293 results match your criteria Intersection Syndrome


Activity-Dependent Remodeling of Olfactory Sensory Neuron Brain Innervation During an Early-Life Critical Period.

J Neurosci 2019 Feb 12. Epub 2019 Feb 12.

Vanderbilt Brain Institute

Critical periods are windows of development when the environment has a pronounced effect on brain circuitry. Models of neurodevelopmental disorders including autism spectrum disorders, intellectual disabilities and schizophrenia are linked to disruption of critical period remodeling. Critical periods open with the onset of sensory experience, however it remains unclear exactly how sensory input modifies brain circuits. Read More

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http://dx.doi.org/10.1523/JNEUROSCI.2223-18.2019DOI Listing
February 2019
3 Reads

[Expression and Function of miR-99a-5p in Bone Marrow of Patients with MDS].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2019 Feb;27(1):134-140

Department of Hematology, The First Affliated Hospital, Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China.E-mail:

Objective: To detect the expression of miR-99a-5p in myelodysplastic syndrome (MDS), to predict the target genes and to analyze its function by using bioinformatics.

Methods: The expression levels of bone marrow miR-99a-5p in MDS patients were detected by qRT-PCR, and the correlation of miR-99a-5p expression with clinical pathological characteristics, percentage of marrow blasts , chromosome karyotype and peripheral blood hemogram were analyzed. The target genes of miR-99a-5p were predicted by Targetscan, Miranda and Microcosm, and the intersection of the predicted results of 3 softwares was used as a potential target gene for miR-99a-5p. Read More

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http://dx.doi.org/10.7534/j.issn.1009-2137.2019.01.022DOI Listing
February 2019
2 Reads

Towards a better diagnosis and treatment of Rett syndrome: a model synaptic disorder.

Brain 2019 Feb;142(2):239-248

Department of Human Genetics, Emory University School of Medicine, Atlanta GA, USA.

With the recent 50th anniversary of the first publication on Rett syndrome, and the almost 20 years since the first report on the link between Rett syndrome and MECP2 mutations, it is important to reflect on the tremendous advances in our understanding and their implications for the diagnosis and treatment of this neurodevelopmental disorder. Rett syndrome features an interesting challenge for biologists and clinicians, as the disorder lies at the intersection of molecular mechanisms of epigenetic regulation and neurophysiological alterations in synapses and circuits that together contribute to severe pathophysiological endophenotypes. Genetic, clinical, and neurobiological evidences support the notion that Rett syndrome is primarily a synaptic disorder, and a disease model for both intellectual disability and autism spectrum disorder. Read More

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https://academic.oup.com/brain/advance-article/doi/10.1093/b
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http://dx.doi.org/10.1093/brain/awy323DOI Listing
February 2019
5 Reads

Best Practices in Fragile X Syndrome Treatment Development.

Brain Sci 2018 Dec 15;8(12). Epub 2018 Dec 15.

Departments of Pediatrics, Neurological Sciences, Biochemistry, Rush University Medical Center, Chicago, IL 60612, USA.

Preclinical studies using animal models of fragile X syndrome have yielded several agents that rescue a wide variety of phenotypes. However, translation of these treatments to humans with the disorder has not yet been successful, shedding light on a variety of limitations with both animal models and human trial design. As members of the Clinical Trials Committee of the National Fragile X Foundation, we have discussed a variety of recommendations at the level of preclinical development, transition from preclinical to human projects, family involvement, and multi-site trial planning. Read More

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http://dx.doi.org/10.3390/brainsci8120224DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315698PMC
December 2018
2 Reads

Functional significance of channelopathy gene variants in unexplained death.

Forensic Sci Med Pathol 2018 Dec 13. Epub 2018 Dec 13.

Pediatrics, NYU School of Medicine, 450 E 29th Street, ACLS 824, New York, NY, 10016, USA.

Determining the cause of unexplained death in all age groups, including infants, is a priority in forensic medicine. The triple risk model proposed for sudden infant death syndrome involves the intersection of three risks: (1) a critical developmental period in homeostatic control (2), exogenous stressors, and (3) a vulnerable infant. Even though sex and age factor into some forms of inherited arrhythmogenic deaths in young individuals and adults, more appropriate a dual-risk disease model for adults involves exogenous stressors and a vulnerable individual. Read More

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http://link.springer.com/10.1007/s12024-018-0063-y
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http://dx.doi.org/10.1007/s12024-018-0063-yDOI Listing
December 2018
12 Reads

Polygenic risk score identifies associations between sleep duration and diseases determined from an electronic medical record biobank.

Sleep 2018 Dec 5. Epub 2018 Dec 5.

Center for Genomic Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA USA.

Study Objectives: We aimed to detect cross-sectional phenotype and polygenic risk score (PRS) associations between sleep duration and prevalent diseases using the Partners Biobank, a hospital-based cohort study linking electronic medical record (EMR) with genetic information.

Methods: Disease prevalence was determined from EMR, and sleep duration was self-reported. A PRS for sleep duration was derived using 78 previously associated SNPs from GWAS for self-reported sleep duration. Read More

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http://dx.doi.org/10.1093/sleep/zsy247DOI Listing
December 2018
4 Reads

An emerging viral pathogen truncates population age structure in a European amphibian and may reduce population viability.

PeerJ 2018 16;6:e5949. Epub 2018 Nov 16.

