33,589 results match your criteria Intractable Plantar Keratosis


Long-term seizure outcome in frontal lobe epilepsy surgery.

Epilepsy Behav 2018 Dec 3;90:93-98. Epub 2018 Dec 3.

IRCCS "NEUROMED", Pozzilli, IS, Italy; Department of Neurology and Psychiatry, "Sapienza" University of Rome, Italy.

Purpose: The purpose of this study was to report long-term seizure outcome in patients who underwent frontal lobe epilepsy (FLE) surgery.

Method: This retrospective study included 44 consecutive subjects who underwent resective surgery for intractable FLE at IRCCS NEUROMED (period 2001-2014), followed up for at least 2 years (mean: 8.7 years). Read More

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December 2018
2 Reads

Faecal incontinence: investigation, treatment and management.

Authors:
Linda Nazarko

Br J Community Nurs 2018 Dec;23(12):582-588

Consultant nurse, physical healthcare, West London Mental Health Trust.

Faecal incontinence (FI) is a hidden problem that is under-diagnosed, under-investigated and under treated. Up to 10% of adults can experience an episode of FI. The prevalence of FI in the adult population has been estimated at 0. Read More

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December 2018
2 Reads

Accurate and efficient estimation of small p-values with the cross-entropy method: applications in genomic data analysis.

Bioinformatics 2018 Dec 6. Epub 2018 Dec 6.

Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, USA.

Motivation: Small p-values are often required to be accurately estimated in large-scale genomic studies for the adjustment of multiple hypothesis tests and the ranking of genomic features based on their statistical significance. For those complicated test statistics whose cumulative distribution functions are analytically intractable, existing methods usually do not work well with small p-values due to lack of accuracy or computational restrictions. We propose a general approach for accurately and efficiently estimating small p-values for a broad range of complicated test statistics based on the principle of the cross-entropy method and Markov chain Monte Carlo sampling techniques. Read More

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December 2018
1 Read

Resolving Deep Nodes in an Ancient Radiation of Neotropical Fishes in the Presence of Conflicting Signals from Incomplete Lineage Sorting.

Syst Biol 2018 Dec 6. Epub 2018 Dec 6.

Museum of Natural Science, Department of Biological Sciences, Louisiana State University, Baton Rouge, Louisiana, USA.

Resolving patterns of ancient and rapid diversifications is one of the most challenging tasks in evolutionary biology. These difficulties arise from confusing phylogenetic signals that are associated with the interplay of incomplete lineage sorting and homoplasy. Phylogenomic analyses of hundreds, or even thousands, of loci offer the potential to resolve such contentious relationships. Read More

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December 2018

Eomes-expressing T-helper cells as potential target of therapy in chronic neuroinflammation.

Authors:
Shinji Oki

Neurochem Int 2018 Nov 30. Epub 2018 Nov 30.

Department of Immunology, National Institute of Neuroscience, National Center of Neurology and Psychiatry (NCNP), 4-1-1 Ogawahigashi, Kodaira, Tokyo, 187-8502, Japan. Electronic address:

Reserch progresses in understanding the pathogenicity of multiple sclerosis (MS) in the last couple of decade has enabled us to develop new drug entities available in the clinic. However, we still have not succeeded in preventing conversion from relapsing-remitting MS (RR-MS) to secondary progressive MS (SP-MS) and curing this intractable form of MS. Furthermore, diagnosis is usually retrospective and subjective, relying on gradual worsening of neurological signs/symptoms. Read More

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November 2018

Transformation of Recurrent Respiratory Papillomatosis: Squamous Cell Carcinoma in a Pregnant Teen.

Ann Thorac Surg 2018 Nov 30. Epub 2018 Nov 30.

Department of Cardiothoracic Surgery, Heart and Vascular Institute, Cleveland Clinic. Cleveland. Ohio. United States. Electronic address:

Recurrent Respiratory Papillomatosis (RRP) is a rare intractable benign disease with a bimodal age distribution. We present a rare case of malignant transformation of juvenile-onset RRP in a 19-year old pregnant female, who was found to have a right upper lobe mass and cavitary nodules bilaterally that were biopsy proven to be node negative, multifocal squamous cell carcinoma. In her second trimester, she underwent Video Assisted Thoracoscopic (VATS) right upper lobectomy and middle lobe lateral segmentectomy, followed by left lower lobe segmentectomy nine months later. Read More

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November 2018

Intravenous Lidocaine Administered as Twice Daily Bolus and Continuous Infusion for Intractable Cancer Pain and Wound Care Pain.

