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    Infection in Two Residents of Savannakhet Province, Lao PDR.
    Korean J Parasitol 2018 Feb 28;56(1):75-79. Epub 2018 Feb 28.
    Department of Parasitology, Korea University College of Medicine, Seoul 02841, Korea.
    Adult specimens of(Garrison, 1908) Odhner, 1911 (Trematoda: Echinostomatidae) were recovered from 2 riparian people who resided along the Mekong River in Savannakhet Province, Lao PDR. In fecal examinations done by the Kato-Katz technique, they revealed echinostome eggs together with eggs of(and minute intestinal fluke eggs) and hookworms. To recover the adult flukes, they were treated with praziquantel 30-40 mg/kg in a single dose and purged with magnesium salts. Read More

    Adaptation of the secretome of Echinostoma caproni may contribute to parasite survival in a Th1 milieu.
    Parasitol Res 2018 Feb 12. Epub 2018 Feb 12.
    Departamento de Parasitología, Facultad de Farmacia, Universidad de Valencia, Avda. Vicent Andrés Estellés s/n, Burjassot, 46100, Valencia, Spain.
    Echinostoma caproni (Trematoda: Echinostomatidae) is an intestinal trematode, broadly employed to study the host-dependent mechanisms that govern the evolution of intestinal helminth infections. Resistance against E. caproni homologous secondary infections has been reported in mice and appears to be related to the generation of a local Th2 response, whereas Th1 responses promote the development of chronic primary infections. Read More

    Diet assimilation trends and host-parasite relationships in two species of sunfish (Lepomis) revealed by stable isotope analyses of multiple tissues.
    Parasitol Res 2018 Feb 2. Epub 2018 Feb 2.
    Formerly School of Environmental Studies, Queen's University, Kingston, Ontario, Canada.
    White grub flukes, Posthodiplostomum minimum centrarchi (Trematoda), and hookworms Pomphorhynchus bulbocolli (Acanthocephala) are common internal parasites for many North American freshwater fishes. P. minimum are found as cysts in internal organ tissues, while P. Read More

    A new species of Steringotrema Odhner, 1911 (Trematoda: Fellodistomidae) from the New Zealand sole Peltorhamphus novaezeelandiae Günther off Kaka point in the Catlins, South Island, New Zealand.
    Syst Parasitol 2018 Mar 25;95(2-3):213-222. Epub 2018 Jan 25.
    Ecology Degree Programme, University of Otago, P.O. Box 56, Dunedin, 9054, New Zealand.
    As a part of a comprehensive survey of macroparasites of commercially exploited fish species off the coast of Otago, New Zealand, the parasite fauna of the New Zealand sole Peltorhamphus novaezeelandiae Günther was recently studied. Steringotrema robertpoulini n. sp. Read More

    A new genus and species of turtle blood fluke (Digenea: Schistosomatoidea) from the Mekong snail-eating turtle, Malayemys subtrijuga (Schlegel & Müller) (Testudines: Geoemydidae) in Vietnam, with a reassessment of related Asiatic turtle blood flukes and molecular phylogeny.
    Syst Parasitol 2018 Mar 22;95(2-3):133-145. Epub 2018 Jan 22.
    Aquaculture & Aquatic Sciences and Aquatic Parasitology Laboratory, School of Fisheries, Auburn University, 203 Swingle Hall, Auburn, AL, 36849, USA.
    Platt sinuosus Roberts & Bullard n. g., n. Read More

    Assessing the benefits of five years of different approaches to treatment of urogenital schistosomiasis: A SCORE project in Northern Mozambique.
    PLoS Negl Trop Dis 2017 12 8;11(12):e0006061. Epub 2017 Dec 8.
    Schistosomiasis Control Initiative, Department of Infectious Disease Epidemiology, Imperial College London, London, United Kingdom.
    Background: In Mozambique, schistosomiasis is highly endemic across the whole country. The Schistosomiasis Consortium for Operational Research and Evaluation (SCORE) coordinates a five-year study that has been implemented in various African countries, including Mozambique. The overall goal of SCORE was to better understand how to best apply preventive chemotherapy with praziquantel (PZQ) for schistosomiasis control by evaluating the impact of alternative treatment approaches. Read More

    Intestinal Parasite Infections among Inhabitants in Yanbian Prefecture, Jilin Province, China.
    Korean J Parasitol 2017 Oct 31;55(5):579-582. Epub 2017 Oct 31.
    Division of Vectors and Parasitic Diseases, Centers for Disease Control and Prevention, Osong 28159, Korea.
    To investigate the prevalence of intestinal parasite infections in Yanbian Prefecture, Jilin Province, China, epidemiological surveys were conducted on a collaboration basis between the Korean Centers for Disease Control and Prevention and the Yanbian Center for Disease Control and Prevention. A total of 8,396 (males 3,737 and females 4,659) stool samples were collected from 8 localities and examined with the formalin-ether sedimentation technique, and additionally examined with the cellotape anal swab to detect Enterobius vermicularis eggs. The overall rate of intestinal parasites was 1. Read More

