2,000 results match your criteria Intestinal Stromal Tumors


Clinical implications of the oncometabolite succinate in SDHx-mutation carriers.

Clin Genet 2019 Apr 12. Epub 2019 Apr 12.

Department of Endocrinology and Metabolic Diseases, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Succinate dehydrogenase (SDH) mutations lead to the accumulation of succinate, which acts as an oncometabolite. Germline SDHx mutations predispose to paraganglioma (PGL) and pheochromocytoma (PCC), as well as to renal cell carcinoma and gastro-intestinal stromal tumors. The SDHx genes were the first tumor suppressor genes discovered which encode for a mitochondrial enzyme, thereby supporting Otto Warburg's hypothesis in 1926 that a direct link existed between mitochondrial dysfunction and cancer. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/cge.13553
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http://dx.doi.org/10.1111/cge.13553DOI Listing
April 2019
4 Reads

A Consensus Study of the Grading and Typing of Intraductal Papillary Mucinous Neoplasms of the Pancreas.

Pancreas 2019 04;48(4):480-487

The Third Department of Internal Medicine, Division of Gastroenterology and Hepatology, Kansai Medical University, Osaka, Japan.

Objective: The grading and typing of intraductal papillary mucinous neoplasms (IPMNs) of the pancreas are challenging for pathologists. We aimed to clarify the points of consistency and disagreement in assessing the grades and types of IPMNs.

Methods: Digital slide images of 20 IPMNs were independently assessed by 10 Japanese pathologists, who then held a consensus meeting to discuss the points of disagreement and develop a consensus and recommendations. Read More

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http://dx.doi.org/10.1097/MPA.0000000000001270DOI Listing
April 2019
1 Read

Small intestinal perforation due to a huge gastrointestinal stromal tumor in a kidney transplant recipient: a case report and literature review.

BMC Nephrol 2019 Apr 3;20(1):120. Epub 2019 Apr 3.

Department of Urology, Keio University School of Medicine, Tokyo, 160-8582, Japan.

Background: Gastrointestinal stromal tumors (GISTs) in transplant recipients are very rare and only a handful of cases have been reported to date. Here we present the first known case of a huge GIST in a kidney transplant recipient with perforation of small intestine.

Case Presentation: A 64-year-old male presented at our hospital with right colic pain; he had received an ABO incompatible kidney transplant 6 years earlier and was treated with cyclosporine, mycophenolate mofetil, and methylprednisolone. Read More

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http://dx.doi.org/10.1186/s12882-019-1310-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448240PMC
April 2019
3 Reads
1.520 Impact Factor

[Surgical treatment of neurofibromatosis type I followed by retroperitoneal tumor (in Russian only)].

Khirurgiia (Mosk) 2019 (3):5-14

Vishnevsky National Medical Research Center of Surgery, Moscow, Russia.

Aim: To determine the optimal surgical approach in patients with abdominal and retroperitoneal manifestations of Recklinghausen's disease.

Material And Methods: There were 4 patients (3 women and 1 man) with neurofibromatosis type I who were treated at Vishnevsky National Medical Research Center of Surgery.

Results: There were 3 robot-assisted procedures: excision of retroperitoneal tumors (plexiform neurofibroma and schwannoma) in 2 cases and right adrenal pheochromocytoma in 1 patient. Read More

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http://www.mediasphera.ru/issues/khirurgiya-zhurnal-im-n-i-p
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http://dx.doi.org/10.17116/hirurgia20190315DOI Listing
January 2019
2 Reads

Lymphatic endothelium contributes to colorectal cancer growth via the soluble matrisome component GDF11.

Int J Cancer 2019 Mar 19. Epub 2019 Mar 19.

IBD Center, Laboratory of Gastrointestinal Immunopathology, Humanitas Clinical and Research Center, Milan, Italy.

Colorectal cancer (CRC) is one of the most malignant tumors worldwide. Stromal cells residing in the tumor microenvironment strongly contribute to cancer progression through their crosstalk with cancer cells and extracellular matrix. Here we provide the first evidence that CRC-associated lymphatic endothelium displays a distinct matrisome-associated transcriptomic signature, which distinguishes them from healthy intestinal lymphatics. Read More

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http://dx.doi.org/10.1002/ijc.32286DOI Listing
March 2019
3 Reads

Prognostic value of low CDX2 expression in colorectal cancers with a high stromal content - a short report.

Cell Oncol (Dordr) 2019 Mar 8. Epub 2019 Mar 8.

Department of Surgery, Leiden University Medical Centrum, Albinusdreef 2, 2333ZA, Leiden, The Netherlands.

Purpose: Lack of expression of the intestinal transcription factor CDX2 in colorectal cancer (CRC) identifies patients with a poor prognosis. This biomarker has previously been suggested to be prognostic in CRCs with a high stromal content based on mRNA expression data. We investigated the prognostic value of CDX2 expression in microsatellite stable CRC stratified by stromal content using microscopy-based techniques. Read More

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http://dx.doi.org/10.1007/s13402-019-00436-0DOI Listing
March 2019
2 Reads

Clinicopathological and morphological spectrum of gastrointestinal stromal tumours on multi-detector computed tomography.

