2,421 results match your criteria Intestinal Stromal Tumors


[Gastrointestinal stromal tumors: potential of minimally invasive surgical interventions].

Khirurgiia (Mosk) 2022 (5):25-33

National Medical Research Centre for Oncology, Rostov-on-Don, Russia.

Objective: To analyze the issue of gastrointestinal stromal tumors (GISTs) and potential of minimally invasive surgical interventions.

Material And Methods: We analyzed postoperative outcomes in 97 patients with gastric and intestinal GISTs who underwent surgical treatment at the National Medical Research Centre for Oncology between 2015 and 2020.

Results: Twenty (24. Read More

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January 2022

Solid Pseudopapillary Neoplasm of the Pancreas Presenting With Gastric Outlet Obstruction.

Cureus 2022 Apr 13;14(4):e24092. Epub 2022 Apr 13.

Gastroenterology, School of Digestive and Liver Diseases, Institute of Postgraduate Medical Education and Research, Kolkata, IND.

Solid pseudopapillary neoplasm (SPN) of the pancreas are rare tumors accounting for a minor portion of all exocrine pancreatic tumors. It usually occurs in young women. It has a very low malignant potential with a relatively indolent clinical course. Read More

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Comparative Study of the Role of Interepithelial Mucosal Mast Cells in the Context of Intestinal Adenoma-Carcinoma Progression.

Cancers (Basel) 2022 Apr 30;14(9). Epub 2022 Apr 30.

Institute of Pathology, School of Medicine, Technical University of Munich, 81675 Munich, Germany.

Mast cells (MCs) are crucial players in the relationship between the tumor microenvironment (TME) and cancer cells and have been shown to influence angiogenesis and progression of human colorectal cancer (CRC). However, the role of MCs in the TME is controversially discussed as either pro- or anti-tumorigenic. Genetically engineered mouse models (GEMMs) are the most frequently used in vivo models for human CRC research. Read More

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Paracrine signalling between intestinal epithelial and tumour cells induces a regenerative programme.

Elife 2022 May 11;11. Epub 2022 May 11.

Institut Curie, Laboratory of Genetics and Developmental Biology, PSL Research University, INSERM U934, CNRS UMR3215, Paris, France.

Tumours are complex ecosystems composed of different types of cells that communicate and influence each other. While the critical role of stromal cells in affecting tumour growth is well established, the impact of mutant cancer cells on healthy surrounding tissues remains poorly defined. Here, using mouse intestinal organoids, we uncover a paracrine mechanism by which intestinal cancer cells reactivate foetal and regenerative YAP-associated transcriptional programmes in neighbouring wildtype epithelial cells, rendering them adapted to thrive in the tumour context. Read More

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Reconstructing physical cell interaction networks from single-cell data using Neighbor-seq.

Nucleic Acids Res 2022 May 10. Epub 2022 May 10.

Rutgers Cancer Institute of New Jersey, Rutgers the State University of New Jersey, New Brunswick, NJ 08901, USA.

Cell-cell interactions are the fundamental building blocks of tissue organization and multicellular life. We developed Neighbor-seq, a method to identify and annotate the architecture of direct cell-cell interactions and relevant ligand-receptor signaling from the undissociated cell fractions in massively parallel single cell sequencing data. Neighbor-seq accurately identifies microanatomical features of diverse tissue types such as the small intestinal epithelium, terminal respiratory tract, and splenic white pulp. Read More

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Laparoscopic distal gastrectomy for synchronous adenocarcinoma, diffuse large B cell lymphoma and gastrointestinal stromal tumor in the stomach: a case report.

Surg Case Rep 2022 May 8;8(1):89. Epub 2022 May 8.

Second Department of Surgery, School of Medicine, Wakayama Medical University, 811-1, Kimiidera, Wakayama, 641-8510, Japan.

Background: Synchronous lymphoma and adenocarcinoma are occasionally detected in the stomach. Gastrointestinal stromal tumor (GIST) and adenocarcinoma are sometimes seen simultaneously in the stomach. However, we rarely observe synchronous adenocarcinoma, lymphoma, and GIST in the stomach, and there are few reports on cases with these three lesions. Read More

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Extremely Aggressive Mesenteric Extragastrointestinal Stromal Tumor: A Case Report and Literature Review.

Cureus 2022 Mar 12;14(3):e23108. Epub 2022 Mar 12.

Oncology, Longstreet Clinic Cancer Center, Gainesville, USA.

