2,126 results match your criteria Intra-abdominal Sepsis


Plasma Microbial Cell-Free DNA Sequencing Technology for the Diagnosis of Sepsis in the ICU.

Front Mol Biosci 2021 28;8:659390. Epub 2021 May 28.

Department of Laboratory Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.

Sepsis is a common life-threatening disease in the intensive care unit (ICU) that is usually treated empirically without pathogen identification. As a non-invasive and high-throughput technology, plasma microbial cell-free DNA (mcfDNA) sequencing can detect unknown pathogens independent of previous clinical or laboratory information. In this study, a total of 199 cases suspected of bloodstream infection (BSI) from January 2020 to June 2020 were collected, and potential pathogens were detected by simultaneous blood culture and plasma mcfDNA sequencing. Read More

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AMPK activates Parkin independent autophagy and improves post sepsis immune defense against secondary bacterial lung infections.

Sci Rep 2021 Jun 11;11(1):12387. Epub 2021 Jun 11.

Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, 35294-0012, USA.

Metabolic and bioenergetic plasticity of immune cells is essential for optimal responses to bacterial infections. AMPK and Parkin ubiquitin ligase are known to regulate mitochondrial quality control mitophagy that prevents unwanted inflammatory responses. However, it is not known if this evolutionarily conserved mechanism has been coopted by the host immune defense to eradicate bacterial pathogens and influence post-sepsis immunosuppression. Read More

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Clinical characteristics of patients with open abdomen at ICU. A retrospective analysis

Rev Med Inst Mex Seguro Soc 2020 04 13;58(2):108-113. Epub 2020 Apr 13.

Instituto Mexicano del Seguro Social, Centro Médico Nacional La Raza, Hospital de Especialidades "Dr. Antonio Fraga Mouret", Unidad de Cuidados Intensivos. Ciudad de México, México.

Background: The open abdomen is a surgical management strategy in patients with increased intra-abdominal pressure or when the abdominal wall cannot be closed.

Objective: The aim of this study is to describe the characteristics and clinical outcome of a group of surgical patients with open abdomen who have been admitted to an ICU.

Material And Mehotds: Retrospective study in an ICU of a public hospital of reference with subjects admitted with open abdomen. Read More

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Elevated Right Hemidiaphragm: A Clue in Acute Cholecystitis?

Cureus 2021 Apr 20;13(4):e14571. Epub 2021 Apr 20.

Department of Hepato-Pancreato-Biliary and Transplant Surgery, Singapore General Hospital, Singapore, SGP.

Two patients presented to the Emergency Department with sepsis and vague localising complaints. Both of them had a new elevation of the right hemidiaphragm on chest radiography and were eventually diagnosed with complicated acute cholecystitis on CT imaging. In both cases, the hemidiaphragmatic elevation could not be explained by mass effect as there was no sizable intra-abdominal collection. Read More

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Lactobacillus gasseri liver abscess and bacteremia: a case report.

BMC Infect Dis 2021 Jun 2;21(1):518. Epub 2021 Jun 2.

Department of Internal Medicine, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Vasco de Quiroga 15, Tlalpan, 14080, Mexico City, Mexico.

Background: Lactobacillus is a genus of Gram-positive non-spore-forming rods usually found in the microbiota of the oral cavity, gastrointestinal tract, and female genitourinary tract. Also, they are commonly used in the food industry as supplements and probiotics. Lactobacilli are normally considered non-pathogenic to the human body, however, under certain circumstances such as immunosuppression, they can cause severe infections, with only a few cases of bacteremia, infective endocarditis, pneumonia, meningitis, and intra-abdominal infections reported. Read More

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Primary pneumococcal peritonitis with a fulminant course.

Vnitr Lek 2021 ;67(E-2):34-37

Introduction: Primary peritonitis is an inflammation of the peritoneal cavity in the absence of a localized intra-abdominal source. It is included in the differential diagnosis of acute abdomen and can be potentially life-threatening. Pneumococci were a frequent pathogen causing primary peritonitis especially in the preantibiotic era. Read More

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Intra-Abdominal Lipopolysaccharide Clearance and Inactivation in Peritonitis: Key Roles for Lipoproteins and the Phospholipid Transfer Protein.

