340 results match your criteria Intersection Syndrome


Social and structural determinants of youth alcohol use in Tanzania: The role of gender, social vulnerability and stigma.

Glob Public Health 2020 Aug 3:1-13. Epub 2020 Aug 3.

Department of Sociomedical Sciences, Mailman School of Public Health, Columbia University, New York, NY, USA.

Adolescent alcohol use remains an under-addressed population health issue across Africa. Although the literature explores the intersection of alcohol use and vulnerability to HIV and AIDS, there is limited evidence on the gendered uptake and use of alcohol among adolescents. Capturing adolescents' voiced experiences about the societal influences shaping their alcohol usage is essential for identifying contextually relevant interventions to reduce their vulnerability to alcohol and related risky behaviours, such as unsafe sex. Read More

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http://dx.doi.org/10.1080/17441692.2020.1801792DOI Listing

Endothelial activation and dysfunction in metabolic syndrome, type 2 diabetes and coronavirus disease 2019.

Authors:
Melvin R Hayden

J Int Med Res 2020 Jul;48(7):300060520939746

Department of Internal Medicine, University of Missouri-Columbia School of Medicine, Camdenton, Missouri, USA.

The novel coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus-2 infection is a serious global concern. Increased morbidity and mortality is associated with older age, male gender, cardiovascular disease, diabetes, and smoking. As COVID-19 spreads from coastal borders, both state to state and country to country, our understanding of its pathophysiology has evolved. Read More

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http://dx.doi.org/10.1177/0300060520939746DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7391440PMC

Duties toward Patients with Psychiatric Illness.

Hastings Cent Rep 2020 May;50(3):67-69

Patients with psychiatric illness feel the brunt of the intersection of many of our society's and our health care system's disparities, and the vulnerability of this population during the Covid-19 pandemic cannot be overstated. Patients with psychiatric illness often suffer from the stigma of mental illness and receive poor medical care. Many patients with severe and persistent mental illness face additional barriers, including poverty, marginal housing, and food insecurity. Read More

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http://dx.doi.org/10.1002/hast.1139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7361558PMC

COVID-19: Understanding and mitigating trauma in ICU survivors.

Psychol Trauma 2020 Aug 25;12(S1):S100-S104. Epub 2020 Jun 25.

Department of Physical Medicine and Rehabilitation, Johns Hopkins University School of Medicine.

The spread of coronavirus disease 2019 (COVID-19) has placed many individuals in need of critical care, with a high proportion of hospitalized patients being admitted to intensive care units (ICU) to treat acute outcomes of COVID-19 (e.g., respiratory failure via mechanical ventilation). Read More

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http://dx.doi.org/10.1037/tra0000884DOI Listing

Fibularis Intersection Syndrome - A Rare Cause of Lateral Foot Pain in Runners: A Case Report.

Am J Phys Med Rehabil 2020 Jun 22. Epub 2020 Jun 22.

Clinical Fellow, Division of Physical Medicine and Rehabilitation, Department of Medicine, University of Toronto; University Health Network-Toronto Rehabilitation Institute, Toronto, Ontario, Canada; Email: Assistant Professor, Division of Physical Medicine and Rehabilitation, Department of Medicine, University of Toronto; University Health Network-Toronto Rehabilitation Institute, Toronto, Ontario, Canada; Email: PGY5 - Resident, Division of Physical Medicine and Rehabilitation, University of British Columbia, Vancouver, British Columbia, Canada Assistant Professor, Division of Physical Medicine and Rehabilitation, Department of Medicine, University of Toronto; University Health Network-Toronto Rehabilitation Institute and Toronto General Hospital, Toronto, Ontario, Canada; Email:

Running is a common cause of foot and ankle injuries. Accurate diagnosis is important for appropriate management to resolve the issue. For clarity of diagnoses the physician should be able to perform a thorough physical examination in conjunction with point of care ultrasound (POCUS). Read More

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http://dx.doi.org/10.1097/PHM.0000000000001509DOI Listing

Pregnant Women in Trials of Covid-19: A Critical Time to Consider Ethical Frameworks of Inclusion in Clinical Trials.

Ethics Hum Res 2020 Jul 20;42(4):17-23. Epub 2020 Jun 20.

Obstetrician-gynecologist at University Hospitals Cleveland Medical Center working with the Cuyahoga County Board of Health on Covid-19 management.

Ethical issues abound during this unprecedented international public health crisis of Covid-19. While the trade-off between societal and individual interests that occurs at the intersection of public health ethics and clinical ethics affects all populations, this calculus has particular relevance for pregnant women and the question of when they will have access to new Covid-19 therapies and vaccines. Pregnant women are a "scientifically complex" population whose inclusion in clinical research must be done with consideration of the unique state of pregnancy. Read More

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http://dx.doi.org/10.1002/eahr.500060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7323073PMC

Synergistic Effect of WTC-Particulate Matter and Lysophosphatidic Acid Exposure and the Role of RAGE: In-Vitro and Translational Assessment.

Int J Environ Res Public Health 2020 Jun 17;17(12). Epub 2020 Jun 17.

