7,159,366 results match your criteria Interventional Cardiology [Journal]
Sportverletz Sportschaden 2018 Dec 11;32(4):264-271. Epub 2018 Dec 11.
Hochschule für öffentliche Verwaltung und Finanzen Ludwigsburg.
Background: In Germany, widespread use is made of dietary supplements (DS) to improve the individual health status, especially among patients diagnosed with certain conditions, elderly people and athletes. Legal aspects as well as health risks related to DS purchased via the internet are rarely analysed in Germany.
Purpose: We aim to provide a review of the respective literature focusing on health risks, legal aspects und consumer information related to the internet retailing of DS. Read More
Sportverletz Sportschaden 2018 Dec 11;32(4):251-259. Epub 2018 Dec 11.
Department of Sportsmedicine, Department of Orthopedic and Trauma Surgery, Klinikum Bamberg, Bamberg, Germany.
Rationale And Objectives: Pulley ruptures are the most common injuries in sport climbing. Ruptures of the A2 and A4 pulleys have been studied extensively, and ultrasound has proven to be a highly sensitive and specific tool for their diagnosis. However, the correct diagnosis of A3 pulley ruptures continues to be a challenge. Read More
Zentralbl Chir 2018 Dec 11. Epub 2018 Dec 11.
Institut für Diagnostische und Interventionelle Radiologie, Universitätsklinikum Jena, Deutschland.
True visceral artery aneurysms (VAA) and visceral artery pseudoaneurysms (VAPA) are located in the celiac trunk, the superior mesenteric artery and inferior mesenteric artery. In addition to surgical treatment, endovascular embolisation therapy of visceral aneurysms and pseudoaneurysms is an alternative interventional method that has developed precipitously over the last two decades and is considered a first-choice method in many centres. The procedure is characterised by a high technical success rate with a low complication rate. Read More
Laryngorhinootologie 2018 Dec 11. Epub 2018 Dec 11.
Universitatsklinikum Giessen und Marburg Standort Giessen HNO.
Objective: In 2009 a nationwide survey revealed that only 24 % of the German ENT-hospitals performed sialendoscopy. In 2016 the survey was repeated to reevaluate the actual ranking of sialendoscopy in Germany.
Material Und Methods: Again, the same questionnaire as in 2009 was sent to all German ENT-hospitals. Read More
Fortschr Neurol Psychiatr 2018 Dec 11. Epub 2018 Dec 11.
Ruhr-Universität Bochum, Psychiatrie.
Objective: Ullrich-Turner Syndrome (UTS; Turner Syndrome (TS)) is a X-chromosomal disorder, which is characterized by a variety and heterogenous clinical conditions. Although it is not typically associated with neuropsychiatric disorders, several case reports describe concomitant TS and neuropsychiatric abnormalities that may represent a pathogenetic link.
Methods: Based on the case representation of woman with TS and co-occurrent schizoaffective disorder we discuss possible relationships and current literature. Read More
Med Sci Monit 2018 Dec 11;24:8977-8983. Epub 2018 Dec 11.
Department of Allergy and Immunology, Dr. Ersin Arslan Education and Research Hospital, Gaziantep, Turkey.
BACKGROUND Subcutaneous immunotherapy (SCIT) in allergic rhinitis (AR) and asthma is a very effective treatment, but adherence is still a serious problem. Studies addressing real-life adherence to SCIT are rare in the literature. The aim of this study was to evaluate the adherence to SCIT in AR and asthma. Read More
Oncol Res Treat 2018 Dec 12;42(1-2). Epub 2018 Dec 12.
Introduction: Breast cancer is responsible for more than 50% of cutaneous metastases. One of the treatment options is electrochemotherapy (ECT). It is an effective method of local tumor ablation through the application of electroporation. Read More
Obes Facts 2018 Dec 11;11(6):466-474. Epub 2018 Dec 11.
Department of General and Visceral Surgery, Hospital Mittelbaden, Baden-Baden,
Objective: Obesity surgery provides sustainable weight loss, improvement of comorbidities, and improved quality of life (QOL). There is few evidence on the patient perspective and goals. This study compared expected and achieved weight loss, body shape, and QOL. Read More
Obes Facts 2018 Dec 11;11(6):454-464. Epub 2018 Dec 11.