J Palliat Med 2018 Dec 1. Epub 2018 Dec 1.

3 Spectrum Health Medical Group , Palliative Care Medicine, Grand Rapids, Michigan.

Introduction: Intravenous lidocaine is an option for intractable pain caused by advancing cancer and wound care. We report a case of intractable cancer pain and wound care pain managed with concurrent use of lidocaine administered as a twice daily intravenous bolus in addition to continuous intravenous infusion.

Case Description: A 31-year-old male with rapidly progressing locally advanced squamous cell cancer affecting the gluteal area developed extensive painful and purulent ulcerating wounds affecting the coccyx, superior gluteal cleft, and buttocks. Read More

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December 2018
2 Reads

Atypical calcific tendinitis involving the long biceps tendon: A rare cause of hemiplegic shoulder pain.

J Back Musculoskelet Rehabil 2018 Nov 23. Epub 2018 Nov 23.

Department of Rehabilitation Medicine, Daegu Veterans Health Service Medical Center, Daegu, Korea.

Background And Objective: Calcific tendinitis is commonly found in the rotator cuff; however, it is very rare in the long biceps tendon (LBT). Furthermore, calcific tendinitis involving the LBT in the hemiplegic shoulder after a stroke has not been previously reported.

Materials And Method: We present a case of a 63-year-old man who suffers from a stroke and atypical calcific tendinitis involving the LBT as a rare cause of hemiplegic shoulder pain. Read More

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November 2018
1 Read

Scalable Large-Margin Distance Metric Learning Using Stochastic Gradient Descent.

IEEE Trans Cybern 2018 Nov 29. Epub 2018 Nov 29.

The key to success of many machine learning and pattern recognition algorithms is the way of computing distances between the input data. In this paper, we propose a large-margin-based approach, called the large-margin distance metric learning (LMDML), for learning a Mahalanobis distance metric. LMDML employs the principle of margin maximization to learn the distance metric with the goal of improving k-nearest-neighbor classification. Read More

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November 2018

Effects of Tonic Spinal Cord Stimulation on Sensory Perception in Chronic Pain Patients: A Systematic Review.

Neuromodulation 2018 Dec 2. Epub 2018 Dec 2.

Centre de recherche du CHU de Québec - Université Laval, Axe neurosciences, Quebec city, Quebec, Canada.

Objectives: Even if spinal cord stimulation (SCS) is widely used and effective in treating intractable chronic neuropathic pain conditions, little is known about its possible impacts on sensory perception. Quantitative sensory testing (QST) is a useful tool to assess this issue. The aim of this study was to review the impact of tonic SCS on somatosensory perception quantified by QST in chronic pain patients. Read More

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December 2018

Recent Advances in Oligonucleotide-Based Therapy for Transthyretin Amyloidosis: Clinical Impact and Future Prospects.

Biol Pharm Bull 2018 ;41(12):1737-1744

Department of Pharmacy, Kumamoto University Hospital.

Transthyretin (TTR) amyloidosis, also known as transthyretin-related familial amyloidotic polyneuropathy (ATTR-FAP), is a fatal hereditary systemic amyloidosis caused by mutant forms of TTR. Although conventional treatments for ATTR-FAP, such as liver transplantation (LT) and TTR tetramer stabilizer, reportedly halt the progression of clinical manifestation, these therapies have several limitations. Oligonucleotide-based therapy, e. Read More

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January 2018

Pathogenic Variants in Fucokinase Cause a Congenital Disorder of Glycosylation.

Am J Hum Genet 2018 Nov 21. Epub 2018 Nov 21.

Human Genetics Program, Sanford-Burnham-Prebys Medical Discovery Institute, La Jolla, CA 92037, USA. Electronic address:

FUK encodes fucokinase, the only enzyme capable of converting L-fucose to fucose-1-phosphate, which will ultimately be used for synthesizing GDP-fucose, the donor substrate for all fucosyltransferases. Although it is essential for fucose salvage, this pathway is thought to make only a minor contribution to the total amount of GDP-fucose. A second pathway, the major de novo pathway, involves conversion of GDP-mannose to GDP-fucose. Read More

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November 2018

Evaluation of a dual signal subspace projection algorithm in magnetoencephalographic recordings from patients with intractable epilepsy and vagus nerve stimulators.

Neuroimage 2018 Nov 28. Epub 2018 Nov 28.

Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, 94143-0628, USA; Department of Neurology, University of California, San Francisco, CA 94143-0628, USA. Electronic address:

Magnetoencephalography (MEG) data is subject to many sources of environmental noise, and interference rejection is a necessary step in the processing of MEG data. Large amplitude interference caused by sources near the brain have been both common in clinical settings and difficult to reject. Artifacts from vagal nerve stimulators (VNS) are a common and difficult example. Read More

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November 2018
1 Read

Altered A-Type Potassium Channel Function in the Nucleus Tractus Solitarius in Acquired Temporal Lobe Epilepsy.

J Neurophysiol 2018 Dec 5. Epub 2018 Dec 5.

Neuroscience, University of Kentucky College of Medicine, United States.

Sudden unexpected death in epilepsy (SUDEP) is among the leading causes of death in people with epilepsy. Individuals with temporal lobe epilepsy (TLE) have a high risk for SUDEP because the seizures are often medically intractable. Neurons in the nucleus tractus solitarius (NTS) have been implicated in mouse models of SUDEP and play a critical role in modulating cardiorespiratory and autonomic output. Read More

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December 2018
1 Read

Motion preservation surgery: excision of juxta C5-C6 intervertebral disc osteoid osteoma using 3D C-arm based navigation: technical report.

SICOT J 2018 5;4:56. Epub 2018 Dec 5.

Mumbai Spine Scoliosis & Disc Replacement Centre, Bombay Hospital & Medical Research Center, Marine Lines, Mumbai 400002, India.

Introduction: Precise targeted excision of the C5-C6 osteoid osteoma with placement of reference array on clavicle with minimal disturbance of anatomy and motion.

Methods: A 20-year-old male presented with an osteoid osteoma in the superior end plate of the C6 vertebra abutting the spinal canal causing intractable pain. The authors curetted the nidus using a 3D C-arm-based intraoperative scan integrated with an optical navigation system through a minimal access anterior cervical exposure. Read More

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December 2018

Automated Affect Detection in Deep Brain Stimulation for Obsessive-Compulsive Disorder: A Pilot Study.

Proc ACM Int Conf Multimodal Interact 2018 Oct;2018:40-44

Baylor College of Medicine, Houston, Texas.

Automated measurement of affective behavior in psychopathology has been limited primarily to screening and diagnosis. While useful, clinicians more often are concerned with whether patients are improving in response to treatment. Are symptoms abating, is affect becoming more positive, are unanticipated side effects emerging? When treatment includes neural implants, need for objective, repeatable biometrics tied to neurophysiology becomes especially pressing. Read More

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October 2018

Coronary spasm: It's common, but it's still unsolved.

World J Cardiol 2018 Nov;10(11):201-209

Department of Cardiovascular Medicine, JR Hiroshima Hospital, Hiroshima 732-0057, Japan.

Coronary spasm is caused by a transient coronary narrowing due to the constriction of epicardial coronary artery, which leads to myocardial ischemia. More than 50 years have passed since the first recognition of coronary spasm, and many findings on coronary spasm have been reported. Coronary spasm has been considered as having pivotal roles in the cause of not only rest angina but also exertional angina, acute coronary syndrome, and heart failure. Read More

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November 2018

Efficacy and safety of CT-guided percutaneous pulsed radiofrequency treatment of the Gasserian ganglion in patients with medically intractable idiopathic trigeminal neuralgia.

J Pain Res 2018 19;11:2877-2885. Epub 2018 Nov 19.

Department of Anesthesiology and Pain Management, Beijing Tiantan Hospital, Capital Medical University, Beijing, PR China,

Background: There is a lack of prospective studies for the long-term results of percutaneous pulsed radiofrequency (PRF) of the Gasserian ganglion in the treatment of patients with medically refractory trigeminal neuralgia (TN).

Methods And Results: We prospectively observed the outcomes of 28 idiopathic TN patients (between July 2013 and July 2016) who received CT-guided percutaneous PRF treatment of the Gasserian ganglion. All of the patients had stopped responding to drug therapy before PRF treatment. Read More

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November 2018

The RNA Base-Pairing Problem and Base-Pairing Solutions.

Cold Spring Harb Perspect Biol 2018 Dec 3;10(12). Epub 2018 Dec 3.

Center for Personal Dynamic Regulomes, Stanford University, Stanford, California 94305.

SUMMARYRNA molecules are folded into structures and complexes to perform a wide variety of functions. Determination of RNA structures and their interactions is a fundamental problem in RNA biology. Most RNA molecules in living cells are large and dynamic, posing unique challenges to structure analysis. Read More

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December 2018

A Novel Technique of Saddle Rhizotomy Using Thermal Radiofrequency for Intractable Perineal Pain in Pelvic Malignancy: A Pilot Study.

