843 results match your criteria Intestinal Leiomyosarcoma


Ileal leiomyosarcoma presenting with intussusception.

J Surg Case Rep 2019 Feb 19;2019(2):rjz052. Epub 2019 Feb 19.

Department of Abdominal Surgery, University Medical Centre Ljubljana, Zaloška 7, SI-1525 Ljubljana, Slovenia.

Intussusception is a rare cause of small bowel obstruction in adults, up to 30% of cases are caused by small bowel malignancy. Intestinal leiomyosarcoma is an extremely rare malignant mesenchymal tumour. An 80-year-old male presented with small bowel obstruction. Read More

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http://dx.doi.org/10.1093/jscr/rjz052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380073PMC
February 2019
1 Read

Jejunal leiomyosarcoma: Report of a rare case diagnosed on cytology.

Diagn Cytopathol 2019 May 21;47(5):498-502. Epub 2018 Dec 21.

Department of Radiodiagnosis and Interventional Radiology, AIIMS, Jodhpur, India.

Jejunal leiomyosarcomas (LMS) are extremely rare. Of all the mesenchymal tumors of the small intestine, Gastrointestinal Stromal Tumors (GIST) comprise the majority. LMS of the small intestine have been documented as isolated reports or only a very small percentage of the smooth muscle tumors of the small intestine. Read More

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http://doi.wiley.com/10.1002/dc.24136
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http://dx.doi.org/10.1002/dc.24136DOI Listing
May 2019
11 Reads

A case of gastric leiomyosarcoma in a domestic shorthair cat.

JFMS Open Rep 2018 Jul-Dec;4(2):2055116918818912. Epub 2018 Dec 6.

Department of Internal Medicine, Highcroft Veterinary Referrals, Bristol, UK.

Case Summary: A 10-year-old male neutered domestic shorthair cat presented with nausea and 1.2 kg weight loss over a 6 month period. Physical examination was unremarkable, and haematological and biochemical results were considered clinically unremarkable. Read More

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http://dx.doi.org/10.1177/2055116918818912DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6293366PMC
December 2018
1 Read

Resection of a Perirectal Leiomyosarcoma via a Posterior Transcoccygeal Approach.

Ann Surg Oncol 2018 Sep 6;25(9):2641. Epub 2018 Jul 6.

Department of Surgical Oncology, MD Anderson Cancer Center, Houston, TX, USA.

Introduction: The management of perirectal tumors often requires rectal wall resection, and sometimes a complete proctectomy is required. Access to posterior perirectal masses via a posterior, transcoccygeal approach (Kraske procedure) avoids dissection of the intraperitoneal rectum.

Patient: The patient was a 63-year-old male who presented to his primary care physician with debilitating perirectal pain of several months' duration. Read More

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http://dx.doi.org/10.1245/s10434-018-6636-xDOI Listing
September 2018
25 Reads

Effect of Double-Balloon Enteroscopy on Diagnosis and Treatment of Small-Bowel Diseases.

Chin Med J (Engl) 2018 Jun;131(11):1321-1326

Department of Gastroenterology, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, Shandong 264000, China.

Background: The diagnosis and treatment of small-bowel diseases is clinically difficult. The purpose of this study was to evaluate the diagnostic and therapeutic value of double-balloon enteroscopy in small-bowel diseases.

Methods: The history and outcomes of 2806 patients who underwent double-balloon enteroscopy from July 2004 to April 2017 were reviewed, which included 562 patients with obscure digestive tract bleeding, 457 patients with obscure diarrhea, 930 patients with obscure abdominal pain, 795 patients with obscure weight loss, and 62 patients with obscure intestinal obstruction. Read More

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http://dx.doi.org/10.4103/0366-6999.232802DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987504PMC
June 2018
7 Reads

Endometrial Stromal Sarcoma With Hyalinizing Giant Rosettes, Mimicking Low-Grade Fibromyxoid Sarcoma.

Int J Surg Pathol 2018 Sep 6;26(6):525-527. Epub 2018 Apr 6.

1 Royal Marsden Hospital, London, UK.

We highlight a rare variant pattern of low-grade endometrial stromal sarcoma showing extensive collagenous rosette formation, closely mimicking low-grade fibromyxoid sarcoma. Additionally, this neoplasm showed diffuse and strong expression of muscle markers, favoring an initial diagnosis of leiomyosarcoma. Reverse transcription-polymerase chain reaction showed the presence of JAZF1-SUZ12 fusion transcripts, and this highlights the broad morphologic and immunophenotypic spectrum of endometrial stromal sarcoma. Read More

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http://dx.doi.org/10.1177/1066896918767547DOI Listing
September 2018
18 Reads

Radiation-induced leiomyosarcoma of the rectum after cervical cancer treatment.

