584,626 results match your criteria Intestinal Perforation


The burden and epidemiology of polyparasitism among rural communities in Kano State, Nigeria.

Trans R Soc Trop Med Hyg 2018 Dec 14. Epub 2018 Dec 14.

Department of Parasitology, Faculty of Medicine, University of Malaya,Kuala Lumpur, Malaysia.

Background: Parasitic infections constitute a major public health problem worldwide, particularly among underprivileged communities in developing countries including Nigeria. The present study aimed to determine the epidemiology of polyparasitism (multiple parasitic infections) among rural communities in Kano State, North Central Nigeria.

Methods: A total of 551 individuals were screened for the presence of intestinal, urogenital and blood parasites by using different diagnostic techniques. Read More

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December 2018

Effects of early enteral bovine colostrum supplementation on intestinal permeability in critically ill patients: A randomized, double-blind, placebo-controlled study.

Nutrition 2018 Oct 12;60:106-111. Epub 2018 Oct 12.

Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address:

Objectives: In this study we sought to investigate the effect of early enteral bovine colostrum supplementation on intestinal permeability in intensive care unit (ICU)-hospitalized patients.

Methods: A total of 70 ICU-hospitalized adult patients were randomly assigned to receive a bovine colostrum supplement or placebo according to the stratified blocked randomization by age and admission category. Plasma endotoxin and zonulin concentrations were measured on days 5 and 10 of intervention. Read More

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October 2018

Why do current strategies for optimal nutritional therapy neglect the microbiome?

Nutrition 2018 Oct 5;60:100-105. Epub 2018 Oct 5.

Department of Surgery, Oregon Health Sciences University, Portland, Oregon, USA.

Strategies for providing optimal nutritional therapy have evolved over time, with the emphasis on specific directives (such as route, use of immunonutrition, high protein, organ-specific formulas, etc.), achieving variable degrees of success for improving outcomes in the intensive care unit. As the largest immune organ in the body comprising the largest interface between the host and the external environment, the gut can have an amplifying effect on a pattern of dysbiosis, immune dysregulation, and multiple organ failure seen in the critically ill patient. Read More

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October 2018

Comprehensive characterization of in vivo metabolic profile of Polygalae radix based on ultra-high-performance liquid chromatography-tandem mass spectrometry.

J Pharm Biomed Anal 2018 Dec 5;165:173-181. Epub 2018 Dec 5.

National Center of Mass Spectrometry in Changchun and Jilin Province Key Laboratory of Chinese Medicine Chemistry and Mass Spectrometry and Chemical Biology Laboratory, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China; University of Science and Technology of China, Hefei, 230026, China. Electronic address:

In this study, a novel analysis strategy for progressively targeted screening and characterization of drug ingredients from in vitro to in vivo was proposed based on ultra-high performance liquid chromatography-tandem mass spectrometry for comprehensive characterization of in vivo metabolic profile of Polygalae radix (PR). First, an in vitro chemical profile of PR was described with the assistance of UNIFI™ software. The characteristic neutral small molecule losses were summarized to distinguish different chemical structures in the PR extract. Read More

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December 2018

An improved rat model for chronic inflammatory bowel disease.

Pharmacol Rep 2018 Oct 11;71(1):149-155. Epub 2018 Oct 11.

School of Health and Wellbeing, University of Southern Queensland, Toowoomba, QLD, Australia; Functional Foods Research Group, University of Southern Queensland, Toowoomba, QLD, Australia. Electronic address:

Background: Inflammatory bowel disease (IBD) is an important cause of chronic disability in humans.

Methods: We characterized a model of chronic IBD in young male Wistar rats by administering dextran sodium sulfate (DSS: 0%, 0.25%, 0. Read More

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October 2018

Three monophyletic clusters in Retortamonas species isolated from vertebrates.

Parasitol Int 2018 Dec 11. Epub 2018 Dec 11.

Department of Parasitology, Graduate School of Medical Sciences, Kanazawa University, Kanazawa 920-8640, Japan. Electronic address:

Retortamonas spp. has been reported as an intestinal parasite among various host organisms, including humans; however, its intra-genus molecular diversity has not yet been elucidated. Haplotypes of the 18S small subunit ribosomal RNA locus (1836-1899 bp) of Retortamonas spp. Read More

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December 2018

Microcontainers for protection of oral vaccines, in vitro and in vivo evaluation.

