2,144 results match your criteria Intestinal Stromal Tumors


[Expression of ARID1A in ovarian seromucinous neoplasms and its clinicopathological significance].

Zhonghua Bing Li Xue Za Zhi 2020 Jun;49(6):588-593

Department of Pathology, the First Medical Center of PLA General Hospital, Beijing 100853, China.

To investigate the clinical, pathological and immunohistochemical features of seromucinous neoplasms, including seromucinous cystadenoma, borderline tumour and seromucinous carcinomas of the ovary. A retrospective review of the seromucinous neoplasms collected between June 2006 and December 2018 was conducted at the First Medical Center of PLA General Hospital. EnVision immunohistochemical staining was used to detect the expression of CK7, PAX8, ER, PR, WT1, p16, p53 and Baf250a which was encoded by the ARID1A gene. Read More

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http://dx.doi.org/10.3760/cma.j.cn112151-20200224-00130DOI Listing

[Borderline ovarian tumours: CNGOF Guidelines for clinical practice - Biopathology of Ovarian borderline tumors].

Gynecol Obstet Fertil Senol 2020 May 15. Epub 2020 May 15.

Institut de Pathologie multi-sites des HOSPICES CIVILS DE LYON, Centre Hospitalier Lyon Sud, Centre de biologie et pathologie Sud, 165 Chemin du Grand revoyet, 69495 Pierre Bénite, France; Société Française de Gynéco Pathologie, France. Electronic address:

Objectives: Ovarian borderline tumors (OBT) represent a heterogeneous group of lesions with specific management for each histological sub-type. Thus, the correct histological diagnosis is mandatory.

Material And Methods: References were searched by PubMed from january 2000 to january 2018 and original articles in French and English literature were selected. Read More

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http://dx.doi.org/10.1016/j.gofs.2020.05.007DOI Listing

Retroperitoneal fibromatosis presenting as a mesenteric mass: A case report.

Medicine (Baltimore) 2020 Apr;99(17):e18799

Department of Hematology, Chinese Academy of Medical Sciences and Peking Union Medical College Hospital, Beijing.

Rationale: Fibromatoses or desmoid tumors are relatively rare tumors derived from the musculoaponeurotic system. This tumor has no specific clinical symptoms and it is sometimes misdiagnosed as other diseases such as gastrointestinal stromal tumors (GISTs).

Patient Concerns: A 28-year-old man visited Peking Union Medical College for a tangible abdominal mass without abdominal pain or distention. Read More

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http://dx.doi.org/10.1097/MD.0000000000018799DOI Listing

Gallbladder GIST: A review of literature.

Authors:
Ashish Gupta

Pol Przegl Chir 2019 Nov;92(1):34-37

Department of Surgery, All India Institute of Medical Sciences, Rishikesh, India.

Mesenchymal tumors of the gallbladder are rarely encountered in clinical practice. The Gastrointestinal Stromal Tumor (GIST) of the gallbladder is rarely encountered. These tumors most commonly arise from the interstitial cells of Cajal (ICC), the pacemakers of the intestinal system. Read More

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http://dx.doi.org/10.5604/01.3001.0013.5550DOI Listing
November 2019

[A rare case of cystadenoma in the small intestine].

Beijing Da Xue Xue Bao Yi Xue Ban 2020 Apr;52(2):382-384

Department of Oncology, Hebei Hosptical of Traditional Chinese Medicine Affiliated to Hebei University of Traditional Chinese Medicine, Shijiazhuang 050011, China.

In recent years, there have been more and more reports about cystadenoma. Cystadenoma can occur in many parts of the body, and cystadenoma in different parts may show different clinical symptoms, however, some patients with cystadenoma have no symptoms. The vast majority of cystadenomas are benign lesions, but a small number of cystadenomas can be malignant. Read More

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[Clinical evaluation of tumor-stroma ratio in pseudomyxoma peritonei from the appendix].

Beijing Da Xue Xue Bao Yi Xue Ban 2020 Apr;52(2):240-246

Department of Peritoneal Cancer Surgery, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China.

Objective: To evaluate the effect of tumor-stroma ratio (TSR) on disease progression and prognosis of pseudomyxoma peritonei (PMP) from the appendix.

