5,999 results match your criteria International urology and nephrology[Journal]


Low serum folic acid can be a potential independent risk factor for erectile dysfunction: a prospective case-control study.

Int Urol Nephrol 2018 Dec 13. Epub 2018 Dec 13.

Andrology & STDs Department, Kasr Al-Ainy Faculty of Medicine, Cairo University, Giza, Egypt.

Purpose: The purpose of the study was to compare serum level of folic acid (FA) in patients with erectile dysfunction (ED) versus healthy controls and to assess its correlation with other well-known confounders for ED.

Methods: Our prospective study compared FA in 60 patients with ED versus 30 healthy controls. Patients were excluded if they had any hormonal disorders, Peyronie's disease, or decompensated systemic illnesses. Read More

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http://dx.doi.org/10.1007/s11255-018-2055-yDOI Listing
December 2018

Vaginoplasty and creating labia minora in children with disorders of sex development.

Int Urol Nephrol 2018 Dec 13. Epub 2018 Dec 13.

Department of Visceral Surgery, Faculty of Medicine, Children's Hospital Canastel, University of Oran, Oran, Algeria.

Purpose: To report current results of vaginoplasty using the mucosa of the prepuce, and creating labia minora by penile skin in children with disorders of sex development (DSD).

Methods: In 10 years, we have performed 22 vaginoplasties using the described technique of vaginoplasty, 21 patients with 46, XX DSD and 1 ovotesticular DSD. The assessment of the results of this technique of vaginoplasty was undertaken in several stages: (a) The evaluation of the cosmetic result. Read More

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http://dx.doi.org/10.1007/s11255-018-2058-8DOI Listing
December 2018
1.293 Impact Factor

Mini-percutaneous nephrolithotomy for pediatric complex renal calculus disease: one-stage or two-stage?

Int Urol Nephrol 2018 Dec 12. Epub 2018 Dec 12.

Department of Urology, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.

Objectives: To compare two different treatment strategies, one-stage and two-stage multi-tract mini-percutaneous nephrolithotomy (mt-mPCNL), for pediatric complex renal calculus disease.

Methods: Between the period of July 2016 and July 2018, a total of 36 children aged 15 years and younger, with complex renal calculi disease, who underwent total ultrasound-guided mt-mPCNL by a single experienced urologist were enrolled in our study. All patients were assigned either to Group 1 (n = 18) who received one-stage mt-mPCNL or Group 2 (n = 18) who received planned two-stage mt-mPCNL. Read More

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http://dx.doi.org/10.1007/s11255-018-2054-zDOI Listing
December 2018

Increased levels of serum pigment epithelium-derived factor aggravate proteinuria via induction of podocyte actin rearrangement.

Int Urol Nephrol 2018 Dec 7. Epub 2018 Dec 7.

Department of Endocrinology, Southwest Hospital, Third Military Medical University (Army Medical University), 29 Gaotanyan Street, Chongqing, 400038, China.

Purpose: To assess the role of serum pigment epithelium-derived factor (PEDF) in the occurrence and development of proteinuria and renal dysfunction and determine its relevant signaling pathway.

Methods: We analyzed serum PEDF, creatinine, the urinary albumin-to-creatinine ratio, and renal morphology of normal or streptozotocin (STZ)-induced diabetic mice, before and after treatment with PEDF. In vitro, podocytes were stimulated with PEDF under normal or high-glucose conditions; permeability was measured by the transwell assay with fluorescein isothiocyanate (FITC)-dextran; and F-actin cytoskeleton was analyzed by phalloidin staining. Read More

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http://dx.doi.org/10.1007/s11255-018-2026-3DOI Listing
December 2018
1 Read
1.293 Impact Factor

A study on the clinical application of a patented perfusion and suctioning platform and ureteral access sheath in the treatment of large ureteral stones below L4 level.

Int Urol Nephrol 2018 Dec 7. Epub 2018 Dec 7.

Department of Urology, The Affiliated Ganzhou Hospital of Nanchang University, Ganzhou, 341000, Jiangxi, China.

Purpose: The purpose of the study was to evaluate the efficacy and safety of a patented perfusion and suctioning platform and ureteral access sheath in the treatment of large ureteral stones (≥ 1.5 cm) below L4 level.

Methods: We recruited 122 patients with large ureteral stones below L4 level at our hospital from December 2014 to June 2017. Read More

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http://link.springer.com/10.1007/s11255-018-2049-9
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http://dx.doi.org/10.1007/s11255-018-2049-9DOI Listing
December 2018
1 Read

The miRNA-184 drives renal fibrosis by targeting HIF1AN in vitro and in vivo.

Authors:
Bin Chen

Int Urol Nephrol 2018 Dec 10. Epub 2018 Dec 10.

Kidney Department, Zhenhai People's Hospital of Ningbo City (Ningbo No.7 Hospital), 718 Nanerxi Road, Luotuo Subdistrict, Zhenhai, Ningbo, People's Republic of China.