Pain Physician 2018 Nov;21(6):E651-E660

Department of Anesthesia and Pain Management, National Cancer Institute, Cairo University, Cairo, Egypt.

Background: The prevalence of pain in advanced pelvic cancer may reach up to 95%. Control of such pain is often difficult owing to a variety of neuroanatomical and functional peculiarities. Different modalities have been utilized to treat this pain including saddle chemical rhizolysis with the potential for jeopardizing the neural control of the sphincters. Read More

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November 2018
1 Read

Simultaneous scalp EEG improves seizure lateralization during unilateral intracranial EEG evaluation in temporal lobe epilepsy.

Seizure 2018 Nov 24;64:8-15. Epub 2018 Nov 24.

Department of Neurology, Baylor College of Medicine, Houston, TX 77030, United States; Neurology care line, VA Houston Medical Center, Houston, TX 77030, United States.

Purpose: To determine if simultaneous bilateral scalp EEG (scEEG) can accurately detect a contralateral seizure onset in patients with unilateral intracranial EEG (IEEG) implantation.

Methods: We evaluated 39 seizures from 9 patients with bitemporal epilepsy who underwent simultaneous scEEG and IEEG (SSIEEG). To simulate conditions of unilateral IEEG implantation with a missed contralateral seizure onset, we analyzed the IEEG recording contralateral to the seizure onset (CL- IEEG), in conjunction with simultaneous scEEG. Read More

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November 2018

Yield of laboratory testing in pediatric ketogenic diet patients: Critical assessment of abnormal results and impact on clinical care.

Epilepsy Res 2018 Nov 16;149:70-75. Epub 2018 Nov 16.

Children's Hospital of Colorado- Dietary Division, United States.

Objectives: To retrospectively assess the incidence of high beta hydroxybutyrate, low bicarbonate (BIC), high acyl carnitine, low selenium, low magnesium, low zinc, low phosphorus, in a cohort of supplemented patients treated with the ketogenic diet (KD) for medically intractable epilepsy. To analyze effect of age, duration of exposure to KD, type of KD, and route of KD intake on lab abnormalities. To analyze the incidence of clinically actionable results, resulting in medical interventions based on abnormal results and to analyze costs of testing. Read More

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November 2018
1 Read

Lafora Disease Masquerading as Hepatic Dysfunction.

Cureus 2018 Aug 24;10(8):e3197. Epub 2018 Aug 24.

Internal Medicine, University of South Dakota Sanford School of Medicine, Sioux Falls, USA.

Lafora disease is fatal intractable progressive myoclonic epilepsy. It is frequently characterized by epileptic seizures, difficulty walking, muscle spasms, and dementia in late childhood or adolescence. We chronicle here an unusual case of an asymptomatic young male soccer player who presented with elevated liver enzymes. Read More

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Recombinant activated factor VII (rFVIIa) in refractory haemorrhage for non-haemophiliacs: an eleven-year single-centre experience.

BMC Hematol 2018 23;18:34. Epub 2018 Nov 23.

1Regenerative Medicine Cluster, Advanced Medical and Dental Institute, Universiti Sains Malaysia, 13200 Kepala Batas, PNG Malaysia.

Background: Massive bleeding is one of the commonest salvageable causes of death. The search for an ideal haemostatic agent during massive bleeding is still ongoing. One of the novel haemostatic medications is recombinant activated factor VII (rFVIIa). Read More

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November 2018
4 Reads

Understanding key drivers of performance in the provision of maternal health services in eastern cape, South Africa: a systems analysis using group model building.

BMC Health Serv Res 2018 Nov 29;18(1):912. Epub 2018 Nov 29.

Mailman School of Public Health, Columbia University, New York, USA.

Background: The Eastern Cape Province reports among the poorest health service indicators in South Africa with some of its districts standing out as worst performing as regards maternal health indicators. To understand key drivers and outcomes of this underperformance and to explore whether a participatory analysis could deepen action-oriented understanding among stakeholders, a study was conducted in one of the chronically poorly performing districts.

Methods: The study used a systems analysis approach to understand the drivers and outcomes affecting maternal health in the district in order to identify key leverage points for addressing the situation. Read More

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November 2018
1 Read

Surgical outcomes for medically intractable epilepsy in low- and middle-income countries: a systematic review and meta-analysis.

Authors:

J Neurosurg 2018 Nov 1:1-11. Epub 2018 Nov 1.