Division of Pulmonary, Department of Medicine, Critical Care and Sleep Medicine, New York University (NYU) School of Medicine, New York, NY 10016, USA.

World Trade Center particulate matter (WTC-PM)-exposed firefighters with metabolic syndrome (MetSyn) have a higher risk of WTC lung injury (WTC-LI). Since macrophages are crucial innate pulmonary mediators, we investigated WTC-PM/lysophosphatidic acid (LPA) co-exposure in macrophages. LPA, a low-density lipoprotein metabolite, is a ligand of the advanced glycation end-products receptor (AGER or RAGE). Read More

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http://dx.doi.org/10.3390/ijerph17124318DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7344461PMC

Further understanding the connection between Alzheimer's disease and Down syndrome.

Alzheimers Dement 2020 07 16;16(7):1065-1077. Epub 2020 Jun 16.

Alzheimer's Therapeutics Research Institute and Department of Neurology, University of Southern California, Los Angeles, California, USA.

Improved medical care of individuals with Down syndrome (DS) has led to an increase in life expectancy to over the age of 60 years. In conjunction, there has been an increase in age-related co-occurring conditions including Alzheimer's disease (AD). Understanding the factors that underlie symptom and age of clinical presentation of dementia in people with DS may provide insights into the mechanisms of sporadic and DS-associated AD (DS-AD). Read More

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http://dx.doi.org/10.1002/alz.12112DOI Listing

The intersection of cerebral fat embolism syndrome and traumatic brain injury: a literature review and case series.

Brain Inj 2020 Jul 16;34(8):1127-1134. Epub 2020 Jun 16.

Department of Physical Medicine and Rehabilitation, Anschutz Medical Campus, University of Colorado , Aurora, Colorado, USA.

Objective: To review the historical, clinical, radiographic, and outcome characteristics of individuals diagnosed with an acquired brain injury (ABI) due to cerebral fat embolism syndrome (CFES) with and without features of traumatic brain injury (TBI).

Methods: A retrospective chart review of individuals with the diagnosis of CFES admitted to an ABI rehabilitation program. Cases were divided into two cohorts 1) individuals with evidence of classic features of CFES alone, and 2) individuals with evidence of CFES in conjunction with features of TBI. Read More

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http://dx.doi.org/10.1080/02699052.2020.1776898DOI Listing

Burnout and Posttraumatic Stress Disorder in the Coronavirus Disease 2019 (COVID-19) Pandemic: Intersection, Impact, and Interventions.

J Am Coll Radiol 2020 Jul 27;17(7):921-926. Epub 2020 May 27.

Program Director, Assistant Radiology Residency, Department of Radiology, Abdominal Imaging, University of Colorado, Aurora, Colorado.

The coronavirus disease 2019 (COVID 2019) pandemic has presented myriad challenges to an underprepared health care system. Health care providers are facing unprecedented acute workplace stress compounded by a high baseline rate of physician burnout. This article discusses the relationship between acute stress disorder, posttraumatic stress disorder, and burnout through a literature review focusing on the mental health impact on health care providers after prior epidemics and natural disasters. Read More

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http://dx.doi.org/10.1016/j.jacr.2020.05.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7250786PMC

The associations of geomagnetic storms, fast solar wind, and stream interaction regions with cardiovascular characteristic in patients with acute coronary syndrome.

Life Sci Space Res (Amst) 2020 May 25;25:1-8. Epub 2020 Jan 25.

Institute of Cardiology, Lithuanian University of Health Sciences, Sukileliu str.17, Kaunas LT-50028, Lithuania. Electronic address:

It is shown the statistical associations between space weather pattern and humans' cardiovascular system. We investigated the association between space weather events and cardiovascular characteristics of 4076 randomly selected patients with acute coronary syndrome (ACS) who were admitted for inpatient treatment in Kaunas city, Lithuania during 2000-2005. We hypothesized that days of the space weather events, 1-3 days after, and the period between two events, named as intersection days (1-3 days after the event, which coincided with 1-3 days before the event), might be associated with patients' cardiovascular characteristics. Read More

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http://dx.doi.org/10.1016/j.lssr.2020.01.002DOI Listing

[Dependency of intraocular pressure on body posture in glaucoma patients : New approaches to pathogenesis and treatment].

Ophthalmologe 2020 Aug;117(8):730-739

Zentrum für Augenheilkunde, Universitätsklinikum Köln, Kerpener Str. 62, 50924, Köln, Deutschland.

Backround: Human intraocular pressure (IOP) depends on the position of the head in relation to the body in space. Physiologically, the IOP increases in a lying position compared to an upright posture. Microgravity in space also appears to cause an increase in intraocular pressure, accompanied by other ophthalmological changes, which are summarized under the term spaceflight associated neuro-ocular syndrome (SANS). Read More

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http://dx.doi.org/10.1007/s00347-020-01113-6DOI Listing

COVID-19, Immuno-oncology and Cardiovascular Disease: Viewpoint from the Intersection.

J Cardiovasc Transl Res 2020 06;13(3):347-348

Cardio-Oncology Program, Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1007/s12265-020-10013-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7197629PMC

Duration for carrying SARS-CoV-2 in COVID-19 patients.

