397 results match your criteria Intersection Syndrome

The experiences of the caring dyad: (Un)articulated realities of living with cardiometabolic risk, metabolic syndrome and related diseases in severe mental illness.

Health Expect 2021 Aug 2. Epub 2021 Aug 2.

School of Humanities and Social Sciences, Aston University, Birmingham, UK.

Background: Informal carers play an important role in the care of patients with mental illness. Little is known of the relationship experience of the patient and their informal carer (caring dyad) as the context for the intersection between physical and mental health.

Aim: This study aimed to explore the impact of comorbid cardiometabolic risk (CMR), metabolic syndrome (MetS) and related diseases and severe mental illness (SMI) on the caring dyad. Read More

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STING1 in sepsis: Mechanisms, functions, and implications.

Chin J Traumatol 2021 Jul 19. Epub 2021 Jul 19.

Department of Surgery, UT Southwestern Medical Center, Dallas, TX, 75390, USA. Electronic address:

Sepsis is a life-threatening clinical syndrome and one of the most challenging health problems in the world. Pathologically, sepsis and septic shock are caused by a dysregulated host immune response to infection, which can eventually lead to multiple organ failure and even death. As an adaptor transporter between the endoplasmic reticulum and Golgi apparatus, stimulator of interferon response cGAMP interactor 1 (STING1, also known as STING or TMEM173) has been found to play a vital role at the intersection of innate immunity, inflammation, autophagy, and cell death in response to invading microbial pathogens or endogenous host damage. Read More

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Exploiting the molecular basis of age and gender differences in outcomes of SARS-CoV-2 infections.

Comput Struct Biotechnol J 2021 10;19:4092-4100. Epub 2021 Jul 10.

University of Catanzaro, Department of Medical and Surgical Sciences, Italy.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (coronavirus disease, 2019; COVID-19) is associated with adverse outcomes in patients. It has been observed that lethality seems to be related to the age of patients. While ageing has been extensively demonstrated to be accompanied by some modifications at the gene expression level, a possible link with COVID-19 manifestation still need to be investigated at the molecular level. Read More

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[Study on mechanism of Bushen Culuan Formula in treatment of polycystic ovary syndrome based on network pharmacology and molecular docking].

Zhongguo Zhong Yao Za Zhi 2021 Jun;46(11):2650-2659

Xiyuan Hospital, China Academy of Chinese Medical Sciences Beijing 100091, China.

This study used network pharmacology and molecular docking to study the mechanism of Bushen Culuan Formula in the treatment of infertility caused by polycystic ovary syndrome(PCOS). The active ingredients and potential drug targets of Bushen Cu-luan Decoction were obtained by searching the Traditional Chinese Medicine System Pharmacology(TCMSP) database, and the targets of PCOS by searching GeneCards. After the drug targets and disease targets were corrected by Uniprot, the intersection genes were obtained. Read More

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Rethinking the management of immune checkpoint inhibitor-related adrenal insufficiency in cancer patients during the COVID-19 pandemic.

Endocrinol Diabetes Metab 2021 07 8;4(3):e00246. Epub 2021 Mar 8.

Division of Endocrinology and Molecular Medicine Medical College of Wisconsin Milwaukee Wisconsin USA.

Introduction: The coronavirus disease 2019 (COVID-19) is currently a major pandemic challenge, and cancer patients are at a heightened risk of severity and mortality from this infection. In recent years, immune checkpoint inhibitor (ICI) use to treat multiple cancers has increased in oncology, but equally has raised the question of whether ICI therapy and its side-effects is harmful or beneficial during this pandemic.

Methods: A combination of published literature in PubMed between January 2010 and December 2020, recommended guidelines in non-cancer patients, and clinical experience was utilized to outline recommendations on glucocorticoid timing and dosing regimens in ICI-treated patients presenting with AI during this COVID-19 pandemic. Read More

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Integrative analysis of key candidate genes and signaling pathways in acute coronary syndrome related to obstructive sleep apnea by bioinformatics.

Sci Rep 2021 Jul 8;11(1):14153. Epub 2021 Jul 8.

Department of Cardiology, Jiaxing Second Hospital, Jiaxing, China.

