2,024 results match your criteria Intra-abdominal Sepsis


Ceftazidime-Avibactam Combination Therapy Compared to Ceftazidime-Avibactam Monotherapy for the Treatment of Severe Infections Due to Carbapenem-Resistant Pathogens: A Systematic Review and Network Meta-Analysis.

Antibiotics (Basel) 2020 Jul 7;9(7). Epub 2020 Jul 7.

Department of Surgical, Oncological and Oral Science (Di.Chir.On.S.). Section of Anesthesia, Analgesia, Intensive Care and Emergency. Policlinico Paolo Giaccone, University of Palermo, 90127 Palermo, Italy.

Ceftazidime-avibactam (CZA) is a novel beta-lactam beta-lactamase inhibitor combination approved for the treatment of complicated urinary tract infections, complicated intra-abdominal infections, and for hospital-acquired/ventilator-associated pneumonia. The aim of this systematic review (PROSPERO registration number: CRD42019128927) was to evaluate the effectiveness of CZA combination therapy versus CZA monotherapy in the treatment of severe infections. The databases included in the search, until February 12th, 2020, were MEDLINE by PubMed, EMBASE, and The Cochrane Central Register of Controlled Trials. Read More

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http://dx.doi.org/10.3390/antibiotics9070388DOI Listing

International Survey on Determinants of Antibiotic Duration and Discontinuation in Pediatric Critically Ill Patients.

Pediatr Crit Care Med 2020 Jun 29. Epub 2020 Jun 29.

Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, QC, Canada.

Objectives: We hypothesized that antibiotic use in PICUs is based on criteria not always supported by evidence. We aimed to describe determinants of empiric antibiotic use in PICUs in eight different countries.

Design: Cross-sectional survey. Read More

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http://dx.doi.org/10.1097/PCC.0000000000002397DOI Listing

A Potential Mechanism of Tumor Progression during Systemic Infections Via the Hepatocyte Growth Factor (HGF)/c-Met Signaling Pathway.

J Clin Med 2020 Jul 1;9(7). Epub 2020 Jul 1.

Department of Surgery, National Defense Medical College; 3-2 Namiki, Tokorozawa 359-8513, Japan.

Background: Increasing evidence has demonstrated that postoperative infectious complications (PICs) after digestive surgery are significantly associated with negative long-term outcomes; however, precise mechanisms of how PICs affect the poor long-term survival remain unclear. Here, we focused on the hepatocyte growth factor (HGF)/c-Met signaling pathway as one of those mechanisms. In the clinical setting, serum HGF levels were measured in the patients with sepsis and those with PICs after undergoing esophagectomy. Read More

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http://dx.doi.org/10.3390/jcm9072074DOI Listing

Predictors for delayed antibiotic administration among bacteraemic patients in the Emergency Department: differences between medical and surgical interns.

Eur J Clin Invest 2020 Jun 21:e13324. Epub 2020 Jun 21.

Department of Internal Medicine, Hospital of Jura, Delémont, Switzerland.

Background: Bloodstream infections (BSIs) have been associated with high mortality. The aim of the study was to identify predictors of early (within 3 hours from triage) administration of first antibiotic dose among patients evaluated in the Emergency Department (ED) with BSI and their role in mortality.

Materials And Methods: All adult patients with BSI at the ED of the Hospital of Jura, Switzerland during a three year period (July 2014 to June 2017) were included. Read More

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http://dx.doi.org/10.1111/eci.13324DOI Listing

Adipose-Derived Inflammatory and Coagulant Mediators in Patients with Sepsis.

Shock 2020 Jun 2. Epub 2020 Jun 2.

Aging and Critical Care Research Laboratory, Departments of.

Results from preclinical sepsis studies using rodents are often criticized as not being reproducible in humans. Using a murine model, we previously reported that visceral adipose tissues (VAT) are highly active during the acute inflammatory response, serving as a major source of inflammatory and coagulant mediators. The purpose of this study was to determine whether these findings are recapitulated in patients with sepsis and to evaluate their clinical significance. Read More

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http://dx.doi.org/10.1097/SHK.0000000000001579DOI Listing

Role of Static and Dynamic Intra-abdominal Pressure Monitoring in Acute Pancreatitis: A Prospective Study on Its Impact.

Pancreas 2020 May/Jun;49(5):663-667

From the Institute of Gastrosciences and Liver.

Objective: This study was aimed to determine the relationship between static and dynamic intra-abdominal pressure (IAP) with the mortality and outcome of acute pancreatitis.