Gastrointestinal stromal tumors (GISTs) are rare tumors with increasing incidence. GIST is the most common mesenchymal tumor of the gastrointestinal tract involving the elderly population with a slow progression. It originates from the interstitial cells of Cajal. Read More

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15-Year-Old Patient with an Unusual Alpha-Fetoprotein-Producing Sertoli-Leydig Cell Tumor of Ovary.

Case Rep Obstet Gynecol 2022 12;2022:4759826. Epub 2022 Apr 12.

Department of Pathology, Brugmann University Hospital Center, Université Libre de Bruxelles, Belgium.

Ovarian Sertoli-Leydig cell tumors (SLCTs) are extremely rare ovarian sex-cord stromal tumors. Alpha-fetoprotein (AFP) production by SLCTs is a rare event generally linked to the presence of hepatocytes or intestinal mucinous epithelium as heterologous elements. We report here a case of a 15-year-old female complaining about abdominal pain, constipation, and spaniomenorrhea with high level of serum AFP leading to a clinical suspicion of malignant germ cell tumor. Read More

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Loss of DRO1/CCDC80 in the tumor microenvironment promotes carcinogenesis.

Oncotarget 2022 11;13:615-627. Epub 2022 Apr 11.

Department of Medicine II, Ludwig Maximilian University of Munich, Munich 81377, Germany.

Tumors are composed of the tumor cells and the surrounding microenvironment. Both are closely interwoven and interact by a complex and multifaceted cross-talk which plays an integral part in tumor initiation, growth, and progression. has been shown to be a potent suppressor of colorectal cancer and ubiquitous inactivation of strongly promoted colorectal carcinogenesis in mice and in a chemically-induced colorectal cancer model. Read More

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[Jejunal stromal tumor concomitant ectopic pancreas in a young man with sarcoidosis:a case report].

Nihon Shokakibyo Gakkai Zasshi 2022 ;119(4):342-350

Department of Pathology, Ageo Central General Hospital.

During a medical health check, a 29-year-old man was presented to our hospital with iron deficiency anemia. He had no significant medical history in his family. Despite being diagnosed with ocular sarcoidosis 5 years ago, he had no vision problems. Read More

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Gastrointestinal stromal tumors with gene mutation in 4 guinea pigs ().

Vet Pathol 2022 Apr 8:3009858221087630. Epub 2022 Apr 8.

Setsunan University, Hirakata, Osaka, Japan.

Gastrointestinal stromal tumors (GISTs) have been rarely reported in guinea pigs. We aimed to characterize the clinical and pathological features of GISTs in 4 guinea pigs and investigate the presence of mutations in exon 11 of the KIT proto-oncogene receptor tyrosine kinase () gene. Two subjects were male and 2 were female; 2 were 6 years old, 1 was 7 years old, and 1 was of an unknown age. Read More

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Patient demographics, clinicopathologic features, and outcomes in wild-type gastrointestinal stromal tumor: a national cohort analysis.

Sci Rep 2022 04 6;12(1):5774. Epub 2022 Apr 6.

Surgical Oncology Program, National Cancer Institute, 9000 Rockville Pike Building 10, Room 4-3760, Bethesda, MD, 20892, USA.

Wild-type KIT and PDGFRA gastrointestinal stromal tumors (GIST) are rare tumors with limited treatment options. We sought to determine the clinicopathologic features of wild-type GIST and identify factors that influence overall survival (OS) using a large national database. Retrospective evaluation of patients with wild-type GIST in the National Cancer Database (NCDB) was performed. Read More

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Systemic Deficiency of PTEN Accelerates Breast Cancer Growth and Metastasis.

Front Oncol 2022 18;12:825484. Epub 2022 Mar 18.

Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University, Lanzhou, China.

Mutation or loss of the tumor suppressor gene or its functional status in tumor stromal cells may affect tumor occurrence, development, invasion, and metastasis, in which, however, the role of overall low PTEN expression, mutation, or deletion in the tumor-bearing host has rarely been reported. Breast cancer is a common highly invasive metastatic tumor. We therefore treated mouse breast cancer 4T1 cells with the specific PTEN inhibitor VO-OHpic to study the effects of PTEN suppression or deletion on malignant behavior and . Read More

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Pro-Inflammatory Cytokines Trigger the Overexpression of Tumour-Related Splice Variant RAC1B in Polarized Colorectal Cells.

Cancers (Basel) 2022 Mar 9;14(6). Epub 2022 Mar 9.

Department of Human Genetics, National Institute of Health 'Dr. Ricardo Jorge', 1649-016 Lisbon, Portugal.

