6,037 results match your criteria International urology and nephrology[Journal]


ALLN-177, oral enzyme therapy for hyperoxaluria.

Int Urol Nephrol 2019 Feb 19. Epub 2019 Feb 19.

Feinberg School of Medicine, Northwestern University, Ann & Robert H. Lurie Children's Hospital of Chicago, 225 E Chicago Avenue, Chicago, IL, 60611, USA.

Purpose: To evaluate the potential of ALLN-177, an orally administered, oxalate-specific enzyme therapy to reduce urine oxalate (UOx) excretion in patients with secondary hyperoxaluria.

Methods: Sixteen male and female subjects with both hyperoxaluria and a kidney stone history were enrolled in an open-label study. Subjects continued their usual diets and therapies. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11255-019-02098-1DOI Listing
February 2019

More lymph node dissection improves survival in patients with newly diagnosed lymph node-positive penile cancer.

Int Urol Nephrol 2019 Feb 13. Epub 2019 Feb 13.

Department of Urology, Shanghai Tenth People's Hospital, Tongji University, No. 301, Yanchang Road, Jing'an District, Shanghai, 200072, China.

Purpose: For patients with lymph node-positive (LN+) penile cancer, the optimal extent of lymph node dissection (LND) is currently not established. We aimed to reveal the potential association between survival and the number of LND in patients with newly diagnosed LN + penile cancer.

Methods: Patients with LN + penile cancer diagnosed between 2004 and 2015 were identified using the SEER database. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11255-019-02084-7DOI Listing
February 2019

CT characteristics predict the response to everolimus or sirolimus of renal angiomyolipomas in patients with tuberous sclerosis complex.

Int Urol Nephrol 2019 Feb 11. Epub 2019 Feb 11.

Department of Urology, Xiangya Hospital, Central South University, No. 87 Xiangya Road, Changsha, 410008, Hunan, China.

Objective: To investigate factors influencing the volume response of everolimus and sirolimus in tuberous sclerosis complex (TSC) associated-angiomyolipomas (AML).

Methods: A retrospective analysis of 30 cases of TSC-AML treated by mTOR inhibitors (everolimus 18 cases, and sirolimus 12 cases) between April 2014 and November 2017 at our center was carried out. Epidemiological data, therapeutic response and influence factors were reviewed and analyzed. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s11255-019-02093-6
Publisher Site
http://dx.doi.org/10.1007/s11255-019-02093-6DOI Listing
February 2019
2 Reads

SAMD5 mRNA was overexpressed in prostate cancer and can predict biochemical recurrence after radical prostatectomy.

Int Urol Nephrol 2019 Feb 9. Epub 2019 Feb 9.

Department of Urology, National Key Clinical Specialty of Urology, The Second Hospital of Tianjin Medical University, Tianjin, 300211, China.

Purpose: To identify a novel biomarker that can predict biochemical recurrence (BCR) after radical prostatectomy.

Methods: The gene expression profile of SAMD5 in prostate cancer was explored based on the oncomine database and The Cancer Genomic Atlas (TCGA). The follow-up information and clinical pathologic variables were extracted from the following cohort study: TCGA_prostate carcinoma. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11255-019-02096-3DOI Listing
February 2019

Vitamin D supplementation for the improvement of vascular function in patients with chronic kidney disease: a meta-analysis of randomized controlled trials.

Int Urol Nephrol 2019 Feb 8. Epub 2019 Feb 8.

Sichuan 2nd Hospital of Traditional Chinese Medicine, Chengdu, Sichuan, China.

Background: The efficacy of vitamin D on vascular function remains controversial in chronic kidney disease (CKD) patients. The aim of the present work was to perform a meta-analysis of randomized controlled trials to evaluate the efficacy of vitamin D on vascular function in CKD patients.

Methods: We searched Medline, the Cochrane Central Register of Controlled Trials, Embase, the Science Citation Index, and clinical trial registries for randomized controlled trials comparing vitamin D with a placebo in CKD patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11255-019-02088-3DOI Listing
February 2019

Ovarian reserve in an Egyptian cohort with end-stage kidney disease on hemodialysis and after successful kidney transplantation: a prospective study.

Int Urol Nephrol 2019 Feb 8. Epub 2019 Feb 8.

Urology Department, Cairo University School of Medicine, Cairo University, Cairo, Egypt.