J Control Release 2018 Dec 11. Epub 2018 Dec 11.

Department of Micro- and Nanotechnology, Technical University of Denmark, Oersteds Plads 345C, 2800 Kgs., Lyngby, Denmark.

Oral vaccines are highly desirable due to simple logistics, mass vaccination potential and for mucosal immunity. Subunit vaccines are preferred due to high safety, but are inherently difficult to deliver orally, thus providing motivation for the use of advanced oral delivery systems. Polymeric devices in micrometer size (microcontainers) were tested here for this purpose. Read More

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December 2018

Occurrence of virulence factors in Cronobacter sakazakii and Cronobacter malonaticus originated from clinical samples.

Microb Pathog 2018 Dec 11. Epub 2018 Dec 11.

Microbiology Department, Faculty of Biomedical Sciences, Sabha University, Sabha, Libya.

Background: Cronobacter spp. are Gram-negative, facultative-anaerobic, non-spore forming, enteric coliform bacteria, which belongs to the Enterobacteriaceae family. Cronobacter spp. Read More

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December 2018

Plecanatide for Treatment of Chronic Constipation and Irritable Bowel Syndrome.

Authors:
Bryan L Love

Am J Med 2018 Dec 11. Epub 2018 Dec 11.

University of South Carolina College of Pharmacy, Department of Clinical Pharmacy and Outcomes Sciences, Columbia, SC. Electronic address:

Chronic idiopathic constipation and irritable bowel syndrome with constipation are commonly encountered in ambulatory patients, but limited options exist for patients with persistent or severe symptoms following treatment with non-prescription products. Plecanatide (Trulance, Synergy Pharmaceuticals) is a 16-amino acid peptide analogue of uroguanylin that stimulates guanylate cyclase-C receptors to increase chloride and bicarbonate secretion into the intestine and prevents the absorption of sodium ions, thereby increasing the secretion of water into the lumen. The influx of additional fluid accelerates intestinal transit, softens the stool and facilitates easier defecation. Read More

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December 2018

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Klin Lab Diagn 2018 ;63(1):44-50

The Federal state budget educational institution of higher education "The St. Petersburg state pediatric medical university" of Minzdrav of Russia, 194100, St. Petersburg, Russia.

The purpose of study is to establish features of autoimmune reaction of children with Crohn's disease. The sampling included 62 patients aged from 2 to 17 years with diagnosis of Crohn's disease. The evaluation was carried out concerning concentration in blood serum of immunoglobulins IgA, IgM, IgG, IgЕ, antibodies to Saccharomyces cerevisiae (ASCA) classes IgA, IgG и IgЕ, antibodies to Candida albicans classes IgA, IgM, IgG и IgЕ, anti-neutrophilic cytoplasmic antibodies (ANCA) to myeloperoxidase (MPO), to proteinase 3 (PR3), anti-nuclear antibodies (ANA), antibodies to DNAds, DNAss (to double-helical and single-stranded DNA), antibodies to antigens of small and large intestines, pancreas, circulating immune complexes. Read More

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January 2018

Urinary circulating DNA and circulating antigen for diagnosis of schistosomiasis mansoni: a field study.

Trop Med Int Health 2018 Dec 14. Epub 2018 Dec 14.

Medical Biochemistry Department, Faculty of Medicine, University of Alexandria, Egypt.

Objective: To evaluate three non- invasive assays for the diagnosis of schistosomiasis mansoni in an Egyptian village.

Methods: Urine was collected for the detection of circulating cathodic antigen (CCA) and cell free parasite DNA (cfpd) by Point-of-contact (POC)-cassette assay and PCR respectively. These tests were compared to Kato Katz (KK) fecal thick smear for detection of Schistosoma mansoni eggs. Read More

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December 2018

Subtyping of intraductal papillary mucinous neoplasms - pitfalls of MUC1 immunohistochemistry.

APMIS 2019 Jan 22;127(1):27-32. Epub 2018 Nov 22.

Department of Pathology, Copenhagen University Hospital Rigshospitalet, København, Denmark.

Intraductal papillary mucinous neoplasms (IPMNs) are precursor lesions of pancreatic ductal adenocarcinoma (PDAC). Current edition of WHO Classification of Tumors of the Digestive System recognizes four different subtypes (gastric, intestinal, pancreatobiliary, and oncocytic) and recommends analysis of mucin expression (MUC1, MUC2, MUC5AC, MUC6) as well as evaluation of architectural and cell differentiation patterns for correct classification. However, there is no consensus on MUC1 expression of IPMN-lesions in the literature. Read More

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January 2019

Zinc Transport in the Mammalian Intestine.