Rev Gastroenterol Mex 2018 Oct - Dec;83(4):465-467. Epub 2018 Feb 10.

Departamento de Piel y Partes Blandas, Instituto Nacional de Cancerología, Ciudad de México, México.

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http://dx.doi.org/10.1016/j.rgmx.2017.06.001DOI Listing

[A Case of Leiomyosarcoma of the Small Intestine with Intestinal Hemorrhage Due to Intraluminal Penetration].

Gan To Kagaku Ryoho 2017 Nov;44(12):1068-1070

Dept. of Surgery, Tohoku University Graduate School of Medicine.

A 40-year-old man was referred to our hospital because of severe anemia and small intestinal tumor revealed by computed tomography. The enteroscopy exam showed the intraluminal penetration of the tumor, which was considered as a cause of anemia. Although emergency operation was performed laparoscopically, intraoperative findings indicated tumor invasion into peritoneum, and we converted from laparoscopic surgery to open surgery that included concomitant peritoneum resection. Read More

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November 2017
14 Reads

Spontaneous rupture of uterine smooth muscle tumour presenting acute abdominal pain and haemoperitoneum.

BMJ Case Rep 2018 Jan 3;2018. Epub 2018 Jan 3.

Chiba Aiyukai Memorial Hospital, Chiba, Japan.

Uterine smooth muscle tumours are histologically categorised into benign leiomyoma, malignant leiomyosarcoma or smooth muscle tumours of uncertain malignant potentials (STUMPs). Common symptoms of uterine tumours are hypermenorrhea, dysmenorrhea, lumbago or irregular genital bleeding. We experienced a case of uterine tumour with atypical clinical behaviour. Read More

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http://dx.doi.org/10.1136/bcr-2017-222806DOI Listing
January 2018
5 Reads

Leiomyomatosis peritonealisis disseminata: Two unusual cases with literature review.

J Gynecol Obstet Hum Reprod 2018 Feb 28;47(2):89-94. Epub 2017 Nov 28.

Chirurgie digestive, CHU de Caen, 14000 Caen, France.

Background: Leiomyomatosis peritonealis disseminata (LPD) is a rare benign disease characterized by numerous smooth muscle-like cell nodules disseminated among the abdominal cavity. The pathogenesis of LPD is not well-known; one hypothesis, widely reported, is parasitic LPD (after uterine myoma surgery). The role of hormonal status has been raised without any evidence yet confirmed. Read More

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http://dx.doi.org/10.1016/j.jogoh.2017.11.011DOI Listing
February 2018
1 Read

Surgical Management of Primary Retroperitoneal Sarcomas: Rationale for Selective Organ Resection.

Ann Surg Oncol 2018 Jan 24;25(1):98-106. Epub 2017 Oct 24.

Department of Surgery, Brigham and Women's Hospital, Boston, MA, USA.

Background: Recently, some have argued for routine resection of adjacent but uninvolved organs in patients with retroperitoneal sarcoma (RPS) without stipulating the rationale for such organ resection (beyond the need to achieve a macroscopically complete resection) or examining histopathologic organ invasion (HOI). This study reviewed the authors' experience with primary RPS to investigate the rate and rationale for individual organ resection and the rate of HOI.

Methods: Operative and pathology reports for patients with primary RPS who underwent resection at our institution were retrospectively reviewed. Read More

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http://dx.doi.org/10.1245/s10434-017-6136-4DOI Listing
January 2018
7 Reads

Integrated genome analysis of uterine leiomyosarcoma to identify novel driver genes and targetable pathways.

Int J Cancer 2018 03 7;142(6):1230-1243. Epub 2017 Nov 7.

Department of Oncology, Gynecologic Oncology, KU Leuven (University of Leuven), Leuven, 3000, Belgium.

Uterine leiomyosarcomas (uLMS) are rare, aggressive malignancies for which limited treatment options are available. To gain novel molecular insights into uLMS and identify potential novel therapeutic targets, we characterized 84 uLMS samples for genome-wide somatic copy number alterations, mutations, gene fusions and gene expression and performed a data integration analysis. We found that alterations affecting TP53, RB1, PTEN, MED12, YWHAE and VIPR2 were present in the majority of uLMS. Read More

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http://dx.doi.org/10.1002/ijc.31129DOI Listing
March 2018
20 Reads

Rare case of primary leiomyosarcoma of sigmoid mesocolon.

