344 results match your criteria Intestinal Polypoid Adenomas

Solitary gastric Peutz-Jeghers polyp: a case report.

Pan Afr Med J 2022 24;41:65. Epub 2022 Jan 24.

Department of Gastroenterology, Mohamed Tahar Maamouri Hospital, Nabeul, Tunisia.

Peutz-Jeghers syndrome is an inherited condition that is characterized by mucocutaneous pigmentation and hamartomatous polyposis in the gastrointestinal tract. It increases significantly the risk for developing of several cancers such as breast, colon, rectum, pancreas and stomach. Solitary Peutz-Jeghers polyp is defined as a unique hamartomatous polyp having the same histological features as Peutz-Jeghers syndrome polyps without associated intestinal polyposis, mucocutaneous pigmentation and family history of Peutz-Jeghers syndrome. Read More

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A Rare Collision Tumor: Adenocarcinoma in the Ampulla of Vater and Neuroendocrine Tumor in the Lower Part of the Common Bile Duct.

Cureus 2021 Jun 24;13(6):e15882. Epub 2021 Jun 24.

Diagnostic Pathology Clinic, Pathos Tsutsumi, Inazawa, JPN.

In the biliary tree, only three cases of neuroendocrine tumor (NET) synchronous with adenocarcinoma have been reported so far. We experienced a case of NET, grade 2 (G2), of the common bile duct associated with adenocarcinoma of the ampulla of Vater (AoV). A Japanese man at his 60's visited a local doctor, and obstructive jaundice was pointed out. Read More

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Mixed Intraepithelial Neoplasia-Well-Differentiated Neuroendocrine Tumor of the Gallbladder: A Hitherto Unreported Combination.

Int J Surg Pathol 2021 Sep 9;29(6):685-689. Epub 2021 Jan 9.

H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA.

Adenocarcinomas and noninvasive intraepithelial neoplasms (either polypoid or flat) are the most common gallbladder tumors; however, neuroendocrine neoplasms (NENs) can also occur. The majority of NENs are represented by neuroendocrine carcinomas (NECs), while neuroendocrine tumors (NETs) are extremely rare in this location. Occasionally, NEN may present as a part of a mixed neoplasm, with a coexisting non-neuroendocrine component. Read More

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September 2021

Tumour-like lesions of the urinary bladder.

Pathology 2021 Jan 15;53(1):44-55. Epub 2020 Oct 15.

Department of Oncology-Pathology, Karolinska Institute, Stockholm, Sweden.

There are a number of benign epithelial proliferations in the bladder that may be difficult to distinguish from carcinomas, including urothelial carcinoma and its variants, squamous cell carcinoma and adenocarcinoma. If misdiagnosed, there is the potential for over treatment, with its attendant risk of complications, as well as errors relating to prognostic assessment. In the case of the misdiagnosis of high grade proliferative lesions that mimic invasive carcinoma, unnecessary radical surgery, chemotherapy and radiotherapy may result. Read More

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January 2021

Evaluation of recurrence and surgical complementation rates after endoscopic resection of large colorectal non-pedunculated lesions.

Rev Esp Enferm Dig 2020 Dec;112(12):898-902

Endoscopy, Hospital Sirio Libanes, Brasil.

Background And Aim: the process that leads to the development of colorectal cancer takes many years and most tumors originate from polyps and non-polypoid lesions. Techniques of endoscopic resection are surgical treatment options, even in case of large lesions or with initial invasion. This study aimed to evaluate the recurrence and surgical complementation rates after endoscopic resection of large colorectal non-pedunculated lesions. Read More

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December 2020

Serrated Lesions in Inflammatory Bowel Disease: Genotype-Phenotype Correlation.

Int J Surg Pathol 2021 Feb 8;29(1):46-53. Epub 2020 Oct 8.

Medical University of Graz, Graz, Austria.

Background: Patients with inflammatory bowel disease (IBD) and hyperplastic/serrated polyposis have an increased risk of colorectal cancer. The aim of our study was to elucidate the nature of serrated lesions in IBD patients.

Materials And Methods: Sixty-five lesions with serrated morphology were analyzed in 39 adult IBD patients. Read More

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February 2021

A histopathological study on spontaneous gastrointestinal epithelial tumors in dogs.

J Toxicol Pathol 2020 Apr 25;33(2):105-113. Epub 2020 Jan 25.