    New Record of Aspidogaster ijimai Kawamura, 1913 (Trematoda: Aspidogastridae) from Cyprinus carpio in Korea.
    Korean J Parasitol 2017 Oct 31;55(5):575-578. Epub 2017 Oct 31.
    Department of Parasitology, Medical Research Institute and Parasite Resource Bank, Chungbuk National University School of Medicine, Cheongju 28644, Korea.
    Aspidogastrid trematodes (Subclass Aspidogastrea) are a relatively small group with a characteristic adhesive disc and parasitize in a variety of cold-blooded hosts. Until now, only 2 species in the genus Cotylaspis, i.e. Read More

    Molecular discrimination of Opisthorchis-like eggs from residents in a rural community of central Thailand.
    PLoS Negl Trop Dis 2017 Nov 2;11(11):e0006030. Epub 2017 Nov 2.
    Department of Microbiology, Faculty of Science, Mahidol University, Bangkok, Thailand.
    Background: Opisthorchis viverrini infection is a major public health problem in northern and northeastern Thailand. The chronic infection of O. viverrini is related to cholangiocarcinoma which causes high mortality in endemic areas. Read More

    Schistosoma mansoni: In vivo evaluation of Phyllanthus amarus hexanic and ethanolic extracts.
    Exp Parasitol 2017 Dec 23;183:56-63. Epub 2017 Oct 23.
    Biology Institute, Animal Biology Department, Campinas State University (UNICAMP), SP, Brazil. Electronic address:
    Human schistosomiasis is an important neglected tropical disease caused by blood flukes of the genus Schistosoma and is responsible for more than 280,000 deaths annually. Treatment for this disease relies currently on a single drug, praziquantel (PZQ). Concerns regarding PZQ resistance and insensitivity of juvenile schistosomes have increased the interest in resorting to medicinal plants for alternative drug therapies. Read More

    Cross-species prophylactic efficacy of Sm-p80-based vaccine and intracellular localization of Sm-p80/Sm-p80 ortholog proteins during development in Schistosoma mansoni, Schistosoma japonicum, and Schistosoma haematobium.
    Parasitol Res 2017 Nov 12;116(11):3175-3188. Epub 2017 Oct 12.
    Center for Tropical Medicine and Infectious Diseases, School of Medicine, Texas Tech University Health Sciences Center, Lubbock, TX, USA.
    Schistosomiasis remains a major global health problem. Despite large-scale schistosomiasis control efforts, clear limitations such as possible emergence of drug resistance and reinfection rates highlight the need for an effective schistosomiasis vaccine. Schistosoma mansoni large subunit of calpain (Sm-p80)-based vaccine formulations have shown remarkable efficacy in protecting against S. Read More

    [Food-borne trematodiases].
    Rev Med Suisse 2017 Oct;13(578):1741-1744
    Clinique de médecine, HFR Fribourg - Hôpital cantonal, 1708 Fribourg.
    Food-borne trematodiases (flukes) are transmitted through the consumption of contaminated undercooked aquatic food. Infections are most prevalent in Southeast Asia and Latin America, but might occur anywhere due to food trade, international travel, human migration. Clinical manifestations are hepatobiliary, intestinal, and pleuropulmonary. Read More

    Estimating sensitivity of the Kato-Katz technique for the diagnosis of Schistosoma mansoni and hookworm in relation to infection intensity.
    PLoS Negl Trop Dis 2017 Oct 4;11(10):e0005953. Epub 2017 Oct 4.
    Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland.
    The Kato-Katz technique is the most widely used diagnostic method in epidemiologic surveys and drug efficacy trials pertaining to intestinal schistosomiasis and soil-transmitted helminthiasis. However, the sensitivity of the technique is low, particularly for the detection of light-intensity helminth infections. Examination of multiple stool samples reduces the diagnostic error; yet, most studies rely on a single Kato-Katz thick smear, thus underestimating infection prevalence. Read More

    Helminth parasites of the endangered hooded grebe, Podiceps gallardoi, from Patagonia Argentina, with the description of two new digenean species.
    J Helminthol 2017 Oct 4:1-9. Epub 2017 Oct 4.
    División Zoología Invertebrados,Museo de La Plata,Facultad de Ciencias Naturales y Museo,Universidad Nacional de La Plata (UNLP),Paseo del Bosque S/N°, 1900 La Plata,Buenos Aires Province,Argentina.
    In March 2011, a predator killed 33 hooded grebes, Podiceps gallardoi Rumboll (Podicipedidae), a critically endangered species, in a nesting colony at El Cervecero Lake, Santa Cruz Province, Argentina. The viscera of ten birds were examined for helminths. Two new species of Trematoda were recovered from the intestines. Read More

