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BMC Gastroenterol 2022 Jan 25;22(1):32. Epub 2022 Jan 25.

Department of Surgery, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, No. 1 Shuaifuyuan, Dongcheng District, Beijing, 100730, People's Republic of China.

Background: Intestinal pseudo-obstruction (IPO) accompanied by hepatobiliary dilatation and ureterohydronephrosis is extremely rare in systemic lupus erythematosus (SLE). This triad is also called visceral muscle dysmotility syndrome (VMDS). Only 9 cases have been reported in the literature. Read More

Exp Clin Transplant 2022 02 14;20(2):209-212. Epub 2022 Jan 14.

From the Department of Gastroenterology, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisbon, Portugal.

Human herpesvirus 6 infection is common after organ transplant. Generally, infection is asymptomatic or is associated with a mild illness. However, human herpesvirus 6 infection in these patients may as well be life threatening as a result of severe end-stage organ disease. Read More

J Surg Case Rep 2021 Dec 20;2021(12):rjab554. Epub 2021 Dec 20.

Department of Surgery, Medical Academy, Hospital of Lithuanian University of Health Sciences, Kaunas, Lithuania.

Visceral myopathy is a rare bowel disease affecting peristalsis and causing pseudo-obstruction. There is no specific treatment for chronic intestinal pseudo-obstruction caused by visceral myopathy. We report a case of a 30-year-old woman with visceral myopathy who, due to unsuccessful conservative treatment, underwent surgery. Read More

Zhonghua Wei Chang Wai Ke Za Zhi 2021 Dec;24(12):1054-1057

Department of Colorectal Surgery, Changhai Hospital, Naval Medical University, Shanghai 200433, China.

Adult megacolon is a rare disease with heterogeneneous etiology. The treatment schemes of megacolon caused by different causes are also different, but surgery is the final and the most effective method. Due to the lack of early understanding of the disease, many patients have not been clearly diagnosed as adult megacolon and have not been properly treated. Read More

Children (Basel) 2021 Oct 30;8(11). Epub 2021 Oct 30.

Pediatric Surgery Department, "Vittore Buzzi" Children's Hospital, 20154 Milano, Italy.

Colonic volvulus (CV) is a rare but potentially life-threatening condition with unclear etiopathogenesis. To date, less than 80 pediatric cases have been described. Hirschsprung's disease (HD) is associated with CV in 17% of cases, representing a significant risk factor. Read More

Magy Seb 2021 Nov 25;74(4):117-121. Epub 2021 Nov 25.

1 Dél-pesti Centrumkórház - Országos Hematológiai és Infektológiai Intézet - Szent István Telephely, Sebészeti Osztály, 1097 Budapest, Nagyvárad tér 1.

Összefoglaló. Bevezetés: A colon sigmoideum diverticulosisa veleszületett vagy szerzett lehet. Az óriás vastagbél diverticulum (Giant Colonic Diverticulum, GCD), amelyet 4 cm-nél nagyobb diverticulumként definiálnak, ritka, de klinikailag fontos entitás. Read More

Exp Clin Transplant 2021 12 10;19(12):1348-1351. Epub 2021 Nov 10.

From the Department of Organ Transplantation and General Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan.

Ogilvie syndrome (acute colonic pseudo-obstruction) is a rare, acquired, life-threatening disorder for which treatment plans vary from simple observation to surgical intervention. Ogilvie syndrome has been reported in patients after renal or liver transplant, but its occurrence after simultaneous pancreas-kidney transplant is rare. Herein, we present the case of a 45-year-old female recipient of a deceased donor simultaneous pancreas-kidney transplant who developed Ogilvie syndrome 10 days after a previous fecal ileus that had resolved at posttransplant week 3. Read More

Pediatr Transplant 2022 Mar 8;26(2):e14180. Epub 2021 Nov 8.

Service de chirurgie pédiatrique viscérale, hôpital Necker - Enfants malades, Paris, France.