Progressive renal fibrosis is the last phase of chronic kidney disease and results in renal failure. Micro-RNA has been demonstrated as important agent to drive organ fibrosis. However, the precise mechanisms are not fully understood. Read More

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http://dx.doi.org/10.1007/s11255-018-2025-4DOI Listing
December 2018
1 Read

Urine proteomic profiling in patients with nephrolithiasis and cystinuria.

Int Urol Nephrol 2018 Dec 5. Epub 2018 Dec 5.

Nephrology Division, New York University Langone Medical Center, New York, NY, USA.

Purpose: The purpose of the study was to assess the differences in the concentration and function of urinary proteins between patients with cystine stones (CYS) and healthy controls (HC). We postulated that CYS and HC groups would demonstrate different proteomic profiles.

Methods: A pilot study was performed comparing urinary proteomes of 10 patients with CYS and 10 age- and gender-matched HC, using liquid chromatography-mass spectrometry. Read More

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http://link.springer.com/10.1007/s11255-018-2044-1
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http://dx.doi.org/10.1007/s11255-018-2044-1DOI Listing
December 2018
2 Reads

The effect of chronic kidney disease on lipid metabolism.

Int Urol Nephrol 2018 Dec 5. Epub 2018 Dec 5.

Division of Nephrology, Department of Medicine, Koc University School of Medicine, 34010, Istanbul, Turkey.

The major cause of death among chronic kidney disease patients is cardiovascular diseases. Cardiovascular and kidney disease are interrelated and increase the severity of each other. Dyslipidemia is one the major causes of cardiovascular disease among chronic kidney disease patients along with diabetes and hypertension. Read More

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http://dx.doi.org/10.1007/s11255-018-2047-yDOI Listing
December 2018
1 Read

A modification with threading cannula needle-assisted 4-point suspension fixation for retroperitoneal laparoscopic pyeloplasty in children with ureteropelvic junction obstruction: a cohort study in single center.

Int Urol Nephrol 2018 Dec 5. Epub 2018 Dec 5.

Department of Urology, The Third Affiliated Hospital of Sun Yat-sen University, Tianhe Road 600, Guangzhou, 510630, Guangdong, China.

Purpose: To evaluate the effect and safety of modifying a threading cannula needle-assisted suspension fixation in retroperitoneal laparoscopic dismembered pyeloplasty (LDP) for children with congenital ureteropelvic junction obstruction (UPJO).

Methods: Between December 2012 and December 2017, 45 children (< 14 years of age) with congenital UPJO were divided into two groups. In Group A, children underwent conventional "no-suspension fixation" LDP; and in Group B, "4-point suspension fixation" LDP was performed to lower difficulties and shorten operative time. Read More

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http://dx.doi.org/10.1007/s11255-018-2048-xDOI Listing
December 2018
1 Read

Foreskin reconstruction at the time of single-stage hypospadias repair: is it a safe procedure?

Int Urol Nephrol 2018 Dec 1. Epub 2018 Dec 1.

Paediatric Urology, Evelina London Children's Hospital, London, UK.

Introduction: Foreskin reconstruction (FR) is a recognised, yet debated, option for patients undergoing single-stage hypospadias repair (HR).

Methods: We evaluated the incidence of complications after single-stage HR in our institution. This is a retrospective review of all single-stage HR. Read More

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http://link.springer.com/10.1007/s11255-018-2043-2
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http://dx.doi.org/10.1007/s11255-018-2043-2DOI Listing
December 2018
5 Reads

Penile lymphedeme: a very rare complication due to bilateral subinguinal varicocelectomy.

Int Urol Nephrol 2018 Dec 1. Epub 2018 Dec 1.

Department of Urology, School of Medicine, Gazi University, Ankara, Turkey.

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http://dx.doi.org/10.1007/s11255-018-2041-4DOI Listing
December 2018

The effects of oxytocin on penile tissues in experimental priapism model in rats.

Int Urol Nephrol 2018 Dec 4. Epub 2018 Dec 4.

Department of Urology, Faculty of Medicine, Gaziosmanpasa University, Tokat, Turkey.

Purpose: This study aimed to demonstrate the effects of oxytocin on penile tissues in ischemia-reperfusion injury developed after priapism.

Methods: Forty Wistar Albino strain male rats were divided into four groups. The control group (n = 10) was not intervened. Read More

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http://dx.doi.org/10.1007/s11255-018-2046-zDOI Listing
December 2018
1 Read
1.293 Impact Factor

How do lupus glomerulonephritis and its treatment affect the renal reserve?

Int Urol Nephrol 2018 Dec 4. Epub 2018 Dec 4.

Human Physiology Department, Instituto Universitario del Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.

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http://link.springer.com/10.1007/s11255-018-2042-3
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http://dx.doi.org/10.1007/s11255-018-2042-3DOI Listing
December 2018
3 Reads

Patterns and predictors of depression treatment among adults with chronic kidney disease and depression in ambulatory care settings in the United States.

Int Urol Nephrol 2018 Dec 4. Epub 2018 Dec 4.

Department of Pharmacy Practice and Science, College of Pharmacy, The University of Arizona, 1295 North Martin Avenue, Tucson, AZ, 85721, USA.