    Immunolocalization and immunodetection of the excretory/secretory (ES) antigens of Fasciola gigantica.
    PLoS One 2017 3;12(10):e0185870. Epub 2017 Oct 3.
    Section of Parasitology, Department of Zoology, Aligarh Muslim University, Aligarh, India.
    The digenetic trematode Fasciola gigantica is a parasite of great agricultural and economic importance. Along with Fasciola hepatica, F. gigantica incurs huge economic losses to the agricultural sector. Read More

    Perceptions about interventions to control schistosomiasis among the Lake Victoria island communities of Koome, Uganda.
    PLoS Negl Trop Dis 2017 Oct 2;11(10):e0005982. Epub 2017 Oct 2.
    Social Aspects of Health Programme, Medical Research Council/ Uganda Virus Research Institute (MRC/ UVRI) Uganda Research Unit, Uganda Virus Research Institute, Entebbe, Uganda.
    Background: Praziquantel-based mass treatment is the main approach to controlling schistosomiasis mansoni in endemic areas. Interventions such as provision and use of safe water, minimising contact with infested water, disposal of stool in latrines and snail control provide key avenues to break the transmission cycle and can sustain the benefits of mass treatment in the long term. Efforts are also being made to develop a schistosomiasis vaccine which, if effective, might reduce the incidence of re-infection after treatment. Read More

    Evaluation of the pharmacokinetic-pharmacodynamic relationship of praziquantel in the Schistosoma mansoni mouse model.
    PLoS Negl Trop Dis 2017 Sep 21;11(9):e0005942. Epub 2017 Sep 21.
    Merck Global Health Institute, Ares Trading S.A., a subsidiary of Merck KGaA (Darmstadt, Germany), Coinsins, Switzerland.
    After more than 40 years of use, Praziquantel (PZQ) still remains the drug of choice for the treatment of intestinal and urogenital schistosomiasis. Its anti-parasitic activity resides primarily in the (R)-enantiomer. Hitherto neither the molecular target nor the pharmacokinetic-pharmacodynamic relationship have been fully elucidated. Read More

    A comparative study on the efficacy of praziquantel and albendazole in the treatment of urinary schistosomiasis in Adim, Cross River State, Nigeria.
    Int Health 2017 09;9(5):288-293
    Medical Microbiology/Parasitology Unit, Department of Medical Laboratory Science, University of Calabar, Cross River State, Nigeria.
    Background: Praziquantel (PZQ) is the current drug of choice for the treatment of urinary schistosomiasis in endemic areas. It is very efficacious, although the potential for the development of resistance has been reported in some endemic areas among human subjects and in animal studies. Its' limitation include high cost and administration of multiple numbers of tablets. Read More

    Characterization of Echinostoma cinetorchis endoribonuclease, RNase H.
    Korean J Parasitol 2017 Aug 31;55(4):451-455. Epub 2017 Aug 31.
    Institute of Research and Development, Scorpiogen Co., Anseong 17579, Korea.
    Echinostoma cinetorchis is an oriental intestinal fluke causing significant pathological damage to the small intestine. The aim of this study was to determine a full-length cDNA sequence of E. cinetorchis endoribonuclease (RNase H; EcRNH) and to elucidate its molecular biological characters. Read More

    Assessment of schistosomiasis and soil-transmitted helminths prevalence in school-aged children and opportunities for integration of control in local health services in Kwilu Province, the Democratic Republic of the Congo.
    Trop Med Int Health 2017 11 14;22(11):1442-1450. Epub 2017 Sep 14.
    Department of Public Health, Institute of Tropical Medicine Antwerp, Antwerp, Belgium.
    Objective: To determine the prevalence of schistosomiasis (SCH) and soil-transmitted helminths (STH) in the Democratic Republic of Congo, and to assess the capacity of the local health centres for diagnosis and treatment.

    Methods: Cross-sectional school-based survey in two health districts in the Province of Kwilu. We collected a stool and a urine sample for parasitological examination. Read More

    Metazoan parasites from odontocetes off New Zealand: new records.
    Parasitol Res 2017 Oct 10;116(10):2861-2868. Epub 2017 Aug 10.
    Department of Zoology, University of Otago, 340 Great King Street, PO Box 56, Dunedin, 9054, New Zealand.
    Information about the parasite fauna of spectacled porpoises and cetaceans from New Zealand waters in general is scarce. This study takes advantage of material archived in collections of the Otago Museum in Dunedin and Massey University in Auckland, sampled from cetacean species found stranded along the New Zealand coastline between 2007 and 2014. Parasites from seven species of cetaceans (spectacled porpoise, Phocoena dioptrica (n = 2 individuals examined); pygmy sperm whale (n = 1); long-finned pilot whale, Globicephala melas (n = 1); Risso's dolphin, Grampus griseus (n = 1); short-beaked common dolphin, Delphinus delphis (n = 7); striped dolphin, Stenella coeruleoalba (n = 3) and dusky dolphin, Lagenorhynchus obscurus (n = 2)) from the respiratory and gastro-intestinal tract, cranial sinus, liver, urogenital and mammary tract, fascia and blubber were investigated. Read More