Clinic of Internal Medicine, Jessenius Faculty of Medicine in Martin (JFM CU), Comenius University in Bratislava, Bratislava, Slovakia.
Background: To report changes in body composition and biochemical parameters in patients with type 1 diabetes mellitus (T1D) after switching from multiple daily injection (MDI) to continuous subcutaneous insulin infusion (CSII).
Methods: 31 patients switched over from MDI to CSII. Body composition, biochemical parameters, glycaemic variability (GV) and level of physical activity were evaluated before and 6 months on CSII. Read More
Oncol Res Treat 2018 Dec 12;42(1-2). Epub 2018 Dec 12.
Background: There are no standard cytotoxic treatments for non-small-cell lung cancer (NSCLC) patients beyond third-line therapy. The purpose of this study was to evaluate the efficacy and safety of amrubicin in pretreated NSCLC patients.
Methods: The records of NSCLC patients who received amrubicin monotherapy as a third or later line of chemotherapy at Shizuoka General Hospital between April 2007 and March 2015 were retrospectively reviewed. Read More
ORL J Otorhinolaryngol Relat Spec 2018 Dec 11;81(1):16-23. Epub 2018 Dec 11.
Department of Otolaryngology and Head and Neck Surgery, Wakayama University Hospital, Wakayama, Japan.
Background/aims: The aim of this study was to observe the relationship between the gene expression profiles of tumor necrosis factor (TNF)-α and endothelin (EDN)-1 and obstructive sleep apnea (OSA).
Methods: A prospective, cross-sectional study performed at a tertiary-care academic center; 108 patients with snoring and day-time sleeplessness were included in this study carried out in the Otolaryngology Department. All patients were evaluated with 1-night polysomnography (PSG). Read More
Dement Geriatr Cogn Disord 2018 Dec 11;46(5-6):358-370. Epub 2018 Dec 11.
Department of Physical Therapy and Graduate Institute of Rehabilitation Science, College of Medicine, Chang Gung University, Taoyuan, Taiwan.
Background: Tai Chi (TC) is a Chinese mind-body exercise with proven physical and psychological benefits. A modified TC via virtual reality (VR) may be suitable for the elderly owing to the immediate guidance and feedback regarding movement accuracy. This study explored the cognitive and physical effects of a VR-based TC (VRTC) exercise program on older adults with cognitive impairment (CI). Read More
Audiol Neurootol 2018 Dec 11;23(5):277-284. Epub 2018 Dec 11.
Department of Otorhinolaryngology - Head and Neck Surgery, Taipei Veterans General Hospital, Taipei, Taiwan.
Objective: The purpose of this retrospective study was to investigate the difference in treatment outcomes for patients with idiopathic sudden sensorineural hearing loss (SSNHL) undergoing concurrent or sequential intravenous (IV) and intratympanic (IT) steroid therapies.
Methods: Patients with idiopathic SSNHL admitted to Taipei Veterans Hospital from August 2011 to August 2012 were enrolled. Patients were treated with both IV dexamethasone 5 mg b. Read More
Med Princ Pract 2018 Dec 11. Epub 2018 Dec 11.
Objective: To investigate the influence of sleep apnea on ECG and blood pressure monitoring parameters in patients with acute heart failure (AHF).
Methods: 51 hospitalized patients with AHF (13 women, 38 men, mean age 60.8 years) underwent 24-hour combined monitoring of ECG and blood pressure and sleep apnea testing before discharge. Read More
Kidney Blood Press Res 2018 Dec 7;43(6):1822-1831. Epub 2018 Dec 7.
Division of Nephrology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung,
Background/aims: Hyperglycemia and hyperuricemia are two major disorders of Metabolic syndrome. Kidney plays a crucial role in maintaining the homeostasis of uric acid and glucose. The aim of the study was to examine the changes of renal glucose and uric acid transporters in animals with metabolic syndrome. Read More
Cell Physiol Biochem 2018 11;51(5):2484-2495. Epub 2018 Dec 11.
Department of Hepatic Surgery, The Third Affiliated Hospital, Sun Yat-sen University, Guangdong, China.
Background/aims: The age-bilirubin-international normalized ratio-creatinine (ABIC) score, which is a predictive model commonly used for alcoholic hepatitis, has not yet been studied in acute-on-chronic hepatitis B liver failure (HBV-ACLF). We aimed to investigate the predictive value of the ABIC score in patients with HBV-ACLF.