Front Immunol 2021 12;12:622935. Epub 2021 May 12.

Université Bourgogne Franche-Comté / Agrosup, Lipids Nutrition Cancer (LNC) UMR1231, Dijon, France.

Introduction: During peritonitis, lipopolysaccharides (LPS) cross the peritoneum and pass through the liver before reaching the central compartment. The aim of the present study was to investigate the role of lipoproteins and phospholipid transfer protein (PLTP) in the early stages of LPS detoxification.

Material And Methods: Peritonitis was induced by intra-peritoneal injection of LPS in mice. Read More

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Cecal Slurry Injection in Neonatal and Adult Mice.

Methods Mol Biol 2021 ;2321:27-41

Department of Surgery, University of Florida College of Medicine, Gainesville, FL, USA.

Studying the pathophysiology of sepsis still requires animal models, and the mouse remains the most commonly used species. Here we discuss the "cecal slurry" (CS) model of polymicrobial, peritoneal sepsis and compare and contrast it to other commonly used methods. Among the different murine models of sepsis, cecal ligation and puncture (CLP), and not the CS, is often considered the "gold standard" to induce polymicrobial sepsis in laboratory animals. Read More

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January 2021

Antimicrobial Lessons From a Large Observational Cohort on Intra-abdominal Infections in Intensive Care Units.

Drugs 2021 Jun 26;81(9):1065-1078. Epub 2021 May 26.

UFR Denis Diderot, INSERM UMR 1152, ANR-10-LABX-17, Department of Anaesthesiology and Critical Care Medicine, DMU PARABOL, CHU Bichat-Claude Bernard, AP-HP, Université de Paris, Paris, France.

Severe intra-abdominal infection commonly requires intensive care. Mortality is high and is mainly determined by disease-specific characteristics, i.e. Read More

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Evolving case of emphysematous pyelonephritis in a second renal allograft.

Urol Case Rep 2021 Sep 31;38:101663. Epub 2021 Mar 31.

Department of Urology, New York Medical College/Westchester Medical Center, Valhalla, NY, USA.

Emphysematous pyelonephritis is an acute necrotizing infection with gas in the kidney that portends a poor prognosis. Patients present with sepsis, requiring fluid resuscitation, glucose control, and broad-spectrum antibiotics. Surgical intervention ranges from relief of urinary obstruction (nephrostomy tube or stent), percutaneous drainage or nephrectomy. Read More

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September 2021

Acute pylephlebitis secondary to perforated sigmoid diverticulitis: A case report.

Radiol Case Rep 2021 Jun 17;16(6):1504-1507. Epub 2021 Apr 17.

Maidstone and Tunbridge Wells NHS Trust, Kent, UK.

Pylephlebitis is defined as the development of portal venous thrombosis secondary to intra-abdominal infection or inflammation. We present the case of a 69-year-old male with pylephlebitis who attended the Emergency Department with nonspecific abdominal pain, rigors and deranged liver function tests. After an initial negative ultrasound study, computed tomography (CT) scanning demonstrated perforated diverticulitis with an associated thrombus within the portal venous system. Read More

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Slow down with that full bladder: A case report describing an intraperitoneal bladder rupture repaired laparoscopically.

Int J Surg Case Rep 2021 May 27;82:105901. Epub 2021 Apr 27.

Dr George Mukhari Academic Hospital, South Africa.

Introduction: Intraperitoneal bladder rupture requires surgical repair (1). Historically these injuries were treated via laparotomy and open repair (1). There are only a few case reports of laparoscopic bladder repair reported in the literature. Read More

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Nutrition in open abdomen.

Rozhl Chir 2021 ;100(2):83-87

Open abdomen is known as a serious consequence of various intra-abdominal pathologies. Initially, patients often have a life-threatening condition, sepsis or septic shock. Severe stress related malnutrition, mineral and fluid imbalance develop as metabolic consequences. Read More

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Tertiary peritonitis: A disease that should not be ignored.

World J Clin Cases 2021 Apr;9(10):2160-2169

Instituto Multidisciplinar em Saúde, Universidade Federal da Bahia, Vitória da Conquista 45029-094, Bahia, Brazil.