    Tissue Lesions Due to Spirorchiid Eggs in a Loggerhead Turtle ( Caretta caretta Linnaeus 1758) from Brazil: First Report Outside of the United States.
    J Parasitol 2017 Dec 24;103(6):801-803. Epub 2017 Jul 24.
    Universidade Estadual do Norte Fluminense Darcy Ribeiro-UENF, Campos dos Goytacazes, Rio de Janeiro, 28013-602, Brazil.
    Spirorchiids (family Spirorchiidae Stunkard 1921) are a group of flukes that inhabit the circulatory system of turtles. Infection by members of the family Spirorchiidae involves egg deposition in the host bloodstream and accumulation in tissues, which cause inflammatory reactions and embolisms, leading or contributing to the death of the host. Reports of spirorchiid egg lesions in loggerhead turtles ( Caretta caretta Linnaeus, 1758) have only been reported from U. Read More

    : Metacercariae Encysted insp. Snails Purchased from Phnom Penh, Cambodia.
    Korean J Parasitol 2017 Jun 30;55(3):341-345. Epub 2017 Jun 30.
    Institute of Parasitic Diseases, Korea Association of Health Promotion, Seoul 07653, Korea.
    The metacercariae of(Leiper, 1911) Mendheim, 1943 were discovered insp. snails purchased from a market in Phnom Penh, Cambodia. They were isolated from the snails using the artificial digestion technique and were orally fed to 2 hamsters, 1 rat, and 2 mice to obtain the adult flukes. Read More

    A Case of Ectopic Peritoneal Paragonimiasis Mimicking Diverticulitis or Abdominal Abscess.
    Korean J Parasitol 2017 Jun 30;55(3):313-317. Epub 2017 Jun 30.
    Department of Infectious Diseases, Asan Medical Center, Seoul 05505, Korea.
    Paragonimiasis is a parasitic disease caused byspecies. The primary site of infection is the lung, and extrapulmonary involvement is also reported. When infected with, which is the dominant species in Korea, the central nervous system is frequently involved along with the liver, intestine, peritoneal cavity, retroperitoneum, and abdominal wall. Read More

    Antibody trapping: A novel mechanism of parasite immune evasion by the trematode Echinostoma caproni.
    PLoS Negl Trop Dis 2017 Jul 17;11(7):e0005773. Epub 2017 Jul 17.
    Departamento de Parasitología, Facultad de Farmacia, Universidad de Valencia, Burjassot, Valencia, Spain.
    Background: Helminth infections are among the most prevalent neglected tropical diseases, causing an enormous impact in global health and the socioeconomic growth of developing countries. In this context, the study of helminth biology, with emphasis on host-parasite interactions, appears as a promising approach for developing new tools to prevent and control these infections.

    Methods/principal Findings: The role that antibody responses have on helminth infections is still not well understood. Read More

    Longitudinal survey on the distribution of Biomphalaria sudanica and B. choanomophala in Mwanza region, on the shores of Lake Victoria, Tanzania: implications for schistosomiasis transmission and control.
    Parasit Vectors 2017 Jun 28;10(1):316. Epub 2017 Jun 28.
    Department of Life Sciences, Natural History Museum, Cromwell Road, London, SW7 5BD, UK.
    Background: Schistosomiasis is hyper-endemic in the Lake Victoria basin; with intestinal schistosomiasis plaguing communities adjacent to the lake, where the intermediate host snails live. The two intermediate host species of Schistosoma mansoni in the Mwanza region are Biomphalaria sudanica, found on the banks of the lakes, and B. choanomphala, found in the lake itself. Read More

    High burden of Schistosoma mansoni infection in school-aged children in Marolambo District, Madagascar.
    Parasit Vectors 2017 Jun 24;10(1):307. Epub 2017 Jun 24.
    Ministère de la Santé Publique, Antananarivo, Madagascar.
    Background: A school-based survey was undertaken to assess prevalence and infection intensity of schistosomiasis in school-aged children in the Marolambo District of Madagascar.

