11,929 results match your criteria Intestinal Motility Disorders


Inhibition of APE1/Ref-1 Redox Signaling Alleviates Intestinal Dysfunction and Damage to Myenteric Neurons in a Mouse Model of Spontaneous Chronic Colitis.

Inflamm Bowel Dis 2020 Jul 3. Epub 2020 Jul 3.

Institute for Health and Sport, Victoria University; Western Centre for Health, Research and Education, Sunshine Hospital, Melbourne, Victoria, Australia.

Background: Inflammatory bowel disease (IBD) associates with damage to the enteric nervous system (ENS), leading to gastrointestinal (GI) dysfunction. Oxidative stress is important for the pathophysiology of inflammation-induced enteric neuropathy and GI dysfunction. Apurinic/apyrimidinic endonuclease 1/redox factor-1 (APE1/Ref-1) is a dual functioning protein that is an essential regulator of the cellular response to oxidative stress. Read More

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http://dx.doi.org/10.1093/ibd/izaa161DOI Listing

Intestinal goblet cells protect against GVHD after allogeneic stem cell transplantation via Lypd8.

Sci Transl Med 2020 Jul;12(550)

Department of Hematology, Hokkaido University Faculty of Medicine and Graduate School of Medicine, Sapporo 060-8638, Japan.

Graft-versus-host disease (GVHD) and infection are major obstacles to successful allogeneic hematopoietic stem cell transplantation (HSCT). Intestinal goblet cells form the mucus layers, which spatially segregate gut microbiota from host tissues. Although it is well known that goblet cell loss is one of the histologic features of GVHD, effects of their loss in pathophysiology of GVHD remain to be elucidated. Read More

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http://dx.doi.org/10.1126/scitranslmed.aaw0720DOI Listing

BOWEL FREQUENCY AND SYMPTOMS OF CONSTIPATION AND ITS RELATION WITH THE LEVEL OF PHYSICAL ACTIVITY IN PATIENTS WITH CHAGAS DISEASE.

Arq Gastroenterol 2020 Apr-Jun;57(2):161-166

Universidade Estadual de Maringá, Departamento de Ciências Básicas da Saúde, Parasitologia, Maringá, PR, Brasil.

Background: Intestinal constipation (IC) in patients with the digestive form of Chagas disease is one of the main reasons for seeking medical care. Population data indicate that the practice of physical activity improves gastrointestinal motility.

Objective: This study evaluated the bowel frequency and symptoms of constipation and their relationship with the level of physical activity in patients with and without Chagas disease. Read More

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http://dx.doi.org/10.1590/S0004-2803.202000000-30DOI Listing
December 2019

The Practice of Gastrointestinal Motility Laboratory During COVID-19 Pandemic: Position Statements of the Asian Neurogastroenterology and Motility Association (ANMA-GML-COVID-19 Position Statements).

J Neurogastroenterol Motil 2020 Jun;26(3):299-310

Division of Gastroenterology and Hepatology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan.

During the Coronavirus Disease 2019 (COVID-19) pandemic, practices of gastrointestinal procedures within the digestive tract require special precautions due to the risk of contraction of severe acute respiratoy syndrome coronavirus-2 (SARS-CoV-2) infection. Many procedures in the gastrointestinal motility laboratory may be considered moderate to high-risk for viral transmission. Healthcare staff working in gastrointestinal motility laboratories are frequently exposed to splashes, air droplets, mucus, or saliva during the procedures. Read More

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http://dx.doi.org/10.5056/jnm20107DOI Listing

PchE Regulation of O157:H7 Flagella, Controlling the Transition to Host Cell Attachment.

Int J Mol Sci 2020 Jun 28;21(13). Epub 2020 Jun 28.

Molecular Characterization of Foodborne Pathogens Research Unit, Eastern Regional Research Center, Agricultural Research Service, United States Department of Agriculture, Wyndmoor, PA 19038, USA.

Shiga toxins and intimate adhesion controlled by the locus of enterocyte effacement are major enterohemorrhagic (EHEC) virulence factors. Curli fimbriae also contribute to cell adhesion and are essential biofilm components. The transcriptional regulator PchE represses the expression of curli and their adhesion to HEp-2 cells. Read More

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http://dx.doi.org/10.3390/ijms21134592DOI Listing

Laparoscopic transhiatal surgery for an epiphrenic esophageal diverticulum derived from a jackhammer esophagus: a case report.

Surg Case Rep 2020 Jun 29;6(1):151. Epub 2020 Jun 29.

Department of Gastroenterological and Pediatric Surgery, Oita University Faculty of Medicine, Idaigaoka 1-1, Hasama-machi, Oita, 879-5593, Japan.

