1,879 results match your criteria Intra-abdominal Sepsis


The Influence of Preoperative Medications on Postoperative Complications in Patients After Intestinal Surgery for Crohn's Disease.

Inflamm Bowel Dis 2019 Feb 8. Epub 2019 Feb 8.

Departments of Surgery, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.

Background: Many patients with Crohn's disease (CD) are treated with medications, including steroids, immunomodulators, and anti-tumor necrosis factor alpha (anti-TNF-α) agents, at the time of surgery. This study evaluated the effects of these medications on postoperative complications in CD patients.

Methods: This retrospective study analyzed patients who underwent bowel resection for CD between January 2006 and December 2015. Read More

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http://dx.doi.org/10.1093/ibd/izz010DOI Listing
February 2019
1 Read
4.464 Impact Factor

Intra- abdominal sepsis from a perforated duodenal ulcer-Management of a difficult surgical abdomen.

Int J Surg Case Rep 2019 Feb 1;55:171-173. Epub 2019 Feb 1.

Department of Surgery, College of Health Sciences, University of Nairobi, Kenya.

Introduction: Peptic ulcer perforation is a common surgical emergency that is a complication of 9% of patients with peptic ulcer disease (Kjetil et al., 2015 [1]). Despite advances in the management of peptic ulcer disease, the number of acute complications have remained constant. Read More

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http://dx.doi.org/10.1016/j.ijscr.2019.01.033DOI Listing
February 2019
1 Read

Hyponatremia could identify patients with intrabdominal sepsis and anastomotic leak after colorectal surgery: a systematic review of the literature.

Updates Surg 2019 Feb 8. Epub 2019 Feb 8.

Department of Colorectal Surgery, Chelsea and Westminster Hospital, 369 Fulham Rd, London, SW10 9NH, UK.

Anastomotic leak (AL) is a serious post-operative complication in colorectal surgery. It can lead to devastating morbidity and mortality. Clinicians usually depend on a combination of clinical, biochemical and radiological findings to diagnose this problem. Read More

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http://dx.doi.org/10.1007/s13304-019-00627-2DOI Listing
February 2019
1 Read

Pleural empyema in a patient with a perinephric abscess and diaphragmatic defect.

Respirol Case Rep 2019 Apr 29;7(3):e00400. Epub 2019 Jan 29.

Department of Respiratory Medicine Sir Charles Gairdner Hospital Nedlands Western Australia Australia.

Pleural infection as a complication of ascending urological infection is rare, and the mechanism often unclear. We report a complicated case of pleural infection and perinephric abscess in a patient who presented with a large right-sided pleural effusion. Pleural fluid culture yielded , an unusual pathogen in pleuro-pulmonary infections. Read More

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http://dx.doi.org/10.1002/rcr2.400DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350234PMC
April 2019
1 Read

Disseminated intestinal basidiobolomycosis with mycotic aneurysm mimicking obstructing colon cancer.

BMJ Case Rep 2019 Jan 29;12(1). Epub 2019 Jan 29.

Department of General Surgery, Ministry of Health, Dammam, Eastern Province, Saudi Arabia.

Basidiobolomycosis is a rare fungal infection that may affect the gastrointestinal tract. It is caused by and less than 80 cases have been reported in the literature. The incidence seems to be higher in the Middle East and in particular Saudi Arabia where most cases are diagnosed in the south-western region. Read More

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http://dx.doi.org/10.1136/bcr-2018-225054DOI Listing
January 2019
2 Reads

Intra-abdominal sepsis: new definitions and current clinical standards.

Langenbecks Arch Surg 2019 Jan 26. Epub 2019 Jan 26.

Medical Clinic II, University Hospital of Giessen, Giessen, Germany.

Purpose: The abdomen is the second most common source of sepsis and is associated with unacceptably high morbidity and mortality. Recently, the essential definitions of sepsis and septic shock were updated (Third International Consensus Definitions for Sepsis and Septic Shock, Sepsis-3) and modified. The purpose of this review is to provide an overview of the changes introduced by Sepsis-3 and the current state of the art regarding the treatment of abdominal sepsis. Read More

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http://dx.doi.org/10.1007/s00423-019-01752-7DOI Listing
January 2019
3 Reads

Endoluminal Vacuum Therapy: How I Do It.

J Gastrointest Surg 2019 Jan 22. Epub 2019 Jan 22.

Center for Advanced Surgery, Baylor Scott and White Health, 3417 Gaston Avenue, Suite 1000 East, Dallas, TX, 75246, USA.

Perforations and leaks of the gastrointestinal tract are difficult to manage and are associated with high morbidity and mortality. Recently, endoscopic approaches have been applied with varying degrees of success. Most recently, the use of endoluminal vacuum therapy has been used with high success rates in decreasing both morbidity and mortality. Read More

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http://dx.doi.org/10.1007/s11605-018-04082-zDOI Listing
January 2019
1 Read

Concise Commentary: The Clot Thickens-Why Pylephlebitis Is One of the Most Feared Complications of Intra-abdominal Sepsis.

