1,246 results match your criteria Intrahepatic Cholestasis of Pregnancy


Serum Bile Acids in Intrahepatic Cholestasis of Pregnancy (ICP), Versus Pregnant and Nonpregnant Controls in Asian Indian Women and a Proposed Scoring to Optimize Management in ICP.

J Obstet Gynaecol India 2022 Jun 26;72(3):218-224. Epub 2021 Jun 26.

Present Address: Department of Obstetrics and Gynaecology, All India Institute of Medical Sciences, New Delhi, India.

Objectives: This prospective clinical trial was conducted to assess serum bile acids (BA) levels in women with intrahepatic cholestasis of pregnancy (ICP) compared to both pregnant and non-pregnant controls; and evaluate perinatal outcome in relation to bile acid levels. A scoring is proposed based on biochemical markers to optimize management in ICP cases.

Materials And Methods: Serum bile-acids(BA) were assessed in 71 intrahepatic-cholestasis of pregnancy(ICP) cases (group-I), versus 50 pregnant (group-II) and 35 non-pregnant (group-III) controls. Read More

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Changing Trends of Adverse Pregnancy Outcomes With Maternal Pre-pregnancy Body Mass Index: A Join-Point Analysis.

Front Med (Lausanne) 2022 3;9:872490. Epub 2022 Jun 3.

Department of Obstetrics, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China.

Objective: Adverse pregnancy outcomes have been related to obesity and thinness; however, the changing trends of the specific outcome with pre-pregnancy BMI remain unknown. The aim of this study was to investigate the change in risk trends of specific adverse outcomes for different pre-pregnancy BMI and analyze the recommended BMI range for pre-pregnancy counseling.

Methods: Data were extracted from the medical records of 39 public hospitals across 14 provinces in China from 2011 to 2012. Read More

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Bile-acid levels and lung maturity test in patients with intrahepatic cholestasis of pregnancy.

J Perinat Med 2022 Jun 20. Epub 2022 Jun 20.

Department of OBGYN, New York Medical College, Valhalla, NY, USA.

Objectives: Prolonged fetal exposure to maternal bile acids have been linked to fetal lung injury, but it is not known if it affects production of surfactant or fetal lung maturity tests. We set out to determine if elevated total bile acid (TBA) levels predict delayed fetal lung maturity (FLM) in patients with intrahepatic cholestasis of pregnancy (ICP).

Methods: A retrospective cohort study examining patients with ICP who underwent amniocentesis between 36+0 and 37+6 between 2005 and 2014. Read More

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Deep Learning Algorithm-Based Magnetic Resonance Imaging Feature-Guided Serum Bile Acid Profile and Perinatal Outcomes in Intrahepatic Cholestasis of Pregnancy.

Comput Math Methods Med 2022 6;2022:8081673. Epub 2022 Jun 6.

Department of Obstetrics, The Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University, Huai'an, 223300 Jiangsu, China.

This study was aimed to explore magnetic resonance imaging (MRI) based on deep learning belief network model in evaluating serum bile acid profile and adverse perinatal outcomes of intrahepatic cholestasis of pregnancy (ICP) patients. Fifty ICP pregnant women diagnosed in hospital were selected as the experimental group, 50 healthy pregnant women as the blank group, and 50 patients with cholelithiasis as the gallstone group. Deep learning belief network (DLBN) was built by stacking multiple restricted Boltzmann machines, which was compared with the recognition rate of convolutional neural network (CNN) and support vector machine (SVM), to determine the error rate of different recognition methods on the test set. Read More

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Prevalence of preterm birth and risk factors associated with it at different gestational ages: A multicenter retrospective survey in China.

Saudi Med J 2022 Jun;43(6):599-609

From the Department of Neonatology (Zhang, Zhu Y, Zhu L, Chen, Yuan), Children's Hospital of Fudan University, from the Division of Neonatology (Lu), Gynecology and Obstetrics Hospital of Fudan University; and from the Key Laboratory of Neonatal Diseases (Chen), National Health Commission, Shanghai, China.

Objectives: To investigate the prevalence of preterm birth (PTB) and the risk factors for different gestational age subgroups of preterm birth in China.

