Pain 2021 Jun 28. Epub 2021 Jun 28.
Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden Department of Neuroradiology, Karolinska University Hospital, Stockholm, Sweden Department of Clinical Sciences, Karolinska Institutet, Danderyd University Hospital, Stockholm, Sweden Department of Medicine, Rheumatology Unit, Center for Molecular Medicine (CMM), Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden Department of Surgical Sciences/Pain Research, Uppsala University, Uppsala, Sweden.
Abstract: The current study used functional magnetic resonance imaging (fMRI) to directly compare disease-relevant cerebral pain processing in well-characterized patient cohorts of fibromyalgia (FM, nociplastic pain) and rheumatoid arthritis (RA, nociceptive pain). Secondary aims were to identify pain-related cerebral alterations related to the severity of clinical symptoms such as pain intensity, depression and anxiety. Twenty-six FM (without RA-comorbidity) and 31 RA (without FM-comorbidity) patients underwent fMRI while stimulated with subjectively calibrated painful pressures corresponding to a pain sensation of 50 mm on a 100 mm VAS scale. Read More