Chronic intestinal pseudo-obstruction (CIPO) is characterized by severe digestive +/- urinary dysmotility. If the conservative management fails, multivisceral transplantation (MVT) may be needed. However, urinary dysmotility remains after MVT and requires to continue urinary catheterizations and/or drainage. Read More

Pediatr Clin North Am 2021 12;68(6):1255-1271

Section of Pediatric Gastroenterology, Hepatology and Nutrition, Pediatric Gastroenterology and Hepatology, Neurogastroenterology and Motility Center, Yale School of Medicine, Yale University School of Medicine, Yale New Haven Children's Hospital, 333 Cedar Street, LMP 4093, PO Box 208064, New Haven, CT 06520, USA. Electronic address:

Functional and motility gastrointestinal disorders are the most common complaints to the pediatric gastroenterologist. Disorders affecting the small intestine carry a significant morbidity and mortality due to the severe limitation of therapeutic interventions available and the complications associated with such interventions. Congenital colorectal disorders are rare but also carry significant morbidity and poor quality of life plus the social stigma associated with its complications. Read More

Am Surg 2022 Mar 13;88(3):409-413. Epub 2021 Oct 13.

12328Vanderbilt University Medical Center, Department of Surgery, Division of Trauma and Critical Care, Nashville, TN, USA.

Background: Postoperative ileus (POI) is a surgical complication resulting in increased morbidity and length of stay (LOS). Usual care for POI includes bowel rest and gastric decompression. It has been questioned if methylnaltrexone (MNTX), a peripheral opioid antagonist, could be used as treatment for POI. Read More

Neurogastroenterol Motil 2022 May 16;34(5):e14259. Epub 2021 Sep 16.

Neurogastroenterology & Motility Unit, Gastroenterology Department, Great Ormond Street Hospital for Children, London, UK.

Background: Antroduodenal manometry (ADM) and histopathology are currently employed to aid the diagnosis of pediatric intestinal pseudo-obstruction (PIPO). Limited data are available on the reliability of ADM analysis and its correlation with histopathology. We aimed to develop a protocol for enhanced analysis of ADM contractile patterns, including a scoring system, and explore whether this provided better correlation with histopathology. Read More

World Neurosurg 2021 11 1;155:e612-e620. Epub 2021 Sep 1.

Department of Orthopaedic Surgery, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, California, USA.

Background: Ogilvie syndrome (OS) is a rare but serious condition seen in the postoperative period. This was an epidemiologic study using data from the National Inpatient Sample from 2005 to 2014 to look at incidence, risk factors, and outcomes associated with OS after primary spine fusion.

Methods: International Classification of Diseases, Ninth Revision codes were used to identify patients who underwent spine fusion surgery. Read More

Clin Nutr 2021 09 2;40(9):5196-5220. Epub 2021 Aug 2.

Department of Nutritional Medicine and Prevention, University of Hohenheim, Stuttgart, Germany.

Background: This practical guideline is based on the ESPEN Guidelines on Chronic Intestinal Failure in Adults.

Methodology: ESPEN guidelines have been shortened and transformed into flow charts for easier use in clinical practice. The practical guideline is dedicated to all professionals including physicians, dieticians, nutritionists, and nurses working with patients with chronic intestinal failure. Read More

J Investig Med High Impact Case Rep 2021 Jan-Dec;9:23247096211034303

Central Michigan University, Saginaw, MI, USA.

Hollow visceral myopathy (HVM) is described as impaired intestinal function and motility in the absence of mechanical obstruction. In this case report, we describe a unique case of an 18-year-old female who presented to the hospital with complaints of persistent nausea, vomiting, inability to tolerate oral feeds, and substantial weight loss for 2 months. After appropriate investigations, a diagnosis of gastroparesis was established. Read More

Sci Rep 2021 08 5;11(1):15889. Epub 2021 Aug 5.

Stem Cells and Regenerative Medicine, UCL Great Ormond Street Institute of Child Health, 30 Guilford Street, London, WC1N, UK.

Enteric neural stem cells (ENSC) have been identified as a possible treatment for enteric neuropathies. After in vivo transplantation, ENSC and their derivatives have been shown to engraft within colonic tissue, migrate and populate endogenous ganglia, and functionally integrate with the enteric nervous system. However, the mechanisms underlying the integration of donor ENSC, in recipient tissues, remain unclear. Read More

J Int Med Res 2021 Jul;49(7):3000605211032429

University Medical Centre Maribor, Maribor, Slovenia.

