19,020 results match your criteria Intestinal Fistulas


Definitive chemoradiotherapy plus cetuximab for cancer in the oesophagus or gastro-oesophageal junction.

Cancer Treat Res Commun 2020 Jun 27;24:100187. Epub 2020 Jun 27.

Department of Oncology, Rigshospitalet, Copenhagen, Denmark.

Background: Chemoradiotherapy is standard treatment for localized oesophageal cancer unsuitable for surgery. We aimed to evaluate the efficacy of cetuximab in combination with chemoradiotherapy.

Methods: This non-randomised multicentre phase II trial recruited patients aged 18-75 with WHO performance status 0-2 having squamous cell carcinoma or adenocarcinoma in the oesophagus or gastro-oesophageal junction, T2-4, N0-3, M0 not suitable for surgery. Read More

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http://dx.doi.org/10.1016/j.ctarc.2020.100187DOI Listing

Percutaneous Image-Guided Surgery in Complications After Bariatric Surgery.

J Laparoendosc Adv Surg Tech A 2020 Jun 29. Epub 2020 Jun 29.

DAICIM Foundation, Buenos Aires, Argentina.

Although bariatric surgery is a standardized procedure, it is not without complications. Image-guided surgery allows minimally invasive resolution of complications, making it ideal for bariatric patients. The objective of this work was to analyze the image-guided surgery approach to postoperative complications of bariatric surgery. Read More

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http://dx.doi.org/10.1089/lap.2020.0410DOI Listing

[Intestinal manifestations of Behçet's disease].

Ter Arkh 2019 May 15;91(5):111-119. Epub 2019 May 15.

A.N. Ryzhikh State Scientific Centre of Coloproctology.

Behçet's disease (BD) is a systemic vasculitis of unknown origin, characterized by recurrences of the ulcerative process in the oral cavity and on the genitals, inflammatory damage of the eyes, joints, vessels and other organs. The severity and prognosis of BD determines organ pathology. Intestinal manifestations of BD (intestinal BD) are the least studied. Read More

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http://dx.doi.org/10.26442/00403660.2019.05.000247DOI Listing

[Successful treatment of an aortoduodenal fistula after operation on the abdominal portion of the aorta].

Angiol Sosud Khir 2020 ;26(2):170-174

I.P. Pavlov Ryazan State Medical University of the Ministry of Healthcare of the Russian Federation, Ryazan, Russia; Regional Clinical Hospital, Ryazan, Russia.

Gastrointestinal haemorrhage is a common cause of emergency admission of patients to surgical hospitals. Within the structure of nosological entities, not unreasonably referred to the rarest causes of gastrointestinal bleeding is the formation of an aortointestinal fistula whose early diagnosis is of paramount importance. The clinical picture may be different but it is mostly represented by gastrointestinal haemorrhage. Read More

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http://dx.doi.org/10.33529/ANGIO2020213DOI Listing
January 2020

[Stage-by-stage treatment of vesicovaginal fistula followed by orthotopic plastic surgery of the bladder and vagina with a small intestine].

Khirurgiia (Mosk) 2020 (6):121-124

Petrovsky Russian Research Center of Surgery, Moscow, Russia.

High incidence of iatrogenic lesions of genitourinary system (during gynecological and oncogynecological operations) followed by urogenital fistulae and great percentage of recurrences after reconstructive surgery justify the need to improve surgical reconstruction of genitourinary organs and urine discharge in these patients. Stage-by-stage surgical treatment of a patient with extensive vesicovaginal fistula is reported in the article. A defect was associated with loss of 2/3 of the volume of tissues of adjacent organs. Read More

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http://dx.doi.org/10.17116/hirurgia2020061121DOI Listing
January 2020

[Management of patients with enterocutaneous fistulae].

Khirurgiia (Mosk) 2020 (6):98-103

Vishnevsky National Medical Research Center for Surgery of the Ministry of Health of Russia, Moscow, Russia.

Enterocutaneous fistula (ECF) is the most serious postoperative life-threating complication of various abdominal surgical interventions. Treatment of patients with ECF is associated with life-threatening complications including sepsis and septic shock, intestinal failure and severe water-electrolyte disorders that causes high mortality rates (35-75% according to national authors and 6-33% according to foreign colleagues). This issue is especially relevant in the cases of enteroatmospheric fistulae and high ECF with loss of intestinal contents of more than 500 ml per day. Read More

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http://dx.doi.org/10.17116/hirurgia202006198DOI Listing
January 2020

Laparoscopic stricturoplasty as a treatment of stenosing Crohn's disease - a video vignette.

Colorectal Dis 2020 Jun 21. Epub 2020 Jun 21.