Methods: From July 2017 to December 2018, 150 patients admitted at the Institute of Gastrosciences and Liver and diagnosed as acute pancreatitis were included in the study. Intra-abdominal pressure was measured for the first few days, and mean value of day 1 (static IAP) and highest value on day 2 and day 3 (dynamic IAP) were calculated and categorized into intra-abdominal hypertension and abdominal compartment syndrome. Read More

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http://dx.doi.org/10.1097/MPA.0000000000001544DOI Listing

Morbidity and Mortality of Typhoid Intestinal Perforation Among Children in Sub-Saharan Africa 1995-2019: A Scoping Review.

World J Surg 2020 May 19. Epub 2020 May 19.

Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD, USA.

Background: Typhoid fever incidence and complications, including intestinal perforation, have declined significantly in high-income countries, with mortality rates <1%. However, an estimated 10.9 million cases still occur annually, most in low- and middle-income countries. Read More

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http://dx.doi.org/10.1007/s00268-020-05567-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236653PMC

Discontinuation of Glycopeptides in Patients with Culture Negative Severe Sepsis or Septic Shock: A Propensity-Matched Retrospective Cohort Study.

Antibiotics (Basel) 2020 May 13;9(5). Epub 2020 May 13.

Biostatistics Collaboration Unit, Yonsei University College of Medicine, Seoul 03722, Korea.

Implementation of antibiotic stewardship is difficult in patients with sepsis because of severity of disease. We evaluated the impact of glycopeptide discontinuation (GD) in patients with culture negative severe sepsis or septic shock who received glycopeptides as initial empiric antibiotic therapy at admission. We conducted a single center retrospective cohort study between January 2010 and March 2018. Read More

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http://dx.doi.org/10.3390/antibiotics9050250DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7277931PMC

Open abdomen closure methods for severe abdominal sepsis: a retrospective cohort study.

Eur J Trauma Emerg Surg 2020 May 6. Epub 2020 May 6.

Department of General Surgery, San Giovanni Addolorata Hospital, Rome, Italy.

Purpose: The open abdomen (OA) procedure as part of damage control surgery represents a significant surgical advance in severe intra-abdominal infections. Major techniques used for OA are negative pressure wound therapy (NPWT) and non-NPWT. The aim of this retrospective study is to evaluate the effects of different abdominal closure methods and their outcomes in patients presenting with abdominal sepsis treated with OA. Read More

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http://dx.doi.org/10.1007/s00068-020-01379-0DOI Listing

Respiratory consequences of intra-abdominal hypertension.

Minerva Anestesiol 2020 May 5. Epub 2020 May 5.

Alma Mater Studiorum, Dipartimento di Scienze Biomediche e Neuromotorie, Università di Bologna, Bologna, Italy.

Intra-abdominal hypertension (IAH) is a common complication in critically ill patients that may lead to multiorgan failure and is associated to worse outcome. Respiratory failure is among the most important consequences of IAH and it is originated by different mechanisms, such as chest wall elastance increase, functional residual capacity reduction, compression atelectasis and lung edema formation through reduction in lymphatic drainage. Many experimental studies showed that total lung capacity and functional residual capacity can be decreased by 40% during abdominal hypertension, while respiratory system and chest wall pressure-volume curves can be significantly shifted downward and to the right. Read More

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http://dx.doi.org/10.23736/S0375-9393.20.14325-6DOI Listing

Clinical characteristics and risk factors of tigecycline-associated hypofibrinogenaemia in critically ill patients.

Eur J Clin Pharmacol 2020 Jul 30;76(7):913-922. Epub 2020 Apr 30.

Intensive Care Unit, The First Affiliated Hospital, College of Medicine, Zhejiang University, 79 Qingchun Road, Hangzhou, 310003, People's Republic of China.

Purpose: To analyze the clinical features and risk factors of tigecycline-associated hypofibrinogenaemia and study whether cefoperazone/sulbactam combined with tigecycline aggravates coagulopathy or hypofibrinogenaemia.

Methods: A retrospective case-control study of patients with severe infection who were treated with tigecycline was conducted. Patients were assigned to the hypofibrinogenaemia group (< 2. Read More

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http://dx.doi.org/10.1007/s00228-020-02860-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7224009PMC

Intraperitoneal Phototherapy Suppresses Inflammatory Reactions in a Surgical Model of Peritonitis.

J Surg Res 2020 Aug 13;252:231-239. Epub 2020 Apr 13.

Department of Gastroenterological and Pediatric Surgery, Oita University Faculty of Medicine, Oita, Japan.

Background: Standard treatment for diffuse peritonitis due to colorectal perforation may be insufficient to suppress inflammatory reaction in sepsis. Thus, developing new treatments is important. This study aimed to examine whether intraperitoneal irradiation by artificial sunlight suppresses inflammatory reaction in a lipopolysaccharide (LPS)-induced peritonitis model after surgical treatments. Read More

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http://dx.doi.org/10.1016/j.jss.2020.03.020DOI Listing

Older Sepsis Survivors Suffer Persistent Disability Burden and Poor Long-Term Survival.