Pol J Radiol 2018 28;83:e545-e553. Epub 2018 Dec 28.

Department of Radio-Diagnosis, Father Muller Medical College, Karnataka, India.

Purpose: To describe the clinicopathological and morphological features of gastrointestinal stromal tumours (GISTs) on multi-detector computed tomography (MDCT).

Material And Methods: MDCT (plain and post contrast) images of 25 confirmed cases of GISTs were retrospectively evaluated from our hospital database. The images were analysed for the location, size, growth pattern, attenuation pattern, relation to adjacent structures, presence or absence of ulceration, calcification, metastases, lymphadenopathy, and for any complications such as haemorrhage, intestinal obstruction, etc. Read More

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http://dx.doi.org/10.5114/pjr.2018.81362DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6384412PMC
December 2018
2 Reads

Gastrointestinal stromal tumor leading to acute abdomen and hypovolemic shock in a trauma patient.

Ulus Travma Acil Cerrahi Derg 2019 Jan;25(1):83-85

Department of General Surgery, İstanbul Medicine Hospital, İstanbul-Turkey.

Gastrointestinal stromal tumors (GISTs) are among the rare tumors of gastrointestinal (GI) tract. GISTs occur respectively in the stomach, small intestines, colon and rectum, omentum and mesentery, esophagus, retroperitoneal space, and abdominal cavity. However, they may occur anywhere along the GI tract. Read More

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http://www.tjtes.org/eng/jvi.aspx?pdir=travma&plng=eng&a
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http://dx.doi.org/10.5505/tjtes.2018.35005DOI Listing
January 2019
9 Reads

Long-term adjuvant imatinib treatment for a patient who underwent complete resection of a localized recurrent gastrointestinal stromal tumor after preoperative imatinib treatment: A case report.

Medicine (Baltimore) 2019 Feb;98(6):e14477

Department of Gastrointestinal Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Rationale: The efficiency and tolerance of long-term adjuvant imatinib treatment for patient who underwent complete resection of a localized recurrent gastrointestinal stromal tumor (GIST) was unknown.

Patient Concerns: A 45-year-old man underwent complete resection of an intestinal GIST in August 2001. Four years later, a giant (11 × 8 × 6 cm) recurrent GIST located in the retroperitoneum was detected. Read More

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http://dx.doi.org/10.1097/MD.0000000000014477DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380822PMC
February 2019
2 Reads

Impact of in vitro driven expression signatures of CD133 stem cell marker and tumor stroma on clinical outcomes in gastric cancers.

BMC Cancer 2019 Feb 4;19(1):119. Epub 2019 Feb 4.

Cancer Research Institute, The Catholic University of Korea, Seoul, South Korea.

Background: The CD133 transmembrane protein is a well-recognized stem cell marker that has been used to isolate putative cancer stem cell populations from gastric cancers (GCs). However, the molecular features or biomarkers underlying CD133 are largely unknown in GCs.

Methods: We performed gene expression profiling of CD133+ and CD133- cells sorted by flow cytometry from three GC cell lines to identify the CD133 expression signatures of GC. Read More

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https://bmccancer.biomedcentral.com/articles/10.1186/s12885-
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http://dx.doi.org/10.1186/s12885-019-5332-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360664PMC
February 2019
6 Reads

[TNM classification of gynecologic malignancies : What remains to be done beyond 2017?]

Pathologe 2019 Feb;40(1):73-79

Pathologisches Institut, Ludwig-Maximilians-Universität München, München, Deutschland.

For some gynecologic malignancies, there are disagreements between the most recent WHO and TNM classifications and the recommendations of the International Collaboration of Cancer Reporting. These discrepancies are addressed and discussed in this paper. The WHO definition for primary vaginal cancer does not match the TNM definition. Read More

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http://dx.doi.org/10.1007/s00292-018-0559-yDOI Listing
February 2019
2 Reads

[Gastrointestinal Stromal Tumor of the Small Intestine with Dissemination Successfully Treated with Surgical Resection and Adjuvant Chemotherapy with Sunitinib-A Case Report].

Gan To Kagaku Ryoho 2018 Dec;45(13):2438-2440

Dept. of Surgery, Yamato Takada Municipal Hospital.

We report the case of a 73-year-old woman with repeated recurrent small intestinal gastrointestinal stromal tumor(GIST) who was referred to our hospital for best supportive care. She underwent surgical resection 4 times and developed recurrent tumors that were resistant to imatinib. She complained of right lower abdominal pain caused by the recurrent tumor. Read More

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December 2018
3 Reads

[A Case of Duodenal Gastrointestinal Stromal Tumor Resection with Preservation of the Pancreatic Head Following Chemotherapy with Imatinib].