Purpose: One in five adults with chronic kidney disease (CKD) in the United States (US) suffers from depression. Comorbid depression in adults with CKD is associated with higher morbidity and mortality. This study used US national survey data to examine patterns and predictors of depression treatment among adults with non-dialysis-dependent CKD in the US. Read More

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http://dx.doi.org/10.1007/s11255-018-2034-3DOI Listing
December 2018

Relationship between serum sclerostin, vascular sclerostin expression and vascular calcification assessed by different methods in ESRD patients eligible for renal transplantation: a cross-sectional study.

Int Urol Nephrol 2018 Dec 4. Epub 2018 Dec 4.

Department of Nephrology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, 300 Guangzhou Road, Nanjing, 210029, Jiangsu, China.

Purpose: Vascular calcification (VC) is known to be prevalent in patients with end-stage renal disease (ESRD). Sclerostin has been identified to be involved in the cross-talk between the kidney, vasculature, and bone. The aims of the present study were to evaluate vessel sclerostin expression and its correlation with VC, as well as serum sclerostin levels. Read More

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http://link.springer.com/10.1007/s11255-018-2033-4
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http://dx.doi.org/10.1007/s11255-018-2033-4DOI Listing
December 2018
2 Reads

Evaluating the associations between urinary excretion of magnesium and that of other components in calcium stone-forming patients.

Int Urol Nephrol 2018 Dec 4. Epub 2018 Dec 4.

Urology and Nephrology Research Center, Department of Urology, Shahid Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, No. 103, 9th Boostan Street, Pasdaran Avenue, Tehran, Iran.

Purpose: Magnesium plays numerous vital roles in human's body. It is known as a protective factor in stone formation by binding to oxalate in the intestinal and urinary system, and decreasing its absorption and crystallization, respectively. Due to controversies about the association between the 24-h urine magnesium and other urine metabolites in different studies, this study was designed to find a clear answer to this question. Read More

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http://dx.doi.org/10.1007/s11255-018-2036-1DOI Listing
December 2018
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The predictive value of malnutrition for functional and cognitive status in elderly hemodialysis patients.

Int Urol Nephrol 2018 Dec 4. Epub 2018 Dec 4.

University of Medicine and Pharmacy "Gr. T. Popa" Iasi, Univeristy Street Nr. 16, 700115, Iasi, Romania.

Objective: The study aims to objectively and precisely describe, in elderly dialysis patients from a single center, the prevalence of malnutrition and severe cognitive/functional impairment and to establish the prognostic role of malnutrition assessment for patient's severe cognitive/functional status.

Design: Cross-sectional study.

Setting: A single dialysis center from north-eastern Romania. Read More

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http://link.springer.com/10.1007/s11255-018-2000-0
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http://dx.doi.org/10.1007/s11255-018-2000-0DOI Listing
December 2018
3 Reads

The other side of the coin in renal replacement therapies: the burden on caregivers.

Int Urol Nephrol 2018 Dec 4. Epub 2018 Dec 4.

Department of Internal Medicine, Division of Nephrology, School of Medicine, Mersin University, Ciftlikkoy, Yenisehir, Mersin, Turkey.

Purpose: Living with end-stage renal disease may be burdensome, not only for patients, but also for caregivers. In this study, we aim to compare caregiver burden, psychological symptoms in caregivers of peritoneal dialysis (PD), hemodialysis (HD), and transplantation (TX), and find out associated factors.

Methods: A total of 43 PD, 42 HD, 42 TX patients and a total of 127 caregivers that were actively involved with the care of their patients' dialysis were enrolled. Read More

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http://link.springer.com/10.1007/s11255-018-2029-0
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http://dx.doi.org/10.1007/s11255-018-2029-0DOI Listing
December 2018
3 Reads

Case report of inguinal metastasis of epididymal malignant mesothelioma.

Int Urol Nephrol 2018 Dec 3. Epub 2018 Dec 3.

Department of Urology, The Second Affiliated Hospital of Zhejiang University, NO. 88 Jiefang Road, 310009, Hangzhou, China.

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http://link.springer.com/10.1007/s11255-018-2045-0
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http://dx.doi.org/10.1007/s11255-018-2045-0DOI Listing
December 2018
2 Reads

Kidney fibrosis induced by various irrigation pressures in mouse models of mild and severe hydronephrosis.

Int Urol Nephrol 2018 Nov 27. Epub 2018 Nov 27.

Department of Urology, Renmin Hospital of Wuhan University, Jiefang Road 238, Wuhan, 430060, Hubei, China.

Objective: We want to study whether the degree of fibrosis in the mild and severe hydronephrosis is different, and whether the irrigation pressure will affect the fibrosis of the hydronephrosis.

Methods: Animal models of mild and severe hydronephrosis in the left kidney were established: 72 healthy C57BL/6 mice were randomly divided into nine groups (eight in each group). The N group was used as a control group, and 0 mmHg pressure perfusion was given. Read More

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http://dx.doi.org/10.1007/s11255-018-2040-5DOI Listing
November 2018
1 Read
1.293 Impact Factor

Transvesical laparoendosopic single-site surgery as a valuable option to remove eroded materials from the bladder: single-center experience and a review of the literature.

