18,489 results match your criteria Intestinal Perforation

The Test of Infant Motor Performance (TIMP) in very low birth weight infants and outcome at two years of age.

J Perinatol 2021 Jun 14. Epub 2021 Jun 14.

Department of Child Development, KK Women's and Children's Hospital, Singapore, Singapore.

Objective: To evaluate TIMP in preterm very low birth weight (VLBW) infants, analyze risk factors, for atypical TIMP (aTIMP) scores, and explore TIMP's predictive relationship with Bayley-III at 2 years.

Method: A prospective study of 288 VLBW infants, with TIMP assessment between 34 weeks postmenstrual age and 16 weeks age, corrected for prematurity.

Result: aTIMP scores were observed in 58/288(20%) infants, whose mean birth weight (BW) and gestational age were 1122 ± 257 g and 29. Read More

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Whole jejunoileal diverticulosis with recurrent inflammation and perforation: A case report.

Int J Surg Case Rep 2021 May 27;84:106020. Epub 2021 May 27.

Department of Surgery, Hoshigaoka Medical Center, 4-8-1 Hoshigaoka, Hirakata, Osaka, Japan. Electronic address:

Introduction: Jejunoileal diverticulitis is uncommon and poorly understood. We report a case of whole jejunoileal diverticulosis with recurrent inflammation and perforation.

Case Presentation: A 72-year-old man with hemodialysis presented with fever and abdominal pain. Read More

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Current status of surgical treatment of Boerhaave's syndrome.

Esophagus 2021 Jun 11. Epub 2021 Jun 11.

Department of Frontier Surgery, Chiba University Graduate School of Medicine, Chiba, Japan.

Background: Surgical treatment is usually required for Boerhaave's syndrome (post-emetic esophageal perforation), and the technique should be chosen based on the local infection status and patient's general condition. This study was performed to examine the current status of surgical treatment of Boerhaave's syndrome in Japan.

Methods: Ninety-five patients with Boerhaave's syndrome who underwent surgical treatment from January 2010 to December 2015, obtained from a national survey were retrospectively analyzed. Read More

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[Another causes for acute abdominal pain: Intestinal perforation due to fish bone].

Rev Esp Geriatr Gerontol 2021 Jun 7. Epub 2021 Jun 7.

Servicio de Geriatría, Complejo Hospitalario Universitario de Albacete, Albacete, España.

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[Effects of resveratrol-mediated inhibition of NOD-like receptor protein 3 inflammasomevia activating silent information regulator 1 on the injury of intestinal mucosal barrier function after sepsis].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2021 May;33(5):535-540

Department of Critical Care Medicine, the First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, Xinjiang Uygur Autonomous Region, China. Corresponding author: Yu Xiangyou, Email:

Objective: To explore whether resveratrol (RSV) could activate silent information regulator 1 (SIRT1) to regulate the activation of NOD-like receptor protein 3 (NLRP3) inflammasome in sepsis induced intestinal injury model, and then reduce intestinal inflammation and cell apoptosis, so as to play a protective role in intestinal barrier function.

Methods: (1) In vitro experiment: human Colorectal adenocarcinoma cells (Caco-2) were cultured, which were divided into normal group (normal culture on complete medium for 48 hours), lipopolysaccharide (LPS) group (normal culture on complete medium for 24 hours, then LPS containing 2 mg/L complete medium intervention for 6 hours), RSV low, medium and high concentration groups and SIRT1 inhibitor (EX-527) group (complete medium normal culture for 24 hours, LPS containing 2 mg/L complete medium intervention for 6 hours, followed by RSV 10, 20, 40 μmol/L or EX-527 10 μmol/L intervention for 6 hours, respectively). The levels of tumor necrosis factor-α (TNF-α) and interleukins (IL-6, IL-18, IL-1β) in the cell supernatant were determined by enzyme linked immunosorbent assay (ELISA). Read More

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Differential diagnosis of the association of gastrointestinal symptoms and ST segment elevation, in the absence of chest pain.

Oscar M P Jolobe

Am J Emerg Med 2021 Jun 4;49:137-141. Epub 2021 Jun 4.