OBJECTIVEThe aim of this study was to describe the current state of epilepsy surgery and establish estimates of seizure outcomes following surgery for medically intractable epilepsy (MIE) in low- and middle-income countries (LMICs).METHODSThe MEDLINE and Embase databases were searched without publication date restriction. This search was supplemented by a manual screen of key epilepsy and neurosurgical journals (January 2005 to December 2016). Read More

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November 2018

International Stakeholder Community of Pain Experts and Leaders Call for an Urgent Action on Forced Opioid Tapering.

Authors:
Beth D Darnall David Juurlink Robert D Kerns Sean Mackey Brent Van Dorsten Keith Humphreys Julio A Gonzalez-Sotomayor Andrea Furlan Adam J Gordon Debra B Gordon Diane E Hoffman Joel Katz Stefan G Kertesz Sally Satel Richard A Lawhern Kate M Nicholson Rosemary C Polomano Owen D Williamson Heath McAnally Ming-Chih Kao Stephan Schug Robert Twillman Terri A Lewis Richard L Stieg Kate Lorig Theresa Mallick-Searle Robert W West Sarah Gray Steven R Ariens Jennifer Sharpe Potter Penney Cowan Chad D Kollas Danial Laird Barby Ingle J Julian Grove Marian Wilson Kashelle Lockman Fiona Hodson Carol S Palackdharry Roger B Fillingim Jeffrey Fudin Jennifer Barnhouse Ajay Manhapra Steven R Henson Bruce Singer Marie Ljosenvoor Marlisa Griffith Jason N Doctor Kimeron Hardin Cathleen London Jon Mankowski Andrea Anderson Linda Ellsworth Lisa Davis Budzinski Becky Brandt Greg Harkootley Debbie Nickels Heck Mark J Zobrosky Celeste Cheek Megan Wilson Cynthia E Laux Geralyn Datz Justin Dunaway Eileen Schonfeld Melissa Cady Thérèse LeDantec-Boswell Meredith Craigie John Sturgeon Pamela Flood Melita Giummarra Jessica Whelan Beverly E Thorn Richard L Martin Michael E Schatman Maurice D Gregory Joshua Kirz Patti Robinson James G Marx Jessica R Stewart Phillip S Keck Scott E Hadland Jennifer L Murphy Mark A Lumley Kathleen S Brown Michael S Leong Mechele Fillman James W Broatch Aaron Perez Kristine Watford Kari Kruska Dokyoung Sophia You Stacy Ogbeide Amy Kukucka Susan Lawson James B Ray T Wade Martin James B Lakehomer Anne Burke Robert I Cohen Peter Grinspoon Marc S Rubenstein Stephani Sutherland Kristie Walters Travis Lovejoy

Pain Med 2018 Nov 29. Epub 2018 Nov 29.

Department of Psychiatry, Oregon Health & Science University, Portland, Oregon.

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November 2018
1 Read
2.300 Impact Factor

AIMMS suite: a web server dedicated for prediction of drug resistance on protein mutation.

Brief Bioinform 2018 Nov 29. Epub 2018 Nov 29.

Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan, P.R. China.

Drug resistance is one of the most intractable issues for successful treatment in current clinical practice. Although many mutations contributing to drug resistance have been identified, the relationship between the mutations and the related pharmacological profile of drug candidates has yet to be fully elucidated, which is valuable both for the molecular dissection of drug resistance mechanisms and for suggestion of promising treatment strategies to counter resistant. Hence, effective prediction approach for estimating the sensitivity of mutations to agents is a new opportunity that counters drug resistance and creates a high interest in pharmaceutical research. Read More

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November 2018
1 Read

A novel use of intratympanic dexamethasone for intractable posterior canal benign paroxysmal positional vertigo: report of two cases.

Authors:
A Kelkar I Johnson

J Laryngol Otol 2018 Nov 29:1-3. Epub 2018 Nov 29.

Department of ENT,Newcastle upon Tyne Hospitals NHS Foundation Trust,UK.

Background: Benign paroxysmal positional vertigo is a common inner-ear pathology, characterised by episodic vertigo lasting for a few seconds that is associated with sudden change in the head position. Benign paroxysmal positional vertigo is treated with canalolith repositioning manoeuvres. Intractable vertigo describes a small group of patients who either do not improve with canalolith repositioning manoeuvres (persistent cases) or who relapse after improvement of initial symptoms (recurrent cases). Read More

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November 2018

Hypoxia potentiates gemcitabine-induced stemness in pancreatic cancer cells through AKT/Notch1 signaling.

J Exp Clin Cancer Res 2018 Nov 28;37(1):291. Epub 2018 Nov 28.