Although obstructive sleep apnea (OSA) has been clinically reported to be associated with acute coronary syndrome (ACS), the pathogenesis between the two is unclear. Herein, we analyzed and screened out the prospective molecular marker. To explore the candidate genes, as well as signaling cascades involved in ACS related to OSA, we extracted the integrated differentially expressed genes (DEGs) from the intersection of genes from the Gene Expression Omnibus (GEO) cohorts and text mining, followed by enrichment of the matching cell signal cascade through DAVID analysis. Read More

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The -Mediated Xq28 Duplication Syndrome: An Intersection between Neurodevelopment, Immunology, and Cancer.

Genes (Basel) 2021 Jun 4;12(6). Epub 2021 Jun 4.

Department of Clinical Sciences, College of Medicine, University of Sharjah, Sharjah P. O. Box 27272, United Arab Emirates.

The -mediated Xq28 duplication syndrome is a rare X-linked intellectual disability syndrome (XLIDS) arising from a duplication of the segment between intron 22 homologous regions 1 and 2, on the q28 subregion of the X chromosome. The main clinical features of the syndrome include intellectual disability, neurobehavioral abnormalities, and dysmorphic facial features. Due to the X-linked nature of the syndrome, affected males exhibit more severe phenotypes compared with heterozygous females. Read More

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Identifiability and Estimation Under the Test-negative Design With Population Controls With the Goal of Identifying Risk and Preventive Factors for SARS-CoV-2 Infection.

Epidemiology 2021 Sep;32(5):690-697

Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montréal, Québec, Canada.

Owing to the rapidly evolving coronavirus disease 2019 (COVID-19) pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus, quick public health investigations of the relationships between behaviors and infection risk are essential. Recently the test-negative design (TND) was proposed to recruit and survey participants who are symptomatic and being tested for SARS-CoV-2 infection with the goal of evaluating associations between the survey responses (including behaviors and environment) and testing positive on the test. It was also proposed to recruit additional controls who are part of the general population as a baseline comparison group to evaluate risk factors specific to SARS-CoV-2 infection. Read More

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September 2021

Gene signatures and potential therapeutic targets of Middle East respiratory syndrome coronavirus (MERS-CoV)-infected human lung adenocarcinoma epithelial cells.

J Microbiol Immunol Infect 2021 Mar 26. Epub 2021 Mar 26.

Department of Biochemistry and Molecular Biology, National Cheng Kung University, Tainan 70101, Taiwan; Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan. Electronic address:

Background: Pathogenic coronaviruses include Middle East respiratory syndrome coronavirus (MERS-CoV), severe acute respiratory syndrome coronavirus (SARS-CoV), and SARS-CoV-2. These viruses have induced outbreaks worldwide, and there are currently no effective medications against them. Therefore, there is an urgent need to develop potential drugs against coronaviruses. Read More

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Successful Ablation of an Epicardial Accessory Pathway via the Subxiphoid Approach in a Child.

Mohammad Dalili

Indian Pacing Electrophysiol J 2021 Jun 16. Epub 2021 Jun 16.

Department of Pediatric Cardiology, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Shaheed Rajaei Cardiovascular Medical and Research Center, Valiasr Ave, Niayesh Intersection, PO Code: 1995614331, Tehran, Iran. Electronic address:

Data is scarce regarding epicardial ablation in children. I herewith present a case of successful epicardial ablation in a child with previous unsuccessful attempts at endocardial ablation. This report could be used to guide further such attempts. Read More

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Implications of Ehlers-Danlos Syndrome in a Patient With Mayer-Rokitansky-Küster-Hauser Syndrome.

J Pediatr Adolesc Gynecol 2021 Jun 11. Epub 2021 Jun 11.

Division of Pediatric and Adolescent Gynecology, Baylor College of Medicine, Houston, Texas.

Background: Ehlers-Danlos syndromes (EDS) are a heterogenous group of connective tissue disorders characterized by defective collagen production. Patients with EDS have lax and fragile connective tissue in their joints, skin, blood vessels, and hollow organs. This can lead to, among other complications, joint hypermobility, aneurysms, organ prolapse, and musculoskeletal chronic pain. Read More

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Forty Years of HIV: The Intersection of Laws, Stigma, and Sexual Behavior and Identity.

David W Purcell

Am J Public Health 2021 Jun 10:e1-e3. Epub 2021 Jun 10.

David W. Purcell is retired from the Division of HIV/AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, GA.

