329 results match your criteria Intestinal Polypoid Adenomas


A histopathological study on spontaneous gastrointestinal epithelial tumors in dogs.

J Toxicol Pathol 2020 Apr 25;33(2):105-113. Epub 2020 Jan 25.

Laboratory of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan.

The present study evaluated the histopathological features, biological nature, anatomical location, sex, age and breeds of dogs affected by spontaneous gastrointestinal epithelial tumor. Biopsy samples of gastrointestinal tumors, from 95 dogs were examined and classified according to the WHO histological classification. A total of 131 samples, including 38 gastric, 13 small intestinal, and 80 large intestinal tumors were examined. Read More

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http://dx.doi.org/10.1293/tox.2019-0076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218236PMC

Synchronous colonic adenoma and intestinal marginal zone B-cell lymphoma associated with Crohn's disease: a case report and literature review.

BMC Cancer 2019 Oct 17;19(1):966. Epub 2019 Oct 17.

Department of Surgical Oncology, Mohamed I University, 30050, Oujda, Morocco.

Background: Lymphoma and dysplasia are rare complications of long-standing Crohn's disease. We report an exceptional case of a synchronous intestinal marginal zone B-cell lymphoma (MALT lymphoma) and colonic adenoma in a Crohn's disease patient.

Case Presentation: A 50-year-old male patient presented with right lower quadrant for the last 9 months. Read More

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http://dx.doi.org/10.1186/s12885-019-6224-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6796348PMC
October 2019
1 Read

Chromosome Engineering of Human Colon-Derived Organoids to Develop a Model of Traditional Serrated Adenoma.

Gastroenterology 2020 02 14;158(3):638-651.e8. Epub 2019 Oct 14.

Department of Gastroenterology, Keio University School of Medicine, Tokyo, Japan; Department of Organoid Medicine, Keio University School of Medicine, Tokyo, Japan. Electronic address:

Background & Aims: Traditional serrated adenomas (TSAs) are rare colorectal polyps with unique histologic features. Fusions in R-spondin genes have been found in TSAs, but it is not clear whether these are sufficient for TSA development, due to the lack of a chromosome engineering platform for human tissues. We studied the effects of fusions in R-spondin genes and other genetic alterations found in TSA using CRISPR-Cas9-mediated chromosome and genetic modification of human colonic organoids. Read More

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http://dx.doi.org/10.1053/j.gastro.2019.10.009DOI Listing
February 2020
1 Read

Endoscopic Assessment of the Malignant Potential of the Nonpolypoid (Flat and Depressed) Colorectal Neoplasms: Thinking Fast, and Slow.

Gastrointest Endosc Clin N Am 2019 Oct 25;29(4):613-628. Epub 2019 Jul 25.

Advanced Gastrointestinal Endoscopy, Mountain View, CA, USA; University of Indonesia, Kampus Baru UI Depok, Jawa Barat, Jakarta 16424, Indonesia. Electronic address:

Current endoscopy training methodology does not meet the learning traits, skills, and needs of the newer generation of gastroenterologists. This article provides information on assessment of the malignant potential of colorectal neoplasms. It takes a modern approach on the topic and integrates relevant information that aligns with the thinking process. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10525157193007
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http://dx.doi.org/10.1016/j.giec.2019.06.006DOI Listing
October 2019
2 Reads

Impact of linked-color imaging on colorectal adenoma detection.

Gastrointest Endosc 2019 11 11;90(5):826-834. Epub 2019 Jul 11.

Postgraduate Program in Principles of Surgery, Faculdade Evangélica do Paraná, Curitiba, PR, Brazil.

Background And Aims: Linked-color imaging (LCI) is a new technology that emphasizes changes in mucosal color by providing clearer and brighter images, thus allowing red and white areas to be visualized more clearly. We investigated whether LCI increases the detection of colorectal adenomas compared with white-light imaging (WLI) and blue-laser imaging (BLI)-bright.

Methods: Consecutive patients undergoing colonoscopy were randomized (1:1:1) into examination by WLI, BLI-bright, or LCI during withdrawal of the colonoscope. Read More

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http://dx.doi.org/10.1016/j.gie.2019.06.045DOI Listing
November 2019
6 Reads

Giant villous adenoma of rectum- what is the malignant potential and what is the optimal treatment? A case and review of literature.

World J Surg Oncol 2019 Jun 25;17(1):109. Epub 2019 Jun 25.

Department of Pathology, Maulana Azad Medical College, New Delhi, India.

Introduction: Villous adenomas are dubiously benign lesions, which are difficult to interpret because of their malignant potential. Distal villous adenomas present with bleeding or mucus discharge. Giant adenomas are not amenable for endoscopic or transanal resection. Read More

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http://dx.doi.org/10.1186/s12957-019-1650-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6593568PMC
June 2019
5 Reads

Metagenomic and metabolomic analyses reveal distinct stage-specific phenotypes of the gut microbiota in colorectal cancer.

Nat Med 2019 06 6;25(6):968-976. Epub 2019 Jun 6.