Gan To Kagaku Ryoho 2018 Dec;45(13):2238-2240

Dept. of Surgery, Fujita Health University.

A 60-year-old male was admitted to our hospital on account of a duodenal submucosal tumor on the opposite side of Vater's papilla identified on a screening gastroduodenoscopy. The tumor was diagnosed as a duodenal gastrointestinal stromal tumor(GIST)due to positive c-kit and DOG1tests. Gastroduodenography and enhanced computed tomography showed a 50mm tumor widely invadingthe descendingportion of the duodenum close to the papilla of Vater and indicated the need for extended resection includingpancreaticoduodenectomy to achieve curation. Read More

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December 2018
1 Read

Tumors of the Ischiorectal Fossa: A Single-Institution Experience.

Dis Colon Rectum 2019 02;62(2):196-202

Surgical Outcomes Research Centre (SOuRCe), Sydney Local Health District, University of Sydney, Sydney, Australia.

Background: Ischiorectal fossa tumors are rare.

Objective: This study reviews a single institution's series of ischiorectal tumors with comparison against presacral tumors and assesses the utility of preoperative biopsy and angioembolization.

Design: This is a retrospective study. Read More

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http://dx.doi.org/10.1097/DCR.0000000000001249DOI Listing
February 2019
4 Reads

Collision Tumor of Adenocarcinoma and Gastrointestinal Stromal Tumor in the Small Bowel.

Case Rep Gastroenterol 2018 Sep-Dec;12(3):715-721. Epub 2018 Nov 28.

Department of Gastrointestinal and Pediatric Surgery, Tokyo Medical University Hospital, Tokyo, Japan.

We report a very rare case of collision tumor composed of primary adenocarcinoma of the jejunum and gastrointestinal stromal tumor (GIST). The patient was a 63-year-old man who visited our hospital for epigastralgia and vomiting. Abdominal computed tomography revealed a mass in the upper jejunum, with gastric and duodenal dilatation. Read More

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https://www.karger.com/Article/FullText/495246
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http://dx.doi.org/10.1159/000495246DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323411PMC
November 2018
18 Reads

Approach to wild-type gastrointestinal stromal tumors.

Transl Gastroenterol Hepatol 2018 15;3:92. Epub 2018 Nov 15.

Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA.

Gastrointestinal stromal tumors (GISTs) arise from the intestinal pacemaker cells of Cajal. Wild-type gastrointestinal stromal tumors (WT-GIST) are a unique and uncommon subtype of GISTs that lack activating mutations in the tyrosine kinase c-KIT or platelet derived growth factor receptor alpha (PDGFRA) receptors. The lack of these growth-stimulating mutations renders tyrosine kinase receptor inhibitors, such as imatinib mesylate, relatively ineffective against these tumors. Read More

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http://dx.doi.org/10.21037/tgh.2018.10.13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286923PMC
November 2018
3 Reads

Comparison of characteristic computed tomographic findings of gastrointestinal and non-gastrointestinal stromal tumors in the small intestine.

Abdom Radiol (NY) 2019 Apr;44(4):1237-1245

Department of Radiology, Shiga University of Medical Science, Seta, Tsukinowa-cho, Otsu City, Shiga, 520-2192, Japan.

Purpose: We aimed to reveal specific findings of gastrointestinal stromal tumors (GISTs) in the small intestine on contrast-enhanced computed tomography (CT) by comparing GISTs with non-GISTs.

Methods: We enrolled 28 patients with 39 GISTs and 20 patients with 22 non-GISTs who underwent enterectomy with a preoperative diagnosis of small intestinal tumor. All lesions were diagnosed by histopathological examination. Read More

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http://dx.doi.org/10.1007/s00261-018-1865-9DOI Listing
April 2019
2 Reads

Rapid emergence of cryptococcal fungemia, Mycobacterium chelonae vertebral osteomyelitis and gastro intestinal stromal tumor in a young HIV late presenter: a case report.

BMC Infect Dis 2018 Dec 27;18(1):693. Epub 2018 Dec 27.

Division of Infectious Diseases, Department of Clinical and Experimental Medicine, ARNAS Garibaldi Hospital, University of Catania, Catania, Italy.

Background: Highly active antiretroviral therapy has significantly changed the natural history of HIV infection, leading to a dramatic reduction of HIV-related morbidity and mortality. Late Presenters, Very Late Presenters and AIDS presenters still represent, also in Europe, including Italy, a huge challenge in terms of diagnostic and therapeutic management.

Case Presentation: A 35-year-old male with a history of fever and back pain. Read More

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http://dx.doi.org/10.1186/s12879-018-3573-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307234PMC
December 2018
5 Reads

Jejunal leiomyosarcoma: Report of a rare case diagnosed on cytology.

Diagn Cytopathol 2019 May 21;47(5):498-502. Epub 2018 Dec 21.

Department of Radiodiagnosis and Interventional Radiology, AIIMS, Jodhpur, India.