Cirugia Colorrectal, Servicio de Cirugia General y Aparato Digestivo, Hospital Universitario Marques de Valdecilla, Santander, Spain.

Most patients with Crohn's Disease (CD) require emergency or elective surgical interventions sometime during their life. The main indications include failure of medical treatment or the development of complications, such as stenosis, inflammatory mass, perforation and fistulas. The laparoscopic approach is the technique of choice. Read More

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http://dx.doi.org/10.1111/codi.15201DOI Listing

Mannose: Good player and assister in pharmacotherapy.

Biomed Pharmacother 2020 Jun 18;129:110420. Epub 2020 Jun 18.

Marine Medical Research Institute of Guangdong Zhanjiang (GDZJMMRI), Southern Marine Science and Engineering Guangdong Laboratory Zhanjiang, Guangdong Medical University, Zhanjiang, China; Guangdong Key Laboratory for Research and Development of Natural Drugs, School of Pharmaceutical Science, Guangdong Medical University, Zhanjiang, China. Electronic address:

Mannose is a monosaccharide widely distributed in body fluids and tissues, especially in the nerve, skin, testicles, retina, liver and intestines. It is used to synthesize glycoproteins and participate in immune regulation. In recent years, mannose has been applied more and more widely in the biomedical context as people have a deeper understanding of its biological effects. Read More

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http://dx.doi.org/10.1016/j.biopha.2020.110420DOI Listing

When the bowel meets the bladder: Optimal management of colorectal pathology with urological involvement.

World J Gastrointest Surg 2020 May;12(5):208-225

Department of Colorectal Surgery, Galway University Hospital, Galway H91 YR71, Ireland.

Fistulae between the gastrointestinal and urinary systems are rare but becoming increasingly more common in current surgical practice. They are a heterogeneous group of pathological entities that are uncommon complications of both benign and malignant processes. As the incidence of complicated diverticular disease and colorectal malignancy increases, so too does the extent of fistulous connections between the gastrointestinal and urinary systems. Read More

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http://dx.doi.org/10.4240/wjgs.v12.i5.208DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7289647PMC

Salpingo Enteric Fistula: A Case Report.

Int Med Case Rep J 2020 22;13:221-224. Epub 2020 May 22.

Department of General Surgery, Urmia University of Medical Science, Urmia, Iran.

Background: Few cases with fistulous communication between the GI system and female adnexal structure have been reported in the literature, and bilateral contrast spillage has been reported only in one case, and this case is the second one all over the world.

Case Presentation: The case was a 27-year-old woman with a diagnosis of primary infertility. She was booked with hysterosalpingogram (HSG) as part of the routine workup in the infertility clinic. Read More

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http://dx.doi.org/10.2147/IMCRJ.S251652DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7250311PMC

Reply to Letter to Editor-"Catheter-Related Complications of Percutaneous Drainage in Step-up Approach for Management of Pancreatic Necrosis".

J Gastrointest Surg 2020 Jun 15. Epub 2020 Jun 15.

Division of Surgical Gastroenterology, Department of General Surgery, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.

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http://dx.doi.org/10.1007/s11605-020-04685-5DOI Listing

X-linked inhibitor of apoptosis protein deficiency complicated with Crohn's disease-like enterocolitis and Takayasu arteritis: A case report.

Clin Immunol 2020 Jun 12;217:108495. Epub 2020 Jun 12.

Center for Pediatric Inflammatory Bowel Disease, Division of Gastroenterology, National Center for Child Health and Development, Tokyo, Japan.

X-linked inhibitor of apoptosis protein (XIAP) deficiency results in monogenic inflammatory bowel disease. To date, no vasculitis associated with XIAP deficiency has been reported. A 10-year-old boy was diagnosed with Crohn's disease and he responded poorly to conventional treatment for Crohn's disease. Read More

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http://dx.doi.org/10.1016/j.clim.2020.108495DOI Listing

Comparison between surgical techniques in gallstone ileus and outcomes.

Cir Cir 2020 ;88(3):292-296

Departamento de Cirugía General, Centro Médico Instituto de Seguridad Social del Estado de México (ISSEMyM), Ecatepec, Estado de México, México.

Introduction: Gallstone ileus is a rare cause of mechanical bowel obstruction, generally found in elderly patients who often have other significant medical conditions.

Objective: The objective of the study was to determine the prevalence of gallstone ileus and the number of postsurgical complications and outcomes depending on what type of surgical management is performed.

Method: Cohort, retrospective, observational, and comparative study was conducted, which included 31 patients undergoing surgery for gallstone ileus. Read More

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http://dx.doi.org/10.24875/CIRU.19001264DOI Listing
January 2020

Malignant Brenner tumour of the ovary manifesting as distal intestinal obstruction and perforation.