Methods: The study included 30 PMP patients with complete individual patient data, who underwent cytoreductive surgery (CRS) plus hyperthermic intraperitoneal chemotherapy (HIPEC) in Beijing Shijitan Hospital. Image-Pro Plus was used to quantitatively analyze the proportion of tumor and stromal areas in hematoxylin-eosin staining pathological images, from which TSR was derived. Read More

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A case of a diverticulum-like giant jejunal gastrointestinal stromal tumour presenting with intraperitoneal peritonitis due to rupture.

Int J Surg Case Rep 2020 1;69:68-71. Epub 2020 Apr 1.

Department of Pathology Clinical Laboratory, Hiroshima Prefectural Hospital, Hiroshima, Japan.

Introduction: Early diagnosis of small intestinal gastrointestinal stromal tumours (GISTs) is difficult. These tumours often present with peritonitis and intraperitoneal bleeding due to rupture. We experienced a case of a tumor that grows to 12 cm asymptomatic. Read More

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http://dx.doi.org/10.1016/j.ijscr.2020.03.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7154945PMC

[Acute complications of gastrointestinal stromal tumors].

Khirurgiia (Mosk) 2020 (3):67-73

Chita State Medical Academy of the Ministry of Health of Russia, Chita, Russia.

Objective: To analyze acute complications of stromal gastrointestinal tumors and determine diagnosis and optimal treatment of these patients.

Material And Methods: There were 33 patients with acute complications of GIST aged 40-74 years.

Results: Acute complications were presented by gastrointestinal and (or) intratumoral (interstitial) bleeding (n=31). Read More

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http://dx.doi.org/10.17116/hirurgia202003167DOI Listing

Comprehensive routine diagnostic screening to identify predictive mutations, gene amplifications, and microsatellite instability in FFPE tumor material.

BMC Cancer 2020 Apr 7;20(1):291. Epub 2020 Apr 7.

Department of Pathology, Radboud university medical center, PO Box 9101, 6500, HB, Nijmegen, the Netherlands.

Background: Sensitive and reliable molecular diagnostics is needed to guide therapeutic decisions for cancer patients. Although less material becomes available for testing, genetic markers are rapidly expanding. Simultaneous detection of predictive markers, including mutations, gene amplifications and MSI, will save valuable material, time and costs. Read More

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http://dx.doi.org/10.1186/s12885-020-06785-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7137451PMC

Difference of computed tomographic characteristic findings between gastric and intestinal gastrointestinal stromal tumors.

Jpn J Radiol 2020 Apr 4. Epub 2020 Apr 4.

Department of Radiology, Shiga University of Medical Science, Seta, Tsukinowa-cho, Otsu, Shiga, 520-2192, Japan.

Purpose: We aimed to compare the computed tomography (CT) imaging differences between gastric and intestinal gastrointestinal stromal tumors (GISTs).

Materials And Methods: Thirty-eight patients with 38 gastric GISTs and 27 with 31 intestinal GISTs were enrolled. Tumors were classified as small (< 5 cm) or large (≥ 5 cm). Read More

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http://dx.doi.org/10.1007/s11604-020-00962-0DOI Listing

Model-Based Biomarker Selection for Dose Individualization of Tyrosine-Kinase Inhibitors.

Front Pharmacol 2020 12;11:316. Epub 2020 Mar 12.

Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden.

Tyrosine-kinase inhibitors (TKIs) demonstrate high inter-individual variability with respect to safety and efficacy and would therefore benefit from dose or schedule adjustments. This study investigated the efficacy, safety, and economical aspects of alternative dosing options for sunitinib in gastro-intestinal stromal tumors (GIST) and axitinib in metastatic renal cell carcinoma (mRCC). Dose individualization based on drug concentration, adverse effects, and sVEGFR-3 was explored using a modeling framework connecting pharmacokinetic and pharmacodynamic models, as well as overall survival. Read More

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http://dx.doi.org/10.3389/fphar.2020.00316DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7080977PMC

[Rectal Gastrointestinal Stromal Tumor(GIST)Excised by Two Teams Following Neoadjuvant Chemotherapy-A Case Report].

Gan To Kagaku Ryoho 2019 Dec;46(13):2580-2582

Dept. of Gastrointestinal and Pediatric Surgery, Tokyo Medical University.

A 67-year-old man presented with bloody stools. Colonoscopy showed a small submucosal tumor in the lower rectum. As the tumor was small, follow-up was chosen. Read More

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December 2019

[A Case of Omental Desmoid Tumor after a Small Bowel Resection for Gastrointestinal Stromal Tumor].