Compr Physiol 2018 Dec 13;9(1):59-74. Epub 2018 Dec 13.

Military Nutrition Division, U.S. Army Research Institute of Environmental Medicine, Natick, Massachusetts, USA.

Zinc homeostasis is primarily maintained in the proximal small intestine. Sophisticated transport mechanisms maintain zinc homeostasis by controlling the uptake and efflux of zinc in intestinal absorptive epithelial cells. Zrt-irt-like proteins (ZIPs) and zinc transporters (ZnTs) function in a coordinated manner to assimilate zinc from the lumen of the small intestine, subcellular compartments within the absorptive epithelial cell, and circulation. Read More

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December 2018

Amino Acid Transport Across the Mammalian Intestine.

Compr Physiol 2018 Dec 13;9(1):343-373. Epub 2018 Dec 13.

Research School of Biology, The Australian National University, Canberra, ACT 2601, Australia.

The small intestine mediates the absorption of amino acids after ingestion of protein and sustains the supply of amino acids to all tissues. The small intestine is an important contributor to plasma amino acid homeostasis, while amino acid transport in the large intestine is more relevant for bacterial metabolites and fluid secretion. A number of rare inherited disorders have contributed to the identification of amino acid transporters in epithelial cells of the small intestine, in particular cystinuria, lysinuric protein intolerance, Hartnup disorder, iminoglycinuria, and dicarboxylic aminoaciduria. Read More

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December 2018

Identification of ampullary carcinoma mixed subtype using a panel of six antibodies and its clinical significance.

J Surg Oncol 2018 Dec 12. Epub 2018 Dec 12.

Pathology and Laboratory Medicine Department, University of California, Los Angeles, California.

Objectives: To investigate the function of immunomarkers CK7, CK20, CK17, CDX2, MUC1, and MUC2 in the identification of primary ampullary carcinoma mixed subtype.

Methods: Forty-two cases of primary ampullary carcinoma were performed by immunohistochemical studies. The correlation between the mixed subtype and the other two subtypes and patient survival data was analyzed using the SPSS 16. Read More

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December 2018

The inhibitory effects of Qingchang Wenzhong granule on the interactive network of inflammation, oxidative stress, and apoptosis in rats with dextran sulfate sodium-induced colitis.

J Cell Biochem 2018 Dec 11. Epub 2018 Dec 11.

Gastroenterology Department, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, China.

Background: Ulcerative colitis (UC) is a kind of complex immune disease, the pathogenesis of which remains elusive. Destruction of the intestinal barrier, extreme inflammation, oxidative stress, and apoptosis might play key roles in the development of UC. In previous studies, we observed that Qingchang Wenzhong granule (QCWZG) had the exact effect on the remission of UC in the clinic; however, the underlying mechanism has not been identified. Read More

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December 2018
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β-Sitosterol improves experimental colitis in mice with a target against pathogenic bacteria.

J Cell Biochem 2018 Dec 11. Epub 2018 Dec 11.

Department of Colorectal Surgery, The Third Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.

In this article, we aim to examine the novel effects of β-sitosterol on murine experimental colitis. β-Sitosterol significantly reduces the weight loss, colon length, and alleviated microscopic appearances of colitis induced by dextran sulfate sodium. This compound also decreases the levels of TNF-α, IL-6, and IL-1β in intestinal tissue of mice with experimental colitis in a concentration-dependent manner. Read More

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December 2018

Introduction to Themed Series on Intestinal Stem Cells and the NIDDK Intestinal Stem Cell Consortium.

Am J Physiol Gastrointest Liver Physiol 2018 Dec 14. Epub 2018 Dec 14.

University of California at San Francisco, United States.

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December 2018

Prevalence of intestinal parasites and the absence of soil-transmitted helminths in Añatuya, Santiago del Estero, Argentina.

Parasit Vectors 2018 Dec 14;11(1):638. Epub 2018 Dec 14.

Fundación Mundo Sano, Paraguay, 1535, Buenos Aires, Argentina.