BMJ Case Rep 2020 Jun 11;13(6). Epub 2020 Jun 11.

Department of Surgical Disciplines, All India Institute of Medical Sciences, New Delhi, India

A rare case of malignant Brenner tumour of ovary manifesting with intestinal perforation due to colonic infiltration is elaborated in the present report. Brenner's tumour accounts for 1%-2% of all ovarian neoplasms and malignant Brenner tumour is even rarer and only about 5% of Brenner tumours are malignant. A 62-year-old woman came to surgical emergency with 1-month history of abdominal pain, vomiting and constipation with a palpable mass in right iliac fossa. Read More

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http://dx.doi.org/10.1136/bcr-2020-235394DOI Listing

Levels of TB-IGRA may help to differentiate between intestinal tuberculosis and Crohn's disease in patients with positive results.

Therap Adv Gastroenterol 2020 18;13:1756284820922003. Epub 2020 May 18.

Gastroenterology Department, Tenth People's Hospital of Tongji University, Shanghai, China.

Aim: The aim of this study was to investigate the significance of positive tuberculosis interferon gamma release assay (TB-IGRA) in the differential diagnosis of intestinal tuberculosis (ITB) and Crohn's disease (CD) patients, and to find a suitable threshold to help distinguishing CD from tuberculosis (TB), so as to provide better recommendations for clinical treatment.

Methods: A retrospective study was performed including 484 patients who underwent TB-IGRA testing for suspected CD or ITB treated in the Shanghai Tenth People's Hospital of Tongji University between January 2015 and May 2018. According to the diagnostic criteria, 307 patients, including 272 CD and 35 ITB patients, were recruited for the final analysis. Read More

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http://dx.doi.org/10.1177/1756284820922003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235651PMC

Application value of ERAS in perioperative period of precise hepatectomy for hepatocellular carcinoma patients.

J BUON 2020 Mar-Apr;25(2):965-971

Department of Surgical Anesthesiology, No.215 Hospital of Shaanxi Nuclear Industry, Xianyang, China.

Purpose: To explore the efficacy and reliability of enhanced recovery after surgery (ERAS) applied in the perioperative period of precise hepatectomy for hepatocellular carcinoma (HCC).

Methods: The propensity score matching and a retrospective cohort study were employed. The clinical and pathological data of 122 hepatocellular carcinoma (HCC) patients with surgical indications admitted to our hospital from March 2014 to March 2016 were collected. Read More

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June 2020
0.706 Impact Factor

[Contrast-Enhanced Ultrasound as a Diagnostic Tool in Diseases of the Digestive Tract].

Authors:
Daniel Weiss

Praxis (Bern 1994) 2020 ;109(8):615-630

Radiologie Spital STS-AG, Thun.

Contrast-Enhanced Ultrasound as a Diagnostic Tool in Diseases of the Digestive Tract Contrast-enhanced ultrasound is a good diagnostic tool in certain gastrointestinal diseases. Inflammation of the gastric and the bowel wall can often be distinguished from neoplastic alterations. Gastric and duodenal stenosis can be depicted with the use of oral contrast, and after stenting the patency can be documented. Read More

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http://dx.doi.org/10.1024/1661-8157/a003488DOI Listing
January 2020

Secondary aorto-duodenal fistula successfully treated with a novel surgical method: A case report.

Int J Surg Case Rep 2020 May 29;72:17-21. Epub 2020 May 29.

Department of Endovascular treatment, Tokushima Red Cross Hospital, Japan.

Introduction: Secondary aorto-duodenal fistula (sADF) is a complication of abdominal aorta artificial blood vessel replacement that often leads to death. However, an optimal operative method has not yet been established. We describe a patient who underwent artificial blood vessel reimplantation and duodenectomy after endovascular aneurysmal repair (EVAR) with positive outcomes. Read More

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http://dx.doi.org/10.1016/j.ijscr.2020.05.041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7276383PMC

Vedolizumab-associated psoriasis: until where does gut selectivity go?

Rev Esp Enferm Dig 2020 Jun 4;112. Epub 2020 Jun 4.

Gastroenterology, Centro Hospitalar Universitário do Porto, Portugal.

Inflammatory Bowel Disease and Psoriasis are chronic inflammatory diseases that share common genotype, clinical course, and immunological features, although its relationship is still unclear. We report a 34-year-old woman with ileal Crohn's disease diagnosed 14 years ago, with the development of extensive, exudative scalp lesions after adalimumab therapy. Biopsies from skin lesions were compatible with vulgar psoriasis. Read More

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http://dx.doi.org/10.17235/reed.2020.6817/2019DOI Listing

Enteral versus parenteral nutrition in the conservative treatment of upper gastrointestinal fistula after surgery: a multicenter, randomized, parallel-group, open-label, phase III study (NUTRILEAK study).