J Infect 2020 07 10;81(1):e78-e79. Epub 2020 Apr 10.

Department of Infectious Diseases, The First Affiliated Hospital of Zhengzhou University, No. 1, Jianshe East Rd, Zhengzhou, 450000 China. Electronic address:

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http://dx.doi.org/10.1016/j.jinf.2020.03.053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7195094PMC

An Update on the Pathophysiology and Treatment of Cardiorenal Syndrome.

Cardiol Res 2020 Apr 10;11(2):76-88. Epub 2020 Mar 10.

Department of Cardiology, Summa Health, Akron, OH, USA.

Cardiorenal syndrome (CRS) encompasses various disorders of the heart and kidneys; dysfunction of one organ leads to acute or chronic dysfunction of the other. It incorporates the intersection of heart-kidney interactions across several mediums, hemodynamically, through the alterations in neurohormonal markers, and increased venous and renal pressure, all of which are hallmarks of its clinical phenotypes. This article explores the epidemiology, pathology, classification and treatment of each type of CRS. Read More

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http://dx.doi.org/10.14740/cr955DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7092771PMC

Advances in cancer cachexia: Intersection between affected organs, mediators, and pharmacological interventions.

Biochim Biophys Acta Rev Cancer 2020 04 25;1873(2):188359. Epub 2020 Mar 25.

Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, USA; Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA. Electronic address:

Advanced cancer patients exhibit cachexia, a condition characterized by a significant reduction in the body weight predominantly from loss of skeletal muscle and adipose tissue. Cachexia is one of the major causes of morbidity and mortality in cancer patients. Decreased food intake and multi-organ energy imbalance in cancer patients worsen the cachexia syndrome. Read More

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http://dx.doi.org/10.1016/j.bbcan.2020.188359DOI Listing
April 2020
7.845 Impact Factor

The Medial Pontine Mid-Tegmentum Syndrome.

J Stroke Cerebrovasc Dis 2020 Jun 24;29(6):104750. Epub 2020 Mar 24.

Department of Neurology, University of California Irvine, Orange, California. Electronic address:

Isolated pontine infarcts are common and are often associated with well-described syndromes that are classified based on their specific clinical presentation and arterial stroke territories. Here we present a case of acute combined diplopia and unilateral lower extremity sensory abnormality. Diffusion-weighted magnetic resonance imaging revealed a punctate area of acute ischemia in the right medial pontine mid-tegmentum. Read More

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2020.104750DOI Listing

Epigenetics of Sepsis.

Crit Care Med 2020 May;48(5):745-756

Keenan and Li Ka Shing Knowledge Institute of Saint Michael's Hospital, Toronto, ON, Canada.

Objectives: Recent evidence from the fields of microbiology and immunology, as well as a small number of human sepsis studies, suggest that epigenetic regulation may play a central role in the pathogenesis of sepsis. The term "epigenetics" refers to regulatory mechanisms that control gene expression but are not related to changes in DNA sequence. These include DNA methylation, histone modifications, and regulation of transcription via non-coding RNAs. Read More

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http://dx.doi.org/10.1097/CCM.0000000000004247DOI Listing

[Prediction modeling with data fusion and prevention strategy analysis for the COVID-19 outbreak].

Zhonghua Liu Xing Bing Xue Za Zhi 2020 Apr;41(4):480-484

School of Public Health, Nanjing Medical University, Nanjing 211166, China.

Since December 2019, the outbreak of COVID-19 in Wuhan has spread rapidly due to population movement during the Spring Festival holidays. Since January 23rd, 2020, the strategies of containment and contact tracing followed by quarantine and isolation has been implemented extensively in mainland China, and the rates of detection and confirmation have been continuously increased, which have effectively suppressed the rapid spread of the epidemic. In the early stage of the outbreak of COVID-19, it is of great practical significance to analyze the transmission risk of the epidemic and evaluate the effectiveness and timeliness of prevention and control strategies by using mathematical models and combining with a small amount of real-time updated multi-source data. Read More

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http://dx.doi.org/10.3760/cma.j.cn112338-20200216-00107DOI Listing

Hand and Wrist Tendinopathies.

Clin Sports Med 2020 Apr;39(2):247-258

Division of Hand and Wrist Surgery, Department of Orthopaedics and Rehabilitation, University of Rochester Medical Center, 601 Elmwood Avenue, Box 665, Rochester, NY 14612, USA. Electronic address:

Tendinopathies in the hand and wrist are common in athletes. This article reviews some of the common hand and wrist conditions, such as trigger digits, first dorsal compartment tendonitis, and extensor carpi ulnaris tendonitis. In addition, it reviews less commonly seen tendon conditions of the flexor carpi radialis and ulnaris, intersection syndrome, and extensor pollicis entrapment conditions. Read More

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http://dx.doi.org/10.1016/j.csm.2019.10.004DOI Listing

The association between etiology of hepatocellular carcinoma and race-ethnicity in Florida.

Liver Int 2020 May 8;40(5):1201-1210. Epub 2020 Mar 8.