Gan To Kagaku Ryoho 2019 Dec;46(13):2488-2490

Dept. of Surgery, Osaka General Hospital of West Japan Railway Company.

An intra-abdominaldesmoid tumor, especially omentaldesmoid tumor, is rare. Here, we report a case of omentaldesmoid tumor after a smallbowelresection for gastrointestinalstromaltumor (GIST). A 73-year-old man underwent a partial resection of smallbowelfor GIST. Read More

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December 2019

[A Case of Peritoneal Metastasis Resection from GIST of the Small Intestine with Focal Resistance Against Imatinib Mesylate].

Gan To Kagaku Ryoho 2019 Dec;46(13):2452-2454

Dept. of Surgery, Tohoku University Graduate School of Medicine.

A 69-year-old man was referred to our institute for the surgical resection of focal resistant peritoneal GIST during imatinib administration. He had been diagnosed with GIST of the small intestine with liver and peritoneal metastases, and imatinib treatment was initiated. Shortly after imatinib administration, the primary lesion perforated, and thus, partial resection of the small intestine was performed. Read More

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December 2019

[A Case of Gastrointestinal Stromal Tumor in the Rectum with Preservation of Anal Function after Neoadjuvant Chemotherapy UsingImatinib].

Gan To Kagaku Ryoho 2019 Dec;46(13):2383-2385

Dept. of Surgery, Kishiwada Tokushukai Hospital.

A n 81-year-old woman was admitted to our institution. Computed tomography performed before transcatheter aortic valve implantation(TAVI)for aortic stenosis revealed a tumor in the rectum. Lower endoscopy revealed that the tumor was a 60mm submucosal tumor and located 2 cm from the anal verge. Read More

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December 2019

[A Case Report of Gastrointestinal Bleeding with Difficulty in Diagnosis].

Gan To Kagaku Ryoho 2019 Dec;46(13):2134-2136

Dept. of Surgery, Saiseikai Yahata General Hospital.

The authors report a case involving a 55-year-old female patient who presented with melena and anemia 8 years ago. Esophagogastroduodenoscopy, colonoscopy, and CT did not reveal any sign of lesions except multiple uterine myoma. On reevaluation after the onset of melena, we did not find any lesions. Read More

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December 2019

Incidence and time trends of sarcoma (2000-2013): results from the French network of cancer registries (FRANCIM).

BMC Cancer 2020 Mar 6;20(1):190. Epub 2020 Mar 6.

French Network of Cancer Registries, F-31000, Toulouse, France.

Background: The exhaustive collection of new sarcoma cases and their second histologic review offer a unique opportunity to study their incidence and time trends in France according to the major subtypes.

Methods: Data were collected from population-based cancer registries covering 22% of the French population. Crude and world age-standardized incidence rates (ASR) were estimated according to anatomic, histological and genetic groups, age and sex over the 2010-2013 period. Read More

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http://dx.doi.org/10.1186/s12885-020-6683-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7059296PMC

Quantitative, qualitative and spatial analysis of lymphocyte infiltration in periampullary and pancreatic adenocarcinoma.

Int J Cancer 2020 Jun 20;146(12):3461-3473. Epub 2020 Mar 20.

Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.

Immunotherapeutic modalities are currently revolutionizing cancer treatment. In pancreatic cancer, however, early clinical trials have been disappointing. The optimization of immunotherapeutic strategies requires better understanding of the inflammatory tumor microenvironment. Read More

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http://dx.doi.org/10.1002/ijc.32945DOI Listing

Cell-type-specific signaling networks in heterocellular organoids.

Nat Methods 2020 03 17;17(3):335-342. Epub 2020 Feb 17.

Cell Communication Lab, Department of Oncology, University College London Cancer Institute, London, UK.

Despite the widespread adoption of organoids as biomimetic tissue models, methods to comprehensively analyze cell-type-specific post-translational modification (PTM) signaling networks in organoids are absent. Here, we report multivariate single-cell analysis of such networks in organoids and organoid cocultures. Simultaneous analysis by mass cytometry of 28 PTMs in >1 million single cells derived from small intestinal organoids reveals cell-type- and cell-state-specific signaling networks in stem, Paneth, enteroendocrine, tuft and goblet cells, as well as enterocytes. Read More

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http://dx.doi.org/10.1038/s41592-020-0737-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7060080PMC
March 2020
32.072 Impact Factor

The Intestinal Tumour Microenvironment.