Int Urol Nephrol 2018 Nov 26. Epub 2018 Nov 26.

Department of Urology, Faculty of Medicine, University of Warmia and Mazury, Ul. Oczapowskiego 2, 10-719, Olsztyn, Poland.

Introduction: Currently, polypropylene materials are used widely for the treatment of various urogynecologic disorders. This type of treatment can be complicated, although rarely, with erosions of the polypropylene implants into the bladder or the urethra. There is no established treatment for such complications. Read More

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http://link.springer.com/10.1007/s11255-018-2039-y
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http://dx.doi.org/10.1007/s11255-018-2039-yDOI Listing
November 2018
7 Reads

Effect of pregnancy on the cholinergic responses of the bladder: role of acetylcholinesterase.

Authors:
Seham Mustafa

Int Urol Nephrol 2018 Nov 26. Epub 2018 Nov 26.

Department of Biomedical Sciences, College of Nursing, Public Authority for Applied Education & Training, P.O. Box 23167, 13092, Safat, Kuwait.

Objectives: Pregnancy is associated with many functional changes of the urinary bladder. It was reported that most of healthy women complain from urinary symptoms during pregnancy. The parasympathetic system is mainly mediating bladder emptying. Read More

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http://dx.doi.org/10.1007/s11255-018-2032-5DOI Listing
November 2018

Improved voiding function by deep brain stimulation in traumatic brain-injured animals with bladder dysfunctions.

Int Urol Nephrol 2018 Nov 24. Epub 2018 Nov 24.

School of Biomedical Engineering, College of Biomedical Engineering, Taipei Medical University, 250 Wuxing Street, Taipei, 11031, Taiwan.

Objective: Traumatic brain injury (TBI) is a global scenario with high mortality and disability, which does not have an effectual and approved therapy till now. Bladder dysfunction is a major symptom after TBI, and this study deals with the alleviation of bladder function in TBI rats, with the aid of deep brain stimulations (DBS).

Methods: TBI was induced by weight drop model (WDM) and standardized with the experimental subjects with variable heights for weight dropping. Read More

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http://link.springer.com/10.1007/s11255-018-2028-1
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http://dx.doi.org/10.1007/s11255-018-2028-1DOI Listing
November 2018
5 Reads

Feasibility of a novel technique using 3-dimensional modeling and augmented reality for access during percutaneous nephrolithotomy in two different ex-vivo models.

Int Urol Nephrol 2018 Nov 24. Epub 2018 Nov 24.

UroKlinik -Center of Excellence in Urology, Istanbul, Turkey.

Purpose: We describe a novel technique that uses mathematical calculation software, 3-dimensional (3D) modeling and augmented reality (AR) technology for access during percutaneous nephrolithotomy (PCNL) and report our first preliminary results in two different ex-vivo models.

Methods: Novel software was created in order to calculate access point and angle by using pre-operative computed tomography (CT) obtained in 50 patients. Two scans, 27 s and 10 min after injection of contrast agent, were taken in prone PCNL position. Read More

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http://link.springer.com/10.1007/s11255-018-2037-0
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http://dx.doi.org/10.1007/s11255-018-2037-0DOI Listing
November 2018
2 Reads

The phosphodiesterase type 4 inhibitor roflumilast suppresses inflammation to improve diabetic bladder dysfunction rats.

Int Urol Nephrol 2018 Nov 24. Epub 2018 Nov 24.

Department of Urology, Fourth Affiliated Hospital, China Medical University, 4 Chongshan East Road, Shenyang, Liaoning, China.

Purpose: To demonstrate that phosphodiesterase type 4 (PDE4) inhibitors could potentially treat diabetic bladder dysfunction (DBD) through modulation of the systemic inflammatory response.

Methods: In this 6-week study, 60 female Sprague-Dawley rats were divided into three groups: (i) vehicle-treated control rats; (ii) vehicle-treated streptozocin (STZ)-injected rats; and (iii) roflumilast-treated STZ-injected rats. Oral roflumilast (5 mg/kg/day) was administered during the last 4 weeks of STZ injection to induce diabetes in the test group. Read More

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http://link.springer.com/10.1007/s11255-018-2038-z
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http://dx.doi.org/10.1007/s11255-018-2038-zDOI Listing
November 2018
6 Reads

Effects of sleep disorders and sedative-hypnotic medications on health-related quality of life in dialysis patients.

Int Urol Nephrol 2018 Nov 22. Epub 2018 Nov 22.

Department of Nephrology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China.

Purpose: Sleep disorders are very common among dialysis patients, leading patients to frequently take sedative-hypnotic medications; however, the effects of sleep disorders and the use of such drugs on health-related quality of life (HRQOL) have rarely been investigated.

Methods: The Pittsburgh Sleep Quality Index and Short Form-12 were used to assess sleep quality and patient health situations, respectively. Logistic regression was employed to identify factors associated with deterioration of the mental component summary (MCS) score and the physical component summary (PCS) score. Read More

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http://dx.doi.org/10.1007/s11255-018-2018-3DOI Listing
November 2018
4 Reads

Total parenteral nutrition versus early enteral nutrition after cystectomy: a meta-analysis of postoperative outcomes.