Background: Intestinal parasites (IP) have been reported in point studies from different provinces of Argentina. The presence of soil-transmitted helminths (STH) was detected in many of these studies, including varied prevalences of all five species of STH in the north were the climate is more appropriate for transmission. Nonetheless, Argentina lacks a comprehensive prevalence map of STH. Read More

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December 2018

Comparative analysis of Faecalibacterium prausnitzii genomes shows a high level of genome plasticity and warrants separation into new species-level taxa.

BMC Genomics 2018 Dec 14;19(1):931. Epub 2018 Dec 14.

APC Microbiome Ireland, University College Cork, Cork, Ireland.

Background: Faecalibacterium prausnitzii is a ubiquitous member of the human gut microbiome, constituting up to 15% of the total bacteria in the human gut. Substantial evidence connects decreased levels of F. prausnitzii with the onset and progression of certain forms of inflammatory bowel disease, which has been attributed to its anti-inflammatory potential. Read More

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December 2018

Levodopa-carbidopa intestinal gel in a subgroup of patients with dyskinesia at baseline from the GLORIA Registry.

Neurodegener Dis Manag 2018 Dec 14. Epub 2018 Dec 14.

Department of Neuroscience, Padua University, Padua, Italy.

Aim: To evaluate long-term effects of levodopa-carbidopa intestinal gel on dyskinesia burden.

Patients & Methods: Posthoc analysis of the GLORIA registry assessed subgroups of advanced Parkinson's disease patients with <4 and ≥4 h/day of levodopa-induced dyskinesia at baseline.

Results & Conclusions: Mean dyskinesia duration significantly (p < 0. Read More

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December 2018

Intravascular Ultrasound-Assisted Endovascular Treatment of Mesenteric Malperfusion in a Multichannel Aortic Dissection With Full True Lumen Collapse.

J Endovasc Ther 2018 Dec 14:1526602818815821. Epub 2018 Dec 14.

1 Department of Vascular Surgery, Zhongshan Hospital Fudan University, Shanghai, China.

Purpose: To describe endovascular treatment of mesenteric malperfusion in a multichannel aortic dissection (MCAD) with full true lumen (TL) collapse following thoracic endovascular aortic repair (TEVAR).

Case Report: A 54-year-old man presented with chronic mesenteric ischemia and a previous TEVAR for MCAD complicated by superior mesenteric artery (SMA) malperfusion. Computed tomography angiography (CTA) demonstrated a 3-channel aortic dissection with a "false-true-false" configuration. Read More

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December 2018

[Role of prebiotics and probiotics in the functionality of the microbiota in the patients receiving enteral nutrition].

Nutr Hosp 2018 Apr 3;35(Spec no2):18-26. Epub 2018 Apr 3.

.

Set of resident microorganisms in our body that are responsible for the absorption of nutrients and the maintenance of health is named microbiota. The microbiota´s role is protective, trophic and metabolic. Different groups of microbiota intestinal name enterotypes, each one of them are in relation to specific dietary habits. Read More

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[Innovation in the incorporation of macronutrients to enteral nutrition formulas].

Nutr Hosp 2018 Apr 3;35(Spec no2):4-12. Epub 2018 Apr 3.

.

Enteral nutrition consists of the administration of chemically defined nutrients which are partially or fully metabolised in the intestinal tract, by the oral route or through a tube, to get an adequate and efficient nutritional supply. Enteral nutrition is the first option when one needs artificial nutrition, keeping parenteral nutrition only for those cases for which enteral nutrition would be insufficient or impossible. Enteral nutrition formulas are classified according to their composition with complete or uncompleted supply of nutrients, administration route, and protein content, energy density and type and content of fibre, and in second term according to general or special purposes utilization. Read More

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Crohn's colitis-induced myocarditis.

J Cardiol Cases 2016 Jul 7;14(1):4-7. Epub 2016 Apr 7.

Division of Cardiology, Northwestern Memorial Hospital, Chicago, IL, USA.

Myocarditis can be idiopathic or arise in response to numerous systemic insults. Myocarditis occurring in the setting of an exacerbation of inflammatory bowel disease is a rare extra-intestinal manifestation of both ulcerative and Crohn's-related colitis. Here, we present a unique case of a 56-year-old female patient presenting with an acute Crohn's colitis flare that was eventually complicated by myocarditis. Read More

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Corticosteroid prophylaxis for fetal immaturity in a pregnant patient with atrial myxoma.

J Cardiol Cases 2016 Mar 19;13(3):67-69. Epub 2015 Sep 19.