Laboratory of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan.

The present study evaluated the histopathological features, biological nature, anatomical location, sex, age and breeds of dogs affected by spontaneous gastrointestinal epithelial tumor. Biopsy samples of gastrointestinal tumors, from 95 dogs were examined and classified according to the WHO histological classification. A total of 131 samples, including 38 gastric, 13 small intestinal, and 80 large intestinal tumors were examined. Read More

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Lymphocytic colitis pattern of injury presenting as endoscopic polyps: a case series.

Hum Pathol 2020 07 5;101:10-17. Epub 2020 May 5.

Pathology and Laboratory Medicine, Albany Medical Center, Albany, NY 12208, USA. Electronic address:

Lymphocytic colitis (LC) is characterized by chronic watery diarrhea and unremarkable endoscopic findings. Only one case of LC presenting as multiple colonic polyps has been reported. We report a case series of histologic LC pattern of injury (LCPI), presenting as endoscopic polyps, and compare them with typical LC cases. Read More

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Revisiting the distinct histomorphologic features of inflammatory bowel disease-associated neoplastic precursor lesions in the SCENIC and post-DALM Era.

Hum Pathol 2020 06 5;100:24-37. Epub 2020 May 5.

Division of Gastroenterology, University of Washington School of Medicine, Seattle, 98195, USA.

Distinct histomorphologic features of colitis-associated dysplasia (CAD) or neoplastic precursors in inflammatory bowel disease (IBD) have never been clearly identified. In this study, we tried to further explore the differentiating morphologic features of CAD by retrospectively reviewing the lesions that were clearly associated with carcinomas (carcinoma-related lesions) and by comparing between endoscopically nonpolypoid (non-adenoma-like) lesions and polypoid (adenoma-like) lesions and sporadic conventional adenomas found in the noncolitic mucosa and in patients without IBD. Our study results have revealed that (1) precursor lesions related to IBD-associated colorectal carcinomas were almost always nonpolypoid in macroscopic/endoscopic appearance; (2) nearly half of the carcinoma-related lesions and nonpolypoid lesions were similarly nonadenomatous (nonconventional) lesions, largely serrated type, with no or only mild/focal adenomatous dysplasia, and commonly had mixed adenomatous and nonadenomatous features; (3) carcinoma-related and nonpolypoid adenomatous dysplastic lesions frequently showed some peculiar histocytologic features that we observed and described for the first time, including mixed features of inflammatory pseudopolyps or granulation tissue, pleomorphic and disarrayed nuclei, micropapillary or hobnailing surface epithelial cells, and microvesicular or bubbling cytoplasm of dysplastic cells; and (4) polypoid lesions in the colitic mucosa were identical to sporadic adenomas in the noninflamed mucosa and in patients without IBD, and they lacked the aforementioned features. Read More

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Silymarin, boswellic acid and curcumin enriched dietetic formulation reduces the growth of inherited intestinal polyps in an animal model.

World J Gastroenterol 2020 Apr;26(14):1601-1612

Gastroenterology Section, Department of Emergency and Organ Transplantation, University of Bari, Bari 70124, Italy.

Background: Some substances of plant origin have been reported to exert an effect in reducing intestinal neoplasm development, especially in animal models. Adenomatous polyposis coli multiple intestinal neoplasia - Apc is the most studied murine model of genetic intestinal carcinogenesis.

Aim: To assess whether an enriched nutritional formulation (silymarin, boswellic acid and curcumin) with proven and anti-carcinogenetic properties may prevent inherited intestinal cancer in animal model. Read More

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Duodenal neoplasms of gastric phenotype: reports of two cases and a brief review of literature.

Xiaojuan Zheng

Eur J Cancer Prev 2020 05;29(3):210-214

Department of endoscopy, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Duodenal neoplasms of gastric phenotype are uncommon epithelial neoplasms. Pyloric gland adenomas should be recognized as neoplasms with risk for transformation into invasive adenocarcinoma (). Here we report the case histories of two male patients, who presented with duodenal polypoid lesion. Read More

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Polypoid disease of colon in children.

Tutku Soyer

Pediatr Surg Int 2020 Apr 21;36(4):447-455. Epub 2020 Jan 21.

Department of Paediatric Surgery, Hacettepe University Faculty of Medicine, Ankara, Turkey.