Int Urol Nephrol 2018 Nov 21. Epub 2018 Nov 21.

Department of Urology, Changhai Hospital, Second Military Medical University, Shanghai, 200433, People's Republic of China.

Background: This study aimed to systematically summarize and analyze the current evidence regarding the effect of total parenteral nutrition (TPN) versus early enteral nutrition (EEN) on postoperative outcomes of cystectomy.

Methods: A comprehensive search of online databases was conducted to identify comparative studies on the postoperative outcomes of patients receiving TPN and EEN after cystectomy. Our subsequent meta-analysis followed the PRISMA Protocol and the Cochrane Handbook. Read More

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http://dx.doi.org/10.1007/s11255-018-2031-6DOI Listing
November 2018
1 Read

Prevalence of pulmonary hypertension in peritoneal dialysis patients: a meta-analysis.

Int Urol Nephrol 2018 Nov 19. Epub 2018 Nov 19.

Department of Nephrology and Rheumatology, Wuhan Forth Hospital; Puai Hospital Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, People's Republic of China.

Purpose: Recent epidemiological evidence indicates an association between peritoneal dialysis (PD) patients and pulmonary hypertension (PH). However, the true prevalence of PH associated with PD has not been well described. So we conducted a meta-analysis to summarize the point prevalence of PH in adults with PD. Read More

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http://dx.doi.org/10.1007/s11255-018-2017-4DOI Listing
November 2018
8 Reads

Protective effect of astaxanthin against contrast-induced acute kidney injury via SIRT1-p53 pathway in rats.

Int Urol Nephrol 2018 Nov 19. Epub 2018 Nov 19.

Institute of Cardiovascular Disease Research, Xuzhou Medical University, Xuzhou, 221002, Jiangsu, China.

Purpose: The present study was designed to further investigate the protective effect of astaxanthin (AST) on contrast-induced acute kidney injury (CI-AKI) in rats and the relationship between SIRT1-p53 pathway and astaxanthin.

Methods: 40 adult male Sprague Dawley (SD) rats were randomly divided into five groups (n = 8/group): control (CON), normal rats treated with AST (AST), CM-treated (CM), CM rats treated with isoform of nitric oxide synthase (iNOS) inhibitor (iNOS + CM), and CM rats treated with AST (AST + CM). Serum creatinine (Scr) and blood urea nitrogen (BUN) values were measured at 72 h following the procedure. Read More

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http://link.springer.com/10.1007/s11255-018-2027-2
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http://dx.doi.org/10.1007/s11255-018-2027-2DOI Listing
November 2018
1 Read

Management of anxiety and depression in haemodialysis patients: the role of non-pharmacological methods.

Int Urol Nephrol 2018 Nov 19. Epub 2018 Nov 19.

Department of Nephrology, 'Aretaieio' Hospital, National and Kapodistrian University of Athens, Athens, Greece.

Anxiety and depression in patients undergoing haemodialysis can be reduced by a variety of treatment methods, including pharmacological therapy, cognitive-behavioural therapy, regular exercise and relaxation techniques, such as Benson's relaxation method and acupressure treatment. Additionally, intradialytic exercise training programmes have a positive effect on patients' physical and psychological functioning. Moreover, social support from family and social environment, spirituality and religiosity, tele- nursing programmes and participation in network support groups frequently lead to a reduction of anxiety and depressive symptoms in these people. Read More

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http://link.springer.com/10.1007/s11255-018-2022-7
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http://dx.doi.org/10.1007/s11255-018-2022-7DOI Listing
November 2018
5 Reads

Vitamin D deficiency, endothelial function and bone biomarkers in post-kidney transplantation patients from North India.

Int Urol Nephrol 2018 Nov 19. Epub 2018 Nov 19.

Cardiology Clinical Academic Group, Molecular and Clinical Sciences Research Institute, St Georges University of London, London, UK.

Purpose: CKD patients after kidney transplantation continue to suffer from elevated CV events which may be related to low vitamin D and its adverse impact on vascular function. The prevalence of vitamin D deficiency in North Indian kidney transplantation patients and its impact on vascular and bone biomarkers is unknown which this study investigated.

Methods: Non-diabetic, stable, > 6 months post-kidney transplantation patients, not on vitamin D supplementation, were recruited after informed consent. Read More

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http://link.springer.com/10.1007/s11255-018-2014-7
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http://dx.doi.org/10.1007/s11255-018-2014-7DOI Listing
November 2018
3 Reads

The effect of overactive bladder treatment with anticholinergics on female sexual function in women: a prospective observational study.

Int Urol Nephrol 2018 Nov 17. Epub 2018 Nov 17.

Department of Urology, Okmeydani Training and Research Hospital, 34384, Sisli, Istanbul, Turkey.

Purpose: The aim of the study was to determine the effect of anticholinergics used for overactive bladder treatment on the sexual function of women.

Methods: Between January 2016 and August 2018, over 18 years old, 216 sexual active women with OAB and 165 healthy women as control group were prospectively enrolled in the study. Five different anticholinergics were used for the treatment. Read More

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http://dx.doi.org/10.1007/s11255-018-2030-7DOI Listing
November 2018
2 Reads

Influence of symptomatic pseudoaneurysms on postoperative renal function after partial nephrectomy: results of a matched pair analysis.