Background: Women with chronic kidney disease commonly have menstrual irregularities and fertility abnormalities. Antimüllerian hormone (AMH) and antral follicle count (AFC) are well-recognized indicators of ovarian reserve.

Aims: To assess AMH level and total AFC in women who are on hemodialysis and after successful kidney transplantation (KTx). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11255-019-02089-2DOI Listing
February 2019

Spironolactone alleviates diabetic nephropathy through promoting autophagy in podocytes.

Int Urol Nephrol 2019 Feb 8. Epub 2019 Feb 8.

Department of Nephrology, First Hospital of Jilin University, 71 Xinmin Street, Changchun, 130021, Jilin, People's Republic of China.

Purpose: Podocytes are terminally differentiated cells lining the Bowman's capsule. Podocytes are critical for the proper glomerular filtration barrier function. At the same time, autophagy is crucial for maintaining podocyte homeostasis and insufficient autophagy could cause podocyte loss and proteinuria that is commonly observed in diabetic nephropathy (DN). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11255-019-02074-9DOI Listing
February 2019
1 Read

Which antimuscarinic agents used in the treatment of overactive bladder increase heart rate? a prospective randomized clinical trial.

Int Urol Nephrol 2019 Feb 6. Epub 2019 Feb 6.

Department of Urology, Bagcilar Training and Research Hospital, University of Health Sciences, Istanbul, Turkey.

Purpose: To compare the heart rate increase side effect of different antimuscarinic drugs used in overactive bladder (OAB).

Methods: Overall 341 patients were consecutively randomized to take seven different antimuscarinic drugs between January 2014 and June 2016 at three institutions, and 250 patients who completed the follow-up visits were accepted into this study. Ninety-one patients who never came to visits were excluded. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11255-019-02090-9DOI Listing
February 2019
3 Reads

Long term oncologic outcome in patients with bladder cancer after radical cystectomy: Impact of carcinoma in situ in the era of neoadjuvant chemotherapy.

Int Urol Nephrol 2019 Jan 31. Epub 2019 Jan 31.

Institute of Urology, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA.

Purpose: To assess the impact of carcinoma in situ (CIS) on oncologic outcomes in patients who underwent radical cystectomy, with a focus on those who received neoadjuvant chemotherapy (NAC) including patients with down-staging to ≤ pT1cancer after chemotherapy.

Materials And Methods: All patients who underwent radical cystectomy for urothelial cancer with curative intent from 1985 to 2011 were included. The impact of CIS on recurrence free and overall survival (OS) was assessed in the whole cohort and a subgroup who received NAC as well as those with response to chemotherapy and down-staging to ≤ pT1. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11255-019-02087-4DOI Listing
January 2019
1.293 Impact Factor

Factors determining the sperm retrieval rate in fresh versus salvage micro-TESE: a comparative cohort study.

Int Urol Nephrol 2019 Jan 30. Epub 2019 Jan 30.

Department of Andrology & STDs, Kasr AlAiny Faculty of medicine, Cairo University, Giza, Egypt.

Purpose: We studied prospectively the role of FSH, testis volume, age, duration of infertility, hormonal therapy, varicocelectomy and testicular histopathology in determining the sperm retrieval rate (SRR) in fresh versus salvage micro-TESE.

Methods: Our study analysed retrospectively the prospectively maintained database of 330 NOA patients who underwent micro-TESE either 1st or 2nd or 3rd timers from January 2017 to August 2018 from the Andrology Clinic of a specialized IVF centre. They were divided equally into 3 groups, group (1) were 1st timers, group (2) were 2nd timers and group (3) were 3rd timers, respectively. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11255-019-02086-5DOI Listing
January 2019
1 Read

Functional capacity, renal function and vitamin D in community-dwelling oldest old.

Int Urol Nephrol 2019 Jan 30. Epub 2019 Jan 30.

Division of Geriatrics and Gerontology, School of Medicine, Federal University of São Paulo, Unifesp, Rua Professor Francisco de Castro, 105, São Paulo, SP, 04020-050, Brazil.

Purpose: The aim of this study was to evaluate the association between the decline in estimated glomerular filtration rate (eGFR) and serum 25(OH)D with the physical and mental functional capacity of elderly individuals aged 80 years or older.