Sigmoid volvulus is an extremely rare cause of intestinal obstruction in pediatric patients. This condition occurs when a redundant sigmoid loop with a narrow mesenteric base of attachment to the posterior abdominal wall rotates around its mesenteric axis. This situation might result in vascular occlusion and large bowel obstruction. Read More

Palliat Support Care 2021 10;19(5):631-633

Unit for Aging Brain and Dementia, Department of Geriatric Medicine, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey.

Objective: Corticobasal syndrome (CBS) is one of an atypical parkinsonian syndromes characterized by extrapyramidal features as well as cortical involvement signs. A variety of factors may lead to delirium in older adults with chronic progressive life-limiting neurological illnesses like CBS. Ogilvie's syndrome (OS) is an acute colonic pseudo-obstruction in which abdominal distension, nausea, vomiting, and constipation can be seen. Read More

Int J Mol Sci 2021 Jun 26;22(13). Epub 2021 Jun 26.

Department of Surgery, University Hospital of Bonn, 53105 Bonn, Germany.

Interactions between the peripheral nervous system and resident macrophages (MMs) modulate intestinal homeostatic functions. Activation of β2-adrenergic receptors on MMs has been shown to reduce bacterial challenges. These MMs are also crucial for the development of bowel inflammation in postoperative ileus (POI), an iatrogenic, noninfectious inflammation-based motility disorder. Read More

Dis Colon Rectum 2021 09;64(9):1046-1057

Rutgers University, New Brunswick, New Jersey.

Braz J Anesthesiol 2021 Sep-Oct;71(5):582-584. Epub 2021 May 12.

Centro Hospitalar Tondela Viseu, EPE, Viseu, Portugal.

We report the case of a 62-year-old female who suffered from a persistent postoperative paralytic ileus following an urgent open cholecystectomy. On the fifth postoperative day we performed a bilateral Quadratus Lumborum Block (QLB) type 1 which resulted in a progressive resolution of the condition. This case report highlights that QLB is not only limited to somatic pain control, but it can also be used to alleviate visceral pain, namely in the context of paralytic ileus management in the postoperative period. Read More

J Obstet Gynaecol 2022 Jan 2;42(1):1-9. Epub 2021 May 2.

Obstetrics and Gynecology Department, Academic Hospital of Udine, Department of Medicine, University of Udine, Udine, Italy.

Acute colonic pseudo-obstruction, or Ogilvie's syndrome (OS), is a complication in gynaecology and obstetrics. Its occurrence during pregnancy is rare, redefining the therapeutic decision-making and treatment options. In this review we describe the case of a 37-year-old pregnant patient who developed OS at the 30th week of gestation. Read More

J Neurol 2022 Mar 2;269(3):1182-1194. Epub 2021 May 2.

IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy.

Objectives: This work aimed to report the demographic and clinical characteristics of two new cases with non-paraneoplastic anti-Hu-associated gut motility impairment, and perform a thorough revision covering anti-Hu-associated paraneoplastic (PGID) and non-paraneoplastic (nPGID) gastrointestinal dysmotility.

Background: Several case series have clearly established a relationship between certain type of cancers, the development of circulating anti-Hu antibodies, and the concomitant usually severe gastrointestinal dysmotility; in contrast, a few studies focused on anti-Hu-associated nPGID.

Methods: We searched for studies regarding anti-Hu-associated gastrointestinal manifestations and extracted data concerning clinical characteristics of patients, including specific demographic, oncological, neurological, gastrointestinal, histological, and treatment response features. Read More

Curr Gastroenterol Rep 2021 Apr 15;23(6). Epub 2021 Apr 15.

Division of Gastroenterology, Ann and Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

Purpose Of Review: Pediatric intestinal failure is a complex condition requiring specialized care to prevent potential complications. In this article, we review the available evidence supporting recent advances in care for children with intestinal failure.

Recent Findings: Multidisciplinary intestinal rehabilitation teams utilize medical and surgical management techniques to help patients achieve enteral autonomy (EA) while preventing and treating the complications associated with intestinal failure. Read More

BMC Surg 2021 Apr 12;21(1):191. Epub 2021 Apr 12.

Division of Surgery, Kenpoku Medical Center, Takahagi Kyodo Hospital, 1006-9, Agehocho, Kamitezuna, Takahagi, Ibaraki, Japan.