Department of Cardiac Surgery, "G. D'Annunzio" University, Chieti, Pescara, Italy.

We report a case of a woman at 32nd gestational week, admitted for resting dyspnea, showing left atrial (LA) myxoma. Cardiac myxomas are the most common primary benign tumors of the heart. The incidence of cardiac myxomas diagnosed in pregnancy is extremely low. Read More

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Control of acute phase intestinal bleeding after percutaneous coronary intervention by discontinuing dual antiplatelet therapy and implementing intra-aortic balloon pumping.

J Cardiol Cases 2015 Apr 22;11(4):113-116. Epub 2015 Jan 22.

Department of Cardiology, Sakakibara Heart Institute, Tokyo, Japan.

Aspirin's efficacy for the prevention of secondary vascular disease is well supported. However, more attention should be given to its side effects, especially gastrointestinal injury. A 62-year-old man suffered acute myocardial infarction of the left main trunk. Read More

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INTESTINAL OBSTRUCTION CAUSED BY APPENDICITIS: A SYSTEMATIC REVIEW.

J West Afr Coll Surg 2017 Jul-Sep;7(3):94-115

Department of Surgery, National Hospital, Garki, Abuja, Nigeria.

Background: The known complications of appendicitis include perforated appendicitis with generalised peritonitis, appendiceal mass, appendiceal abscess, sepsis, adhesion formation and in a few occasions, small bowel intestinal obstruction.

Aim: To review published cases of intestinal obstruction due to appendicitis with a view to better understand the pathophysiology of this complication.

Methodology: A search of the literature in the MEDLINE database, using PubMed and OvidSP, Scopus, Google Scholar and Cochrane Databases with the following MeSH terms: was done. Read More

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December 2018

Use of the Physiologically Based Extraction Test for the Assessment of Bioaccessibility of Toxic Metals in Vegetables Grown on Contaminated Soils.

J Health Pollut 2016 Jun 30;6(10):74-83. Epub 2016 Jun 30.

Background: An important concern for human health is the uptake of toxic metals by vegetables from soils and their consumption by humans.

Objectives: To assess the oral bioaccessibility of metals in vegetables (spinach, pumpkin, celosia, okro leaves and waterleaf) grown on contaminated soils collected from five different sites in Lagos, Nigeria.

Methods: The soil and vegetables were acid digested and the total metal concentrations (copper (Cu), cadmium (Cd), chromium (Cr), lead (Pb) and zinc (Zn)) were determined using a flame atomic absorption spectrophotometer. Read More

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A review of filamin A mutations and associated interstitial lung disease.

Eur J Pediatr 2018 Dec 13. Epub 2018 Dec 13.

Clinical Genetics Department, Our Lady's Children's Hospital, Dublin, Ireland.

The filamin A gene (FLNA) on Xq28 encodes the filamin A protein. Mutation in FLNA causes a wide spectrum of disease including skeletal dysplasia, neuronal migration abnormality, cardiovascular malformation, intellectual disability and intestinal obstruction. Recently, childhood-onset interstitial lung disease associated with a range of FLNA mutations has been recognised and reported. Read More

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December 2018
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Prevalence of geophagy and knowledge about its health effects among native Sub-Saharan Africa, Caribbean and South America healthy adults living in France.

Eat Weight Disord 2018 Dec 13. Epub 2018 Dec 13.

Service de Médecine Interne et des Maladies Infectieuses et Tropicales, Centre Hospitalier Universitaire Reims, 51092, Reims, France.

Geophagy is widespread among women from Sub-Saharan Africa, South America and the Caribbean and may persist in western countries. This practice may be associated with adverse effects such as anaemia, constipation or intestinal occlusion. We aimed to determine the prevalence of geophagy and the level of knowledge about its health effects among healthy adults originating from these countries and attending a travel medicine and international vaccination consultation in France. Read More

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December 2018
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Cecal coccidiosis in turkeys: Comparative biology of Eimeria species in the lower intestinal tract of turkeys using genetically typed, single oocyst-derived lines.

Parasitol Res 2018 Dec 13. Epub 2018 Dec 13.

Department of Pathobiology, University of Guelph, Guelph, Ontario, N1G2W1, Canada.