Methods: This retrospective study involved 398 patients diagnosed with HBV-ACLF, who were divided into a training cohort of 305 patients and a validation cohort of 93 patients. Read More
Cell Physiol Biochem 2018 11;51(5):2472-2483. Epub 2018 Dec 11.
Spine Tumor Center, Department of Orthopedic Oncology, Changzheng Hospital, Second Military Medical University, Shanghai, China.
Background/aims: Giant cell tumor of bone (GCTB), one of the most common primary bone tumors, leads to extensive bone destruction. However, the mechanisms underlying GCTB progression remain elusive and prognostic factors and treatment targets are required. In the current study, we explored the function of the chemokine family member CCL20 in GCTB progression. Read More
Cell Physiol Biochem 2018 11;51(5):2456-2471. Epub 2018 Dec 11.
Background/aims: Skin photoaging is primarily caused by the functional attrition of skin stem cells. The skin stem cell niche plays an important role in maintaining stem cell survival and behaviour. In our study, we hypothesized that UVB irradiation induces skin photoaging by changing skin stem cell niches and that transferred adipose-derived stem cells (ADSCs) can remodel the niches by affecting the BMP signalling pathway and transdifferentiating into skin stem cells. Read More
Cell Physiol Biochem 2018 11;51(5):2445-2455. Epub 2018 Dec 11.
Key Laboratory of Epigenetics and Oncology, the Research Center for Preclinical Medicine, Southwest Medical University, Luzhou,
Background/aims: Familial exudative vitreoretinopathy (FEVR) is a complex hereditary eye disorder characterized by incomplete development of the retinal vasculature, thereby affecting retinal angiogenesis.
Methods: In this study, a Chinese autosomal dominant FEVR pedigree was recruited. Ophthalmic examinations were performed, targeted next-generation sequencing was used to identify the causative gene, and Sanger sequencing was conducted to verify the candidate mutation. Read More
Cell Physiol Biochem 2018 11;51(5):2421-2433. Epub 2018 Dec 11.
College of Veterinary Medicine, Sichuan Agricultural University, Ya'an, China.
Background/aims: Excessive fluoride intake can induce cytotoxicity, DNA damage and cell-cycle changes in many tissues and organs, including the kidney. However, the underlying molecular mechanisms of fluoride-induced renal cell-cycle changes are not well understood at present. In this study, we used a mouse model to investigate how sodium fluoride (NaF) induces cell-cycle changes in renal cells. Read More
Cell Physiol Biochem 2018 11;51(5):2397-2420. Epub 2018 Dec 11.
Research Center for Nutrition and Food Safety, Institute of Military Preventive Medicine, Third Military Medical University, Chongqing Key Laboratory of Nutrition and Food Safety, Chongqing,
Background/aims: Lipid droplets (LDs) are dynamic organelles that store neutral lipids during times of energy excess, and an increased accumulation of LDs in the liver is closely linked to hepatic steatosis. Our previous studies suggested that resveratrol (RSV) supplement could improve hepatic steatosis, but the underlying mechanism, particularly which related to LD accumulation, has not yet been elucidated.
Methods: A high-fat diet (HFD) and palmitic acid were used to induce hepatic steatosis in mouse liver and hepatocytes, respectively. Read More
Cell Physiol Biochem 2018 7;51(5):2359-2376. Epub 2018 Dec 7.
Background/aims: The aim of our study is to investigate the molecular mechanism by which mammalian STE20-like kinase 1 (Mst1) participates in renal I/R injury through modifying mitophagy and the AMPK-YAP signalling pathway.
Methods: WT mice and Mst1-knockout mice were subjected to renal ischaemia-reperfusion (I/R) in vivo. In vitro, the hypoxia-reoxygenation model was used with renal tubular epithelial cells to mimic renal I/R injury. Read More
Cell Physiol Biochem 2018 7;51(5):2341-2358. Epub 2018 Dec 7.
Key Laboratory of the Model Animal Research, Animal Core Facility of Nanjing Medical University, Nanjing Medical University, Nanjing,
Background/aims: This study investigated the effect of consecutive superovulation on the ovaries and established a premature ovarian failure (POF) model in mice.