Adv Exp Med Biol 2020 ;1226:1-22

Department of Microbiology and Immunology, University of Otago, Dunedin, New Zealand.

The tumour microenvironment (TME) of intestinal tumours is highly complex and comprises a network of stromal cells, tumour cells, immune cells and fibroblasts, as well as microorganisms. The tumour location, environmental factors and the tumour cells themselves influence the cells within the TME. Immune cells can destroy tumour cells and are associated with better patient prognosis and response to therapy; however, immune cells are highly plastic and easily influenced to instead promote tumour growth. Read More

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http://dx.doi.org/10.1007/978-3-030-36214-0_1DOI Listing
February 2020

Antiangiogenic immunotherapy suppresses desmoplastic and chemoresistant intestinal tumors in mice.

J Clin Invest 2020 Mar;130(3):1199-1216

Department of Oncology, University of Lausanne and CHUV, Epalinges, Switzerland.

Mutations in APC promote colorectal cancer (CRC) progression through uncontrolled WNT signaling. Patients with desmoplastic CRC have a significantly worse prognosis and do not benefit from chemotherapy, but the mechanisms underlying the differential responses of APC-mutant CRCs to chemotherapy are not well understood. We report that expression of the transcription factor prospero homeobox 1 (PROX1) was reduced in desmoplastic APC-mutant human CRCs. Read More

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http://dx.doi.org/10.1172/JCI129558DOI Listing

Benign and non-neoplastic tumours of the duodenum.

Prz Gastroenterol 2019 20;14(4):233-241. Epub 2019 Dec 20.

Department of Internal Medicine, Angiology and Physical Medicine, Center for Laser Diagnostics and Therapy in Bytom, Medical University of Silesia in Katowice, Poland.

This review study describes the problem of duodenal tumours, which are rare but important in gastrological practice. The most common location of small intestinal tumours is the duodenum, and this observation is probably partly due to the greater diagnostic availability for most proximal segments of the small intestine. Among tumours the following should be mentioned - benign: adenomas, lipomas, haemangiomas, and leiomyomas; and malignant: malignant tumours of epithelial origin, primary gastrointestinal stromal tumours, neuroendocrine tumours and carcinoids, lymphomas, sarcomas, teratomas, and secondary metastases. Read More

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http://dx.doi.org/10.5114/pg.2019.90250DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6983766PMC
December 2019

A Huge Pelvic-Abdominal Malignant GIST Tumour in a Patient with Neurofibromatosis Type 1: Case Report and Literature Review.

Case Rep Oncol Med 2020 4;2020:6590307. Epub 2020 Jan 4.

Oncology Center, King Hamad University Hospital, Bahrain.

Gastrointestinal stromal tumours are rare tumours of the gastrointestinal tract (GIT) accounting for 0.1%-3% of all gastrointestinal tumours. The most common location is the stomach (55%) followed by the small bowel (31. Read More

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http://dx.doi.org/10.1155/2020/6590307DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6964723PMC
January 2020

Use of omental patch and endoscopic closure technique as an alternative to surgery after endoscopic full thickness resection of gastric intestinal stromal tumors: A series of cases.

World J Clin Cases 2020 Jan;8(1):120-125

Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, United States.

Background: Gastrointestinal stromal tumors (GISTs) originate from interstitial cells of . GISTs can occur anywhere along the gastrointestinal tract. Large lesions have traditionally been removed surgically. Read More

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http://dx.doi.org/10.12998/wjcc.v8.i1.120DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6962076PMC
January 2020

[Gastrointestinal glomus tumors: a clinicopathological analysis of fifteen cases].

Zhonghua Bing Li Xue Za Zhi 2020 Jan;49(1):22-27

Department of Pathology, the First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, China.

To investigate the clinicopathological features, diagnosis and differential diagnosis of gastrointestinal glomus tumors (GIGT). Totally 15 cases of GIGT were collected at the First Affiliated Hospital, Zhengzhou University, from January 2011 to June 2018. The clinicopathological features, immunophenotype, BRAF V600E mutation and prognosis were retrospectively analyzed. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0529-5807.2020.01.005DOI Listing
January 2020

Primary gastrointestinal liposarcoma-a clinicopathological study of 8 cases of a rare entity.

Hum Pathol 2020 Mar 26;97:80-93. Epub 2019 Dec 26.

