2,544 results match your criteria Intestinal Flukes
Int J Nanomedicine 2018 6;13:4493-4505. Epub 2018 Aug 6.
Department of Pharmaceutics, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt,
Purpose: Lipid nanocapsules (LNCs) have shown potential to increase the bioavailability and efficacy of orally administered drugs. However, their intestinal translocation to distal target sites and their implication in pharmacokinetic (PK)-pharmacodynamic (PD) relationships are yet to be elucidated. In this study, the effect of LNCs on the PD activity and pharmacokinetics of praziquantel (PZQ), the mainstay of schistosomiasis chemotherapy, was investigated. Read More
Nat Rev Dis Primers 2018 Aug 9;4(1):13. Epub 2018 Aug 9.
National Institute of Parasitic Diseases, Shanghai, People's Republic of China.
Schistosomiasis (bilharzia) is a neglected tropical disease caused by parasitic flatworms (blood flukes) of the genus Schistosoma, with considerable morbidity in parts of the Middle East, South America, Southeast Asia and, particularly, in sub-Saharan Africa. Infective larvae grow in an intermediate host (fresh-water snails) before penetrating the skin of the definitive human host. Mature adult worms reside in the mesenteric (Schistosoma mansoni and Schistosoma japonicum) or pelvic (Schistosoma haematobium) veins, where female worms lay eggs, which are secreted in stool or urine. Read More
Korean J Parasitol 2018 Jun 30;56(3):259-265. Epub 2018 Jun 30.
Infection Disease Intelligence Division, Gangwon Institute of Health and Environment, Chuncheon 24203, Korea.
To investigate the infection status of zoonotic trematode metacercariae in yellowfin goby, Acanthogobius flavimanus, from coastal areas of the Republic of Korea (Korea), we examined total 344 gobies from 21 localities with an artificial digestion method from 2013 to 2017. The metacercariae of Stictodora lari were most frequently detected in 45.3% goby from 7 localities, i. Read More
Int J Parasitol Parasites Wildl 2018 Apr 31;7(1):68-74. Epub 2018 Jan 31.
Natural History Museum of Geneva, PO Box 6434, CH-1211 Geneva 6, Switzerland.
The eye represents an immune privileged organ where parasites can escape host reactions. This study provides the first systematic evidence of the pathology associated with sp. infection in the eye retina of fish (i. Read More
Acta Parasitol 2018 Sep;63(3):586-594
Department of Parasitology, College of Veterinary Science and Animal Husbandry, Navsari Agricultural University, Navsari-396 450, Gujarat, India.
Morphological and molecular identification can pave the way to design the most effective control measures against the Paramphistomum epiclitum in small ruminants. Morphology of the flukes had described the features of Paramphistomum genus. Body was conical with concave ventral and convex dorsal surface, tegumental spines all around the body in the immature stage, terminal funnel shape oral sucker, sub-terminal acetabulum, blind caeca with a serpentine course touching the anterior level of the acetabulum. Read More
Rev Inst Med Trop Sao Paulo 2018 28;60:e26. Epub 2018 Jun 28.
Laboratório de Epidemiologia, Escola de Medicina, Universidade Federal de Ouro Preto, Ouro Preto, Minas Gerais, Brazil.
Intestinal parasitic infections are a common health problem among Amerindian populations and schistosomiasis represents one of the most prevalent diseases in Maxakali people. The Kato-Katz is the diagnostic method recommended by WHO for epidemiological studies; however, one of the technique's limitations is the failure to detect parasites in individuals with low parasite load. The aim of this study was to establish the prevalence of Schistosoma mansoni in indigenous Maxakali villages, evaluating the TF-Test® performance for diagnosis compared to the Kato-Katz technique. Read More
Syst Parasitol 2018 09 2;95(7):645-654. Epub 2018 Jul 2.
School of Biological Sciences, The University of Queensland, St Lucia, QLD, 4072, Australia.
