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Int J Gynecol Cancer 2019 Feb 4;29(2):444-445. Epub 2019 Feb 4.

UOC di Ginecologia Oncologica, Department of Women's and Children's Health, Fondazione Policlinico Universitario A Gemelli IRCCS, Roma, Italia.

This video article demonstrates an inguino-abdominal combined approach for laterally extended pelvic resection, a major surgical procedure for locally advanced primary or recurrent gynecological cancer infiltrating the pelvic sidewall, for which palliative therapy is the only alternative.1 After local institutional review board approval (protocol No CICOG 02/03/62), we made a step by step surgical video of an inguino-abdominal combined approach for laterally extended pelvic resection , defined as an en bloc resection of a pelvic tumor with pelvic sidewall structures, including the iliopsoas and/or obturator internus muscles.2 3 The patient, a 48-year-old woman, diagnosed with single pelvic platinum resistant recurrence after five lines of chemotherapy for serous ovarian cancer G3, International Federation of Gynecology and Obstetrics (FIGO) stage IIIC, BRCA wild type. Read More

BMJ Case Rep 2019 Jan 29;12(1). Epub 2019 Jan 29.

Department of General Surgery, Ministry of Health, Dammam, Eastern Province, Saudi Arabia.

Basidiobolomycosis is a rare fungal infection that may affect the gastrointestinal tract. It is caused by and less than 80 cases have been reported in the literature. The incidence seems to be higher in the Middle East and in particular Saudi Arabia where most cases are diagnosed in the south-western region. Read More

N Engl J Med 2019 Jan;380(5):473-485

From the Department of Medicine, Brigham and Women's Hospital (H.M.S.), the Departments of Medicine (F.J.S., K.L.A.), Radiology (T.T.P.), Surgery (M.F.C., M.G.R.), and Orthopedic Surgery (S.D.M.), Massachusetts General Hospital, and the Departments of Medicine (H.M.S., F.J.S., K.L.A.), Radiology (T.T.P.), Surgery (M.F.C., M.G.R.), and Orthopedic Surgery (S.D.M.), Harvard Medical School - all in Boston.

Inflamm Bowel Dis 2019 Jan 18. Epub 2019 Jan 18.

Division ofPediatric Surgery, Mayo Clinic, Rochester Minnesota, USA.

Background: Restorative proctocolectomy and ileal pouch anal anastomosis (IPAA) has become the procedures of choice for restoration of intestinal continuity in ulcerative colitis or familial adenomatous polyposis. This systematic review aims to assess short-term postoperative and long-term functional outcomes in pediatric patients undergoing IPAA.

Methods: A literature search was performed for all publications of pediatric IPAA in which short- and long-term outcomes were reported. Read More

Ann Plast Surg 2019 Feb;82(2):213-217

From the Department of Plastic & Reconstructive Surgery and Maxillofacial Surgery, Kurume University Hospital, Fukuoka, Japan.

Abdominal surgical wound dehiscence with bowel exposure and infection carries a risk of intestinal fistula, making it extremely difficult to treat. The objective at this time is to heal such wounds safely and absolutely with using intrawound continuous negative pressure and irrigation treatment and artificial dermis. The subjects were 18 patients with abdominal wall dehiscence wounds with bowel exposure. Read More

Zhonghua Wei Chang Wai Ke Za Zhi 2018 Dec;21(12):1337-1346

Surgeon Committee of Gastrointestinal Fistula of Chinese College of Surgeons, Email:

Crohn disease (CD) is a chronic inflammatory disease involving the entire digestive tract and non-perianal fistula is the most serious surgical complication of CD. The goal of treatment is to cure intestinal fistula and intra-abdominal infection, restore the continuity of digestive tract, reduce postoperative recurrence, and improve the quality of life. Evaluation of nutritional status, especially during perioperative period, is important and nutrition support for malnutritional CD patients is necessary. Read More

Klin Onkol 2018 ;31(5):376-379

Introduction: Benign cystic tumors represent only 2% of all pancreatic tumors (pancreatic cancer - PC). In contrast to malignant cystic tumors, these tumors occur typically in young women. A solid pseudopapillary tumor is a relatively rare affliction representing less than 4% of cystic PC. Read More

Zhonghua Wei Chang Wai Ke Za Zhi 2018 Nov;21(11):1212-1217

Tongji Hospital Cancer Center, Tongji Medical College Affiliated, Huazhong University of Science and Technology,Wuhan 430030, China. Email:

Malignant acute abdomen is a emergency with abrupt onset, rapid progress and often a complex etiology, presenting difficulties for treatment and high mortality. Therefore, multidisciplinary team (MDT) treatment modality is required. Compared with single-discipline diagnosis and treatment modality, diagnosis made from MDT discussion is more accurate, where specialists can improve efficiency and quality of the treatment through better communication. Read More

J Cardiovasc Surg (Torino) 2018 Dec;59(6):844-845

Department of Vascular Surgery, Imelda Hospital, Bonheiden, Belgium -

Tech Coloproctol 2018 10 21;22(10):805-807. Epub 2018 Nov 21.

Department of Colorectal Surgery, Prince of Wales Hospital, Sydney, Australia.

Medicine (Baltimore) 2018 Nov;97(47):e13328

Department of Gastroenterology, Ji'nan Central Hospital Affiliated to Shandong University, Jinan, China.

Rationale: Radiation enteritis (RE) is one of the serious complications caused by the radiotherapy and it can occur in any segment of the intestine, including small intestine, colon, and rectum. It can cause a number of serious problems of the intestine, such as chronic ulcers, bleeding, intestinal stenosis, intestinal fistula, and perforation. At present, there is no standard treatment guideline for the RE. Read More

World J Surg Oncol 2018 Nov 10;16(1):220. Epub 2018 Nov 10.

Department of Colorectal Surgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital and Institute, No 44 Xiaoheyan Road, Dadong District, Shenyang, 110042, Liaoning Province, People's Republic of China.

Objectives: To explore whether single-incision laparoscopic surgery (SILS) has the better short-term clinical and pathological outcomes than conventional multiport laparoscopic surgery (CLS) for sigmoid colon and rectal cancer.

Methods: A literature investigation of MEDLINE, PubMed, Ovid, Embase, Cochrane Library, Web of Science, Chinese National Knowledge Infrastructure (CNKI), Chinese Biological Medicine (CBM), and Wanfang databases for relevant researches was performed. Fixed effects and random effects models were used to calculate the corresponding outcomes. Read More

Medicine (Baltimore) 2018 Nov;97(45):e12822

Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, P. R. of China.

Rationale: Vertebral defect, anal atresia, cardiac defect, tracheoesophageal fistula/esophageal atresia, renal defect, and limb defect (VACTERL) association and Müllerian duct anomalies are rare conditions. We present a rare condition with the co-occurrence of the VACTERL association and Müllerian duct hypoplasia to characterize patients' clinical presentations, outcomes, and treatment.

Patient Concerns: An 11-year-old girl presented to our hospital with severe lower abdominal pain, lower vaginal atresia with enlargement of the upper vagina and a bicornuate uterus with a Y-shaped uterine cavity filled with hematometra on pelvic magnetic resonance imaging. Read More

World J Stem Cells 2018 Oct;10(10):134-137

Bone Marrow Transplant Department, Associação Portuguesa de Beneficência, São José do Rio Preto, SP 15090 470, Brazil.

Crohn's disease (CD) is an inflammatory bowel disease that can affect any site of the digestive system. It occurs due to an immunological imbalance and is responsible for intestinal mucosal lesions and complications such as fistulas and stenoses. Treatment aims to stabilize the disease, reducing the symptoms and healing intestinal lesions. Read More

Ann R Coll Surg Engl 2019 Feb 24;101(2):e59-e61. Epub 2018 Oct 24.

Department of General Surgery, Queen Elizabeth University Hospital , Glasgow , UK.

An 84-year-old woman presented with acute worsening of diarrhoea for a few weeks, with a background of chronic diarrhoea over the past 12 months accompanied by weight loss. Computed tomography during this admission revealed air in the biliary tree and resolution of gallstones in keeping with a cholecystocolonic fistula. Owing to her comorbidities, surgical management was deemed not to be the best option. Read More

Int J Surg 2018 Dec 19;60:9-14. Epub 2018 Oct 19.

Department of Coloproctology, Yang Hospital, Seoul, Republic of Korea.

Background: Ligation of the intersphincteric fistula tract (LIFT) is a sphincter-preserving operation for anal fistulas. Although it has advantages in preserving continence after surgery, it is difficult to perform owing to the narrow field of view. We performed a modified surgical procedure based on the LIFT to overcome these drawbacks. Read More

Trop Med Int Health 2019 Jan 8;24(1):81-90. Epub 2018 Nov 8.

Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, China.

Objectives: Intestinal tuberculosis (ITB) remains prevalent and a big health hazard in China. The aim of this study was to retrospectively analyse its clinico-pathological features.

Methods: Retrospective study of 85 consecutive ITB patients in two tertiary hospitals in East China. Read More

Int Urogynecol J 2018 Oct 16. Epub 2018 Oct 16.

Institute for Clinical Evaluative Sciences, Toronto, ON, Canada.

Introduction And Hypothesis: Vaginal apical suspension is essential for the surgical treatment of pelvic organ prolapse (POP). We aim to evaluate whether the method of apical repair is associated with different re-operation rates for POP recurrence or surgical complications.

Methods: Population-based, retrospective cohort study of all Ontario women receiving primary apical POP repairs from 2003 to 2015. Read More

BMJ Case Rep 2018 Oct 12;2018. Epub 2018 Oct 12.

General Surgery, Sree Balaji Medical College and Hospital, Chennai, Tamil Nadu, India.

Medicine (Baltimore) 2018 Sep;97(39):e12411

Department of Pediatrics.

Rationale: The clinical manifestations of VACTERL association include vertebral anomalies, anal atresia, congenital heart diseases, tracheoesophageal fistula, renal dysplasia, and limb abnormalities. The association of intrahepatic anomalies and VACTERL syndrome is a rare coincidence. VACTER syndrome and intrahepatic bile drainage anomalies might be genetically related. Read More

Onco Targets Ther 2018 19;11:5527-5533. Epub 2018 Sep 19.

Department of Gynecology, Obstetrics and Gynecology Hospital, Fudan University, Shanghai, People's Republic of China,

Purpose: Although definitive chemoradiotherapy is considered as a standard of care for FIGO stage IIB cervical cancer in many countries, the role of surgery remains controversial. We aimed to evaluate the feasibility and outcomes of patients with FIGO stage IIB cervical cancer who received radical surgery in China.

Patients And Methods: A total of 74 women with FIGO stage IIB cervical cancer were treated with radical hysterectomy, with or without adjuvant radio/chemoradiotherapy, at the Obstetrics and Gynecology Hospital of Fudan University between 2004 and 2015. Read More

Injury 2019 Jan 24;50(1):160-166. Epub 2018 Sep 24.

Virginia Commonwealth University, Richmond, Virginia, USA.

Introduction: No definitive data describing associations between cases of Open Abdomen (OA) and Entero-atmospheric fistulae (EAF) exist. The World Society of Emergency Surgery (WSES) and the Panamerican Trauma Society (PTS) thus analyzed the International Register of Open Abdomen (IROA) to assess this question.

Material And Methods: A prospective analysis of adult patients enrolled in the IROA. Read More

World J Gastroenterol 2018 Sep;24(35):4014-4020

Division of Gastroenterology and Hepatology, University of North Carolina, Charlotte, NC 28204, United States.

Endoscopy plays a fundamental role in the diagnosis, management, and treatment of inflammatory bowel disease (IBD). Colonoscopy, flexible sigmoidoscopy, and esophagogastroduodenoscopy have long been used in the care of patients with IBD. As endoscopic technologies have progressed, tools such as endoscopic ultrasound, capsule endoscopy, and balloon-assisted enteroscopy have expanded the role of endoscopy in IBD. Read More

Turk J Gastroenterol 2018 07;29(4):406-410

Department of General Surgery, Acıbadem Mehmet Ali Aydınlar University School of Medicine, İstanbul, Turkey.

Background/aims: Most of the patients with Crohn's disease (CD) may require at least one surgical procedure over their lifetime. However, these patients tend to have a high incidence of postoperative complications. The aim of this retrospective study was to investigate the predictive parameters of postoperative complications in CD. Read More

Zhejiang Da Xue Xue Bao Yi Xue Ban 2018 May;47(3):255-260

Department of Thoracic and Oncological Surgery, Qilu Children's Hospital of Shandong University, Jinan 250022, China.

Objective: To summarize experience in the treatment of complex congenital intestinal atresia in children, so as to investigate the key points and effect of the operation.