An inflammatory microenvironment is a tumour-promoting condition that provides survival signals to which cancer cells respond with gene expression changes. One example is the alternative splicing variant Rat Sarcoma Viral Oncogene Homolog (Ras)-Related C3 Botulinum Toxin Substrate 1 (RAC1)B, which we previously identified in a subset of V-Raf Murine Sarcoma Viral Oncogene Homolog B (BRAF)-mutated colorectal tumours. RAC1B was also increased in samples from inflammatory bowel disease patients or in an acute colitis mouse model. Read More

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Diagnosing gastrointestinal stromal tumors: The utility of fine-needle aspiration cytology versus biopsy.

Cancer Med 2022 Mar 17. Epub 2022 Mar 17.

Department of Clinical Pathology and Cytology, Karolinska University Hospital, Stockholm, Sweden.

Background: Gastrointestinal stromal tumors (GIST) are mesenchymal tumors in the intestinal tract originating from a precursor to the interstitial cells of Cajal, which plays a role in gastric motility. The preoperative diagnosis of GIST may be very important for the surgical approach or the need for neoadjuvant treatment and is often done in conjunction with molecular testing.

Design: GISTs diagnosed in Stockholm between 1999 and 2019 with biopsy and/or fine-needle aspiration (FNA) material were included. Read More

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[A Case of Rectal GIST Resected using the TAMIS Method].

Gan To Kagaku Ryoho 2022 Mar;49(3):312-314

Dept. of Gastroenterological Surgery, Nippon Life Hospital.

We reported a case of rectal gastrointestinal stromal tumor(GIST)performed transanal surgery. A 46-year-old woman was pointed out uterinal cancer and lower rectal GIST. After operation for uterine cancer, GIST was treated. Read More

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A Low rectal GIST.

BMJ Case Rep 2022 Mar 14;15(3). Epub 2022 Mar 14.

Colorectal Surgery, Cleveland Clinic Main Campus Hospital, Cleveland, Ohio, USA.

A man in his 70s presented with narrowing of his stool calibre and a palpable mass on rectal examination. Colonoscopy revealed a submucosal bulge without a mucosal lesion. CT and MRI demonstrated an 8×5. Read More

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Aberrant tryptophan metabolism in stromal cells is associated with mesenteric fibrosis in small intestinal neuroendocrine tumors.

Endocr Connect 2022 Apr 29;11(4). Epub 2022 Apr 29.

Department of Internal Medicine, Section Endocrinology, Erasmus University Medical Center and Erasmus MC Cancer Institute, Rotterdam, Netherlands.

Background: Increased levels of serotonin secretion are associated with mesenteric fibrosis (MF) in small intestinal neuroendocrine tumors (SI-NETs). However, the profibrotic potential of serotonin differs between patients, and in this study, we aimed to gain an understanding of the mechanisms underlying this variability. To this end, we analyzed the proteins involved in tryptophan metabolism in SI-NETs. Read More

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Duodenal gastrointestinal stromal tumour imitating as pancreatic head tumour.

BMJ Case Rep 2022 Mar 1;15(3). Epub 2022 Mar 1.

Pathology, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India.

Duodenal gastrointestinal stromal tumours (D-GISTs) are a rare disease. It may arise commonly from the second or third part of the duodenum and can be erroneously diagnosed as a pancreatic head tumour due to proximity and morphology on imaging studies. We present a case of a 60-year-old woman who presented with abdominal pain and was diagnosed as a case of pancreatic neuroendocrine tumour on radiologic imaging and granulomatous lesion on aspiration cytology. Read More

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Epithelioid Gastrointestinal Stromal Tumor of Duodenum Mimicking Adenocarcinoma: A Case Report.

JNMA J Nepal Med Assoc 2021 Dec 11;59(244):1310-1312. Epub 2021 Dec 11.

Department of Pathology, Mahajargunj Medical Campus, Kathmandu, Nepal.

Gastrointestinal stromal tumor is a mesenchymal tumor of gastro-intestinal tract. This epithelioid type gastrointestinal stromal tumor seen in a 22-year-old male with epigastric pain as a presenting symptom had morphological resemblance to carcinoma. However, the immunohistochemistry profile with CD117 and DOG 1 positivity, combined with AE1/AE3 positivity confirmed the tumor as gastrointestinal stromal tumor. Read More

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December 2021

Revealing the transcriptional heterogeneity of organ-specific metastasis in human gastric cancer using single-cell RNA Sequencing.

Clin Transl Med 2022 02;12(2):e730

Pharmaceutical Informatics Institute, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.