Background: An esophageal diverticulum is rare and is frequently associated with esophageal motility disorders. Jackhammer esophagus is also rare, is characterized by esophageal hypercontraction, and comprises 4.1% of esophageal motility disorders. Read More

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http://dx.doi.org/10.1186/s40792-020-00900-2DOI Listing

Outcomes after enterostomies in children with and without motility disorders: A description and comparison of postoperative complications.

J Pediatr Surg 2020 May 28. Epub 2020 May 28.

Department of Pediatric Gastroenterology and Nutrition, Emma Children's Hospital, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.

Purpose: To provide an overview of complications after ileostomy or colostomy procedures in children, and to compare outcomes between patients with gastrointestinal motility disorders (i.e. functional constipation, Hirschsprung's disease, pediatric intestinal pseudo-obstruction (PIPO)) and children without motility disorders (including necrotizing enterocolitis, anorectal malformation and inflammatory bowel disease). Read More

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http://dx.doi.org/10.1016/j.jpedsurg.2020.05.027DOI Listing

Botulinum Toxin as a Treatment for Feeding Difficulties in Young Children.

J Pediatr 2020 Jun 26. Epub 2020 Jun 26.

Aerodigestive Center, Center for Motility and Functional Gastrointestinal Disorders, Division of Gastroenterology, Hepatology & Nutrition, Boston Children's Hospital, Boston, MA. Electronic address:

Objective: To determine the effectiveness of intrapyloric botulinum toxin injection (IPBI) for treatment of feeding disorders and associated gastrointestinal symptoms in very young children.

Study Design: A single-center retrospective study of patients 2 months to 5 years old who received IPBI at Boston Children's Hospital from May 2007 to June 2019 was performed. Charts were reviewed for demographic data, comorbidities, symptoms leading to IPBI, oral and tube feeding data, symptom improvement after IPBI, and need for repeat injections. Read More

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http://dx.doi.org/10.1016/j.jpeds.2020.06.063DOI Listing

[Pay attention to the diagnosis and treatment of intestinal infectious diarrhea after colorectal surgery].

Authors:
C Ye Q Y Chen J Jiang

Zhonghua Wei Chang Wai Ke Za Zhi 2020 Jul;23(Z1):32-37

Research Institute of General Surgery, Jinling Hospital, Nanjing, Jiangsu 210002, China.

Colorectal surgery patients have severe intestinal flora disorders and antibiotic resistant bacteria due to the disease itself and preoperative treatment, as well as the influence of dietary structure and environmental factors. Perioperative anesthesia and operative stress can cause gastrointestinal motility disorders. In addition, the widespread use of prophylactic broad-spectrum antibiotics and antiacids aggravate intestinal flora disorders and induces severe postoperative infectious diarrhea, such as pseudomembranous enteritis and fatal enteritis. Read More

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http://dx.doi.org/10.3760/cma.j.cn.441530-20200414-00208DOI Listing

Involvement of proBDNF in Monocytes/Macrophages with Gastrointestinal Disorders in Depressive Mice.

Neurotox Res 2020 Jun 25. Epub 2020 Jun 25.

Department of Anesthesiology, The Second Xiangya Hospital, Central South University, Changsha, China.

Major depressive disorders (MDD) are often comorbid with the gastrointestinal (GI) disorders. Brain-derived neurotrophic factor precursor (proBDNF) has been reported to contribute to the development of depression in mouse models. However, the role of proBDNF in depression-associated GI disorders is still unrevealed. Read More

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http://dx.doi.org/10.1007/s12640-020-00235-8DOI Listing

Comparison of Meconium Microbiome in Dizygotic and Monozygotic Twins Born by Caesarean Section (CS).

Front Microbiol 2020 3;11:1139. Epub 2020 Jun 3.

Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.

The early-life microbiota triggers life-long effects on physiological functions and health disorders. Previous studies in adult twins or animal models have revealed associations between host genetics and the harmonious microbiota. However, such associations may be obscured by the fact that each intra-pair of twins will continually encounter various environmental factors as they grow up. Read More

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http://dx.doi.org/10.3389/fmicb.2020.01139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7283445PMC

Envelope Stress and Regulation of the Pathogenicity Island I Type III Secretion System.

J Bacteriol 2020 Jun 22. Epub 2020 Jun 22.

Department of Microbiology, University of Illinois at Urbana-Champaign

Typhimurium uses a type three secretion system (T3SS) encoded on the pathogenicity island 1 (SPI1) to invade intestinal epithelial cells and induce inflammatory diarrhea. The SPI1 T3SS is regulated by numerous environmental and physiological signals, integrated to either activate or repress invasion. Transcription of , encoding the transcriptional activator of the SPI1 structural genes, is activated by three AraC-like regulators, HilD, HilC, and RtsA, that act in a complex feed forward loop. Read More

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http://dx.doi.org/10.1128/JB.00272-20DOI Listing

Ghrelin inhibits autonomic response to gastric distension in rats by acting on vagal pathway.