Jejunal leiomyosarcomas (LMS) are extremely rare. Of all the mesenchymal tumors of the small intestine, Gastrointestinal Stromal Tumors (GIST) comprise the majority. LMS of the small intestine have been documented as isolated reports or only a very small percentage of the smooth muscle tumors of the small intestine. Read More

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http://doi.wiley.com/10.1002/dc.24136
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http://dx.doi.org/10.1002/dc.24136DOI Listing
May 2019
11 Reads

Laparoscopic and endoscopic cooperative surgery (LECS) to overcome the limitations of endoscopic resection for colorectal tumors.

Endosc Int Open 2018 Dec 12;6(12):E1477-E1485. Epub 2018 Dec 12.

Gastroenterological Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan.

 We developed a laparoscopy endoscopy cooperative surgery (LECS) to overcome the limitations of endoscopic resection for colorectal tumors. The aim of this study was to evaluate the feasibility of LECS, which combines endoscopic submucosal dissection (ESD) and laparoscopic partial colectomy.  We performed LECS for 17 colorectal tumors in 17 patients (male:female 10:7; mean age, 66. Read More

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http://dx.doi.org/10.1055/a-0761-9494DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291397PMC
December 2018
2 Reads

A Rare Case of a Ruptured Metastatic Hepatic Lesion from a Jejunal Gastrointestinal Stromal Tumor (GIST) Treated by Arterial Embolization.

Am J Case Rep 2018 Dec 13;19:1480-1487. Epub 2018 Dec 13.

Department of General Surgery, Mount Lebanon Hospital, Beirut, Lebanon.

BACKGROUND Gastrointestinal stromal tumors (GISTs) are rare gastrointestinal neoplasms. The spontaneous rupture of a jejunal GIST is very rare and spontaneous rupture of liver metastasis from an intestinal GIST is even rarer with only a few cases reported in the literature. CASE REPORT In this article, we reported a case of spontaneous rupture of a liver metastasis from a malignant jejunal GIST that presented with active tumoral bleeding, hypovolemic shock, and hemoperitoneum. Read More

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http://dx.doi.org/10.12659/AJCR.910061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302770PMC
December 2018
2 Reads

Serum miR-518e-5p is a potential biomarker for secondary imatinib-resistant gastrointestinal stromal tumor.

J Biosci 2018 Dec;43(5):1015-1023

Department of Gastrointestinal and Nutriology Surgery, Affiliated Shengjing Hospital of China Medical University, Shenyang 110004, China.

Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumor of the intestinal tract. Imatinib is used as first-line therapy for GIST patients; however, secondary imatinib resistance poses a significant clinical challenge. Here, we analyzed serum miRNA expression profiles to identify specific serum miRNAs that could be used as early diagnostic markers. Read More

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December 2018
3 Reads

Tumor heterogeneity in gastrointestinal stromal tumors of the small bowel: volumetric CT texture analysis as a potential biomarker for risk stratification.

Cancer Imaging 2018 Dec 5;18(1):46. Epub 2018 Dec 5.

Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Qiaokou District, Wuhan, 430030, China.

Background: To explore whether volumetric CT texture analysis (CTTA) can serve as a potential imaging biomarker for risk stratification of small bowel gastrointestinal stromal tumors (small bowel-GISTs).

Methods: A total of 90 patients with small bowel-GISTs were retrospectively reviewed, of these, 26 were rated as high risk, 13 as intermediate risk, and 51 as low or very low risk. Histogram parameters extracted from CT images were compared among small bowel-GISTs with different risk levels by using one-way analysis of variance. Read More

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https://cancerimagingjournal.biomedcentral.com/articles/10.1
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http://dx.doi.org/10.1186/s40644-018-0182-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280355PMC
December 2018
14 Reads

[Analysis of clinical features and prognostic factors on reoperation patients with postoperative recurrence or metastasis of gastrointestinal stromal tumor].

Zhonghua Wei Chang Wai Ke Za Zhi 2018 Nov;21(11):1274-1279

Ward III Gastrointestinal Surgery, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Institute of Digestive Surgery, Shanghai 200025,

Objective: To investigate the clinical characteristics and prognostic factors of reoperation patients with postoperative recurrence or metastasis of gastrointestinal stromal tumor (GIST).

Methods: A retrospective case-control study was performed on the clinical data of 31 patients with GIST who had recurrence or metastasis after the first surgery and underwent one or more operations again from February 2003 to January 2016 at Ruijin Hospital, Shanghai Jiaotong University School of Medicine. The clinical characteristics of these patients were analyzed. Read More

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November 2018
3 Reads

Surgical treatment of giant gist with acute gastrointestinal bleeding: Case report.

Int J Surg Case Rep 2018 16;53:354-357. Epub 2018 Nov 16.

General Surgery Department, Coimbra Hospital and University Center, Praceta Prof. Mota Pinto, 3000-075 Coimbra, Portugal. Electronic address:

Introduction: Gastrointestinal stromal tumors represent about 1% of the tumors of digestive tract. Their presentation consists often of indolent symptoms. However, they can present as surgical emergencies in rare cases. Read More

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http://dx.doi.org/10.1016/j.ijscr.2018.11.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260360PMC
November 2018
1 Read

Overview of MDM2 and B-RAF Expression in Gastric Lesions.