School of Life Science and Technology, Tokyo Institute of Technology, Tokyo, Japan.

In most cases of sporadic colorectal cancers, tumorigenesis is a multistep process, involving genomic alterations in parallel with morphologic changes. In addition, accumulating evidence suggests that the human gut microbiome is linked to the development of colorectal cancer. Here we performed fecal metagenomic and metabolomic studies on samples from a large cohort of 616 participants who underwent colonoscopy to assess taxonomic and functional characteristics of gut microbiota and metabolites. Read More

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http://www.nature.com/articles/s41591-019-0458-7
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http://dx.doi.org/10.1038/s41591-019-0458-7DOI Listing
June 2019
68 Reads

Giant Brunner's Gland Adenoma Presenting as Upper Gastrointestinal Bleeding in 76 Years Old Male: A Case Report.

JNMA J Nepal Med Assoc 2019 Jan-Feb;57(215):50-52

Department of Surgery, Manipal Teaching Hospital, Pokhara, Nepal.

Brunner's gland adenoma is a rare benign tumor of small bowel, often incidentally discovered during endoscopy or radiological imaging. Mostly they are asymptomatic or often present with nonspecific symptoms such as nausea, vomiting, gastrointestinal hemorrhage, iron deficiency anemia. We reported a 76 years old male case presented with chief complaints of vomiting and black tarry stool. Read More

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November 2019
7 Reads

Crypts With Corrupted Shapes in Non-polypoid Adenomas.

Anticancer Res 2019 Feb;39(2):833-838

Department of Medicine Solna, Center for Digestive Diseases, Karolinska Institute and University Hospital, Stockholm, Sweden.

Background: Colonic crypts with normal epithelial lining exhibiting corrupted shapes (NECS) have been previously found beneath the adenomatous tissue of polypoid conventional adenomas, in both rats and humans.

Aim: To assess the frequency of NECS in non-polypoid colonic flat adenomas (FAs) and lateral-spreading adenomas (LSAs).

Materials And Methods: Histological hematoxylin and eosin-stained sections from 51 non-polypoid colonic adenomas were scrutinized over a 10-mm field of vision (FOV). Read More

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http://dx.doi.org/10.21873/anticanres.13182DOI Listing
February 2019
10 Reads

The inverted appendix - a potentially problematic diagnosis: clinicopathologic analysis of 21 cases.

Histopathology 2019 May 20;74(6):853-860. Epub 2019 Mar 20.

Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Aims: Inverted appendices are rare, but have the potential to cause diagnostic confusion among endoscopists and pathologists. The aim of this study was to describe the clinicopathological features of inverted appendices seen at our institution over the last 30 years.

Methods And Results: Twenty-one inverted appendices were identified and the clinical and pathological features reviewed. Read More

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http://dx.doi.org/10.1111/his.13824DOI Listing
May 2019
5 Reads

Pyloric Gland Adenoma of Gallbladder: A Review of Diagnosis and Management.

Adv Med 2018 19;2018:7539694. Epub 2018 Dec 19.

Professor of Pathology, Director of Gastrointestinal Pathology Service, University of Miami Miller School of Medicine, 1611 NW 12 Ave Holtz Bldg. Room 2042, Miami, FL, USA.

Neoplastic polypoid mucosal lesions of the gallbladder are increasingly being reported in cholecystectomy specimens. However, due to the absence of unified terminology and reporting criteria, the body of scientific evidence on their classification, prognosis, and management is scarce and sometimes controversial. While they have different histomorphologic features (gastric foveolar, gastric pyloric gland, biliary, and intestinal), a significant immunohistochemical overlap exists which highlights their mixed cell lineage with a dominant cell type in each, establishing the subcategory. Read More

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http://dx.doi.org/10.1155/2018/7539694DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6313964PMC
December 2018
10 Reads

Intestinal-type adenocarcinoma of the vagina: clinico-pathologic features of a common tumor with a rare localization.

Pathologica 2018 Sep;110(2):92-95

Department of Medical and Surgical Sciences and Advanced Technologies, G.F. Ingrassia, Azienda Ospedaliero-Universitaria "Policlinico-Vittorio Emanuele", Anatomic Pathology Section, School of Medicine, University of Catania, Italy.

Intestinal-type adenocarcinoma is a rare primary vaginal carcinoma and considerably more uncommon than metastatic lesions which represent the most frequent malignancy at this anatomic site. Among all malignant tumors, colorectal, breast and female genital tract carcinomas have the tendency to metastasize to the vagina.

As morphologic and immunohistochemical features of intestinal-type adenocarcinoma occurring primarily in the vagina are not specific, clinical and radiologic information is crucial to exclude a metastatic lesion. Read More

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September 2018
5 Reads

Efficacy of autofluorescence imaging for flat neoplasm detection: a multicenter randomized controlled trial (A-FLAT trial).

Gastrointest Endosc 2019 03 16;89(3):460-469. Epub 2018 Nov 16.