BMJ Case Rep 2017 Sep 15;2017. Epub 2017 Sep 15.

Department of Surgery, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia.

We experienced a rare case of primary leiomyosarcoma of sigmoid mesentery. A 45-year-old woman was presented to us with left iliac fossa mass and discomfort for 4-month duration. CT scan of abdomen and pelvis revealed a huge mass 14 cm×14 cm×16 cm occupying left iliac fossa mimicked having a large left ovarian carcinoma. Read More

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http://dx.doi.org/10.1136/bcr-2017-219826DOI Listing
September 2017
2 Reads

Pediatric liver transplantation for hepatocellular cancer and rare liver malignancies: US multicenter and single-center experience (1981-2015).

Liver Transpl 2017 12;23(12):1577-1588

Thomas E. Starzl Transplantation Institute, Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, PA.

A tenth of all pediatric liver transplantations (LTs) are performed for unresectable liver malignancies, especially the more common hepatoblastoma (HBL). Less understood are outcomes after LT for the rare hepatocellular carcinoma, nonhepatoblastoma embryonal tumors (EMBs), and slow growing metastatic neuroendocrine tumors of childhood. Pediatric LT is increasingly performed for rare unresectable liver malignancies other than HBL. Read More

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http://dx.doi.org/10.1002/lt.24847DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5725660PMC
December 2017
46 Reads

Synchronous coexistence of liver metastases from cecal leiomyosarcoma and rectal adenocarcinoma: A case report.

World J Gastroenterol 2017 Mar;23(9):1725-1734

Hideki Aoki, Takashi Arata, Masashi Utsumi, Yutaka Mushiake, Tomoyoshi Kunitomo, Isao Yasuhara, Fumitaka Taniguchi, Koh Katsuda, Kohji Tanakaya, Hitoshi Takeuchi, Department of Surgery, Iwakuni Clinical Center, Yamaguchi 740-8510, Japan.

Multiple liver tumors represent a challenging condition for abdominal surgeons both in the selection of technique and the rarity of diagnosis. There are no case reports on co-existence of liver metastases from both intestinal leiomyosarcoma and adenocarcinoma. The patient described in this report successfully underwent resection of both primary lesions and liver metastases in combination with chemotherapy. Read More

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http://www.wjgnet.com/1007-9327/full/v23/i9/1725.htm
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http://dx.doi.org/10.3748/wjg.v23.i9.1725DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5340824PMC
March 2017
15 Reads

A rare case of small bowel leiomyosarcoma presenting with acute gastro-intestinal bleeding.

BJR Case Rep 2017 22;3(2):20160089. Epub 2016 Dec 22.

Department of Radiology, Medisch Centrum Haaglanden, The Hague, Netherlands.

A 62-year-old Turkish female was admitted to our hospital with acute, progressive melena. Gastroscopy and colonoscopy could not reveal the cause of the melena. Subsequent CT angiography demonstrated a large, exophytic mass in the ileocecal junction as a source of the haemorrhage, leading to urgent laparotomy and resection. Read More

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https://www.birpublications.org/doi/10.1259/bjrcr.20160089
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http://dx.doi.org/10.1259/bjrcr.20160089DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6159237PMC
December 2016
8 Reads

[A pseudotumoral lesion revealing Meckel's diverticulum].

Arch Pediatr 2016 Nov 28;23(11):1157-1160. Epub 2016 Sep 28.

Service d'anatomie et cytologie pathologiques, hôpital Armand-Trousseau, AP-HP, 26, avenue du Dr-Arnold-Netter, 75012 Paris, France.

Introduction: Meckel's diverticulum is a common malformation in children, usually asymptomatic, with complications in only 20% of cases. Exceptionally, a tumor can develop in Meckel's diverticulum in children, particularly Burkitt's lymphoma; in adults it can develop into a gastrointestinal stromal tumor, a leiomyosarcoma, or a neuroendocrine tumor such as a carcinoid tumor. The diagnosis of inflammatory pseudotumor following an insidious perforation is rare. Read More

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http://dx.doi.org/10.1016/j.arcped.2016.08.002DOI Listing
November 2016
35 Reads

Unusual evolution of leiomyosarcoma of the rectum: a case report and review of the literature.

J Med Case Rep 2016 Sep 15;10(1):249. Epub 2016 Sep 15.

Department of Radiotherapy, National Institute of Oncology, University Mohammed V, Rabat, Morocco.