Forty years after the Centers for Disease Control and Prevention's (CDC's) June 1981 about five gay men with a syndrome that came to be called AIDS, both the impact of HIV and the legal landscape in the United States for the most affected population have changed dramatically. Laws, policies, and how they are enforced reflect the values and prejudices of society, and laws can help or hinder public health efforts, regardless of intent. From the outset, HIV aroused widespread fear and new stigmatizing laws and policies, and the crisis revealed injustices in existing laws that compounded stigma and health disparities among the most affected groups. Read More

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Expanding sexual and gender minority research in movement disorders: More than awareness and acceptance.

Parkinsonism Relat Disord 2021 Jun 24;87:162-165. Epub 2021 May 24.

Department of Neurology, University of Massachusetts Memorial Medical Center, Worcester, MA, USA. Electronic address:

Culturally competent and inclusive care is slowly becoming the standard throughout healthcare institutions. Awareness, acceptance, and inclusion of the sexual and gender minority (SGM) groups in medicine and neurology are progressing. Research in SGM health, although increasing, remains remarkably scant in parkinsonism and other movement disorders, a community whose patient population is on the rise. Read More

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Urinary vitamin D-binding protein as a marker of ovarian reserve.

Reprod Biol Endocrinol 2021 Jun 1;19(1):80. Epub 2021 Jun 1.

Reproductive Medicine Center, Department of Gynecology and Obstetrics, The Second Affiliated Hospital, Chongqing Medical University, 76 Linjiang Road, Chongqing, 400010, China.

Background: Ovarian reserve reflects the quality and quantity of available oocytes and has become an indispensable measure for the better understanding of reproductive potential. Proteomic approaches are especially helpful in discerning differential protein expression patterns associated with normal and diseased states and, thus, proteomic analyses are increasingly used to identify clinically useful biomarkers. The aim of this study was to investigate proteins secreted in the urine of patients with different ovarian reserve by proteomic techniques to identify potential markers for assessing ovarian reserve. Read More

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HIV-related stigma in the UK then and now: to what extent are we on track to eliminate stigma? A qualitative investigation.

BMC Public Health 2021 05 30;21(1):1022. Epub 2021 May 30.

University of Westminster, London, UK.

Background: The introduction of effective antiretroviral treatment in the late 1990s led to the perception that HIV was a chronic but manageable condition. Nevertheless, stigma remains one of the major hurdles for people living with HIV (PLWH) to accessing healthcare and biomedical preventions. Thus, Fast Track Cities has set a target of zero HIV discrimination by 2030 as part of its strategy to end HIV transmission. Read More

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The Intersection of Parkinson's Disease, Viral Infections, and COVID-19.

Mol Neurobiol 2021 May 25. Epub 2021 May 25.

Department of Biological Sciences, St. John's University, New York, NY, 11439, USA.

The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the causative agent of human COVID-19, not only causes flu-like symptoms and gut microbiome complications but a large number of infected individuals also experience a host of neurological symptoms including loss of smell and taste, seizures, difficulty concentrating, decreased alertness, and brain inflammation. Although SARS-CoV-2 infections are not more prevalent in Parkinson's disease patients, a higher mortality rate has been reported not only associated with older age and longer disease duration, but also through several mechanisms, such as interactions with the brain dopaminergic system and through systemic inflammatory responses. Indeed, a number of the neurological symptoms seen in COVID-19 patients, as well as the alterations in the gut microbiome, are also prevalent in patients with Parkinson's disease. Read More

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The effects of substance use on severe acute respiratory syndrome coronavirus infection risks and outcomes.

Curr Opin Psychiatry 2021 07;34(4):386-392

Departments of Internal Medicine, Pediatrics, and Population and Quantitative Health Sciences, and the Center for Clinical Informatics Research and Education, Case Western Reserve University/The MetroHealth System, Cleveland, Ohio, USA.

Purpose Of Review: Severe acute respiratory syndrome coronavirus (SARS-CoV2) infection rates are currently occurring at alarmingly accelerated rates. There is also a long-standing and concurrent rise in the prevalence and severity of substance use disorders (SUD). Therefore, the intersection between these two conditions needs to be carefully considered to ensure a more effective delivery of healthcare. Read More

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The intersection of COVID-19 and cancer: signaling pathways and treatment implications.

Mol Cancer 2021 05 17;20(1):76. Epub 2021 May 17.