Department of Pancreatic Surgery, Renmin Hospital, Wuhan University, 238 Jiefang Road, Wuhan, 430060, Hubei Province, China.

Background: Profound chemoresistance remains an intractable obstacle in pancreatic cancer treatment. Pancreatic cancer stem cells (CSCs) and the ubiquitous hypoxic niche have been proposed to account for drug resistance. However, the mechanism involved requires further exploration. Read More

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November 2018

Clinical characteristics of pyogenic spondylitis and psoas abscess at a tertiary care hospital: a retrospective cohort study.

J Orthop Surg Res 2018 Nov 28;13(1):302. Epub 2018 Nov 28.

Department of Pediatrics, Shimane Prefectural Central Hospital, Izumo, Japan.

Background: Psoas abscess and pyogenic spondylitis are intractable diseases that require long-term treatment, but the clinical characteristics and causative organisms have not been fully investigated. Herein, we describe the clinical characteristics of these diseases and evaluate the factors associated with in-hospital mortality and the presence of gram-negative rods as causative microorganisms.

Methods: All patients diagnosed with pyogenic spondylitis or psoas abscesses at a tertiary hospital were included. Read More

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November 2018

Helmsman: fast and efficient mutation signature analysis for massive sequencing datasets.

BMC Genomics 2018 Nov 28;19(1):845. Epub 2018 Nov 28.

Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA.

Background: The spectrum of somatic single-nucleotide variants in cancer genomes often reflects the signatures of multiple distinct mutational processes, which can provide clinically actionable insights into cancer etiology. Existing software tools for identifying and evaluating these mutational signatures do not scale to analyze large datasets containing thousands of individuals or millions of variants.

Results: We introduce Helmsman, a program designed to perform mutation signature analysis on arbitrarily large sequencing datasets. Read More

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November 2018
3.986 Impact Factor

Coagulation Pathways, Hemostasis, and Thrombosis in Liver Failure.

Semin Respir Crit Care Med 2018 Oct 28;39(5):598-608. Epub 2018 Nov 28.

Division of Gastroenterology and Hepatology, Department of Medicine, Center for Coagulation in Liver Disease, University of Virginia School of Medicine, Charlottesville, Virginia.

Achieving hemostasis, preventing and treating thrombosis, and laboratory measurement of the hemostatic pathways constitute the core elements of managing the critically ill patient with liver failure. Uncontrolled bleeding in acutely decompensated cirrhosis and acute-on-chronic liver failure is probably the most familiar clinical challenge to intensivists. Bleeding in these patients can be broadly divided into pressure-driven (portal hypertension-related) bleeding with only limited dependence on hemostatic pathways and intractable mucosal/wound bleeding, which is much more directly related to a severely disturbed hemostatic system with imbalances in the coagulation cascade and the fibrinolytic system. Read More

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October 2018
2 Reads

Language lateralization with resting-state and task-based functional MRI in pediatric epilepsy.

Authors:

J Neurosurg Pediatr 2018 Oct 1:1-7. Epub 2018 Oct 1.

OBJECTIVEDetermining language laterality in patients with intractable epilepsy is important in operative planning. Wada testing is the gold standard, but it has a risk of stroke. Both Wada and task-based functional MRI (tb-fMRI) require patient cooperation. Read More

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October 2018

Bringing ALife and Complex Systems Science to Population Health Research.

Authors:
Eric Silverman

Artif Life 2018 ;24(3):220-223

University of Glasgow, MRC/CSO Social and Public Health Sciences Unit.

Despite tremendous advancements in population health in recent history, human society currently faces significant challenges from wicked health problems. These are problems where the causal mechanisms at play are obscured and difficult to address, and consequently they have defied efforts to develop effective interventions and policy solutions using traditional population health methods. Systems-based perspectives are vital to the development of effective policy solutions to seemingly intractable health problems like obesity and population aging. Read More

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January 2018

The association of changes in RAD51 and survivin expression levels with the proton beam sensitivity of Capan‑1 and Panc‑1 human pancreatic cancer cells.

Int J Oncol 2018 Nov 22. Epub 2018 Nov 22.

Department of Pharmacology and Intractable Disease Research Center, School of Medicine, Dongguk University, Gyeongju, Gyeongsanbuk-do 38066, Republic of Korea.