Int Urol Nephrol 2018 Nov 12. Epub 2018 Nov 12.

Department of Urology, University Medical Centre Mannheim, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany.

Purpose: A symptomatic pseudoaneurysm (SPA) is a rare but severe complication after partial nephrectomy (PN). Selective trans-arterial embolization (TAE) is the treatment of choice with high success rates. However, the influence of this intervention on postsurgical renal function has not been studied. Read More

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http://dx.doi.org/10.1007/s11255-018-2024-5DOI Listing
November 2018
1 Read

Urine can speed up the re-epithelialization process of prostatic urethra wounds by promoting the proliferation and migration of prostate epithelial cells.

Int Urol Nephrol 2018 Nov 7. Epub 2018 Nov 7.

Guizhou Provincial People's Hospital, Guiyang, Guizhou, China.

Objectives: The present study aimed to investigate the influence of urine on re-epithelialization in canine prostatic urethra after prostatectomy and explore possible causes.

Method: We established two groups of prostatic canine models. The first group contained urine that canines underwent the surgery by two-micron laser resection of the prostate-tangerine technique (TmLRP-TT), and no transurethral catheter was required. Read More

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http://dx.doi.org/10.1007/s11255-018-2019-2DOI Listing
November 2018

Investigations of urethral sphincter activity in mice with bladder hyperalgesia before and after drug administration of gabapentin.

Int Urol Nephrol 2018 Nov 1. Epub 2018 Nov 1.

Urology at University of California Irvine, Irvine, CA, USA.

Purpose: This study investigated the effect of gabapentin on lower urinary tract dysfunction focusing on urethral activities and cystitis-induced hyperalgesia in a mouse model of painful bladder syndrome/interstitial cystitis (PBS/IC). The electromyography (EMG) of external urethral sphincter (EUS) was difficult to obtain, but contained useful information to examine the drug effect in mice.

Methods: Female C57BL/6J mice were intraperitoneally (ip) administration with either saline or 200 mg/kg of cyclophosphamide (CYP) 48 h before experimental evaluation. Read More

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http://dx.doi.org/10.1007/s11255-018-2021-8DOI Listing
November 2018

Prophylactic effect of ethyl pyruvate on renal ischemia/reperfusion injury mediated through oxidative stress.

Int Urol Nephrol 2018 Oct 31. Epub 2018 Oct 31.

Department of Urology, New York Medical College, Valhalla, NY, 10595, USA.

Purpose: As oxidative stress (OXS) has been shown to play a primary role in renal ischemia/reperfusion injury (RIRI), we investigated whether antioxidant such as ethyl pyruvate (EPy) might effectively prevent RIRI. Possible prophylactic effects of EPy and mannitol (Mann), one of perioperative agents often used, were tested against harmful OXS in vitro.

Methods: Hydrogen peroxide (HO) was used to exert OXS on the renal proximal tubular MDCK cells. Read More

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http://dx.doi.org/10.1007/s11255-018-2020-9DOI Listing
October 2018

Effect of high-fat diet-induced obesity on the small-conductance Ca-activated K channel function affecting the contractility of rat detrusor smooth muscle.

Int Urol Nephrol 2018 Oct 25. Epub 2018 Oct 25.

Department of Urology, Fourth Affiliated Hospital, China Medical University, 4 Chongshan East Road, Shenyang, Liaoning, China.

Purpose: Obesity usually induces overactive bladder (OAB) associated with detrusor overactivity, which is related to increased contractility of the detrusor smooth muscle (DSM). Small-conductance Ca-activated K (SK) channels play a constitutive role in the regulation of DSM contractility. However, the role of SK channels in the DSM changes in obesity-related OAB is still unknown. Read More

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http://link.springer.com/10.1007/s11255-018-2016-5
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http://dx.doi.org/10.1007/s11255-018-2016-5DOI Listing
October 2018
8 Reads

Effects of parathyroidectomy on blood bone markers and heart rate variability in patients with stage 5 chronic kidney disease.

Int Urol Nephrol 2018 Dec 25;50(12):2279-2288. Epub 2018 Oct 25.

Department of Nephrology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, 210029, Jiangsu, People's Republic of China.

Purpose: Decreased heart rate variability (HRV) is closely related to abnormal cardiac autonomic nervous function, especially sympathetic hyperactivity, which intensifies the risk of cardiovascular events and sudden death. HRV parameters are lower in chronic kidney disease (CKD) and parathyroidectomy (PTX) can improve these abnormalities in severe secondary hyperparathyroidism (SHPT) patients. However, few studies have evaluated correlations between circulating bone markers and HRV in CKD patients. Read More

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http://link.springer.com/10.1007/s11255-018-1995-6
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http://dx.doi.org/10.1007/s11255-018-1995-6DOI Listing
December 2018
5 Reads

The creatinine/cystatin C ratio provides effective evaluation of muscle mass in kidney transplant recipients.