Methods: We carried out a descriptive cross-sectional study encompassing all singleton live births (24 to 41 weeks) with completed data in 23 provinces in China from 2010 to 2017 during investigation period. We compared both the preterm group (24 to 36 weeks) and preterm subgroups (<32 weeks, 32 to 33 weeks, and 34 t0 36 weeks) with the term group (37 to 41 weeks). Read More

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Intrahepatic cholestasis of pregnancy: from an obstetrician point of view.

J Obstet Gynaecol 2022 Jun 6:1-8. Epub 2022 Jun 6.

Faculty of Business, Economic, and Accountancy, Universiti Malaysia Sabah, Kota Kinabalu, Malaysia.

Intrahepatic cholestasis of pregnancy (ICP) is the commonest among the specific dermatoses of pregnancy. The disease is characterised by intense pruritus and specifically by elevated bile acid levels and owing to the rarity of data published in this context, the disease carries a great challenge in both diagnosis and management. The disease is associated with significant maternal as well as perinatal adverse effects, hence, this article aims at improving the knowledge of the women's health carers with the up-to-date and evidence-based, whenever possible, recommendations while managing patients with ICP. Read More

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Gut microbiota in gastrointestinal diseases during pregnancy.

World J Clin Cases 2022 Apr;10(10):2976-2989

BGI-Shenzhen, Shenzhen 518083, Guangdong Province, China.

Gut microbiota (GM) is a micro-ecosystem composed of all microorganisms in the human intestine. The interaction between GM and the host plays an important role in maintaining normal physiological functions in the host. Dysbiosis of the GM may cause various diseases. Read More

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High levels of serum superoxide dismutase as a biomarker of intrahepatic cholestasis of pregnancy in patients with viral hepatitis B.

BMC Pregnancy Childbirth 2022 May 28;22(1):444. Epub 2022 May 28.

Department of Ultrasound, The First Affiliated Hospital of Xi'an Jiaotong University, Shaanxi province, Xi'an City, China.

Background: Intrahepatic cholestasis of pregnancy (ICP) is characterized by skin pruritus and impaired liver function. Hepatitis B virus (HBV) infection increases the risk of developing ICP. HBV infection is associated with oxidative stress, which has been proven to participate in the development of ICP. Read More

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Comprehensive analysis of placental gene-expression profiles and identification of EGFR-mediated autophagy and ferroptosis suppression in intrahepatic cholestasis of pregnancy.

Authors:
Yan Fang Dajun Fang

Gene 2022 Aug 25;834:146594. Epub 2022 May 25.

Department of Obstetrics and Gynecology, Guangzhou Women and Children's Medical Center, People's Republic of China. Electronic address:

Intrahepatic cholestasis of pregnancy (ICP) was the most common liver disease specific to pregnancy. The symptoms of ICP were maternal pruritus and increased bile acid level in serum which was related to preterm birth, fetal distress, meconium-stained amniotic fluid and stillbirth. However, the mechanism of ICP progression on fetal development remained obscure. Read More

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Influence of hepatitis C viral parameters on pregnancy complications and risk of mother-to-child transmission.

J Hepatol 2022 May 25. Epub 2022 May 25.

ICES, Queen's University, Kingston, Ontario, Canada; Departments of Medicine and Public Health Sciences, Queen's University, Kingston, Ontario, Canada.

Background: With the World Health Organization plan for hepatitis C elimination by the year 2030, and recent guideline recommendations to screen all women during pregnancy for HCV, data on HCV in pregnancy are needed to determine the association of HCV viremia with adverse pregnancy outcomes and mother-to-child transmission.

Methods: This is a retrospective cohort study in Ontario, Canada, using population-based administrative health care data. Individuals with HCV and pregnancy were identified and further stratified by whether they had active HCV viremia during pregnancy or resolved viremia at time of pregnancy. Read More

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Gestational cholestasis induced intrauterine growth restriction through triggering IRE1α-mediated apoptosis of placental trophoblast cells.

FASEB J 2022 07;36(7):e22388

School of Basic Medical Sciences, Anhui Medical University, Hefei, China.

Epidemiological and animal experimental studies suggest an association between gestational cholestasis and intrauterine growth restriction (IUGR). Here, we explored the mechanism through which gestational cholestasis induced IUGR. To establish gestational cholestasis model, pregnant mice were subcutaneously injected with 17α-Ethynylestradiol (E2) on gestational day 13 (GD13)-GD17. Read More

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Fetomaternal Expression of Glucose Transporters (GLUTs)-Biochemical, Cellular and Clinical Aspects.