Background: Leiomyosarcoma of the rectum is a rare entity that comprises less than 0.1 % of all rectal malignancies. Given the uncommon nature of this tumor and the controversy about its treatment we report one case and review the literature in an attempt to report a particular evolution and to discuss the most appropriate treatment. Read More

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http://dx.doi.org/10.1186/s13256-016-1047-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5025574PMC
September 2016
2 Reads

A very rare case of a small bowel leiomyosarcoma leading to ileocaecal intussusception treated with a laparoscopic resection: a case report and a literature review.

World J Surg Oncol 2016 Feb 24;14(1):48. Epub 2016 Feb 24.

Department of General, Gastroenterological and Oncologic Surgery, Medical University of Warsaw, ul. Banacha 1a, 02-097, Warsaw, Poland.

Background: Small bowel tumours are rare and comprise less than 2% of all primary gastrointestinal neoplasms. Among these tumours, a leiomyosarcoma belonging to soft tissue sarcomas is extremely rare and accounts for about 1 % of malignant mesenchymal lesions in the gastrointestinal tract. Due to its aggressive nature and slow growth, it is often diagnosed at the late stage when curative treatment is impossible. Read More

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http://www.wjso.com/content/14/1/48
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http://dx.doi.org/10.1186/s12957-016-0798-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4765121PMC
February 2016
13 Reads

Gastrointestinal (GI) leiomyosarcoma (LMS) case series and review on diagnosis, management, and prognosis.

Med Oncol 2016 Feb 20;33(2):20. Epub 2016 Jan 20.

Department of Internal Medicine, Naef K. Basile Cancer Institute, American University of Beirut Medical Center, Beirut, Lebanon.

This review of 76 gastrointestinal (GI) leiomyosarcoma (LMS) cases that include 11 cases from the American University of Beirut Medical Center represents, to our knowledge, the largest number of combined GI LMS cases reported. The age range of GI LMS is variable, and the presentation is non-specific, making pathological diagnosis essential. LMSs usually lack CD117 and CD 34 mutations and are usually positive for smooth muscle cell markers. Read More

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http://dx.doi.org/10.1007/s12032-016-0730-3DOI Listing
February 2016
11 Reads

Laparoscopic Hysterectomy for Uterine Fibroids: Is it Safe?

Clin Obstet Gynecol 2016 Mar;59(1):66-72

*Department of Obstetrics and Gynecology †Division of Minimally Invasive Gynecologic Surgery, Brigham and Women's Hospital, Boston, Massachusetts.

As more complex cases and larger uterine specimens are able to be managed with minimally invasive surgery, the limitations of tissue retrieval with these methods are of increasing concern. Risks of morcellator-related injury, tissue dissemination, or fragmentation must be weighed against increased morbidity of abdominal approach to hysterectomy. In an effort to mitigate the risks of tissue morcellation, containment system use must be considered when fragmenting a specimen, either with power morcellation or a manual technique via the vagina or minilaparotomy. Read More

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http://dx.doi.org/10.1097/GRF.0000000000000165DOI Listing
March 2016
5 Reads

Clinical presentation and management of gastro-intestinal and pancreatic secondary metastatic tumors.

J BUON 2015 Jul-Aug;20(4):1009-14

2nd Department of Surgery, "Aretaieio" Hospital, University of Athens Medical School, Athens, Greece.

Purpose: As progress regarding the treatment has occurred over recent years in oncology, more patients with metastatic disease are presented for diagnosis and further management. The purpose of this study was to reveal the incidence, location and to describe the clinical characteristics and outcome in a series of patients diagnosed with pancreatic, small and large bowel metastatic tumors that underwent metastasectomy.

Methods: A total of 12 patients (7 male and 5 female) diagnosed with extrahepatic gastrointestinal (GI) and pancreatic metastases from 2001 to 2013 were operated for resection of secondary metastatic tumors to the small and large bowel and the pancreas. Read More

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November 2015
36 Reads
0.710 Impact Factor

Perineal approach for surgical treatment in a patient with retro-rectal tumor: a case report and review of the literature.

BMC Res Notes 2015 Sep 24;8:470. Epub 2015 Sep 24.

Department of Digestive Surgery, Faculty of Medicine and Pharmacy, Mohammed V Military Hospital, Mohammed V University, Rabat, Morocco.

Background: Retrorectal tumors in adults are very rare and little known condition. These tumors, often misdiagnosed or mistreated, should be completely excised because of the potential for malignancy or infection. A suitable operative approach is the key to the successful surgical management. Read More

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http://dx.doi.org/10.1186/s13104-015-1457-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4581409PMC
September 2015
9 Reads

[Cancer and wall growths in the mesenchymal gastrointestinal tract].