Background: Deciphering intra- and inter-tumoural heterogeneity is essential for understanding the biology of gastric cancer (GC) and its metastasis and identifying effective therapeutic targets. However, the characteristics of different organ-tropism metastases of GC are largely unknown.

Methods: Ten fresh human tissue samples from six patients, including primary tumour and adjacent non-tumoural samples and six metastases from different organs or tissues (liver, peritoneum, ovary, lymph node) were evaluated using single-cell RNA sequencing. Read More

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February 2022

Surgical strategies for duodenal gastrointestinal stromal tumors.

Langenbecks Arch Surg 2022 Mar 18;407(2):835-844. Epub 2022 Feb 18.

Department of Pancreatic Surgery, West China Hospital, Sichuan University, Chengdu, China.

Purpose: Duodenal gastrointestinal stromal tumors (GISTs) are rare mesenchymal tumors of the gastrointestinal tract. For localized or potentially resectable GISTs, surgery is the first choice. But the important and complex anatomical structure adjacent to the duodenum makes surgical management for duodenal GISTs challenging and few comprehensive surgical strategies have been described. Read More

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Robotic Excision of Rectal GI Stromal Tumor Using the Da Vinci Xi System.

Dis Colon Rectum 2022 05;65(5):e323

Department of Colorectal surgery, Korea University Anam Hospital, South Korea.

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Risk stratification of oesophageal, colonic, and appendiceal gastrointestinal stromal tumours (GISTs) using the new Nashville risk score.

Histopathology 2022 04 28;80(5):874-875. Epub 2022 Feb 28.

Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.

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Inflammatory myofibroblastic tumour of the rectum with a novel anaplastic lymphoma kinase fusion diagnosed on cytology: Not just another submucosal gastrointestinal stromal tumour!

Cytopathology 2022 May 16;33(3):397-401. Epub 2022 Feb 16.

Department of Pathology, Singapore General Hospital, Singapore, Singapore.

Inflammatory myofibroblastic tumours (IMT) are spindle cell neoplasms most commonly seen in the lungs, with a wide variety of less common extrapulmonary sites including the mesentery, omentum, and intrabdominal sites. On cytological evaluation, these tumours can be difficult to diagnose, given the morphological mimics of other submucosal spindle cell neoplasms, which may be compounded by the relatively small amount of tissue and the uncommon nature of the diagnosis. Immunohistochemical staining and molecular studies for the ALK gene can prove useful for diagnosing this tumour. Read More

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Jejunal gastrointestinal stromal tumour masquerading as an ovarian cancer: A case report.

Med J Malaysia 2022 Jan;77(1):125-127

Hospital Umum Sarawak, Department of surgery, Jalan Hospital Kuching, Sarawak, Malaysia.

A 60-year-old lady presented with lower abdominal discomfort and a huge palpable intra-abdominal mass for 4 months, with significant weight loss over half a year. Transvaginal ultrasonography and computed tomography (CT) abdomen showed a large right solid cystic mass likely ovarian in origin. The CA-125 was raised. Read More

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January 2022

Transvaginal excision of a rectovaginal septum GIST: a minimally invasive and safe surgical approach.

Tech Coloproctol 2022 Apr 27;26(4):315-318. Epub 2022 Jan 27.

Unit of Surgery, National Institute of Gastroenterology "Saverio de Bellis", Research Hospital, Castellana Grotte, Bari, Italy.

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Colonic gastro-intestinal stromal tumours: a rare cause of gastro-intestinal bleeding.

ANZ J Surg 2022 Jan 25. Epub 2022 Jan 25.

General Surgery Rotorua, Lakes DHB, Rotorua, New Zealand.

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January 2022

Canonical TGFβ signaling induces collective invasion in colorectal carcinogenesis through a Snail1- and Zeb1-independent partial EMT.

Oncogene 2022 03 24;41(10):1492-1506. Epub 2022 Jan 24.

Institute of Molecular Medicine and Cell Research, Faculty of Medicine, University of Freiburg, 79104, Freiburg, Germany.

Local invasion is the initial step towards metastasis, the main cause of cancer mortality. In human colorectal cancer (CRC), malignant cells predominantly invade as cohesive collectives and may undergo partial epithelial-mesenchymal transition (pEMT) at the invasive front. How this particular mode of stromal infiltration is generated is unknown. Read More

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Incidentally found primary Ewing sarcoma in the duodenum.

Indian J Pathol Microbiol 2022 Jan-Mar;65(1):206-207

Department of Pathology, Yeungnam University College of Medicine, Daegu, South Korea.

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February 2022