Sylvester Comprehensive Cancer Center, University of Miami School of Medicine, Miami, FL, USA.

Background And Aim: The incidence of hepatocellular carcinoma (HCC) has risen considerably in the US since 1980. The main causes include metabolic disorders (NAFLD, diabetes, obesity, metabolic syndrome), alcohol-related disease (ALD) and hepatitis C and B virus infections (HCV, HBV). Etiology-specific HCC incidence rates by detailed race-ethnicity are needed to improve HCC control and prevention efforts. Read More

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http://dx.doi.org/10.1111/liv.14409DOI Listing

Pharmacogenetic investigation of efficacy response to mepolizumab in eosinophilic granulomatosis with polyangiitis.

Rheumatol Int 2020 Aug 3;40(8):1301-1307. Epub 2020 Feb 3.

Genetics, GlaxoSmithKline, Upper Providence, PA, USA.

Treatment of patients with the rare disease eosinophilic granulomatosis with polyangiitis (EGPA) with mepolizumab, a monoclonal antibody to interleukin-5 (IL-5) that reduces blood eosinophil counts, as an add-on therapy to glucocorticoid treatment, results in more accrued weeks in remission, reductions in glucocorticoid use and reductions in relapse rate. However, treatment response varies across a continuum. Therefore, to investigate if large genetic effects could identify responders, the impact of genetic variants on efficacy in EGPA subjects taking mepolizumab and glucocorticoids was assessed in this post hoc study. Read More

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http://dx.doi.org/10.1007/s00296-020-04523-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316687PMC
August 2020
1.627 Impact Factor

Influence of Cardiometabolic Risk Factors on Platelet Function.

Int J Mol Sci 2020 Jan 17;21(2). Epub 2020 Jan 17.

Department of Clinical and Biological Sciences, Turin University, 10043 Orbassano (Turin), Italy.

Platelets are key players in the thrombotic processes. The alterations of platelet function due to the occurrence of metabolic disorders contribute to an increased trend to thrombus formation and arterial occlusion, thus playing a major role in the increased risk of atherothrombotic events in patients with cardiometabolic risk factors. Several lines of evidence strongly correlate metabolic disorders such as obesity, a classical condition of insulin resistance, dyslipidemia, and impaired glucose homeostasis with cardiovascular diseases. Read More

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http://dx.doi.org/10.3390/ijms21020623DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7014042PMC
January 2020

A review of epigenetic contributions 
to post-traumatic stress disorder
.

Dialogues Clin Neurosci 2019 12;21(4):417-428

Partners Healthcare, Boston, Massachusetts, US; McLean Hospital, Belmont, Massachusetts, US; Harvard Medical School, Boston, Massachusetts, US.

Post-traumatic stress disorder (PTSD) is a syndrome which serves as a classic example of psychiatric disorders that result from the intersection of nature and nurture, or gene and environment. By definition, PTSD requires the experience of a traumatic exposure, and yet data suggest that the risk for PTSD in the aftermath of trauma also has a heritable (genetic) component. Thus, PTSD appears to require both a biological (genetic) predisposition that differentially alters how the individual responds to or recovers from trauma exposure. Read More

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http://dx.doi.org/10.31887/DCNS.2019.21.4/kresslerDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6952751PMC
December 2019

Management of intersection syndrome in professional motorcycle rider: a case report.

Acta Biomed 2019 12 23;90(4):556-559. Epub 2019 Dec 23.

1) Clinica Mobile nel Mondo, World Motorbike Championships (MotoGP and WSBK) Medical Division, Parma, Italy; 2) U.O. Clinica Ortopedica Azienda Ospedaliero Universitaria di Parma.

Background And Aim Of The Work: Intersection syndrome is an uncommon and underdiagnosed condition, especially found in sport overuse. This case report describes the treatment of a professional motor biker who presented intense wrist pain and swelling after training sessions.

Methods: The athlete was treated with rest, the use of a wrist splint combined with NSAIDs, physical therapy, including pulsed Nd-YAG laser therapy and exercise, such as stretching and release, massage and eccentric training. Read More

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http://dx.doi.org/10.23750/abm.v90i4.7760DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7233779PMC
December 2019

Circulating miR-206 and Wnt-signaling are associated with cardiovascular complications and a history of preeclampsia in women.

Clin Sci (Lond) 2020 01;134(2):87-101

Institute of Cardiovascular and Medical Sciences, University of Glasgow, Scotland, U.K.

Women with a history of preeclampsia (PE) have increased risk of cardiovascular disease (CVD) later in life. However, the molecular determinants underlying this risk remain unclear. We sought to understand how circulating miRNA levels are affected by prior PE, and related to biological pathways underpinning cardiovascular disease. Read More

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http://dx.doi.org/10.1042/CS20190920DOI Listing
January 2020
5.598 Impact Factor

Pathogenetic approach to the treatment of functional disorders of the gastrointestinal tract and their intersection: results of the Russian observation retrospective program COMFORT.

BMC Gastroenterol 2019 Dec 31;20(1). Epub 2019 Dec 31.

The Institute of General Pathology and Pathophysiology, 8, Baltiyskaya St, Moscow, Russian Federation, 125315.