Methods: The mouse POF model was induced by 5-15 consecutive superovulation treatments with pregnant mare serum gonadotropin (PMSG), human chorionic gonadotropin (HCG) and prostaglandin F2α (PGF2α). Normal adult mice were compared with mice displaying natural ovarian aging. Read More
Cell Physiol Biochem 2018 7;51(5):2324-2340. Epub 2018 Dec 7.
Department of Prevention Medicine, School of Public Health, Mudanjiang Medical College, Mudanjiang City,
Background/aims: Circular RNAs (circRNAs) are key regulators in the development and progression of human cancers, however its role in non-small cell lung cancer (NSCLC) tumorigenesis is not well understood. The aim of this study is to identify the expression level of circPVT1 in NSCLC and further investigated its functional relevance with NSCLC progression both in vitro and in vivo.
Methods: Quantative real-time PCR was used for the measurement of circPVT1 in NSCLC specimens and cell lines. Read More
Cell Physiol Biochem 2018 7;51(5):2309-2323. Epub 2018 Dec 7.
Department of Orthopedic Surgery, ShengJing Hospital, China Medical University, ShenYang,
Background/aims: Chondrocyte apoptosis is a central pathological feature of cartilage in osteoarthritis (OA). Accumulating evidence suggests that calcium ions (Ca2+) are an important regulator of apoptosis. Previously, we reported that the transient receptor potential channel vanilloid (TRPV5) is upregulated in monoiodoacetic acid (MIA)-induced OA articular cartilage. Read More
Cell Physiol Biochem 2018 7;51(5):2290-2308. Epub 2018 Dec 7.
Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, Guangzhou,
Background/aims: Increasing evidence has demonstrated the novel roles of mesenchymal stem cells (MSCs) in immunotherapy. However, difficulty in acquiring these cells and possible ethical issues limited their application. Recently, we have isolated a unique MSC population from dental follicles with potent stem cell-like properties. Read More
Cell Physiol Biochem 2018 7;51(5):2275-2289. Epub 2018 Dec 7.
Department of Neurosurgery, The First Affiliated Hospital of Kunming Medical University, Kunming,
Background/aims: Parkinson's disease (PD) is a frequently occurring condition that resulted from the loss of midbrain neurons, which synthesize the neurotransmitter dopamine. In this study, we established mouse models of PD to investigate the expression of microRNA-128 (miR-128) and mechanism through which it affects apoptosis of dopamine (DA) neurons and the expression of excitatory amino acid transporter 4 (EAAT4) via binding to axis inhibition protein 1 (AXIN1).
Methods: Gene expression microarray analysis was performed to screen differentially expressed miRNAs that are associated with PD. Read More
Cell Physiol Biochem 2018 7;51(5):2262-2274. Epub 2018 Dec 7.
Background/aims: Long noncoding RNAs (lncRNAs) are aberrantly expressed in multiple malignant tumors involved in tumor growth and metastasis. Accumulating data show that small nucleolar RNA host gene (SNHG) 1/12/20 plays a key role in the progression of hepatocellular carcinoma (HCC). However, the molecular mechanisms by which SNHG8 contributes to HCC remain elusive and merit exploration. Read More
Cell Physiol Biochem 2018 7;51(5):2250-2261. Epub 2018 Dec 7.
Division of Cardiovascular Surgery, Department of Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
Background/aims: Diabetes is associated with increased incidence of myocardial dysfunction, which is partly characterized by interstitial and perivascular fibrosis. Cardiac fibroblasts have been identified as an important participant in the development of cardiac fibrosis. Exposure of cultured cardiac fibroblasts to high glucose resulted in increased collagen synthesis. Read More
Cell Physiol Biochem 2018 7;51(5):2237-2249. Epub 2018 Dec 7.
Department of Biomedical and Specialty Surgical Sciences, University of Ferrara, Ferrara,
Background/aims: Mesenchymal stromal cells (MSCs) hold considerable promise in bone tissue engineering, but their poor survival and potency when in vivo implanted limits their therapeutic potential. For this reason, the study on culture conditions and cellular signals that can influence the potential therapeutic outcomes of MSCs have received considerable attention in recent years. Cell maintenance under hypoxic conditions, in particular for a short period, is beneficial for MSCs, as low O2 tension is similar to that present in the physiologic niche, however the precise mechanism through which hypoxia preconditioning affects these cells remains unclear. Read More
Cell Physiol Biochem 2018 7;51(5):2224-2236. Epub 2018 Dec 7.