Pol J Pathol 2014 Dec;65(4 Suppl 1):S90-106

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December 2014
5 Reads

Gastrointestinal stromal tumour presenting as palpable abdominal mass: A rare entity.

World J Gastrointest Surg 2015 Jun;7(6):98-101

Manoj R Bhambare, Jayashri S Pandya, Sudatta B Waghmare, Tilakdas S Shetty, Department of General Surgery, Topiwala National Medical College and Bai Yamunabai Laxman Nair Hospital, Mumbai 400008, India.

Gastrointestinal stromal tumours (GISTs) are the most common mesenchymal tumour of gastro-intestinal tract. Annual incidence of GIST in United States is approximately 3000-4000. Clinical presentation of GIST varies with location and size of tumour but GIST presenting with palpable abdominal mass is rare. Read More

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http://dx.doi.org/10.4240/wjgs.v7.i6.98DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4478562PMC
June 2015
8 Reads

Sinonasal inflammatory myofibroblastic pseudotumor (plasma cell granuloma).

Kulak Burun Bogaz Ihtis Derg 2015 ;25(3):174-8

Department of Pathology, Medical Faculty of Mersin University, 33100 Zeytinlibahçe, Mersin, Turkey.

Inflammatory myofibroblastic pseudotumor (plasma cell granuloma) is a soft tissue lesion consisting of myofibroblasts, mature lymphocytes, histiocytes, plasma cells, eosinophils, and extracellular collagen. Various sites in the body may harbor these lesions. Lungs, omentum, intestines, mesentery, and urinary system are the most susceptible areas. Read More

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http://dx.doi.org/10.5606/kbbihtisas.2015.04875DOI Listing
June 2016
7 Reads

Diaphragm disease of the small intestine: an interesting case report.

Int J Surg Pathol 2015 Jun 18;23(4):322-4. Epub 2014 Dec 18.

Airedale Hospital, Steeton, UK.

Diaphragm disease of small intestine usually presents with nonspecific clinical features. Radiological investigations often fail to differentiate it from small intestinal tumors and inflammatory bowel disease. It is therefore diagnosed on final histology after surgical resection. Read More

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http://dx.doi.org/10.1177/1066896914563392DOI Listing
June 2015
9 Reads

What is your diagnosis? Leiomyosarcoma.

J Am Vet Med Assoc 2015 Jan;246(1):51-3

Center for Veterinary Health Sciences, College of Veterinary Medicine, Oklahoma State University, Stillwater, OK 74078.

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http://avmajournals.avma.org/doi/abs/10.2460/javma.246.1.51
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http://dx.doi.org/10.2460/javma.246.1.51DOI Listing
January 2015
5 Reads

Small intestinal gastrointestinal stromal tumor in a young adult woman: a case report and review of the literature.

J Med Case Rep 2014 Sep 28;8:321. Epub 2014 Sep 28.

Institute of Pathology, Faculty of Medicine, University of Prishtina, Mother Theresa Street NN, 10 000 Prishtina, Kosovo.

Introduction: Gastrointestinal stromal tumor is the most common sarcoma of the gastrointestinal tract. We report a case of gastrointestinal stromal tumor in a small intestine, initially suspected for leiomyosarcoma given that gastrointestinal stromal tumors in young adult patients are limited due to their rarity.

Case Presentation: A 30-year-old Caucasian ethnic Albanian woman from Kosovo presented with abdominal pain, nausea and vomiting. Read More

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http://www.jmedicalcasereports.com/content/pdf/1752-1947-8-3
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http://www.jmedicalcasereports.com/content/8/1/321
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http://dx.doi.org/10.1186/1752-1947-8-321DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4188407PMC
September 2014
17 Reads

Metastasis of gastrointestinal stromal tumor to skeletal muscle: a case report.

J Med Case Rep 2014 Jul 18;8:256. Epub 2014 Jul 18.

Department of Orthopaedic Surgery, University of Toyama, 2630 Sugitani, Toyama, Toyama 930-0194, Japan.

Introduction: Gastrointestinal stromal tumor is the most common malignant mesenchymal tumor of the gastrointestinal tract. The most common sites of metastasis are the liver and the peritoneum, but gastrointestinal stromal tumors rarely metastasize to the skeletal muscles. Only three cases of gastrointestinal stromal tumor metastasizing to skeletal muscle have been reported in the English literature. Read More

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http://dx.doi.org/10.1186/1752-1947-8-256DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4112972PMC
July 2014
5 Reads

Bowel perforation associated with temsirolimus use in a recently irradiated patient.