Institute of Zoology, Zoological Society of London, London, UK.

Infectious diseases can alter the demography of their host populations, reducing their viability even in the absence of mass mortality. Amphibians are the most threatened group of vertebrates globally, and emerging infectious diseases play a large role in their continued population declines. Viruses belonging to the genus are responsible for one of the deadliest and most widespread of these diseases. Read More

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https://peerj.com/articles/5949
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http://dx.doi.org/10.7717/peerj.5949DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6241393PMC
November 2018
17 Reads

integRATE: a desirability-based data integration framework for the prioritization of candidate genes across heterogeneous omics and its application to preterm birth.

BMC Med Genomics 2018 Nov 19;11(1):107. Epub 2018 Nov 19.

Department of Biological Sciences, Vanderbilt University, Nashville, TN, USA.

Background: The integration of high-quality, genome-wide analyses offers a robust approach to elucidating genetic factors involved in complex human diseases. Even though several methods exist to integrate heterogeneous omics data, most biologists still manually select candidate genes by examining the intersection of lists of candidates stemming from analyses of different types of omics data that have been generated by imposing hard (strict) thresholds on quantitative variables, such as P-values and fold changes, increasing the chance of missing potentially important candidates.

Methods: To better facilitate the unbiased integration of heterogeneous omics data collected from diverse platforms and samples, we propose a desirability function framework for identifying candidate genes with strong evidence across data types as targets for follow-up functional analysis. Read More

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http://dx.doi.org/10.1186/s12920-018-0426-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245874PMC
November 2018
2 Reads

Toward Precision Medicine in the Cardiorenal Syndrome.

Adv Chronic Kidney Dis 2018 Sep;25(5):418-424

Division of Cardiovascular Medicine, Department of Medicine, University of California San Diego, La Jolla, CA; and Division of Nephrology-Hypertension, Department of Medicine, University of California San Diego, San Diego, California. Electronic address:

Although the field of oncology has made significant steps toward individualized precision medicine, cardiology and nephrology still often use a "one size fits all" approach. This applies to the intersection of the heart-kidney interaction and the cardiorenal syndrome as well. Recent studies have shown that the prognostic implications of worsening renal function (WRF) in acute heart failure are variable; thus, there is a need to differentiate the implications of WRF to better guide precise care. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15485595183015
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http://dx.doi.org/10.1053/j.ackd.2018.08.017DOI Listing
September 2018
5 Reads

Proceedings of the fifth international RASopathies symposium: When development and cancer intersect.

Am J Med Genet A 2018 Dec 10;176(12):2924-2929. Epub 2018 Oct 10.

Department of Ophthalmology, Neuroscience Program, University of California, San Francisco, San Francisco, California.

This report summarizes and highlights the fifth International RASopathies Symposium: When Development and Cancer Intersect, held in Orlando, Florida in July 2017. The RASopathies comprise a recognizable pattern of malformation syndromes that are caused by germ line mutations in genes that encode components of the RAS/mitogen-activated protein kinase (MAPK) pathway. Because of their common underlying pathogenetic etiology, there is significant overlap in their phenotypic features, which includes craniofacial dysmorphology, cardiac, cutaneous, musculoskeletal, gastrointestinal and ocular abnormalities, neurological and neurocognitive issues, and a predisposition to cancer. Read More

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http://doi.wiley.com/10.1002/ajmg.a.40632
Publisher Site
http://dx.doi.org/10.1002/ajmg.a.40632DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312476PMC
December 2018
14 Reads

Anomalous course and stenosing tenosynovitis of the extensor pollicis longus tendon at the radial styloid process: A case report.

Medicine (Baltimore) 2018 Sep;97(37):e12128

The Research Center for Advanced Image and Information Technology, School of Electronics & Information Engineering, Chonbuk National University, Jeonju, Chonbuk, Republic of Korea.

Rationale: Anomalous course and tenosynovitis of extensor pollicis longus (EPL) tendon is a rare condition that presents clinical symptoms very similar to de Quervain's disease. Herein we report a case of anomalous course and tenosynovitis of the extensor pollicis longus (EPL) tendon associated with symptoms of de Quervain's disease.

Patient Concerns: A 44-year-old right-handed man visited the clinic because of radial pain associated with the left wrist, which was aggravated during the previous 10 days. Read More

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http://dx.doi.org/10.1097/MD.0000000000012128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156004PMC
September 2018
15 Reads

Flexor carpi radialis brevis: a rare accessory muscle presenting as an intersection syndrome of the wrist.

Skeletal Radiol 2019 Mar 10;48(3):457-460. Epub 2018 Aug 10.

Department of Radiology, University of California San Diego, 408 Dickinson Street, Mail code 8226, San Diego, CA, 92103, USA.

The flexor carpi radialis brevis (FCRB) is a rare accessory muscle of the forearm and wrist. It is typically asymptomatic, but has been discovered either incidentally during cadaveric studies or at the time of surgery in patients with distal forearm injury. Rarely, the FCRB muscle is associated with pain. Read More

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http://link.springer.com/10.1007/s00256-018-3034-1
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http://dx.doi.org/10.1007/s00256-018-3034-1DOI Listing
March 2019
16 Reads

Brief Review: Ergospirometry in Patients with Obstructive Sleep Apnea Syndrome.