Background: The aim of this study was to investigate the efficacy and safety of the novel complex drug, consisting of released-active form of antibodies to S-100 protein, tumor necrosis factor-α and histamine, (Kolofort) under outpatient conditions in patients with functional dyspepsia (FD), irritable bowel syndrome (IBS), and FD-IBS overlap.

Methods: The subjects of the observational noninterventional retrospective program were the data of 14,362 outpatient records of patients with diagnosed FD, IBS, and/or overlap, who were observed by gastroenterologists from November 01, 2017, through March 30, 2018, who received the drug Kolofort in monotherapy for 12 weeks, 2 tablets twice a day. To assess the presence and severity of symptoms of functional gastrointestinal disorders (FGID), the "7*7" questionnaire developed by a working group from the Russian Gastroenterological Association was used. Read More

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http://dx.doi.org/10.1186/s12876-019-1143-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6938622PMC
December 2019

Relationship between elderly stroke patient caregivers scale and nursing diagnoses.

Rev Bras Enferm 2019 Nov;72(suppl 2):251-258

Universidade Federal do Rio Grande do Sul. Porto Alegre, Rio Grande do Sul, Brazil.

Objective: To describe relationships between the ECPICID-AVC scale factors and the NANDA-I domains, classes, and Nursing Diagnoses (NDs).

Method: Cross-mapping study between the NANDA-I taxonomy and ECPICID-AVC scale was constructed based on the eight ECPICID-AVC scale factors and the 13 NANDA-I domains. A descriptive analysis was performed to present the mapped elements. Read More

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http://dx.doi.org/10.1590/0034-7167-2018-0787DOI Listing
November 2019

PPARα-targeted mitochondrial bioenergetics mediate repair of intestinal barriers at the host-microbe intersection during SIV infection.

Proc Natl Acad Sci U S A 2019 12 18;116(49):24819-24829. Epub 2019 Nov 18.

Department of Medical Microbiology & Immunology, University of California Davis School of Medicine, Davis, CA 95616;

Chronic gut inflammatory diseases are associated with disruption of intestinal epithelial barriers and impaired mucosal immunity. HIV-1 (HIV) causes depletion of mucosal CD4 T cells early in infection and disruption of gut epithelium, resulting in chronic inflammation and immunodeficiency. Although antiretroviral therapy (ART) is effective in suppressing viral replication, it is incapable of restoring the "leaky gut," which poses an impediment for HIV cure efforts. Read More

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http://dx.doi.org/10.1073/pnas.1908977116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6900595PMC
December 2019

Premature birth, homeostatic plasticity and respiratory consequences of inflammation.

Respir Physiol Neurobiol 2020 03 13;274:103337. Epub 2019 Nov 13.

Department of Biology, School of Computer, Mathematics and Natural Sciences (SCMNS), Morgan State University, Baltimore, MD, 21251, United States.

Infants who are born premature can have persistent apnea beyond term gestation, reemergence of apnea associated with inflammation during infancy, increased risk of sudden unexplained death, and sleep disorder breathing during infancy and childhood. The autonomic nervous system, particularly the central neural networks that control breathing and peripheral and central chemoreceptors and mechanoreceptors that modulate the activity of the central respiratory network, are rapidly developing during the last trimester (22-37 weeks gestation) of fetal life. With advances in neonatology, in well-resourced, developed countries, infants born as young as 23 weeks gestation can survive. Read More

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http://dx.doi.org/10.1016/j.resp.2019.103337DOI Listing

Arrhythmias in Adults With Congenital Heart Disease: What the Practicing Cardiologist Needs to Know.

Authors:
Paul Khairy

Can J Cardiol 2019 Dec 16;35(12):1698-1707. Epub 2019 Jul 16.

Electrophysiology Service and Adult Congenital Heart Disease Center, Montreal Heart Institute, Université de Montréal, Montreal, Québec, Canada. Electronic address:

The expanding population of adults with congenital heart disease (CHD) combined with the pervasiveness of arrhythmias has resulted in the rapid growth of a dedicated sector of cardiology at the intersection between 2 subspecialties: electrophysiology and adult CHD. Herein, practical considerations are offered regarding urgent referral for catheter ablation of atrial arrhythmias, anticoagulation, and primary prevention implantable cardioverter-defibrillators (ICDs). Patients with Ebstein anomaly and ventricular pre-excitation should be referred promptly due to the high prevalence of multiple accessory pathways and increased incidence of atrial tachyarrhythmias, which may be poorly tolerated. Read More

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http://dx.doi.org/10.1016/j.cjca.2019.07.009DOI Listing
December 2019

Spontaneous Bacterial Peritonitis in Cardiac Ascites: A Rare but Deadly Occurrence.

Am J Case Rep 2019 Oct 1;20:1446-1448. Epub 2019 Oct 1.

Department of Medicine, Boston Medical Center, Boston University School of Medicine, Boston, MA, USA.