Open Access Maced J Med Sci 2018 Oct 10;6(10):1795-1802. Epub 2018 Oct 10.

Department of Hepato-Gastroenterology, Theodor Bilharz Research Institute, Giza, Egypt.

Background: Globally, gastric cancer (GC) it is the fourth most common cancer and the third cause of cancer-related deaths. Overexpression of MDM2 and B-RAF appeared to be increased in malignancy and associated with poor prognosis in several human tumours, but their role in gastric cancer remains controversial.

Aim: We had investigated the immunohistochemical expression of MDM2 and B-RAF in 136 gastric lesions with/without association. Read More

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http://www.id-press.eu/mjms/article/view/1784
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http://dx.doi.org/10.3889/oamjms.2018.338DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236038PMC
October 2018
17 Reads

Clinicopathological characteristics and prognosis of primary appendiceal stromal tumors.

World J Surg Oncol 2018 Nov 16;16(1):225. Epub 2018 Nov 16.

Department of Gastric Surgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, No.44 Xiaoheyan Road, Dadong District, Shenyang, 110042, Liaoning Province, People's Republic of China.

Background: Gastrointestinal stromal tumors (GISTs) account for less than 1% of all gastrointestinal tumors. The biological behaviors of GISTs vary from benign to malignant. GISTs are common in the stomach (55. Read More

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https://wjso.biomedcentral.com/articles/10.1186/s12957-018-1
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http://dx.doi.org/10.1186/s12957-018-1524-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240235PMC
November 2018
23 Reads

Intestinal occlusion by stenotic neuroendocrine tumours of left colon and concomitant association with small bowel gastrointestinal stromal tumours: A case report.

Int J Surg Case Rep 2018 26;53:182-185. Epub 2018 Oct 26.

Dept of Emergency and Organ Transplantation, General Surgery Unit "G. Marinaccio", University "Aldo Moro" of Bari, Bari, Italy.

Introduction: The association between Gastrointestinal Stromal Tumours (GIST) and Neuroendocrine Tumours (NET) is very rare. These tumours have various clinical expressions and sometimes are asymptomatic. Synchronous NETs and GISTs have been already described in literature in few case reports. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22102612183045
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http://dx.doi.org/10.1016/j.ijscr.2018.10.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222084PMC
October 2018
17 Reads

The assessment of different risk classification systems for gastrointestinal stromal tumors (GISTs): the analytic results from the SEER database.

Scand J Gastroenterol 2018 Oct - Nov;53(10-11):1319-1327. Epub 2018 Oct 24.

a Department of Surgical Oncology , First Affiliated Hospital of China Medical University , Shenyang , P.R. China.

Background: Although various risk classification systems for GISTs have been proposed, the optimum one remains uncertain. In the present study, we compared the prognostic stratification of different risk classification systems for GIST patients.

Methods: We reviewed those patients who were pathologically diagnosed with GISTs in the SEER database between 2009 and 2014. Read More

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http://dx.doi.org/10.1080/00365521.2018.1515319DOI Listing
April 2019
13 Reads

Laparoscopic management of giant gastrointestinal stromal tumor masquerading as infected mesenteric cyst.

Ann Ital Chir 2018 ;89:342-346

Gastrointestinal stromal tumors (GISTs) are the most common non-epithelial (mesenchymal) tumors of the gastrointestinal tract. Although GISTs appear as solid and well-circumscribed lesions in most patients, they may also appear as solid- cystic (mixed) or pure cystic lesions due to reasons like intra-tumor hemorrhage and necrosis in a very small percentage of patients. Hence, cystic GISTs mostly lead to a diagnostic dilemma. Read More

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January 2018
10 Reads

Retrospective evaluation of toceranib phosphate (Palladia®) use in the treatment of gastrointestinal stromal tumors of dogs.

J Vet Intern Med 2018 Nov 11;32(6):2045-2053. Epub 2018 Oct 11.

Veterinary Clinical Sciences, Iowa State University College of Veterinary Medicine, Ames, Iowa.

Background: Gastrointestinal stromal tumors (GISTs) are uncommon intestinal neoplasms in the dog. Literature regarding adjunctive therapy for GISTs in dogs is sparse. High-risk GISTs in humans respond to tyrosine kinase inhibition in the adjuvant setting. Read More

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http://doi.wiley.com/10.1111/jvim.15335
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http://dx.doi.org/10.1111/jvim.15335DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271363PMC
November 2018
8 Reads

Histopathological Analysis of 173 Consecutive Patients with Colorectal Carcinoma: A Pathologist's View.

Med Sci Monit 2018 Sep 26;24:6809-6815. Epub 2018 Sep 26.