Intra-abdominal infections can be classified into uncomplicated or complicated (peritonitis). Peritonitis is divided into primary, secondary, and tertiary. Tertiary peritonitis is the less common but the most severe among peritonitis stratifications, being defined as a recurrent intra-abdominal infection that occurs 48 h after a well-succeeded control of a secondary peritonitis. Read More

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Incidence of a subsequent carbapenem-resistant Enterobacteriaceae infection after previous colonisation or infection: a prospective cohort study.

Int J Antimicrob Agents 2021 Jun 20;57(6):106340. Epub 2021 Apr 20.

Department of Pharmacy, Singapore General Hospital, Outram Road, Singapore, Singapore; Emerging Infectious Diseases Programme, Duke-National University of Singapore Medical School, Singapore, Singapore; Singhealth Duke-NUS Medicine Academic Clinical Programme, Singapore, Singapore. Electronic address:

Objectives: In patients with a history of carbapenemase-producing, carbapenem-resistant Enterobacteriaceae (CP-CRE), the need for CP-CRE targeted treatment in subsequent sepsis episodes is unclear. This study aimed to characterise the incidence of subsequent CP-CRE infective episodes in individuals with prior CP-CRE colonisation and/or infection, and identify predictors for these subsequent CP-CRE infections.

Methods: All adult inpatients with CP-CRE detected from any site between June 2012 and May 2014 at a tertiary-care hospital were prospectively followed for two years to assess for any subsequent CP-CRE infections. Read More

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Prognosis and Risk Factors of Sepsis Patients in Chinese Icus: A Retrospective Analysis of A Cohort Database.

Shock 2021 Mar 31. Epub 2021 Mar 31.

Department of Critical Care Medicine, Fuxing Hospital, Capital Medical University. 20A Fuxingmenwai Street, Xicheng District, Beijing 100038, China Department of Statistics, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China. Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University. 10 Xitoutiao, Youanmenwai, Fengtai District, Beijing 100069, China Department of Critical Care Medicine, Xuanwu Hospital, Capital Medical University. 45 Changchun Road, Xicheng District, Beijing 100045, China.

Background: Sepsis-3 proposed a new definition of septic shock that excluded patients without hyperlactacidemia. The data from China might help to elucidate the prognosis of this special patient group.

Objective: To study the clinical prognosis and factors affecting patients with sepsis based on data from Chinese intensive care units (ICUs). Read More

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The Essential Involvement of the Omentum in the Peritoneal Defensive Mechanisms During Intra-Abdominal Sepsis.

Front Immunol 2021 18;12:631609. Epub 2021 Mar 18.

Department of Microbiology and Immunology, Trauma Research Center, Fourth Medical Center of the Chinese PLA General Hospital, Beijing, China.

Although the abilities of the omentum to alleviate inflammation and prevent infection have been revealed over the past decades, the underlying mechanisms remain largely unelucidated. Here, we demonstrated that the mortality of mice exposed to cecal ligation and puncture (CLP) and omentectomy was remarkably increased compared to those treated with CLP alone. Moreover, the efficacy of the omentum was associated with an impairment in intraperitoneal bacterial clearance together with an increase in the expression of proinflammatory cytokines. Read More

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The Need of Enterococcal Coverage in Severe Intra-Abdominal Infection: Evidence from Animal Study.

J Clin Med 2021 Mar 2;10(5). Epub 2021 Mar 2.

Department of Emergency Medicine, CHA University School of Medicine, Seongnam 13497, Korea.

Intra-abdominal infection (IAI) is a common and important cause of infectious mortality in intensive care units. Adequate source control and appropriate antimicrobial regimens are key in the management of IAI. In community-acquired IAI, guidelines recommend the use of different antimicrobial regimens according to severity. Read More

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Surveillance for Healthcare-Associated Infections: Hospital-Onset Adult Sepsis Events versus Current Reportable Conditions.

Clin Infect Dis 2021 Mar 29. Epub 2021 Mar 29.

Department of Population Medicine, Harvard Medical School / Harvard Pilgrim Health Care Institute, Boston, MA, USA.