J Am Geriatr Soc 2020 Apr 15. Epub 2020 Apr 15.

Department of Surgery, University of Florida, Gainesville, Florida, USA.

Objectives: Sepsis has been called a "disease of the elderly," and as in-hospital mortality has decreased, more sepsis survivors are progressing into poorly characterized long-term outcomes. The purpose of this study was to describe the current epidemiology of sepsis in older adults compared with middle-aged and young adults.

Design: Prospective longitudinal study with young (≤45 years), middle-aged (46-64 years), and older (≥65 years) patient groups. Read More

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http://dx.doi.org/10.1111/jgs.16435DOI Listing

A Case of Morganella morganii-induced Fetal Demise.

Cureus 2020 Mar 3;12(3):e7169. Epub 2020 Mar 3.

Internal Medicine, Marshall University, Huntington, USA.

Morganella morganii is a rare opportunistic pathogen that is known to cause urinary tract and intra-abdominal infections. Per our literature review, there are few case reports of neonatal sepsis associated with this organism but to our knowledge, there are no case reports of Morganella morganii causing fetal demise in published literature in the Englishlanguage. In this case report, we present a case of a 34-year-old pregnant woman who had a hospital course complicated by Morganella morganii, which eventually led to stillbirth. Read More

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http://dx.doi.org/10.7759/cureus.7169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7117615PMC

Rectal stump management in inflammatory bowel disease: a cohort study, systematic review and proportional analysis of perioperative complications.

Tech Coloproctol 2020 07 31;24(7):671-684. Epub 2020 Mar 31.

Department of Surgery, Royal Devon and Exeter NHS Foundation Trust, Exeter, UK.

Background: The aim of this study was to analyse local single-institution data and perform a systematic review of the literature to calculate precise risk estimates of rectal stump-related morbidity and mortality following subtotal colectomy in patients with inflammatory bowel disease (IBD), including Crohn's colitis, ulcerative colitis and indeterminate colitis.

Methods: Institutional information systems were interrogated to obtain local patient data. A systematic review of MEDLINE and EMBASE was performed to identify relevant articles. Read More

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http://dx.doi.org/10.1007/s10151-020-02188-8DOI Listing

Factors associated with the development of septic shock in patients with candidemia: a post hoc analysis from two prospective cohorts.

Crit Care 2020 03 26;24(1):117. Epub 2020 Mar 26.

Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Marañón, Madrid, Spain.

Background: Almost one third of the patients with candidemia develop septic shock. The understanding why some patients do and others do not develop septic shock is very limited. The objective of this study was to identify variables associated with septic shock development in a large population of patients with candidemia. Read More

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http://dx.doi.org/10.1186/s13054-020-2793-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7099832PMC

Primary mesenteric fibromatosis: A single Center experience.

Ann Ital Chir 2020 Mar 3;9. Epub 2020 Mar 3.

Aim: Primary mesenteric fibromatosis is a rare, locally invasive, non-metastasizing type of intra-abdominal fibromatoses with a very high rate of recurrence. In this study, we aimed to present our surgical approach, tumor characteristics, clinical presentation and long-term follow-up results in cases of primary mesenteric fibromatosis.

Material And Metods: The data collected from 11 patients who underwent surgery due to primary mesenteric fibromatosis in our clinic between 2010 and 2019 were analyzed retrospectively. Read More

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Are Biologics Safe in the Immediate Postoperative Period? A Single-Center Evaluation of Consecutive Crohn's Surgical Patients.

Dis Colon Rectum 2020 Jul;63(7):934-943

Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota.

Background: There is no study to date examining the safety of initiating or restarting biologic therapy after major abdominal surgery for Crohn's disease.

Objective: The purpose of this study was to determine differences in the rates of 90-day superficial surgical site infections, intra-abdominal sepsis, and overall postoperative infectious complications among patients who were initiated on or restarted a biologic within 90 days postoperatively compared with those who were not.

Design: This was a retrospective cohort study. Read More

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http://dx.doi.org/10.1097/DCR.0000000000001649DOI Listing

[Epidemiology and clinical of infections and colonizations caused by Enterobacterales producing carbapenemases in a tertiary hospital].

Rev Esp Quimioter 2020 Apr 9;33(2):122-129. Epub 2020 Mar 9.

Ilduara Pintos-Pascual, Hospital Universitario Puerta de Hierro. Calle Manuel de Falla, 1, 28222 Majadahonda, Madrid, Spain.

Objective: To describe the epidemiology of Enterobacterales producing carbapenemases (EPC) in a tertiary hospital.

Methods: A retrospective observational study, all patients with a positive sample for EPC treated in hospitalization or in the Emergency Department were included, between January 1, 2014 and December 31, 2016.