Am J Health Syst Pharm 2014 Jun;71(11):919-23

Claire M. Mach, Pharm.D., is Assistant Professor, College of Pharmacy, University of Houston, and Division of Gynecologic Oncology, Baylor College of Medicine, Houston, TX. Anze Urh, M.D., is Obstetrics and Gynecology Resident, Division of Gynecologic Oncology, Baylor College of Medicine. Matthew L. Anderson, M.D., Ph.D., is Assistant Professor and Director of Clinical and Translational Research, Division of Gynecologic Oncology and Dan L. Duncan Cancer Center, Baylor College of Medicine.

Purpose: A probable case of bowel perforation associated with temsirolimus use in a patient with uterine leiomyosarcoma is reported.

Summary: A 45-year-old Hispanic woman reported acute abdominal pain one day after receiving her third weekly i.v. Read More

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http://dx.doi.org/10.2146/ajhp130145DOI Listing
June 2014
4 Reads

Idiopathic phlebosclerotic colitis: a rare entity of chronic ischemic colitis.

Korean J Gastroenterol 2014 Mar;63(3):183-6

Department of Internal Medicine, Hanyang University College of Medicine, 222 Wangsimni-ro, Seongdong-gu, Seoul 133-791, Korea.

Colonic wall thickening is frequently encountered in various conditions, from acute or chronic inflammatory disease to colorectal carcinoma. Colonic wall thickening may be accompanied by calcifications in mucinous adenocarcinoma of the colon, leiomyosarco-ma of the colon, schistosomiasis japonica, and phlebosclerotic colitis. Phlebosclerotic colitis is a rare entity of chronic ischemic colitis associated with sclerosis and fibrosis of mesenteric veins. Read More

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March 2014
11 Reads

A case of benign schwannoma of the ascending colon treated with laparoscopic-assisted wedge resection.

Int Surg 2013 Oct-Dec;98(4):315-8

1 Department of Surgery, Korea University Anam Hospital, Seoul, Korea.

Isolated colonic schwannomas are rare gastrointestinal mesenchymal tumors. Only a small number of cases have been reported. Occurrence of these tumors is more common in the stomach than in the large intestine. Read More

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http://dx.doi.org/10.9738/INTSURG-D-13-00015.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3829056PMC
February 2015
8 Reads

[Colonic intussusception by leiomyosarcoma].

Rev Gastroenterol Peru 2013 Jul-Sep;33(3):251-4

Departamento del Aparato Digestivo, Hospital Nacional Edgardo Rebagliati Martins, EsSalud. Lima, Perú.

Unlabelled: We report the case of female patient, 34 years old, occupation Secretary.

Background: Polycystic ovary and chronic anemia. No family history of cancer. Read More

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August 2014
7 Reads

Gastrointestinal leiomyosarcoma in a pygmy sperm whale (Kogia breviceps).

J Zoo Wildl Med 2013 Sep;44(3):744-8

Department of Infectious Diseases and Pathology, College of Veterinary Medicine, University of Florida, Gainesville, Florida 32612, USA.

An adult male pygmy sperm whale (Kogia breviceps) was stranded within a tidal pool on Fernandina Beach on the north Florida Atlantic coast (USA) and expired soon after discovery. Necropsy findings included a small intestinal mass markedly expanding the intestinal wall and partially obstructing the lumen. This finding likely led to the malnutrition and ultimately the stranding of this whale. Read More

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http://dx.doi.org/10.1638/2012-0147R.1DOI Listing
September 2013
13 Reads

Leiomyosarcoma of the sigmoid colon: a rare cause of intestinal intussusception.

J Gastrointest Cancer 2014 Dec;45 Suppl 1:6-9

Department of Gastroenterology, Pforzheim Hospital, Kanzlerstr. 2-6, 75175, Pforzheim, Germany,

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http://dx.doi.org/10.1007/s12029-013-9520-8DOI Listing
December 2014
10 Reads

Patient with two secondary somatic-type malignancies in a late recurrence of a testicular non-seminoma: illustration of potential and flaw of the cancer stem cell therapy concept.

Int J Dev Biol 2013 ;57(2-4):153-7

Department of Pathology, Erasmus University Medical Center, Daniel den Hoed Cancer Center, Rotterdam, The Netherlands.