Fewer than 20% of patients diagnosed with pancreatic cancer can be treated with surgical resection. The effects of proton beam irradiation were evaluated on the cell viabilities in Panc‑1 and Capan‑1 pancreatic cancer cells. The cells were irradiated with proton beams at the center of Bragg peaks with a 6‑cm width using a proton accelerator. Read More

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November 2018
1 Read

Roll-Back Eradication of Bovine Tuberculosis (TB) From Wildlife in New Zealand: Concepts, Evolving Approaches, and Progress.

Front Vet Sci 2018 12;5:277. Epub 2018 Nov 12.

OSPRI, Christchurch, New Zealand.

The New Zealand government and agricultural industries recently jointly adopted the goal of nationally eradicating bovine tuberculosis (TB) from livestock and wildlife reservoirs by 2055. Only Australia has eradicated TB from a wildlife maintenance host. Elsewhere the disease is often self-sustaining in a variety of wildlife hosts, usually making eradication an intractable problem. Read More

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November 2018
1 Read

Immunotherapy and Epigenetic Pathway Modulation in Glioblastoma Multiforme.

Front Oncol 2018 13;8:521. Epub 2018 Nov 13.

Department of Psychiatry and Behavioral Sciences, Center for Therapeutic Innovation, Sylvester Comprehensive Cancer Center, Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, FL, United States.

Glioblastoma Multiforme (GBM) is the most common malignant primary brain tumor. Despite aggressive multimodality treatment it remains one of the most challenging and intractable cancers (1]. While current standard of care treatment for GBM is maximal safe surgical resection, systemic chemotherapy with Temozolimide (TMZ), and radiation therapy, the current prognosis of GBM patients remains poor, with a median overall survival of 12-15 months (2, 3). Read More

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November 2018
1 Read

Generation of motor neurons from human amygdala-derived neural stem-like cells.

Iran J Basic Med Sci 2018 Nov;21(11):1155-1160

Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran.

Objectives: Among several cell sources, adult human neural stem/progenitor cells (hNS/PCs) have been considered outstanding cells for performing mechanistic studies in in vitro and in vivo models of neurological disorders as well as for potential utility in cell-based therapeutic approaches. Previous studies addressed the isolation and culture of hNS/PCs from human neocortical and hippocampal tissues. However, little data are available on hNS/PCs obtained from the adult human amygdala. Read More

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November 2018

Recent Advances in Drug Delivery System for Bioactive Glycosides from Traditional Chinese Medicine.

Am J Chin Med 2018 Nov 27:1-34. Epub 2018 Nov 27.

* School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, P. R. China.

Traditional Chinese Medicine (TCM) has been used in China for thousands of years for the prevention and treatment of various diseases. The materials that exert a therapeutic effect are called the active ingredients. The bioactive glycosides are important active ingredients from TCM that can make significant contributions to treating diseases. Read More

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November 2018
2.625 Impact Factor

Sjögren's Syndrome, Non-Sjögren's Syndrome, and Graft-Versus-Host Disease Related Dry Eye.

Authors:
Yoko Ogawa

Invest Ophthalmol Vis Sci 2018 Nov;59(14):DES71-DES79

Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan.

I have reviewed available literature on dry eye related to Sjögren's syndrome (SS), non-Sjögren's syndrome (non-SS), and graft-versus-host disease (GVHD) to examine aqueous tear deficient dry eye as a subtype of dry eye. This section will focus on clinical studies regarding those subtypes of dry eye. I searched the PubMed database from 1990-2017 for discussion of clinical features, diagnostic criteria, and risk factors of SS, non-SS, and GVHD-related dry eye. Read More

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November 2018

Synthetic biology approaches in immunology.

Biochemistry 2018 Nov 27. Epub 2018 Nov 27.

Breakthroughs in gene synthesis has allowed synthetic biologists the ability to design any DNA sequence of interest, enabling the possibility to create complex systems inside cells with novel functions to tackle problems in immunology. Synthetic immunology of mammalian cells expressing natural or synthetic genes can guide and induce immune responses in patients. Through recent developments in engineering chimeric receptors, it is now feasible to customize control over engineered cells to target the disease sites with specificity. Read More

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November 2018

Increased end-stage renal disease risk in patients with inflammatory bowel disease: A nationwide population-based study.

World J Gastroenterol 2018 Nov;24(42):4798-4808

Department of Internal Medicine, Liver Research Institute, Seoul National University College of Medicine, Seoul 03080, South Korea.

Aim: To estimate the risk of end-stage renal disease (ESRD) in patients with inflammatory bowel disease (IBD).

