2,238 results match your criteria Intra-abdominal Sepsis


A novel rat model for the study of postoperative pancreatic fistula.

Lab Anim 2022 Jun 29:236772221107347. Epub 2022 Jun 29.

University of Washington, Seattle, USA.

While over the past several decades mortality after pancreatic surgery has decreased to <5%, postoperative morbidity remains remarkably high, ranging from 15% to 65%. The development of a postoperative pancreatic fistula (POPF) is a significant contributor to morbidity in patients undergoing pancreatic surgery. POPF can lead to life-threatening conditions such as intra-abdominal abscess, uncontrolled hemorrhage, sepsis, and death. Read More

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Scientific evidence of the duration of antibiotic treatment in intra-abdominal infections with surgical focus control.

Cir Esp (Engl Ed) 2022 Jun 24. Epub 2022 Jun 24.

Servicio de Cirugía General y Aparato Digestivo, Hospital del Mar de Barcelona, Spain.

A non-systematic review of the published scientific evidence has been carried out on the duration of empirical antibiotic treatment in surgical intra-abdominal infections (IIA) with effective focus control. Given the progressive increase in antibiotic resistance, it is urgent to have strategies to reduce the pressure on the microbiota. The American guidelines made by Mazuski et al. Read More

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Prevalence, Characteristics, and Determinants of Suboptimal Care in the Initial Management of Community-Onset Severe Bacterial Infections in Children.

JAMA Netw Open 2022 Jun 1;5(6):e2216778. Epub 2022 Jun 1.

Inserm UMR 1153, Obstetrical, Perinatal and Pediatric Epidemiology Research Team (Epopé), Centre of Research in Epidemiology and Statistics, Université Paris Cité, Paris, France.

Importance: Assessment of the quality of initial care is necessary to target priority actions that can reduce the still high morbidity and mortality due to community-onset severe bacterial infections (COSBIs) among children.

Objective: To study the prevalence, characteristics, and determinants of suboptimal care in the initial management of COSBIs.

Design, Setting, And Participants: This prospective, population-based, cohort study and confidential enquiry was conducted between August 2009 and January 2014 in western France, a region accounting for 15% of the French pediatric population (1 968 474 children aged 1 month to 16 years) and including 6 pediatric intensive care units (PICUs) and 35 emergency departments. Read More

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Impact on infectious outcomes during laparoscopic cholecystectomy with the use of home-made vs commercial gallbladder retrieval bag: a retrospective comparative study in a high-volume center.

Surg Endosc 2022 Jun 7. Epub 2022 Jun 7.

Universidad el Bosque, Bogotá, Colombia.

Background: Laparoscopic cholecystectomy (LC) is one of the most commonly performed emergency procedures, with approximately 600,000 patients undergoing the procedure every year in the United States. Although LC is associated with fewer complications when compared with open cholecystectomy, the risk for infectious complications, including surgical site infection and intra-abdominal abscess, remains a significant source of postoperative morbidity. The goal of this study is to determine whether the gallbladder retrieval technique during LC affects risk of infectious complications. Read More

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Therapeutic strategies in Crohn's disease in an emergency surgical setting.

World J Gastroenterol 2022 May;28(18):1902-1921

Department of Surgery, Fondazione Policlinico Universitario A Gemelli IRCCS, Rome 00168, Italy.

Crohn's disease (CD) remains a chronic, incurable disorder that presents unique challenges to the surgeon. Multiple factors must be considered to allow development of an appropriate treatment plan. Medical therapy often precedes or complements the surgical management. Read More

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Complicated Severe Appendicitis in a 58-Year-Old Female After COVID-19 Infection: A Coincidence or an Association?

Cureus 2022 May 3;14(5):e24706. Epub 2022 May 3.

Internal Medicine, St. Peter's University Hospital, New Brunswick, USA.

Acute appendicitis (AA) remains the most common cause of acute abdomen worldwide. Although overall mortality in developed countries is low, complication due to perforation, abscess formation, stump appendicitis and intra-abdominal sepsis is associated with increased morbidity. Throughout the COVID-19 pandemic, an increasing proportion of complicated appendicitis has been reported. Read More

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An Atypical Source of Persistent Fungemia in the Intensive Care Unit.