Authors:
Jonathan G Stine

Dig Dis Sci 2019 Jan 2. Epub 2019 Jan 2.

Division of Gastroenterology and Hepatology, Department of Medicine, and Department of Public Health Sciences, The Pennsylvania State University Milton S. Hershey Medical Center, Hershey, PA, USA.

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http://dx.doi.org/10.1007/s10620-018-5440-6DOI Listing
January 2019
1 Read

Does retrieval bag use during laparoscopic appendectomy reduce postoperative infection?

Surgery 2018 Dec 24. Epub 2018 Dec 24.

Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; Center for Surgery and Public Health, Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA. Electronic address:

Background: Appendectomy is the most commonly performed emergency operation in the United States, with approximately 370,000 patients undergoing the procedure every year. Although laparoscopic appendectomy is associated with decreased complications when compared with open appendectomy, the risk for infectious complications, including surgical site infection, intra-abdominal abscess, and sepsis, remains a significant source of postoperative morbidity and health care cost. The goal of this study is to determine whether the appendix retrieval technique during laparoscopic appendectomy affects risk of infectious complications. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00396060183079
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http://dx.doi.org/10.1016/j.surg.2018.11.012DOI Listing
December 2018
4 Reads

[Research progress of the open abdomen in the treatment of gastrointestinal fistula with complicated intra-abdominal infection].

Zhonghua Wei Chang Wai Ke Za Zhi 2018 Dec;21(12):1446-1450

Department of Digestive Surgery, National Clinical Research Center for Digestive Diseases, Xijing Hospital of Digestive Diseases, The Airforce Medical University, Xi'an 710032, China, Email: edu.cn.

Gastrointestinal fistula patients may suffer from complicated intra-abdominal infection and sepsis with improper treatment, which is characterized by high mortality ranging from 20% to 60%, as well as high medical costs. Gastrointestinal fistula patients with complicated intra-abdominal infections are not often diagnosed early, and proper treatment remains an unsolved problem. Therefore it is a great challenge for surgeons to repair broken intestines under complicated intra-abdominal infection conditions and to repair ruptured intestines under conditions of severe abdominal adhesions and swelling of the intestinal wall and mesentery. Read More

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December 2018
1 Read

Extra-Anatomic Stents in Ureteric Obstruction: Our Experience.

J Endourol 2019 Feb 1. Epub 2019 Feb 1.

1 Department of Urology, Guy's and St Thomas' Hospitals, London, United Kingdom.

Objectives: To present our experience of the Detour extra-anatomic stent (EAS; Porges-Coloplast, Denmark) to bypass ureteric obstruction. Use of the EAS is indicated in patients with complex ureteric strictures or malignant disease, where long-term nephrostomy drainage is undesirable.

Materials And Methods: Between December 2001 and October 2017, 20 Detour EAS were implanted into 13 patients. Read More

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https://www.liebertpub.com/doi/10.1089/end.2018.0610
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http://dx.doi.org/10.1089/end.2018.0610DOI Listing
February 2019
3 Reads

Is intra-abdominal hypertension a risk factor for ventilator-associated pneumonia?

Ann Transl Med 2018 Nov;6(21):419

Department of Critical Care Medicine, University Hospital of Larisa, University of Thessaly School of Medicine, Larisa, Greece.

In the last years, there has been a significant amount of research about the impact of intra-abdominal hypertension (IAH) on the outcomes of critical care patients. IAH is increasingly recognized as potential complication in intensive care unit (ICU) patients. IAH affects all body systems, most notably the cardiac, respiratory, renal, and neurologic systems. Read More

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http://dx.doi.org/10.21037/atm.2018.08.27DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6275402PMC
November 2018
1 Read

Abdominal Sepsis: An Update.

J Crit Care Med (Targu Mures) 2018 Oct 1;4(4):120-125. Epub 2018 Oct 1.

University of Medicine, Pharmacy, Sciences and Technology of Târgu Mureş, Târgu Mureş Romania.

Despite the significant development and advancement in antibiotic therapy, life-threatening complication of infective diseases cause hundreds of thousands of deaths world. This paper updates some of the issues regarding the etiology and treatment of abdominal sepsis and summaries the latest guidelines as recommended by the Intra-abdominal Infection (IAI) Consensus (2017). Prognostic scores are currently used to assess the course of peritonitis. Read More

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http://content.sciendo.com/view/journals/jccm/4/4/article-p1
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http://dx.doi.org/10.2478/jccm-2018-0023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6296273PMC
October 2018
8 Reads

Systematic Review of Laparostomy/Open Abdomen to Prevent Acute Compartimental Syndrome (ACS).

Maedica (Buchar) 2018 Sep;13(3):179-182

Carlo Urbani Hospital, Jesi, Ancona, Italy.