Two new species of Bacciger Nicoll, 1914 (Faustulidae) are described infecting clupeids collected from the waters off Queensland, Australia; Bacciger minor n. sp. is described from Herklotsichthys castelnaui (Ogilby) in Moreton Bay, southern Queensland and Bacciger major n. Read More
Wiad Lek 2018;71(3 pt 2):674-677
Danylo Halytsky Lviv National Medical University, Lviv, Ukraine, Lviv Municipal Centre For Family Planning And Human Reproduction, Lviv, Ukraine.
Objective: The aim: The purpose of this study is to analyze the frequency and structure of parasitic lesion in women with reproductive health disorders.
Patients And Methods: Materials and methods: The immune-enzyme method tested immunoglobulins IgG to ascaris, lamblia, toxocara. Determination of the presence of pinworm eggs (sticky tape and perianal scrape method) and ascarid (methods of K. Read More
Infect Genet Evol 2018 Sep 18;63:95-103. Epub 2018 May 18.
Departament of Parasitology, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil. Electronic address:
Species of the genus Posthodiplostomum are intestinal parasites of piscivorous birds with worldwide distribution. Recent molecular surveys have focused on developmental stages from vertebrate hosts, with few sequences from larvae found in molluscs. Moreover, most published molecular data are from collections in North America, Europe and Asia, and there are no data for South American species. Read More
Parasitol Int 2018 Apr 27;67(5):565-574. Epub 2018 Apr 27.
Mie University Graduate School, Faculty of Bioresources, Tsu, Mie 514-8507, Japan.
In the 1970's and 1980's, an unknown species of the genus Brachylaima (Trematoda: Brachylaimidae) had been recorded from the intestines of Rattus norvegicus and Apodemus speciosus in Hokkaido, Japan. The rodent fluke was characteristic in extending a bilateral vitellarium till the level of posterior margin of anterior testis and in keeping almost the same-sized spherical ovary and testes. In this study, the rodent fluke was rediscovered from A. Read More
BMC Complement Altern Med 2018 Apr 27;18(1):135. Epub 2018 Apr 27.
Department of Biochemistry, College of Science, King Saud University, Riyadh, Kingdom of Saudi Arabia.
Background: Schistosomiasis is an acute and chronic zoonotic parasitic disease caused by trematode worms. The host inflammatory response to schistosome eggs leads to perioval granulomata formation, mainly in the liver and intestine. This study investigated the potential antischistosomal and anti-inflammatory activity of both garlic extract and allicin on liver fibrotic markers in BALB/c mice with schistosomiasis (S. Read More
Parasitol Res 2018 Jun 25;117(6):1877-1890. Epub 2018 Apr 25.
Frank C. Bellrose Waterfowl Research Center, Forbes Biological Station, Illinois Natural History Survey, Prairie Research Institute, University of Illinois Urbana-Champaign, 20003 CR 1770E, Havana, IL, 62644, USA.
Thousands of lesser scaup (Aythya affinis) die during spring and fall migrations through the upper Midwest, USA, from infections with Cyathocotyle bushiensis and Sphaeridiotrema spp. (Class: Trematoda) after ingesting infected intermediate hosts, such as non-native faucet snails (Bithynia tentaculata). The lesser scaup is a species of conservation concern and is highly susceptible to these infections. Read More
Exp Parasitol 2018 Jun 18;189:61-65. Epub 2018 Apr 18.
National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido, Japan. Electronic address:
Schistosoma japonicum, causing zoonotic intestinal schistosomiasis, is found in China, the Philippines and parts of Indonesia. Severe disease manifestations are basically due to the deposition of eggs in some vital organs such as the liver, spleen and brain. Traditionally, histopathological microscopic examination of the egg burden was used to evaluate the intensity of infection in the affected organs. Read More
Parasitol Res 2018 Jun 10;117(6):1765-1772. Epub 2018 Apr 10.
Institute of Biological Problems of the North, Far East Branch of the RAS, Russian Academy of Sciences, 18 Portovaya Street, Magadan, 685000, Russia.
Phylogenetic relationship reconstruction and taxonomical analysis of trematodes of the genus Bunodera was carried out using 28S rDNA partial sequences along with a description and molecular characterisation of a new species, B. vytautasi sp. nov. Read More
PLoS One 2018 6;13(4):e0194161. Epub 2018 Apr 6.