Differentiating the Eimeria species causing cecal coccidiosis in turkeys is challenging. To obtain benchmark biological data for Eimeria gallopavonis Hawkins 1952 and Eimeria meleagridis Tyzzer 1929 and to support the stability of the species concept for each, genetically typed, single oocyst-derived lines of E. gallopavonis Weybridge strain and E. Read More

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December 2018

Comparative analysis of the intestinal bacterial community and expression of gut immunity genes in the Chinese Mitten Crab (Eriocheir sinensis).

AMB Express 2018 Dec 13;8(1):192. Epub 2018 Dec 13.

Liaoning Provincial Key Laboratory of Zoonosis, College of Animal Science & Veterinary Medicine, Shenyang Agricultural University, Shenyang, Liaoning, 110866, People's Republic of China.

Remarkably little information is available about the interaction between the gut microbiota and intestinal immunity in fish and crustaceans. In our study, we used Illumina MiSeq sequencing and real-time quantitative PCR to compare the microbial community and immunity genes expression in the foregut, midgut and hindgut of Chinese mitten crab (Eriocheir sinensis). Our results indicated that the community richness of the midgut is higher than in the foregut or the hindgut, although the bacterial diversity in the hindgut is higher. Read More

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December 2018

The spectrum of cloacal malformations: how to differentiate each entity prenatally with fetal MRI.

Pediatr Radiol 2018 Dec 13. Epub 2018 Dec 13.

Department of Diagnostic Radiology, Division of Pediatric Radiology,, Children's Hospital Colorado,, 13123 East 16th Ave., Mailbox B-463,, Aurora, CO, 80045, USA.

The term cloacal malformation is commonly used to describe the classic cloacal malformation where there is a single common urogenital and intestinal channel located at the expected site of the urethra. There is, however, a spectrum of cloacal abnormalities that differ from this classic type and are less well discussed in the radiologic and surgical literature. The aim of this pictorial essay is to familiarize radiologists with the anatomy, appropriate terminology and key prenatal imaging findings that differentiate the six entities that constitute the spectrum of cloacal abnormalities. Read More

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December 2018
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IVIM with fractional perfusion as a novel biomarker for detecting and grading intestinal fibrosis in Crohn's disease.

Eur Radiol 2018 Dec 13. Epub 2018 Dec 13.

Department of Radiology, The First Affiliated Hospital, Sun Yat-Sen University, 58 Zhongshan II Road, Guangzhou, 510080, People's Republic of China.

Objectives: Intravoxel incoherent motion (IVIM) diffusion-weighted magnetic resonance imaging (MRI) provides information on both perfusion and diffusion and has been used to evaluate Crohn's disease (CD) activity and fibrosis in children; however, there are no reports on its use in adults. We aimed to determine its value for detecting and grading intestinal fibrosis in adults with CD compared with contrast-enhanced imaging and traditional diffusion-weighted imaging using surgical histopathology as a reference standard.

Methods: Twenty-four adults with CD underwent preoperative IVIM, traditional diffusion-weighted, and contrast-enhanced imaging. Read More

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December 2018

An Uncommon Presentation of Leiomyoma Cecum as a Subcutaneous Abscess of the Right Flank.

Cureus 2018 Oct 9;10(10):e3432. Epub 2018 Oct 9.

Otolaryngology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, IND.

Cecal leiomyomas are rare benign tumors of smooth muscle arising from the colonic muscularis mucosa or muscularis propria. They are usually asymptomatic in nature and, if symptomatic, may present as pain in the abdomen, intestinal obstruction, or bleeding. In some cases, leiomyoma can cause free perforation leading to peritonitis. Read More

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October 2018
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Aggressive undifferentiated pleomorphic sarcoma of the stomach involving long-term survival: A case report and literature review.

Mol Clin Oncol 2018 Dec 5;9(6):661-665. Epub 2018 Oct 5.

Department of Pathology, Tokyo Metropolitan Cancer and Infectious Disease Center Komagome Hospital, Tokyo 113-0021, Japan.

Primary gastric undifferentiated pleomorphic sarcoma (UPS) is a rare disease with insufficient long-term follow-up data. In the present study, a 70-year-old male complained of abdominal fullness and visited our hospital. Abdominal computed tomography revealed a large tumor in the upper part of the stomach, which was accompanied by smaller tumors in the small intestinal mesentery. Read More

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December 2018

Traumatic Brain Injury in Mice Induces Acute Bacterial Dysbiosis Within the Fecal Microbiome.

Front Immunol 2018 27;9:2757. Epub 2018 Nov 27.