J Clin Med 2018 Jul 31;7(8). Epub 2018 Jul 31.

Laboratory of Cardio-Pulmonary Testing, Department of Respiratory Medicine, University of Thessaly, Larissa 41110, Greece.

This brief review summarizes the available literature on the intersection of obstructive sleep apnea syndrome (OSAS) and ergospirometry. Ergospirometry provides an assessment of integrative exercise responses involving pulmonary, cardiovascular, neuropsychological, and skeletal muscle systems, which are not adequately reflected through the measurement of individual organ system functions. Sleep disorders, including OSAS, often exacerbate problems in the operation of the autonomic nervous system, heart function, lung mechanics, anxiety, and muscle metabolism. Read More

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http://dx.doi.org/10.3390/jcm7080191DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6111535PMC
July 2018
19 Reads

Interstitial Pneumonia With Autoimmune Features: An Emerging Challenge at the Intersection of Rheumatology and Pulmonology.

Arthritis Rheumatol 2018 Dec 27;70(12):1901-1913. Epub 2018 Oct 27.

Vanderbilt University, Nashville, Tennessee.

Interstitial lung disease (ILD) remains a cause of significant morbidity and mortality in patients with connective tissue disease (CTD)-associated ILD. While some patients meet clear classification criteria for a systemic rheumatic disease, a subset of patients do not meet classification criteria but still benefit from immunosuppressive therapy. In 2015, the American Thoracic Society and European Respiratory Society described classification criteria for interstitial pneumonia with autoimmune features (IPAF) to identify patients with lung-predominant CTD who lack sufficient features of a systemic rheumatic disease to meet classification criteria. Read More

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http://dx.doi.org/10.1002/art.40679DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261671PMC
December 2018
12 Reads

[Intersection syndrome in a tetraplegic hand cyclist].

Ugeskr Laeger 2018 Jun;180(25)

Wrist tendinopathies are common overuse injuries in athletes and often associated with activities such as rowing, riding or racket sports. Correctly diagnosing the various tendinopathies is essential for management of cases refractory to initial treatment. Easily mistaken for de Quervain's tenosynovitis, the intersection syndrome may be effectively managed by simple taping negating the need for corticosteroid injection and tendon release surgery. Read More

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June 2018
5 Reads

Gene-environment interaction of monoamine oxidase A in relation to antisocial behaviour: current and future directions.

J Neural Transm (Vienna) 2018 Nov 7;125(11):1601-1626. Epub 2018 Jun 7.

Department of Neuroscience, Uppsala University, Uppsala, Sweden.

Since the pioneering finding of Caspi and co-workers in 2002 that exposure to childhood maltreatment predicted later antisocial behaviour (ASB) in male carriers of the low-activity MAOA-uVNTR allele, frequent replication studies have been published. Two meta-analyses, one in 2006 and the other in 2014, confirmed the original findings by Caspi and co-workers. In the present paper, we review the literature, note some methodological aspects of candidate gene-environment interaction (cG×E) studies and suggest some future directions. Read More

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http://dx.doi.org/10.1007/s00702-018-1892-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224008PMC
November 2018
4 Reads

Three-dimensional Photogrammetric Analysis of Facial Soft-to-Hard Tissue Ratios After Bimaxillary Surgery in Facial Asymmetry Patients With and Without Sturge-Weber Syndrome.

Ann Plast Surg 2018 Aug;81(2):178-185

Eastman Dental Clinic, Seoul, Korea.

Sturge-Weber syndrome (SWS) is a rare neurocutaneous syndrome characterized by facial port-wine stains. Most patients with facial asymmetry due to SWS have soft and/or hard tissue hypertrophy and require both soft tissue correction and bone surgery. In our experience, because SWS patients are more likely than non-SWS patients to be dissatisfied after bone surgery because of limited soft tissue change, we compared soft tissue changes after bimaxillary surgery between facial asymmetry patients with and without SWS. Read More

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http://Insights.ovid.com/crossref?an=00000637-900000000-9736
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http://dx.doi.org/10.1097/SAP.0000000000001484DOI Listing
August 2018
10 Reads

Handedness-dependent functional organizational patterns within the bilateral vestibular cortical network revealed by fMRI connectivity based parcellation.

Neuroimage 2018 09 19;178:224-237. Epub 2018 May 19.

Department of Neurology, Ludwig-Maximilians Universität, Munich, Germany; Graduate School of Systemic Neuroscience, Ludwig-Maximilians Universität, Munich, Germany; German Center for Vertigo and Balance Disorders-IFB(LMU), Ludwig-Maximilians Universität, Munich, Germany; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.

Current evidence points towards a vestibular cortex that involves a multisensory bilateral temporo-parietal-insular network with a handedness-dependent hemispheric lateralization. This study aimed to identify handedness-dependent organizational patterns of (lateralized and non-lateralized) functional subunits within the human vestibular cortex areas. 60 healthy volunteers (30 left-handed and 30 right-handed) were examined on a 3T MR scanner using resting state functional MRI (fMRI). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10538119183041
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http://dx.doi.org/10.1016/j.neuroimage.2018.05.018DOI Listing
September 2018
9 Reads

Clopidogrel Pharmacogenetics in Iranian Patients Undergoing Percutaneous Coronary Intervention.