Department of Parasitology, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Centrocestus formosanus is a foodborne intestinal trematode that is native to Asia and has been introduced into the Americas and Europe. Although there are several studies of C. formosanus in definitive vertebrate hosts (birds and mammals, including humans), and in intermediate vertebrate hosts (fish and amphibians), there is little published information regarding interaction with its transmitting mollusc. Read More
Korean J Parasitol 2018 Feb 28;56(1):75-79. Epub 2018 Feb 28.
Department of Parasitology, Korea University College of Medicine, Seoul 02841, Korea.
Adult specimens of (Garrison, 1908) Odhner, 1911 (Trematoda: Echinostomatidae) were recovered from 2 riparian people who resided along the Mekong River in Savannakhet Province, Lao PDR. In fecal examinations done by the Kato-Katz technique, they revealed echinostome eggs together with eggs of (and minute intestinal fluke eggs) and hookworms. To recover the adult flukes, they were treated with praziquantel 30-40 mg/kg in a single dose and purged with magnesium salts. Read More
PLoS Negl Trop Dis 2018 03 8;12(3):e0006274. Epub 2018 Mar 8.
Laboratório de Biologia Parasitária, School of Sciences, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, Brazil.
Control initiatives have successfully reduced the prevalence and intensity of schistosomiasis transmission in several localities around the world. However, individuals that release low numbers of eggs in their feces may not be detected by classical methods that are limited by low sensitivity. Given that accurate estimates of prevalence are key to implementing planning control actions for the elimination of schistosomiasis, new diagnostic tools are needed to effectively monitor infections and confirm transmission interruption. Read More
PLoS Negl Trop Dis 2018 02 22;12(2):e0006232. Epub 2018 Feb 22.
Departamento de Parasitologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brasil.
Background: In some tropical countries, such as Brazil, schistosomiasis control programs have led to a significant reduction in the prevalence and parasite burden of endemic populations. In this setting, the Kato-Katz technique, as the standard diagnostic method for the diagnosis of Schistosoma mansoni infections, which involves the analysis of two slides from one fecal sample, loses its sensitivity. As a result, a significant number of infected individuals are not detected. Read More
Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 2017 Jul;29(5):640-643
Center for Disease Control and Prevention of Shixing County, Guangdong Province, Shixing 512500, China.
Objective: To analyze the results of 3 investigations (2002-2004, 2008-2009, and 2016) of major parasitic diseases in Shixing County, so as to provide the evidence for formulating further control strategies.
Methods: With the stratified cluster sampling method, 5 administrative villages were investigated. A total of 200 residents aged above 3 years were sampled in each village to investigate the eggs of soil-transmitted nematodes with Kato-Katz technique, and the swab method was applied for detecting the eggs of Enterobius vermicularis in children aged 3-9 years. Read More
Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 2017 Mar;29(2):150-154
Beijing Tropical Medicine Research Institute, Beijing Key Laboratory for Prevention and Treatment of Tropical Diseases, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.
Objective: To analyze the clinical features of 6 patients with imported schistosomiasis mansoni, including the epidemic history, clinical manifestations, laboratory tests and therapeutic effect, so as to provide references for improving the levels of diagnosis and treatment of physicians.
Methods: The clinical data of 6 patients with imported schistosomiasis mansoni from January 2009 to July 2016 were collected and analyzed.
Results: All the 6 imported patients with schistosomiasis mansoni had a clear history of cercarial infested water exposure. Read More
Parasitol Res 2018 Apr 12;117(4):1079-1086. Epub 2018 Feb 12.
I. I. Schmalhausen Institute of Zoology NAS of Ukraine, B. Khmelnitsky Street, 15, Kyiv, 01030, Ukraine.
A parasitological survey of 651 northern fur seals Callorhinus ursinus L. from five subpopulations was conducted on St. Paul Island, Alaska, during July-August 2012-2014. Read More
Parasitol Res 2018 Apr 12;117(4):947-957. Epub 2018 Feb 12.
Departamento de Parasitología, Facultad de Farmacia, Universidad de Valencia, Avda. Vicent Andrés Estellés s/n, Burjassot, 46100, Valencia, Spain.