Institutes of Biology and Medical Sciences, Soochow University, Suzhou, 215123, China.

The outbreak of the novel coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has emerged as a serious public health concern. Patients with cancer have been disproportionately affected by this pandemic. Increasing evidence has documented that patients with malignancies are highly susceptible to severe infections and mortality from COVID-19. Read More

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Patient Experiences of Health Care Providers in Premenstrual Dysphoric Disorder: Examining the Role of Provider Specialty.

J Womens Health (Larchmt) 2021 Apr 1. Epub 2021 Apr 1.

Department of Psychiatry, University of Illinois at Chicago, Chicago, Illinois, USA.

Premenstrual dysphoric disorder (PMDD) is a severe mood disorder that affects ∼5% of menstruating individuals. Although symptoms are limited to the luteal phase of the menstrual cycle, PMDD causes significant distress and impairment across a range of activities. PMDD is under-recognized by health care providers, can be difficult to diagnose, and lies at the intersection of gynecology and psychiatry. Read More

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Salvaging the endothelium in acute respiratory distress syndrome: a druggable intersection between TLR4 and NAD signalling.

Eur Respir J 2021 05 6;57(5). Epub 2021 May 6.

Dept of Physiology and Cell Biology, University of South Alabama, Mobile, AL, USA.

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Based on Network Pharmacology and RNA Sequencing Techniques to Explore the Molecular Mechanism of Huatan Jiangzhuo Decoction for Treating Hyperlipidemia.

Evid Based Complement Alternat Med 2021 9;2021:9863714. Epub 2021 Apr 9.

Laboratory of TCM Syndrome Essence and Objectification, School of Basic Medical Sciences, Guangzhou University of Chinese Medicine, Guangzhou 510006, China.

Background: Hyperlipidemia, due to the practice of unhealthy lifestyles of modern people, has been a disturbance to a large portion of population worldwide. Recently, several scholars have turned their attention to Chinese medicine (CM) to seek out a lipid-lowering approach with high efficiency and low toxicity. This study aimed to explore the mechanism of Huatan Jiangzhuo decoction (HTJZD, a prescription of CM) in the treatment of hyperlipidemia and to determine the major regulation pathways and potential key targets involved in the treatment process. Read More

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Guillain-Barre Syndrome in a Patient With Asymptomatic Coronavirus Disease 2019 Infection and Major Depressive Disorder.

Cureus 2021 Mar 28;13(3):e14161. Epub 2021 Mar 28.

Psychiatry, St. Luke's University Hospital Network, Bethlehem, USA.

Coronavirus disease 2019 (COVID-19) has had a devastating effect on all aspects of society, including the economy, healthcare, and educational institutions. One underrecognized effect of the pandemic is the decline of mental health in our communities. Studies have shown that pandemic-related stress is associated with increased depression and anxiety. Read More

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Neurologic Emergencies during the Coronavirus Disease 2019 Pandemic.

Neurol Clin 2021 05 26;39(2):671-687. Epub 2021 Mar 26.

Department of Neurology, Boston University School of Medicine, 72 East Concord Street, Suite C3, Boston, MA 02118, USA; Department of Neurosurgery, Boston University School of Medicine, 725 Albany St, Suite 7C, Boston, MA 02118, USA; Department of Medicine (Infectious Diseases), Boston University School of Medicine, 801 Massachusetts Avenue, Crosstown, 2nd floor, Boston MA 02118, USA.

Although minor neurologic complications of coronavirus disease 2019 are common, life-threatening neurologic emergencies are rare. Acute ischemic stroke, intracerebral hemorrhage, venous sinus thrombosis, seizures, and posterior reversible encephalopathy syndrome have been described. Hospitals have seen significant changes in the volume of patients presenting with neurologic emergencies. Read More

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Paroxysmal Genetic Movement Disorders and Epilepsy.

Front Neurol 2021 23;12:648031. Epub 2021 Mar 23.

Department of Neurology, Universidade Estadual de Campinas (UNICAMP), São Paulo, Brazil.

Paroxysmal movement disorders include paroxysmal kinesigenic dyskinesia, paroxysmal non-kinesigenic dyskinesia, paroxysmal exercise-induced dyskinesia, and episodic ataxias. In recent years, there has been renewed interest and recognition of these disorders and their intersection with epilepsy, at the molecular and pathophysiological levels. In this review, we discuss how these distinct phenotypes were constructed from a historical perspective and discuss how they are currently coalescing into established genetic etiologies with extensive pleiotropy, emphasizing clinical phenotyping important for diagnosis and for interpreting results from genetic testing. Read More

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Nexus between COVID-19 and periodontal disease.