Sci Rep 2020 Jun 19;10(1):9986. Epub 2020 Jun 19.

Nutrition, Gut & Brain Unit (INSERM U1073), Institute for Biomedical Research and innovation, Rouen University, Rouen, France.

Ghrelin is the only orexigenic peptide currently known and a potent prokinetic by promoting gastric motility but novel insights suggest that its role extends beyond satiety regulation. Whereas ghrelin was shown to provide somatic and colonic antinociception, its impact on gastric sensitivity is unknown even though stomach is a major ghrelin secreting tissue. Autonomic response to gastric mechanosensitivity was estimated by measuring blood pressure variation as a surrogate marker in response to gastric distension (GD) before and after ghrelin (or vehicle) administration. Read More

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http://dx.doi.org/10.1038/s41598-020-67053-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7305309PMC

Immunohistochemical study of morphology and distribution of CD163 macrophages in the normal adult equine gastrointestinal tract.

Vet Immunol Immunopathol 2020 May 27;226:110073. Epub 2020 May 27.

The Royal (Dick) School of Veterinary Studies and The Roslin Institute, University of Edinburgh, Edinburgh, United Kingdom.

Intestinal macrophages are the largest group of mononuclear phagocytes in the body and play a role in intestinal innate immunity, neuroimmune interactions and maintaining intestinal homeostasis. Conversely, they also are implicated in numerous pathologies of the gastrointestinal tract, such as postoperative ileus and inflammatory bowel disease. As a result, macrophages could be potential therapeutic targets. Read More

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http://dx.doi.org/10.1016/j.vetimm.2020.110073DOI Listing

The High-Resolution Three-Dimensional Magnetic Detector System 3D-Magma Accurately Measures Gastric and Small Bowel Motility in People with Type 2 Diabetes with Neuropathy.

Exp Clin Endocrinol Diabetes 2020 Jun 18. Epub 2020 Jun 18.

Department of Internal Medicine IV (Gastroenterology, Hepatology and Infectious Diseases), Jena University Hospital, Jena, Germany.

Gastroparesis is an important complication of diabetes. Motility disorders are underdiagnosed and can lead to unexplained hypoglycemia. Currently diagnostic options are limited. Read More

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http://dx.doi.org/10.1055/a-1163-7230DOI Listing

Associations among neurophysiology measures in irritable bowel syndrome (IBS) and their relevance for IBS symptoms.

Sci Rep 2020 Jun 17;10(1):9794. Epub 2020 Jun 17.

Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Abnormal gut-brain interactions are common in irritable bowel syndrome (IBS), but the associations between neurophysiological measures and their relation to gastrointestinal (GI) symptoms are poorly understood. Our aim was to explore these relationships and define the most relevant neurophysiology measures for GI symptom severity in IBS. IBS patients underwent small intestinal motility (manometry; fasted and fed contraction frequency, phase III time) and secretion (transmural potential difference), rectal sensorimotor (barostat; sensory thresholds, tone response, compliance), autonomic nervous system (baroreceptor sensitivity and effectiveness), and colonic motor function (transit time) examinations. Read More

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http://dx.doi.org/10.1038/s41598-020-66558-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7300023PMC

Clinical experience of use of C-breath tests in oesophagogastroduodenal diseases: selective questions.

Prz Gastroenterol 2020 1;15(2):126-130. Epub 2019 Dec 1.

Department of Internal Medicine No. 1, Bogomolets National Medical University, Kyiv, Ukraine.

Introduction: Motility disorders can be an important factor in the occurrence of symptoms of dyspepsia that consequently require evaluation of clinical significance of noninvasive diagnostic approaches when observing patients with functional dyspepsia (FD), gastroesophageal reflux disease (GERD), and -associated diseases of the stomach and duodenum.

Aim: To determine the relationship between various motility disorders and to improve the diagnostics and treatment with the use of C-urea (UBT) and C-octanoic breath tests (OBT).

Material And Methods: A total of 591 patients, aged 18-83 years, who underwent upper gastrointestinal endoscopy at our department were evaluated. Read More

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http://dx.doi.org/10.5114/pg.2019.90080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294975PMC
December 2019

RADIOGRAPHIC DETERMINATION OF GASTRIC EMPTYING AND GASTROINTESTINAL TRANSIT TIME IN COWNOSE RAYS () AND WHITESPOTTED BAMBOO SHARKS () AND THE EFFECT OF METOCLOPRAMIDE ON GASTROINTESTINAL MOTILITY.

J Zoo Wildl Med 2020 Jun;51(2):326-333

Department of Animal Care, Mystic Aquarium, Mystic, CT 06355, USA.