Endoscopy Division, National Cancer Center Hospital, Tokyo, Japan.

Background And Aims: Colorectal flat (nonpolypoid) lesions can be overlooked during colonoscopy. This study evaluated the efficacy of updated autofluorescence imaging (AFI) for detecting colorectal flat neoplasms.

Methods: This was a prospective, multicenter, randomized controlled trial in 9 Japanese tertiary institutions. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00165107183328
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http://dx.doi.org/10.1016/j.gie.2018.11.012DOI Listing
March 2019
48 Reads

Mimickers of urothelial neoplasia.

Ann Diagn Pathol 2019 Feb 26;38:11-19. Epub 2018 Sep 26.

Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD, USA; Department of Urology, The Johns Hopkins Medical Institutions, Baltimore, MD, USA; Department of Oncology, The Johns Hopkins Medical Institutions, Baltimore, MD, USA. Electronic address:

Management of malignant urothelial tumors is often associated with extended costly treatments, some with significant morbidity. Advanced tumors are treated with radical cystectomy with neoadjuvant or adjuvant radiation or chemotherapy. Over and under interpretation of histological findings from biopsies and transurethral resections of urothelial lesions may either incur treatments with significant side effects or miss a possible window of cure, respectively. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2018.09.012DOI Listing
February 2019
20 Reads

Hyperplastic polyps arising in autoimmune metaplastic atrophic gastritis patients: is this a distinct clinicopathological entity?

Scand J Gastroenterol 2018 Oct - Nov;53(10-11):1186-1193. Epub 2018 Oct 24.

a Pathological Laboratory, Department of Gastroenterology , Peking University Third Hospital , Beijing , PR China.

Objectives: Gastric hyperplastic polyp (GHP) commonly arises in the abnormal surrounding mucosa, including autoimmune metaplastic atrophic gastritis (AMAG). We aimed to compare clinicopathological features in patients with GHPs associated with AMAG with those in patients with GHPs associated with non-AMAG.

Patients And Methods: A total of 1170 patients with GHP(s) were enrolled, and their clinical and pathological data were analyzed, retrospectively. Read More

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https://www.tandfonline.com/doi/full/10.1080/00365521.2018.1
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http://dx.doi.org/10.1080/00365521.2018.1514420DOI Listing
April 2019
23 Reads

Massive juvenile polyposis of the stomach in a family with SMAD4 gene mutation.

Fam Cancer 2019 04;18(2):165-172

Dipartimento di Medicina Diagnostica, Clinica e Sanità Pubblica, Università di Modena e Reggio Emilia, Policlinico, Via del Pozzo n.71, 41100, Modena, Italy.

Relatively little is known on the genotype-phenotype correlations between SMAD4 gene mutations, juvenile polyposis of the intestine and Hereditary Hemorrhagic Teleangectasia. We describe a family in which the proband (a 46-year old woman) had massive polyposis of the stomach-leading to surgery-with high-grade dysplasia at histology. Molecular analysis was carried out using Next Generation sequencing techniques with Miseq Illumina Platforms and a minimal coverage of 40 reads. Read More

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http://link.springer.com/10.1007/s10689-018-0100-8
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http://dx.doi.org/10.1007/s10689-018-0100-8DOI Listing
April 2019
31 Reads

Lipoma of the transverse colon covered by tubulovillous adenoma: a rare indication for surgical treatment.

G Chir 2018 Jan-Feb;39(1):63-66

Lipomas of the digestive tract are rare benign tumours which, in most cases, are totally asymptomatic. Because of their localization within the intestinal wall, endoscopy may be completely negative so contrast-enhanced computed tomography (CT) is very important for detecting and typing these lesions. The case of a 49-year-old man with abdominal pain is presented. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5902148PMC
http://dx.doi.org/10.11138/gchir/2018.39.1.063DOI Listing
September 2019
7 Reads

Cronkhite-Canada syndrome causing pouch outlet obstruction 5 years after roux-en-y gastric bypass.

Acta Chir Belg 2019 Feb 5;119(1):56-58. Epub 2017 Dec 5.

a Dienst Abdominale, Kinder- en Reconstructieve Heelkunde , UZA , Antwerpen , Belgium.

Objective: We present the case of a 57-year-old man with a history of Roux-en-Y gastric bypass (RYGB) and colonic polyps who presented with an upper gastrointestinal obstruction based on massive stomach polyposis in the pouch.

Methods: Two months prior to this acute admission, he had undergone resection of the gastric remnant due to massive refractory intraluminal bleeding from a polypoid mass. Ten years earlier, right colectomy was performed due to hypertrophic polyposis unsuitable for endoscopic polypectomy. Read More

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https://www.tandfonline.com/doi/full/10.1080/00015458.2017.1
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http://dx.doi.org/10.1080/00015458.2017.1411556DOI Listing
February 2019
14 Reads

Neoplastic Lesions of Gastric Adenocarcinoma and Proximal Polyposis Syndrome (GAPPS) Are Gastric Phenotype.