Results: A total of 272 patients (316 samples) were included: 155 (57%) male. Read More

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http://dx.doi.org/10.37201/req/086.2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7111233PMC

Next-generation sequencing of microbial cell-free DNA for rapid noninvasive diagnosis of infectious diseases in immunocompromised hosts.

F1000Res 2019 26;8:1194. Epub 2019 Jul 26.

Division of Hematology Oncology, University of Miami Miller School of Medicine, Miami, FL, 33136, USA.

Cell-free DNA (cfDNA) sequencing has emerged as an effective laboratory method for rapid and noninvasive diagnosis in prenatal screening testing, organ transplant rejection screening, and oncology liquid biopsies but clinical experience for use of this technology in diagnostic evaluation of infections in immunocompromised hosts is limited.  We conducted an exploratory study using next-generation sequencing (NGS) for detection of microbial cfDNA in a cohort of ten immunocompromised patients with febrile neutropenia, pneumonia or intra-abdominal infection.  Pathogen identification by cfDNA NGS demonstrated positive agreement with conventional diagnostic laboratory methods in 7 (70%) cases, including patients with proven/probable invasive aspergillosis, pneumonia, bacteremia, Cytomegalovirus and Adenovirus viremia. Read More

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http://dx.doi.org/10.12688/f1000research.19766.4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6883395PMC

Prophylactic Anti-Cytomegalovirus Hyperimmunoglobulin in Critically Ill Liver Transplant Patients: Impact on Early Immunology and Survival.

J Clin Med 2020 Feb 29;9(3). Epub 2020 Feb 29.

Institute of Pathology, Helios Klinikum Berlin, Berlin 14165, Germany.

Background: Anti-cytomegalovirus hyperimmunoglobulin (CMVIg) was shown to provide beneficial immunodulatory properties beyond antiviral efficacies. The aim of this retrospective study was to assess the impact of prophylactic CMVIg treatment on early outcome following liver transplantation (LT) in critically ill patients.

Methods: Forty-three cirrhotic patients requiring pre-LT intensive care due to multiorgan failure were analyzed. Read More

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http://dx.doi.org/10.3390/jcm9030656DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7141244PMC
February 2020

Impact of time to antibiotic therapy on clinical outcome in patients with bacterial infections in the emergency department: implications for antimicrobial stewardship.

Clin Microbiol Infect 2020 Feb 29. Epub 2020 Feb 29.

Department of Medical Sciences, Uppsala University, Uppsala, Sweden. Electronic address:

Background: Rapid initiation of antibiotic treatment is considered crucial in patients with severe infections such as septic shock and bacterial meningitis, but may not be as important for other infectious syndromes. A better understanding of which patients can tolerate a delay in start of therapy is important for antibiotic stewardship purposes.

Objectives: To explore the existing evidence on the impact of time to antibiotics on clinical outcomes in patients presenting to the emergency department (ED) with bacterial infections of different severity of illness and source of infection. Read More

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http://dx.doi.org/10.1016/j.cmi.2020.02.032DOI Listing
February 2020

Protocol for a parallel economic evaluation of a trial comparing two surgical strategies in severe complicated intra-abdominal sepsis: the COOL-cost study.

World J Emerg Surg 2020 Feb 21;15(1):15. Epub 2020 Feb 21.

Department of Critical Care Medicine, University of Calgary, 2500 University Drive NW, Calgary, Alberta, T2N 1 N4, Canada.

Background: The risk of death in severe complicated intra-abdominal sepsis (SCIAS) remains high despite decades of surgical and antimicrobial research. New management strategies are required to improve outcomes. The Closed Or Open after Laparotomy (COOL) trial investigates an open-abdomen (OA) approach with active negative pressure peritoneal therapy. Read More

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http://dx.doi.org/10.1186/s13017-020-00294-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7035651PMC
February 2020

Laparoscopic versus open approach for diffuse peritonitis from appendicitis ethiology: a subgroup analysis from the Physiological parameters for Prognosis in Abdominal Sepsis (PIPAS) study.

Updates Surg 2020 Mar 19;72(1):185-191. Epub 2020 Feb 19.

Department of Emergency and Trauma Surgery, Maggiore Hospital, Parma, Italy.

Diffuse peritonitis represents a life-threatening complication of acute appendicitis (AA). Whether laparoscopy is a safe procedure and presents similar results compared with laparotomy in case of complicated AA is still a matter of debate. The objective of this study is to compare laparoscopic (LA) and open appendectomy (OA) for the management of diffuse peritonitis caused by AA. Read More

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http://dx.doi.org/10.1007/s13304-020-00711-yDOI Listing

Intact Glycocalyx of Intestinal Mucosa in Intraabdominal Infection: an Investigation Using Blood Group Antigen.

Acta Med Indones 2019 Oct;51(4):331-337

Department of Surgery, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo Hospital, Jakarta, Indonesia.