Background: Acute colonic pseudo-obstruction (ACPO) is a rare condition observed in patients with some underlying medical or surgical conditions. To the best of our knowledge, this is the first case report of a patient with ACPO development and rapid septic progression after laparoscopic inguinal hernia repair.

Case Presentation: A 78-year-old man who underwent transabdominal preperitoneal hernia repair (TAPP) for right inguinal hernia presented with difficulty in defecation and abdominal distension. Read More

Z Gastroenterol 2021 Apr 12;59(4):326-330. Epub 2021 Apr 12.

Innere Medizin, Schön Klinik Hamburg Eilbek, Hamburg, Germany.

T-lymphocytic enteral leiomyositis (T-lel) is a rare disorder causing chronic intestinal pseudo-obstruction (CIPO), with cases predominantly being reported in the field of veterinary and pediatric medicine. Here, we present a case of T-lel-associated CIPO in an adult female, who initially presented with a paralytic ileus 2 weeks after a common gastroenteritis. The histological diagnosis was established through full-thickness bowel biopsy, exhibiting a dense lymphocytic infiltrate in the lamina muscularis of the intestinal wall. Read More

Ter Arkh 2020 Dec 15;92(12):4-9. Epub 2020 Dec 15.

Loginov Moscow Clinical Scientific Center.

Chronic intestinal pseudo-obstruction a rare violation of the motor skills of the gastrointestinal complex, similar to mechanical obstruction, but without a mechanical obstacle. The development of chronic intestinal pseudo-obstruction is caused by a disturbance on the part of the smooth muscles and the nervous system of the gastrointestinal system. Common symptoms include constipation, abdominal pain, nausea, vomiting, bloating. Read More

Pan Afr Med J 2020 2;37:298. Epub 2020 Dec 2.

Internal Medicine, Corpus Christi Medical Center, Corpus Christi, United State of America and Internal Medicine, University of North Texas, Dallas, United State of America.

Since it was first documented in 1948 by Sir William Heneage Ogilvie, numerous cases of Ogilvie syndrome have been described in literature due to various medical and surgical causes. Nonetheless, only a handful of cases only have been documented due to underlying Acquired Immunodeficiency Syndrome (AIDS). A 41-year-old female was admitted with an acute abdomen secondary to partial mechanical intestinal obstruction or paralytic ileus based on signs and symptoms and Abdominal X-Ray (AXR). Read More

Nutrition 2021 06 29;86:111174. Epub 2021 Jan 29.

Department of Translational Medicine, University of Ferrara, Ferrara, Italy.

Pediatric intestinal pseudoobstruction (PIPO) is the "tip of the iceberg" of the most severe gut motility disorders. In patients with PIPO, the impairment of gastrointestinal propulsive patterns is such as to result in progressive obstructive symptoms without evidence of mechanical causes. PIPO is an important cause of intestinal failure and affects growth and pubertal development. Read More

Pediatr Blood Cancer 2021 05 3;68(5):e28926. Epub 2021 Feb 3.

Metabolic Clinic, Ruth Rappaport Children's Hospital, Rambam Health Care Campus, Haifa, Israel.

Background: Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is a progressive autosomal recessive disorder characterized by cachexia, gastrointestinal (GI) dysmotility, ptosis, peripheral neuropathy, and brain magnetic resonance imaging (MRI) white matter changes. Bi-allelic TYMP mutations lead to deficient thymidine phosphorylase (TP) activity, toxic accumulation of plasma nucleosides (thymidine and deoxyuridine), nucleotide pool imbalances, and mitochondrial DNA (mtDNA) instability. Death is mainly due to GI complications: intestinal perforation, peritonitis, and/or liver failure. Read More

Clin J Gastroenterol 2021 Apr 27;14(2):599-607. Epub 2021 Jan 27.

Colorectal Surgery Unit, Dandenong Hospital, Monash Health, 135 David Street, Dandenong, VIC, Australia.

Intestinal hypoganglionosis is a rare condition in adults. We report a case of intestinal hypoganglionosis in the mid-distal transverse colon to splenic flexure in a 65-year-old female patient presenting with altered bowel habit and abdominal distension, and reviewed the current literature on this topic. Our patient had a medical history of neurofibromatosis type 1. Read More