Polyps in gastrointestinal tract are mostly benign and result from hamartomas or lymphoid hyperplasia of submucosa. They usually occur as isolated lesions in children and are referred to as juvenile polyps. Multiple polyps with inherited origin are called polyposis and can be seen as a part of the syndrome. Read More

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Robotic colonoscopy: efficacy, tolerability and safety. Preliminary clinical results from a pilot study.

Surg Endosc 2020 03 13;34(3):1442-1450. Epub 2020 Jan 13.

Department of Translational and Precision Medicine, Sapienza University, Rome, Italy.

Background: Robotic colonoscopy (RC) is a pneumatically-driven self-propelling platform (Endotics System®) able to investigate the colon, in order to reduce pain and discomfort.

Aims: (1) to describe the progress in gaining experience and skills of a trainee in RC; (2) to show the clinical outcomes of RC.

Methods: Pilot study. Read More

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Detection of colonic neoplasia in vivo using near-infrared-labeled peptide targeting cMet.

Sci Rep 2019 11 29;9(1):17917. Epub 2019 Nov 29.

Division of Gastroenterology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.

White light colonoscopy is widely used to detect colorectal polyps, but flat and depressed lesions are often missed. Here, we report a molecular imaging strategy to potentially improve diagnostic performance by developing a fluorescently-labeled peptide specific for cMet. This 7mer is conjugated to Cy5. Read More

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November 2019

Endoscopic mucosal resection is effective for laterally spreading lesions at the anorectal junction.

Gut 2020 04 12;69(4):673-680. Epub 2019 Nov 12.

Department of Gastroenterology and Hepatology, Westmead Hospital, Sydney, New South Wales, Australia

Objective: The optimal approach for removing large laterally spreading lesions at the anorectal junction (ARJ-LSLs) is unknown. Endoscopic mucosal resection (EMR) is a definitive therapy for colorectal LSLs. It is unclear whether it is an effective modality for ARJ-LSLs. Read More

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Synchronous colonic adenoma and intestinal marginal zone B-cell lymphoma associated with Crohn's disease: a case report and literature review.

BMC Cancer 2019 Oct 17;19(1):966. Epub 2019 Oct 17.

Department of Surgical Oncology, Mohamed I University, 30050, Oujda, Morocco.

Background: Lymphoma and dysplasia are rare complications of long-standing Crohn's disease. We report an exceptional case of a synchronous intestinal marginal zone B-cell lymphoma (MALT lymphoma) and colonic adenoma in a Crohn's disease patient.

Case Presentation: A 50-year-old male patient presented with right lower quadrant for the last 9 months. Read More

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October 2019

Chromosome Engineering of Human Colon-Derived Organoids to Develop a Model of Traditional Serrated Adenoma.

Gastroenterology 2020 02 14;158(3):638-651.e8. Epub 2019 Oct 14.

Department of Gastroenterology, Keio University School of Medicine, Tokyo, Japan; Department of Organoid Medicine, Keio University School of Medicine, Tokyo, Japan. Electronic address:

Background & Aims: Traditional serrated adenomas (TSAs) are rare colorectal polyps with unique histologic features. Fusions in R-spondin genes have been found in TSAs, but it is not clear whether these are sufficient for TSA development, due to the lack of a chromosome engineering platform for human tissues. We studied the effects of fusions in R-spondin genes and other genetic alterations found in TSA using CRISPR-Cas9-mediated chromosome and genetic modification of human colonic organoids. Read More

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February 2020

Colon Capsule Endoscopy versus CT Colonography in Patients with Large Non-Polypoid Tumours: A Multicentre Prospective Comparative Study (4CN Study).

Digestion 2020 1;101(5):615-623. Epub 2019 Oct 1.

Department of Coloproctology, Aizu Medical Center, Fukushima Medical University, Aizuwakamatsu, Fukushima, Japan,

Background/aims: Non-polypoid colon lesions compared with polypoid lesions has a high malignant potential. The diagnostic performance of colon capsule endoscopy (CCE) and CT colonography (CTC) for large colorectal non-polypoid tumours, that is, laterally spreading tumours is still unclear. The aim of this study is to evaluate the performance of CCE and CTC for the diagnosis of large non-polypoid tumours. Read More

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Endoscopic Assessment of the Malignant Potential of the Nonpolypoid (Flat and Depressed) Colorectal Neoplasms: Thinking Fast, and Slow.