Gastrointestinal (GI) pathology is common in elasmobranchs; however, information regarding normal GI transit time and the effect of therapeutics on GI motility is lacking. The objective of this study was to determine baseline gastric emptying and GI transit times in cownose rays () and whitespotted bamboo sharks () via radiographic barium sulfate contrast studies. Additionally, a pilot study was undertaken to determine the effect of metoclopramide on GI transit time in whitespotted bamboo sharks. Read More

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http://dx.doi.org/10.1638/2019-0015DOI Listing

Gut barrier proteins mediate liver regulation by the effects of serotonin on the non-alcoholic fatty liver disease.

Curr Protein Pept Sci 2020 Jun 15. Epub 2020 Jun 15.

State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193. China.

Serotonin (5-hydroxytryptamine, 5-HT) has been recognized as a potent pro-inflammatory mediator. Increasing the bioavailability and preventing the formation of 5-HT can reduce the inflammatory response in the body. Moreover, 5-HT is considered as an important central physiologic mediator of intestinal function by regulating intestinal motility, permeability and other functions. Read More

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http://dx.doi.org/10.2174/1389203721666200615171928DOI Listing

Ethnic differences in genetic polymorphism associated with irritable bowel syndrome.

World J Gastroenterol 2020 May;26(17):2049-2063

Department of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.

Genetic polymorphism is associated with irritable bowel syndrome (IBS) in terms of susceptibility and clinical manifestations. Previous studies have shown that genetic polymorphism might play a key role in the onset and progression of IBS by modulating components of its pathogenesis such as the gut-brain axis, gastrointestinal motility, inflammatory activity, and immune status. Although underlying pathophysiological mechanisms have not been fully clarified, the potential ethnic differences that are present in worldwide genetic studies of IBS deserve attention. Read More

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http://dx.doi.org/10.3748/wjg.v26.i17.2049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7267697PMC

[Gastrointestinal complications of liver cirrhosis].

Authors:
X R Yin D F Chen

Zhonghua Gan Zang Bing Za Zhi 2020 May;28(5):377-380

Department of Gastroenterology, Daping Hospital, Army Military Medical University, Chongqing 400042, China.

Liver cirrhosis is the end-stage of chronic liver disease and can affect the function of multiple organs. Gastrointestinal tract damage resulting from cirrhosis is more common in clinic, which may cause gastroparesis, affect the digestion and absorption of nutrients, and destroy the intestinal mucosal barrier function. In addition, it may be accompanied by a series of gastrointestinal complications that affect the patient's prognosis. Read More

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http://dx.doi.org/10.3760/cma.j.cn501113-20200413-00179DOI Listing

Human milk oligosaccharide supplementation in irritable bowel syndrome patients: A parallel, randomized, double-blind, placebo-controlled study.

Neurogastroenterol Motil 2020 Jun 14:e13920. Epub 2020 Jun 14.

Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Objectives: Human milk oligosaccharides safely and beneficially impact bifidobacteria abundance in healthy adults, while their effects in patients with irritable bowel syndrome (IBS) are unknown. Hence, we aimed to determine the dose of 4:1 mix of 2'-O-fucosyllactose and Lacto-N-neotetraose (2'FL/LNnT) that increases fecal bifidobacteria abundance without aggravating overall gastrointestinal symptoms in IBS patients in a randomized, double-blind, controlled study. Additionally, the impact of 2'FL/LNnT on the fecal bacterial profile was assessed. Read More

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http://dx.doi.org/10.1111/nmo.13920DOI Listing

Multi-target Treatment for Irritable Bowel Syndrome with STW 5: Pharmacological Modes of Action.

J Gastrointestin Liver Dis 2020 Jun 3;29(2):227-233. Epub 2020 Jun 3.

Servicio Aparato Digestivo, Centro Médico Teknon, Barcelona, Spain.

Irritable bowel syndrome (IBS) is a heterogeneous and complex functional gastrointestinal disorder with a global prevalence of approximately 11% and high geographic variation. IBS encompasses various symptom clusters considered to reflect complex patho-etiological mechanisms, and effective treatment options are limited, with most medications targeting individual mechanisms and symptoms. Therefore, multi-targeted treatment is required. Read More

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http://dx.doi.org/10.15403/jgld-814DOI Listing

Association Between Cannabis Use and Healthcare Utilization in Patients With Irritable Bowel Syndrome: A Retrospective Cohort Study.

Cureus 2020 May 7;12(5):e8008. Epub 2020 May 7.

Internal Medicine, John H. Stroger, Jr. Hospital of Cook County, Chicago, USA.