Trials 2020 Jun 2;21(1):448. Epub 2020 Jun 2.

Department of Digestive and Oncological Surgery, Lille University Hospital, Lille, France.

Background: Postoperative upper gastrointestinal fistula (PUGIF) is a devastating complication, leading to high mortality (reaching up to 80%), increased length of hospital stay, reduced health-related quality of life and increased health costs. Nutritional support is a key component of therapy in such cases, which is related to the high prevalence of malnutrition. In the prophylactic setting, enteral nutrition (EN) is associated with a shorter hospital stay, a lower incidence of severe infectious complications, lower severity of complications and decreased cost compared to total parenteral nutrition (TPN) following major upper gastrointestinal (GI) surgery. Read More

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http://dx.doi.org/10.1186/s13063-020-04366-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265255PMC

Cecal Perforation by a Large Gallstone: An Unusual Diagnosis.

Cureus 2020 Apr 27;12(4):e7859. Epub 2020 Apr 27.

General Surgery, Hospital do Litoral Alentejano, Santiago do Cacém, PRT.

Cholecystocolic fistulas are uncommon, with rare cases of colonic obstruction described in the literature and even rarer cases of intestinal perforation due to gallstones. We describe a case of a 73-year-old man who presented to our ED with complaints of diffuse abdominal pain, vomiting, constipation, and fever for the past week. Abdomen CT showed signs of acute perforated appendicitis. Read More

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http://dx.doi.org/10.7759/cureus.7859DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7255080PMC

Crohn's disease: prevalence, MR features, and clinical significance of enteric and colonic sinus tracts.

Eur Radiol 2020 May 26. Epub 2020 May 26.

Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.

Objectives: Enteric and colonic sinus tracts are inflammatory complications that precede intestinal fistulas in patients with Crohn's disease (CD). The aim of this study was to retrospectively determine the prevalence, morphologic features, and outcome of sinus tracts using MR imaging.

Methods: A consecutive cohort of 642 patients with known CD, referred for MR enterography or MR enteroclysis (study period 01/2014-09/2019), was evaluated retrospectively for the presence of sinus tracts, their locations, presence and length of coexisting strictures, bowel wall thickness, CDMI score, upstream dilation, and bowel distension. Read More

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http://dx.doi.org/10.1007/s00330-020-06935-1DOI Listing

Effect of early enteral nutrition on outcomes of trauma patients requiring intensive care.

Chin J Traumatol 2020 Jun 21;23(3):163-167. Epub 2020 Apr 21.

Department of Emergency and Critical Care, First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China. Electronic address:

Purpose: To investigate the effect of early enteral nutrition on outcomes of trauma patients in the intensive care unit (ICU).

Methods: Clinical data of trauma patients in the ICU of Daping Hospital, China from January 2012 to December 2017 was retrospectively analyzed, including patient age, gender, injury mechanism, injury severity score (ISS), nutritional treatment, postoperative complications (wound infection, abdominal abscess, anastomotic rupture, pneumonia), mortality, and adverse events (nausea, vomiting, abdominal distention). Only adult trauma patients who developed bloodstream infection after surgery for damage control were included. Read More

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http://dx.doi.org/10.1016/j.cjtee.2020.04.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296358PMC

Intestinal fistula accompanied by recurrent peritonitis associated with peritoneal dialysis: a case report.

BMC Gastroenterol 2020 May 24;20(1):157. Epub 2020 May 24.

Department of Nephrology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, Jiangsu Province, 210008, China.

Background: Intestinal perforation from peritoneal dialysis is rare, but the resulting complications are serious. Some patients do not necessarily have symptoms, and it can be difficult to differentiate their condition from PD-related (peritoneal dialysis-related) peritonitis, which may lead to misdiagnosis. Here we report a peritoneal dialysis patient with intestinal fistula associated with recurrent peritonitis. Read More

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http://dx.doi.org/10.1186/s12876-020-01303-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7245831PMC

Effect of platelet-rich plasma on colon anastomosis in rats in which hyperthermic intra-peritoneal chemotherapy was performed using 5-fluorouracil.

ANZ J Surg 2020 May 21. Epub 2020 May 21.

Department of Medical Microbiology, Adiyaman University Training and Research Hospital, Adiyaman, Turkey.