Department of Pathology and Laboratory Medicine, University of Miami, Miami, FL. Electronic address:

Primary gastrointestinal liposarcoma is rare, and information regarding this entity is largely based on single case studies. We report on 8 patients with primary liposarcoma of the gastrointestinal tract and review the pertinent literature. The cohort includes 6 men and 2 women who ranged in age from 51 to 81 years (median 68. Read More

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http://dx.doi.org/10.1016/j.humpath.2019.12.004DOI Listing

Long-Term Survival After Multidisciplinary Treatment Including Surgery for Metachronous Metastases of Small Intestinal Gastrointestinal Stromal Tumors after Curative Resection: A Case Report.

Am J Case Rep 2019 Dec 26;20:1942-1948. Epub 2019 Dec 26.

Department of Digestive and Transplantation Surgery, Tokyo Medical University Hachioji Medical Center, Tokyo, Japan.

BACKGROUND Currently, 3 molecular targeted drugs are available for the treatment of unresectable and recurrent gastrointestinal stromal tumors (GISTs), and result in improved prognoses and rare occurrence of bone metastases. However, there is no established treatment guideline for bone metastases of GIST. CASE REPORT The patient was a 56-year-old male who was diagnosed with leiomyosarcoma in 1997. Read More

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http://dx.doi.org/10.12659/AJCR.918606DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6944036PMC
December 2019

Calcium-activated chloride channel regulator 1 (CLCA1): More than a regulator of chloride transport and mucus production.

World Allergy Organ J 2019 Nov 29;12(11):100077. Epub 2019 Nov 29.

Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450000, China.

CLCA1 is a member of the CLCA (calcium-activated chloride channel regulator) family and plays an essential role in goblet cell mucus production from the respiratory tract epithelium. CLCA1 also regulates Ca-dependent Cl transport that involves the channel protein transmembrane protein 16A (TMEM16A) and its accessary molecules. CLCA1 modulates epithelial cell chloride current and participates in the pathogenesis of mucus hypersecretory-associated respiratory and gastrointestinal diseases, including asthma, chronic obstructive pulmonary disease, cystic fibrosis, pneumonia, colon colitis, cystic fibrosis intestinal mucous disease, ulcerative colitis, and gastrointestinal parasitic infection. Read More

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http://dx.doi.org/10.1016/j.waojou.2019.100077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6909348PMC
November 2019

Endometriosis-related pathology: a discussion of selected uncommon benign, premalignant and malignant lesions.

Histopathology 2020 Jan;76(1):76-92

Department of Pathology, Belfast Health and Social Care Trust, Belfast, UK.

Endometriosis is an extremely common condition and, in most cases, establishing a histological diagnosis is straightforward, although a variety of benign alterations may result in problems with interpretation. In this review, I discuss selected uncommon variants of endometriosis or benign alterations that may result in diagnostic problems. The topics covered include the contentious issue of so-called atypical endometriosis, stromal endometriosis, polypoid endometriosis, and the association of endometriosis with florid mesothelial hyperplasia. Read More

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http://dx.doi.org/10.1111/his.13970DOI Listing
January 2020

[A case of liver metastasis 11 years after resection of a gastrointestinal stromal tumor of the duodenum].

Nihon Shokakibyo Gakkai Zasshi 2019 ;116(12):1030-1038

Department of Gastroenterology, Hiroshima Red Cross Hospital and Atomic-bomb Survivors Hospital.

A 77-year-old Japanese man with a gastrointestinal stromal tumor (GIST) had undergone a duodenectomy 11 years prior. At that time, he had an incidentally detected left renal cell carcinoma, for which he underwent a nephrectomy and was followed-up at our institution. Twenty-four months after the nephrectomy, a 13-mm low-density mass was found on abdominal computed tomography (CT). Read More

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http://dx.doi.org/10.11405/nisshoshi.116.1030DOI Listing
December 2019

Ovarian Sertoli-Leydig cell tumour with α-fetoprotein-producing intestinal glandular cells. Clinical case and short review of basic literature.

Pol J Pathol 2019 ;70(3):226-231

Department of Pathomorphology, Jagiellonian University Medical College, Krakow, Poland.