Laparostomy is defined as a surgical technique in which the peritoneal cavity is opened and left open, called "open abdomen" (OA). An open abdomen presents numerous challenges for the clinician. Specific pathologies like severe intraabdominal sepsis, trauma requiring damage control, abdominal compartment syndrome, staged abdominal repair and other complex abdominal pathologies can be managed with laparostomy. Read More

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http://dx.doi.org/10.26574/maedica.2018.13.3.179DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290176PMC
September 2018
1 Read

"Management of Duodenal Trauma: A Retrospective Review From The Pan-American Trauma Society'.

J Trauma Acute Care Surg 2018 Dec 6. Epub 2018 Dec 6.

Shock Trauma Centre, University of Maryland.

Introduction: The operative management of duodenal trauma remains controversial. Our hypothesis is that a simplified operative approach could lead to better outcomes.

Methods: We conducted an international multicenter study, involving thirteen centers. Read More

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http://dx.doi.org/10.1097/TA.0000000000002157DOI Listing
December 2018
1 Read

[Intra-abdominal infections. Update and recommendations].

Medicina (B Aires) 2018 ;78(6):417-426

Hospital Prof. Alejandro Posadas, El Palomar, Buenos Aires, Argentina.

Intra-abdominal infections represent a group of intra and retroperitoneal processes, ranging from localized infections to complicated ones, sepsis and septic shock, associated with a significant mortality rate. They are the third most commonly identified cause of sepsis and the second cause of death in the intensive care unit. Although antimicrobial therapy must be started as soon as possible, especially in critically ill patients, the source control procedure is highly relevant. Read More

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January 2018
1 Read

Comparative genomics of transport proteins in seven Bacteroides species.

PLoS One 2018 5;13(12):e0208151. Epub 2018 Dec 5.

Department of Molecular Biology, Division of Biological Sciences, University of California at San Diego, La Jolla, CA, United States of America.

The communities of beneficial bacteria that live in our intestines, the gut microbiome, are important for the development and function of the immune system. Bacteroides species make up a significant fraction of the human gut microbiome, and can be probiotic and pathogenic, depending upon various genetic and environmental factors. These can cause disease conditions such as intra-abdominal sepsis, appendicitis, bacteremia, endocarditis, pericarditis, skin infections, brain abscesses and meningitis. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0208151PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6281302PMC
December 2018
3 Reads

Methods of Conservative Antibiotic Treatment of Acute Uncomplicated Appendicitis: A Systematic Review.

J Trauma Acute Care Surg 2018 Dec 3. Epub 2018 Dec 3.

Professor of Medicine and Emergency Medicine, Department of Emergency Medicine (and Department of Medicine, Division of Infectious Diseases), Olive View-UCLA Medical Center, 14445 Olive View Drive, North Annex, Sylmar, CA 91342.

Background: Meta-analyses and a recent guideline acknowledge that conservative management of uncomplicated appendicitis with antibiotics can be successful for patients who wish to avoid surgery. However, guidance as to specific management does not exist.

Methods: PUBMED and EMBASE search of trials describing methods of conservative treatment was conducted according to PRISMA guidelines. Read More

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http://dx.doi.org/10.1097/TA.0000000000002137DOI Listing
December 2018
2 Reads

Early Laparoscopic Washout may Resolve Persistent Intra-abdominal Infection Post-appendicectomy.

World J Surg 2018 Nov 26. Epub 2018 Nov 26.

Department of Surgery, Nepean Hosptial, P. O. Box 67, Penrith, NSW, 2751, Australia.

Background: Intra-abdominal abscess (IAA) complicates 2-3% of patients having an appendicectomy. The usual management is prolonged antibiotics and drainage of the IAA. From 2006, our unit chose to use early re-laparoscopy and washout in patients with persistent sepsis following appendicectomy. Read More

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http://link.springer.com/10.1007/s00268-018-4871-8
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http://dx.doi.org/10.1007/s00268-018-4871-8DOI Listing
November 2018
11 Reads

Laparoscopic Repair for Perforated Peptic Ulcer Disease Has Better Outcomes Than Open Repair.

J Gastrointest Surg 2018 Nov 21. Epub 2018 Nov 21.

The Whiteley-Martin Research Centre, Discipline of Surgery, Nepean Hospital, The University of Sydney, Level 5, South Block, P.O. Box 63, Penrith, NSW, 2751, Australia.

Purpose: Over the last 3 decades, laparoscopic procedures have emerged as the standard treatment for many elective and emergency surgical conditions. Despite the increased use of laparoscopic surgery, the role of laparoscopic repair for perforated peptic ulcer remains controversial among general surgeons. The aim of this study was to compare the outcomes of laparoscopic versus open repair for perforated peptic ulcer. Read More

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http://dx.doi.org/10.1007/s11605-018-4047-8DOI Listing
November 2018
16 Reads

Outcomes of early relaparotomy in pediatric patients at Tikur Anbessa teaching hospital, Addis Ababa, Ethiopia: a five-year retrospective review.

BMC Surg 2018 Nov 16;18(1):99. Epub 2018 Nov 16.

Addis Ababa University, Addis Ababa, Ethiopia.