Background: intestinal glycocalyx plays a role in bacterial translocation as the pathogenesis sepsis derived from intra-abdominal infections that vulnerable in certain blood types. However, the link between intestinal glycocalyx in specific types of blood groups and abdominal infections remains unknown. This study aims to find out the condition of intestinal glycocalyx in certain blood types with intraabdominal sepsis. Read More

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October 2019

Entero-atmospheric fistula migration: a new management alternative for complex septic open abdomen.

Anaesthesiol Intensive Ther 2020 ;52(1):56-62

Department of Surgery, Meilahti Hospital, University of Helsinki, Finland.

The open abdomen technique is a surgical strategy used in life-threatening conditions. After recognizing the morbidity and mortality attributed to abdominal compartment syndrome (ACS), several methods were developed to avoid this complication. The primary goal of temporary abdominal closure (TAC) is to create a tension-free closure of the abdomen without increasing intra-abdominal pressure. Read More

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http://dx.doi.org/10.5114/ait.2020.92748DOI Listing
January 2020

The impact of age and comorbidity on the postoperative outcomes after emergency surgical management of complicated intra-abdominal infections.

Sci Rep 2020 Jan 31;10(1):1631. Epub 2020 Jan 31.

Department of General and Digestive Surgery, Hospital Universitario Doctor Peset, Valencia, Spain.

Age-adjusted Charlson Comorbidity Index (a-CCI) score has been used to weight comorbid conditions in predicting adverse outcomes. A retrospective cohort study on adult patients diagnosed with complicated intra-abdominal infections (cIAI) requiring emergency surgery was conducted in order to elucidate the role of age and comorbidity in this scenario. Two main outcomes were evaluated: 90-day severe postoperative complications (grade ≥ 3 of Dindo-Clavien Classification), and 90-day all-cause mortality. Read More

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http://dx.doi.org/10.1038/s41598-020-58453-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6994579PMC
January 2020

Evaluation of Amikacin Pharmacokinetics in Critically Ill Patients with Intra-abdominal Sepsis.

Adv Pharm Bull 2020 Jan 11;10(1):114-118. Epub 2019 Dec 11.

Department of Clinical Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.

Although the current widespread use of amikacin is in intra-abdominal sepsis treatment, its pharmacokinetic changes in the present setting are not yet well known. This study was aimed to evaluate the amikacin pharmacokinetic profile in critically ill patients with intraabdominal sepsis compared to pneumosepsis. Adult septic patients received amikacin therapy were studied. Read More

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http://dx.doi.org/10.15171/apb.2020.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6983982PMC
January 2020

Neonatal and Infant Appendicitis.

Clin Perinatol 2020 Mar 17;47(1):183-196. Epub 2019 Oct 17.

Division of Pediatric Surgery, Medical College of Wisconsin, Children's Hospital of Wisconsin, 999 North 92nd Street, Suite CCC320, Milwaukee, WI 53226, USA.

Neonatal appendicitis is a rare disease with a high mortality rate. Appendicitis is difficult to diagnose in neonatal and infant populations because it mimics other more common conditions in these age groups. Furthermore, signs and symptoms of appendicitis are often nonspecific in nonverbal patients and a high index of suspicion is necessary to initiate the appropriate diagnostic work-up. Read More

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http://dx.doi.org/10.1016/j.clp.2019.10.004DOI Listing

Abdominal compartment syndrome: Often overlooked conditions in medical intensive care units.

World J Gastroenterol 2020 Jan;26(3):266-278

Department of Pulmonary Critical Care and Sleep Medicine, Texas A&M Health Science Center, Bryan, TX 77807, United States.

Intra-abdominal hypertension (IAH) and abdominal compartment syndrome are well recognized entities among surgical patients. Nevertheless, a number of prospective and retrospective observational studies have shown that IAH is prevalent in about half of the critically ill patients in the medical intensive care units (ICU) and has been widely recognized as an independent risk factor for mortality. It is alarming to note that many members of the critical care team in medical ICU are not aware of the consequences of untreated IAH and the delay in making the diagnosis leads to increased morbidity and mortality. Read More

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http://dx.doi.org/10.3748/wjg.v26.i3.266DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6969886PMC
January 2020

Non-operative treatment of hepatic trauma: A changing paradigm. A Six year review of liver trauma patient in a single institute.

J Pak Med Assoc 2020 Feb;70(Suppl 1)(2):S27-S32

Department of Surgery, Aga Khan University, Karachi, Pakistan.

Objective: To review the managing strategies of adult patients with liver trauma in a tertiary care hospital during a six years period.

Methods: The medical records of all patients admitted with a diagnosis of liver trauma from January 2012 to December 2017 in the Aga Khan University Hospital were retrospectively reviewed. The details of demographic, clinical, and outcome variables including morbidity and mortality rates were noted. Read More

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February 2020

Therapeutic Effects of Hyaluronic Acid in Peritonitis-Induced Sepsis in Mice.