Echinostoma caproni (Trematoda: Echinostomatidae) is an intestinal trematode, broadly employed to study the host-dependent mechanisms that govern the evolution of intestinal helminth infections. Resistance against E. caproni homologous secondary infections has been reported in mice and appears to be related to the generation of a local Th2 response, whereas Th1 responses promote the development of chronic primary infections. Read More
Parasitol Res 2018 Apr 2;117(4):1043-1049. Epub 2018 Feb 2.
Formerly School of Environmental Studies, Queen's University, Kingston, Ontario, Canada.
White grub flukes, Posthodiplostomum minimum centrarchi (Trematoda), and hookworms Pomphorhynchus bulbocolli (Acanthocephala) are common internal parasites for many North American freshwater fishes. P. minimum are found as cysts in internal organ tissues, while P. Read More
Syst Parasitol 2018 03 25;95(2-3):213-222. Epub 2018 Jan 25.
Ecology Degree Programme, University of Otago, P.O. Box 56, Dunedin, 9054, New Zealand.
As a part of a comprehensive survey of macroparasites of commercially exploited fish species off the coast of Otago, New Zealand, the parasite fauna of the New Zealand sole Peltorhamphus novaezeelandiae Günther was recently studied. Steringotrema robertpoulini n. sp. Read More
Syst Parasitol 2018 03 22;95(2-3):133-145. Epub 2018 Jan 22.
Aquaculture & Aquatic Sciences and Aquatic Parasitology Laboratory, School of Fisheries, Auburn University, 203 Swingle Hall, Auburn, AL, 36849, USA.
Platt sinuosus Roberts & Bullard n. g., n. Read More
Parasit Vectors 2017 12 29;10(1):626. Epub 2017 Dec 29.
Department of Medical Zoology, Kyung Hee University School of Medicine, Seoul, South Korea.
Background: Human clonorchiasis, caused by the infection of Clonorchis sinensis, is one of the major health problems in Southeast Asia. However, vaccine efficacy against C. sinensis infection remains largely unknown. Read More
Parasitol Int 2018 Jun 19;67(3):321-340. Epub 2017 Dec 19.
School of Biological Sciences, The University of Queensland, Brisbane, Queensland 4072, Australia.
Seven species of Psettarium (Digenea: Aporocotylidae), including four new species, are reported from tetraodontiform fishes from off coastal east Queensland. Psettarium pandora n. sp. Read More
PLoS Negl Trop Dis 2017 12 8;11(12):e0006061. Epub 2017 Dec 8.
Schistosomiasis Control Initiative, Department of Infectious Disease Epidemiology, Imperial College London, London, United Kingdom.
Background: In Mozambique, schistosomiasis is highly endemic across the whole country. The Schistosomiasis Consortium for Operational Research and Evaluation (SCORE) coordinates a five-year study that has been implemented in various African countries, including Mozambique. The overall goal of SCORE was to better understand how to best apply preventive chemotherapy with praziquantel (PZQ) for schistosomiasis control by evaluating the impact of alternative treatment approaches. Read More
Int J Infect Dis 2018 Jan 8;66:26-32. Epub 2017 Nov 8.
Molecular Parasitology Laboratory, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Objective: The aim of this study was to develop a vaccine against schistosomiasis, which is a major challenge due to the complex lifecycle of the causative schistosome parasite.
Methods: SmKI-1 is a 16-kDa Kunitz-type protease inhibitor present in the excretory-secretory products and tegument of adult worms and eggs of Schistosoma mansoni. Two independent vaccine trials were performed in mice to determine the efficacy of rSmKI-1 in developing protective immunity. Read More
Korean J Parasitol 2017 Oct 31;55(5):579-582. Epub 2017 Oct 31.
Division of Vectors and Parasitic Diseases, Centers for Disease Control and Prevention, Osong 28159, Korea.
To investigate the prevalence of intestinal parasite infections in Yanbian Prefecture, Jilin Province, China, epidemiological surveys were conducted on a collaboration basis between the Korean Centers for Disease Control and Prevention and the Yanbian Center for Disease Control and Prevention. A total of 8,396 (males 3,737 and females 4,659) stool samples were collected from 8 localities and examined with the formalin-ether sedimentation technique, and additionally examined with the cellotape anal swab to detect Enterobius vermicularis eggs. The overall rate of intestinal parasites was 1. Read More
Korean J Parasitol 2017 Oct 31;55(5):575-578. Epub 2017 Oct 31.