Departments of Urology, the Third Affiliated Hospital of SooChow University, Changzhou,
Background/aims: We aimed to study the involvement of circZMYM2 (hsa_circ_0099999) in pancreatic cancer (PC) cell proliferation, apoptosis and invasion and to figured out the underlying mechanism of circZMYM2 regulating miR-335-5p and JMJD2C.
Methods: CircRNA differential expressions in twenty PC samples and paired normal tissue samples were analyzed using Arraystar Human CircRNA microarray V1. CircZMYM2 expression level was determined via qRT-PCR. Read More
Cell Physiol Biochem 2018 7;51(5):2212-2223. Epub 2018 Dec 7.
Department of Internal Medicine, Affiliated Tumor Hospital of Zhengzhou University, Zhengzhou,
Background/aims: TNF-related apoptosis-inducing ligand (TRAIL) is a novel and low-toxic anti-tumor drug used for various cancers. However, cancer cells usually develop mechanisms to acquire the resistance against TRAIL. Among these changes, dysregulation of microRNAs (miRNAs) usually occurs in cancer cells and is responsible for induction of drug resistance. Read More
Cell Physiol Biochem 2018 7;51(5):2198-2211. Epub 2018 Dec 7.
Institute for Brain Research and Rehabilitation, Guangdong Key Laboratory of Mental Health and Cognitive Science, Center for Studies of Psychological Application, South China Normal University, Guangzhou,
Background/aims: Our previous study demonstrated that a deficiency of microRNA 21 (miR-21) protects mice from acute pancreatitis, yet the underlying molecular networks associated with miR-21 in pancreatitis and pancreatitis-associated lung injury remain unexplored.
Methods: We used next generation sequencing to analyze gene expression profiles of pancreatic tissues from wild-type (WT) and miR-21 knockout (KO) mice treated with caerulein by using a 1-day treatment protocol. The Database for Annotation, Visualization, and Integrated Discovery gene annotation tool and Ingenuity Pathway Analysis were used to analyze the molecular pathways, while quantitative real-time PCR, western blotting, and immunohistochemistry were used to explore the molecular mechanisms. Read More
Cell Physiol Biochem 2018 7;51(5):2185-2197. Epub 2018 Dec 7.
Department of Medicine, The University of Chicago, Chicago, Illinois,
Background/aims: VCP-interacting membrane selenoprotein (VIMP), an ER resident selenoprotein, is highly expressed in β-cells, however, the role of VIMP in β-cells has not been characterized. In this study, we studied the relationship between VIMP deficiency and β-cell survival in MIN6 insulinoma cells.
Methods: To determine the role of VIMP in β-cells, lentiviral VIMP shRNAs were used to knock down (KD) expression of VIMP in MIN6 cells. Read More
Cell Physiol Biochem 2018 7;51(5):2172-2184. Epub 2018 Dec 7.
Department of Immunology, Binzhou Medical University, Yantai,
Background/aims: Although red blood cells (RBCs) transfusions can be lifesaving, they are not without risk. RBCs storage is associated with the abnormal metabolism of glutathione (GSH), which may increase the risk of the oxidative damage of RBCs after transfusion. The responsible mechanisms remain unknown. Read More
Kidney Blood Press Res 2018 Dec 7;43(6):1865-1877. Epub 2018 Dec 7.
Department of Internal Cardiology Medicine, Faculty Hospital Brno, Faculty of Medicine, Masaryk University, Brno, Czech Republic.
Background/aims: The rate of incidence and prevalence of acute kidney injury is increasing due to an increased number of patients with heart failure. Therefore it is very pertinent to early detect the level of renal injuries and to make necessary heart failure predictions. Thus the aim of this study is to determine renal functions and prognosis stratification in chronic heart failure patients and importance of Neutrophil Gelatinase-Associated Lipocalin (NGAL), an early diagnostic marker of acute kidney injury, as well as stratification of cardiovascular risk in heart failure patients. Read More
Oncology 2018 Dec 11:1-7. Epub 2018 Dec 11.