Methods: We evaluated the functional capacity in its multidomain aspects: Geriatric Depression Scale (GDS), Instrumental Activities of Daily Living (IADL), Mental State Mini-Exam (MMSE), Verbal Fluency Test (VF), handgrip strength and time to sit and rise from a chair five times, combined creatinine and cystatin C-based eGFR and 25(OH)D levels in 205 independent asymptomatic and community-dwelling elderly subjects in a cross-sectional study.

Results: Every 1 year of life, there was reduction of about 10% chance of adequate performance in functional capacity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11255-019-02081-wDOI Listing
January 2019
1 Read

Relationship between cFGF23/Klotho ratio and phosphate levels in patients with chronic kidney disease.

Int Urol Nephrol 2019 Jan 28. Epub 2019 Jan 28.

The People's Hospital of Fujian Province, Fuzhou, 350004, Fujian, People's Republic of China.

Purpose: To characterize the relationship between the cFGF23/Klotho ratio and phosphate level in patients with chronic kidney disease (CKD).

Methods: A total of 152 patients with CKD stage 3-5 (CKD stage 3: n = 74; CKD stage 4: n = 60; CKD stage 5: n = 18) were included in the study. Thirty healthy volunteers served as controls. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11255-019-02079-4DOI Listing
January 2019
1 Read
1.293 Impact Factor

Associations of vitamin K status with mortality and cardiovascular events in peritoneal dialysis patients.

Int Urol Nephrol 2019 Jan 28. Epub 2019 Jan 28.

Department of Nephrology, the 2nd Affiliated Hospital of Guangzhou Medical University, Guangdong, People's Republic of China.

Purpose: Vitamin K deficiency, expressed by a high level of desphospho-uncarboxylated matrix GLA protein (dp-ucMGP), is highly prevalent in dialysis patients. However, the predictive ability of the vitamin K status remains unclear in continuous ambulatory peritoneal dialysis (CAPD) patients.

Methods: 158 prevalent CAPD patients with a median level of dp-ucMGP of 1093 (752, 1485) pmol/L were enrolled. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11255-019-02080-xDOI Listing
January 2019
1 Read

Socioeconomic status and mortality among dialysis patients: a systematic review and meta-analysis.

Int Urol Nephrol 2019 Jan 28. Epub 2019 Jan 28.

Kidney Research Lab, Division of Nephrology, West China School of Medicine, West China Hospital of Sichuan University, Chengdu, 610041, China.

Background: The reported association between individual indicators of socioeconomic status (SES) and mortality in dialysis patients was inconsistent in previous studies. We performed a meta-analysis to identify the association between SES and mortality of dialysis population.

Methods: The meta-analysis was conducted in accordance with MOOSE guidelines. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11255-019-02078-5DOI Listing
January 2019

Peritoneal dialysis can alleviate the clinical course of hungry bone syndrome after parathyroidectomy in dialysis patients with secondary hyperparathyroidism.

Int Urol Nephrol 2019 Jan 28. Epub 2019 Jan 28.

Department of Nephrology, The First Affiliated Hospital of Nanjing Medical University, 300# Guangzhou Road, Nanjing, 210029, Jiangsu Province, China.

Purpose: It is unclear whether clinical courses of hungry bone syndrome (HBS) after parathyroidectomy (PTX) in peritoneal dialysis (PD) and hemodialysis (HD) patients are different. The present study aimed to investigate the possible differences of postoperative hypocalcemia and hyperkalemia between PD and HD patients.

Methods: We performed retrospectively 29 PD patients as the PD group and 169 HD patients as the HD group undergoing successful total PTX with autotransplantation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11255-019-02076-7DOI Listing
January 2019
1 Read

Increased risk of new-onset type 2 diabetes in people with chronic kidney disease.

Int Urol Nephrol 2019 Jan 28. Epub 2019 Jan 28.

Graduate Institute of Clinical Medical Science, China Medical University College of Medicine, Taichung, Taiwan.

Purpose: This study investigated whether people with chronic kidney disease (CKD) are at the risk of new-onset type 2 diabetes.

Methods: A cohort comprising 16,624 people with CKD, and an age- and sex-matched control cohort of 66,496 persons without any clinical kidney disease were identified from the Taiwan National Health Insurance Database during the period of 2000-2010. Both cohorts were followed up to 2011 to evaluate the incidence and hazard ratio (HR) of developing new-onset type 2 diabetes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11255-019-02075-8DOI Listing
January 2019

Whole mount histopathological correlation with prostate MRI in Grade I and II prostatectomy patients.