Center for Neuroregeneration, Houston Methodist Research Institute, Houston, TX, United States.

The secondary injury cascade that is activated following traumatic brain injury (TBI) induces responses from multiple physiological systems, including the immune system. These responses are not limited to the area of brain injury; they can also alter peripheral organs such as the intestinal tract. Gut microbiota play a role in the regulation of immune cell populations and microglia activation, and microbiome dysbiosis is implicated in immune dysregulation and behavioral abnormalities. Read More

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November 2018
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Corrigendum: A Review: The Fate of Bacteriocins in the Human Gastro-Intestinal Tract: Do They Cross the Gut-Blood Barrier?

Front Microbiol 2018 30;9:2938. Epub 2018 Nov 30.

Department of Microbiology, Stellenbosch University, Stellenbosch, South Africa.

[This corrects the article DOI: 10.3389/fmicb.2018. Read More

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November 2018

Anaerobic Degradation of the Plant Sugar Sulfoquinovose Concomitant With HS Production: K-12 and sp. Strain DF1 as Co-culture Model.

Front Microbiol 2018 27;9:2792. Epub 2018 Nov 27.

Department of Biology, University of Konstanz, Konstanz, Germany.

Sulfoquinovose (SQ, 6-deoxy-6-sulfoglucose) is produced by plants and other phototrophs and its biodegradation is a relevant component of the biogeochemical carbon and sulfur cycles. SQ is known to be degraded by aerobic bacterial consortia in two tiers via C-organosulfonates as transient intermediates to CO, water and sulfate. In this study, we present a first laboratory model for anaerobic degradation of SQ by bacterial consortia in two tiers to acetate and hydrogen sulfide (HS). Read More

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November 2018

Intestinal-type adenocarcinoma of the vagina: clinico-pathologic features of a common tumor with a rare localization.

Pathologica 2018 Sep;110(2):92-95

Department of Medical and Surgical Sciences and Advanced Technologies, G.F. Ingrassia, Azienda Ospedaliero-Universitaria "Policlinico-Vittorio Emanuele", Anatomic Pathology Section, School of Medicine, University of Catania, Italy.

Intestinal-type adenocarcinoma is a rare primary vaginal carcinoma and considerably more uncommon than metastatic lesions which represent the most frequent malignancy at this anatomic site. Among all malignant tumors, colorectal, breast and female genital tract carcinomas have the tendency to metastasize to the vagina.

As morphologic and immunohistochemical features of intestinal-type adenocarcinoma occurring primarily in the vagina are not specific, clinical and radiologic information is crucial to exclude a metastatic lesion. Read More

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September 2018

Impact of CFTR modulation with Ivacaftor on Gut Microbiota and Intestinal Inflammation.

Sci Rep 2018 Dec 13;8(1):17834. Epub 2018 Dec 13.

Department of Paediatrics, Division of Gastroenterology, Hepatology and Nutrition, The Hospital for Sick Children, Toronto, Ontario, Canada.

Cystic fibrosis (CF) is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. Next to progressive airway disease, CF is also associated with intestinal inflammation and dysbiosis. Ivacaftor, a CFTR potentiator, has improved pulmonary and nutritional status but its effects on the intestinal microbiota and inflammation are unclear. Read More

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December 2018
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Characterisation of small molecule ligands 4CMTB and 2CTAP as modulators of human FFA2 receptor signalling.

Sci Rep 2018 Dec 13;8(1):17819. Epub 2018 Dec 13.

Institute for Molecular Bioscience, The University of Queensland, Brisbane, Australia.

Short chain fatty acids (SCFAs) are protective against inflammatory diseases. Free fatty acid receptor 2 (FFA2), is a target of SCFAs however, their selectivity for FFA2 over other FFA receptors is limited. This study aimed to functionally characterise 2-(4-chlorophenyl)-3-methyl-N-(thiazole-2-yl)butanamide (4CMTB) and 4-((4-(2-chlorophenyl)thiazole-2-yl)amino)-4oxo-3-phenylbutanoic acid (2CTAP), and their enantiomers, in modulating FFA2 activity. Read More

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December 2018

Antibiotics may increase triazine herbicide exposure risk via disturbing gut microbiota.

Microbiome 2018 Dec 13;6(1):224. Epub 2018 Dec 13.

Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Science, China Agricultural University, No. 2, West Yuanmingyuan Road, Beijing, 100193, People's Republic of China.