Background: U.S. hospitals are required by CMS to publicly report CLABSI, CAUTI, C. Read More

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Skin-only closure as a temporary abdominal closure technique in a rural setting - exploring role and safety profile.

S Afr J Surg 2021 Mar;59(1):20-24

Ngwelezane General Hospital, South Africa and Department of Surgery, University of KwaZulu-Natal, South Africa.

Background: Acute laparotomy for trauma or sepsis often prevents definitive closure due to need for relook laparotomy or to prevent abdominal compartment syndrome. Skin-only closure is widely used in our setting. In this study, we review the safety and effectiveness of this technique. Read More

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Predictive value of immune cell counts and neutrophil-to-lymphocyte ratio for 28-day mortality in patients with sepsis caused by intra-abdominal infection.

Burns Trauma 2021 Jan 22;9:tkaa040. Epub 2021 Mar 22.

Medical school of Chinese PLA, No. 28 Fuxing Road, Haidian District, Beijing 100853, China.

Background: The current study aimed to evaluate the value of immune cell counts and neutrophil-to-lymphocyte ratio (NLR) when attempting to predict 28-day mortality.

Methods: We conducted an observational retrospective study that included consecutive septic patients. Severity scores on the first day and peripheral circulating immune cell counts (at day 1, day 3, day 5 and day 7 of admission) were collected during each patient's emergency intensive care unit stay. Read More

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January 2021

Adjunctive host-directed therapies for pulmonary tuberculosis: a prospective, open-label, phase 2, randomised controlled trial.

Lancet Respir Med 2021 Mar 16. Epub 2021 Mar 16.

The Aurum Institute, Johannesburg, South Africa; Department of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, UK.

Background: Current tuberculosis treatments leave patients with clinically significant lung injury and increased all-cause mortality post-cure. Adjunctive host-directed therapies could protect the lungs, improve long-term survival, and shorten treatment duration; however, few have been tested clinically. Therefore, we aimed to assess the safety and preliminary efficacy of four host-directed therapies for tuberculosis. Read More

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Timed Controlled Repeated Rotation of the CAR-170-C NXSTAGE Chronic Cartridge Hemodialysis Filter: A Novel Approach to Enabling Heparin-Free Frequent Daily Home Hemodialysis.

Mayo Clin Proc Innov Qual Outcomes 2021 Feb 6;5(1):219-224. Epub 2020 Nov 6.

Home Dialysis Unit, University of Vermont Medical Center, Burlington, VT.

Heparin-free hemodialysis is often warranted in postoperative states, bleeding diathesis, and critically ill patients. Conventionally, this is achieved through normal saline flushes or regional citrate anticoagulation. An 87-year-old white man with end-stage renal disease and atrial fibrillation, who was taking warfarin and using maintenance home hemodialysis (HHD) with an NxStage machine, underwent laparoscopic appendicectomy. Read More

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February 2021

Immune Resolution Dilemma: Host Antimicrobial Factor S100A8/A9 Modulates Inflammatory Collateral Tissue Damage During Disseminated Fungal Peritonitis.

Front Immunol 2021 26;12:553911. Epub 2021 Feb 26.

Department of Clinical Microbiology, Umeå Centre for Microbial Research (UCMR), Umeå University, Umeå, Sweden.

Intra-abdominal infection (peritonitis) is a leading cause of severe disease in surgical intensive care units, as over 70% of patients diagnosed with peritonitis develop septic shock. A critical role of the immune system is to return to homeostasis after combating infection. S100A8/A9 (calprotectin) is an antimicrobial and pro-inflammatory protein complex used as a biomarker for diagnosis of numerous inflammatory disorders. Read More

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February 2021

Probiotic Properties of Alcaligenes faecalis Isolated from Argyrosomus regius in Experimental Peritonitis (Rat Model).

Probiotics Antimicrob Proteins 2021 Mar 13. Epub 2021 Mar 13.

Group of Fish Health and Infectious Diseases, Universitary Institute of Animal Health and Food Safety (IUSA), University of Las Palmas de Gran Canaria, Carretera de Trasmontaña s/n, 35416, Arucas, Spain.