Int Urol Nephrol 2019 Jan 22. Epub 2019 Jan 22.

Division of Urologic Oncology, Urology Institute, University Hospitals Cleveland Medical Center, 11100 Euclid Avenue, Cleveland, OH, 44106, USA.

Background: Multiparametric magnetic resonance imaging (mpMRI) is increasingly used in detection and surveillance of prostate cancer. However, the co-localization of lower grade lesions between mpMRI and histopathologic specimen has not been well established.

Objective: We aim to determine the factors on final histopathological exam that correlate to tumor visibility for Grade I and II disease on mpMRI. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11255-019-02083-8DOI Listing
January 2019
1.293 Impact Factor

Correction to: Basiliximab versus rabbit antithymocyte globulin as induction therapy for living-related renal transplantation: a single-center experience.

Int Urol Nephrol 2019 Jan 21. Epub 2019 Jan 21.

Kidney Disease Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, Qingchun Road 79, Hangzhou, 310003, China.

In the original publication, incorrect grant number was included in the Acknowledgements text as 'This study (article) was supported by Natural Science Foundation Y16H050011 of Zhejiang Province, China'. The correct acknowledgement section is given here. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11255-019-02082-9DOI Listing
January 2019

Laparoendoscopic single-site nephrectomy with the aid of intraabdominal retractors.

Int Urol Nephrol 2019 Jan 14. Epub 2019 Jan 14.

Department of Urology, Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, Jiangsu Provincial Hospital of Traditional Chinese Medicine, 155 Han zhong Road, Nanjing, 210029, China.

Objectives: To evaluate the feasibility and clinical efficacy of a novel intraabdominal retractor device in laparoendoscopic single-site nephrectomy(LESS-N).

Methods: Between February 2012 and February 2017, 98 patients underwent LESS-N in our institution, including 38 patients with benign renal disease and 60 patients with malignant renal disease. 39 were performed conventional LESS-N(C-LESS-N) and 59 were performed intraabdominal retractor-assisted LESS-N(IAR-LESS-N). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11255-019-02077-6DOI Listing
January 2019

Organ-sparing procedures in GU cancer: part 1-organ-sparing procedures in renal and adrenal tumors: a systematic review.

Int Urol Nephrol 2019 Jan 8. Epub 2019 Jan 8.

Department of Urology, Baylor College of Medicine and Michael E. De Bakey VA Medical Center, Houston, TX, USA.

Purpose: Organ-sparing surgery (OSS) for the kidney and adrenals has emerged as the need for preservation of function is paramount in patients with poor functional reserve. As reports increasingly showed that oncological outcomes were equivalent to radical excision, elective OSS became a viable alternative in patients with otherwise normal reserve. In this review, we summarize the current knowledge of OSS for adrenal and renal tumors. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11255-018-02070-5DOI Listing
January 2019
1 Read

The impact of antihypertensive pharmacotherapy on interplay between protein-bound uremic toxin (indoxyl sulfate) and markers of inflammation in patients with chronic kidney disease.

Int Urol Nephrol 2019 Jan 7. Epub 2019 Jan 7.

Department of Pharmacodynamics, Medical University of Bialystok, Mickiewicza 2C, 15-222, Białystok, Poland.

Purpose: Indoxyl sulfate (IS) is one of the most potent uremic toxins involved in chronic kidney disease (CKD) progression, induction of inflammation, oxidative stress, and cardiovascular diseases occurrence. It is proved that hypertension is a common CVD complication and a major death risk factor as well as contributes for decline in a renal function. The aim of our study was to investigate how implementing of antihypertensive therapy impact IS concentrations and the associations between IS and markers of renal function, inflammation and oxidative stress. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11255-018-02064-3DOI Listing
January 2019

THSD7A as a marker for paraneoplastic membranous nephropathy.

Int Urol Nephrol 2019 Feb 3;51(2):371-373. Epub 2019 Jan 3.

Department of Medical Image, HeBei General Hospital, Shijiazhuang, People's Republic of China.