Methods: Medical notes of 49 children with complex intestinal atresia treated between January 2012 and January 2018 were reviewed. The information of age, sex, age at operation, full-term or premature, birth weight, clinical manifestation, auxiliary examination, preliminary diagnosis, treatment process, discharge diagnosis, pathological results and prognosis of patients were analyzed. Read More

Tech Coloproctol 2018 09 15;22(9):657-662. Epub 2018 Sep 15.

Colon and Rectal Surgery Division, Humanitas Clinical and Research Center, Via Alessandro Manzoni, 56, 20089, Rozzano, Milan, Italy.

Background: Laparoscopic sigmoidectomy is the gold standard for elective surgical treatment of diverticulitis. A periumbilical single-port technique reduces the size of the access wound, usually to 3-4 cm. However, in the presence of large phlegmon or fistulae, the risk of conversion is higher and the extraction site might be enlarged. Read More

Anticancer Res 2018 Sep;38(9):5521-5524

Surgical Oncology Unit, Veneto Institute of Oncology IOV-IRCCS, Padua, Italy.

Background: Our aim was to analyze the safety and efficacy of iterative cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (iCRS-HIPEC) in patients with peritoneal recurrence from different tumor types.

Patients And Methods: Data on indications, intraoperative findings and postoperative outcome of all patients treated with iCRS-HIPEC at our Institution were reviewed.

Results: Between 2010-2018, 10 iCRS-HIPEC procedures for peritoneal recurrence in eight patients were performed. Read More

BMJ Case Rep 2018 Sep 4;2018. Epub 2018 Sep 4.

University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA.

Biliary anatomic pathologies are rare disease occurrences that can result from a number of causes, most commonly iatrogenic, infectious and malignant aetiologies. Communications between the biliary and bronchial systems are even rarer and few cases have been documented in the literature. The present study describes a case of a 70-year-old man who underwent a pancreaticoduodenectomy (Whipple Procedure) as a curative procedure for an early stage neuroendocrine tumour. Read More

J Coll Physicians Surg Pak 2018 Sep;28(9):717-718

Department of Surgery, Surgical D Ward, Khyber Teaching Hospital, Peshawar.

Intrauterine contraceptive device (IUCD) is a form of contraception used for long durations and is most common method used worldwide. It is associated with rare but serious complications. Migration of IUCD into the abdominal cavity can cause injuries to adjacent organs leading to intestinal and bladder perforation, omental and mesenteric injuries, strictures and fistula formation. Read More

BMJ Case Rep 2018 Aug 27;2018. Epub 2018 Aug 27.

General Surgery, NYU Langone Medical Center, Brooklyn, New York, USA.

BMJ Case Rep 2018 Aug 27;2018. Epub 2018 Aug 27.

Department of General Surgery, Instituto Nacional de Ciencias Médicas y Nutrición "Salvador Zubirán", Mexico City, Mexico.

Mymensingh Med J 2018 Jul;27(3):513-519

Dr Md Shofiqul Islam, Senior Consultant (Surgery), 250 Bedded General Hospital, Tangail, Bangladesh.

Enterocutaneous fistulae are a major catastrophe to the patients and surgeons and it still has high incidence of morbidity and mortality and their management remains a big challenge. Enterocutaneous fistula presents the surgeon with challenges of metabolic disorders and extensive sepsis. Total management of an intestinal fistula requires skill in nutritional support, stoma therapy, elimination of sepsis, well timed and well carried out surgery. Read More

Hepatobiliary Pancreat Dis Int 2018 Oct 7;17(5):443-449. Epub 2018 Aug 7.

Gastroenterology Surgical Center, Mansoura University, Mansoura 35516, Egypt.

Background: Pancreaticoduodenectomy (PD) is the standard curative treatment for periampullary tumors. The aim of this study is to report the incidence and predictors of long-term survival (≥ 5 years) after PD.

Methods: This study included patients who underwent PD for pathologically proven periampullary adenocarcinomas. Read More

J Vet Med Sci 2018 Nov 17;80(10):1549-1552. Epub 2018 Aug 17.

Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan.

Pneumatosis coli is a rare intestinal disorder in dogs that is characterized by submucosal or subserosal emphysema of the colon. An 8-year-old castrated male Shih Tzu developed anorexia and hematochezia after undergoing surgery for a congenital splenophrenic shunt. Abdominal radiographic examination revealed linear radiolucency throughout the wall of the large intestine. Read More

Pediatr Surg Int 2018 Oct 17;34(10):1111-1115. Epub 2018 Aug 17.