Sertoli Leydig cell tumor of the ovary, is a rare neoplasm from the group of sex cord-stromal tumors of the ovary, accounting for less than 1% of all ovarian tumors. Among the Sertoli Leydig cell tumors, we distinguish a separate group of tumors secreting α-fetoprotein (AFP). The young 24-year-old woman presented to the Clinical Department of Gynaecological Endocrinology at the University Hospital in Krakow due to secondary amenorrhea, hirsutism and worsening abdominal pain for several months. Read More

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http://dx.doi.org/10.5114/pjp.2019.90402DOI Listing
January 2020

Case report of ascending colon cancer and multiple jejunal GISTs in a patient with neurofibromatosis type 1 (NF1).

BMC Cancer 2019 Dec 5;19(1):1196. Epub 2019 Dec 5.

Department of Gastroenterological Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, China.

Background: NF1(Neurofibromatosis type 1) is an autosomal dominant genetic disorder. Patients with NF1 have an increased risk of developing benign or malignant tumours, such as gastrointestinal stromal tumours (GISTs). However, the coexistence of NF1, GIST and colon cancer is very rare, and few cases have been reported in the literature. Read More

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http://dx.doi.org/10.1186/s12885-019-6375-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6896298PMC
December 2019

Huge Gastrointestinal Stromal Tumor of the Jejunum Presenting as Bowel Obstruction: A Rare Presentation.

Gastrointest Tumors 2019 Oct 20;6(3-4):116-121. Epub 2019 Aug 20.

Department of General Surgery, All India Institute of Medical Sciences, Bhopal, India.

Gastrointestinal stromal tumors (GISTs) are mesenchymal tumors of the gastrointestinal tract arising from interstitial Cajal cells. A 54-year-old male patient without any comorbidities presented to the emergency department with complaints of abdominal distension, inability to pass flatus, and no motion for the past 2 days. Abdominal X-ray showed multiple air-fluid levels suggesting bowel obstruction. Read More

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http://dx.doi.org/10.1159/000501744DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6872987PMC
October 2019

Development and validation of LC-MS/MS method for imatinib and norimatinib monitoring by finger-prick DBS in gastrointestinal stromal tumor patients.

PLoS One 2019 19;14(11):e0225225. Epub 2019 Nov 19.

Experimental and Clinical Pharmacology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy.

The introduction of imatinib, an oral tyrosine kinase inhibitor, as first-line standard therapy in patients with unresectable, metastatic, or recurrent gastro-intestinal stromal tumor (GIST), strongly improved their treatment outcomes. However, therapeutic drug monitoring (TDM) is recommended for this drug due to the large inter-individual variability in plasma concentration when standard dose is administered. A Cmin higher than 760 ng/mL was associated with a longer progression free survival. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0225225PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6863526PMC

Adding trans-abdominal elastography to the diagnostic tool for an ileal gastrointestinal stromal tumor: a case report.

BMC Med Imaging 2019 11 15;19(1):88. Epub 2019 Nov 15.

Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University, No.7, Chung-Shan South Road, Taipei, 100, Taiwan.

Background: Diagnosis of gastrointestinal stromal tumors (GISTs) in the distal small intestine is difficult by endoscopic ultrasound. This is the first reported case of an ileal GIST, which is diagnosed by transabdominal sonography and strain elastography.

Case Presentation: A 75 y/o woman presented with tarry stool and dizziness. Read More

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http://dx.doi.org/10.1186/s12880-019-0385-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6858690PMC
November 2019

Case of Irreducible Ileocecal Intussusception Due to Leiomyoma of the Colon.

Cureus 2019 Sep 6;11(9):e5583. Epub 2019 Sep 6.

General Surgery / Bariatric Surgery, Hackensack Meridian Health Mountainside Medical Center, Montclair, USA.

Intussusception is defined as the telescoping of the proximal segment of the bowel into the distal segment. In most clinical cases, pediatric intussusception is much more common than adult intussusception. Pediatric intussusception is often due to viral or bacterial infections, which lead to the inflammation of lymphoid tissue in the intestine. Read More

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http://dx.doi.org/10.7759/cureus.5583DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6820895PMC
September 2019
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Targeting Regorafenib-Induced Toxicity through Inhibition of Gut Microbial β-Glucuronidases.

ACS Chem Biol 2019 12 12;14(12):2737-2744. Epub 2019 Nov 12.

Department of Chemistry , University of North Carolina at Chapel Hill , Chapel Hill , North Carolina 27599 , United States.