British Medical Association, Flat 6 Souchay Court, 1 Clothorn Road, Manchester M20 6BR, United Kingdom. Electronic address:

This is a review of the underlying causes of the association of ST segment elevation and gastrointestinal symptoms such as abdominal pain, nausea, vomiting, and anorexia, in patients who do not have chest pain. The review was based on anecdotal reports in Googlescholar and Pubmed using the search terms, abdominal pain, nausea, vomiting, anorexia, ST elevation, myocardial infarction, and Takotsubo cardiomyopathy. Those patients who did not have acute myocardial infarction as the cause of the association of ST segment elevation and gastrointestinal symptoms were compared with counterparts with similar symptoms who had well authenticated acute myocardial infarction or Takotsubo cardiomyopathy as the underlying cause of ST segment elevation. Read More

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Neurodevelopmental outcome of very preterm infants with gastrointestinal tract perforations does not differ compared to controls.

Wien Klin Wochenschr 2021 Jun 10. Epub 2021 Jun 10.

Research Unit for Neonatal Infectious Diseases and Epidemiology, Medical University of Graz, Auenbruggerplatz 34/2, 8036, Graz, Austria.

Purpose: To evaluate gastrointestinal tract (GIT) perforations in very low birth weight infants and the effects on neurodevelopmental outcome.

Methods: Between 2000 and 2017 all cases with GIT perforation were analyzed regarding causes, associated morbidities and neurodevelopmental outcome and compared with matched (gestational age, birth weight, gender, year of birth) by 1:2 controls.

Results: The incidence of GIT perforation was 2. Read More

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Enhanced Recovery After Surgery Protocol in Emergency Laparotomy: A Randomized Control Study.

Surg J (N Y) 2021 Apr 3;7(2):e92-e99. Epub 2021 Jun 3.

Department of Anesthesiology, All India Institute of Medical, Sciences, Rishikesh, Uttarakhand, India.

 There is established evidence on the role of enhanced recovery after surgery (ERAS) protocols in elective surgeries but its effectiveness in emergency surgeries has been nominally studied. We aimed at studying the feasibility and effectiveness of ERAS protocols in patients undergoing emergency abdominal surgery for intestinal perforation and small bowel obstruction and compare their surgical outcomes with conventional care.  This prospective randomized study was performed for a period of 16 months. Read More

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Anastomosis near to the ileocecal valve in neonates with focal intestinal perforation, is it safe.

J Matern Fetal Neonatal Med 2021 Jun 6:1-4. Epub 2021 Jun 6.

Neonatal Surgery Unit, Pediatric Surgery Division, Vall d'Hebron University Hospital, Barcelona, Spain.

Background: Anastomosis near the ileocecal valve (ICV) are controversial due to the increased pressure on the suture; in this situation, the valve could be removed at a first stage or at the moment of stoma closure. However, preservation of the ICV has proved important benefits in the long term. The aim of this study is to evaluate its feasibility in neonates with focal intestinal perforation (FIP). Read More

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Endoscopic Treatment of Iatrogenic Perforation of Sigmoid Diverticulum: A Case Report of Multidisciplinary Management.

Clin Endosc 2021 Jun 7. Epub 2021 Jun 7.

Department of Surgical, Oncological and Oral Science, Palermo University Hospital, Palermo, Italy.

Iatrogenic perforations are severe complications of gastrointestinal endoscopy; therefore, their management should be adequately planned. A 77-year-old man with a history of diverticulosis underwent a colonoscopy for anemia. During the procedure, an iatrogenic perforation occurred suddenly in the sigmoid colon, near a severe angle among the numerous diverticula. Read More

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Multiple thrombosis associated with Cytomegalovirus enterocolitis in an immunocompetent patient: a case report.

BMC Infect Dis 2021 Jun 5;21(1):530. Epub 2021 Jun 5.

Department of Internal Medicine, Hyogo Prefectural Tamba Medical Center, 2002-7 Iso, Hikami-cho, Tamba, 669-3495, Japan.

Background: Cytomegalovirus (CMV) is reported to have thrombogenic characteristics that activate factor X in vitro and stimulate the production of factor VIII and von Willebrand factor (vWF). Thrombosis associated with CMV infection is prevalent among immunocompromised patients and predominantly presents as a solitary large thrombus in the deep vein, pulmonary artery, splanchnic arteriovenous ducts, or other similar sites. Multiple thrombi, however, are rarely observed in such cases. Read More

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Duodenal perforation as a postoperative complication after ventriculoperitoneal shunt: A case report.