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s11255-018-02068-z
Publisher Site
http://dx.doi.org/10.1007/s11255-018-02068-zDOI Listing
February 2019
6 Reads

Successful endovascular treatment of chronic renal artery occlusion: a preliminary retrospective case series including 15 patients.

Int Urol Nephrol 2019 Feb 3;51(2):285-291. Epub 2019 Jan 3.

Department of Interventional Radiology and Vascular Surgery, Peking University First Hospital, 8 Xishiku St, Beijing, 100034, People's Republic of China.

Purpose: To evaluate in a retrospective, single-center, case series if percutaneous transluminal renal angioplasty/stenting of chronic renal artery occlusion is beneficial to renal function and blood pressure control, which remains controversial.

Methods: Data from 15 consecutive patients with renal artery stump who underwent successful percutaneous transluminal renal angioplasty/stenting only for unilateral chronic renal artery occlusion at our center from January 2007 to February 2018 and completed follow-up were retrospectively evaluated. Of the 15 patients, 14 (93. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11255-018-02067-0DOI Listing
February 2019

Association of neutrophil-to-lymphocyte ratio with early renal dysfunction and albuminuria among diabetic patients.

Int Urol Nephrol 2019 Jan 3. Epub 2019 Jan 3.

Department of Community Medicine, Ehime University Graduate School of Medicine, Toon-city, 791-0295, Japan.

Purpose: Neutrophil-to-lymphocyte ratio (NLR) was widely studied as a prognostic marker in various medical and surgical specialties, but its significance in diabetic kidney disease is not yet established.

Methods: The subjects comprised 199 men aged 73 ± 11 (mean ± standard deviation) years and 187 women aged 77 ± 10 years from a rural hospital. We examined the relationship between NLR calculated by analyzing differential leukocyte count in complete blood picture and renal function evaluated by estimated glomerular filtration rate (eGFR) using the Modification of Diet in Renal Disease Study Group equation and urinary albumin excretion (UAE). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11255-018-02065-2DOI Listing
January 2019
2 Reads

Reinforcement of the Triple D score with simple addition of the intrarenal location for the prediction of the stone-free rate after shockwave lithotripsy for renal stones 10-20 mm in diameter.

Int Urol Nephrol 2019 Feb 2;51(2):239-245. Epub 2019 Jan 2.

Department of Urology, Yamagata University Faculty of Medicine, 2-2-2 Iida-nishi, Yamagata, 998-9585, Japan.

Purpose: We investigated the clinical efficacy of the Triple D score (TrD-S) on stone-free rate (SFR) prediction following shockwave lithotripsy (SWL) for renal stones 10-20 mm in diameter and modified the scoring system to improve outcome prediction.

Methods: We retrospectively examined clinical data from the medical records of 226 consecutive patients who underwent SWL for 10-20 mm kidney stones. The TrD-S was calculated according to the cutoffs of < 150 mm for stone volume, < 600 Hounsfield unit for stone density, and < 12 cm for skin-to-stone distance on computed tomography. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11255-018-02066-1DOI Listing
February 2019

Effects of hydrogen sulfide on acetaminophen-induced acute renal toxicity in rats.

Int Urol Nephrol 2019 Jan 2. Epub 2019 Jan 2.

Department of Biology, Faculty of Science and Literature, Kutahya Dumlupinar University, Kutahya, Turkey.

Introduction And Aim: Hydrogen sulfide (HS) is an endogenously produced gas-structure mediator. It is proposed to have antioxidant, anti-inflammatory and antiapoptotic effects. Acetaminophen (N-acetyl-P-aminophenol; APAP) is an antipyretic and analgesic medication known as paracetamol. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11255-018-2053-0DOI Listing
January 2019
2 Reads

Correction to: Disparities in early mortality among chronic kidney disease patients who transition to peritoneal dialysis and hemodialysis with and without catheters.

Int Urol Nephrol 2019 Feb;51(2):375-376

Department of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, CA, USA.

In the original publication, age stratified mortality rates were incorrectly added in Fig. 2. The correct Fig. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s11255-018-2060-1
Publisher Site
http://dx.doi.org/10.1007/s11255-018-2060-1DOI Listing
February 2019
1 Read
1.293 Impact Factor

Evolution of protein-bound uremic toxins indoxyl sulphate and p-cresyl sulphate in acute kidney injury.

Int Urol Nephrol 2019 Feb 2;51(2):293-302. Epub 2019 Jan 2.