Background: Hyperthermic intra-peritoneal chemotherapy (HIPEC) performed in patients with peritoneal carcinomatosis has a cytotoxic effect on tumour cells. This cytotoxic effect also adversely affects the wound healing of anastomosis, which is frequently undertaken in this patient group, and causes anastomotic leakage and intestinal fistulas. Platelet-rich plasma (PRP) gel has been used in wound healing and has shown efficacy. Read More

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http://dx.doi.org/10.1111/ans.15993DOI Listing

[Extraintestinal manifestations and intestinal complications in children with Crohn's disease: an analysis of 54 cases].

Zhongguo Dang Dai Er Ke Za Zhi 2020 May;22(5):478-481

Department of Pediatrics, Peking Union Medical College Hospital, Beijing 100730, China.

Objective: To summarize the extraintestinal manifestations and intestinal complications in children with Crohn's disease (CD).

Methods: The clinical data of 54 children who were diagnosed with CD in Peking Union Medical College Hospital from January 2008 to December 2018 were collected for retrospective analysis of extraintestinal manifestations and intestinal complications. According to the location of the lesion, the children were divided into ileocolonic group (30 cases), colonic group (6 cases), and ileal group (18 cases). Read More

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Morbidity and Mortality of Typhoid Intestinal Perforation Among Children in Sub-Saharan Africa 1995-2019: A Scoping Review.

World J Surg 2020 May 19. Epub 2020 May 19.

Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD, USA.

Background: Typhoid fever incidence and complications, including intestinal perforation, have declined significantly in high-income countries, with mortality rates <1%. However, an estimated 10.9 million cases still occur annually, most in low- and middle-income countries. Read More

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http://dx.doi.org/10.1007/s00268-020-05567-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236653PMC

Pyoderma gangrenosum confused with congenital preauricular fistula infection: A case report.

World J Clin Cases 2020 May;8(9):1679-1684

Department of Otolaryngology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.

Background: Pyoderma gangrenosum resulting from or associated with congenital preauricular fistula is rarely reported.

Case Summary: We report a rare case of pyoderma gangrenosum misdiagnosed as preauricular fistula infection. To our knowledge, this is the first report to describe pyoderma gangrenosum originating from the site of preauricular fistula. Read More

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http://dx.doi.org/10.12998/wjcc.v8.i9.1679DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7211529PMC

Chyme Reinfusion in Intestinal Failure Related to Temporary Double Enterostomies and Enteroatmospheric Fistulas.

Nutrients 2020 May 11;12(5). Epub 2020 May 11.

Réadaptation Digestive et Nutritionnelle, Clinique Saint Yves 4 rue Adolphe Leray CS54435, 35044 RENNES Cedex, France.

Some temporary double enterostomies (DES) or entero-atmospheric fistulas (EAF) have high output and are responsible for Type 2 intestinal failure. Intravenous supplementations (IVS) for parenteral nutrition and hydration compensate for intestinal losses. Chyme reinfusion (CR) artificially restores continuity pending surgical closure. Read More

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http://dx.doi.org/10.3390/nu12051376DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7285017PMC

Early Active Irrigation-Suction Drainage among Enterocutaneous Fistulas Patients with Chronic Critical Illness: A Retrospective Cohort Study.

Am Surg 2020 Apr;86(4):346-353

From the *Department of Surgery, Jinling Hospital, Nanjing Medical University, Nanjing, P R China and.

Enterocutaneous fistulas (ECFs) requiring admission to ICU is a serious surgical complication. A growing number of patients survive ECFs but remain chronically critically ill. The aim of our study was to investigate the risk factors of hospital death in patients with chronic critical illness attributed to ECFs. Read More

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Porcine Small Intestinal Submucosa Mesh to Treat Inguinal Hernia in Young Adults Using Laparoscopic Inguinal Hernia Repair: A Retrospective Controlled Study.

Surg Laparosc Endosc Percutan Tech 2020 May 1. Epub 2020 May 1.

Department of Hernia and Abdominal Wall Surgery, Beijing Chaoyang Hospital, Capital Medical University.

Background: The authors evaluated the effects and clinical value of small intestinal submucosa (SIS) mesh to treat inguinal hernia in young adults by the laparoscopic method.

Methods: The clinical data of 357 cases with inguinal hernia using SIS mesh in our hospital were analyzed retrospectively from June 2014 to June 2018. All cases were divided into 2 groups according to the surgical method. Read More

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http://dx.doi.org/10.1097/SLE.0000000000000806DOI Listing

Consistency of Trans-Abdominal and Water-Immersion Ultrasound Images of Diseased Intestinal Segments in Crohn's Disease.

Diagnostics (Basel) 2020 Apr 29;10(5). Epub 2020 Apr 29.

Inflammatory Bowel Disease Center, Yokohama City University Medical Center, Yokohama 232-0024, Japan.