Methods: From January 2010 to December 2013, patients with Crohn's disease (CD) and ulcerative colitis (UC) were identified, based on both the International Classification of Diseases, 10 revision (ICD-10) and the rare, intractable disease registration program codes from the National Health Insurance (NHI) database in South Korea. We compared 38812 patients with IBD to age- and sex-matched non-IBD controls with a ratio of 1:3. Read More

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November 2018
1 Read

Monitoring treatment response to tafamidis by serial native T1 and extracellular volume in transthyretin amyloid cardiomyopathy.

ESC Heart Fail 2018 Nov 27. Epub 2018 Nov 27.

Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, Osaka, Japan.

Tafamidis meglumine, a transthyretin (TTR) stabilizer, is effective in delaying the progression of neuropathy in TTR amyloidosis with Val30Met mutations. However, its efficacy in TTR amyloid cardiomyopathy is not fully elucidated. Herein, we report a 73-year-old Japanese man with a diagnosis of TTR amyloid cardiomyopathy with Val30Met mutation treated with tafamidis. Read More

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November 2018
3 Reads

Intractable itch in a Brazilian expatriate.

J Travel Med 2018 Nov 22. Epub 2018 Nov 22.

School of Medicine, National University of Ireland Galway, Galway, Ireland.

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November 2018
4 Reads

Molecular function and biological importance of CNNM family Mg2+ transporters.

J Biochem 2018 Nov 22. Epub 2018 Nov 22.

Department of Cellular Regulation, Research Institute for Microbial Diseases, Osaka University.

Cyclin M (CNNM) family proteins are evolutionarily conserved Mg2+ transporters. They extrude Mg2+ from cells and maintain intracellular Mg2+ levels within the normal range. Moreover, they play an important role in Mg2+ (re)absorption in the intestine and kidney by mediating the directional transport of Mg2+ across epithelial tissue from the tubular lumen to the body inside. Read More

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November 2018
1 Read

Polymorphisms in Th17-related genes and the pathogenesis of autoimmune thyroid disease.

Autoimmunity 2018 Nov 24:1-10. Epub 2018 Nov 24.

a Department of Biomedical Informatics, Division of Health Sciences , Osaka University Graduate School of Medicine , Osaka , Japan.

The prognosis of autoimmune thyroid disease (AITD) including Graves' disease (GD) and Hashimoto's disease (HD) is difficult to predict. We previously suggested that Th17 cells may be associated with the pathogenesis of AITD. However, the association between gene polymorphisms in Th17-related genes and the prognosis of AITD was not clarified. Read More

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November 2018
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Successful rituximab treatment of granulomatosis with polyangiitis with cranial neuropathies.

Inflamm Regen 2018 19;38:20. Epub 2018 Nov 19.

Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, Japan.

Background: In granulomatosis with polyangiitis (GPA), peripheral nerve involvement is common but central nervous system (CNS) involvement is extremely rare and treatment strategy has not been established. We report a case of intravenous cyclophosphamide (IVCY)-resistant GPA with associated cranial neuropathies that was successfully treated with rituximab (RTX).

Case Presentation: A 37-year-old man with intractable sinusitis had several months of headache, hoarseness, and dysphagia; a month of right-sided deafness and nasal bleeding; and a week of dysarthria, steppage gait, and numbness in the right L5 distribution. Read More

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November 2018
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Clonazepam improves the symptoms of two siblings with novel variants in the SYNJ1 gene.

Parkinsonism Relat Disord 2018 Nov 19. Epub 2018 Nov 19.

Department of Neurology, Peking University People's Hospital, Beijing, China. Electronic address:

Background: Mutations in the SYNJ1 gene have been associated with early-onset of atypical Parkinson's disease or severe neurodegeneration with intractable seizures. Due to the rarity of the disease, there were limitations in the quality of available treatment options for SYNJ1-related diseases.

Methods: Two affected siblings from a non-consanguineous family were evaluated through a set of clinical and laboratory tests. Read More

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November 2018
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Audiological outcomes in sudden sensorineural hearing loss with presumed inner ear hemorrhage.

Am J Otolaryngol 2018 Sep 26. Epub 2018 Sep 26.

Department of Otorhinolaryngology, The First Affiliated Hospital, Sun Yat-sen University and Institute of Otorhinolaryngology, Sun Yat-sen University, Guangzhou 510080, PR China. Electronic address:

Objective: To explore the hearing outcomes and prognostic factors in patients with sudden sensorineural hearing loss resulting from inner ear hemorrhage.

Methods: 42 patients (22 male and 20 female) were recruited from January 2016 to December 2017. Intravenous methylprednisolone and/or intratympanic corticosteroid were used as salvage therapy. Read More

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September 2018