Shock 2020 Jan 20. Epub 2020 Jan 20.

Department of Anesthesiology, University of California, San Francisco, San Francisco, California.

Intra-abdominal infection is the second most common cause of sepsis, and the mortality rate from abdominal sepsis remains high. High molecular weight (HMW) hyaluronic acid (HA) has been studied in sterile injury models as an anti-inflammatory and anti-permeability agent. This study evaluated the therapeutic effects of intraperitoneal HMW HA administration in mice with peritonitis-induced sepsis. Read More

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http://dx.doi.org/10.1097/SHK.0000000000001512DOI Listing
January 2020

Anastomotic healing in a rat model of peritonitis after non-steroidal anti-inflammatory drug administration.

Eur J Histochem 2020 Jan 10;64(1). Epub 2020 Jan 10.

Clinic of Surgery, Marche Polytechnic University, Ancona .

The tissue inflammatory response can influence the outcome of anastomotic healing. Anastomotic leakage represents a dreadful complication after gastrointestinal surgery, in particular sepsis and intra-abdominal infections impair the restorative process of colic anastomoses. It has been debated whether the administration of non-steroidal anti-inflammatory drugs (NSAIDs) is a risk factor for dehiscence, since many patients receive NSAIDs in the early postoperative period. Read More

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http://dx.doi.org/10.4081/ejh.2020.3085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6985910PMC
January 2020

Incidence, trends, and outcomes of infection sites among hospitalizations of sepsis: A nationwide study.

PLoS One 2020 13;15(1):e0227752. Epub 2020 Jan 13.

Department of Emergency Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.

Purpose: To determine the trends of infection sites and outcome of sepsis using a national population-based database.

Materials And Methods: Using the Nationwide Inpatient Sample database of the US, adult sepsis hospitalizations and infection sites were identified using a validated approach that selects admissions with explicit ICD-9-CM codes for sepsis and diagnosis/procedure codes for acute organ dysfunctions. The primary outcome was the trend of incidence and in-hospital mortality of specific infection sites in sepsis patients. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0227752PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6957188PMC

Impact of perioperative transfusions and sepsis on long-term oncologic outcomes after curative colon cancer resection. A retrospective analysis of a prospective database.

Gastroenterol Hepatol 2020 Feb 7;43(2):63-72. Epub 2020 Jan 7.

Department of Colorectal Surgery, Hospital Universitario y Politécnico La Fe, University of Valencia, Spain.

Objective: Intra-abdominal septic complications (IASC) affect short-term outcomes after surgery for colon cancer. Blood transfusions have been associated with worse short-term results. The role of IASC and blood transfusions on long-term oncologic results is still debated. Read More

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http://dx.doi.org/10.1016/j.gastrohep.2019.07.005DOI Listing
February 2020

Experimental Abdominal Sepsis: Sticking to an Awkward but Still Useful Translational Model.

Mediators Inflamm 2019 5;2019:8971036. Epub 2019 Dec 5.

General Surgery Department, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy.

Animal models are widely used to replicate human intra-abdominal infections. Different methodologies have been described and proposed in the scientific literature, including injection and surgical models. The aim of this review is to recapitulate the advantages and disadvantages of each method to help choose the most appropriate model for individual experimental purposes. Read More

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http://dx.doi.org/10.1155/2019/8971036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6915118PMC

Polymyxin B hemoperfusion as a feasible therapy after source control in abdominal septic shock.

World J Gastrointest Surg 2019 Dec;11(12):422-432

Division of Trauma and Surgical Critical Care, Department of Surgery, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 137-701, South Korea.

Background: Polymyxin B hemoperfusion (PMX-HP) has been used as a treatment for intra-abdominal septic shock by absorbing and removing endotoxins of gram-negative bacilli.

Aim: To investigate the clinical efficacy of PMX-HP in patients with gram-negative septic shock who underwent abdominal surgery.

Methods: From January 2012 to December 2018, patients who had septic shock secondary to peritonitis were enrolled. Read More

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http://dx.doi.org/10.4240/wjgs.v11.i12.422DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6912072PMC
December 2019

A 2-year-old with a hepatic abscess secondary to an ascending retrocecal appendicitis: case report and review of the literature.

Int J Emerg Med 2019 Dec 19;12(1):41. Epub 2019 Dec 19.

D.O. Assistant Clinical Professor, Beaumont Hospital, Botsford Campus, Teaching hospital of Michigan State University, Department of Emergency Medicine, Farmington Hills, MI, USA.