Gastrointest Endosc Clin N Am 2019 Oct 25;29(4):613-628. Epub 2019 Jul 25.

Advanced Gastrointestinal Endoscopy, Mountain View, CA, USA; University of Indonesia, Kampus Baru UI Depok, Jawa Barat, Jakarta 16424, Indonesia. Electronic address:

Current endoscopy training methodology does not meet the learning traits, skills, and needs of the newer generation of gastroenterologists. This article provides information on assessment of the malignant potential of colorectal neoplasms. It takes a modern approach on the topic and integrates relevant information that aligns with the thinking process. Read More

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October 2019

Impact of linked-color imaging on colorectal adenoma detection.

Gastrointest Endosc 2019 11 11;90(5):826-834. Epub 2019 Jul 11.

Postgraduate Program in Principles of Surgery, Faculdade Evangélica do Paraná, Curitiba, PR, Brazil.

Background And Aims: Linked-color imaging (LCI) is a new technology that emphasizes changes in mucosal color by providing clearer and brighter images, thus allowing red and white areas to be visualized more clearly. We investigated whether LCI increases the detection of colorectal adenomas compared with white-light imaging (WLI) and blue-laser imaging (BLI)-bright.

Methods: Consecutive patients undergoing colonoscopy were randomized (1:1:1) into examination by WLI, BLI-bright, or LCI during withdrawal of the colonoscope. Read More

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November 2019

Giant villous adenoma of rectum- what is the malignant potential and what is the optimal treatment? A case and review of literature.

World J Surg Oncol 2019 Jun 25;17(1):109. Epub 2019 Jun 25.

Department of Pathology, Maulana Azad Medical College, New Delhi, India.

Introduction: Villous adenomas are dubiously benign lesions, which are difficult to interpret because of their malignant potential. Distal villous adenomas present with bleeding or mucus discharge. Giant adenomas are not amenable for endoscopic or transanal resection. Read More

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Metagenomic and metabolomic analyses reveal distinct stage-specific phenotypes of the gut microbiota in colorectal cancer.

Nat Med 2019 06 6;25(6):968-976. Epub 2019 Jun 6.

School of Life Science and Technology, Tokyo Institute of Technology, Tokyo, Japan.

In most cases of sporadic colorectal cancers, tumorigenesis is a multistep process, involving genomic alterations in parallel with morphologic changes. In addition, accumulating evidence suggests that the human gut microbiome is linked to the development of colorectal cancer. Here we performed fecal metagenomic and metabolomic studies on samples from a large cohort of 616 participants who underwent colonoscopy to assess taxonomic and functional characteristics of gut microbiota and metabolites. Read More

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Giant Brunner's Gland Adenoma Presenting as Upper Gastrointestinal Bleeding in 76 Years Old Male: A Case Report.

JNMA J Nepal Med Assoc 2019 Jan-Feb;57(215):50-52

Department of Surgery, Manipal Teaching Hospital, Pokhara, Nepal.

Brunner's gland adenoma is a rare benign tumor of small bowel, often incidentally discovered during endoscopy or radiological imaging. Mostly they are asymptomatic or often present with nonspecific symptoms such as nausea, vomiting, gastrointestinal hemorrhage, iron deficiency anemia. We reported a 76 years old male case presented with chief complaints of vomiting and black tarry stool. Read More

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November 2019

Crypts With Corrupted Shapes in Non-polypoid Adenomas.

Anticancer Res 2019 Feb;39(2):833-838

Department of Medicine Solna, Center for Digestive Diseases, Karolinska Institute and University Hospital, Stockholm, Sweden.

Background: Colonic crypts with normal epithelial lining exhibiting corrupted shapes (NECS) have been previously found beneath the adenomatous tissue of polypoid conventional adenomas, in both rats and humans.

Aim: To assess the frequency of NECS in non-polypoid colonic flat adenomas (FAs) and lateral-spreading adenomas (LSAs).

Materials And Methods: Histological hematoxylin and eosin-stained sections from 51 non-polypoid colonic adenomas were scrutinized over a 10-mm field of vision (FOV). Read More

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February 2019

The inverted appendix - a potentially problematic diagnosis: clinicopathologic analysis of 21 cases.