Department of General Surgery, Health Sciences University, Kartal Research and Education Hospital, Istanbul, Turkey.

BACKGROUND Worldwide, colorectal carcinomas are the third most common carcinomas in men and the second most common carcinomas in women. Pathological examination of rectum specimens requires special attention for correctly evaluating many prognostically important factors. In this study, we present pathological results of 173 lower anterior resection (LAR) and abdominoperineal resection (APR) specimens retrospectively evaluated. Read More

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http://dx.doi.org/10.12659/MSM.911012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6178881PMC
September 2018
4 Reads

Lesion size determines diagnostic yield of EUS-FNA with onsite cytopathologic evaluation for upper gastrointestinal subepithelial lesions.

Turk J Gastroenterol 2018 07;29(4):436-441

Department of Pathology, American Hospital, İstanbul, Turkey; Department of Pathology, Mehmet Ali Aydınlar Acıbadem University School of Medicine, İstanbul, Turkey.

Background/aims: The aim of this study was to determine the diagnostic yield and factors influencing the diagnostic yield of endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) for upper gastrointestinal (GI) subepithelial lesions (SELs) with rapid onsite cytopathologic evaluation.

Materials And Methods: This is a single-center, retrospective study.

Results: Among 22 patients who underwent EUS-FNA, a cytopathological diagnosis was reached in 16 (72. Read More

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http://www.turkjgastroenterol.org/eng/makale/5326/308/Full-T
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http://dx.doi.org/10.5152/tjg.2018.17876DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284628PMC
July 2018
3 Reads

Severe Acute Gastrointestinal Bleed in a Patient With Neurofibromatosis Type 1.

Gastroenterology 2019 02 8;156(3):e1-e2. Epub 2018 Sep 8.

Division of Gastroenterology and Hepatology, Rutgers New Jersey Medical School, Newark, New Jersey.

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http://dx.doi.org/10.1053/j.gastro.2018.09.011DOI Listing
February 2019
2 Reads

Laparoscopic versus open resection of gastrointestinal stromal tumors: survival outcomes from the NCDB.

Surg Endosc 2019 Mar 31;33(3):923-932. Epub 2018 Aug 31.

Department of Surgery, University of California Irvine Medical Center, Orange, CA, USA.

Background: Studies comparing laparoscopic versus open resection of gastrointestinal stromal tumors (GIST) typically involve small comparative groups and often do not control for tumor size or stage of disease. The objective of this study was to compare adjusted survival outcomes for laparoscopic versus open GIST.

Method: The National Cancer Database (NCDB) from 2010 to 2014 was evaluated for gastric and small intestinal GIST resections. Read More

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http://dx.doi.org/10.1007/s00464-018-6393-8DOI Listing
March 2019
8 Reads

[Tumors of the small bowel: about 27 cases].

Pan Afr Med J 2018 8;30:13. Epub 2018 May 8.

Service d'Hépato-Gastroentérologie C4, CHU Hassan II, Faculté de Médecine et de Pharmacie, Université Sidi Mohammed Ben Abdallah, Sidi Hrazem, Fès, Maroc.

Tumors of the small bowel account for 5% of all tumors of the gastrointestinal tract. Although important progress has been made from a radiological and endoscopic point of view, they have a poor prognosis due to delayed diagnosis. This occurs because of the absence of clinical manifestations and of the difficulties of exploration. Read More

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http://www.panafrican-med-journal.com/content/article/30/13/
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http://dx.doi.org/10.11604/pamj.2018.30.13.5407DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6110553PMC
September 2018
26 Reads

Comparing the long-term outcomes among patients with stomach and small intestine gastrointestinal stromal tumors: An analysis of the National Cancer Database.

J Surg Oncol 2018 Sep 21;118(3):486-492. Epub 2018 Aug 21.

Department of Surgery, Yale School of Medicine, New Haven, Connecticut.

Background And Objectives: Gastrointestinal stromal tumors (GIST) are the most common sarcoma arising from the gastrointestinal tract. Data regrading long-term prognosis based on tumor location (stomach vs small intestine) are mixed, so we aimed to analyze their outcomes using a large national oncology database.

Methods: The National Cancer Database was queried for cases of stomach and small intestine GIST between the years 2004 and 2014. Read More

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http://dx.doi.org/10.1002/jso.25172DOI Listing
September 2018
3 Reads

Management of a case of high-risk gastrointestinal stromal tumor in rectum by transanal minimal invasive surgery.

World J Surg Oncol 2018 Aug 11;16(1):165. Epub 2018 Aug 11.

Department of Digestive Surgery, Breast and Thyroid Surgery, Graduate School of Medicine, Kagoshima University, Sakuragaoka 8-35-1, Kagoshima, 890-8520, Japan.