Introduction Irritable bowel syndrome (IBS) is a frequent cause of abdominal pain and altered bowel habits, which is associated with significant healthcare utilization. The effects of the active compound of cannabis, Δ9-tetrahydrocannabinol (THC), on gut motility and tone have been studied in several experimental models. It is unknown whether these effects correlate with improved healthcare utilization among cannabis users. Read More

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http://dx.doi.org/10.7759/cureus.8008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7279677PMC

Vitamin A deficiency exacerbates autism-like behaviors and abnormalities of the enteric nervous system in a valproic acid-induced rat model of autism.

Neurotoxicology 2020 Jun 8;79:184-190. Epub 2020 Jun 8.

Children's Nutrition Research Center, Children's Hospital of Chongqing Medical University, Chongqing Key Laboratory of Child Nutrition and Health, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorder, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing, China. Electronic address:

The manifestations of autism spectrum disorder (ASD) are highly heterogeneous. As many individuals with ASD have gastrointestinal (GI) comorbidities, ASD with GI problems is considered to be a subtype of ASD. Vitamin A (VA) plays an important role in the development of both the central and peripheral nervous system. Read More

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http://dx.doi.org/10.1016/j.neuro.2020.06.004DOI Listing

Persian herbal medicine in functional dyspepsia: a systematic review article.

Curr Drug Discov Technol 2020 Jun 11. Epub 2020 Jun 11.

Gastroenterology and Hepatology Research Center, Kerman University of Medical Sciences, Kerman. Iran.

Introduction: According to Rome IV, functional dyspepsia is diagnosed with presence of dyspepsia in the absence of organic or metabolic causes. FD caused by several factors such as impaired gastric accommodation and hypersensitivity to gastric distention. Several studies have reported effectiveness of herbal medicine on FD. Read More

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http://dx.doi.org/10.2174/1570163817666200611132831DOI Listing

European Society for Neurogastroenterology and Motility recommendations for conducting gastrointestinal motility and function testing in the recovery phase of the COVID-19 pandemic.

Neurogastroenterol Motil 2020 07;32(7):e13930

Department of Digestive Diseases and Internal Medicine, University of Bologna, St Orsola-Malpighi Hospital, Bologna, Italy.

Background: During the peak of the COronaVIrus Disease 2019 (COVID-19) pandemic, care for patients with gastrointestinal motility and functional disorders was largely suspended. In the recovery phases of the pandemic, non-urgent medical care is resumed, but there is a lack of guidance for restarting and safely conducting motility and function testing. Breath tests and insertion of manometry and pH-monitoring probes carry a risk of SARS-CoV-2 spread through droplet formation. Read More

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http://dx.doi.org/10.1111/nmo.13930DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7300574PMC

Total glucosides of paeony (TGP) alleviates constipation and intestinal inflammation in mice induced by Sjögren's syndrome.

J Ethnopharmacol 2020 Jun 7;260:113056. Epub 2020 Jun 7.

State Key Laboratory of Natural Medicines, School of Basic Medical Sciences and Clinical Pharmacy, China Pharmaceutical University, Nanjing, 210009, PR China. Electronic address:

Ethnopharmacological Relevance: Sjögren's syndrome (SS) is an autoimmune disease and can cause gastrointestinal disorders such as constipation and intestinal inflammation. As a kind of medicinal material, Paeonia lactiflora Pall has a variety of pharmacological effects, and it is also an indispensable component in many pharmaceutical preparations, which has been widely concerned by the medical and pharmaceutical circles. Total glucosides of paeony (TGP) is a mixture of biologically active compounds extracted from the root of Paeonia lactiflora Pall and has therapeutic effects on a variety of autoimmune diseases. Read More

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http://dx.doi.org/10.1016/j.jep.2020.113056DOI Listing
June 2020
2.998 Impact Factor

Safety of Thiopurine Use in Paediatric Gastrointestinal Disease.

J Pediatr Gastroenterol Nutr 2020 Jun 9. Epub 2020 Jun 9.

Neurogastroenterology and Motility Unit, UCL Great Ormond Street Institute for Child Health and Great Ormond Street Hospital, London, United Kingdom.

Thiopurines, alone or in combination with other agents, have a pivotal role in the treatment of specific gastrointestinal and hepatological disorders. In inflammatory bowel disease and autoimmune hepatitis thiopurines have proven their value as steroid sparing agents for the maintenance of remission and may be considered for preventing postoperative Crohn's disease recurrence where there is moderate risk of this occuring. Their use with infliximab therapy reduces antibody formation and increases biologic drug levels. Read More

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http://dx.doi.org/10.1097/MPG.0000000000002802DOI Listing

Interleukins 4 and 13 and Their Receptors Are Differently Expressed in Gastrointestinal Tract Cancers, Depending on the Anatomical Site and Disease Advancement, and Improve Colon Cancer Cell Viability and Motility.

Cancers (Basel) 2020 Jun 4;12(6). Epub 2020 Jun 4.

Department of Medical Biochemistry, Wroclaw Medical University, 50-368 Wroclaw, Poland.