Nephrology Division, Ghent University Hospital, Corneel Heymanslaan 10, 9000, Ghent, Belgium.

Background: There is a gradual increase in serum concentrations of protein-bound colon-derived uremic toxins indoxyl sulphate (IxS) and p-cresyl sulphate (pCS) as chronic kidney disease (CKD) progresses. In acute kidney injury (AKI), up till now, the retention pattern has not been studied.

Methods: In this study, 194 adult patients admitted with sepsis to the intensive care unit were included. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s11255-018-2056-x
Publisher Site
http://dx.doi.org/10.1007/s11255-018-2056-xDOI Listing
February 2019
6 Reads

Association of the blood urea nitrogen-to-left ventricular ejection fraction ratio with contrast-induced nephropathy in patients with acute coronary syndrome who underwent percutaneous coronary intervention.

Int Urol Nephrol 2019 Jan 2. Epub 2019 Jan 2.

Department of Cardiology, Izmir Katip Celebi University, Ataturk Training and Research Hospital, Izmir, Turkey.

Aim: We investigated the predictive value of the blood urea nitrogen-to-left ventricular ejection fraction ratio (BUNEFr) to evaluate the risk of contrast-induced nephropathy (CIN) in acute coronary syndrome (ACS) patients who were treated with percutaneous coronary intervention (PCI).

Methods: A total of 1010 ACS patients undergoing PCI were included in this study. The serum creatinine level was measured before and within 48-72 h of contrast medium administration. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11255-018-2052-1DOI Listing
January 2019
1 Read

Current epidemiology and practice patterns in prevention and treatment of PD-related infections in Poland.

Int Urol Nephrol 2019 Feb 2;51(2):335-341. Epub 2019 Jan 2.

Clinical Microbiology Laboratory, University Hospital of Gdańsk, Gdańsk, Poland.

Background: Peritoneal dialysis (PD) related infections are associated with technique failure and mortality. The aim of this multicentre study was to examine epidemiology, treatment and outcomes of PD-related infections in Poland as well as practice patterns for prevention of these complications in the context of current ISPD recommendations.

Methods: A survey on PD practices in relation to infectious complications was conducted in 11 large Polish PD centres. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11255-018-2057-9DOI Listing
February 2019

Comparison of renoprotective effects of febuxostat and allopurinol in hyperuricemic patients with chronic kidney disease.

Int Urol Nephrol 2019 Jan 2. Epub 2019 Jan 2.

Department of Internal Medicine, Dongguk University Ilsan Hospital, Goyang, South Korea.

Purpose: This study aimed to compare the renoprotective effect between febuxostat and allopurinol in hyperuricemic patients with chronic kidney disease (CKD), about which limited data are available.

Methods: 141 patients with stage 3 CKD and hyperuricemia were followed from June 2005 to April 2018. Thirty patients received febuxostat, 40 allopurinol and 71 conventional CKD management only (control group). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11255-018-2051-2DOI Listing
January 2019
1 Read

Aspirin attenuates podocyte injury in diabetic rats through overriding cyclooxygenase-2-mediated dysregulation of LDL receptor pathway.

Int Urol Nephrol 2019 Jan 2. Epub 2019 Jan 2.

Institute of Nephrology, Zhong Da Hospital, Medical School of Southeast University, NO. 87, Ding Jia Qiao Road, Nang Jing, 210009, Jiang Su, China.

Aim: This study aimed to investigate the effects of aspirin on podocyte injury and its underlying mechanisms in diabetic nephropathy (DN).

Methods: Eight-week-old male Sprague-Dawley rats were divided into three groups: non-diabetic rats (Control), streptozotocin-induced diabetic rats (DM), and diabetic rats treated with aspirin (DM + Aspirin) for 12 weeks. Intracellular lipid accumulation was evaluated by Oil Red O staining and quantitative free cholesterol assays. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s11255-018-2059-7
Publisher Site
http://dx.doi.org/10.1007/s11255-018-2059-7DOI Listing
January 2019
4 Reads

Usefulness of frailty evaluation for handling chronic kidney disease elderly patients: a review and original proposal.

Int Urol Nephrol 2019 Jan 2. Epub 2019 Jan 2.

Physiology Department, Instituto Universitario del Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.