Background: Early relaparotomy is defined as relaparotomy within the first 30 days following surgery. The aim of this study is to explore the indications, outcomes and factors associated with relaparotomy in our pediatric population.

Methods: We performed a retrospective study of pediatric surgical patients (< 13 yrs. Read More

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http://dx.doi.org/10.1186/s12893-018-0436-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240246PMC
November 2018
2 Reads

[Clinical characteristics and predictors of mortality in patients with candidemia in intensive care unit].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2018 Oct;30(10):929-932

Department of Critical Care Medicine, Peking University People's Hospital, Beijing 100044, China (Zhao HY, Wu PH, Wang GJ, Wang HX, Zhu FX, An YZ); Department of Clinical Laboratory, Peking University People's Hospital, Beijing 100044, China (Wang Q). Corresponding author: An Youzhong, Email:

Objective: To investigate the clinical characteristics and predictors of mortality in patients with candidemia in intensive care unit (ICU).

Methods: The patients with candidemia admitted to ICU of Peking University People's Hospital from January 2010 to December 2017 were enrolled. The general clinical data, indicators related to Candidia infection and prognosis were collected, and the clinical characteristics, infection characteristics and prognosis of patients with candidiasis were analyzed. Read More

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http://dx.doi.org/10.3760/cma.j.issn.2095-4352.2018.010.004DOI Listing
October 2018
11 Reads

Robotic distal pancreatectomy with selective closure of pancreatic duct: surgical outcomes.

Updates Surg 2018 Nov 14. Epub 2018 Nov 14.

Division of Oncological and Robotic General Surgery, Careggi University Hospital, Florence, Italy.

Pancreatic fistula is the main post-operative complication of distal pancreatectomy associated with other further complications, such as intra-abdominal abscesses, wound infection, sepsis, electrolyte imbalance, malabsorption and hemorrhage. Surgeons have tried various techniques to close the stump of the remaining pancreas, but the controversy regarding the impact of stapler closure and suture closure of the pancreatic stump is far from resolved. In this study, we reported our technique and results of robotic assisted distal pancreatectomy with ultrasound identification and consequent selective closure of pancreatic duct. Read More

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http://link.springer.com/10.1007/s13304-018-0605-6
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http://dx.doi.org/10.1007/s13304-018-0605-6DOI Listing
November 2018
12 Reads

Mortality and morbidity after pancreatoduodenectomy in patients undergoing hemodialysis: Analysis using a national inpatient database.

Surgery 2018 Nov 10. Epub 2018 Nov 10.

National Center for Global Health and Medicine, Tokyo, Japan.

Background: Whether patients undergoing hemodialysis have greater risks of mortality and morbidity after pancreatoduodenectomy remains unknown.

Methods: We used the Diagnosis Procedure Combination database, a national Japanese inpatient database, to identify patients who underwent pancreatoduodenectomy from July 2010 to March 2015. We conducted propensity-score-matching analyses to compare the outcomes, including postoperative complications and 30- and 90-day mortality after pancreatoduodenectomy between patients with and without hemodialysis. Read More

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http://dx.doi.org/10.1016/j.surg.2018.10.009DOI Listing
November 2018
7 Reads

A Double Whammy: Lactobacillus acidophilus Bacteremia and Subsequent Lactobacillus rhamnosus Prosthetic Valve Infective Endocarditis in an Elderly Diabetic Patient.

R I Med J (2013) 2018 Nov 1;101(9):32-35. Epub 2018 Nov 1.

Assistant Professor of Medicine, The Warren Alpert Medical School of Brown University, Department of Infectious Diseases, Providence VA Medical Center.

The clinical significance of the relatively avirulent organ- ism, Lactobacillus, has been debated in the past. At times misdiagnosed as a contaminant, Lactobacillus has uncommonly been reported to cause intra-abdominal abscesses, peritonitis, meningitis, bacteremia, pneumonia and endocarditis, especially in the population of patients with underlying comorbid conditions including malignancy, diabetes, recent surgery or organ transplantation. We report a case of a 74-year-old male with Lactobacillus bacteremia leading to prosthetic valve infective endocarditis complicated by an aortic root abscess. Read More

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November 2018
2 Reads

[Blunt abdominal trauma causing acute pancreatitis: presentation of the case study].

Pan Afr Med J 2018 13;30:126. Epub 2018 Jun 13.

Service des Urgences Hôpital Régional de Kasserin, Tunisie.

Acute pancreatitis is a serious disease having a guarded prognosis. Its etiology involves either bladder or alcohol. Traumatic origin is extremely rare and it is often associated with other intra-abdominal lesions. Read More

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http://www.panafrican-med-journal.com/content/article/30/126
Publisher Site
http://dx.doi.org/10.11604/pamj.2018.30.126.14675DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201622PMC
November 2018
10 Reads

Contrast radiography before diverting stoma closure in rectal cancer is not necessary on a routine basis.

Cir Esp 2018 Oct 19. Epub 2018 Oct 19.

Sección de Cirugía Colorrectal, Departamento de Cirugía, Hospital del Mar, Barcelona, España; Grupo de Investigación en Cáncer Colorrectal, Instituto de Investigación Médica Hospital del Mar (IMIM), Barcelona, España.