Am J Surg Pathol 2018 Jan;42(1):1-8

PathWest Laboratory Medicine (QE 2 Medical Centre) and University of Western Australia.

Neoplastic lesions of gastric adenocarcinoma and proximal polyposis of the stomach (GAPPS) are gastric phenotype. GAPPS was reported in 2011 as a new autosomal dominant gastric polyposis syndrome characterized by involvement of the gastric body/fundus with sparing of the antrum by multiple polyps, reported to be primarily fundic gland polyps (FGPs), with progression to dysplasia and adenocarcinoma of intestinal type. Our series consists of 51 endoscopic biopsies and 5 gastrectomy specimens from 25 patients belonging to a previously defined GAPPS family. Read More

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http://dx.doi.org/10.1097/PAS.0000000000000924DOI Listing
January 2018
36 Reads

Ex Vivo and In Vivo Noninvasive Imaging of Epidermal Growth Factor Receptor Inhibition on Colon Tumorigenesis Using Activatable Near-Infrared Fluorescent Probes.

Mol Imaging 2017 Jan-Dec;16:1536012117729044

1 Department of Cell Biology and Physiology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Background: Near-infrared fluorescence (NIRF) imaging combined with enzyme-activatable NIRF probes has yielded promising results in cancer detection.

Objective: To test whether 3-dimensional (3-D) noninvasive in vivo NIRF imaging can detect effects of epidermal growth factor receptor (EGFR) inhibitor on both polypoid and flat tumor load in azoxymethane (AOM)-induced colon tumors or tumors in Apc mice.

Methods: The AOM-injected KK-HIJ mice received EGFR inhibitor diet or chow diet. Read More

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http://dx.doi.org/10.1177/1536012117729044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5595252PMC
July 2018
44 Reads

Case of pediatric traditional serrated adenoma resected endoscopic submucosal dissection.

World J Gastroenterol 2017 Jun;23(24):4462-4466

Sonoko Kondo, Takeo Kondo, Hitoshi Okada, Takashi Kusaka, Department of Pediatrics, Faculty of Medicine, Kagawa University, Kagawa 761-0793, Japan.

Traditional serrated adenoma (TSA) is a type of serrated polyp of the colorectum and is thought to be a precancerous lesion. There are three types of serrated polyps, namely, hyperplastic polyps, sessile serrated adenomas/polyps, and TSAs. TSA is the least common of the three types and accounts for about 5% of serrated polyps. Read More

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http://dx.doi.org/10.3748/wjg.v23.i24.4462DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5487511PMC
June 2017
17 Reads

Screening and identification of a tumor specific methylation phenotype in the colorectal laterally spreading tumor.

Eur Rev Med Pharmacol Sci 2017 06;21(11):2611-2616

Department of Gastrointestinal Pancreatic Surgery, Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang, China.

Objective: We screened and identified the differential expression of the methylation phenotype in the whole genome of colorectal laterally spreading tumor (LSTs).

Materials And Methods: 3 tissue samples of colorectal polypoid adenomas (PAs), 3 tissue samples of LSTs and 3 tissue samples of colon cancer were analyzed with a high-density gene chip, and about 450,000 methylation sites were detected covering approximately 95% of the CpG islands. The Delta Data screening was taken through a cluster analysis of methylation phenotype differential expression. Read More

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June 2017
7 Reads

Epidemiological aspects of endoscopic resections of colorectal polyps in patients at an endoscopy training center in the Santos region, Brasil.

Rev Gastroenterol Peru 2017 Jan-Mar;37(1):47-52

Digestive Endoscopy Sector, Hospital Ana Costa. Santos, São Paulo, Brasil.

Introduction: Colorectal polyps are structures that project from the surface of the mucosal layer of the large intestine. They are classified as neoplastic or non-neoplastic. Early detection of pre-neoplastic lesions is important for preventing colorectal cancer. Read More

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April 2018
66 Reads

Diagnostic performance of Japan NBI Expert Team classification for differentiation among noninvasive, superficially invasive, and deeply invasive colorectal neoplasia.

Gastrointest Endosc 2017 Oct 28;86(4):700-709. Epub 2017 Feb 28.

Department of Gastroenterology and Metabolism, Hiroshima University Hospital, Hiroshima, Japan.

Backgrounds And Aims: The Japan NBI Expert Team (JNET) classification is the first universal narrow-band imaging magnifying endoscopic classification of colorectal tumors. Considering each type in this classification, the diagnostic ability of Type 2B is the weakest. Generally, clinical behavior is believed to be different in each gross type of colorectal tumor. Read More

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http://dx.doi.org/10.1016/j.gie.2017.02.018DOI Listing
October 2017
38 Reads

[Precursors of gastric cancer : Dysplasia and adenoma].

Authors:
C Langner

Pathologe 2017 Mar;38(2):67-74

Institut für Pathologie, Medizinische Universität Graz, Auenbruggerplatz 25, 8036, Graz, Österreich.