Background: Antibiotics are commonly used worldwide, and pesticide is a kind of xenobiotic to which humans are frequently exposed. The interactive impact of antibiotics on pesticides has rarely been studied. We aim to investigate the effects of antibiotics on the pesticide exposure risk and whether gut microbiota altered by antibiotics has an influence on pesticide bioavailability. Read More

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December 2018
1 Read

[Role of prebiotics and probiotics in the functionality of the microbiota in the patients receiving enteral nutrition].

Nutr Hosp 2018 Apr 3;0(0):18-26. Epub 2018 Apr 3.

.

Set of resident microorganisms in our body that are responsible for the absorption of nutrients and the maintenance of health is named microbiota. The microbiota´s role is protective, trophic and metabolic. Different groups of microbiota intestinal name enterotypes, each one of them are in relation to specific dietary habits. Read More

View Article
April 2018
1 Read

[Innovation in the incorporation of macronutrients to enteral nutrition formulas].

Nutr Hosp 2018 Apr 3;0(0):4-12. Epub 2018 Apr 3.

.

Enteral nutrition consists of the administration of chemically defined nutrients which are partially or fully metabolised in the intestinal tract, by the oral route or through a tube, to get an adequate and efficient nutritional supply. Enteral nutrition is the first option when one needs artificial nutrition, keeping parenteral nutrition only for those cases for which enteral nutrition would be insufficient or impossible. Enteral nutrition formulas are classified according to their composition with complete or uncompleted supply of nutrients, administration route, and protein content, energy density and type and content of fibre, and in second term according to general or special purposes utilization. Read More

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Intestinal Anti-Inflammatory Activity of the Aqueous Extract from Ipomoea asarifolia in DNBS-Induced Colitis in Rats.

Int J Mol Sci 2018 Dec 12;19(12). Epub 2018 Dec 12.

Department of Biophysics and Pharmacology, Biosciences Center, Federal University of Rio Grande do Norte, Natal 59072-970, Brazil.

Inflammatory bowel disease is triggered by an uncontrolled immune response associated with genetic, environmental, and intestinal microbiota imbalance. Ipomoea asarifolia (IA), popularly known as "salsa" or "brave salsa", belongs to the Convolvulaceae family. The aim of this approach was to study the preventive effect of IA aqueous extract in 2,4-dinitrobenzene sulfonic acid (DNBS)-induced colitis in rats. Read More

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December 2018

Correction: Schreck, K. and Melzig, M.F. Intestinal Saturated Long-Chain Fatty Acid, Glucose and Fructose Transporters and their Inhibition by Natural Plant Extracts in Caco-2 Cells. Molecules, 2018, 23, 2544.

Molecules 2018 Dec 11;23(12). Epub 2018 Dec 11.

Institute of Pharmacy-Pharmaceutical Biology, Freie Universitaet Berlin, Koenigin-Luise-Str. 2+4, D-14195 Berlin, Germany.

The authors wish to make the following correction to their paper [... Read More

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December 2018

Membrane and Cytoplasmic Proteins of subspecies that Bind to Novel Monoclonal Antibodies.

Microorganisms 2018 Dec 11;6(4). Epub 2018 Dec 11.

Ruminant Diseases Immunology Research Unit, National Animal Disease Center, USDA-Agricultural Research Service, Ames, IA 50010, USA.

Monoclonal antibodies against subspecies proteins are important tools in Johne's disease research and diagnostics. Johne's disease is a chronic inflammatory intestinal disease of cattle, sheep, and other ruminant animals. We have previously generated multiple sets of monoclonal antibodies (mAbs) in different studies; however, because many were generated and screened against a whole-cell extract of , the antigens that bind to these antibodies remained unknown. Read More

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December 2018
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Iron Supplements Containing 299v Increase Ferric Iron and Up-regulate the Ferric Reductase DCYTB in Human Caco-2/HT29 MTX Co-Cultures.

Nutrients 2018 Dec 8;10(12). Epub 2018 Dec 8.

Department of Biology and Biological Engineering, Chalmers University of Technology, SE-41296 Gothenburg, Sweden.

Several human interventions have indicated that 299v ( 299v) increases intestinal iron absorption. The aim of the present study was to investigate possible effects of 299v on the mechanisms of iron absorption on the cellular level. We have previously shown that lactic fermentation of vegetables increased iron absorption in humans. Read More

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December 2018
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