Background: Diagnosing appendicitis within the pediatric population can be challenging, whether it be a neonate with irritability or a toddler with flank pain. Symptoms may mimic a viral illness, constipation, urinary tract infection, or intussusception, all of which are more common in this age group when compared with appendicitis. While a ruptured appendicitis can result in an intra-abdominal abscess, peritonitis, and/or shock, the development of a pyogenic hepatic abscess is extremely rare. Read More

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http://dx.doi.org/10.1186/s12245-019-0260-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6923966PMC
December 2019

Prophylactic antibiotics for penetrating abdominal trauma.

Cochrane Database Syst Rev 2019 12 12;12:CD007370. Epub 2019 Dec 12.

University of the Witwatersrand, General Surgery/Trauma Unit, PO Box 91155, Auckland Park, Johannesburg, Gauteng, South Africa, 2006.

Background: Penetrating abdominal trauma occurs when the peritoneal cavity is breached. Routine laparotomy for penetrating abdominal injuries began in the 1800s, with antibiotics first being used in World War II to combat septic complications associated with these injuries. This practice was marked with a reduction in sepsis-related mortality and morbidity. Read More

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http://dx.doi.org/10.1002/14651858.CD007370.pub4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6907398PMC
December 2019

Are right-sided colectomies for neoplastic disease at increased risk of primary postoperative ileus compared to left-sided colectomies? A coarsened exact matched analysis.

Surg Endosc 2019 Dec 11. Epub 2019 Dec 11.

Division of Colon and Rectal Surgery, Jewish General Hospital, Montreal, QC, Canada.

Introduction: The objective of this study was to determine whether right-sided colectomies (RC) were associated with a higher incidence of primary postoperative ileus (pPOI) compared to left-sided colectomies (LC).

Methods: Patients who underwent elective colectomy for neoplastic disease between 2012 and 2016 were identified using the American College of Surgeons National Surgical Quality Improvement Program database. RC and LC were defined as having an ileocolic or colocolic/colorectal anastomosis, respectively. Read More

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http://dx.doi.org/10.1007/s00464-019-07318-4DOI Listing
December 2019

Traditional Chinese medicine bundle therapy for septic acute gastrointestinal injury: A multicenter randomized controlled trial.

Complement Ther Med 2019 Dec 11;47:102194. Epub 2019 Sep 11.

ICU, The First Affiliated Hospital, Zhejiang Chinese Medical University, Hangzhou, China. Electronic address:

Objective: Current conventional treatments for sepsis associated with acute gastrointestinal injury (AGI) have limited efficacy. This study aimed to study traditional Chinese medicine (TCM) bundle therapy (based on TCM syndrome differentiation) as add-on to conventional treatments on the incidence of AGI and on the prognosis of patients with sepsis.

Design: This was a prospective multicenter randomized single-blind controlled trial. Read More

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http://dx.doi.org/10.1016/j.ctim.2019.102194DOI Listing
December 2019

Compliance with the Surviving Sepsis Campaign guidelines for early resuscitation does not translate into improved outcomes in patients with surgical sepsis in South Africa.

S Afr J Surg 2019 Dec;57(4):8-12

Department of Surgery, University of KwaZulu-Natal, Durban, South Africa and Department of Surgery, University of the Witwatersrand, Johannesburg, South Africa.

Introduction: This project set out to audit our compliance with the 3-hour bundles of care for surgical sepsis and to interrogate how compliance or non-compliance impacts on the outcome of surgical sepsis in our institution.

Methods: All emergency surgical patients over the age of fifteen years were reviewed. All patients who fulfilled the ACCP/SCCM criteria for sepsis or septic shock, with a documented surgical source of infection, were identified for review. Read More

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December 2019

[Investigation of treatment and analysis of prognostic risk on enterocutaneous fistula in China: a multicenter prospective study].

Zhonghua Wei Chang Wai Ke Za Zhi 2019 Nov;22(11):1041-1050

Research Institute of General Surgery, East War Zone Hospital of PLA, Nanjing 210002, China.

To investigate the diagnosis and treatment for enterocutaneous fistula (ECF) in China, and to explore the prognostic factors of ECF. A multi-center cross-sectional study was conducted based on the Registration System of Chinese Gastrointestinal Fistula and Intra-Abdominal Infections to collect the clinical data of ECF patients from 54 medical centers in 22 provinces/municipalities from January 1, 2018 to December 31, 2018. The clinical data included patient gender, age, length of hospital stay, intensive care unit (ICU) admission, underlying diseases, primary diseases, direct causes of ECF, location and type of ECF, complications, treatment and outcomes. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1671-0274.2019.11.007DOI Listing
November 2019

Preventing kidney injury by avoiding fluid overload in patients with sepsis.