Int J Surg Case Rep 2021 May 29;83:106059. Epub 2021 May 29.

Department of Surgery, Hanoi Medical University, Hanoi, Viet Nam. Electronic address:

Introduction And Importance: Ventriculoperitoneal shunt (VP shunt) is the one of the most common and important tools for the treatment of hydrocephalus. It requires simple technique and demonstrates effectiveness in treating hydrocephalus. However, many complications have been reported such as infection, valve obstruction, valve dysfunction and abdominal complications. Read More

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Chronic intentional chicken bone ingestion mimicking inflammatory bowel disease.

BMJ Case Rep 2021 Jun 4;14(6). Epub 2021 Jun 4.

Internal Medicine, Naval Medical Center Portsmouth, Portsmouth, Virginia, USA.

Ingestion of food by-products, such as peach pits, chicken bones and fish bones, may lead to intestinal complications. The ingestion of the foreign body is often acute and non-intentional. Acute and life-threatening complications include intestinal perforation or obstruction. Read More

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The "misfortune" of being a COVID-19 negative patient during the coronavirus pandemic.

J BUON 2021 Mar-Apr;26(2):303-305

4th Department of Surgery, Medical School, University of Athens, "Attikon" University Hospital, Athens, Greece.

COVID-19 pandemic has obviously affected patients' behavior towards seeking medical help as well as physicians' decision in the management of emergencies. Our recent experience as surgeons at a COVID-19 referral hospital revealed cases which share an alerting characteristic: the delay in appropriate management. Unfortunately for COVID-19 negative patients a "coronacentric" health system has been adopted. Read More

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Primary Gastrointestinal T/NK Cell Lymphoma.

Cancers (Basel) 2021 May 29;13(11). Epub 2021 May 29.

Department of Pathology, Severance Hospital, Yonsei University College of Medicine, Seoul 03722, Korea.

Primary gastrointestinal T/NK cell lymphoma (GI-TNKL) is an uncommon and heterogeneous group of lymphoid malignancies. We aimed to investigate their subtype distribution, clinicopathologic characteristics, and clinical outcomes. A total of 38 GI-TNKL cases and their clinical and pathological characteristics were analyzed. Read More

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Subacute Enteritis Two Months After COVID-19 Pneumonia With Mucosal Bleeding, Perforation, and Internal Fistulas.

Am Surg 2021 Jun 1:31348211023461. Epub 2021 Jun 1.

Department of Surgery, 12343Texas Tech University Health Sciences Center, Lubbock, TX, USA.

Chronic sequelae of COVID-19 remain undetermined. We report a case of postinfection sequelae in a patient presenting with subacute obstruction 2 months after COVID-19 infection. A 34-year-old man with a prior prolonged hospital stay due to COVID-19 complicated by upper gastrointestinal (GI) bleed presented with subacute obstruction and failure to thrive. Read More

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Appendiceal perforation due to biliary stent migration in a neutropenic patient with lung cancer receiving chemotherapy: A case report.

Mol Clin Oncol 2021 Jul 17;15(1):136. Epub 2021 May 17.

Department of Gastrointestinal Surgery, Kanta-Häme Central Hospital, Hämeenlinna 13530, Finland.

The use of biliary stents has become a common and usually safe procedure. However, the migration of biliary stents is an uncommon but well-recognized event after endoscopic retrograde cholangiopancreatography. The migration of plastic stents usually does not result in complications and are spontaneously eliminated from the gastro-intestinal tract. Read More

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A rare case of idiopathic intrauterine intestinal volvulus complicated with intestinal perforation: a case report from Syria.

J Surg Case Rep 2021 May 27;2021(5):rjab192. Epub 2021 May 27.

Pediatric Department, Tishreen University Hospital, Latakia, Syria.

Fetal intestinal volvulus is rare, but it is a serious condition due to its life-threatening complications. The bowel loop becomes twisted; thus, impaired venous return leads to bowel necrosis. Prenatal volvulus is most secondary to intestinal atresia, arterial supply defect or without any underlying cause, with consideration that cystic fibrosis is the cause of the intestinal obstruction, because of meconium ileus. Read More

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Abdominal wall reconstruction after emergent surgery for fistulizing incarcerated ventral wall hernia in morbidly obese patient.