A strain of Alcaligenes faecalis A12C (A. faecalis A12C) isolated from Argyrosomus regius is a probiotic in fish. Previous experiments showed that A. Read More

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Accuracy of Procalcitonin Levels for Diagnosis of Culture-Positive Sepsis in Critically Ill Trauma Patients: A Retrospective Analysis.

Cureus 2021 Jan 29;13(1):e12988. Epub 2021 Jan 29.

Internal Medicine, Liaquat National Hospital, Karachi, PAK.

Background Abdominal trauma and intra-abdominal sepsis are associated with significant morbidity and mortality. Microcirculation in the gut is disrupted in hemorrhagic and septic shock leading to tissue hypoxia, and the damaged gut acts as a reservoir rich in inflammatory mediators and provides a continual source of inflammation to the systemic circulation leading to sepsis. Sepsis is defined as the presence (probable or documented) of infection together with a systemic inflammatory response to infection. Read More

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January 2021

Early Initiation of a Standardized Open Abdomen Treatment With Vacuum Assisted Mesh-Mediated Fascial Traction Achieves Best Results.

Front Surg 2020 9;7:606539. Epub 2021 Feb 9.

Department of General and Hepatopancreaticobiliary Surgery and Liver Transplantation, Ghent University Hospital, Ghent, Belgium.

The open abdomen (OA) is an important approach for managing intra-abdominal catastrophes and continues to be the standard of care. Complete fascial closure is an essential treatment objective and can be achieved by the use of different dynamic closure techniques. Both surgical technique and-decision making are essential for optimal patient outcome in terms of fascial closure. Read More

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February 2021

Membrane Permeant Inhibitor of Myosin Light Chain Kinase Worsens Survival in Murine Polymicrobial Sepsis.

Shock 2021 Feb 17. Epub 2021 Feb 17.

Department of Surgery and Emory Critical Care Center, Emory University School of Medicine, Atlanta, Georgia, USA Department of Critical Care Medicine, The First Affiliated Hospital, China Medical University, Shenyang, China Department of Emergency and Critical Care Medicine, Chiba University Graduate School of Medicine, Chiba, Japan Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA Department of Pathology and Laboratory Medicine, Emory University Department of Surgery and Emory Transplant Center, Emory University School of Medicine, Atlanta, GA, USA.

Abstract: Sepsis-induced intestinal hyperpermeability is mediated by disruption of the epithelial tight junction, which is closely associated with the peri-junctional actin-myosin ring. Genetic deletion of myosin light chain kinase (MLCK) reverses intestinal hyperpermeability and improves survival in a murine model of intra-abdominal sepsis. In an attempt to determine whether these findings could be translated using a more clinically relevant strategy, this study aimed to determine if pharmacologic inhibition of MLCK using the membrane permeant inhibitor of MLCK (PIK) improved gut barrier function and survival following sepsis. Read More

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February 2021

Patterns, price and predictors of successful empiric antibiotic therapy in a real-world setting.

J Clin Pharm Ther 2021 Jun 7;46(3):846-852. Epub 2021 Feb 7.

Department of Internal Medicine, University Hospital of Patras, Patras, Greece.

What Is Known And Objective: Prompt and appropriate empiric antibiotic therapy (EAT) remains the cornerstone of successful outcomes, while the majority of blood cultures do not identify pathogen. We aimed to report patterns of EAT and its impact on outcomes and associated medical costs, while exploring predictors of its success in a real-world setting.

Methods: We retrospectively utilized the prospective registry of the medical unit of a tertiary university hospital, including patients admitted with diagnosis of infection between 1st May 2016 and 1st May 2018. Read More

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Development of a large animal model of lethal polytrauma and intra-abdominal sepsis with bacteremia.

Trauma Surg Acute Care Open 2021 1;6(1):e000636. Epub 2021 Feb 1.

Surgery, Michigan Medicine, University of Michigan, Ann Arbor, Michigan, USA.

Background: Trauma and sepsis are individually two of the leading causes of death worldwide. When combined, the mortality is greater than 50%. Thus, it is imperative to have a reproducible and reliable animal model to study the effects of polytrauma and sepsis and test novel treatment options. Read More

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February 2021