Cardiovasc Toxicol 2018 10;18(5):482-491

Medical Genetics Laboratory, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Valiasr Street, Niyaesh Intersection, Tehran, 1995614331, Iran.

Clopidogrel is used in patients with coronary syndromes and at risk of thrombotic events or receiving percutaneous coronary intervention (PCI) for reducing heart attack and stroke. Here we present genotype and phenotype study of Iranian patients undergoing PCI treated with clopidogrel during a 6-month period of follow-up; common variants of CYP2C19, CYP3A5, CYP3A4, and ABCB1 genes were determined as well as the patients' cardiovascular outcomes to find out the effect of these variants individually and in combination. 388 individuals receiving PCI were enrolled in this study. Read More

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http://dx.doi.org/10.1007/s12012-018-9459-xDOI Listing
October 2018
7 Reads

Advances in Biomarker-Guided Therapy for Pediatric- and Adult-Onset Neuroinflammatory Disorders: Targeting Chemokines/Cytokines.

Front Immunol 2018 4;9:557. Epub 2018 Apr 4.

National Pediatric Neuroinflammation Organization, Inc., Orlando, FL, United States.

The concept and recognized components of "neuroinflammation" are expanding at the intersection of neurobiology and immunobiology. Chemokines (CKs), no longer merely necessary for immune cell trafficking and positioning, have multiple physiologic, developmental, and modulatory functionalities in the central nervous system (CNS) through neuron-glia interactions and other mechanisms affecting neurotransmission. They issue the "help me" cry of neurons and astrocytes in response to CNS injury, engaging invading lymphoid cells (T cells and B cells) and myeloid cells (dendritic cells, monocytes, and neutrophils) (adaptive immunity), as well as microglia and macrophages (innate immunity), in a cascade of events, some beneficial (reparative), others destructive (excitotoxic). Read More

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http://dx.doi.org/10.3389/fimmu.2018.00557DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5893838PMC
April 2018
26 Reads

Distal intersection syndrome: An unusual cause of forearm pain.

Reumatol Clin 2018 Apr 4. Epub 2018 Apr 4.

Servicio de Reumatología, Hospital Universitario Ramón y Cajal, Madrid, España.

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http://dx.doi.org/10.1016/j.reuma.2018.02.001DOI Listing
April 2018
5 Reads

Phenotypic characterization of patients with rheumatologic manifestations of common variable immunodeficiency.

Semin Arthritis Rheum 2018 10 23;48(2):318-326. Epub 2018 Feb 23.

Divisions of Rheumatology and Allergy and Clinical Immunology, Johns Hopkins University School of Medicine, Baltimore, MD.

Patients with common variable immunodeficiency (CVID) have a higher incidence of rheumatologic disorders. To delineate this clinical association, we investigated the phenotypic features of patients with CVID affected by these conditions.

Methods: We conducted a retrospective analysis of 870 pediatric and adult patients with CVID included in the United States Immunodeficiency Network (USIDNET) registry. Read More

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http://dx.doi.org/10.1016/j.semarthrit.2018.02.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6107427PMC
October 2018
14 Reads

Whole-exome sequencing for monozygotic twins discordant for hemifacial microsomia.

J Craniomaxillofac Surg 2018 May 16;46(5):802-807. Epub 2018 Feb 16.

Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, People's Republic of China. Electronic address:

Hemifacial microsomia (HFM) is the second most common congenital craniofacial malformation. Although many sporadic and familial cases have been studied to explore the etiology and pathogenesis of HFM, no common understanding has been reached. We aimed to further probe into the etiology of HFM through studying monozygotic twins. Read More

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http://dx.doi.org/10.1016/j.jcms.2018.02.005DOI Listing
May 2018
8 Reads
2.600 Impact Factor

Using genes to triangulate the pathophysiology of granulomatous autoinflammatory disease: NOD2, PLCG2 and LACC1.

Int Immunol 2018 04;30(5):205-213

Translational Genetics and Genomics Unit, Intramural Research Program, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, US Department of Health & Human Services, Bethesda, MD, USA.

The intersection of granulomatosis and autoinflammatory disease is a rare occurrence that can be generally subdivided into purely granulomatous phenotypes and disease spectra that are inclusive of granulomatous features. NOD2 (nucleotide-binding oligomerization domain-containing protein 2)-related disease, which includes Blau syndrome and early-onset sarcoidosis, is the prototypic example of granulomatous inflammation in the context of monogenic autoinflammation. Granulomatous inflammation has also been observed in two related autoinflammatory diseases caused by mutations in PLCG2 (phospholipase Cγ2). Read More

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http://dx.doi.org/10.1093/intimm/dxy021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6281334PMC
April 2018
6 Reads

Mechanisms and consequences of oxidative stress in lung disease: therapeutic implications for an aging populace.

Authors:
Louise Hecker

Am J Physiol Lung Cell Mol Physiol 2018 04 14;314(4):L642-L653. Epub 2017 Dec 14.

Division of Pulmonary, Allergy and Critical Care and Sleep Medicine, University of Arizona , Tucson, Arizona and Southern Arizona Veterans Affairs Health Care System, Tucson, Arizona.