    Methods: School-aged children from six purposively selected schools were tested for Schistosoma haematobium by urine filtration and Schistosoma mansoni using circulating cathodic antigen (CCA) and Kato-Katz stool analysis. The investigators did not address soil-transmitted helminths (STH) in this study. Read More

    Epidemiology of intestinal helminthiasis among school children with emphasis on Schistosoma mansoni infection in Wolaita zone, Southern Ethiopia.
    BMC Public Health 2017 06 20;17(1):587. Epub 2017 Jun 20.
    Aklilu Lemma Institute of Pathobiology, Addis Ababa University, Addis Ababa, Ethiopia.
    Background: Intestinal helminth infections are major parasitic diseases causing public health problems in Ethiopia. Although the epidemiology of these infections are well documented in Ethiopia, new transmission foci for schistosomiasis are being reported in different parts of the country. The objective of this study was to assess the prevalence of Schistosoma mansoni and other intestinal helminth infections among school children and determine the endemicity of schistosomiasis in Wolaita Zone, southern Ethiopia. Read More

    LAMPhimerus: A novel LAMP assay for detecting Amphimerus sp. DNA in human stool samples.
    PLoS Negl Trop Dis 2017 Jun 19;11(6):e0005672. Epub 2017 Jun 19.
    Infectious and Tropical Diseases Research Group (e-INTRO), Biomedical Research Institute of Salamanca-Research Centre for Tropical Diseases at the University of Salamanca (IBSAL-CIETUS), Faculty of Pharmacy, University of Salamanca, Salamanca, Spain.
    Background: Amphimeriasis is a fish-borne disease caused by the liver fluke Amphimerus spp. that has recently been reported as endemic in the tropical Pacific side of Ecuador with a high prevalence in humans and domestic animals. The diagnosis is based on the stool examination to identify parasite eggs, but it lacks sensitivity. Read More

    First record of a rare transversotrematid cercaria larva (Trematoda: Digenea) from Rajasthan, India: focus on seasonal occurrence and host-specificity of diverse cercariae.
    J Parasit Dis 2017 Jun 15;41(2):496-502. Epub 2016 Sep 15.
    Parasitology and Toxicology Research Laboratory, Post Graduate Department of Zoology, Government Meera Girls College, Udaipur, Rajasthan 313001 India.
    During the survey of freshwater snail hosts and their digenean larval trematode parasites, a rare cercaria larva belonging to family Transversotrematidae and subclass Digenea (Trematoda) was recovered from the snail speciesinhabiting perennial Som river of Udaipur district, Rajasthan, India. More than 28 % mature specimens of these snails were found to be infected with transversotrematid cercaria larvae in the spring season. Body of this cercaria is large, bowl-shaped, biocellate, spinose, transparent and laterally extended having two pigmented eye spots, two hold fast organs extended from the junction of body and tail, large tail with two foliated furcal rami, and cyclocoel intestinal caeca. Read More

    Intraspecific variation in adult Uvitellina iraquensis Dronen, Ali & Al-Amura, 2013 (Cyclocoelidae: Haematotrephinae) from two collection sites of white-tailed lapwing, Vanellus leucurus (Lichtenstein) (Charadriiformes: Charadriidae), in Iraq.
    Zootaxa 2017 Mar 9;4242(1):1-33. Epub 2017 Mar 9.
    Laboratory of Parasitology, Department of Wildlife and Fisheries Sciences, Texas A&M University, 2258 TAMU, College Station, Texas 77843-2258; USA..
    A total of 19 white-tailed lapwing, Vanellus leucurus, were collected from Huwazah Marsh, north-eastern Basrah Province, Iraq from February to March and in October, 2011 (collection site #1) and 60 V. leucurus were collected from Al-Hammar Marshes, Thi-Qar Province, southern Iraq from July to November, 2012 (collection site #2), and examined for cyclocoelids. Nineteen Uvitellina iraquensis Dronen, Ali & Al-Amura, 2013 from site #1 and 17 specimens from site #2 were fixed with minimal compression for comparisons of morphological characteristics, measurements, morphometric percentages and morphometric ratios commonly used to distinguish species of cyclocoelids. Read More

    The importance of patient compliance in repeated rounds of mass drug administration (MDA) for the elimination of intestinal helminth transmission.
    Parasit Vectors 2017 Jun 12;10(1):291. Epub 2017 Jun 12.
    London Centre for Neglected Tropical Disease Research, Department of Infectious Disease Epidemiology, St Mary's Campus, Imperial College London, London, W2 1PG, UK.
    Background: Systematic non-compliance to chemotherapeutic treatment among a portion of the eligible population is thought to be a major obstacle to the elimination of helminth infections by mass drug administration (MDA). MDA for helminths is repeated at defined intervals such as yearly or every 2 years, as a consequence of the inability of the human host to develop fully protective immunity to reinfection. As such, how an individual complies to these repeated rounds of MDA can have a significant impact on parasite transmission. Read More