BACKGROUND Spontaneous bacterial peritonitis is frequently described in cirrhotic patients who develop infected ascitic fluid. However, ascites can be cardiac in origin. The phenomenon of spontaneous bacterial peritonitis in cardiac ascites is an extremely rare but deadly occurrence. Read More

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http://dx.doi.org/10.12659/AJCR.915944DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6788488PMC
October 2019
5 Reads

Master knot of Henry revisited: a radiologist's perspective on MRI.

Clin Radiol 2019 Dec 25;74(12):972.e1-972.e8. Epub 2019 Sep 25.

Department of Musculoskeletal Radiology, Royal Orthopaedic Hospital, Birmingham B31 2AP, UK.

The master knot of Henry refers to a narrow space located between the anatomical crossover of the flexor hallucis longus and flexor digitorum longus tendons. This small space is prone to "intersection syndrome," as a result of tendinosis, tenosynovitis, and tears of the aforementioned tendons at the knot of Henry. The aim of this educational review is to detail the anatomy of the knot of Henry, including common variations in the tendon position and orientation. Read More

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http://dx.doi.org/10.1016/j.crad.2019.08.011DOI Listing
December 2019
1 Read

Updated Review and Treatment Recommendations on Paraneoplastic Neurologic Syndromes and Chronic Pain.

Pain Physician 2019 09;22(5):433-445

Department of Anesthesiology and Pain Medicine, University of California San Diego Health Sciences, La Jolla, CA; VA San Diego Healthcare System, San Diego, CA.

Background: This comprehensive review of pain in paraneoplastic neurological syndromes focuses on current mechanisms that lead to pain, including autoimmune processes as well as the systemic secretion of factors that sensitize nociceptive nerves. Systemic secretion of functional molecules is a well-recognized phenomenon in endocrine paraneoplastic syndromes; however, cancer pain research has predominantly focused on cytokine-nerve interactions in the tumor microenvironment, and few groups have applied the molecular mechanisms of local pain to study widespread neuropathic pain resulting from systemic secretion. We present a novel perspective in the field of pain research by converging data from clinical oncology with recent molecular pain research on cytokine-mediated sensitization of nociceptive nerves. Read More

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September 2019
1 Read

[Multidisciplinary approach in urology. Clinical aspects].

Urologiia 2019 Sep(4 ()):28-35

FGAOU VO I.M. Sechenov First Moscow State Medical University of Minzdrav of Russia, Moscow, Russia.

A solving diagnostic and therapeutic problems in patients with various urologic diseases often requires a cooperation between different specialists which emphasizes the interdisciplinarity of our discipline. A number of clinical manifestations and diseases that urologists have to deal with and in which they definitely need a timely assistance from other specialists are described in the article. Determining the connecting links in the work of different specialists, we tried to recall the main " intersection points" and draw attention to the necessary cooperation. Read More

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September 2019
3 Reads

The disconnect between individual-level and population-level HIV prevention benefits of antiretroviral treatment.

Lancet HIV 2019 09 19;6(9):e632-e638. Epub 2019 Jul 19.

St Michael's Hospital, Li Ka Shing Knowledge Institute, and Department of Medicine, Division of Infectious Disease, University of Toronto, Toronto, Canada.

In 2019, the HIV pandemic is growing and soon over 40 million people will be living with HIV. Effective population-based approaches to decrease HIV incidence are as relevant as ever given modest reductions observed over the past decade. Treatment as prevention is often heralded as the path to improve HIV outcomes and to reduce HIV incidence. Read More

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http://dx.doi.org/10.1016/S2352-3018(19)30226-7DOI Listing
September 2019
1 Read

[Clinical value of V-shaped concealed incision in parotid benign tumors].

Authors:
J Su P Li X B Ji J H Xie

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2019 Jul;33(7):615-618

Department of Otorhinolaryngology Head and Neck Surgery, Guangzhou First People's Hospital, Guangzhou, 510180,China.

The aim of this study is to explore the clinical value of V-shaped concealed incision in parotid benign tumors surgery.Thirty-two patients with benign parotid tumors who were hospitalized from January 2016 to December 2017 were selected. All patients were treated with a V-shaped incision approach, starting from the anterior dermatoglyph of the tragus,extending downward to the earlobe and backward to the posterior earlobe, which formed an intersection point of the earlobe for parotid benign tumors,superficial lobectomy and facial nerve dissection. Read More

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http://dx.doi.org/10.13201/j.issn.1001-1781.2019.07.010DOI Listing
July 2019
4 Reads

Castleman Disease Presenting with Pseudotumour Cerebri and Myasthenia Gravis: A Case Report and Literature Review.

Neuroophthalmology 2019 Jun 26;43(3):185-191. Epub 2018 Jun 26.

Department of Neurology, University Health Care Center.

Castleman disease (CD) is a rare lymphoproliferative disorder that may present with various autoimmune, inflammatory, or neurologic syndromes. This is a case of a 21-year-old woman who presented with signs and symptoms of pseudotumour cerebri (PTC) who subsequently developed myasthenia gravis (MG), and was incidentally found to have a large mass in the posterior mediastinum. Upon resection, the mass was classified as unicentric CD involved with follicular dendritic cell sarcoma. Read More

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http://dx.doi.org/10.1080/01658107.2018.1484932DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6619924PMC
June 2019
6 Reads

Intersection syndrome: an acute surgical disease in elite rowers.