Immunosuppressive interleukins (IL)-4 and 13 may directly promote cancer but neither their status nor role in gastrointestinal tract is clarified. We aim at quantifying ILs and their receptors in paired normal-tumor samples ( = 49/51) and sera ( = 263), using immunoassays and RTqPCR, and screening for their effect on colonic cancer cells. Both ILs were elevated locally at protein level in all cancers but only transcripts in colon were upregulated. Read More

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http://dx.doi.org/10.3390/cancers12061463DOI Listing

Small intestinal dysmotility in cirrhotic patients: correlation with severity of liver disease and cirrhosis-associated complications.

Z Gastroenterol 2020 Jun 8. Epub 2020 Jun 8.

Department of Gastroenterology, Hepatology and Gastrointestinal Oncology, Bogenhausen Academic Teaching Hospital, Technical University of Munich, Munich, Germany.

Introduction:  Altered small intestinal motility has been observed in various manometry studies in patients with cirrhosis. Since small bowel manometry is available only in a few centers, interpretation of dysmotility in cirrhosis is controversial.

Patients And Methods:  In this study, both fasting and postprandial manometric tracings of 24-hour antroduodenojejunal manometries were analyzed using both visual analysis and computer-aided analysis. Read More

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http://dx.doi.org/10.1055/a-1162-0357DOI Listing

Gallstone Disease and Microbiome.

Microorganisms 2020 Jun 2;8(6). Epub 2020 Jun 2.

Laboratory of Gastroenterology, Research Institute of Internal and Preventive Medicine-Branch of The Federal Research Center Institute of Cytology and Genetics of Siberian Branch of Russian Academy of Sciences, Novosibirsk 630089, Russia.

Gallstone disease (GSD) has, for many years, remained a high-cost, socially significant public health problem. Over the past decade, a number of studies have been carried out-both in humans and in animal models-confirming the role of the microbiota in various sections of the gastrointestinal tract as a new link in the etiopathogenesis of GSD. The microbiome of bile correlates with the bacterial composition of saliva, and the microbiome of the biliary tract has a high similarity with the microbiota of the duodenum. Read More

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http://dx.doi.org/10.3390/microorganisms8060835DOI Listing

Digestive involvement in a patient with Lambert-Eaton syndrome.

Rev Esp Enferm Dig 2020 Jun;112(6):510-511

UGC Aparato Digestivo, Hospital Universitario Clínico San Cecilio.

We present the case of a 50-year-old male diagnosed with myasthenia gravis, secondary to thymoma or Lambert-Eaton syndrome during the study of repeated vomiting. Gastrointestinal symptoms persisted despite the treatment of the thymoma. He suffered from sigma volvulus that required sigmoidectomy 9 years after diagnosis. Read More

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http://dx.doi.org/10.17235/reed.2020.6846/2019DOI Listing

Epidemiology and outcomes of gastroparesis, as documented in general practice records, in the United Kingdom.

Gut 2020 Jun 3. Epub 2020 Jun 3.

Leeds Institute of Medical Research at St. James's, University of Leeds, Leeds, UK.

Objective: To generate real-world evidence for the epidemiology of gastroparesis in the UK, we evaluated the prevalence, incidence, patient characteristics and outcomes of gastroparesis in the Clinical Practice Research Datalink (CPRD) database.

Design: This was a retrospective, cross-sectional study. Prevalence and incidence of gastroparesis were evaluated in the CPRD database, with linkage to Hospital Episodes Statistics Admitted Patient Care and Office for National Statistics mortality data. Read More

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http://dx.doi.org/10.1136/gutjnl-2020-321277DOI Listing

Prevalence and Predictors of Gastrointestinal Dysmotility in Patients with Hypermobile Ehlers-Danlos Syndrome: A Tertiary Care Center Experience.

Cureus 2020 Apr 29;12(4):e7881. Epub 2020 Apr 29.

Gastroenterology, Cleveland Clinic Florida, Weston, USA.

Introduction Ehlers-Danlos syndrome (EDS), specifically the hypermobility type (hEDS), is associated with a variety of gastrointestinal (GI) conditions. This study aims to evaluate the prevalence of and factors associated with gut dysmotility in patients with hEDS. Methods This is a retrospective study of hEDS patients conducted at the Cleveland Clinic's Center for Personalized Genetic Healthcare between January 2007 and December 2017. Read More

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http://dx.doi.org/10.7759/cureus.7881DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7255528PMC

Characterizing the proximal esophageal segment in patients with symptoms of esophageal dysmotility.

Neurogastroenterol Motil 2020 Jun 2:e13888. Epub 2020 Jun 2.

Gastroenterology Section, Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, USA.

