More

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http://doi.wiley.com/10.1002/bdd.2150
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http://dx.doi.org/10.1002/bdd.2150DOI Listing
July 2018
15 Reads

Effect of inducible nitric oxide synthase and neuropeptide Y in plasma and placentas from intrahepatic cholestasis of pregnancy.

J Obstet Gynaecol Res 2018 Aug 28;44(8):1377-1383. Epub 2018 Jun 28.

Department of Obstetrics and Gynecology, The First Affiliated Hospital of SooChow University, Suzhou, China.

Aim: To analyze inducible nitric oxide synthase (iNOS) and neuropeptide Y (NPY) expression in maternal plasma and placentas of human with intrahepatic cholestasis of pregnancy (ICP).

Methods: The plasma and placentas were collected from 35 women with normal pregnancies and 33 women with ICP. Enzyme-linked immunosorbent assays were used to investigate maternal plasma iNOS and NPY levels. Read More

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http://dx.doi.org/10.1111/jog.13681DOI Listing
August 2018
7 Reads

Pruritus in Pregnancy and Its Management.

Authors:
Mark A Bechtel

Dermatol Clin 2018 Jul 26;36(3):259-265. Epub 2018 Apr 26.

Division of Dermatology, Ohio State University College of Medicine, 540 Officenter Place, #240, Gahanna, OH 43230, USA. Electronic address:

Pruritus in pregnancy can be a source of significant discomfort in the pregnant patient. Some cases are associated with pregnancy-specific dermatoses, although some patients experience a flare of a preexisting dermatosis. Severe pruritus may be a manifestation of a pregnancy-specific dermatosis associated with increased fetal risks and complications. Read More

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http://dx.doi.org/10.1016/j.det.2018.02.012DOI Listing
July 2018
10 Reads

Role of the placenta in serum autotaxin elevation during maternal cholestasis.

Am J Physiol Gastrointest Liver Physiol 2018 Sep 21;315(3):G399-G407. Epub 2018 Jun 21.

Experimental Hepatology and Drug Targeting (HEVEFARM), IBSAL, University of Salamanca , Salamanca , Spain.

Intrahepatic cholestasis of pregnancy (ICP) is frequently accompanied by pruritus, whose etiology has been associated with an enhanced production of lysophosphatidic acid (LPA) by the combined action of phospholipase A1/A2 (PLA1/PLA2) and autotaxin (ATX). Here, we have investigated whether the placenta is involved in LPA release to maternal circulation during ICP. Serum levels of ATX and LPA (determined by ELISA) were elevated in women with ICP, and a correlation between both parameters was found. Read More

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http://dx.doi.org/10.1152/ajpgi.00112.2018DOI Listing
September 2018
6 Reads

Intrahepatic cholestasis of pregnancy and associated causes of death: a cohort study with follow-up of 27-46 years.

BMC Womens Health 2018 06 19;18(1):98. Epub 2018 Jun 19.

Department of General Practice, Faculty of Medicine and Life Sciences, University of Tampere, 33100, Tampere, Finland.

Background: The aim of this study was to determine whether intrahepatic cholestasis of pregnancy (ICP) is associated with causes of death during on average 35 years follow-up after the delivery.

Methods: The study population comprised 571 women with ICP in at least one pregnancy seen at Tampere University Hospital, Finland, between 1969 and 1988. ICP was verified from patient records. Read More

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http://dx.doi.org/10.1186/s12905-018-0606-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6006795PMC
June 2018
4 Reads

Liver Disease During Pregnancy: A Challenging Clinical Issue.

Med Sci Monit 2018 Jun 15;24:4080-4090. Epub 2018 Jun 15.

Department of Gastroenterology, University Hospital Center (UHC) Rijeka, School of Medicine, University of Rijeka, Rijeka, Croatia.

One of the least studied topics in the field of obstetrics is liver disease during pregnancy, which creates a challenge for both gynecologists and hepatologists. Approximately 3% of pregnant women are affected by some form of liver disease during pregnancy. Some of these conditions can be fatal for both the mother and child. Read More

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http://dx.doi.org/10.12659/MSM.907723DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6034557PMC
June 2018
4 Reads

Predictive factors for successful cervical ripening using a double-balloon catheter after previous cesarean delivery.

Int J Gynaecol Obstet 2018 Sep 29;142(3):288-294. Epub 2018 Jun 29.

Department of Obstetrics and Gynecology, Centre Hospitalier Departemental, La Roche-sur-Yon, France.

Objective: To identify predictors of successful cervical ripening using double-balloon catheter (DBC) for labor induction among women with previous cesarean delivery (PCD) and unfavorable cervix at term.

Methods: The present prospective observational study was conducted among women who underwent cervical ripening with DBC at a French tertiary care hospital between January 1, 2014, and December 31, 2017. Inclusion criteria were PCD; singleton term fetus; cephalic presentation; and unfavorable cervix (Bishop score <6). Read More

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http://dx.doi.org/10.1002/ijgo.12566DOI Listing
September 2018
3 Reads

Assessment of circulating betatrophin levels in intrahepatic cholestasis of pregnancy.

J Matern Fetal Neonatal Med 2018 Jun 11:1-6. Epub 2018 Jun 11.

a Department of Maternal-Fetal Medicine Unit , University of Health Sciences, Zekai Tahir Burak Women's Health Education and Research Hospital , Ankara , Turkey.

Objective: To investigate maternal serum levels of betatrophin and their relationship with total bile acid (TBA) levels in patients with intrahepatic cholestasis of pregnancy (ICP).

Materials And Methods: Fifty-nine pregnant women with ICP (31 patients with severe and 28 patients with mild disease classifications) and 23 healthy women with uncomplicated pregnancies as the control group included the study. The maternal betatrophin, fasting blood glucose, fasting insulin (FI), and homeostatic model assessment of insulin resistance (HOMA-IR) levels of the groups were compared. Read More

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http://dx.doi.org/10.1080/14767058.2018.1481382DOI Listing
June 2018
17 Reads

Resveratrol regulates the silent information regulator 1-nuclear factor-κB signaling pathway in intrahepatic cholestasis of pregnancy.

Hepatol Res 2018 Nov 8;48(12):1031-1044. Epub 2018 Aug 8.

Department of Obstetrics and Gynecology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Aim: Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy-specific liver disease characterized by raised serum bile acids and adverse fetal outcomes. In this study, we aimed to explore the molecular and biochemical mechanism of resveratrol in regulating the silent information regulator 1-nuclear factor-κB (SIRT1-NF-κB) signaling pathway and bile acid biosynthesis in ICP.

Methods: We analyzed serum and placenta samples from 30 normal and ICP pregnancy women. Read More

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http://doi.wiley.com/10.1111/hepr.13198
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http://dx.doi.org/10.1111/hepr.13198DOI Listing
November 2018
4 Reads