BMJ Open Sport Exerc Med 2019 7;5(1):e000535. Epub 2019 Jun 7.

Victorian Institute of Sport, Melbourne, Victoria, Australia.

Objective: Intersection syndrome is a relatively common condition in elite rowers and continuing conjecture over its pathology and best management often includes prolonged withdrawal from training and changes to the technique that may affect rowing outcomes.

Methods: We reviewed a case series in a national rowing squad and the effect on time loss produced by the condition. We reviewed the pathophysiology. Read More

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http://dx.doi.org/10.1136/bmjsem-2019-000535DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6563899PMC
June 2019
6 Reads

An Overview and Proposed Research Framework for Studying Co-Occurring Mental- and Physical-Health Dysfunction.

Perspect Psychol Sci 2019 07 7;14(4):633-645. Epub 2019 Jun 7.

1 Department of Psychology and Neuroscience, University of Colorado Boulder.

Mental- and physical-health conditions co-occur at a rate much higher than chance. Of patients who have a mental-health condition, more than half also have a physical disease, and these cases are associated with increased human suffering and societal cost. Comorbidity research to date has focused on co-occurring mental- and physical-health disorders separately, and relatively little research has examined the co-occurrence of mental- and physical-health dysfunction. Read More

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http://dx.doi.org/10.1177/1745691619827010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6778441PMC
July 2019
7 Reads

Evaluation of the pressure on the dorsal surface of the distal radius using a cadaveric and computational model: clinical considerations in intersection syndrome and Colles' fracture.

Anat Sci Int 2020 Jan 4;95(1):38-46. Epub 2019 Jun 4.

Department of Anatomy, Aichi Medical University, 1-1 Yazakokarimata, Nagakute, 480-1195, Aichi, Japan.

The fibers of the abductor pollicis longus (APL) and extensor pollicis brevis (EPB) muscles intersect the distal radius. This anatomical structure puts pressure on the dorsal surface of the distal radius when various wrist positions are adopted. An increase in this pressure is associated with the risk of intersection syndrome and with immobilization after Colles' fracture. Read More

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http://dx.doi.org/10.1007/s12565-019-00491-5DOI Listing
January 2020
12 Reads

Prediabetes and Risk for Cardiac Death Among Patients With Coronary Artery Disease: The ARTEMIS Study.

Diabetes Care 2019 07 10;42(7):1319-1325. Epub 2019 May 10.

Research Unit of Internal Medicine, Medical Research Center Oulu, University of Oulu and Oulu University Hospital, Oulu, Finland.

Objective: To compare cardiac mortality in patients with CAD and prediabetes with that in CAD patients with normal glycemic status and type 2 diabetes.

Research Design And Methods: The Innovation to Reduce Cardiovascular Complications of Diabetes at the Intersection (ARTEMIS) study included patients with CAD after revascularization (79%), optimal medical therapy, or both. Patients had type 2 diabetes ( = 834), impaired glucose tolerance (IGT; = 314), impaired fasting glucose (IFG; = 103), or normal glycemic status ( = 697) as defined on the basis of the results of an oral glucose tolerance test. Read More

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http://care.diabetesjournals.org/lookup/doi/10.2337/dc18-254
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http://dx.doi.org/10.2337/dc18-2549DOI Listing
July 2019
21 Reads

Infant With Trisomy 18 and Hypoplastic Left Heart Syndrome.

Pediatrics 2019 05 4;143(5). Epub 2019 Apr 4.

Children's Mercy Bioethics Center, Children's Mercy Hospital, Kansas City, Missouri.

We present a case in which a fetal diagnosis of complex congenital heart disease and trisomy 18 led to a series of decisions for an infant who was critically ill. The parents wanted everything done. The surgeons believed that surgery would be futile. Read More

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http://dx.doi.org/10.1542/peds.2018-3779DOI Listing
May 2019
22 Reads

Frontal-subcortical behaviors during Alzheimer's disease in individuals with Down syndrome.

Neurobiol Aging 2019 06 11;78:186-194. Epub 2019 Mar 11.

Obsessive-Compulsive Spectrum Disorders Program, PROTOC, Department and Institute of Psychiatry, University of São Paulo School of Medicine, FMUSP, São Paulo, Brazil.

There is evidence that frontal-subcortical circuits play an important role in the initial presentation of dementia in Down syndrome (DS), including changes in behavior, a decline in working memory and executive dysfunction. We evaluated 92 individuals with DS (≥30 years of age), divided into 3 groups by diagnosis-stable cognition, prodromal dementia, and Alzheimer's disease. Each individual was evaluated with an executive protocol developed for people with intellectual disabilities and was rated for behaviors related to frontal lobe dysfunction (disinhibition, executive dysfunction, and apathy) by an informant using the Frontal Systems Behavior Scale. Read More

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http://dx.doi.org/10.1016/j.neurobiolaging.2019.02.028DOI Listing
June 2019
28 Reads

Activity-Dependent Remodeling of Olfactory Sensory Neuron Brain Innervation during an Early-Life Critical Period.