Nutrients 2022 May 12;14(10). Epub 2022 May 12.

Department of Histology and Embryology, Poznan University of Medical Sciences, 60-701 Poznan, Poland.

Several types of specialized glucose transporters (GLUTs) provide constant glucose transport from the maternal circulation to the developing fetus through the placental barrier from the early stages of pregnancy. GLUT1 is a prominent protein isoform that regulates placental glucose transfer via glucose-facilitated diffusion. The GLUT1 membrane protein density and permeability of the syncytial basal membrane (BM) are the main factors limiting the rate of glucose diffusion in the fetomaternal compartment in physiological conditions. Read More

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Serum Exosomes MicroRNAs Are Novel Non-Invasive Biomarkers of Intrahepatic Cholestasis of Pregnancy.

Front Endocrinol (Lausanne) 2022 4;13:832577. Epub 2022 May 4.

Intensive Care Medicine, The Affiliated Wuxi No. 2 People's Hospital of Nanjing Medical University, Wuxi, China.

Background: Intrahepatic cholestasis of pregnancy (ICP) is closely related to the occurrence of adverse outcomes. Currently, total bile acids (TBAs) are the only diagnostic index for ICP, and its sensitivity and specificity have certain limitations. In this study, we aimed to develop potential biomarkers for the diagnosis of ICP. Read More

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Intrahepatic cholestasis of pregnancy and maternal dyslipidemia: a systematic review and meta-analysis.

Acta Obstet Gynecol Scand 2022 Jul 22;101(7):719-727. Epub 2022 May 22.

Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, China.

Introduction: The association between intrahepatic cholestasis of pregnancy (ICP) and maternal lipid metabolism remains unknown. This systematic review and meta-analysis aimed to evaluate the association between ICP and maternal lipid metabolism.

Material And Methods: We systematically searched Medline, Embase and the Cochrane Library (up to December 11, 2021) to identify relevant studies that investigated ICP and maternal plasma lipid concentrations. Read More

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Predictive Value of Serum Cholic Acid and Lithocholic Acid for the Diagnosis in an Intrahepatic Cholestasis of Pregnancy Population with High Levels of Total Bile Acids and the Correlation with Placental Hypoxia-Inducible Factor-1α.

Int J Womens Health 2022 9;14:687-696. Epub 2022 May 9.

Department of Obstetrics, Dongguan Eighth People's Hospital (Dongguan Children's Hospital), Dongguan, Guangdong, 523325, People's Republic of China.

Objective: This study aimed to investigate the ability of serum cholic acid (CA) and lithocholic acid (LCA) in the diagnosis and perinatal prognosis assessment of intrahepatic cholestasis of pregnancy (ICP), and the relationship between both indicators and hypoxia-inducible factor-1α (HIF-1α).

Methods: Between March 2020 and March 2021, pregnant women with high levels of total bile acid (TBA) in the late pregnancy with TBA ≥10 μmol/L and TBA <10 μmol/L (control group) were included for the retrospective study. Those with TBA ≥10 μmol/L were divided into the ICP group and the asymptomatic hypercholanaemia of pregnancy (AHP) group based on ICP symptoms. Read More

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Autophagic flux inhibition, apoptosis, and mitochondrial dysfunction in bile acids-induced impairment of human placental trophoblast.

J Cell Physiol 2022 May 17. Epub 2022 May 17.

The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Intrahepatic cholestasis of pregnancy (ICP) is a common pregnancy-specific disease, characterized by increased bile acid levels and adverse fetal outcomes. We previously reported excessive bile acids led to dysfunction of placental trophoblasts in ICP. However, the detailed mechanism is still unclear. Read More

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Az epesavmérés szerepe a súlyos terhességi cholestasis szülészeti ellátásában.

Orv Hetil 2022 May 15;163(20):797-805. Epub 2022 May 15.

1 Debreceni Egyetem, Általános Orvostudományi Kar, Szülészeti és Nőgyógyászati Intézet Debrecen, Nagyerdei krt. 98., 4032 Magyarország.

Introduction: Intrahepatic cholestasis of pregnancy complicates 1% of pregnancies. It increases the risk of severe fetal complications significantly, including preterm delivery and stillbirth.