Pol Przegl Chir 2020 Oct;93(2):1-5

Department of Surgery, University Hospital Centre Zagreb, Croatia.

Background: Incarcerated abdominal wall hernias may have a variety of manifestations and the most dreaded consequence is strangulation leading to obstruction and perforation of hollow viscus. Very rarely, such a perforation presents with fistulization into the abdominal wall and skin, which is often not considered but may complicate the management approach. <br/>Case presentation: We reported on presentation and management of a 56-year-old morbidly obese male with a fistulizing incarcerated ventral wall hernia and postoperative abdominal wall necrosis. Read More

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October 2020

Blinatumomab-related pneumatosis intestinalis in a pediatric patient with relapsed acute lymphoblastic leukemia: A case report.

J Oncol Pharm Pract 2021 May 30:10781552211015776. Epub 2021 May 30.

Department of Pediatrics, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu, South Korea.

Introduction: Pneumatosis intestinalis is characterized by air in the subserosal or submucosal layer of the intestine, with the severity ranging from mild and asymptomatic to symptomatic with serious conditions such as intestinal ischemia and perforation requiring surgery. Although several etiologies, including those from conventional chemotherapy agents and molecular target agents, have been suggested, blinatumomab-related pneumatosis intestinalis is quite rare.

Case Report: An 11-year-old girl with history of B-cell ALL presented with bone marrow relapse 3 years after completion of initial chemotherapy. Read More

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Intestinal Obstruction Secondary to Multiple Gastrointestinal phytobezoars, A Rare presentation.

Int J Surg Case Rep 2021 May 21;83:106004. Epub 2021 May 21.

Department of General Surgery, Qatif Central Hospital, Qatif, Saudi Arabia.

Introduction: Intestinal obstruction considered to be one of the most common surgical presentation. Adhesions secondary to previous operations, hernias, neoplasms, inflammatory bowel disease, intussusception, or volvulus are the usual causes of intestinal obstruction but bezoar can presents in 0.4-4%. Read More

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Adult-onset autoinflammation caused by somatic mutations in UBA1: A Dutch case series of VEXAS patients.

J Allergy Clin Immunol 2021 May 25. Epub 2021 May 25.

Department of Rheumatology and Clinical Immunology, University Medical Center Groningen, University of Groningen, The Netherlands. Electronic address:

Background: A novel autoinflammatory syndrome was described recently in male patients who harboured somatic mutations in the X-chromosomal UBA1 gene. These patients were characterized by adult-onset, treatment-refractory inflammation with fever, cytopenias, dysplastic bone marrow, vacuoles in myeloid and erythroid progenitor cells, cutaneous and pulmonary inflammation, chondritis and vasculitis, abbreviated as VEXAS.

Objective: This study aimed to (retrospectively) diagnose VEXAS in patients that had been previously registered with unclassified autoinflammation. Read More

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Fulminant amebic colitis in a patient with concomitant cytomegalovirus infection after systemic steroid therapy: A case report.

World J Clin Cases 2021 May;9(15):3726-3732

Department of Respiratory Medicine and Allergology, Sapporo Medical University School of Medicine, Sapporo 060-8556, Japan.

Background: Amebic colitis is an infection caused by and most commonly observed in regions with poor sanitation. It is also seen as a sexually transmitted disease in developed countries. While amebic colitis usually has a chronic course with repeated exacerbations and remissions, it may also manifest as a fulminant form that rapidly progresses and leads to severe, life-threatening complications, such as intestinal perforation, peritonitis, and sepsis, that have a high mortality rate. Read More

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Primary duodenal tuberculosis complicated with perforation: A review of literature and case report.

Ann Med Surg (Lond) 2021 Jun 12;66:102392. Epub 2021 May 12.

Department of Digestive Surgery 'A', La Rabta Hospital University, Faculty of Medicine of Tunis, Tunisia.