Here, we report the case of a patient with a non-seminoma of the left testicle, with an intestinal-type adenocarcinoma and a low grade leiomyosarcoma in a late recurrence 19 years after initial diagnosis. The history of the patient, alive with disease 21 years after initial treatment, illustrates the potential and flaw of the cancer stem cell therapy concept. In addition, it is proposed that residual mature teratoma can be regarded as normalization of cancer due to embryonic patterning, and the development of a secondary somatic-type malignancy as failure of normalization. Read More

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http://dx.doi.org/10.1387/ijdb.130141joDOI Listing
January 2014
11 Reads

Presence of adenovirus species C in infiltrating lymphocytes of human sarcoma.

PLoS One 2013 6;8(5):e63646. Epub 2013 May 6.

Leibniz Institute for Experimental Virology, Department of Molecular Virology, Hamburg, Germany.

Human adenoviruses are known to persist in T-lymphocytes of tonsils, adenoids and intestinal tract. The oncogenic potential of different adenovirus types has been widely studied in rodents, in which adenovirus inoculation can induce multiple tumors such as undifferentiated sarcomas, adenocarcinomas and neuroectodermal tumors. However, the oncogenic potential of this virus has never been proven in human subjects. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0063646PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3646006PMC
December 2013
4 Reads

Primary leiomyosarcoma of the mesentery in two sisters: clinical and molecular characteristics.

Pol J Pathol 2013 Apr;64(1):59-63

Department of Biology and Genetics, Medical University of Gdansk, Poland.

Mesenteric leiomyosarcoma (LMS) is a very rare malignancy whose familiar occurrence has not yet been reported. We present two sisters who developed intestinal LMS. Pathological analysis of the tumor samples, including evaluation of smooth muscle actin+, desmin+, Myf4-, DOG-1-, S100-, CD34- and CD117- confirmed LMS diagnosis. Read More

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http://www.termedia.pl/Journal/-55/pdf-20617-10?filename=Pri
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April 2013
9 Reads

Genomic analysis and selected molecular pathways in rare cancers.

Phys Biol 2012 Dec 29;9(6):065004. Epub 2012 Nov 29.

Norris Comprehensive Cancer Center, Division of Medical Oncology, University of Southern California, Los Angeles, CA, USA.

It is widely accepted that many cancers arise as a result of an acquired genomic instability and the subsequent evolution of tumor cells with variable patterns of selected and background aberrations. The presence and behaviors of distinct neoplastic cell populations within a patient's tumor may underlie multiple clinical phenotypes in cancers. A goal of many current cancer genome studies is the identification of recurring selected driver events that can be advanced for the development of personalized therapies. Read More

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http://dx.doi.org/10.1088/1478-3975/9/6/065004DOI Listing
December 2012
5 Reads

Primary small bowel malignancy: a 10-year clinical experience from Southern Taiwan.

Hepatogastroenterology 2013 Jun 16;60(124):756-8. Epub 2012 Nov 16.

Background/aims: The difficulty in establishing early definitive diagnosis and treatment of primary small bowel malignancy (PSBM) is a challenge for clinicians. This study aimed to analyze the symptomatology, diagnosis and outcomes of PSBM.

Methodology: A retrospective chart review study was conducted on 49 patients who underwent surgical treatment for PSBM at a tertiary hospital between May 2000 and January 2010. Read More

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http://dx.doi.org/10.5754/hge12893DOI Listing
June 2013
4 Reads

Somatic MED12 mutations in uterine leiomyosarcoma and colorectal cancer.

Br J Cancer 2012 Nov 20;107(10):1761-5. Epub 2012 Sep 20.

Department of Medical Genetics, Genome-Scale Biology Research Program, University of Helsinki, PO Box 63, Helsinki FIN-00014, Finland.

Background: Mediator complex participates in transcriptional regulation by connecting regulatory DNA sequences to the RNA polymerase II initiation complex. Recently, we discovered through exome sequencing that as many as 70% of uterine leiomyomas harbour specific mutations in exon 2 of mediator complex subunit 12 (MED12). In this work, we examined the role of MED12 exon 2 mutations in other tumour types. Read More

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http://dx.doi.org/10.1038/bjc.2012.428DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493861PMC
November 2012
3 Reads

Inactivation of Patched1 in mice leads to development of gastrointestinal stromal-like tumors that express Pdgfrα but not kit.

Gastroenterology 2013 Jan 3;144(1):134-144.e6. Epub 2012 Oct 3.

Department of Human Genetics, University Medical Center, Göttingen, Germany.