Histopathology 2019 May 20;74(6):853-860. Epub 2019 Mar 20.

Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Aims: Inverted appendices are rare, but have the potential to cause diagnostic confusion among endoscopists and pathologists. The aim of this study was to describe the clinicopathological features of inverted appendices seen at our institution over the last 30 years.

Methods And Results: Twenty-one inverted appendices were identified and the clinical and pathological features reviewed. Read More

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Pyloric Gland Adenoma of Gallbladder: A Review of Diagnosis and Management.

Adv Med 2018 19;2018:7539694. Epub 2018 Dec 19.

Professor of Pathology, Director of Gastrointestinal Pathology Service, University of Miami Miller School of Medicine, 1611 NW 12 Ave Holtz Bldg. Room 2042, Miami, FL, USA.

Neoplastic polypoid mucosal lesions of the gallbladder are increasingly being reported in cholecystectomy specimens. However, due to the absence of unified terminology and reporting criteria, the body of scientific evidence on their classification, prognosis, and management is scarce and sometimes controversial. While they have different histomorphologic features (gastric foveolar, gastric pyloric gland, biliary, and intestinal), a significant immunohistochemical overlap exists which highlights their mixed cell lineage with a dominant cell type in each, establishing the subcategory. Read More

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December 2018

Intestinal-type adenocarcinoma of the vagina: clinico-pathologic features of a common tumor with a rare localization.

Pathologica 2018 Sep;110(2):92-95

Department of Medical and Surgical Sciences and Advanced Technologies, G.F. Ingrassia, Azienda Ospedaliero-Universitaria "Policlinico-Vittorio Emanuele", Anatomic Pathology Section, School of Medicine, University of Catania, Italy.

Intestinal-type adenocarcinoma is a rare primary vaginal carcinoma and considerably more uncommon than metastatic lesions which represent the most frequent malignancy at this anatomic site. Among all malignant tumors, colorectal, breast and female genital tract carcinomas have the tendency to metastasize to the vagina.

As morphologic and immunohistochemical features of intestinal-type adenocarcinoma occurring primarily in the vagina are not specific, clinical and radiologic information is crucial to exclude a metastatic lesion. Read More

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September 2018

Efficacy of autofluorescence imaging for flat neoplasm detection: a multicenter randomized controlled trial (A-FLAT trial).

Gastrointest Endosc 2019 03 16;89(3):460-469. Epub 2018 Nov 16.

Endoscopy Division, National Cancer Center Hospital, Tokyo, Japan.

Background And Aims: Colorectal flat (nonpolypoid) lesions can be overlooked during colonoscopy. This study evaluated the efficacy of updated autofluorescence imaging (AFI) for detecting colorectal flat neoplasms.

Methods: This was a prospective, multicenter, randomized controlled trial in 9 Japanese tertiary institutions. Read More

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Mimickers of urothelial neoplasia.

Ann Diagn Pathol 2019 Feb 26;38:11-19. Epub 2018 Sep 26.

Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD, USA; Department of Urology, The Johns Hopkins Medical Institutions, Baltimore, MD, USA; Department of Oncology, The Johns Hopkins Medical Institutions, Baltimore, MD, USA. Electronic address:

Management of malignant urothelial tumors is often associated with extended costly treatments, some with significant morbidity. Advanced tumors are treated with radical cystectomy with neoadjuvant or adjuvant radiation or chemotherapy. Over and under interpretation of histological findings from biopsies and transurethral resections of urothelial lesions may either incur treatments with significant side effects or miss a possible window of cure, respectively. Read More

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February 2019

Hyperplastic polyps arising in autoimmune metaplastic atrophic gastritis patients: is this a distinct clinicopathological entity?

Scand J Gastroenterol 2018 Oct - Nov;53(10-11):1186-1193. Epub 2018 Oct 24.

a Pathological Laboratory, Department of Gastroenterology , Peking University Third Hospital , Beijing , PR China.

Objectives: Gastric hyperplastic polyp (GHP) commonly arises in the abnormal surrounding mucosa, including autoimmune metaplastic atrophic gastritis (AMAG). We aimed to compare clinicopathological features in patients with GHPs associated with AMAG with those in patients with GHPs associated with non-AMAG.

Patients And Methods: A total of 1170 patients with GHP(s) were enrolled, and their clinical and pathological data were analyzed, retrospectively. Read More

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