Department of Pediatric Surgery, Saitama Children's Medical Center, Saitama, Japan.

Purpose: Laparoscopic-assisted anorectoplasty (LAARP) is a minimally invasive procedure in which the levator ani muscle is left to potentially improve postoperative fecal continence. This study aimed to retrospectively evaluate postoperative complications and long-term outcomes of fecal continence after LAARP and compare them to those after posterior sagittal anorectoplasty (PSARP).

Methods: Forty-five male patients with high and intermediate anorectal malformation (aged ≥ 4 years) who underwent LAARP or PSARP (LAARP 29, PSARP 16) from 1999 to 2013 were included. Read More

Radiol Clin North Am 2018 Sep 11;56(5):775-789. Epub 2018 Jul 11.

Department of Abdominal Imaging, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA.

In this article, we begin with an introduction of the perianal region anatomy, then review the definition, etiology, epidemiology, and 2 major classification systems of perianal fistulas. The role of MR imaging for assessment of perianal fistulas is mainly discussed. Finally, the medical and surgical treatment principles are reviewed. Read More

Rev Gastroenterol Peru 2018 Apr-Jun;38(2):187-191

Hospital Regional de Tumbes. Tumbes, Perú.

To report the first case of Whipple surgery performed at the Regional Hospital of Tumbes for the treatment of ampullary adenocarcinoma with successful results. A case report of a patient with diagnosis of ampullary adenocarcinoma, in whom was performed the first Whipple surgery at the Regional Hospital of Tumbes, in October, 2014. The patient diagnosed with an obstructive jaundice syndrome due to ampullary adenocarcinoma underwent Whipple surgery. Read More

Medicine (Baltimore) 2018 Aug;97(33):e11890

Department of Cardiovascular Surgery, Second Hospital of Jilin University, Changchun, Jilin, China.

Rationale: Primary aorto-colonic fistula is a rare complication of an abdominal aortic aneurysm. Without surgical treatment, the associated mortality rate is 100%. Even if patients receive timely surgical treatment, they may still die of complications such as infection. Read More

Ann R Coll Surg Engl 2018 Sep 16;100(7):e188-e190. Epub 2018 Aug 16.

Department of General Surgery, Royal Derby Hospital , Derby , UK.

Gallstone ileus is an uncommon cause of bowel obstruction that involves cholecystoenteric fistulation and resultant passage of gallstones into the bowel. In the vast majority of cases, the fistula forms between the gallbladder and duodenum leading to small bowel obstruction. We report a case of cholecystocolic fistulation and subsequent large-bowel obstruction in a 75-year-old woman who presented acutely after taking a bowel preparation for an outpatient colonoscopy during the course of an investigation of anaemia and nonspecific abdominal pain. Read More

Dis Colon Rectum 2018 09;61(9):1102-1107

Surgical Anatomy Unit, Anatomy and Embryology Department, University of Valencia, Valencia, Spain.

Background: Most perianal abscesses have a cryptoglandular origin, following the pathogenesis described by Parks in 1961. Supralevator abscesses have the most uncommon location. Nevertheless, such pathology results in a high morbidity because of their difficult diagnosis and treatment. Read More

World J Clin Cases 2018 Jul;6(7):143-149

Department of Pediatrics, PLA General Hospital, Beijing 100853, China.

Our paper describes the key surgical points of pediatric choledochocystectomy performed completely by Da Vinci robotic system. A choledochocystectomy was safely carried out for a girl at our hospital, and without any complication. Then systematic literature review was done to discuss the methods of intestine surgery and intestinal anastomosis, the use of 3 robotic arm, the surgical safety and advantages comparing open and laparoscopic surgery. Read More

Surg Case Rep 2018 Aug 2;4(1):86. Epub 2018 Aug 2.

Department of Surgery, Saitama Medical Center, Jichi Medical University, 1-847, Amanuma-cho, Omiya, Saitama-shi, Saitama, 330-8503, Japan.

Background: Diversion colitis (DC) is characterized by nonspecific inflammation in the remaining colon or rectum, and loss of the fecal stream plays a major role in the disease's development. Although the majority of patients are asymptomatic, medical and/or surgical treatment is required for those who are symptomatic. There is a particular interest on how to manage patients with acute and severe clinical presentations, but the pathogenesis is not fully understood. Read More

Trials 2018 Jul 31;19(1):409. Epub 2018 Jul 31.