Objective: To summarize our experience with serum total bile acid level measurement that has recently become available for clinical routine in Hungary, and to present the way of gestational cholestasis care at our university. Read More

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Fetal cardiac dysfunction in pregnancies affected by intrahepatic cholestasis of pregnancy: A cohort study.

J Obstet Gynaecol Res 2022 May 12. Epub 2022 May 12.

Fetal Medicine Unit, Department of Obstetrics and Gynecology Hospital Clínico de la Universidad de Chile, Santiago de Chile.

Aim: To analyze the presence of fetal myocardial dysfunction in intrahepatic cholestasis of pregnancy (ICP) at diagnosis.

Methods: This prospective cohort study included 49 pregnant participants with ICP at diagnosis and 49 nonaffected controls from a single public hospital. ICP was diagnosed based on clinical symptoms after excluding other causes of pruritus and presence of autoimmune diseases. Read More

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Placental Abruption and Partial Placental Prolapse During Induction of Labor in a 31-Year-Old Female With Intrahepatic Cholestasis of Pregnancy: A Case Report.

Cureus 2022 Apr 9;14(4):e23995. Epub 2022 Apr 9.

Obstetrics/Gynecology, West Suburban Medical Center, Chicago, USA.

Placental abruption during induction of labor in females with intrahepatic cholestasis of pregnancy is not exceptionally common and there are no documented reports of placental prolapse following abruption in the literature. The aim of this study is to discuss the possibility of placental abruption and partial prolapse of a low-lying placenta during a prolonged induction of labor in a female with recurrent intrahepatic cholestasis of pregnancy following a cholecystectomy. We describe a 31-year-old G4P3003 female with recurrent intrahepatic cholestasis of pregnancy, with no family history of the condition and surgical history of cholecystectomy, whose induction of labor at 37+3/7 gestational weeks for intrahepatic cholestasis of pregnancy was complicated by placental abruption and partial prolapse of the low-lying placenta. Read More

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Serum Bile Acid Levels in Women With Intrahepatic Cholestasis of Pregnancy in India.

J Clin Exp Hepatol 2022 Mar-Apr;12(2):379-383. Epub 2021 Jul 20.

Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India.

Introduction: Intrahepatic cholestasis of pregnancy (ICP) manifests as unexplained intense pruritus in the third trimester of pregnancy and is often diagnosed based on elevated serum bile acid measurement. There are no data from India on serum bile acid levels in pregnant women with ICP.

Methods: Pregnant women with significant pruritus during the third trimester of gestation and with elevated serum alanine aminotransferase and/or aspartate aminotransferase (normal: <40 IU/L) were taken as having ICP. Read More

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A New Variant of an Old Itch: Novel Missense Variant in Presenting with Intractable Pruritus.

J Clin Exp Hepatol 2022 Mar-Apr;12(2):701-704. Epub 2021 Apr 29.

Aster Integrated Liver Care, Aster CMI Hospital, Bangalore, India.

We report a novel homozygous missense variant in  gene in a Yemeni child born to consanguineous parents, with a significant family history of liver disease-related deaths, resulting in a progressive familial intrahepatic cholestasis (PFIC) type 3 phenotype requiring liver transplantation for intractable pruritus. Read More

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A Case of Markedly Elevated Isolated Alkaline Phosphatase in the Third Trimester of Pregnancy.

Case Rep Obstet Gynecol 2022 27;2022:1611304. Epub 2022 Apr 27.

Department of Obstetrics, Gynecology and Reproductive Science, Icahn School of Medicine at Mount Sinai, New York City, USA.

Background: Alkaline phosphatase (ALP) is an enzyme produced by the liver, small intestine, bone, and kidneys as well as the placenta during pregnancy. ALP levels may increase up to twice the normal limit during pregnancy secondary to placental release and fetal bone growth. Rare case reports of extremely elevated levels of ALP during pregnancy have demonstrated possible association with adverse pregnancy outcomes. Read More

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Effect of Levothyroxine on Pregnancy Outcomes in Pregnant Women With Hypothyroxinemia: An Interventional Study.

Front Endocrinol (Lausanne) 2022 19;13:874975. Epub 2022 Apr 19.

Department of Obstetrics, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, China.

Context: Adverse maternal outcomes and perinatal complications are associated with maternal hypothyroidism. However, the utility of levothyroxine (L-T4) in the treatment of pregnant women with hypothyroxinemia is unclear.