The aim of this study is to clarify whether trans-abdominal ultrasound (TAUS) can reflect actual intestinal conditions in Crohn's disease (CD) as effectively as water-immersion ultrasound (WIUS) does. This retrospective study enrolled 29 CD patients with 113 intestinal lesions. Five ultrasound (US) parameters (distinct presence/indistinct presence/disappearance of wall stratification in the submucosal and mucosal layers; thickened submucosal layer; irregular mucosal surface; increased fat wrapping around the bowel wall; and fistula signs) that may indicate different states in CD were determined by TAUS and WIUS for the same lesion. Read More

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http://dx.doi.org/10.3390/diagnostics10050267DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7277370PMC

Succinate Activates EMT in Intestinal Epithelial Cells through SUCNR1: A Novel Protagonist in Fistula Development.

Cells 2020 Apr 29;9(5). Epub 2020 Apr 29.

Departamento de Farmacología and CIBER, Facultad de Medicina, Universidad de Valencia, 46010 València, Spain.

The pathogenesis of Crohn's disease-associated fibrostenosis and fistulas imply the epithelial-to-mesenchymal transition (EMT) process. As succinate and its receptor (SUCNR1) are involved in intestinal inflammation and fibrosis, we investigated their relevance in EMT and Crohn's disease (CD) fistulas. Succinate levels and SUCNR1-expression were analyzed in intestinal resections from non-Inflammatory Bowel Disease (non-IBD) subjects and CD patients with stenosing-B2 or penetrating-B3 complications and in a murine heterotopic-transplant model of intestinal fibrosis. Read More

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http://dx.doi.org/10.3390/cells9051104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290938PMC

The Role of Immune and Epithelial Stem Cells in Inflammatory Bowel Disease Therapy

Curr Drug Targets 2020 05 3. Epub 2020 May 3.

Department of Biochemistry, Faculty of Medicine, Medical University of Lodz, Lodz. Poland.

Background: Inflammatory Bowel Disease (IBD) is categorized as Crohn's disease (CD) and Ulcerative colitis (UC) and it is characterized by chronic inflammation in the gastrointestinal (GI) tract. Relapsing symptoms, including abdominal pain, increased stool frequency, loss of appetite as well as anemia contribute to significant deterioration of quality of life. IBD treatment encompasses chemotherapy (e. Read More

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http://dx.doi.org/10.2174/1389450121666200504074922DOI Listing

GanMeijian ameliorates lipid accumulation and oxidative damage in alcoholic fatty liver disease in Wistar rats.

Life Sci 2020 Aug 30;255:117721. Epub 2020 Apr 30.

Department of Microbial and Biochemical Pharmacy, School of Pharmacy, Southwest Medical University, Luzhou 646000, Sichuan, China. Electronic address:

Alcoholic fatty liver disease (AFLD), a major public health problem, has drawn clinical and scientific attention. The study aims to investigate the effect of Ganmeijian [crude extract of malt root, phosphoesterase complex (Pho)] on AFLD, and explore the possible mechanisms. An AFLD rat model was made. Read More

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http://dx.doi.org/10.1016/j.lfs.2020.117721DOI Listing

National Landscape of Unplanned 30-Day Readmission Rates for Acute Non-hemorrhagic Diverticulitis: Insight from National Readmission Database.

Dig Dis Sci 2020 May 1. Epub 2020 May 1.

Department of Gastroenterology and Hepatobiliary Disease, Westchester Medical Center at New York Medical College, 100 Woods Road, Valhalla, NY, 10595, USA.

Background: Early readmissions are an important indicator of the quality of care. Limited data exist describing hospital readmissions in acute diverticulitis. The study aimed to describe unplanned, 30-day readmissions among adult acute diverticulitis patients and to assess readmission predictors. Read More

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http://dx.doi.org/10.1007/s10620-020-06284-5DOI Listing

Management of entero-atmospheric fistulas by chyme reinfusion: A retrospective study.

Clin Nutr 2020 Apr 2. Epub 2020 Apr 2.

Nutritional and Digestive Rehabilitation Unit, Clinique Saint-Yves, Rennes, France.

Background & Aims: High output entero-cutaneous fistulas may lead to intestinal failure with parenteral nutrition (PN) as the gold standard treatment to prevent dehydration and malnutrition. However in case of entero-atmospheric fistula (EAF) with the distal limb of the fistula accessible, chyme reinfusion (CR), a technique that restores artificially digestive continuity can be performed until the surgical repair. Our aim was to study the efficacy of CR in EAF regarding nutritional status, intestinal function, PN weaning and liver tests. Read More

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http://dx.doi.org/10.1016/j.clnu.2020.03.030DOI Listing

Open abdomen treatment for complicated intra-abdominal infection patients with gastrointestinal fistula can reduce the mortality.