There is interdependence between chronic kidney disease (CKD) and ageing whereby CKD makes ageing more accelerated and pronounced, whereas ageing accelerates chronic nephropathy's progression. Frailty status catalyzes this spiral, with renal and systemic negative consequences, and this condition can currently be documented by applying already validated clinical scores (frailty phenotype) or physical test (gate speed). Although, nephroprevention strategies are similar between young adult and senior CKD patients, standard targets should be adequate to very old and frail elderly individuals. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s11255-018-2061-0
Publisher Site
http://dx.doi.org/10.1007/s11255-018-2061-0DOI Listing
January 2019
3 Reads

The safety of extracorporeal shock wave lithotripsy: an undervalued issue.

Int Urol Nephrol 2019 Jan 2. Epub 2019 Jan 2.

Department of Urology, University of Modena and Reggio Emilia, Via del Pozzo 71, 41100, Modena, Italy.

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s11255-018-2063-y
Publisher Site
http://dx.doi.org/10.1007/s11255-018-2063-yDOI Listing
January 2019
1 Read

Impact of serum hepcidin and inflammatory markers on resistance to erythropoiesis-stimulating therapy in haemodialysis patients.

Int Urol Nephrol 2019 Feb 2;51(2):325-334. Epub 2019 Jan 2.

Hematology Unit, Department of Clinical Pathology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.

Purpose: Anaemia and resistance to erythropoiesis-stimulating agents (ESAs) are common complications in haemodialysis (HD) patients. We investigated the role of hepcidin in the development of anaemia and ESA resistance/hyporesponsiveness and its relation to the plasma levels of the inflammatory markers interleukin 6 (IL-6) and high-sensitivity C-reactive protein (hsCRP).

Methods: This study included 60 maintenance HD patients attending Ain Shams University Hospital and 30 age- and sex-matched healthy subjects as a control group. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11255-018-2062-zDOI Listing
February 2019

Relationship between plasma levels of sclerostin, calcium-phosphate disturbances, established markers of bone turnover, and inflammation in haemodialysis patients.

Int Urol Nephrol 2018 Dec 24. Epub 2018 Dec 24.

Pathophysiology Unit, Department of Pathophysiology, Medical University of Silesia, Katowice, Poland.

Purpose: Data concerning the relation between increased levels of circulating sclerostin (a physiological inhibitor of bone formation) and bone turnover in patients with chronic renal failure (CRF) are limited. Therefore, the aim of this study was to evaluate associations between plasma sclerostin levels and calcium-phosphate disturbances, markers of bone turnover as well as inflammation in haemodialysis (HD) patients.

Methods: In plasma samples obtained in 150 stable HD patients (92 men) aged 40-70 years, levels of sclerostin, fibroblast growth factor (cFGF23), osteocalcin, the N-terminal propeptide of type I procollagen, C-terminal telopeptide of the alpha chain of type I collagen (β-CTx), and inflammatory markers (IL-6 and TNF-α) in addition to routine parameters (calcium, phosphorus, parathyroid hormone-iPTH, 25-OH-D, alkaline phosphatase) were measured. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11255-018-2050-3DOI Listing
December 2018
4 Reads
1.293 Impact Factor

Low serum folic acid can be a potential independent risk factor for erectile dysfunction: a prospective case-control study.

Int Urol Nephrol 2019 Feb 13;51(2):223-229. Epub 2018 Dec 13.

Andrology & STDs Department, Kasr Al-Ainy Faculty of Medicine, Cairo University, Giza, Egypt.

Purpose: The purpose of the study was to compare serum level of folic acid (FA) in patients with erectile dysfunction (ED) versus healthy controls and to assess its correlation with other well-known confounders for ED.

Methods: Our prospective study compared FA in 60 patients with ED versus 30 healthy controls. Patients were excluded if they had any hormonal disorders, Peyronie's disease, or decompensated systemic illnesses. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s11255-018-2055-y
Publisher Site
http://dx.doi.org/10.1007/s11255-018-2055-yDOI Listing
February 2019
7 Reads

Vaginoplasty and creating labia minora in children with disorders of sex development.

Int Urol Nephrol 2018 Dec 13. Epub 2018 Dec 13.

Department of Visceral Surgery, Faculty of Medicine, Children's Hospital Canastel, University of Oran, Oran, Algeria.