Second Department of Surgery, School of Medicine, Wakayama Medical University, 811-1, Kimiidera, Wakayama, 641-8510, Japan.

Background: Laparoscopic gastrectomy (LG) has several benefits as a treatment of gastric cancer (GC), including reduced pain, early recovery of intestinal function, and shorter hospital stay. LG still has several drawbacks, however, including limited range of movement, amplification of hand tremors, and inconvenient surgical positioning. Around the peripancreatic area, laparoscopic lymph node dissection, therefore, remains challenging; postoperative pancreatic fistula occurs in around 4-7% of patients undergoing LG. Read More

Zhonghua Nei Ke Za Zhi 2018 Aug;57(8):614-616

Department of Gastroenterology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.

This is a complicated and difficult case. The onset symptom of a 62-year-old male was recurrent intestinal obstruction. Ileocecal and ileocolic operation was done twice. Read More

Updates Surg 2018 Dec 27;70(4):449-458. Epub 2018 Jul 27.

Department of Gastroenterology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Duodenal involvement in colonic malignancy is a rare event and poses challenge to surgeons as it may entail major resection in a malnourished patient. Nine patients with malignant colo-duodenal fistula were reviewed retrospectively. Depending on the pattern of duodenal involvement, it was classified as-type I involving lateral duodenal wall less than half circumference; type II involving more than half circumference away from papilla; type III involving more than half circumference close to papilla. Read More

Zhonghua Wei Chang Wai Ke Za Zhi 2018 Jul;21(7):772-778

Department of General Surgery, Jinling Hospital, Nanjing 210002, China.

Objective: To summarize the application of staged ileostomy and closure operation combined with nutritional support therapy in the treatment of chronic radiation intestinal injury(CRII).

Methods: Clinical data of patients with definite radiation history and pathological diagnosis of CRII receiving treatment at Department of General Surgery, Jinling Hospital from January 2012 to December 2016 were retrospectively analyzed. Patients who were diagnosed with tumor recurrence during operation or by postoperative pathology were excluded. Read More

Langenbecks Arch Surg 2018 Aug 24;403(5):581-589. Epub 2018 Jul 24.

Pancreatic Surgery Unit, Humanitas Research Hospital, Humanitas University, Rozzano, Milan, Italy.

Purpose: Ampullary neuroendocrine neoplasms (NENs) account for < 0.3% of gastrointestinal NENs. Surgical options include transduodenal ampullectomy/tumour excision or pancreaticoduodenectomy (PD). Read More

Hernia 2018 Oct 19;22(5):785-792. Epub 2018 Jul 19.

Department of Visceral Surgery and Medicine, University Hospital, Bern, Switzerland.

Background: Open abdomen (OA) may be required in patients with abdominal trauma, sepsis or compartment syndrome. Vacuum-assisted wound closure and mesh-mediated fascial traction (VAWCM) is a widely used approach for temporary abdominal closure to close the abdominal wall. However, this method is associated with a high incidence of re-operations in short term and late sequelae such as incisional hernia. Read More

Tech Coloproctol 2018 07 18;22(7):545-551. Epub 2018 Jul 18.

Department of Colorectal Surgery, Southampton General Hospital, University Hospitals Southampton NHS Trust, Southampton, UK.

Background: Botulinum toxin injected into the internal anal sphincter is used in the treatment of chronic anal fissure but there is no standardised technique for its administration. This randomised single centre trial compares bilateral (either side of fissure) to unilateral injection.

Methods: Participants were randomised to receive bilateral (50 + 50 units) or unilateral (100 units) Dysport injections into the internal anal sphincter in an outpatient setting. Read More

Clin Gastroenterol Hepatol 2018 Aug 23. Epub 2018 Aug 23.

Translational Gastroenterology Research Unit, GIGA-R, University of Liège, Liège, Belgium; Hepato-Gastroenterology and Digestive Oncology Unit, University Hospital, CHU Liège, Belgium.

Background & Aims: Despite significant advances in the treatment of Crohn's disease (CD), most patients still develop stricturing or penetrating complications that require surgical resections. We performed a systematic review of mechanisms and potential treatments for tissue damage lesions in CD patients.

Methods: We searched the PubMed, MBASE, and Cochrane databases from September 2016 through July 2017 for full-length articles on CD, fibrosis, damage lesions, mesenchymal stem cells, and/or treatment. Read More