Medicine (Baltimore) 2020 Apr;99(16):e19692

State Key Laboratory of Cancer Biology, National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive Diseases, Xijing Hospital, Fourth Military Medical University.

To evaluate the effect of the open abdomen (OA) and closed abdomen (CA) approaches for treating intestinal fistula with complicated intra-abdominal infection (IFWCIAI), and analyze the risk factors in OA treatment.IFWCIAI is associated with high mortality rates and healthcare costs, as well as longer postoperative hospital stay. However, OA treatment has also been linked with increased mortality and development of secondary intestinal fistula. Read More

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http://dx.doi.org/10.1097/MD.0000000000019692DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220662PMC

Novel chyme reinfusion device for gastrointestinal fistulas and stomas: feasibility study.

Br J Surg 2020 Apr 18. Epub 2020 Apr 18.

Department of Surgery, Auckland, New Zealand.

Background: High-output enterostomies and enteroatmospheric fistulas are common causes of intestinal failure, and may necessitate parenteral nutrition and prolonged hospital stay. Reinfusing lost chyme into the distal gut is known to be beneficial, but implementation has been limited because manual reinfusion is unpleasant and labour-intensive, and no devices are available. A new device is presented for reinfusing chyme easily and efficiently, with first-in-human data. Read More

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http://dx.doi.org/10.1002/bjs.11516DOI Listing

Surgical management of acquired rectourethral fistula: a retrospective analysis of 52 consecutive patients.

Tech Coloproctol 2020 Apr 16. Epub 2020 Apr 16.

Department of Urology, University Hospitals Leuven, KU Leuven, Leuven, Belgium.

Background: Acquired rectourethral fistula (RUF) is an uncommon complication mostly resulting from surgery or radiation. Standardization of the surgical management is lacking. The aim of this study was to report our experience with surgery for RUF. Read More

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http://dx.doi.org/10.1007/s10151-020-02214-9DOI Listing

Association of bacteria in pancreatic fistula fluid with complications after pancreatic surgery.

BJS Open 2020 Jun 16;4(3):432-437. Epub 2020 Apr 16.

Department of Surgery, Munich, Germany.

Background: Pancreatic fistula (PF) is a common complication after pancreatic surgery. It is unclear how microbes in PF fluid affect outcomes and which microbes are present after pancreatoduodenectomy (PD) and distal pancreatectomy (DP). The aim of this study was to compare the microbiological spectrum of PF fluid after PD versus DP, and its association with postoperative complications. Read More

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http://dx.doi.org/10.1002/bjs5.50272DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260411PMC

Aortoduodenal Fistula After Endovascular Abdominal Aortic Aneurysm Repair.

Vasc Endovascular Surg 2020 Jul 15;54(5):445-448. Epub 2020 Apr 15.

Department of Cardiovascular Surgery, Morinomiya Hospital, Joto-ku, Osaka, Japan.

Aortoduodenal fistula after endovascular treatment of abdominal aortic aneurysm is a very rare but life-threatening complication. Herein, we describe 4 cases of aortoduodenal fistula diagnosed at 15 to 78 months after the index aortic intervention, all successfully treated by surgery. All patients underwent primary repair of the duodenal wall, creation of tube duodenostomy, stent graft removal, and in situ reconstruction using a rifampicin-soaked prosthesis. Read More

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http://dx.doi.org/10.1177/1538574420918969DOI Listing

Gastrointestinal bleeding as a result of entero-iliac fistula due to intestinal foreign body.

Ann Med Surg (Lond) 2020 May 1;53:20-22. Epub 2020 Apr 1.

Department of Surgery, San Salvatore Hospital. Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Italy.

Ingested toothpicks are a relatively rare event, but they may cause serious gut injuries and can be listed among rare causes of perforation, peritonitis, sepsis or death. Unless the foreign bodies were intentionally swallowed, many patients who ingested them fail to remember the event and they do not refer it during the medical history collection; this makes diagnosis problematic. In this work, a case of perforation of the sigmoid colon is described, caused by a toothpick ingestion. Read More

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http://dx.doi.org/10.1016/j.amsu.2020.03.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7149406PMC

Total Pancreatectomy for Malignant Intraductal Papillary Mucinous Neoplasm (IPMN) Complicated by Gastropancreatic Fistulae.

Case Rep Surg 2020 24;2020:8547526. Epub 2020 Mar 24.

Department of Surgery, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka.

Background: Intraductal papillary mucinous neoplasms (IPMN) of the pancreas complicated by fistula formation to adjacent organs are an uncommon phenomenon. We present an IPMN of the pancreas with malignant transformation and multiple fistulae to the stomach and duodenum. . Read More

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http://dx.doi.org/10.1155/2020/8547526DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7132345PMC

[Submucosal laser ablation of internal hemorrhoids].