J Int Med Res 2021 Mar;49(3):3000605211002695

Department of Periodontics, SRM Dental College, Ramapuram, Chennai, Tamilnadu, India.

Over the past several decades, studies have demonstrated the existence of bi-directional relationships between periodontal disease and systemic conditions. Periodontitis is a polymicrobial and multifactorial disease involving both host and environmental factors. Tissue destruction is primarily associated with hyperresponsiveness of the host resulting in release of inflammatory mediators. Read More

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Task syndromes: linking personality and task allocation in social animal groups.

Behav Ecol 2021 Jan-Feb;32(1):1-17. Epub 2021 Feb 6.

Department of Environmental Science and Policy, University of California at Davis, Davis, CA, USA.

Studies of eusocial insects have extensively investigated two components of task allocation: how individuals distribute themselves among different tasks in a colony and how the distribution of labor changes to meet fluctuating task demand. While discrete age- and morphologically-based task allocation systems explain much of the social order in these colonies, the basis for task allocation in non-eusocial organisms and within eusocial castes remains unknown. Building from recent advances in the study of among-individual variation in behavior (i. Read More

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February 2021

Fatty Pancreas: An Underappreciated Intersection of the Metabolic Profile and Pancreatic Adenocarcinoma.

Arthur Swislocki

Metab Syndr Relat Disord 2021 Mar 3. Epub 2021 Mar 3.

Medical Service (612/111), Veterans Affairs Northern California Health Care System (VANCHCS), Martinez, California, USA.

Although the prevalence of pancreatic cancer is increasing, treatment strategies remain limited, and success is rare. A growing body of evidence links pancreatic cancer to pre-existing metabolic disorders, including, but not limited to, type 2 diabetes mellitus and obesity. An infrequently described finding, fatty pancreas, initially described in the context of obesity in the early 20th century, appears to be at the crossroads of type 2 diabetes and obesity on the one hand, and the development of pancreatic cancer on the other. Read More

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Exploring miRNA-related Molecular Targets of Erchen Decoction against Lipid Metabolism Disorder using A Network Pharmacologic Approach.

Comb Chem High Throughput Screen 2021 Mar 1. Epub 2021 Mar 1.

Research Base of Traditional Chinese Medicine Syndrome, Fujian University of Traditional Chinese Medicine, Fuzhou 350122. China.

Background: Erchen Decoction (ECD) is a complex herbal formulation widely used for treating lipid metabolism disorder (LMD) in China. This study aims to explore the microRNA (miRNA)-related molecular targets of ECD against LMD using a network pharmacology approach (NPA) Methods: We randomly divided 20 male Sprague Dawley rats into two groups; 10 rats were normal controls, and the other 10 rats were fed a high-fat diet (HFD) for 12 weeks to establish an LMD model. Differentially expressed miRNAs (DE-miRs, HFD vs. Read More

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[The prevalence and risk of sleep disorders in patients with functional dyspepsia: a meta-analysis].

Zh Nevrol Psikhiatr Im S S Korsakova 2021 ;121(1):26-30

Evdokimov Moscow State Medical and Dentistry University, Moscow, Russia.

Objective: Systematization of data on the incidence and risk of sleep disorders in patients with functional dyspepsia (FD).

Material And Methods: Studies were searched in the electronic databases MEDLINE/PubMed, EMBASE, Cochrane until October 2020. Publications with detailed descriptive statistics (sample size, number of patients with sleep disorders) were selected for the final analysis, allowing the resulting data to be included in the meta-analysis. Read More

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February 2021

The intersection between integrative medicine and neuropathic pain: A case report.

Explore (NY) 2021 Jan 23. Epub 2021 Jan 23.

George Washington University, United States. Electronic address:

Introduction: Neuropathic pain is a debilitating condition caused by lesion or disease of the somatosensory nervous system. Integrative modalities such as yoga, acupuncture, and massage are evidenced therapies for pain management. Additionally, medical cannabis and cannabinoids are emerging therapies for treatment of neuropathic pain (4,28). Read More

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January 2021