Regorafenib (Stivarga) is an oral small molecule kinase inhibitor used to treat metastatic colorectal cancer, hepatocellular carcinomas, and gastrointestinal stromal tumors. Diarrhea is one of the most frequently observed adverse reactions associated with regorafenib. This toxicity may arise from the reactivation of the inactive regorafenib-glucuronide to regorafenib by gut microbial β-glucuronidase (GUS) enzymes in the gastrointestinal tract. Read More

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http://dx.doi.org/10.1021/acschembio.9b00663DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7254866PMC
December 2019
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Sarcomatoid Renal Cell Carcinoma With Unusual Metastasis to the Small Intestine Manifesting as Perforated Appendicitis.

In Vivo 2019 Nov-Dec;33(6):2225-2228

Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY, U.S.A.

Background: Sarcomatoid renal cell carcinoma is a rare form of dedifferentiated carcinoma with a high metastatic rate and adverse prognosis. Common sites of metastasis include lymph nodes, lung, liver and bone. We report a case of sarcomatoid renal cell carcinoma with unusual metastasis to the small intestine in a 65-year-old female with a history of clear-cell renal cell carcinoma with focal sarcomatoid transformation. Read More

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http://dx.doi.org/10.21873/invivo.11726DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6899143PMC

Ovarian tumors: a survey of selected advances of note during the life of this journal.

Authors:
Robert H Young

Hum Pathol 2020 Jan 22;95:169-206. Epub 2019 Oct 22.

The James Homer Wright Pathology Laboratories, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. Electronic address:

The author reviews highlights of advances in knowledge concerning ovarian tumor pathology since the time of an essay in the first issue of this Journal written by Dr Robert E. Scully, who, both before and for several decades after the Journal was instituted, made many original contributions to the field and was the major architect of the 1973 World Health Organization classification of ovarian tumors which was much more clear and logical than prior ones. The current review considers the neoplasms in essentially the same order as was done in the first issue of this journal and presents a personal look at the highlights of new information concerning various well-known categories, surface epithelial, germ cell, sex cord-stromal, metastatic neoplasms and briefly, benign so-called tumor-like lesions. Read More

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http://dx.doi.org/10.1016/j.humpath.2019.09.002DOI Listing
January 2020
2 Reads

Primary Gastrointestinal Stromal Tumor Mimicking as Gynecologic Mass: Characteristics, Management, and Prognosis.

J Surg Res 2020 02 22;246:584-590. Epub 2019 Oct 22.

Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address:

Background: Primary gastrointestinal stromal tumor (GIST)-mimicking gynecologic masses are easily misdiagnosed. This study aimed to investigate the clinicopathological features, management, and prognosis of primary GIST mimicking as gynecologic mass.

Methods: Clinicopathological and survival data of GIST mimicking as gynecologic mass admitted to our center from January 2005 to December 2017 were retrospectively analyzed. Read More

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http://dx.doi.org/10.1016/j.jss.2019.09.043DOI Listing
February 2020
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Comprehensive Assessment of GPR68 Expression in Normal and Neoplastic Human Tissues Using a Novel Rabbit Monoclonal Antibody.

Int J Mol Sci 2019 Oct 23;20(21). Epub 2019 Oct 23.

Institute of Pharmacology and Toxicology, Jena University Hospital, D-07747 Jena, Germany.

GPR68 (OGR1) belongs to the proton-sensing G protein-coupled receptors that are involved in cellular adaptations to pH changes during tumour development. Although expression of GPR68 has been described in many tumour cell lines, little is known about its presence in human tumour entities. We characterised the novel rabbit monoclonal anti-human GPR68 antibody 16H23L16 using various cell lines and tissue specimens. Read More

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http://dx.doi.org/10.3390/ijms20215261DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6862545PMC
October 2019
1 Read
2.862 Impact Factor

Unicentric Castleman disease, hyaline vascular variant, stromal rich, with increased plasma cells and a high level of serum IL-6: Raising the diagnostic and therapeutic issues.

Ann Diagn Pathol 2019 Dec 3;43:151398. Epub 2019 Aug 3.

Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States. Electronic address:

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http://dx.doi.org/10.1016/j.anndiagpath.2019.08.002DOI Listing
December 2019
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Successful Curative Cryoablation of an Esophageal Gastrointestinal Stromal Tumor.

ACG Case Rep J 2019 Jun 12;6(6):e00076. Epub 2019 Jun 12.

Division of Gastroenterology and Hepatology, University of California, Irvine Medical Center, Orange, CA.

Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract. The most common location of GIST is the stomach; however, occurrences of GIST in the esophagus are also possible albeit rare. Although the current standard of care for gastric and intestinal GIST involves surgery and tyrosine kinase inhibitors, this case report focuses on the potential of treating esophageal GIST through a novel means of cryoablation therapy. Read More

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http://dx.doi.org/10.14309/crj.0000000000000076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6722331PMC
June 2019
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Primary Jejunal Gastrointestinal Stromal Tumor: Diagnosis Delay of 3 Years but Successful Management in Early Stage (II) by Surgery and Adjuvant Therapy.

Gastrointest Tumors 2019 Aug 3;6(1-2):36-42. Epub 2019 Apr 3.

Department of Oncology, Bangladesh Specialized Hospitals, Dhaka, Bangladesh.

In the digestive system, mesenchymal origin of tumors is quite rare; in general, they are recognized as gastrointestinal stromal tumors (GISTs). The incidence of GISTs is very low (2 in 100,000), while jejunal GISTs are extremely rare, accounting for 0.1-3% of all gastrointestinal (GI) tumors. Read More

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http://dx.doi.org/10.1159/000496973DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6738160PMC
August 2019
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Prognostic Significance of Stromal and Intraepithelial Tumor-Infiltrating Lymphocytes in Small Intestinal Adenocarcinoma.

Am J Clin Pathol 2020 01;153(1):105-118

Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.

Objectives: Assessment of tumor-infiltrating lymphocytes (TILs) may predict the prognosis and therapeutic benefit of immunotherapy in small intestinal adenocarcinoma (SIAC) patients.

Methods: TILs were evaluated in 231 surgically resected SIACs and compared with microsatellite instability (MSI) and clinicopathologic variables. The average number of intraepithelial TILs (iTILs) and the average density of stromal TILs (sTILs) were calculated separately. Read More

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http://dx.doi.org/10.1093/ajcp/aqz136DOI Listing
January 2020
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Exploiting differential Wnt target gene expression to generate a molecular biomarker for colorectal cancer stratification.

Gut 2020 Jun 28;69(6):1092-1103. Epub 2019 Sep 28.

Intestinal Stem Cell Biology Lab, Wellcome Trust Centre Human Genetics, University of Oxford, Oxford, UK

Objective: Pathological Wnt pathway activation is a conserved hallmark of colorectal cancer. Wnt-activating mutations can be divided into: i) ligand-independent (LI) alterations in intracellular signal transduction proteins (, β-catenin), causing constitutive pathway activation and ii) ligand-dependent (LD) mutations affecting the synergistic R-Spondin axis (, -fusions) acting through amplification of endogenous Wnt signal transmembrane transduction. Our aim was to exploit differential Wnt target gene expression to generate a mutation-agnostic biomarker for LD tumours. Read More

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http://dx.doi.org/10.1136/gutjnl-2019-319126DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212029PMC
June 2020
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Proportion of goblet cell is associated with malignant potential in invasive mucinous adenocarcinoma of the lung.

Pathol Int 2019 Sep;69(9):526-535

Division of Pathology, Exploratory Oncology Research & Clinical Trial Center, National Cancer Center Hospital East, Kashiwa, Japan.

Invasive mucinous adenocarcinoma (IMA) is a newly classified variant of lung adenocarcinoma. The aim of this study was to examine the correlation between the proportion of goblet cells and the clinicopathological characteristics of IMA. Ninety-nine patients with stage I IMA were included in this study. Read More

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http://dx.doi.org/10.1111/pin.12853DOI Listing
September 2019

[Advances in radiological studies of gastrointestinal stromal tumors].

Authors:
J Z Li L Tang

Zhonghua Wei Chang Wai Ke Za Zhi 2019 Sep;22(9):891-895

Department of Radiology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital & Institute, Beijing 100142, China.

The commonly used radiological examinations for gastrointestinal stromal tumor (GIST) include ultrasound, CT, magnetic resonance imaging and PET, which play important roles in the individualized treatment of GIST through the assistance of the detection, location, diagnose and differential diagnosis, biological behavior and risk evaluation, operation planning, therapeutic effects prediction and follow-up. Standardized predisposal, multi-planar reconstruction and multi-phase enhancement are of great significance in the detection of small GIST lesions. Differences in drainage vessels and enhancement characteristics of tumors are helpful in differentiating small intestinal GIST from pancreatic cancer, neuroendocrine tumors and other abdominal non-GIST tumors. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1671-0274.2019.09.015DOI Listing
September 2019
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