Background: Proximal esophageal striated muscle contractility may be abnormal in patients with esophageal symptoms, but is not assessed in the Chicago Classification (CC) v3.0. We aimed to (a) determine the prevalence of abnormal proximal esophageal contractility in patients with esophageal symptoms; (b) compare proximal esophageal contractility in patients with different esophageal motility disorders; (c) assess the association of abnormal proximal esophageal contractility with esophageal symptoms. Read More

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http://dx.doi.org/10.1111/nmo.13888DOI Listing

Autism-associated synaptic mutations impact the gut-brain axis in mice.

Brain Behav Immun 2020 May 30. Epub 2020 May 30.

School of Health and Biomedical Sciences, RMIT University, Bundoora, VIC, Australia. Electronic address:

Interactions between the gut microbiome and the brain affect mood and behaviour in health and disease. Using preclinical animal models, recent discoveries begin to explain how bacteria in the gut influence our mood as well as highlighting new findings relevant to autism. Autism-associated gene mutations known to alter synapse function in the CNS also affect inflammatory response and modify the enteric nervous system resulting in abnormal gastrointestinal motility and structure. Read More

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http://dx.doi.org/10.1016/j.bbi.2020.05.072DOI Listing

Caspase-11-mediated enteric neuronal pyroptosis underlies Western diet-induced colonic dysmotility.

J Clin Invest 2020 Jul;130(7):3621-3636

Division of Digestive Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.

Enteric neuronal degeneration, as seen in inflammatory bowel disease, obesity, and diabetes, can lead to gastrointestinal dysmotility. Pyroptosis is a novel form of programmed cell death but little is known about its role in enteric neuronal degeneration. We observed higher levels of cleaved caspase-1, a marker of pyroptosis, in myenteric ganglia of overweight and obese human subjects compared with normal-weight subjects. Read More

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http://dx.doi.org/10.1172/JCI130176DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324173PMC

Kindlin-2 deficiency induces fatal intestinal obstruction in mice.

Theranostics 2020 15;10(14):6182-6200. Epub 2020 May 15.

Department of Human Anatomy, Histology and Embryology, Key Laboratory of Carcinogenesis and Translational Research, Ministry of Education, and State Key Laboratory of Natural and Biomimetic Drugs, Peking University Health Science Center, Beijing 100191, China.

: Smooth muscle-motility disorders are mainly characterized by impaired contractility and functional intestinal obstruction. Some of these cases are caused by genetic mutations of smooth muscle genes ACTA2, ACTG2, MYH11, MYLK and LMOD1. Still the etiology is complex and multifactorial and the underlying pathology is poorly understood. Read More

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http://dx.doi.org/10.7150/thno.46553DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7255029PMC
May 2020
7.827 Impact Factor

Experience with Esophago-Gastro-Intestinal Transit Scintigraphy - Initial 229 patients: Multiple Regions of Dysmotility are Common.

J Nucl Med 2020 Jun 1. Epub 2020 Jun 1.

Johns Hopkins University, United States.

The purpose of this investigation was to review our experience with our "Comprehensive Gastrointestinal Transit Study" in the first 229 patients. This scintigraphic study analyzes motility of the entire gut, from esophagus through the rectosigmoid colon. Data were reviewed for our first two years of experience (184 females, 45 males), age 20-79 (mean 44±16) with this exam. Read More

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http://dx.doi.org/10.2967/jnumed.120.243527DOI Listing

A survey on the impact of the COVID-19 pandemic on motility and functional investigations in Europe and considerations for recommencing activities in the early recovery phase.

Neurogastroenterol Motil 2020 07;32(7):e13926

Translational Research Center for Gastrointestinal Disorders (TARGID), Department of Chronic Diseases, Metabolism and Ageing (CHROMETA), KU Leuven, Leuven, Belgium.

Background: The COVID-19 pandemic, declared by WHO on March 13, 2020, had a major global impact on the healthcare system and services. In the acute phase, the presence of the SARS-CoV-2 virus in the aerodigestive tract limited activities in the gastroenterology clinic and procedures to emergencies only. Motility and function testing was interrupted and as we enter the recovery phase, restarting these procedures requires a safety-focused approach with adequate infection prevention for patients and healthcare professionals. Read More

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http://dx.doi.org/10.1111/nmo.13926DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7300498PMC

Effects and mechanisms of acupuncture and electroacupuncture for functional dyspepsia: A systematic review.

World J Gastroenterol 2020 May;26(19):2440-2457

Division of Gastroenterology and Hepatology, Johns Hopkins University School of Medicine, Baltimore, MD 21224, United States.

Background: Functional dyspepsia (FD) is a common digestive disease with limited therapeutic options. According to evidence-based clinical practice, acupuncture or electroacupuncture (EA) seems to be a promising therapy for patients with FD. However, there is still a lack of systematic reviews that have analyzed current clinical trials for a better understanding of mechanisms involved in the ameliorating effect of acupuncture and EA on FD. Read More

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http://dx.doi.org/10.3748/wjg.v26.i19.2440DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243644PMC
May 2020
2.369 Impact Factor

Gastroparesis: New insights into an old disease.