The rapid expansion of the elderly population has led to the recent epidemic of age-related diseases, including increased incidence and mortality of chronic and acute lung diseases. Numerous studies have implicated aging and oxidative stress in the pathogenesis of various pulmonary diseases; however, despite recent advances in these fields, the specific contributions of aging and oxidative stress remain elusive. This review will discuss the consequences of aging on lung morphology and physiology, and how redox imbalance with aging contributes to lung disease susceptibility. Read More

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http://dx.doi.org/10.1152/ajplung.00275.2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5966777PMC
April 2018
8 Reads

Intersection Syndrome Revisited: Let's Talk Much More About It Using Ultrasound.

Am J Phys Med Rehabil 2018 Sep;97(9):e89

From the Istanbul Physical and Rehabilitation Medicine Training and Research Hospital, İstanbul, Turkey (MS); Department of Physical and Rehabilitation Medicine, Hacettepe University Medical School, Ankara, Turkey (MS, SÖ, GA, MK, LÖ); and Department of Physical and Rehabilitation Medicine, Yildirim Beyazit University Medical School, Ankara, Turkey (GA).

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http://dx.doi.org/10.1097/PHM.0000000000000891DOI Listing
September 2018
9 Reads

Cardiovascular autonomic dysfunction in sudden infant death syndrome.

Clin Auton Res 2018 Dec 3;28(6):535-543. Epub 2018 Jan 3.

The Ritchie Centre, Department of Paediatrics and Hudson Institute of Medical Research, Monash University, Melbourne, Australia.

A failure of cardiorespiratory control mechanisms, together with an impaired arousal response from sleep, are believed to play an important role in the final event of sudden infant death syndrome (SIDS). The 'triple risk model' describes SIDS as an event that results from the intersection of three overlapping factors: (1) a vulnerable infant, (2) a critical developmental period in homeostatic control and (3) an exogenous stressor. In an attempt to understand how the triple risk hypothesis is related to infant cardiorespiratory physiology, many researchers have examined how the known risk and protective factors for SIDS alter infant cardiovascular control during sleep. Read More

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http://dx.doi.org/10.1007/s10286-017-0490-yDOI Listing
December 2018
9 Reads

Delirium pathophysiology: An updated hypothesis of the etiology of acute brain failure.

Int J Geriatr Psychiatry 2018 11 26;33(11):1428-1457. Epub 2017 Dec 26.

Stanford University School of Medicine, Stanford, CA, USA.

Background: Delirium is the most common neuropsychiatric syndrome encountered by clinicians dealing with older adults and the medically ill and is best characterized by 5 core domains: cognitive deficits, attentional deficits, circadian rhythm dysregulation, emotional dysregulation, and alteration in psychomotor functioning.

Design: An extensive literature review and consolidation of published data into a novel interpretation of known pathophysiological causes of delirium.

Results: Available data suggest that numerous pathological factors may serve as precipitants for delirium, each having differential effects depending on patient-specific patient physiological characteristics (substrate). Read More

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http://dx.doi.org/10.1002/gps.4823DOI Listing
November 2018
13 Reads

Mitochondrial Dysfunction Linking Obesity and Asthma.

Ann Am Thorac Soc 2017 Nov;14(Supplement_5):S368-S373

1 CSIR Institute of Genomics and Integrative Biology, Delhi, India.

The bidirectional epidemiological association between asthma and obesity is well known. Recent evidence suggests that there is an intersection of the pathophysiological molecular pathways leading to either obesity or asthma, at the level of mitochondria. This is not surprising, because mitochondria, beyond their roles as the metabolic powerhouses of the cell, serve as sensors of threats, regulators of stress signaling, and effectors of cytotoxicity. Read More

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http://dx.doi.org/10.1513/AnnalsATS.201701-042AWDOI Listing
November 2017
12 Reads

The Intersection of Intellectual Disability and Dementia: Report of The International Summit on Intellectual Disability and Dementia.

Gerontologist 2017 Nov 2. Epub 2017 Nov 2.

Department of Disability and Human Development, University of Illinois at Chicago, Chicago, IL.

An International Summit on Intellectual Disability and Dementia, held in Glasgow, Scotland (October 13-14, 2016), drew individuals and representatives of numerous international and national organizations and universities with a stake in issues affecting adults with intellectual disability (ID) affected by dementia. A discussion-based consensus process was used to examine and produce a series of topical reports examining three main conceptual areas: (a) human rights and personal resources (applications of the Convention for Rights of People with Disabilities and human rights to societal inclusion, and perspectives of persons with ID), (b) individualized services and clinical supports (advancing and advanced dementia, post-diagnostic supports, community supports and services, dementia-capable care practice, and end-of-life care practices), and (c) advocacy, public impact, family caregiver issues (nomenclature/terminology, inclusion of persons with ID in national plans, and family caregiver issues). Outcomes included recommendations incorporated into a series of publications and topical summary bulletins designed to be international resources, practice guidelines, and the impetus for planning and advocacy with, and on behalf of, people with ID affected by dementia, as well as their families. Read More

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http://dx.doi.org/10.1093/geront/gnx160DOI Listing
November 2017
10 Reads

Down Syndrome and Alzheimer's Disease: Issues and Implications for Social Work Practice.

J Gerontol Soc Work 2018 01 21;61(1):4-10. Epub 2017 Nov 21.

a George Warren Brown School of Social Work , Washington University , St. Louis , United States.