Gastric cancer develops from preneoplastic and early neoplastic precursor lesions. In particular, the intestinal type according to the Lauren classification is driven by chronic inflammation and progresses via a chronic gastritis - atrophy/metaplasia - dysplasia - carcinoma sequence. Staging of the extent of atrophy (OLGA) or intestinal metaplasia (OLGIM) enables risk stratification and determines follow-up investigations according to the management of precancerous conditions and lesions in the stomach (MAPS) international guidelines. Read More

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http://dx.doi.org/10.1007/s00292-017-0270-4DOI Listing
March 2017
22 Reads

Clinicopathologic characteristics of young patients with gallbladder cancer.

Pathol Res Pract 2017 Mar 29;213(3):189-193. Epub 2016 Dec 29.

Department of Pathology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, South Korea. Electronic address:

Gallbladder cancer is the most common biliary tract cancer and the fifth most common cancer of the digestive system. However, the clinicopathologic features of gallbladder cancer in young Korean patients have not been studied. This study included 101 consecutive cases of gallbladder cancer that underwent cholecystectomy at Kangbuk Samsung Hospital from December 1990 to March 2011. Read More

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http://dx.doi.org/10.1016/j.prp.2016.12.021DOI Listing
March 2017
30 Reads

Intussuscepting Ampullary Adenoma: An Unusual Cause of Gastric Outlet Obstruction Leading to Cavitating Lung Lesions.

Case Rep Gastroenterol 2016 Sep-Dec;10(3):545-552. Epub 2016 Oct 18.

Department of HPB Surgery, Barts and the London HPB Centre, Barts Health NHS Trust, The Royal London Hospital, London, UK.

Ampullary adenomas are a rare clinical entity, occurring at a rate of 0.04-0.12% in the general population. Read More

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http://dx.doi.org/10.1159/000450540DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5121554PMC
October 2016
67 Reads

Autoimmune metaplastic atrophic gastritis in chinese: a study of 320 patients at a large tertiary medical center.

Scand J Gastroenterol 2017 Feb 27;52(2):150-156. Epub 2016 Sep 27.

a Pathological Laboratory, Department of Gastroenterology , Beijing Key Laboratory for Helicobacter pylori Infection and Upper Gastrointestinal Diseases, Peking University Third Hospital , Beijing , PR China.

Objectives: Autoimmune metaplastic atrophic gastritis (AMAG) is an uncommon disease worldwide and may predispose to gastric carcinoid tumors or adenocarcinomas. The aims of this study were to outline the clinical characteristics of Chinese AMAG patients, including demographic pattern, hematologic features, and gastroscopic and histopathologic findings.

Patients And Methods: A total of 320 Chinese patients with AMAG, from January 2007 to December 2014, were reviewed in a regional hospital of China. Read More

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https://www.researchgate.net/publication/233825997_Review_of
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https://onlinelibrary.wiley.com/doi/full/10.1053/he.2000.598
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https://accp1.onlinelibrary.wiley.com/doi/full/10.1053/he.20
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https://www.tandfonline.com/doi/full/10.1080/00365521.2016.1
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http://dx.doi.org/10.1080/00365521.2016.1236397DOI Listing
February 2017
189 Reads

Patients with Endoscopically Visible Polypoid Adenomatous Lesions Within the Extent of Ulcerative Colitis Have an Increased Risk of Colorectal Cancer Despite Endoscopic Resection.

Dig Dis Sci 2016 10 12;61(10):3031-3036. Epub 2016 Jul 12.

Department of Gastroenterology, St George's Healthcare NHS Trust, Tooting, London, UK.

Objectives: Ulcerative colitis (UC) is associated with an increased risk of colorectal cancer (CRC). Few studies have looked at long-term outcomes of endoscopically visible adenomatous lesions removed by endoscopic resection in these patients. We aimed to assess the risk of developing CRC in UC patients with adenomatous lesions that develop within the segment of colitis compared to the remainder of an ulcerative colitis cohort. Read More

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http://dx.doi.org/10.1007/s10620-016-4246-7DOI Listing
October 2016
41 Reads

[Еxpression of claudin-1, 3, and 4 in colorectal cancer and polyps].

Arkh Patol 2016 May-Jun;78(3):11-19

Russian Medical Academy of Postgraduate Education Ministry of Health of Russia, Moscow; Lomonosov Moscow State University, Moscow, Russia.

Unlabelled: Claudins are a family of transmembrane tight junctions proteins. It is proven that claudins undergo structural and functional alteration in malignant cells. However, very few researches are pursued on this topic, the data provided by different researchers are controversial. Read More

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http://dx.doi.org/10.17116/patol201678311-19DOI Listing
February 2017
20 Reads

Heterotopic gastric mucosa in the anus and rectum: first case report of endoscopic submucosal dissection and systematic review.

Gastroenterol Rep (Oxf) 2016 Aug 21;4(3):196-205. Epub 2016 Apr 21.

Gastroenterology Clinic, Rome, Italy

Background: Heterotopic gastric mucosa (HGM) is the most reported epithelial heterotopia, but it is very rare in the rectum and anus.