Department of Pathology, Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland.
Objectives: Protein levels of the transcription factor nuclear factor erythroid-derived 2-like 2 (Nrf2) and its inhibitor Kelch-like ECH-associated protein 1 (Keap1) have been proposed as prognostic factors in pancreatic ductal adenocarcinomas (PDACs). These cellular redox-state-regulating enzymes are targeted by several microRNAs, including miR-93 and miR-200a.
Methods: We assessed mRNA levels of Nrf2 and Keap1 and tissue expression of miR-93 and miR-200a in 51 patients with surgically treated PDAC. Read More
Audiol Neurootol 2018 Dec 11;23(5):259-269. Epub 2018 Dec 11.
BK21 PLUS Program in Embodiment: Health-Society Interaction, Department of Public Health Sciences, Graduate School, Korea University, Seoul, Republic of Korea.
Previous studies have reported that exposure to lead and cadmium can damage the inner ear receptor, which perceives high-frequency sounds. However, few studies have used the pure-tone average (PTA), including high-frequency ranges, for the estimation of hearing loss caused by lead and cadmium exposure. We estimated hearing loss using the PTA test, in low-frequency, speech frequency, and high-frequency ranges and compared the differences in the results using 3 PTA calculation methods. Read More
Psychopathology 2018 Dec 11:1-8. Epub 2018 Dec 11.
Department of Philosophy, Emory University, Atlanta, Georgia, USA.
Background/aims: Disturbances in first person experience is a broadly noted feature of schizophrenia, which cannot be reduced to the expression of psychopathology. Yet, though categorically linked with profound suffering, these disturbances are often ignored by most contemporary treatment models.
Methods: In this paper, we present a model, which suggests that deficits in metacognition and their later resolution parsimoniously explain the development of self-disturbance and clarify how persons can later recover. Read More
Kidney Blood Press Res 2018 Dec 7;43(6):1852-1864. Epub 2018 Dec 7.
Department of Nephrology, the Second Xiangya Hospital, Central South University, Key laboratory of Kidney disease and Blood Purification in Hunan Province, Changsha,
Background/aims: There is an increasing risk of end-stage renal disease (ESRD) among Asian people with immunoglobulin A nephropathy (IgAN). A computer-aided system for ESRD prediction in Asian IgAN patients has not been well studied.
Methods: We retrospectively reviewed biopsy-proven IgAN patients treated at the Department of Nephrology of the Second Xiangya Hospital from January 2009 to November 2013. Read More
ORL J Otorhinolaryngol Relat Spec 2018 Dec 11;81(1):24-35. Epub 2018 Dec 11.
Maxillo-Facial Surgery Unit, Neurosensorial Department, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy.
Objective: The buccal fat pad (BFP) has been progressively introduced into clinical practice for oral defect reconstruction. This study describes our experience with this technique and compares indications in the literature and outcomes.
Methods: We prospectively enrolled 24 patients presenting oral surgical defects and treated between January 2012 and January 2015 at our institution. Read More
Obes Facts 2018 Dec 11;11(6):501-513. Epub 2018 Dec 11.
Department of Food and Resource Economics, University of Copenhagen, Copenhagen, Denmark.
Objectives: The study investigated whether treatment options for episodic tension-type headache vary among general practitioners (GPs) in Denmark depending on the patients' weight status and gender, and whether these decisions can be explained by the GPs' own anti-fat bias and lifestyle.
Methods: A cross-sectional questionnaire study with responses from 240 GPs on measures of anti-fat bias, healthiness of GPs' lifestyles, and reported patient treatment decisions.
Results: GPs tended to exhibit negative explicit and implicit anti-fat bias. Read More
Eur Surg Res 2018 Dec 11;59(5-6):349-360. Epub 2018 Dec 11.
Background: Enhanced Recovery After Surgery (ERAS) protocols are multimodal perioperative care pathways designed to achieve early recovery after surgical procedures by maintaining preoperative organ function and reducing profound stress responses following surgery [Wilmore and Kehlet: BMJ 2001; 322(7284): 473-6]. Glucagon-like peptide-1 receptor agonists (GLP-1RAgs), such as liraglutide, have recently been widely used as antidiabetic agents in patients with type 2 diabetes (T2D) because they maintain blood glucose at an ideal level throughout the day, including during postprandial periods, thereby improving hypoglycemia and body weight more than insulin therapies. Additionally, the administration of liraglutide may exert cardiovascular, renal, and cerebral protective effects in T2D patients. Read More
Horm Res Paediatr 2018 Dec 11:1-10. Epub 2018 Dec 11.