Department of Parasitology, Medical Research Institute and Parasite Resource Bank, Chungbuk National University School of Medicine, Cheongju 28644, Korea.
Aspidogastrid trematodes (Subclass Aspidogastrea) are a relatively small group with a characteristic adhesive disc and parasitize in a variety of cold-blooded hosts. Until now, only 2 species in the genus Cotylaspis, i.e. Read More
PLoS Negl Trop Dis 2017 Nov 2;11(11):e0006030. Epub 2017 Nov 2.
Department of Microbiology, Faculty of Science, Mahidol University, Bangkok, Thailand.
Background: Opisthorchis viverrini infection is a major public health problem in northern and northeastern Thailand. The chronic infection of O. viverrini is related to cholangiocarcinoma which causes high mortality in endemic areas. Read More
Exp Parasitol 2017 Dec 23;183:56-63. Epub 2017 Oct 23.
Biology Institute, Animal Biology Department, Campinas State University (UNICAMP), SP, Brazil. Electronic address:
Human schistosomiasis is an important neglected tropical disease caused by blood flukes of the genus Schistosoma and is responsible for more than 280,000 deaths annually. Treatment for this disease relies currently on a single drug, praziquantel (PZQ). Concerns regarding PZQ resistance and insensitivity of juvenile schistosomes have increased the interest in resorting to medicinal plants for alternative drug therapies. Read More
J Fish Dis 2018 Feb 24;41(2):299-307. Epub 2017 Oct 24.
Department of Life Sciences & Biotechnology, University of Ferrara, Ferrara, Italy.
The histopathology and ultrastructure of the intestine of mullets, Liza ramada and Liza saliens, from Comacchio lagoons (northern Italy) naturally infected with myxozoans and helminths were investigated and described. Sixty-two (80.5%) of 77 mullets harboured one or more of the following parasites species: Myxobolus mugchelo (Myxozoa), Neoechinorhynchus agilis (Acanthocephala), Haplosplanchnus pachysomus and Dicrogaster contractus (Digenea). Read More
Parasitol Res 2017 Nov 12;116(11):3175-3188. Epub 2017 Oct 12.
Center for Tropical Medicine and Infectious Diseases, School of Medicine, Texas Tech University Health Sciences Center, Lubbock, TX, USA.
Schistosomiasis remains a major global health problem. Despite large-scale schistosomiasis control efforts, clear limitations such as possible emergence of drug resistance and reinfection rates highlight the need for an effective schistosomiasis vaccine. Schistosoma mansoni large subunit of calpain (Sm-p80)-based vaccine formulations have shown remarkable efficacy in protecting against S. Read More
Rev Med Suisse 2017 Oct;13(578):1741-1744
Clinique de médecine, HFR Fribourg - Hôpital cantonal, 1708 Fribourg.
Food-borne trematodiases (flukes) are transmitted through the consumption of contaminated undercooked aquatic food. Infections are most prevalent in Southeast Asia and Latin America, but might occur anywhere due to food trade, international travel, human migration. Clinical manifestations are hepatobiliary, intestinal, and pleuropulmonary. Read More
PLoS Negl Trop Dis 2017 Oct 4;11(10):e0005953. Epub 2017 Oct 4.
Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland.
The Kato-Katz technique is the most widely used diagnostic method in epidemiologic surveys and drug efficacy trials pertaining to intestinal schistosomiasis and soil-transmitted helminthiasis. However, the sensitivity of the technique is low, particularly for the detection of light-intensity helminth infections. Examination of multiple stool samples reduces the diagnostic error; yet, most studies rely on a single Kato-Katz thick smear, thus underestimating infection prevalence. Read More
J Helminthol 2018 Sep 4;92(5):563-571. Epub 2017 Oct 4.
División Zoología Invertebrados,Museo de La Plata,Facultad de Ciencias Naturales y Museo,Universidad Nacional de La Plata (UNLP),Paseo del Bosque S/N°, 1900 La Plata,Buenos Aires Province,Argentina.