JAAPA 2019 Dec;32(12):40-45

At the time this article was written, Rebecca L. Dodd was a student in the doctor of medical science program at the University of Lynchburg in Lynchburg, Va. She now practices pulmonary and critical care medicine in the cardiac ICU at Mercy General Hospital in Sacramento, Calif. Mark E. Archambault is an associate professor in the doctor of medical science program, physician assistant education concentration, at the University of Lynchburg. The authors have disclosed no potential conflicts of interest, financial or otherwise.

The global epidemiologic burden of sepsis is difficult to ascertain. Sepsis affects more than 31.5 million people worldwide every year, potentially resulting in 5 million deaths. Read More

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http://dx.doi.org/10.1097/01.JAA.0000604904.81228.18DOI Listing
December 2019

Efficacy and safety of acupuncture as a complementary therapy for sepsis: A protocol of systematic review and meta-analysis.

Medicine (Baltimore) 2019 Nov;98(48):e18025

Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China.

Introduction: Sepsis is a physiological, pathological, and biochemical syndrome caused by infection. Acupuncture may be useful for sepsis. This systematic review aims to assess the efficacy and safety of acupuncture as a complementary therapy for sepsis. Read More

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http://dx.doi.org/10.1097/MD.0000000000018025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6890293PMC
November 2019

The Prognostic Value of Presepsin for Sepsis in Abdominal Surgery: A Prospective Study.

Shock 2020 07;54(1):56-61

Department of General, Visceral, and Transplant Surgery, Ludwig-Maximilians-University Munich, Munich, Germany.

Introduction: Rapid diagnosis accompanied by appropriate treatment is essential in the therapy of sepsis. However, there is no blood marker available, which reliably predicts sepsis and associated mortality. Therefore, the aim of the present study was to evaluate presepsin and endotoxin in comparison with established blood markers in patients undergoing emergency visceral surgery for abdominal infection. Read More

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http://dx.doi.org/10.1097/SHK.0000000000001479DOI Listing

Acute primary abdominal compartment syndrome due to Clostridium difficile induced toxic megacolon: a case report and review of the literature.

Anaesthesiol Intensive Ther 2019 ;51(4):273-282

Department of Intensive Care, University Hospital of Brussels (UZB), Jette, Belgium.

Background: Without timely diagnosis, acute primary abdominal compartment syndrome (ACS) is a potentially fatal syndrome and often goes unrecognized until severe symptoms appear. Early diagnosis may significantly improve the prognosis of these patients.

Case Presentation: We present the case of a 54-year-old man, successfully treated for acute myeloid leukemia with cytosine arabinoside, admitted to the intensive care unit with severe shock, refractory to standard therapy with antibiotics, fluid resuscitation, and vasopressors. Read More

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http://dx.doi.org/10.5114/ait.2019.89189DOI Listing
January 2019

Candida albicans Impacts Staphylococcus aureus Alpha-Toxin Production via Extracellular Alkalinization.

mSphere 2019 11 13;4(6). Epub 2019 Nov 13.

Department of Clinical Pharmacy and Translational Science, University of Tennessee Health Science Center, Memphis, Tennessee, USA

and are common causes of nosocomial infections with severe morbidity and mortality. Murine polymicrobial intra-abdominal infection (IAI) with and results in acute mortality dependent on the secreted cytolytic effector alpha-toxin. Here, we confirmed that alpha-toxin is elevated during polymicrobial growth compared to monomicrobial growth Therefore, this study sought to unravel the mechanism by which drives enhanced staphylococcal alpha-toxin production. Read More

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http://dx.doi.org/10.1128/mSphere.00780-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6854045PMC
November 2019
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Application of Negative Pressure Wound Therapy with Instillation and Dwell Time of the Open Abdomen: Initial Experience.

Cureus 2019 Sep 16;11(9):e5667. Epub 2019 Sep 16.

Epidemiology and Biostatistics, University of Texas Health Science Center, UT Health East Texas, Tyler, USA.

Recent therapeutic advances in the management of severe abdominal sepsis (SAS) have improved patient mortality and morbidity. However, SAS and its impact on multiple organ failure remain a serious, life-threatening condition with a high mortality rate. The open abdomen (OA) technique has become an effective alternative to repeat laparotomy. Read More

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http://dx.doi.org/10.7759/cureus.5667DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6823022PMC
September 2019

Risk factors of invasive candidiasis in critical cancer patients after various gastrointestinal surgeries: A 4-year retrospective study.

Medicine (Baltimore) 2019 Nov;98(44):e17704

For early diagnosis and treatment of invasive candidiasis (IC), the well-known risk factors may not apply in the intensive care unit (ICU). This retrospective study identified the risk factors predicting IC and candidemia in cancer patients under intensive care after gastrointestinal surgery.Enrolled were 229 cancer patients admitted to our oncology surgical ICU after gastrointestinal surgery between January 1, 2010 and October 31, 2014. Read More

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http://dx.doi.org/10.1097/MD.0000000000017704DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6946494PMC
November 2019