Methods: The first case of an asymptomatic adult male with a large nonpolypoid HGM in the low rectum underwent complete resection by endoscopic submucosal dissection (ESD) is reported. The systematic review was based on a comprehensive search of MEDLINE, EMBASE and Google Scholar. Read More

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http://dx.doi.org/10.1093/gastro/gow006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4976682PMC
August 2016
51 Reads

Cronkhite-Canada syndrome: a rare case report and literature review.

BMC Gastroenterol 2016 Feb 25;16:23. Epub 2016 Feb 25.

Department of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, P. R. China.

Background: Cronkhite-Canada Syndrome (CCS) is a rare non-inherited disease characterized by gastrointestinal polyposis and ectodermal abnormalities, the estimated incidence is about one per million. Recognizing and curing the disorder face great challenge.

Case Presentation: This report refers to a Chinese 52 year old man with gastrointestinal symptoms and ectodermal abnormalities. Read More

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http://dx.doi.org/10.1186/s12876-016-0436-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4766628PMC
February 2016
39 Reads

CT colonography for the detection of nonpolypoid colorectal lesions A prospective series.

Ann Ital Chir 2015 ;86:532-8

Aim: To determine the diagnostic accuracy of CT-colonography (CTC) for colorectal nonpolypoid lesions.

Materials And Methods: In the period 2010-2011, 51 out of 454 patients undergoing CTC received also optical colonoscopy (OC). Three human readers with high, intermediate and low expertise interpreted the images. Read More

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September 2017
20 Reads

Endoscopic appearances of polypoid type 1 gastric microcarcinoids by narrow-band imaging: a case series in a referral center.

Eur J Gastroenterol Hepatol 2016 Apr;28(4):463-8

Departments of aMedical and Surgical Sciences and Translational Medicine bPathology cDigestive Endoscopy, Sant'Andrea Hospital, Sapienza University Rome, Italy.

Objective: Narrow-band imaging (NBI) has been associated with high accuracy for the identification of gastric malignant lesions. This study aimed to investigate for the first time the endoscopic NBI appearances of type 1 gastric carcinoids in a consecutive series of patients with atrophic gastritis.

Methods: Seven consecutive patients (five women, median age 61 years) with atrophic gastritis and polypoid type 1 gastric carcinoids were included. Read More

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http://pdfs.journals.lww.com/eurojgh/2016/04000/Endoscopic_a
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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/MEG.0000000000000566DOI Listing
April 2016
17 Reads

[Serrated lesions of the large intestine: Prevalence analysis and clinical and morphologic characteristics].

Arkh Patol 2015 Jul-Aug;77(4):24-32

Polyclinic Two, Ministry of Economic Development of Russia, Moscow.

Objective: to retrospectively estimate the prevalence of serrated lesions of the large intestine and to reveal the features of dis- tribution of serrated lesions in the previously diagnosed classical adenomas and hyperplastic polyps.

Material And Methods: A continuous sampling method was used to take biopsy specimens from the archive material of 440 polypoid lesions of the large intestine, which had entered in 2012-2013, and which were be morphologically reexamined by three experts. The mor- phological criteria for diagnosing different types of serrated lesions were taken according to the 2010 WHO classification of premalignant lesions of the large intestine and to the recommendations from an expert panel (Am J of Gastroenterology 2012). Read More

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http://dx.doi.org/10.17116/patol201577424-32DOI Listing
November 2015
11 Reads

[A case of polyp-type ampullary carcinoma-in-adenoma within the ampullary channel, displaying an intraductal growth pattern].

Nihon Shokakibyo Gakkai Zasshi 2015 Aug;112(8):1517-24

Department of Gastroenterology, Suzuka General Hospital.

A 70-year-old woman with jaundice was referred to our hospital. Obstructive jaundice caused by common bile duct (CBD) stones was diagnosed based on the results of blood tests, abdominal computed tomography, and endoscopic retrograde cholangiopancreatography. We attempted to remove the CBD stones endoscopically. Read More

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https://www.jstage.jst.go.jp/article/nisshoshi/112/8/112_151
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http://dx.doi.org/10.11405/nisshoshi.112.1517DOI Listing
August 2015
43 Reads

Clinicopathological risk factors of early carcinoma in colorectal neoplasias according to Japanese and Western criteria.

Hepatogastroenterology 2015 Jan-Feb;62(137):25-9

Background And Aims: There are discrepancies in the classification of early carcinoma in colorectal neoplasia between Japanese and Western criteria. However, no studies have investigated the clinicopathological risk factors associated with early carcinoma according to these criteria.

Methodology: We compared the clinicopathological risk factors of early carcinoma with those of dysplasia, and used multivariate analysis to elucidate the independent risk factors associated with early carcinoma. Read More

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June 2015
33 Reads

Upper gastrointestinal tract polyps: what do we know about them?