Khirurgiia (Mosk) 2020 (3):89-96

A.N. Ryzhikh State Scientific Center of Coloproctology of the Ministry of Health of Russia, Moscow, Russia.

Objective: To analyze efficacy and safety of submucosal laser ablation of internal hemorrhoids (SLT).

Material And Methods: Systematic review included 10 articles published in electronic databases PubMed, Cochrane Library, Elibrary until January 2019. There were only full-text publications from prospective clinical trials devoted to submucosal laser ablation in the treatment of hemorrhoids. Read More

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http://dx.doi.org/10.17116/hirurgia202003189DOI Listing

New Compressible Barrier Devices for Enteric Fistula and Ostomy Effluent Isolation.

Surg Technol Int 2020 May;36:77-81

Department of General Surgery, Regions Hospital, St. Paul, Minnesota, John F. Perry, Jr. Chair of Trauma Surgery, University of Minnesota, Minneapolis, Minnesota.

Enteric fistulas are among the most dreaded surgical complications. Controlling fistula effluent and protecting the surrounding tissue is a difficult long-term endeavor that can consume significant clinical resources. This article describes novel, one-piece compressible isolation devices that can be used to manage the body surface around an enteric fistula, stoma, or drain tube to seal and protect the patient from effluent. Read More

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Impact of therapies on bowel damage in Crohn's disease.

United European Gastroenterol J 2020 May 20;8(4):410-417. Epub 2020 Feb 20.

IBD Centre, Department of Gastroenterology, Humanitas Clinical and Research Institute, Milan, Italy.

Crohn's disease (CD) is a chronic inflammatory bowel disease that usually progresses to bowel damage, defined as strictures, fistulas and abscesses. These complications require intestinal resection and lead to further irreversible structural damage. Cross-sectional imaging, such as magnetic resonance imaging, computed tomography and ultrasound, are accurate in assessing intestinal damage at a definite time point and the progression of damage over time. Read More

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http://dx.doi.org/10.1177/2050640620908696DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226700PMC

Acute histologic inflammatory activity and postoperative outcomes in pediatric patients with ulcerative colitis.

Am J Surg 2020 04 11;219(4):592-597. Epub 2020 Mar 11.

Nationwide Children's Hospital, Division of Pediatric Surgery, 700 Children's Dr., Columbus, OH, 43205, USA; The Ohio State University College of Medicine, Department of Surgery, 395 W. 12th Ave, Columbus, OH, 43210, USA. Electronic address:

Background: The aim of this study was to determine whether acute histologic inflammatory activity at the rectal margin predicts postoperative complications in children with ulcerative colitis following ileal pouch-anal anastomoses (IPAA).

Methods: Patients who underwent IPAA following previous total abdominal colectomy for ulcerative colitis between 2006 and 2014 were included. Data collected included demographics, operative and postoperative data, histologic grading of the rectal margin at time of IPAA, and stooling outcomes at one, six and 12 months following ileostomy closure. Read More

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http://dx.doi.org/10.1016/j.amjsurg.2020.02.054DOI Listing

Improved simple T-cannula technique to facilitate surgery and daily skin care of growing pigs.

J Anim Sci 2020 Apr;98(4)

Institute of Animal Science, University of Hohenheim, Stuttgart, Germany.

In order to further increase the stability of the cannula behind the ribs and to facilitate cannula exteriorization in growing pigs, the present study aimed to evaluate whether elongation of the cannula flange could increase the stability of the cannula behind the ribs and to develop a tool to improve the exteriorization of the cannula through the ribs. Moreover, it was assessed whether a special skin protection paste and soft polyurethane foam material used in daily skin care could prevent erythema around the fistula. The feasibility of both, the modified simple T-cannula and daily skin care procedure, was evaluated in a digestibility experiment. Read More

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http://dx.doi.org/10.1093/jas/skaa091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7135948PMC

Gallstone Ileus: An Unusual Cause of Intestinal Obstruction.

Cureus 2020 Mar 15;12(3):e7284. Epub 2020 Mar 15.

Surgery, The Wollongong Hospital, Wollongong, AUS.

Gallstone ileus is an uncommon complication of gallstones and a rare cause of intestinal obstruction. Typically as a result of the formation of cholecystoduodenal fistula, surgical removal of the gallstone is the mainstay of treatment in order to relieve the intestinal obstruction. A 34-year-old male with no history of cholelithiasis presented with features of a small bowel obstruction. Read More

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http://dx.doi.org/10.7759/cureus.7284DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7077742PMC