Int Urol Nephrol 2018 Oct 25. Epub 2018 Oct 25.

Department of Urology and Andrology, Kansai Medical University, Osaka, Japan.

Introduction: Measuring muscle mass is an important step in detecting sarcopenia. The evaluation of sarcopenia is also important for kidney transplant recipients. Methods for estimating muscle mass have been established using computed tomography or magnetic resonance imaging, which are considered the gold standards. Read More

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http://link.springer.com/10.1007/s11255-018-2015-6
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http://dx.doi.org/10.1007/s11255-018-2015-6DOI Listing
October 2018
7 Reads

A comparison between 2017 FAS and 2012 CKD-EPI equations: a multi-center validation study in Chinese adult population.

Int Urol Nephrol 2018 Oct 24. Epub 2018 Oct 24.

Department of Geriatric Nephrology, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029, Jiangsu, People's Republic of China.

Background: The recent guidelines recommend using the estimated glomerular filtration rate (eGFR) to evaluate renal function. There are two reported full-age-spectrum (FAS) equations in 2017, which are based on serum cystatin C concentrations with or without accompanying serum creatinine level (FAS or FAS). We compared the performance and assessed the applicability of the new FAS equation with the 2012 CKD-EPI (CKD-EPI and CKD-EPI) equation in Chinese subjects. Read More

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http://dx.doi.org/10.1007/s11255-018-1997-4DOI Listing
October 2018

Need for upper urinary tract stenting in cases of ureteral orifice injury during laser enucleation of the prostate.

Int Urol Nephrol 2018 Dec 22;50(12):2173-2177. Epub 2018 Oct 22.

Department of Urology, UT Southwestern Medical Center, Dallas, TX, USA.

Introduction: Benign prostatic hyperplasia (BPH) can be associated with marked intravesical protrusion, placing ureteral orifices at risk for injury during bladder outlet procedures.

Aim: To determine whether ureteral stenting is necessary in cases of ureteral orifice injury during laser enucleation.

Materials And Methods: Retrospective study included 465 patients with bladder outlet obstruction (IPSS > 20, Qmax < 10) secondary to BPH who were managed with thulium fiber laser (ThuFLEP) or holmium laser enucleation of the prostate (HoLEP). Read More

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http://dx.doi.org/10.1007/s11255-018-2007-6DOI Listing
December 2018
1 Read

Recovery of urinary function after robotic-assisted laparoscopic prostatectomy versus radical perineal prostatectomy for early-stage prostate cancer.

Int Urol Nephrol 2018 Dec 16;50(12):2187-2191. Epub 2018 Oct 16.

Department of Urology, Beaumont Health, Royal Oak, MI, USA.

Introduction: Robotic-assisted laparoscopic prostatectomy (RALP) has largely replaced open radical prostatectomy in many centers. Radical perineal prostatectomy (RPP) is another less invasive approach that has not been widely adopted. RPP offers excellent exposure of the urinary sphincter and bladder neck that may provide good urinary function outcomes. Read More

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http://link.springer.com/10.1007/s11255-018-2013-8
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http://dx.doi.org/10.1007/s11255-018-2013-8DOI Listing
December 2018
8 Reads

MST3 (mammalian Ste20-like protein kinase 3), a novel gene involved in ion homeostasis and renal regulation of blood pressure in spontaneous hypertensive rats.

Int Urol Nephrol 2018 Dec 16;50(12):2299-2307. Epub 2018 Oct 16.

School of Pharmacy, Tsuzuki Institute for Traditional Medicine, China Medical University, No. 91 Hsueh-Shih Road, Taichung, Taiwan.

Defective renal salt and water excretion, together with increased salt intake, frequently contributes to hypertension. Recent studies indicate that Ste20 family kinases, such as proline-alanine-rich Ste20-related kinase (SPAK) and oxidative stress-response protein 1 (OSR1), are regulators of cell volume, ion transport, and hypertension. The aim of this study was to investigate whether mammalian sterile 20-like protein kinase 3 (MST3), which is also a stress-regulated kinase, is involved in the development of hypertension. Read More

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http://link.springer.com/10.1007/s11255-018-2011-x
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http://dx.doi.org/10.1007/s11255-018-2011-xDOI Listing
December 2018
1 Read

Five microRNAs in serum as potential biomarkers for prostate cancer risk assessment and therapeutic intervention.

Int Urol Nephrol 2018 Dec 15;50(12):2193-2200. Epub 2018 Oct 15.

Beijing Municipal Key Laboratory of Child Development and Nutriomics, Capital Institute of Pediatrics, Beijing, China.

Background: Prostate cancer (PCa) is a common malignant human tumor and one of the main causes of cancer-related deaths in men. At present, prostate-specific antigen levels are widely used to diagnose PCa in the clinic, but they are not sufficient for an accurate early diagnosis or prognosis.

Methods: To identify potential molecular markers for PCa, we used real-time PCR to measure the expression levels of various microRNAs, including miR-1825, miR-484, miR-205, miR-141, and let-7b, in the serum of 72 PCa patients and 34 healthy controls. Read More

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http://dx.doi.org/10.1007/s11255-018-2009-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267169PMC
December 2018

Accidental falling in community-dwelling elderly with chronic kidney disease.