Asian Pac J Cancer Prev 2015 ;16(7):2999-3001

Department of Surgery, Istanbul Education and Research Hospital, Istanbul, Turkey E-mail :

Background: This study aimed to evaluate upper gastrointestinal polyps detected during esophago- gastroduodenoscopy tests.

Materials And Methods: We conducted a retrospective analysis on data regarding 55,987 upper gastrointestinal endoscopy tests performed at the endoscopy unit of Istanbul Education and Research Hospital between January 2006 and June 2012.

Results: A total of 66 upper gastrointestinal polyps from 59 patients were analyzed. Read More

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http://dx.doi.org/10.7314/apjcp.2015.16.7.2999DOI Listing
December 2015
57 Reads

Prevalence and characteristics of serrated lesions of the colorectum in Italy: A multicentre prospective cohort study.

Dig Liver Dis 2015 Jun 14;47(6):512-7. Epub 2015 Mar 14.

Gastroenterology Unit, Hospital Curto, ASL SAPolla, Italy.

Background: Serrated lesions are recognized as important contributors to colorectal cancer incidence. We aimed to prospectively assess the prevalence of serrated lesions and identify potential predictors of these lesions during colonoscopy in an Italian population.

Methods: Prospective cross sectional study involving 8 endoscopy units from February 1st to July 31st 2012. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15908658150023
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http://dx.doi.org/10.1016/j.dld.2015.03.005DOI Listing
June 2015
39 Reads

Non-polypoid colorectal neoplasms are no longer unique to Japan, but do not mix up flat and depressed lesions.

Authors:
Hiroshi Kashida

Dig Endosc 2015 Mar;27(3):300-2

Department of Gastroenterology and Hepatology, Kinki University Faculty of Medicine, Osaka, Japan.

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http://dx.doi.org/10.1111/den.12455DOI Listing
March 2015
17 Reads

Adenomas with high-grade dysplasia and early adenocarcinoma are more likely to be sessile in the proximal colon.

Colorectal Dis 2015 Aug;17(8):682-8

Pathology, Beth Israel Deaconess Medical and Harvard Medical School, Boston, Massachusetts, USA.

Aim: Size and the sessile morphology of an adenoma may explain why colonoscopy is less effective in preventing proximal colonic cancer than distal cancers. We wanted to determine if advanced polypoid neoplasms (APNs, i.e. Read More

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http://dx.doi.org/10.1111/codi.12911DOI Listing
August 2015
18 Reads

Sphingolipid metabolism in colorectal adenomas varies depending on histological architecture of polyps and grade of nuclear dysplasia.

Lipids 2015 Apr 17;50(4):349-58. Epub 2015 Jan 17.

Department of Physiology, Medical University of Bialystok, ul. Mickiewicza 2C, 15-222, Białystok, Poland,

Incidence of colorectal cancer (CRC) is growing worldwide. Pathogenetic mechanisms responsible for its onset and progression need further clarification. Colorectal adenomatous polyps are precancerous lesions with malignant potential dependent on histological architecture and grade of nuclear dysplasia. Read More

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http://dx.doi.org/10.1007/s11745-014-3987-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4365288PMC
April 2015
38 Reads

Vasculo-smooth muscle hamartomatous structure is linked to morphogenesis of colorectal polypoid adenoma.

Med Mol Morphol 2015 Jun 9;48(2):112-5. Epub 2014 Sep 9.

Department of Pathology and Laboratory Medicine, Hiroshima General Hospital of West Japan Railway Company, 3-1-36 Futabanosato, Higashi-ku, Hiroshima, 732-0057, Japan,

To investigate the difference of surrounding stromal structure between the polypoid and flat adenomas in the colorectum, we performed microscopic study including immunohistochemistry in a total of 32 colorectal adenomas (typical 24 polypoid and eight flat adenomas), especially focusing on vessels around muscularis mucosa. All 24 polypoid adenomas accompanied vasculo-smooth muscle hamartomatous structure in association with muscularis mucosa and submucosal vessels, whereas none of eight flat adenomas had vasculo-smooth muscle hamartomatous structure; surrounding muscularis mucosa and submucosa of the flat adenomas are identical to those of normal colorectal tissue. Vasculo-smooth muscle hamartomatous structure is linked to the morphogenesis of colorectal polypoid adenomas. Read More

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http://dx.doi.org/10.1007/s00795-014-0087-7DOI Listing
June 2015
14 Reads

Comparison of the clinicopathological features of flat and polypoid colorectal adenomas that are smaller than or equal to five millimeters.

Turk J Gastroenterol 2014 Feb;25(1):24-8

Department of Pathology, Maltepe University Faculty of Medicine, Istanbul, Turkey.

Background/aims: Colorectal flat adenomas (FAs) may represent a different histogenesis, since their malignant potential is thought to be higher than polypoid adenomas of the same size. In this study, we classified FAs of ≤5 mm into three subgroups-superficially elevated adenomas (SEAs), completely flat adenomas (CFAs), and depressed adenomas (DAs)-based on their low microscopic shapes and compared their clinicopathological features with polypoid tubular adenomas (pTAs) with the same size.