Am J Case Rep 2022 May 30;23:e936223. Epub 2022 May 30.

Department of Pulmonary, Critical Care and Allergy Medicine, Oregon Health and Science University, Portland, OR, USA.

BACKGROUND Candidemia is a common complication of critically ill and immunocompromised patients, with more than 50% associated mortality. Typical etiologies include valvular vegetations, intra-abdominal fluid collections, and central venous catheters. Treatment often entails surgical excision, but anticoagulation may be sufficient. Read More

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Prediction of fluid responsiveness. What's new?

Ann Intensive Care 2022 May 28;12(1):46. Epub 2022 May 28.

AP-HP, Service de médecine intensive-réanimation, Hôpital de Bicêtre, DMU 4 CORREVE, Inserm UMR S_999, FHU SEPSIS, CARMAS, Université Paris-Saclay, 78 rue du Général Leclerc, 94270, Le Kremlin-Bicêtre, France.

Although the administration of fluid is the first treatment considered in almost all cases of circulatory failure, this therapeutic option poses two essential problems: the increase in cardiac output induced by a bolus of fluid is inconstant, and the deleterious effects of fluid overload are now clearly demonstrated. This is why many tests and indices have been developed to detect preload dependence and predict fluid responsiveness. In this review, we take stock of the data published in the field over the past three years. Read More

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Predictive Role of Changes in Presepsin and Early Sepsis in ICU Patients After Abdominal Surgery.

J Surg Res 2022 May 24;278:207-215. Epub 2022 May 24.

Division of Trauma and Surgical Critical Care, Department of Surgery, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea. Electronic address:

Introduction: It is difficult to identify early sepsis after surgery due to postoperative inflammatory reactions. Presepsin, a glycoprotein expressed on the surface of innate immune cells, is produced during bacterial phagocytosis, and its level increases in the bloodstream of sepsis patients. We aimed to measure the differences between the diagnostic ability of presepsin and other biomarkers to identify postoperative sepsis and septic shock in acute period after major abdominal surgery. Read More

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Implantation of an Impedance Sensor for Early Detection of Gastrointestinal Anastomotic Leaks.

J Surg Res 2022 May 17;278:49-56. Epub 2022 May 17.

Department of Surgery, Rabin Medical Center, Petach Tiqva, Israel; Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.

Introduction: Accurate early diagnosis of a gastrointestinal anastomotic leak remains a challenge. When an anastomotic leak develops, the electrical properties of the tissue undergoing inflammatory processes change, resulting from the extravasation of inflammatory fluid and cellular infiltration. The method described here intends to provide a novel early anastomotic leak warning system based upon measurable changes in tissue impedance nearby an acute inflammatory process. Read More

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Efficacy and safety of acupuncture as a complementary therapy for sepsis: a systematic review and meta-analysis.

Acupunct Med 2022 May 17:9645284221086288. Epub 2022 May 17.

Shandong University of Traditional Chinese Medicine, Jinan, China.

Background: Sepsis is a life-threatening organ dysfunction caused by dysregulation of the host response to infection. Acupuncture is used for treatment of inflammatory diseases; however, its effectiveness and safety as a complementary therapy for sepsis has not been fully explored.

Methods: Data were retrieved from eight databases. Read More

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Multi-omic Profiling Reveals that Intra-abdominal-Hypertension-Induced Intestinal Damage Can Be Prevented by Microbiome and Metabolic Modulations with 5-Hydroxyindoleacetic Acid as a Diagnostic Marker.

mSystems 2022 Jun 16;7(3):e0120421. Epub 2022 May 16.

Department of Intensive Care Unit, Peking University Third Hospitalgrid.411642.4, Beijing, China.