Division of Pediatric Endocrinology and Diabetes, Department of Pediatrics and Adolescent Medicine, University of Ulm, Ulm, Germany.
Background/aims: Mutations in the DAX1 gene cause X-linked adrenal hypoplasia congenita (AHC) classically associated with hypogonadotropic hypogonadism. Unexpectedly, precocious puberty (PP) has been reported in some cases, its mechanism remaining unclear.
Methods: We longitudinally studied a boy with AHC due to DAX1 gene mutation who developed peripheral PP at age 4. Read More
Cardiorenal Med 2018 Dec 11;9(2):69-82. Epub 2018 Dec 11.
Harold Simmons Center of Kidney Disease Research and Epidemiology, Division of Nephrology and Hypertension, University of California Irvine School of Medicine, Orange, California,
Background: Residual kidney function (RKF) is often expected to inevitably and rapidly decline among hemodialysis patients and, hence, has been inadvertently ignored in clinical practice. The importance of RKF has been revisited in some recent studies. Given that patients with end-stage renal disease now tend to initiate maintenance hemodialysis therapy with higher RKF levels, there seem to be important opportunities for incremental hemo-dialysis by individualizing the dose and frequency according to their RKF levels. Read More
Obes Facts 2018 Dec 11;11(6):475-490. Epub 2018 Dec 11.
Department of Medicine, University of Leipzig, Leipzig,
Background/aims: Altered expression and circulating levels of glutathione peroxidase 3 (GPX3) have been observed in obesity and type 2 diabetes (T2D) across species. Here, we investigate whether GPX3 serum concentrations and adipose tissue (AT) GPX3 mRNA expression are related to obesity and weight loss.
Methods: GPX3 serum concentration was measured in 630 individuals, including a subgroup (n = 293) for which omental and subcutaneous (SC) GPX3 mRNA expression has been analyzed. Read More
Obes Facts 2018 Dec 11;11(6):440-453. Epub 2018 Dec 11.
Nutrition Postgraduate Program, Center for Health Sciences, Federal University of Rio Grande do Norte, Natal,
Objective: This study evaluated the effect of a protein, the isolated Trypsin Inhibitor (TTI) from Tamarindus indica L. seed, as a CCK secretagogue and its action upon food intake and leptin in obese Wistar rats.
Methods: Three groups of obese rats were fed 10 days one of the following diets: Standard diet (Labina®) + water; High Glycemic Index and Load (HGLI) diet + water or HGLI diet + TTI. Read More
Kidney Blood Press Res 2018 Dec 7;43(6):1842-1851. Epub 2018 Dec 7.
Background/aims: We aimed to explore the associations between clinical parameters and long-term allograft outcomes in transplant glomerulopathy (TG) in a large retrospective cohort with long follow-up.
Methods: Clinical and laboratory data at biopsy from 180 cases of TG with an estimated glomerular filtration rate (eGFR)> 15ml/min/1.73m2 from January 2004 to December 2016 at our center were retrospectively analyzed. Read More
Kidney Blood Press Res 2018 Dec 7;43(6):1832-1841. Epub 2018 Dec 7.
Background/aims: Cardiorenal syndrome type 1(CRS1) is a serious clinical condition in patients with acute heart failure (AHF) associated with adverse clinical outcomes. Although several biomarkers for identifying CRS1 have been reported, early and accurate predicting CRS1 still remains a challenge. This study was aimed to develop and validate an individualized predictive nomogram for the risk of CRS1 in patients with AHF. Read More
Med Princ Pract 2018 Dec 10. Epub 2018 Dec 10.
Objective: Diabetic complications involve multiple pathological pathways, including hyperglycemia-induced oxidative stress and inflammation. Combination therapy is usually employed to improve treatment outcomes and to lower potential adverse effects. In this study, we evaluated the effects of antidiabetic and antihypertensive agents, glibenclamide (GLI) and losartan (LT), on diabetes-associated metabolic changes in rats. Read More