In March 2011, a predator killed 33 hooded grebes, Podiceps gallardoi Rumboll (Podicipedidae), a critically endangered species, in a nesting colony at El Cervecero Lake, Santa Cruz Province, Argentina. The viscera of ten birds were examined for helminths. Two new species of Trematoda were recovered from the intestines. Read More
PLoS One 2017 3;12(10):e0185870. Epub 2017 Oct 3.
Section of Parasitology, Department of Zoology, Aligarh Muslim University, Aligarh, India.
The digenetic trematode Fasciola gigantica is a parasite of great agricultural and economic importance. Along with Fasciola hepatica, F. gigantica incurs huge economic losses to the agricultural sector. Read More
PLoS Negl Trop Dis 2017 Oct 2;11(10):e0005982. Epub 2017 Oct 2.
Social Aspects of Health Programme, Medical Research Council/ Uganda Virus Research Institute (MRC/ UVRI) Uganda Research Unit, Uganda Virus Research Institute, Entebbe, Uganda.
Background: Praziquantel-based mass treatment is the main approach to controlling schistosomiasis mansoni in endemic areas. Interventions such as provision and use of safe water, minimising contact with infested water, disposal of stool in latrines and snail control provide key avenues to break the transmission cycle and can sustain the benefits of mass treatment in the long term. Efforts are also being made to develop a schistosomiasis vaccine which, if effective, might reduce the incidence of re-infection after treatment. Read More
Biomed Pharmacother 2017 Nov 19;95:1346-1358. Epub 2017 Sep 19.
Department of Public Health and Community Medicine, Faculty of Medicine, Mansoura University, Mansoura, Egypt. Electronic address:
Background And Objective: Tyrphostin "AG1024" is an insulin growth factor-1 receptor (IGF-1R) inhibitor that displayed an effect on the viability of larval and mature schistosomes in vitro. We sought to investigate the possible in vivo role of AG1024 as a potential new anti-Schistosoma drug against immature and adult stages of Schistosoma mansoni and its effect on the degree of hepatic fibrosis and insulin pathway.
Methods: The study included a control non-infected group and 5 groups of S. Read More
PLoS Negl Trop Dis 2017 Sep 21;11(9):e0005942. Epub 2017 Sep 21.
Merck Global Health Institute, Ares Trading S.A., a subsidiary of Merck KGaA (Darmstadt, Germany), Coinsins, Switzerland.
After more than 40 years of use, Praziquantel (PZQ) still remains the drug of choice for the treatment of intestinal and urogenital schistosomiasis. Its anti-parasitic activity resides primarily in the (R)-enantiomer. Hitherto neither the molecular target nor the pharmacokinetic-pharmacodynamic relationship have been fully elucidated. Read More
Int J Public Health 2018 Mar 19;63(2):233-239. Epub 2017 Sep 19.
Swiss Tropical and Public Health Institute, CH-4002, Basel, Switzerland.
Objectives: Our study aimed at determining the prevalence of selected infectious diseases among recently arrived Eritrean refugees in Switzerland.
Methods: In this cross-sectional study, asymptomatic Eritrean migrants aged ≥16 years who arrived <24 months ago were recruited at refugee centres in Switzerland. Infectious disease screening included serology for HIV, hepatitis B and C, syphilis and schistosomiasis, polymerase chain reaction (PCR) for malaria, stool microscopy for helminths and intestinal protozoa and circulating cathodic antigen (CCA) testing in urine for schistosomiasis. Read More
Int J Pharm 2017 Nov 18;533(1):26-33. Epub 2017 Sep 18.
Univ. Lille, Inserm, CHU Lille, U1008 - Controlled Drug Delivery Systems and Biomaterials, F-59000 Lille, France. Electronic address:
The aim of this work was to prepare and characterize (in vitro and in vivo) PLGA-based microparticles loaded with an enzymatic protein derived from the helminth parasite Schistosoma haematobium: glutathione S-transferase P28GST (P28GST). This protein is not only a promising candidate vaccine against schistosomiasis, it also exhibits interesting immunomodulating effects, which can be helpful for the regulation of inflammatory diseases. Helminths express a regulatory role on intestinal inflammation, and immunization by P28GST has recently been shown to be as efficient as infection to reduce inflammation in a murine colitis model. Read More
Proc Natl Acad Sci U S A 2017 10 15;114(40):E8430-E8439. Epub 2017 Sep 15.
