Am J Surg Pathol 2021 Jan 13. Epub 2021 Jan 13.
Department of Pathology Clinical Research Center, Incheon St. Mary's Hospital Department of Pathology, Eunpyeong St. Mary's Hospital, College of Medicine, The Catholic University of Korea Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD.
The tumor microenvironment (TME) has become an important area of investigation with respect to improving prognosis in malignancies. Here we evaluated TME prognostic risk in small intestinal adenocarcinomas based on histologic assessment of tumor budding at the peritumoral-invasive front (pTB) and stromal tumor-infiltrating lymphocytes (sTILs). pTB and sTILs were analyzed in 230 surgically resected small intestinal adenocarcinomas, as recommended by the International Tumor Budding Consensus Conference (ITBCC) and the International TILs Working Group (ITWG). Read More