    Redescription of Austrodiplostomum compactum (Trematoda: Diplostomidae) from its Type Host and Locality in Venezuela, and of Austrodiplostomum mordax from Argentina.
    J Parasitol 2017 Oct 10;103(5):497-505. Epub 2017 Jun 10.
    Departamento de Biodiversidad y Biología Experimental, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Pabellón II, 1428 Buenos Aires, Argentina.
    Austrodiplostomum compactum from Nannopterum brasilianus, and its metacercaria from Geophagus sp. and Oreochromis mossambicus captured (1979) at its type locality, Valencia Lake, Venezuela, by the author, are redescribed. The adult is characterized by its large body size, and an oral sucker smaller than the pharynx. Read More

    Present Situation of Opisthorchiasis in Vientiane Capital, Lao Peoples' Democratic Republic.
    Nihon Eiseigaku Zasshi 2017 ;72(2):101-105
    Graduate School of Nursing and Faculty of Nursing, Hiroshima Bunka Gakuen University.
    Opisthorchiasis is the commonest liver disease caused by Opisthorchis viverrini in Thailand, Lao People's Democratic Republic (PDR) and Cambodia, which will be a major cause of future human cholangiocarcinoma in these regions. In this short review, we describe the epidemic aspects of this parasite infection and the outline of results of our recent surveys of the fluke in humans and its intermediate hosts in Vientiane Capital, where information on the opisthorchiasis epidemic is insufficient. We examined the stool from a total of 296 persons living in the Phailom village (population, 1545, 1999) from 2011 to 2012. Read More

    Effects of dietary intake of garlic on intestinal trematodes.
    Parasitol Res 2017 Aug 23;116(8):2119-2129. Epub 2017 May 23.
    Departamento de Parasitología, Facultad de Farmacia, Universidad de Valencia, Avda. Vicent Andrés Estellés s/n, 46100, Burjassot, Valencia, Spain.
    The current strategy for the control of helminth infections relies on chemotherapy. However, resistance appearance is promoting the necessity of developing new drugs against trematodes. Herein, potential trematocidal effects of garlic (Allium sativum) are investigated in the context of intestinal foodborne trematodes, employing the Echinostoma caproni-mouse model. Read More

    Medicinal chemistry of antischistosomal drugs: Praziquantel and oxamniquine.
    Bioorg Med Chem 2017 07 27;25(13):3259-3277. Epub 2017 Apr 27.
    Laboratório de Química e Inovação Terapêutica (LQIT), Departamento de Antibióticos, Centro de Ciências Biológicas, Universidade Federal de Pernambuco (UFPE), Av. Prof. Moraes Rego s/n, Cidade Universitária, 50670-901 Recife, PE, Brazil. Electronic address:
    Neglected tropical diseases (NTDs) are a group of diseases that, besides prevailing in poverty conditions, contribute to the maintenance of social inequality, being a strong barrier to a country development. Schistosomiasis, a NTD, is a tropical and subtropical disease caused by the trematode Schistosoma mansoni (Africa, Middle East, Caribbean, Brazil, Venezuela, Suriname), japonicum (China, Indonesia, the Philippines), mekongi (several districts of Cambodia and the Lao People's Democratic Republic), intercalatum and guianensis (areas of tropical rainforests in Central Africa) and hematobium (Middle East Africa, Corsica, France) whose adult forms inhabit the mesenteric vessels of the host, while the intermediate forms are found in the aquatic gastropod snails of the genus Biomphalaria. Currently, praziquantel (PZQ) is the first line drug chosen for the treatment of schistosomiasis according to the World Health Organization (WHO) Model List of Essential Medicines, 2015. Read More

    Therapeutic effect of Schistosoma japonicum cystatin on bacterial sepsis in mice.
    Parasit Vectors 2017 May 8;10(1):222. Epub 2017 May 8.
    Basic Medical College of Bengbu Medical College, Bengbu, 233000, China.
    Background: Sepsis is a life-threatening complication of an infection and remains one of the leading causes of mortality in surgical patients. Bacteremia induces excessive inflammatory responses that result in multiple organ damage. Chronic helminth infection and helminth-derived materials have been found to immunomodulate host immune system to reduce inflammation against some allergic or inflammatory diseases. Read More

    Immunization with recombinant schistosome adenylate kinase 1 partially protects mice against Schistosoma japonicum infection.
    Parasitol Res 2017 Jun 28;116(6):1665-1674. Epub 2017 Apr 28.
    Hubei Province Key Laboratory of Allergy and Immunology, Department of Parasitology, Wuhan University School of Basic Medical Sciences, Wuhan, Hubei Province, 430071, China.
    Highly effective and safe prophylactic vaccines are urgently needed to sustainably control schistosomiasis, one of the most serious endemic zoonoses in China. In this study, we characterized adenylate kinase 1 from Schistosoma japonicum (SjAK1), a phosphotransferase that regulates cellular energy and metabolism, and evaluated its potential as a recombinant vaccine. Based on real-time quantitative PCR, western blot, and immunolocalization, SjAK1 is active throughout the life of the worm, although its expression is higher in 21-day-old schistosomula, adult worms, and eggs deposited in the host liver. Read More