Introduction: Diverting stomata are recommended in patients with low anterior resection and risk factors in order to reduce the severity of anastomotic leaks. Usually, a radiology study is performed prior to the closure of the stoma to detect subclinical leaks. The aim of the present study is to assess the clinical utility of the radiology study. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0009739X183022
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http://dx.doi.org/10.1016/j.ciresp.2018.08.005DOI Listing
October 2018
9 Reads

Outcome of patients with acute pancreatitis requiring intensive care admission: A retrospective study from a tertiary care center of Pakistan.

Pak J Med Sci 2018 Sep-Oct;34(5):1082-1087

Muhammad Sohaib, Department of Anaesthesiology, The Aga Khan University, Karachi, Pakistan.

Background And Objective: Acute pancreatitis (AP) is an inflammatory disease. Patients presenting with severe disease may require intensive care unit (ICU) admission. Factors predicting mortality and morbidity need to be identified for improving outcome. Read More

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http://pjms.com.pk/index.php/pjms/article/view/15575
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http://dx.doi.org/10.12669/pjms.345.15575DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6191773PMC
October 2018
13 Reads

Hidden diagnosis behind viral infection: the danger of anchoring bias.

BMJ Case Rep 2018 Oct 21;2018. Epub 2018 Oct 21.

Department of General Pediatrics and Interdisciplinary Medicine, National Center for Child Health and Development, Tokyo, Japan.

Anchoring bias is one of the most common diagnostic biases that may lead to closed-minded thinking and could result in unnecessary tests, inappropriate patient management and even misdiagnosis. A 4-year-old boy was brought to the emergency department because of shaking chills. On the basis of bilateral swollen preauricular areas, high level of serum amylase and the prevalence of mumps, he initially received a diagnosis of mumps in spite of the shaking chills. Read More

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http://dx.doi.org/10.1136/bcr-2018-226613DOI Listing
October 2018
5 Reads

Abdominal organ perfusion and inflammation in experimental sepsis: a magnetic resonance imaging study.

Am J Physiol Gastrointest Liver Physiol 2019 Jan 18;316(1):G187-G196. Epub 2018 Oct 18.

Hedenstierna Laboratoriet, Department of Surgical Science, Uppsala University , Uppsala , Sweden.

Diffusion-weighted magnetic resonance imaging (DW-MRI) uses water as contrast and enables the study of perfusion in many organs simultaneously in situ. We used DW-MRI in a hypodynamic sepsis model, comparing abdominal organ perfusion with global hemodynamic measurements and inflammation. Sixteen anesthetized piglets were randomized into 3 groups: 2 intervention (sepsis) groups: HighMAP (mean arterial pressure, MAP > 65 mmHg) and LowMAP (MAP between 50 and 60 mmHg), and a Healthy Control group (HC). Read More

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http://dx.doi.org/10.1152/ajpgi.00151.2018DOI Listing
January 2019
4 Reads

Complicated intra-abdominal infections: a prospective validation study of the WSES Sepsis Severity Score.

Singapore Med J 2018 Oct 10. Epub 2018 Oct 10.

Department of Surgery, College of Medicine and Health Sciences, UAE University, Al-Ain, United Arab Emirates.

Introduction: The World Society of Emergency Surgery (WSES) has recently developed and validated a sepsis severity score for complicated intra-abdominal infections (cIAIs). We aimed to prospectively study the validity of this score in our local setting and compare it with global findings.

Methods: In a prospective study of 100 consecutive adult patients with cIAIs treated at Al-Ain Hospital, United Arab Emirates, from October 2014 to January 2016, we studied the demography of patients, disease, risk factors, WSES Sepsis Severity Score, management, hospital stay and mortality. Read More

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http://www.smj.org.sg/sites/default/files/OA-2017-111-epub.p
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http://dx.doi.org/10.11622/smedj.2018120DOI Listing
October 2018
6 Reads

Intra-abdominal Sepsis After Ileocolic Resection in Crohn's Disease: The Role of Combination Immunosuppression.

Dis Colon Rectum 2018 12;61(12):1393-1402

Division of Colon and Rectal Surgery, Mayo Clinic, Rochester, Minnesota.

Background: Intra-abdominal sepsis complicates <10% of ileocolic resections for Crohn's disease, but the impact of combination immunosuppression and repeat resection on its development remains unknown.

Objective: The purpose of this study was to determine risk factors for intra-abdominal sepsis after ileocolic resection, specifically examining the role of combination immunosuppression and repeat intestinal resection.

Design: This was a retrospective review of patient records from 2007 to 2017. Read More

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http://dx.doi.org/10.1097/DCR.0000000000001153DOI Listing
December 2018
7 Reads

Microbe Isolation from Blood, Central Venous Catheters, and Fluid Collections after Liver Resections.

Surg Infect (Larchmt) 2019 Jan 9;20(1):49-54. Epub 2018 Oct 9.