Owing to recent medical advancements, people with Down Syndrome (DS) are now able to live considerably longer lives and thus experience a variety of complex issues as they age. Alzheimer's Disease (AD) frequently occurs in older adults who have DS, but few practice guidelines exist to inform social work practice with older adults who have this dual diagnosis. This commentary will highlight the connection between these two conditions within a neurobiological framework and discuss implications for practice based on the available literature on this intersection of ability status, cognitive status, and age. Read More

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http://dx.doi.org/10.1080/01634372.2017.1393480DOI Listing
January 2018
10 Reads

Innovation at the Intersection of Alcohol and HIV Research.

AIDS Behav 2017 Nov;21(Suppl 2):274-278

Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California at Los Angeles, Los Angeles, CA, USA.

Working in an interdisciplinary manner at the crossroads of alcohol and HIV research is a challenge. This paper presents six novel approaches that could be applied to activities at the intersection of alcohol and HIV. These approaches are (i) address the fact that the availability of new technology is unevenly distributed around the world, (ii) use technology to move beyond both paper and digital surveys, (iii) introduce a focus on advocacy and partnerships with large technology companies, (iv) harness technological innovation to utilise digital counselling, (v) explore the use of virtual reality in both research and delivering interventions, and (vi) consider alternative funding models to those currently in existence to improve efficiencies and innovations. Read More

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http://dx.doi.org/10.1007/s10461-017-1926-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5660130PMC
November 2017
10 Reads

Research Priorities for the Intersection of Alcohol and HIV/AIDS in Low and Middle Income Countries: A Priority Setting Exercise.

AIDS Behav 2017 Nov;21(Suppl 2):262-273

The Department of Psychology, Stellenbosch University, Private Bag X1, Matieland, 7602, South Africa.

The harmful use of alcohol is a component cause for more than 200 diseases. The association between alcohol consumption, risk taking behavior and a range of infectious diseases such as HIV/AIDS is well established. The prevalence of HIV/AIDS as well as harmful alcohol use in low and middle income countries is high. Read More

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http://dx.doi.org/10.1007/s10461-017-1921-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5660137PMC
November 2017
9 Reads

Distal intersection syndrome progressing to extensor pollicis longus tendon rupture: a case report with sonographic findings.

J Ultrasound 2017 Sep 8;20(3):237-241. Epub 2016 Dec 8.

Department of Radiology, Logan University, 1851 Schoettler Road, Chesterfield, MO 63017 USA.

The purpose of this case report is to describe the value of musculoskeletal ultrasound (US) in diagnosing both distal intersection syndrome (DIS) and rupture of the extensor pollicis longus (EPL) tendon in the same patient. A 38-year-old female presented for evaluation of a painful bump of unknown etiology on the dorsolateral aspect of her non-dominant wrist. US demonstrated tenosynovitis distal to Lister's tubercle of the EPL and extensor carpi radialis tendon sheaths, consistent with DIS. Read More

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http://dx.doi.org/10.1007/s40477-016-0223-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5573695PMC
September 2017
29 Reads

Synthesis of evidence for the treatment of intersection syndrome.

World J Orthop 2017 Aug 18;8(8):619-623. Epub 2017 Aug 18.

Konstantine Balakatounis, Neurology Institute of Athens, 10676 Athens, Greece.

Intersection syndrome is a rare sports overuse injury occurring through friction at the intersection of the first and second compartment of the forearm. Differential diagnosis must be carefully made, especially from De Quervain tendonsynovitis. Clinical examination provides with the necessary information for diagnosis, still magnetic resonance imaging scans and ultrasonography may assist in diagnosis. Read More

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http://www.wjgnet.com/2218-5836/full/v8/i8/619.htm
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http://dx.doi.org/10.5312/wjo.v8.i8.619DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5565493PMC
August 2017
15 Reads

Behavioral Markers of Emergent Stranger Anxiety in Infants and Toddlers with Fragile X Syndrome.

J Autism Dev Disord 2017 Nov;47(11):3646-3658

Department of Psychology, University of South Carolina, 1512 Pendleton Street, Columbia, SC, 29201, USA.

Studying anxiety in neurogenetic syndromes may inform the intersection of biological and developmental risks, facilitating effective and targeted interventions. We longitudinally examined stranger fear in infants and toddlers with fragile X syndrome (FXS; n = 46) and typical controls (n = 33), as well as associations between observed stranger fear and rating scales of anxiety, withdrawal and autism features within FXS. Results indicated atypical facial fear in FXS, although facial fear did not index anxiety, autistic symptoms or social withdrawal. Read More

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http://dx.doi.org/10.1007/s10803-017-3270-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152811PMC
November 2017
7 Reads

Gout and Metabolic Syndrome: a Tangled Web.

Curr Rheumatol Rep 2017 Aug 26;19(10):60. Epub 2017 Aug 26.

Crystal Diseases Study Group, Division of Rheumatology, Department of Medicine, New York University School of Medicine, 301 East 17th Street, Suite 1410, New York, NY, 10003, USA.

Purpose Of Review: The complexity of gout continues to unravel with each new investigation. Gout sits at the intersection of multiple intrinsically complex processes, and its prevalence, impact on healthcare costs, and association with important co-morbidities make it increasingly relevant. The association between gout and type 2 diabetes, hypertension, hyperlipidemia, cardiovascular disease, renal disease, and obesity suggest that either gout, or its necessary precursor hyperuricemia, may play an important role in the manifestations of the metabolic syndrome. Read More

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http://dx.doi.org/10.1007/s11926-017-0688-yDOI Listing
August 2017
27 Reads

Glycerol-3-phosphate phosphatase/PGP: Role in intermediary metabolism and target for cardiometabolic diseases.