    Pathology and molecular analysis of Hapalotrema mistroides (Digenea: Spirorchiidae) infecting a Mediterranean loggerhead turtle Caretta caretta.
    Dis Aquat Organ 2017 Apr;124(2):101-108
    Istituto Zooprofilattico Sperimentale del Mezzogiorno, Via Salute n. 2, 80055 Portici, Italy.
    Turtle blood flukes belonging to the family Spirorchiidae (Digenea) represent a major threat for sea turtle health and are considered the most important parasitic cause of turtle stranding and mortality worldwide. Despite the large diversity of spirorchiid species found globally, there are only 2 records for free-ranging Mediterranean sea turtles that date back to the late 1800s involving just Hapalotrema mistroides Monticelli, 1896. This study describes the first fatal confirmed case of spirorchiidiasis in a free-ranging Mediterranean loggerhead turtle Caretta caretta (Linnaeus) and, owing to the complexities of taxonomic identification of these parasites, provides the first molecular characterization and phylogenetic analysis of H. Read More

    Mathematical algorithm for the automatic recognition of intestinal parasites.
    PLoS One 2017 14;12(4):e0175646. Epub 2017 Apr 14.
    Unidad de Bioinformática, Laboratorios de Investigación y Desarrollo, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, Perú.
    Parasitic infections are generally diagnosed by professionals trained to recognize the morphological characteristics of the eggs in microscopic images of fecal smears. However, this laboratory diagnosis requires medical specialists which are lacking in many of the areas where these infections are most prevalent. In response to this public health issue, we developed a software based on pattern recognition analysis from microscopi digital images of fecal smears, capable of automatically recognizing and diagnosing common human intestinal parasites. Read More

    Clinical diagnostic value of viable Schistosoma japonicum eggs detected in host tissues.
    BMC Infect Dis 2017 04 4;17(1):244. Epub 2017 Apr 4.
    Molecular Parasitology Laboratory, Queensland Institution of Medical Research, Brisbane, QLD, Australia.
    Background: Schistosomiasis, one of the neglected tropical diseases, is endemic in more than 70 countries. However, the clinical diagnosis of patients with a low degree of infection is an unsolved technical problem. In areas endemic for schistosomiasis japonica, proctoscopy detection of eggs has been one method used for clinical diagnosis. Read More

    Rapid mapping of urinary schistosomiasis: An appraisal of the diagnostic efficacy of some questionnaire-based indices among high school students in Katsina State, northwestern Nigeria.
    PLoS Negl Trop Dis 2017 Apr 3;11(4):e0005518. Epub 2017 Apr 3.
    Department of Biological Sciences, Faculty of Science, Federal University Dutsinma, Dutsin-Ma, Katsina State, Nigeria.
    Background: In sub-Saharan Africa, over 200 million individuals are estimated to be infected with urinary and intestinal schistosomiasis. In a bid to lay a foundation for effective future control programme, this study was carried out with the aim of assessing the diagnostic efficacy of some questionnaire-based rapid assessment indices of urinary schistosomiasis.

    Methodology: A total number of 1,363 subjects were enrolled for the study. Read More

    Prevalence of Alaria infection in companion animals in north central Oklahoma from 2006 through 2015 and detection in wildlife.
    J Am Vet Med Assoc 2017 Apr;250(8):881-886
    OBJECTIVE To determine the prevalence of Alaria infection in cats and dogs in north central Oklahoma over various periods and investigate whether wild animal species in this region were also infected. DESIGN Combined cross-sectional study and case series. SAMPLE Results of parasitological testing of fecal samples from 5,417 client-owned dogs and 1,246 client-owned cats (2006 through 2014); fecal samples from 837 shelter or rescue dogs and 331 shelter or rescue cats (2013 and 2014) and 268 feral cats (2015); tongue or jowl samples from cadavers of 43 wild pigs, 3 opossums, and 1 raccoon; and intestinal tract segments from cadavers of 48 cats and 5 coyotes. Read More

    Immune response of rats vaccinated orally with various plant-expressed recombinant cysteine proteinase constructs when challenged with Fasciola hepatica metacercariae.
    PLoS Negl Trop Dis 2017 Mar 23;11(3):e0005451. Epub 2017 Mar 23.
    Witold Stefański Institute of Parasitology, Polish Academy of Sciences, Warsaw, Poland.
    Background: Cysteine proteinases of Fasciola hepatica are important candidates for vaccine antigens because of their role in fluke biology and host-parasite relationships. In our previous experiments, we found that a recombinant cysteine proteinase cloned from adult F. hepatica (CPFhW) can protect rats against liver fluke infections when it is administered intramuscularly or intranasally in the form of cDNA. Read More