Background & Aims: A fraction of gastrointestinal stromal tumor (GIST) cells overexpress the platelet-derived growth factor receptor (PDGFR)A, although most overexpress KIT. It is not known if this is because these receptor tyrosine kinases have complementary oncogenic potential, or because of heterogeneity in the cellular origin of GIST. Little also is known about why Hedgehog (HH) signaling is activated in some GIST. Read More

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http://dx.doi.org/10.1053/j.gastro.2012.09.061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4231777PMC
January 2013
14 Reads

Synchronous small bowel and atypical primary leiomyosarcoma of inferior vena cava in a patient with RB1 mutation.

Abdom Imaging 2014 Feb;39(1):33-9

Department of Radiology, Dana Farber Cancer Institute & Harvard Medical School, 450 Brookline Avenue, Boston, MA, 02215, USA,

A 72-year-old Caucasian man presenting with non-specific upper abdominal pain had asymmetric soft tissue thickening of the small bowel wall on computed tomography (CT), which was pathologically proven to be leiomyosarcoma (LMS). At the same time point patient had incidentally but retrospectively detected lesion in IVC on CT scan which was subsequently imaged with PET/CT and MRI and was histologically proven to be also LMS. We present clinical and imaging features along with pedigree of this unique case of synchronous primary LMS involving the small bowel and inferior vena cava in a patient with RB1 gene mutation and a significant family history of multiple malignancies. Read More

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http://dx.doi.org/10.1007/s00261-012-9904-4DOI Listing
February 2014
4 Reads

Ileal leiomyosarcoma and lymph node granuloma. Relevance of a rare association.

Clin Res Hepatol Gastroenterol 2012 Oct 21;36(5):e96-9. Epub 2012 Mar 21.

Service d'Anatomie Pathologique, Hopitaux Universitaires Paris Seine Saint-Denis, AP-HP, Bobigny, France.

Leiomyosarcoma is rare in ileal location. We report the case of a 61 years old female patient presenting with ileal leiomyosarcoma occurring at 14 years after a uterine carcinoma treated by radiotherapy. The ileal tumor was treated by surgical resection. Read More

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http://dx.doi.org/10.1016/j.clinre.2012.01.011DOI Listing
October 2012
3 Reads

Surgery for perforated small bowel malignancy: a single institution's experience over 4 years.

Surgeon 2012 Feb 1;10(1):6-8. Epub 2011 Feb 1.

Department of General Surgery, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, Singapore 308433, Singapore.

Introduction: Surgery for perforated small bowel malignancy is associated with dismal morbidity and mortality rates. The aim of the paper was to highlight our institution's surgical experience in the management of patients with malignant small bowel perforation.

Methods: A retrospective review of all patients who underwent operative intervention for malignant small bowel perforation from 2004 to 2007 was performed. Read More

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http://dx.doi.org/10.1016/j.surge.2010.12.003DOI Listing
February 2012
10 Reads

[A case report of huge abdominal recurrent tumor of small intestinal GIST after 15 years from the operation with primary lesion].

Gan To Kagaku Ryoho 2011 Nov;38(12):2208-10

Dept. of Surgery, Suita Municipal Hospital.

A man in his 60s was given an emergency operation 15 years ago for abdominal bleeding. His tumor of small intestine was resected and diagnosed as small intestinal leiomyosarcoma. He came to our hospital because of his abdominal masses 15 years after the initial operation. Read More

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November 2011
4 Reads

Duodenal gastrointestinal stromal tumor.

Rom J Morphol Embryol 2011 ;52(3 Suppl):1121-5

Nicolae Anestiadi First Department of Surgery and Laboratory of Hepato-Pancreato-Biliary Surgery, Nicolae Testemitanu Medical University, National Center of Emergency Medicine, Kishinev, Moldova.

Background: Gastrointestinal stromal tumors (GISTs) are low-grade malignant tumors that may arise anywhere in the alimentary tract, and in the past, most of them were diagnosed as intestinal leiomyoma or leiomyosarcoma. GISTs of the duodenum make up only 4.5% of all GISTs. Read More

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March 2012
5 Reads

[Leiomyosarcoma with prominent osteoclast-like giant cells: a clinicopathologic analysis of 7 cases and review of literature].

Zhonghua Bing Li Xue Za Zhi 2011 Jun;40(6):363-7

Department of Pathology, Shanghai Miedical College, Fudan University, Shanghai 200032, China.

Objective: To study the clinicopathologic features of leiomyosarcoma with prominent osteoclast-like giant cells.

Methods: The clinical and pathologic features of 7 cases of leiomyosarcoma with prominent osteoclast-like giant cells were analyzed. Immunohistochemical and ultrastructural studies were performed. Read More

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June 2011
5 Reads