Background: Rectal gastrointestinal stromal tumor (GIST) is a very rare tumor of gastrointestinal tract. Surgical management of rectal GIST requires special attention for preserving of anal and urinary functions. Transanal minimal invasive surgery (TAMIS) is a well-developed minimally invasive technique for local excision of benign and early malignant rectal tumors; however, the application of TAMIS for rectal GIST is rarely and inadequately reported. Read More

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http://dx.doi.org/10.1186/s12957-018-1463-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6087008PMC
August 2018
15 Reads

Chromogranin A: From Laboratory to Clinical Aspects of Patients with Neuroendocrine Tumors.

Int J Endocrinol 2018 2;2018:8126087. Epub 2018 Jul 2.

Endocrinological Oncology, Service of Endocrinology, A.O. San Camillo-Forlanini, Rome, Italy.

. Neuroendocrine tumors (NETs) are characterized by having behavior and prognosis that depend upon tumor histology, primary site, staging, and proliferative index. The symptoms associated with carcinoid syndrome and vasoactive intestinal peptide tumors are treated with octreotide acetate. Read More

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http://dx.doi.org/10.1155/2018/8126087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6051263PMC
July 2018
5 Reads

Outcomes After Surgical Resection Differ by Primary Tumor Location for Metastatic Gastrointestinal Stromal Tumors (GISTs): a Propensity Score Matching Population Study.

J Gastrointest Cancer 2018 Jul 23. Epub 2018 Jul 23.

Second Department of Surgery, University General Hospital of Alexandroupoli, Democritus University of Thrace Medical School, 68100, Alexandroupoli, Greece.

Purpose: Primary tumor location has been identified as an important prognostic factor among patients with gastrointestinal stromal tumors (GISTs). The purpose of this study is to identify how primary tumor location may affect outcomes after resection for patients with metastatic GISTs.

Methods: Patients with GISTs and distant metastases at diagnosis were identified in the Surveillance Epidemiology and End Results (SEER) database. Read More

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http://dx.doi.org/10.1007/s12029-018-0137-9DOI Listing
July 2018
6 Reads

[A Case of Rectal Gastrointestinal Stromal Tumor(GIST)Treated with Imatinib Mesylate Neoadjuvant Therapy to Preserve the Anus].

Gan To Kagaku Ryoho 2018 Jun;45(6):981-984

Dept. of Surgery, Asahikawa-Kosei General Hospital.

A woman in her 40's who initially presented with anal pain was diagnosed with rectal GIST. A 9 cm tumor extended to near the anus, and curative abdominoperineal tumor resection was required. The patient initially received neoadjuvant therapy with imatinib mesylate. Read More

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June 2018
4 Reads

Evaluation of Clinical Plus Imaging Features and Multidetector Computed Tomography Texture Analysis in Preoperative Risk Grade Prediction of Small Bowel Gastrointestinal Stromal Tumors.

J Comput Assist Tomogr 2018 Sep/Oct;42(5):714-720

Department of Orthopaedic Oncology, Changzheng Hospital, Second Military Medical University, Shanghai, China.

Objective: This study aimed to evaluate the prediction roles of clinical plus imaging features and multidetector computed tomography (MDCT) texture analysis in preoperative risk grade classification of small bowel (SB) gastrointestinal stromal tumors (GISTs).

Methods: This study included 213 SB GIST patients. Clinical features and MDCT imaging findings were reviewed. Read More

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http://dx.doi.org/10.1097/RCT.0000000000000756DOI Listing
September 2018
1 Read

Duodenal neuroendocrine tumor, adenocarcinoma and gastrointestinal stromal tumor in association with neurofibromatosis type 1: An unique occurrence.

Indian J Pathol Microbiol 2018 Jul-Sep;61(3):401-403

Department of Pathology, Sagar Hospital, Bengaluru, Karnataka, India.

Mixed endocrine-nonendocrine neoplasms are rare tumors and pose challenges in diagnosis and management. Neurofibromatosis-1 (NF-1) patients are known to develop malignancies. Although neuroendocrine tumors and gastro-intestinal stromal tumors are seen in NF-1, its association with adenocarcinoma is rare. Read More

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http://dx.doi.org/10.4103/IJPM.IJPM_534_17DOI Listing
November 2018
4 Reads

Clinicopathologic features and prognostic grouping of gastrointestinal stromal tumors (GISTs) in Pakistani patients: an institutional perspective.

BMC Res Notes 2018 Jul 11;11(1):457. Epub 2018 Jul 11.

Department of Medicine, Kandahar University, Kandahar, Afghanistan.

Objectives: Gastrointestinal stromal tumors (GISTs) are rare tumors of gastrointestinal tract, prognosis of which largely depends upon histopathologic characteristics of resection specimens, which were not widely studied in our population. Therefore we aimed to evaluate the histopathologic characteristics of GISTs in our population and their prognostic grouping according to college of American pathologist's guidelines.

Results: Mean age of patients was 53. Read More

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http://dx.doi.org/10.1186/s13104-018-3562-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6042430PMC
July 2018
4 Reads

Postoperative imatinib in patients with intermediate risk gastrointestinal stromal tumor.

Future Oncol 2018 Jul 4;14(17):1721-1729. Epub 2018 Jul 4.