Second Department of Propaedeutic Surgery, "Laiko" General Hospital, National and Kapodistrian University of Athens , Medical School, Athens, Greece .

Background: Our goal was to evaluate the microbe species responsible for bacteremia or infections related to central venous catheter (CVC) or fluid collections after liver resection.

Patients And Methods: Data from 112 patients (68 males, 44 females) who underwent liver resection over a period of 63 months were reviewed. Patient and tumor characteristics, intra-operative and post-operative data, and the results from cultures of peripheral blood, CVC tips and drained intra-abdominal or intra-throracic fluid collections were collected. Read More

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http://dx.doi.org/10.1089/sur.2018.122DOI Listing
January 2019
2 Reads

The Impact of Prior Laparotomy and Intra-abdominal Adhesions on Bowel and Mesenteric Injury Following Blunt Abdominal Trauma.

World J Surg 2019 Feb;43(2):457-465

Department of Surgery, University of Florida Health, 1600 SW Archer Road, Box 100108, Gainesville, FL, 32610, USA.

Background: Early recognition of bowel and mesenteric injury following blunt abdominal trauma remains difficult. We hypothesized that patients with intra-abdominal adhesions from prior laparotomy would be subjected to visceral sheering deceleration forces and increased risk for bowel and mesenteric injury following blunt abdominal trauma.

Methods: We performed a multicenter retrospective cohort analysis of 267 consecutive adult trauma patients who underwent operative exploration following moderate-critical (abdominal injury score 2-5) blunt abdominal trauma, comparing patients with prior laparotomy (n = 31) to patients with no prior laparotomy (n = 236). Read More

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http://dx.doi.org/10.1007/s00268-018-4792-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330127PMC
February 2019
5 Reads

The IL-33-ST2 Pathway Contributes to Ventilator-Induced Lung Injury in Septic Mice in a Tidal Volume-Dependent Manner.

Shock 2018 Sep 5. Epub 2018 Sep 5.

Department of Anesthesiology, East Hospital, Tongji University School of Medicine, Shanghai, China.

Mechanical ventilation (MV) is frequently employed to manage respiratory failure in sepsis patients and is required for the surgical management of intra-abdominal sepsis. The impact of MV varies dramatically depending on tidal volume, with even moderate tidal volume (MTV) ventilation leading to ventilator-induced lung injury, whereas low tidal volume (LTV) ventilation protects against sepsis-induced ARDS. IL-33 is known to contribute to lung injury in sepsis and its release can be induced by mechanical stress. Read More

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http://dx.doi.org/10.1097/SHK.0000000000001260DOI Listing
September 2018
3 Reads
1 Citation
3.045 Impact Factor

[Clinical analysis of small incision minimally invasive approach in treatment of infected pancreatic necrosis].

Zhonghua Wai Ke Za Zhi 2018 Sep;56(9):687-692

Department of Pancreatic and Biliary Surgery, the First Affiliated Hospital of Harbin Medical University, Harbin 150001, China.

To investigate the safety and efficiency of small incision minimally invasive approach pancreatic necrosectomy in the treatment of infected pancreatic necrosis. The data of 164 patients who underwent small incision minimally invasive approach pancreatic necrosectomy for infected pancreatic necrosis at Department of Pancreatic and Biliary Surgery, the First Affiliated Hospital of Harbin Medical University from January 2012 to December 2016 were analyzed retrospectively.Among 164 patients, there were 102 male and 62 female patients. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0529-5815.2018.09.009DOI Listing
September 2018
14 Reads

Optimal infusion rate in antimicrobial therapy explosion of evidence in the last five years.

Infect Drug Resist 2018 8;11:1105-1117. Epub 2018 Aug 8.

Department of Pharmacy, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, People's Republic of China,

Background: Sporadic studies in antimicrobial therapy have evaluated the effects of infusion rates on therapeutic and economic outcomes, and new findings may challenge the regular infusion regimen.

Methods: Focusing on studies comparing the outcomes of different infusion regimens, the relevant literature was identified by searching PubMed, Web of Science, and Scopus from January 1, 2013 to March 1, 2018. Papers were finally chosen using a PRISMA flowchart. Read More

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http://dx.doi.org/10.2147/IDR.S167616DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6089111PMC
August 2018
2 Reads

Massive Pneumoperitoneum Presenting as an Incidental Finding.

Cureus 2018 Jun 11;10(6):e2787. Epub 2018 Jun 11.

Medical Oncology, Thomas Jefferson University Hospital, Philadelphia, USA.

Pneumoperitoneum is often associated with surgical complications or intra-abdominal sepsis. While commonly deemed a surgical emergency, pneumoperitoneum in a minority of cases does not involve a viscus perforation or require urgent surgical management; these cases of "spontaneous pneumoperitoneum" can stem from a variety of etiologies. We report a case of a 72-year-old African American male with a history of metastatic pancreatic adenocarcinoma who presented with new-onset abdominal distention and an incidentally discovered massive pneumoperitoneum with no clear source of perforation on surveillance imaging. Read More

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http://dx.doi.org/10.7759/cureus.2787DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6089479PMC
June 2018
3 Reads

Effectiveness of ceftazidime/avibactam as salvage therapy for treatment of infections due to OXA-48 carbapenemase-producing Enterobacteriaceae.