Biochimie 2017 Dec 5;143:18-28. Epub 2017 Aug 5.

Department of Nutrition, Montreal Diabetes Research Center, CRCHUM, 900 St-Denis (Viger Tower), Montréal, QC H1W 4A4, Canada; Department of Biochemistry and Molecular Medicine, Montreal Diabetes Research Center, CRCHUM, 900 St-Denis (Viger Tower), Montréal, QC H1W 4A4, Canada. Electronic address:

Metabolic diseases, including obesity, type 2 diabetes, and metabolic syndrome arise because of disturbances in glucose and fat metabolism, which impact associated physiological events such as insulin secretion and action, fat storage and oxidation. Even though, decades of research has contributed to our current understanding of the components involved in glucose and fat metabolism and their regulation, that led to the development of many therapeutics, there are still many unanswered questions. Glycerol-3-phosphate (Gro3P), which is formed during glycolysis, is at the intersection of glucose and fat metabolism, and the availability of this metabolite can regulate energy and intermediary metabolism in mammalian cells. Read More

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http://dx.doi.org/10.1016/j.biochi.2017.08.001DOI Listing
December 2017
27 Reads

Partial uniparental isodisomy of chromosome 16 unmasks a deleterious biallelic mutation in IFT140 that causes Mainzer-Saldino syndrome.

Hum Genomics 2017 07 19;11(1):16. Epub 2017 Jul 19.

Center for Human Disease Modeling, Duke University Medical Center, Durham, NC, 27701, USA.

Background: The ciliopathies represent an umbrella group of >50 clinical entities that share both clinical features and molecular etiology underscored by structural and functional defects of the primary cilium. Despite the advances in gene discovery, this group of entities continues to pose a diagnostic challenge, in part due to significant genetic and phenotypic heterogeneity and variability. We consulted a pediatric case from asymptomatic, non-consanguineous parents who presented as a suspected ciliopathy due to a constellation of retinal, renal, and skeletal findings. Read More

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http://dx.doi.org/10.1186/s40246-017-0111-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5517791PMC
July 2017
16 Reads

Intersection Syndrome: The Subtle Squeak of an Overused Wrist.

Authors:
Thomas M Skinner

J Am Board Fam Med 2017 Jul-Aug;30(4):547-551

From the US Air Force, 48th Medical Group, Royal Air Force Lakenheath, Suffolk, United Kingdom.

Patient histories that include wrist pain can be pivotal in the distinction between intersection syndrome (IS) and the more common de Quervain's tenosynovitis (DQT). Presented here is a 26-year-old pregnant woman with a history of rowing who developed left radial/dorsal wrist pain and a rubbing/squeaking sensation. Nine months of conservative DQT therapy and a landmark-guided corticosteroid injection failed to relieve her symptoms. Read More

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http://dx.doi.org/10.3122/jabfm.2017.04.170053DOI Listing
February 2018
28 Reads

Sonography of Non-neoplastic Disorders of the Hand and Wrist Tendons.

J Ultrasound Med 2018 Jan 14;37(1):51-68. Epub 2017 Jul 14.

Radiology Institute, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, Università Degli Studi di Pavia, Pavia, Italy.

Tendon disorders commonly cause hand and wrist disability and curtail the performance of work-related duties or routine tasks. Imaging is often needed for diagnosis, but it requires knowledge of the complex anatomic structures of the tendons of the hand and wrist as well as familiarity with related disorders. This review article aims to provide medical professionals with guidelines for the sonographic assessment of the tendons of hand and wrist and related disorders. Read More

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http://dx.doi.org/10.1002/jum.14313DOI Listing
January 2018
11 Reads

"Ice Axe Wrist": A Case Report of Intersection Syndrome in 2 Climbers.

Authors:
Anna L Tobin

Wilderness Environ Med 2017 Sep 30;28(3):230-233. Epub 2017 Jun 30.

Penarth Physiotherapy Practice, Penarth, Wales. Electronic address:

Intersection syndrome is an inflammatory condition located at the crossing point between the first and second dorsal compartments in the wrist. It is an uncommon presentation but has been recognized as an injury typical of rowers (when it is named oarsman's wrist) and other sports such as racquet sports, baseball, cycling, hockey, golf, ice hockey, skiing, and softball. It has not been previously described in climbers. Read More

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http://dx.doi.org/10.1016/j.wem.2017.03.016DOI Listing
September 2017
10 Reads

Management of ischemic coronary disease in patients receiving chemotherapy: an uncharted clinical challenge.

Future Cardiol 2017 05 1;13(3):247-257. Epub 2017 Jun 1.

Department of Medicine, Memorial Sloan Kettering Cancer Center, NY 10065, USA.

Acute coronary syndrome (ACS) coinciding with active malignancy presents a unique clinical challenge given intersecting pathophysiology and treatment-related effects. There is little established clinical guidance on management strategies, rendering most treatment approaches anecdotal. We present a case highlighting the complexity of managing a patient being treated for malignancy who concurrently suffers from ACS. Read More

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http://dx.doi.org/10.2217/fca-2017-0002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5618941PMC
May 2017
38 Reads

Exploring syndrome differentiation using non-negative matrix factorization and cluster analysis in patients with atopic dermatitis.