Department of GI Oncology, Laboratory of Carcinogenesis & Translational Research for the Ministry of National Education, Peking University School of Oncology, Beijing Cancer Hospital & Institute, Beijing 100142, PR China.

Aim: To determine whether imatinib adjuvant treatment improved recurrence-free survival (RFS) in gastrointestinal stromal tumor (GIST) with intermediate risk.

Materials & Methods: Patients who had undergone complete tumor resection with intermediate risk were enrolled.

Results: A total of 99 patients received imatinib adjuvant therapy and 93 patients only received observation. Read More

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http://dx.doi.org/10.2217/fon-2017-0691DOI Listing
July 2018
43 Reads

Laparoscopic Partial Sleeve Duodenectomy for the Infra-Ampullary Gastrointestinal Stromal Tumors of the Duodenum.

World J Surg 2018 12;42(12):4005-4013

Pancreatobiliary Cancer Center, Yonsei Cancer Center, Severance Hospital, Seoul, Korea.

Background: Although organ-preserving operations are regarded as effective strategies for duodenal gastrointestinal stromal tumors (GISTs), laparoscopic partial sleeve duodenectomy (lap PSD) has not been fully evaluated. The aims of this study were to evaluate the effectiveness and technical feasibility of lap PSD.

Study Design: Between January 2011 and March 2016, we reviewed 13 patients who underwent laparoscopic approach among 22 patients who underwent PSD. Read More

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http://dx.doi.org/10.1007/s00268-018-4707-6DOI Listing
December 2018
21 Reads

Telomere length alterations in microsatellite stable colorectal cancer and association with the immune response.

Biochim Biophys Acta Mol Basis Dis 2018 09 14;1864(9 Pt B):2992-3000. Epub 2018 Jun 14.

Unit of Biomarkers and Susceptibility, Cancer Prevention and Control Program, Catalan Institute of Oncology (ICO), Oncobell Program, Bellvitge Biomedical Research Institute (IDIBELL) and CIBERESP, L'Hospitalet de Llobregat, Barcelona, Spain; Department of Clinical Sciences, Faculty of Medicine and Health Sciences, University of Barcelona, Barcelona, Spain. Electronic address:

Telomeres are repetitive sequences (TTAGGG) located at the end of chromosomes. Telomeres progressively shorten with each cell replication cycle, ultimately leading to chromosomal instability and loss of cell viability. Telomere length anomaly appears to be one of the earliest and most prevalent genetic alterations in malignant transformation. Read More

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http://dx.doi.org/10.1016/j.bbadis.2018.06.010DOI Listing
September 2018
23 Reads
4.882 Impact Factor

Myeloid p38α signaling promotes intestinal IGF-1 production and inflammation-associated tumorigenesis.

EMBO Mol Med 2018 07;10(7)

Institute for Research in Biomedicine (IRB Barcelona), Barcelona Institute of Science and Technology, Barcelona, Spain

The protein kinase p38α plays a key role in cell homeostasis, and p38α signaling in intestinal epithelial cells protects against colitis-induced tumorigenesis. However, little is known on the contribution of p38α signaling in intestinal stromal cells. Here, we show that myeloid cell-specific downregulation of p38α protects mice against inflammation-associated colon tumorigenesis. Read More

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http://dx.doi.org/10.15252/emmm.201708403DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6034132PMC
July 2018
2 Reads

[Gastrointestinal leiomyoma with interstitial cells of Cajal: mimicker of gastrointestinal stromal tumor].

Zhonghua Bing Li Xue Za Zhi 2018 Jun;47(6):438-443

Department of Pathology, the Second Affiliated Hospital of Zhengzhou University, Zhengzhou 450014, China.

To study clinical and pathologic characteristics of leiomyomas of the gastrointestinal tract, and to investigate the distribution characteristics of interstitial cells of Cajal ( ICCs ) in gastrointestinal leiomyomas. One hundred and forty-seven cases of leiomyomas of gastrointestinal tract were collected at the Second Affiliated Hospital of Zhengzhou University from June 2012 to June 2017. Clinical and pathologic findings were analyzed, combined with immunohistochemistry, Alcian blue-osafranin staining and molecular study. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0529-5807.2018.06.010DOI Listing
June 2018
18 Reads

A gastrointestinal stromal tumor of the jejunum presenting with an intratumoral abscess: A case report and a literature review.

Int J Surg Case Rep 2018 29;48:65-68. Epub 2018 May 29.

Department of Surgery, Iwate Prefectural Iwai Hospital, 17 Odaira, Kozenji, Ichinoseki, Iwate, 029-0192, Japan.

Introduction: Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract. The small intestine is the second-most frequent location where GISTs occur after the stomach. Attention should be paid to small intestinal GISTs because they infrequently present with acute abdomen, which necessitates emergency surgery. Read More

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http://dx.doi.org/10.1016/j.ijscr.2018.05.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6014644PMC
May 2018
5 Reads
1 Citation