Materials And Methods: One hundred one pTAs and 46 FAs with tubular morphology with the same size (≤5 mm) were studied. Read More

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http://dx.doi.org/10.5152/tjg.2014.2698DOI Listing
February 2014
28 Reads

[The role of double-ballon enteroscopy in diagnosis and treatment of polypoid syndromes of gastrointestinal tract].

Khirurgiia (Mosk) 2014 (5):42-7

It was done 192 double-ballon enteroscopies in 141 patients at the period from March 2009 to March 2012. Epithelial benign tumors were detected in 10 (7.1%) patients with congenital polypoid syndromes. Read More

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September 2014
14 Reads

Endoscopic mucosal resection and snare polypectomy for treatment of a colorectal polypoid adenoma in a dog.

J Am Vet Med Assoc 2014 Jun;244(12):1435-40

Animal Medical Center, 510 E 62nd St, New York, NY 10065.

Case Description: An 11-year-old castrated male mixed-breed dog was examined for a 3-month history of hematochezia and tenesmus. Abdominal ultrasonography and rectal examination prior to referral had revealed a colorectal polyp, diagnosed as a benign colorectal polypoid adenoma after histologic examination of tissue samples. The patient was referred for treatment. Read More

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http://dx.doi.org/10.2460/javma.244.12.1435DOI Listing
June 2014
72 Reads

Characterization of the pathologic and endoscopic measurements of colorectal polyp sizes with a focus on sessile serrated adenoma and high-grade dysplasia.

Int J Clin Exp Pathol 2014 15;7(4):1635-43. Epub 2014 Mar 15.

Department of Pathology, University Medical Center of Princeton Plainsboro, NJ ; Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers University Piscataway, NJ ; Department of Pathology, Robert Wood Johnson Medical School, Rutgers University Piscataway, NJ ; Cancer Institute of New Jersey, Rutgers University Piscataway, NJ.

Background: The characteristics of pathologically measured (PMS) and endoscopically measured sizes (EMS) of the colorectal polyps (CRPs) is poorly understood, particularly in polypoid unremarkable mucosa (PUM), sessile serrated adenoma (SSA), and high-grade dysplasia (HGD).

Methods: To characterize the discordance and correlation between the PMS and EMS of CRPs including PUM, SSA, HGD, hyperplastic polyp (HP) and adenomas, we conducted this prospective observational study on the polyps collected between August 2012 and December 2013.

Results: PMS was significantly smaller than EMS in the 497 qualified CRPs regardless of the sites (left, transverse and right colorectum) or EMS (≥1 cm and <1 cm) subgroups. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4014244PMC
February 2015
35 Reads
3 Citations
1.783 Impact Factor

Primary intestinal-type glandular lesions of the vagina: clinical, pathologic, and immunohistochemical features of 14 cases ranging from benign polyp to adenoma to adenocarcinoma.

Am J Surg Pathol 2014 May;38(5):593-603

*Department of Pathology, University of Maryland School of Medicine, Baltimore, MD §James Homer Wright Pathology Laboratories, Massachusetts General Hospital, Harvard Medical School, Boston, MA †Department of Pathology, Royal Group of Hospitals Trust, Belfast, Northern Ireland ‡Department of Pathology, Vancouver General Hospital, University of British Columbia, Vancouver, BC, Canada.

Primary intestinal-type glandular lesions of the vagina are rare. We report a series of 14 lesions, including 1 intestinal-type polyp without neoplastic features, 3 adenomas (2 with high-grade dysplasia), and 10 adenocarcinomas. Patients ranged in age from 20 to 86 years (mean 60 y) and presented with vaginal bleeding or a mass. Read More

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http://dx.doi.org/10.1097/PAS.0000000000000157DOI Listing
May 2014
24 Reads

Pushing the limits of local excision for rectal cancer: transanal minimally invasive surgery for an upper rectal/rectosigmoid lesion.

Ann Surg Oncol 2014 May 10;21(5):1631. Epub 2014 Jan 10.

Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX, USA.

Background: Transanal minimally invasive surgery (TAMIS) is an evolving technique for the local excision of early rectal cancers,1 particularly for mid-rectal lesions. The approach to upper rectal lesions is significantly more challenging and prone to complications. We demonstrate TAMIS for an upper rectal/rectosigmoid lesion, with transanal repair of an intraoperative rectal/rectosigmoid perforation. Read More

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http://dx.doi.org/10.1245/s10434-013-3457-9DOI Listing
May 2014
15 Reads

[Brunner's gland adenoma: a rare tumor as cause of pyloric syndrome in an AIDS patient].

Acta Gastroenterol Latinoam 2014 ;44(3):260-4

Brunner's gland adenoma is a rare neoplasm that accounts for only the 0.008% of all benign duodenal tumors. Here we describe the case ofan HIV-seropositive man who developed a severe pyloric stenosis due to a Brunner's adenoma of the bulb and the first duodenal portion. Read More

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March 2016
23 Reads