Emerging evidence shows that modulation of the microbiome can suppress intra-abdominal hypertension (IAH)-induced intestinal barrier damage through the regulation of amino acid (AA) biosynthesis. Here, we investigated the protective effects of orally gavaged Lactobacillus acidophilus L-92 (L92) and a mixture of AA in rats with induced IAH. The results showed that both L92 and AA pretreatments effectively mitigated IAH-induced intestinal damage. Read More

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An Alternative Abdominal Closure Technique After Pediatric Liver Transplant: Bogota Bag Technique.

Exp Clin Transplant 2022 05;20(Suppl 3):53-55

From the Baskent University, Department of General Surgery, Division of Transplantation, Ankara, Turkey.

Objectives: In conditions such as large-for-size syndrome, postreperfusion hepatic edema, and intestinal edema, primary closure of the abdominal wall can cause respiratory complications and thrombosis of vascular structures. Here, we compared results of primary abdominal closure versus a temporary patch closure technique (the Bogota bag technique) in pediatric liver transplant recipients.

Materials And Methods: We performed primary abdominal closure in 295 recipients. Read More

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Comparison of Duration and Empiric Antibiotic Choice of Post-Operative Treatment in Abdominal Sepsis.

Surg Infect (Larchmt) 2022 Jun 9;23(5):444-450. Epub 2022 May 9.

Department of General, Visceral, Transplant, Vascular, and Paediatric Surgery, University Hospital of Würzburg, Würzburg, Germany.

Although abdominal foci are the second most common source of sepsis, only few studies focus on the optimal length of post-operative antibiotic therapy in critically ill patients with abdominal sepsis. The aim of this study was to compare the outcomes of short versus long antibiotic therapy as well as broad-spectrum penicillin versus carbapenem in patients with abdominal sepsis. We performed a single center retrospective study in patients with abdominal sepsis who underwent emergency surgery. Read More

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Spontaneous transvaginal intestinal evisceration in case of long-standing uterine prolapse.

BMC Surg 2022 May 4;22(1):157. Epub 2022 May 4.

Department of General Surgery, Unit of Gastrointestinal, Hepato-Biliary and Pancreatic Surgery, University Hospital "Alexandrovska", Sofia, Medical University of Sofia, 1 G.Sofiiski Str., 1431, Sofia, Bulgaria.

Background: Transvaginal intestinal evisceration is an extremely rare surgical emergency with potentially fatal consequences. Only a few more than 100 cases with this pathology have been described in the literature. Aetiology is also unclear and multifactoral. Read More

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Inhalation anaesthesia compared with total intravenous anaesthesia and postoperative complications in colorectal cancer surgery: an observational registry-based study.

Br J Anaesth 2022 Apr 27. Epub 2022 Apr 27.

Center for Surgical Science, Zealand University Hospital, Roskilde, Denmark; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.

Background: Postoperative complications are common after colorectal surgery, and possibly related to the type of anaesthesia. We aimed to determine associations between the type of anaesthesia and complications after colorectal cancer surgery using Danish registries.

Methods: Patients undergoing colorectal cancer surgery (2004-18) were identified in the Danish Colorectal Cancer Group Database. Read More

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Metastatic osteosarcoma bowel perforation secondary to chemotherapy-induced tumour necrosis.

BMJ Case Rep 2022 Apr 26;15(4). Epub 2022 Apr 26.

Sarcoma Unit, Chris O'Brien Lifehouse, Camperdown, New South Wales, Australia.

Osteosarcoma is the most common paediatric and adolescent primary bone malignancy and is highly chemosensitive. Gastrointestinal metastases from osteosarcomas are rare. Bowel perforation secondary to chemotherapy is a potential serious complication reported in ovarian, colorectal and haematological malignancies. Read More

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Epidemiology and age-related mortality in critically ill patients with intra-abdominal infection or sepsis: an international cohort study.

Int J Antimicrob Agents 2022 Jul 20;60(1):106591. Epub 2022 Apr 20.

Department of General Internal Medicine and Infectious Diseases, AZ Delta, Roeselare, Belgium; Department of Internal Medicine and Paediatrics, Ghent University, Ghent, Belgium.

Objective: To describe epidemiology and age-related mortality in critically ill older adults with intra-abdominal infection.

