Blood Coagul Fibrinolysis 2021 Jun 7. Epub 2021 Jun 7.
Hematology Department, Faculty of Paramedicine, AJA University of Medical Sciences Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine (IBTO), Tehran Ali Ebne Abitaleb Hospital, School of Medicine, Zahedan University of Medical Sciences, Zahedan Hematology Department, Allied Medical School, Iran University of Medical Sciences, Tehran Department of Paramedical Sciences, Qazvin University of Medical Sciences, Qazvin Hematology Department, Allied Medical School, Tehran University of Medical Sciences, Tehran, Iran.
Congenital factor XIII (FXIII) deficiency is one of the rarest bleeding disorders, with an incidence of one per 2 million persons. Intracranial hemorrhage (ICH), a major cause of mortality in FXIII deficiency, is reported to be associated with vascular endothelial growth factor (VEGF) and thrombospondin-1 (TSP-1). Therefore, we investigated the association of VEGF and TSP-1 expression and methylation patterns with ICH in congenital FXIII deficiency patients. Read More