World J Gastroenterol 2020 May;26(19):2333-2348

Gastroenterology and Hepatology Section, Department of Medicine, University of Perugia Medical School, Perugia 06123, Italy.

Gastroparesis (Gp) is a chronic disease characterized by a delayed gastric emptying in the absence of mechanical obstruction. Although this condition has been reported in the literature since the mid-1900s, only recently has there been renewed clinical and scientific interest in this disease, which has a potentially great impact on the quality of life. The aim of this review is to explore the pathophysiological, diagnostic and therapeutical aspects of Gp according to the most recent evidence. Read More

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http://dx.doi.org/10.3748/wjg.v26.i19.2333DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243643PMC

Motor dysfunction of the gut in cystic fibrosis.

Neurogastroenterol Motil 2020 May 31:e13883. Epub 2020 May 31.

Digestive System Research Unit, University Hospital Vall d'Hebron; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (Ciberehd), Barcelona, Spain.

Background: Cystic fibrosis (CF) is a multisystem disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) protein. Cystic fibrosis transmembrane conductance regulator is extensively expressed in the intestine and has an important role in the regulation of the viscosity and pH of gut secretions. Several studies have reported a delay in small bowel and colonic transit times in patients with CF which have been attributed to the secretory dysfunction. Read More

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http://dx.doi.org/10.1111/nmo.13883DOI Listing

Idiopathic myenteric ganglionitis as a cause of death in a young male patient with sudden abdominal pain: an autopsy case report.

Int J Colorectal Dis 2020 May 30. Epub 2020 May 30.

Division of Human Pathology, Department of Pathology and Microbiology, Nihon University School of Medicine, Tokyo, Japan.

Background: Myenteric ganglionitis is a disorder that causes intestinal motor dysfunction. It may be caused due to neoplastic, central nervous system, or systemic infectious disorders. However, some cases are considered to be idiopathic in origin. Read More

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http://dx.doi.org/10.1007/s00384-020-03631-wDOI Listing

Volumetric analysis of small bowel motility in an unselected cohort of patients with Crohn's disease.

Neurogastroenterol Motil 2020 May 29:e13909. Epub 2020 May 29.

Department of Internal Medicine, Skåne University Hospital, Lund University, Malmö, Sweden.

Background: Quantified terminal ileal motility during magnetic resonance enterography (MRE) has been suggested to be used as a biomarker of Crohn's disease (CD). The aim of the present study was to evaluate this method in clinical practice.

Methods: Healthy volunteers and all consecutive patients referred to MRE during a 2-year period were asked to participate and complete the Irritable Bowel Syndrome-Symptom Severity Scale (IBS-SSS) to assess gastrointestinal symptoms. Read More

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http://dx.doi.org/10.1111/nmo.13909DOI Listing

Network Pharmacology and Bioactive Equivalence Assessment Integrated Strategy Driven Q-markers Discovery for Da-Cheng-Qi Decoction to Attenuate Intestinal Obstruction.

Phytomedicine 2020 Jul 18;72:153236. Epub 2020 May 18.

Key Laboratory of Drug Quality Control and Pharmacovigilance (Ministry of Education), State Key Laboratory of Natural Medicine, China Pharmaceutical University, Nanjing 210009, P. R. China. Electronic address:

Background: Intestinal obstruction (IO) is a kind of acute abdomen with high morbidity and mortality. Patients suffer from poor quality of life and tremendous financial pressure. Da-Cheng-Qi decoction (DCQD), a classical purgation prescription, has clinically been proven to be an effective treatment for IO. Read More

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http://dx.doi.org/10.1016/j.phymed.2020.153236DOI Listing
July 2020
3.126 Impact Factor

Endoscopic management of gastrointestinal motility disorders - part 2: European Society of Gastrointestinal Endoscopy (ESGE) Guideline.

Endoscopy 2020 Jul 27;52(7):600-614. Epub 2020 May 27.

Department of Gastroenterology, Dudley Group NHS Foundation Trust and Birmingham City University, Birmingham, UK.

ESGE suggests flexible endoscopic treatment over open surgical treatment as first-line therapy for patients with a symptomatic Zenker's diverticulum of any size.Weak recommendation, low quality of evidence, level of agreement 100 %.ESGE recommends that emerging treatments for Zenker's diverticulum, such as Zenker's peroral endoscopic myotomy (Z-POEM) and tunneling, be considered as experimental; these treatments should be offered in a research setting only. Read More

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http://dx.doi.org/10.1055/a-1171-3174DOI Listing