Int Urol Nephrol 2018 Oct 15. Epub 2018 Oct 15.

Department of Geriatrics, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands.

Purpose: The aim of the current study was to evaluate the association between a decreased estimated glomerular filtration rate (eGFR) and accidental falling in elderly patients who visited the day clinic of the department of geriatric medicine of the University of Medical Center Utrecht (UMCU).

Study Design: A cross-sectional analysis with people aged ≥ 65 years of the Utrecht Cardiovascular Cohort was performed. Patients were stratified into different stages of kidney disease (< 45, 45-59, and ≥ 60 ml/min per 1. Read More

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http://dx.doi.org/10.1007/s11255-018-1992-9DOI Listing
October 2018
2 Reads

A double-blind, randomized, placebo-controlled clinical trial evaluating the safety and efficacy of autologous muscle derived cells in female subjects with stress urinary incontinence.

Int Urol Nephrol 2018 Dec 15;50(12):2153-2165. Epub 2018 Oct 15.

Sunnybrook Health Sciences Centre, Toronto, ONT, Canada.

Purpose: The purpose of the study was to assess safety and efficacy of autologous muscle derived cells for urinary sphincter repair (AMDC-USR) in female subjects with predominant stress urinary incontinence.

Methods: A randomized, double-blind, multicenter trial examined intra-sphincteric injection of 150 × 10 AMDC-USR versus placebo in female subjects with stress or stress predominant, mixed urinary incontinence. AMDC-USR products were generated from vastus lateralis needle biopsies. Read More

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http://dx.doi.org/10.1007/s11255-018-2005-8DOI Listing
December 2018

Chronobiology in nephrology: the influence of circadian rhythms on renal handling of drugs and renal disease treatment.

Int Urol Nephrol 2018 Dec 15;50(12):2221-2228. Epub 2018 Oct 15.

Human Physiology Department, Instituto Universitario del Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.

Introduction: Chronobiology studies the phenomenon of rhythmicity in living organisms. The circadian rhythms are genetically determined and regulated by external synchronizers (the daylight cycle). Several biological processes involved in the pharmacokinetics and pharmacodynamics of drugs are subjected to circadian variations. Read More

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http://dx.doi.org/10.1007/s11255-018-2001-zDOI Listing
December 2018

The benefits of angiotensin-converting enzyme inhibitors/angiotensin II receptor blockers combined with calcium channel blockers on metabolic, renal, and cardiovascular outcomes in hypertensive patients: a meta-analysis.

Int Urol Nephrol 2018 Dec 15;50(12):2261-2278. Epub 2018 Oct 15.

Division of Nephrology, Department of Medicine, Faculty of Medicine, King Chulalongkorn Memorial Hospital, Chulalongkorn University, Bangkok, 10330, Thailand.

Background: The prevalence of hypertension and its associated complications are markedly growing. Most patients need more than one drug to achieve blood pressure (BP) target. However, most guidelines only focus on the first-line treatment. Read More

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http://link.springer.com/10.1007/s11255-018-1991-x
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http://dx.doi.org/10.1007/s11255-018-1991-xDOI Listing
December 2018
3 Reads

The influence of chronic kidney disease on the duration of hospitalisation and transfusion rate after elective hip and knee arthroplasty.

Int Urol Nephrol 2018 Oct 15. Epub 2018 Oct 15.

Klinik für Orthopädie und Unfallchirurgie, Universitätsklinikum Essen, Universität Duisburg-Essen, Hufelandstrasse 55, 45147, Essen, Germany.

Purpose: Elective hip or knee replacement is an optimal, standardised orthopaedic surgical procedure. The influence of chronic kidney disease, defined as an estimated glomerular filtration rate (eGFR) of 15-45 ml/min/1.73 m body surface area (BSA) (KDIGO stage G3a-G4), on the duration of hospitalisation, perioperative decrease in haemoglobin (Hb) levels, and transfusion rates after orthopaedic procedures has not been fully clarified. Read More

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http://dx.doi.org/10.1007/s11255-018-2008-5DOI Listing
October 2018

Significant association of anti-platelet factor 4/heparin antibody with cardiovascular disease in hemodialysis patients: a longitudinal 7-year study.

Int Urol Nephrol 2018 Dec 15;50(12):2289-2297. Epub 2018 Oct 15.

Department of Nephrology, Tainan Sinlau Hospital, No. 57, 1 Sec., Dongmen Rd, Tainan, Taiwan.

Background: Hemodialysis patients have a high incidence of anti-platelet factor 4/heparin antibody (PF4-H Ab) and are at a high risk of cardiovascular disease. This study determines the association between PF4-H Ab and cardiovascular events including coronary artery disease (CAD), ischemic stroke (IS), and native arteriovenous fistula thrombosis (AVFT), in a longitudinal 7-year follow-up.

Patients And Methods: 84 hemodialysis patients were enrolled. Read More

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http://link.springer.com/10.1007/s11255-018-2002-y
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http://dx.doi.org/10.1007/s11255-018-2002-yDOI Listing
December 2018
6 Reads