Comput Biol Med 2017 08 22;87:70-76. Epub 2017 May 22.

Department of Ophthalmology, Otorhinolaryngology, and Dermatology of Korean Medicine, Kyung Hee University Hospital at Gangdong, Seoul, 05278, Republic of Korea; Department of Ophthalmology, Otorhinolaryngology and Dermatology of Korean Medicine, Kyung Hee University, Seoul, 130-701, Republic of Korea. Electronic address:

Syndrome differentiation (SD) results in a diagnostic conclusion based on a cluster of concurrent symptoms and signs, including pulse form and tongue color. In Korea, there is a strong interest in the standardization of Traditional Medicine (TM). In order to standardize TM treatment, standardization of SD should be given priority. Read More

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http://dx.doi.org/10.1016/j.compbiomed.2017.05.023DOI Listing
August 2017
18 Reads

Infant pacifiers for reduction in risk of sudden infant death syndrome.

Cochrane Database Syst Rev 2017 04 5;4:CD011147. Epub 2017 Apr 5.

Sydney School of Public Health, University of Sydney, Sydney, NSW, Australia, 2050.

Background: Sudden infant death syndrome (SIDS) has been most recently defined as the sudden unexpected death of an infant less than one year of age, with onset of the fatal episode apparently occurring during sleep, that remains unexplained after a thorough investigation, including the performance of a complete autopsy and a review of the circumstances of death and clinical history. Despite the success of several prevention campaigns, SIDS remains a leading cause of infant mortality. In 1994, a 'triple risk model' for SIDS was proposed that described SIDS as an event that results from the intersection of three factors: a vulnerable infant; a critical development period in homeostatic control (age related); and an exogenous stressor. Read More

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http://dx.doi.org/10.1002/14651858.CD011147.pub2DOI Listing
April 2017
10 Reads

Progressive iron accumulation across multiple sclerosis phenotypes revealed by sparse classification of deep gray matter.

J Magn Reson Imaging 2017 11 16;46(5):1464-1473. Epub 2017 Mar 16.

Department of Biomedical Engineering, University of Alberta, Edmonton, AB, Canada.

Purpose: To create an automated framework for localized analysis of deep gray matter (DGM) iron accumulation and demyelination using sparse classification by combining quantitative susceptibility (QS) and transverse relaxation rate (R2*) maps, for evaluation of DGM in multiple sclerosis (MS) phenotypes relative to healthy controls.

Materials And Methods: R2*/QS maps were computed using a 4.7T 10-echo gradient echo acquisition from 16 clinically isolated syndrome (CIS), 41 relapsing-remitting (RR), 40 secondary-progressive (SP), 13 primary-progressive (PP) MS patients, and 75 controls. Read More

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http://dx.doi.org/10.1002/jmri.25682DOI Listing
November 2017
9 Reads

C9orf72: At the intersection of lysosome cell biology and neurodegenerative disease.

Traffic 2017 05 23;18(5):267-276. Epub 2017 Mar 23.

Department of Cell Biology, Yale University School of Medicine, New Haven, Connecticut.

The discovery that expansion of a hexanucleotide repeat within a noncoding region of the C9orf72 gene causes amyotrophic lateral sclerosis and frontotemporal dementia raised questions about C9orf72 protein function and potential disease relevance. The major predicted structural feature of the C9orf72 protein is a DENN (differentially expressed in normal and neoplastic cells) domain. As DENN domains are best characterized for regulation of specific Rab GTPases, it has been proposed that C9orf72 may also act through regulation of a GTPase target. Read More

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http://dx.doi.org/10.1111/tra.12477DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389918PMC
May 2017
7 Reads

A Review of Anatomical Placement of Corticosteroid Injections for Uncommon Hand, Wrist, and Elbow Pathologies.

R I Med J (2013) 2017 Mar 1;100(2):31-34. Epub 2017 Mar 1.

Department of Orthopaedic Surgery, Brown University/Rhode Island Hospital, Providence, RI.

Corticosteroid injections are a common nonsurgical treatment of intersection syndrome, flexor carpi radialis tendonitis, flexor carpi ulnaris tendonitis, and medial epicondylitis. The benefits of corticosteroid injections for these conditions have been well studied and documented in the medical literature. Patients with less common upper extremity complaints usually first present to their primary care provider. Read More

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March 2017
14 Reads

The prevalence of frailty in heart failure: A systematic review and meta-analysis.

Int J Cardiol 2017 Jun 10;236:283-289. Epub 2017 Feb 10.

Oregon Health & Science University Knight Cardiovascular Institute, Portland, OR, USA; Oregon Health & Science University School of Nursing, Portland, OR, USA.

Background: There is a growing interest in the intersection of heart failure (HF) and frailty; however, estimates of the prevalence of frailty in HF vary widely. The purpose of this paper was to quantitatively synthesize published literature on the prevalence of frailty in HF and to examine the relationship between study characteristics (i.e. Read More

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http://dx.doi.org/10.1016/j.ijcard.2017.01.153DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5392144PMC
June 2017
13 Reads