J Antimicrob Chemother 2018 Nov;73(11):3170-3175

Infectious Diseases Unit-Internal Medicine Department, Hospital Álvaro Cunqueiro, Complejo Hospitalario Universitario de Vigo, Vigo, Spain.

Background: Experience in real clinical practice with ceftazidime/avibactam is limited, and there are even fewer data on infections due to OXA-48-producing Enterobacteriaceae.

Methods: We designed an observational study of a prospectively collected cohort of adult patients receiving ceftazidime/avibactam in our centre. Only the first treatment course of each patient was analysed. Read More

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http://dx.doi.org/10.1093/jac/dky295DOI Listing
November 2018
18 Reads

Multicenter performance evaluation of the Unyvero IAI cartridge for detection of intra-abdominal infections.

Eur J Clin Microbiol Infect Dis 2018 Nov 10;37(11):2107-2115. Epub 2018 Aug 10.

Laboratoire de Bactériologie-Hygiène Hospitalière, Institut Fédératif de Biologie, Hôpital Purpan, CHU de Toulouse, Toulouse, France.

Intra-abdominal infections (IAIs) are one of the most common type of infections in patients with sepsis and an important cause of death in intensive care units. Early detection and treatment are necessary to reduce patient complications and improve outcomes. The Unyvero IAI Application (Curetis GmbH) is the first automated assay to rapidly and simultaneously identify a large panel of bacteria, fungi, toxins, and antibiotic resistance markers directly from IAI-related samples. Read More

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http://dx.doi.org/10.1007/s10096-018-3345-0DOI Listing
November 2018

Evidence and Perspectives on the Use of Polymyxin B-Immobilized Fiber Column Hemoperfusion among Critically Ill Patients.

Contrib Nephrol 2018 24;196:215-222. Epub 2018 Jul 24.

Background: Sepsis frequently leads to multiple organ failure due to the uncontrolled amplification and spread of inflammation, even if the infectious source is controlled. Lipopolysaccharide (LPS), a typical pathogen-associated molecular pattern (PAMP), is adsorbed by the polymyxin B-immobilized fiber column (PMX). PMX has been used for decades in Europe. Read More

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http://dx.doi.org/10.1159/000485725DOI Listing
July 2018
13 Reads

A pharmacokinetic case study of intravenous posaconazole in a critically ill patient with hypoalbuminaemia receiving continuous venovenous haemodiafiltration.

Int J Antimicrob Agents 2018 Oct 19;52(4):506-509. Epub 2018 Jul 19.

School of Pharmacy, Centre for Translational Anti-infective Pharmacodynamics, The University of Queensland, Brisbane, Australia; Department of Intensive Care Medicine, Royal Brisbane and Women's Hospital, Brisbane, Australia; University of Queensland Centre for Clinical Research, Faculty of Medicine, The University of Queensland, Brisbane, Australia; Pharmacy Department, Royal Brisbane and Women's Hospital, Brisbane, Australia. Electronic address:

This article reports a pharmacokinetic case study of intravenous posaconazole in a 49-year-old male patient with intra-abdominal sepsis and hypoalbuminaemia receiving continuous venovenous haemodiafiltration. Concentration-time data following 300 mg intravenous posaconazole was analysed using a population pharmacokinetics approach. The 300-mg intravenous dose appears to be adequate for the treatment of yeast infections; however, for the treatment of invasive aspergillosis in isolated cases of critically ill patients with hypoalbuminaemia, the current dosing may not achieve desired exposure, although steady state exposure data are needed. Read More

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http://dx.doi.org/10.1016/j.ijantimicag.2018.07.008DOI Listing
October 2018
5 Reads

Effects of temporary abdominal closure methods on mortality and morbidity in patients with open abdomen.

Ulus Travma Acil Cerrahi Derg 2018 Jul;24(4):321-326

Department of General Surgery, Mustafa Kemal University Faculty of Medicine, Hatay-Turkey.

Background: Open abdomen (OA) in which the abdomen is closed with temporary abdominal closure methods is the most effective in patients who develop severe abdominal sepsis or abdominal compartment syndrome. Major techniques used are Vacuum-Assisted Closure Method (VACM) and non-vacuum assisted closure method (NVACM). In the present study, the effects of different abdominal closure methods on morbidity and mortality were evaluated. Read More

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http://dx.doi.org/10.5505/tjtes.2017.95038DOI Listing
July 2018
3 Reads

Microdialysis Study of Aztreonam-Avibactam Distribution in Peritoneal Fluid and Muscle of Rats with or without Experimental Peritonitis.

Antimicrob Agents Chemother 2018 Oct 24;62(10). Epub 2018 Sep 24.