Tuberculous (TB) disease remains an endemic pathology in Tunisia. the ileocecal region is the predominant site of involvement while gastroduodenal tuberculosis is very rare, this form is often presenting as one of the complications, mainly upper gastrointestinal stenosis or exceptionally as a perforation. We describe a case of female patient aged 33 years-old presented with a 2-day history of acute abdominal pain, with a tenderness of the right hypochondrium and the epigastrium, ultrasound of the abdomen revealed gallbladder distension with a wall thickening. Read More

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Gastric perforation by fish bone with hepatic abscess formation presenting as prolonged fever.

IDCases 2021 12;24:e01159. Epub 2021 May 12.

Centro Hospitalar Universitário do Porto EPE, Internal Medicine Department, Alameda Prof. Hernâni Monteiro, Porto, PT 4200-319, Portugal.

A 70-year-old woman presented to the emergency department with a 3-week history of prolonged fever, asthenia and anorexia, denying other symptoms. Physical examination was unremarkable and the patient admitted for further investigation. Initial laboratory testing showed leucocytosis, elevated C-reactive protein and cholestasis, without hyperbilirubinemia or cytolysis. Read More

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Gastrointestinal perforation following dabrafenib and trametinib administration in non-small cell lung carcinoma with BRAF V600E mutation: a case report and literature review.

Invest New Drugs 2021 May 23. Epub 2021 May 23.

Department of Respiratory Medicine, Kobe City Medical Center General Hospital, 2-1-1 Minatojima-Minamimachi, Chuo-Ku, Kobe, 650-0047, Japan.

Gastrointestinal perforation related to mitogen-activated protein kinase kinase (MEK) inhibitors has been reported previously; however, there has been no case report of such a condition in patients with non-small cell lung cancer (NSCLC). Herein, we report a case of small intestinal perforation secondary to dabrafenib and trametinib administration, but not related to tumor regression. A 62-year-old man with non-small cell lung cancer harboring BRAF V600E mutation was treated with dabrafenib and trametinib. Read More

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A critical evaluation of current definitions of necrotizing enterocolitis.

Pediatr Res 2021 May 21. Epub 2021 May 21.

Department of Microbiology & Immunology, University of Iowa, Iowa City, IA, USA.

Background: Necrotizing enterocolitis (NEC) is a devastating intestinal disease of premature infants, with significant mortality and long-term morbidity among survivors. Multiple NEC definitions exist, but no formal head-to-head evaluation has been performed. We hypothesized that contemporary definitions would perform better in evaluation metrics than Bell's and range features would be more frequently identified as important than yes/no features. Read More

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Delta neutrophil index and symptomatic time are effective factors for predicting perforated appendicitis.

Medicine (Baltimore) 2021 May;100(20):e25935

Department of Surgery, Kangdong Sacred Heart Hospital.

Abstract: Appendicitis is a common intra-abdominal inflammatory disease, and morbidity increases with age when perforation occurs. Because, not all patients require emergency surgery, there have been numerous studies on factors for predicting perforated appendicitis. In this study, we aimed to confirm whether the delta neutrophil index (DNI) and the time from symptom onset to surgery are effective predictors for perforated appendicitis in different age groups. Read More

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Medico-legal implications for the colon perforation during colonoscopy.

J Forensic Leg Med 2021 May 12;80:102185. Epub 2021 May 12.

Department of Nursing, Gwangju University, Gwangju, Republic of Korea. Electronic address:

Colon perforation is the most serious complication of colonoscopy, and tends to be considered as malpractice. The aim of this study was to identify the characteristics and causes of medical accidents by analyzing lawsuit cases on colon perforation during colonoscopy. We collected judgment results that were ruled from 2005 to 2015 using the keyword 'colonoscopy' in the 'Korea's Written Judgment Public Reading System' of the Supreme Court, and extracted the cases of colon perforation. Read More

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A Case of Self-Induced Hydrostatic Colonic Perforation.

Qatar Med J 2021 29;2021(1):14. Epub 2021 Apr 29.

Department of Surgery, Faculty of Medicine, King Khalid University, P.O. Box 641, Abha 61421, Saudi Arabia E-mail:

Introduction: Constipation is a common complaint. The elderly are five times more prone to constipation than young people because of the effects of medication, immobility, and a blunted urge to defecate. Many of these patients are demented, have cognitive deficits, or suffer from a psychiatric disorder. Read More

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