J Neurosci 2019 04 12;39(16):2995-3012. Epub 2019 Feb 12.

Vanderbilt Brain Institute,

Critical periods are windows of development when the environment has a pronounced effect on brain circuitry. Models of neurodevelopmental disorders, including autism spectrum disorders, intellectual disabilities, and schizophrenia, are linked to disruption of critical period remodeling. Critical periods open with the onset of sensory experience; however, it remains unclear exactly how sensory input modifies brain circuits. Read More

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http://dx.doi.org/10.1523/JNEUROSCI.2223-18.2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468095PMC
April 2019
10 Reads

[Expression and Function of miR-99a-5p in Bone Marrow of Patients with MDS].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2019 Feb;27(1):134-140

Department of Hematology, The First Affliated Hospital, Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China.E-mail:

Objective: To detect the expression of miR-99a-5p in myelodysplastic syndrome (MDS), to predict the target genes and to analyze its function by using bioinformatics.

Methods: The expression levels of bone marrow miR-99a-5p in MDS patients were detected by qRT-PCR, and the correlation of miR-99a-5p expression with clinical pathological characteristics, percentage of marrow blasts , chromosome karyotype and peripheral blood hemogram were analyzed. The target genes of miR-99a-5p were predicted by Targetscan, Miranda and Microcosm, and the intersection of the predicted results of 3 softwares was used as a potential target gene for miR-99a-5p. Read More

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http://dx.doi.org/10.7534/j.issn.1009-2137.2019.01.022DOI Listing
February 2019
7 Reads

Towards a better diagnosis and treatment of Rett syndrome: a model synaptic disorder.

Brain 2019 02;142(2):239-248

Department of Human Genetics, Emory University School of Medicine, Atlanta GA, USA.

With the recent 50th anniversary of the first publication on Rett syndrome, and the almost 20 years since the first report on the link between Rett syndrome and MECP2 mutations, it is important to reflect on the tremendous advances in our understanding and their implications for the diagnosis and treatment of this neurodevelopmental disorder. Rett syndrome features an interesting challenge for biologists and clinicians, as the disorder lies at the intersection of molecular mechanisms of epigenetic regulation and neurophysiological alterations in synapses and circuits that together contribute to severe pathophysiological endophenotypes. Genetic, clinical, and neurobiological evidences support the notion that Rett syndrome is primarily a synaptic disorder, and a disease model for both intellectual disability and autism spectrum disorder. Read More

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https://academic.oup.com/brain/advance-article/doi/10.1093/b
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http://dx.doi.org/10.1093/brain/awy323DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6933507PMC
February 2019
32 Reads

Best Practices in Fragile X Syndrome Treatment Development.

Brain Sci 2018 Dec 15;8(12). Epub 2018 Dec 15.

Departments of Pediatrics, Neurological Sciences, Biochemistry, Rush University Medical Center, Chicago, IL 60612, USA.

Preclinical studies using animal models of fragile X syndrome have yielded several agents that rescue a wide variety of phenotypes. However, translation of these treatments to humans with the disorder has not yet been successful, shedding light on a variety of limitations with both animal models and human trial design. As members of the Clinical Trials Committee of the National Fragile X Foundation, we have discussed a variety of recommendations at the level of preclinical development, transition from preclinical to human projects, family involvement, and multi-site trial planning. Read More

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http://dx.doi.org/10.3390/brainsci8120224DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315698PMC
December 2018
10 Reads

Functional significance of channelopathy gene variants in unexplained death.

Forensic Sci Med Pathol 2019 Sep 13;15(3):437-444. Epub 2018 Dec 13.

Pediatrics, NYU School of Medicine, 450 E 29th Street, ACLS 824, New York, NY, 10016, USA.

Determining the cause of unexplained death in all age groups, including infants, is a priority in forensic medicine. The triple risk model proposed for sudden infant death syndrome involves the intersection of three risks: (1) a critical developmental period in homeostatic control (2), exogenous stressors, and (3) a vulnerable infant. Even though sex and age factor into some forms of inherited arrhythmogenic deaths in young individuals and adults, more appropriate a dual-risk disease model for adults involves exogenous stressors and a vulnerable individual. Read More

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http://link.springer.com/10.1007/s12024-018-0063-y
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http://dx.doi.org/10.1007/s12024-018-0063-yDOI Listing
September 2019
35 Reads

Polygenic risk score identifies associations between sleep duration and diseases determined from an electronic medical record biobank.

Sleep 2019 03;42(3)

Center for Genomic Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA.

Study Objectives: We aimed to detect cross-sectional phenotype and polygenic risk score (PRS) associations between sleep duration and prevalent diseases using the Partners Biobank, a hospital-based cohort study linking electronic medical records (EMR) with genetic information.

Methods: Disease prevalence was determined from EMR, and sleep duration was self-reported. A PRS for sleep duration was derived using 78 previously associated SNPs from genome-wide association studies (GWAS) for self-reported sleep duration. Read More

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http://dx.doi.org/10.1093/sleep/zsy247DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424085PMC
March 2019
12 Reads