Institute of Infectious Diseases and Molecular Medicine (IDM), Division of Immunology and South African Medical Research Council (SAMRC), Immunology of Infectious Diseases, Faculty of Health Sciences, University of Cape Town, Cape Town 7925, South Africa;
Interleukin-4 (IL-4)-induced T helper (Th) 2 cells promote susceptibility to the protozoan parasite , while conferring immunity to the intestinal trematode Here, we report that abrogation of IL-4 receptor alpha (IL-4Rα) signaling on B cells in BALB/c mice (IL-4Rα) transformed nonhealer BALB/c to a healer phenotype with an early type 1 and dramatically reduced type 2 immune response and an absence of ulceration and necrosis during cutaneous leishmaniasis. From adoptive reconstitution and mixed bone-marrow chimera studies in B cell-deficient (µMT) mice, we reveal a central role for B cell-derived IL-4 and IL-4Rα in the optimal induction of the susceptible type 2 phenotype to infection. We further demonstrate that the absence of IL-4Rα signaling on B cells exacerbated -induced mortality and pathology in BALB/c mice, due to a diminished type 2 immune response. Read More
Theranostics 2017 15;7(14):3446-3460. Epub 2017 Aug 15.
Department of parasitology of Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong 510080, China.
Epidemiologic studies and animal model experiments have shown that parasites have significant modulatory effects on autoimmune disorders, including inflammatory bowel disease (IBD). Recombinant Sj16 (rSj16), a 16-kDa secreted protein of () produced by (), has been shown to have immunoregulatory effects and . In this study, we aimed to determine the effects of rSj16 on dextran sulfate sodium (DSS)-induced colitis. Read More
Int Health 2017 09;9(5):288-293
Medical Microbiology/Parasitology Unit, Department of Medical Laboratory Science, University of Calabar, Cross River State, Nigeria.
Background: Praziquantel (PZQ) is the current drug of choice for the treatment of urinary schistosomiasis in endemic areas. It is very efficacious, although the potential for the development of resistance has been reported in some endemic areas among human subjects and in animal studies. Its' limitation include high cost and administration of multiple numbers of tablets. Read More
World J Gastroenterol 2017 Aug;23(31):5700-5712
Department of Gastroenterology, Key Laboratory of Hubei Province for Digestive System Disease, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province, China.
Aim: To elucidate the impact of (.) infection on inflammatory bowel disease by studying the effects of exposure to cercariae on dextran sodium sulfate (DSS)-induced colitis.
Methods: Infection was percutaneously established with 20 ± 2 cercariae of , and colitis was induced by administration of 3% DSS at 4 wk post infection. Read More
Korean J Parasitol 2017 Aug 31;55(4):451-455. Epub 2017 Aug 31.
Institute of Research and Development, Scorpiogen Co., Anseong 17579, Korea.
Echinostoma cinetorchis is an oriental intestinal fluke causing significant pathological damage to the small intestine. The aim of this study was to determine a full-length cDNA sequence of E. cinetorchis endoribonuclease (RNase H; EcRNH) and to elucidate its molecular biological characters. Read More
Proc Natl Acad Sci U S A 2017 09 5;114(38):10214-10219. Epub 2017 Sep 5.
Center for Parasitic Organisms, State Key Laboratory of Biocontrol, Key Laboratory of Gene Engineering of the Ministry of Education, School of Life Sciences, Sun Yat-Sen University, Guangzhou 510275, People's Republic of China;
Human schistosomiasis, caused by species, is a major public health problem affecting more than 700 million people in 78 countries, with over 40 mammalian host reservoir species complicating the transmission ecosystem. The primary cause of morbidity is considered to be granulomas induced by fertilized eggs of schistosomes in the liver and intestines. Some host species, like rats (), are naturally intolerant to infection, and do not produce granulomas or pose a threat to transmission, while others, like mice and hamsters, are highly susceptible. Read More