Methods: A secondary analysis was undertaken of a prospective, multi-national, observational study (Abdominal Sepsis Study, ClinicalTrials.gov #NCT03270345) including patients with intra-abdominal infection from 309 intensive care units (ICUs) in 42 countries between January and December 2016. Read More

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Cefazolin Might Be Adequate for Perioperative Antibiotic Prophylaxis in Intra-Abdominal Infections without Sepsis: A Quality Improvement Study.

Antibiotics (Basel) 2022 Apr 10;11(4). Epub 2022 Apr 10.

Department of General, Visceral, Transplant, Vascular and Pediatric Surgery, University Hospital of Würzburg, 97080 Würzburg, Germany.

Background: The adequate choice of perioperative antibiotic prophylaxis (PAP) could influence the risk of surgical site infections (SSIs) in general surgery. A new local PAP guideline was implemented in May 2017 and set the first-generation cefazolin (CFZ) instead the second-generation cefuroxime (CXM) as the new standard prophylactic antibiotic. The aim of this study was to compare the risk of SSIs after this implementation in intra-abdominal infections (IAIs) without sepsis. Read More

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Efficacy and Safety of Thoracic Epidural Analgesia in Patients With Acute Pancreatitis: A Narrative Review.

Cureus 2022 Mar 16;14(3):e23234. Epub 2022 Mar 16.

Anesthesia and Critical Care, Sultan Qaboos University Hospital, Muscat, OMN.

Patients admitted to the intensive care unit with moderate to severe acute pancreatitis carry significant morbidity and mortality. A few unfortunate patients in whom the initial line of treatment fails to show clinical improvement develop multiorgan dysfunction involving lungs (adult respiratory distress syndrome), renal failure, intra-abdominal infections, sepsis, and septic shock, which ultimately leads to prolonged hospitalization and a substantial cost of treatment. The acute abdominal pain experienced by these patients is excruciating and requires multimodal analgesia. Read More

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Fatal systemic emphysematous infection caused by : A case report.

World J Clin Cases 2022 Mar;10(8):2610-2615

Department of General Surgery, Lanzhou University Second Hospital, Lanzhou 730030, Gansu Province, China.

Background: Systemic emphysematous infection caused by ( ) is a rare but severe infection which can be lethal if the diagnosis is delayed.

Case Summary: We report a rare case of systemic emphysematous infection hematogenous dissemination from a liver abscess caused by , complicated by multiple organ dysfunction syndrome, septic shock, bacteremia, emphysematous cystitis, prostate and left seminal vesicle abscesses in a diabetic patient. The patient simultaneously presented with spontaneous pneumoperitoneum secondary to rupture of the emphysematous liver abscess. Read More

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The Fulminating Course of Infection Caused by : A Case Report.

Infect Drug Resist 2022 8;15:1645-1650. Epub 2022 Apr 8.

Department of Critical Care Medicine, Xijing Hospital, The Fourth Military Medical University, Xi'an, People's Republic of China.

, a Gram-negative bacillus found in warm saltwater environments, has been increasingly recognized as a human pathogen that can cause infection of the skin and soft tissue, ear, blood, and intra-abdominal. In this case, we report a infection that caused sepsis, renal insufficiency, cardiac dysfunction, fistula and massive pleural effusion after surgery in a 73-year-old man with cancer of the esophagus and cardia. Read More

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Antimicrobial treatment duration for uncomplicated bloodstream infections in critically ill children: a multicentre observational study.

BMC Pediatr 2022 04 5;22(1):179. Epub 2022 Apr 5.

Division of Infectious Diseases, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.

Background: Bloodstream infections (BSIs) cause significant morbidity and mortality in critically ill children but treatment duration is understudied. We describe the durations of antimicrobial treatment that critically ill children receive and explore factors associated with treatment duration.

Methods: We conducted a retrospective observational cohort study in six pediatric intensive care units (PICUs) across Canada. Read More

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Tissue Damage, Not Infection, Triggers Hepatic Unfolded Protein Response in an Experimental Rat Peritonitis Model.