    Oral delivery of Bacillus subtilis spores expressing cysteine protease of Clonorchis sinensis to grass carp (Ctenopharyngodon idellus): Induces immune responses and has no damage on liver and intestine function.
    Fish Shellfish Immunol 2017 May 18;64:287-296. Epub 2017 Mar 18.
    Department of Parasitology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China; Key Laboratory for Tropical Diseases Control, Sun Yat-sen University, Ministry of Education, Guangzhou, Guangdong, China; Provincial Engineering Technology Research Center for Biological Vector Control, Guangzhou, Guangdong 510080, China. Electronic address:
    Clonorchis sinensis (C. sinensis) is a fish-borne trematode. Human can be infected by ingestion of C. Read More

    Taxonomic tools for the identification ofgn. sp. (Digenea: Hemiuroidea: Derogenidae) fromof Rohilkhand, India based on light and scanning electron microscopic studies.
    J Parasit Dis 2017 Mar 16;41(1):29-39. Epub 2016 Mar 16.
    Department of Ecosystem Studies, School of Environmental Sciences, The University of Shiga Prefecture, 2500 Hassaka, Hikone, Shiga 522 8533 Japan.
    The stomach of the freshwater snakehead murrel,(n = 250) collected from fresh water habitats of Bareilly, Uttar Pradesh, India revealed, a trematode parasite (Plagiorchiida: Derogenidae). An illustrated account of light (Olympus BX-53 with Cellsens software imaging system) and scanning electron microscopy (SEM) (Neo JCM-6000) ofn. sp. Read More

    Crohn's disease and schistosomiasis: a rare association.
    Pan Afr Med J 2016 31;25:124. Epub 2016 Oct 31.
    University of Tunis El Manar, Faculty of Medicine of Tunis, 1007, Tunisia.
    Schistosomiasis is a chronic enteropathogenic disease caused by blood flukes of the genus Schistosoma. Coexistence of schistosomiasis with Crohn's disease is very rare. To the best of our knowledge, this association has been described in literature only once. Read More

    Phylogenetic analysis reveals cryptic species diversity within minute intestinal fluke, Stellantchasmus falcatus Onji and Nishio, 1916 (Trematoda, Heterophyidae).
    Asian Pac J Trop Med 2017 Feb 21;10(2):165-170. Epub 2017 Jan 21.
    Department of Biology, Faculty of Science, Chiang Mai University, Chiang Mai 50202, Thailand; Economic Plant Genome Service Centre, Faculty of Science, Chiang Mai University, Chiang Mai 50202, Thailand.
    Objective: To examine the taxonomic boundaries in the Stellantchasmus populations in different hosts and reveal the cryptic speciation of the Stellantchasmus in Thailand based on both morphological and molecular approaches.

    Methods: Stellantchasmus falcatus (S. falcatus) s. Read More

    Fasciolopsis buski (Digenea: Fasciolidae) from China and India may represent distinct taxa based on mitochondrial and nuclear ribosomal DNA sequences.
    Parasit Vectors 2017 Feb 22;10(1):101. Epub 2017 Feb 22.
    State Key Laboratory of Veterinary Etiological Biology, Key Laboratory of Veterinary Parasitology of Gansu Province, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu Province, 730046, People's Republic of China.
    Background: Fasciolopsis buski is a zoonotic intestinal fluke infecting humans and pigs, but it has been seriously neglected. It is yet to know whether there is any genetic diversity among F. buski from different geographical locations, particularly in sequences of nuclear ribosomal DNA (rDNA) and mitochondrial (mt) DNA. Read More

    Effects of anthelmintic treatment and feed supplementation on parasite infections and morbidity parameters in Cambodian cattle.
    Vet Parasitol 2017 Feb 22;235:113-122. Epub 2017 Jan 22.
    Department of Biomedical Sciences, Institute of Tropical Medicine, Nationalestraat 155, B-2000, Antwerpen, Belgium; Department of Virology, Parasitology and Immunology, Salisburylaan 133, B-9820, Merelbeke, Belgium. Electronic address:
    Helminth infections are the cause of morbidity in Cambodian cattle but other factors such as nutritional deficiencies and concurrent diseases may enhance the effects of parasites. The present study aimed to investigate the impact of anthelmintic treatment, feed supplementation, or both on gastrointestinal strongyle (GIS) and trematode infections as well as on morbidity parameters in Cambodian village cattle. At the beginning of the dry season, cattle populations in six villages were randomly assigned to a group: (A) receiving anthelmintic treatment (ivermectin+clorsulon) at week 0; (P) feed pellet supplementation during week 0-13 or both (AP). Read More

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