Objective: This study aimed to evaluate the effects of L-T4 on maternal and perinatal outcomes in pregnant women with hypothyroxinemia. Read More

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Impact of hepatitis B virus infection on maternal and infant outcomes of women with gestational diabetes mellitus: A three-year retrospective study.

J Diabetes Complications 2022 Jun 20;36(6):108201. Epub 2022 Apr 20.

School of Nursing, Wuhan University, No.115, Donghu Road, Wuchang District, Wuhan, 430071, Hubei Province, China. Electronic address:

Aims: To explore the impact of HBV infection on maternal and infant outcomes of GDM women.

Methods: We retrospectively identified 8126 women with GDM in China from July 2017 to June 2020, and divided them into GDM with HBV infection group (n = 483) and GDM with non-HBV infection group (n = 7643). Two sample t-test and Chi-square test were used to compare differences between groups. Read More

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Role of Vitamin B12 and Vitamin D levels in intrahepatic cholestasis of pregnancy and correlation with total bile acid.

J Obstet Gynaecol 2022 Apr 28:1-6. Epub 2022 Apr 28.

Department of Obstetrics and Gynecology, Tinaztepe University, Izmir, Turkey.

This study aimed to evaluate the relationship between intrahepatic cholestasis of pregnancy (ICP) and Vitamin D and B12 levels. The study was a retrospective, cross-sectional, case-control study that evaluated 92 ICP cases and 102 pregnant women without any additional disease. ICP cases were grouped as mild and severe according to their total bile acid (TBA) levels, and their relationship with Vitamin D and B12 levels and perinatal outcomes was evaluated. Read More

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Identification of two novel pathogenic variants of the NR1H4 gene in intrahepatic cholestasis of pregnancy patients.

BMC Med Genomics 2022 04 18;15(1):90. Epub 2022 Apr 18.

Key Laboratory of Women's Reproductive Health of Jiangxi Province, Jiangxi Provincial Maternal and Child Health Hospital, Nanchang, 330006, Jiangxi, China.

Background: Intrahepatic cholestasis of pregnancy (ICP) can cause adverse pregnancy outcomes, such as spontaneous preterm delivery and stillbirth. It is a complex disease influenced by multiple factors, including genetics and the environment. Previous studies have reported that functioning nuclear receptor subfamily 1 group H member 4 (NR1H4) plays an essential role in bile acid (BA) homeostasis. Read More

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Multidrug Resistance-Associated Protein 2 Deficiency Aggravates Estrogen-Induced Impairment of Bile Acid Metabolomics in Rats.

Front Physiol 2022 21;13:859294. Epub 2022 Mar 21.

Department of Pharmacology, Faculty of Medicine in Hradec Kralove, Charles University, Hradec Kralove, Czechia.

Multidrug resistance-associated protein 2 (Mrp2) mediates biliary secretion of anionic endobiotics and xenobiotics. Genetic alteration of Mrp2 leads to conjugated hyperbilirubinemia and predisposes to the development of intrahepatic cholestasis of pregnancy (ICP), characterized by increased plasma bile acids (BAs) due to mechanisms that are incompletely understood. Therefore, this study aimed to characterize BA metabolomics during experimental Mrp2 deficiency and ICP. Read More

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Intrahepatic cholestasis of pregnancy - Time to redefine the reference range of total serum bile acids: A cross-sectional study.

BJOG 2022 Apr 4. Epub 2022 Apr 4.

Obstetrics and Gynaecology Unit, Department of Health Sciences, University of Florence, Florence, Italy.

Objective: To establish pregnancy-specific reference ranges for fasting and postprandial total serum bile acid (TSBA) concentrations.

Design: Cross-sectional study.

Setting: Tertiary-care university hospital. Read More

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Navigating Uncertainty: A Case Study of Intrahepatic Cholestasis of Pregnancy.

J Midwifery Womens Health 2022 May 4;67(3):398-402. Epub 2022 Apr 4.

Capital Health, Trenton, New Jersey.

Intrahepatic cholestasis of pregnancy (ICP), the most common liver disorder of pregnancy, is associated with complications for both a pregnant person and their fetus. The underlying cause is not well understood. The pruritus associated with ICP is uncomfortable for pregnant people; however, the primary concern is the fetal risk. Read More

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