Front Med (Lausanne) 2022 16;9:785285. Epub 2022 Mar 16.

Department of Biomedical Sciences, Institute for Medical Biochemistry, University of Veterinary Medicine Vienna, Vienna, Austria.

Background: Abdominal surgery is an efficient treatment of intra-abdominal sepsis. Surgical trauma and peritoneal infection lead to the activation of multiple pathological pathways. The liver is particularly susceptible to injury under septic conditions. Read More

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Total gastrectomy due to emphysematous and necrotizing gastritis associated with Sarcina ventriculi in an 18-year-old patient.

Rev Esp Enferm Dig 2022 Apr 1. Epub 2022 Apr 1.

Anatomía Patológica, Hospital Universitario de Navarra.

An 18-year-old woman with no pathological history, admitted to Emergency Department with abdominal pain and vomiting after consuming alcohol and cannabis in the last 36 hours. On physical examination, she presented with abdominal distention, signs of peritoneal irritation and sepsis. Abdominal computed tomography showed gastric, esophageal and duodenal distension, gastric and portal pneumatosis and the presence of free intra-abdominal fluid. Read More

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Difference between delayed anastomosis and early anastomosis in damage control laparotomy affecting the infusion volume and NPWT output volume: is infusion restriction necessary in delayed anastomosis? A single-center retrospective analysis.

Trauma Surg Acute Care Open 2022 8;7(1):e000860. Epub 2022 Mar 8.

Department of Surgery, Iwate Medical University, School of Medicine, Iwate, Japan.

Objectives: During temporary abdominal closure (TAC) with damage control laparotomy (DCL), infusion volume and negative-pressure wound therapy (NPWT) output volume are associated with the success and prognosis of primary fascial closure. The same may also hold true for anastomosis. The aim of this research is to evaluate whether the difference between early anastomosis and delayed anastomosis in DCL is related to infusion volume and NPWT output volume. Read More

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Portal Vein Thrombosis and Pyogenic Liver Abscess With Concomitant Bacteremia in a Patient With COVID-19 Infection: A Case Report and Brief Review.

J Investig Med High Impact Case Rep 2022 Jan-Dec;10:23247096221084513

Mountain View Medical Center, Las Vegas, NV, USA.

The 2019 coronavirus disease (COVID-19) can present with a wide variety of clinical manifestations, including a hypercoagulable state leading to both arterial and venous thrombosis. Portal vein thrombosis (PVT) in the setting of COVID-19 has rarely been reported in the medical literature. Pylephlebitis with concomitant liver abscess is a rare complication of intra-abdominal infection. Read More

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Risk Factors for Mortality in Abdominal Infection Patients in ICU: A Retrospective Study From 2011 to 2018.

Front Med (Lausanne) 2022 25;9:839284. Epub 2022 Feb 25.

Department of Critical Care Medicine, Nanfang Hospital, The First School of Clinical Medicine, Southern Medical University, Guangzhou, China.

To identify the risk factors related to the patient's 28-day mortality, we retrospectively reviewed the records of patients with intra-abdominal infections admitted to the ICU of Nanfang Hospital, Southern Medical University from 2011 to 2018. Multivariate Cox proportional hazard regression analysis was used to identify independent risk factors for mortality. Four hundred and thirty-one patients with intra-abdominal infections were analyzed in the study. Read More

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February 2022

Abdominal Sepsis - Current Definitions and Practice.

Chirurgia (Bucur) 2021 Dec;116(6 Suppl):S16-S27

Abdominal sepsis remains the second most common source of sepsis, a life-threatening condition that became a global health priority in the medical field research. Open abdomen is part of the damage control surgery, a life-saving strategy in a well-selected group of surgical patients with severe abdominal sepsis and intra-abdominal hypertension. Definitions and recommendations in the management of abdominal sepsis and open abdomen have gradually evolved, as a reflection of the progress of both the comprehension of physiopathological mechanisms involved in sepsis and the technology of different temporary abdominal closure systems. Read More

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December 2021