INSERM, U1070, UFR de Médecine Pharmacie, Université de Poitiers, TSA 51106, Poitiers, France

The purpose of this study was to investigate aztreonam (ATM) and avibactam (AVI) distribution in intraperitoneal fluid and muscle interstitial fluid by microdialysis in rats, with or without peritonitis, and to compare the unbound concentrations in tissue with the unbound concentrations in blood. Microdialysis probes were inserted into the jugular veins, hind leg muscles, and peritoneal cavities of control rats ( = 5) and rats with intra-abdominal sepsis ( = 9) induced by cecal ligation and punctures. ATM and AVI probe recoveries in each medium were determined for both molecules in each rat by retrodialysis by drug. Read More

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http://aac.asm.org/lookup/doi/10.1128/AAC.01228-18
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http://dx.doi.org/10.1128/AAC.01228-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6153784PMC
October 2018
31 Reads

Incidence, causes and risk factors for 30-day readmission after radical gastrectomy for gastric cancer: a retrospective study of 2,023 patients.

Sci Rep 2018 Jul 12;8(1):10582. Epub 2018 Jul 12.

Department of Gastroduodenal and Pancreatic Surgery, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, 410013, Changsha, China.

The aim of this retrospective study was to investigate the incidence of, causes and risk factors for readmission to hospital ≤30 days after discharge of patients who underwent radical gastrectomy for gastric cancer. A total of 2,023 patients underwent radical gastrectomy operations from November 2010 to July 2017 in our hospital. Of these, 60 patients (3. Read More

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http://dx.doi.org/10.1038/s41598-018-28850-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6043555PMC
July 2018
8 Reads
5.080 Impact Factor

Closed Or Open after Source Control Laparotomy for Severe Complicated Intra-Abdominal Sepsis (the COOL trial): study protocol for a randomized controlled trial.

World J Emerg Surg 2018 22;13:26. Epub 2018 Jun 22.

Department of Surgery, Macerata Hospital, Macerata, Italy.

Background: Severe complicated intra-abdominal sepsis (SCIAS) has an increasing incidence with mortality rates over 80% in some settings. Mortality typically results from disruption of the gastrointestinal tract, progressive and self-perpetuating bio-mediator generation, systemic inflammation, and multiple organ failure. Principles of treatment include early antibiotic administration and operative source control. Read More

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http://dx.doi.org/10.1186/s13017-018-0183-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6015449PMC
December 2018
38 Reads
1.062 Impact Factor

Derivation of a PIRO Score for Prediction of Mortality in Surgical Patients With Intra-Abdominal Sepsis.

Am J Crit Care 2018 Jul;27(4):287-294

All authors are at the University of Calgary, Calgary, Alberta, Canada. Juan G. Posadas-Calleja is a clinical assistant professor, Department of Critical Care Medicine. Henry T. Stelfox is a professor, Departments of Critical Care Medicine, Community Health Sciences, and Medicine. Andre Ferland is a clinical associate professor, Departments of Critical Care Medicine and Medicine. Danny J. Zuege is a clinical professor, Department of Critical Care Medicine and Division of Respiratory Medicine. Daniel J. Niven is an assistant professor, Departments of Critical Care Medicine and Community Health Sciences. Luc Berthiaume is a clinical associate professor, Departments of Critical Care Medicine and Community Health Sciences and Division of Respiratory Medicine. Christopher James Doig is a professor and head, Department of Critical Care Medicine, and a professor, Departments of Community Health Sciences and Medicine.

Background: Mortality in patients with intra-abdominal sepsis remains high. Recognition and classification of patients with sepsis are challenging; about 70% of critical care specialists find the existing definitions confusing and not clinically useful.

Objective: To assess the usefulness of the predisposition, infection/injury, response, organ dysfunction (PIRO) concept in surgical intensive care patients with severe sepsis or septic shock due to an intra-abdominal source. Read More

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http://dx.doi.org/10.4037/ajcc2018576DOI Listing
July 2018
2 Reads

Effect of hypobaria and hyperoxia during sepsis on survival and energy metabolism.

J Trauma Acute Care Surg 2018 Jul;85(1S Suppl 2):S68-S76

From the Center for Vaccine Development, (M.C., K.A., A.S.C.) University of Maryland School of Medicine, Baltimore, Maryland, Department of Anesthesiology, and Shock, Trauma, and Anesthesiology Research Center (STAR) (P.T., J.L.P., A.M., P.F.S., G.F.), and Department of Pathology (T.C.), University of Maryland School of Medicine, Baltimore, Maryland.

Background: Injured warfighters air evacuated to tertiary medical care facilities are subjected to many stresses that may promote the development of sepsis. In this study, we tested the hypothesis that exposure to "in-flight" hypobaria and/or hyperoxia within 24 hours after onset of intra-abdominal infection in rats accelerates the development and/or severity of sepsis and neurologic injury in survivors.

Methods: Sprague-Dawley rats underwent cecal ligation/puncture (CLP) or sham procedures. Read More

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http://dx.doi.org/10.1097/TA.0000000000001909DOI Listing
July 2018
18 Reads