Purpose: To report current results of vaginoplasty using the mucosa of the prepuce, and creating labia minora by penile skin in children with disorders of sex development (DSD).

Methods: In 10 years, we have performed 22 vaginoplasties using the described technique of vaginoplasty, 21 patients with 46, XX DSD and 1 ovotesticular DSD. The assessment of the results of this technique of vaginoplasty was undertaken in several stages: (a) The evaluation of the cosmetic result. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11255-018-2058-8DOI Listing
December 2018
8 Reads
1.293 Impact Factor

Mini-percutaneous nephrolithotomy for pediatric complex renal calculus disease: one-stage or two-stage?

Int Urol Nephrol 2019 Feb 12;51(2):201-206. Epub 2018 Dec 12.

Department of Urology, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.

Objectives: To compare two different treatment strategies, one-stage and two-stage multi-tract mini-percutaneous nephrolithotomy (mt-mPCNL), for pediatric complex renal calculus disease.

Methods: Between the period of July 2016 and July 2018, a total of 36 children aged 15 years and younger, with complex renal calculi disease, who underwent total ultrasound-guided mt-mPCNL by a single experienced urologist were enrolled in our study. All patients were assigned either to Group 1 (n = 18) who received one-stage mt-mPCNL or Group 2 (n = 18) who received planned two-stage mt-mPCNL. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s11255-018-2054-z
Publisher Site
http://dx.doi.org/10.1007/s11255-018-2054-zDOI Listing
February 2019
1 Read

Increased levels of serum pigment epithelium-derived factor aggravate proteinuria via induction of podocyte actin rearrangement.

Int Urol Nephrol 2019 Feb 7;51(2):359-367. Epub 2018 Dec 7.

Department of Endocrinology, Southwest Hospital, Third Military Medical University (Army Medical University), 29 Gaotanyan Street, Chongqing, 400038, China.

Purpose: To assess the role of serum pigment epithelium-derived factor (PEDF) in the occurrence and development of proteinuria and renal dysfunction and determine its relevant signaling pathway.

Methods: We analyzed serum PEDF, creatinine, the urinary albumin-to-creatinine ratio, and renal morphology of normal or streptozotocin (STZ)-induced diabetic mice, before and after treatment with PEDF. In vitro, podocytes were stimulated with PEDF under normal or high-glucose conditions; permeability was measured by the transwell assay with fluorescein isothiocyanate (FITC)-dextran; and F-actin cytoskeleton was analyzed by phalloidin staining. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11255-018-2026-3DOI Listing
February 2019
1 Read
1.293 Impact Factor

A study on the clinical application of a patented perfusion and suctioning platform and ureteral access sheath in the treatment of large ureteral stones below L4 level.

Int Urol Nephrol 2019 Feb 7;51(2):207-213. Epub 2018 Dec 7.

Department of Urology, The Affiliated Ganzhou Hospital of Nanchang University, Ganzhou, 341000, Jiangxi, China.

Purpose: The purpose of the study was to evaluate the efficacy and safety of a patented perfusion and suctioning platform and ureteral access sheath in the treatment of large ureteral stones (≥ 1.5 cm) below L4 level.

Methods: We recruited 122 patients with large ureteral stones below L4 level at our hospital from December 2014 to June 2017. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s11255-018-2049-9
Publisher Site
http://dx.doi.org/10.1007/s11255-018-2049-9DOI Listing
February 2019
7 Reads

The miRNA-184 drives renal fibrosis by targeting HIF1AN in vitro and in vivo.

Authors:
Bin Chen

Int Urol Nephrol 2018 Dec 10. Epub 2018 Dec 10.

Kidney Department, Zhenhai People's Hospital of Ningbo City (Ningbo No.7 Hospital), 718 Nanerxi Road, Luotuo Subdistrict, Zhenhai, Ningbo, People's Republic of China.

Progressive renal fibrosis is the last phase of chronic kidney disease and results in renal failure. Micro-RNA has been demonstrated as important agent to drive organ fibrosis. However, the precise mechanisms are not fully understood. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11255-018-2025-4DOI Listing
December 2018
1 Read

Urine proteomic profiling in patients with nephrolithiasis and cystinuria.

Int Urol Nephrol 2018 Dec 5. Epub 2018 Dec 5.

Nephrology Division, New York University Langone Medical Center, New York, NY, USA.

Purpose: The purpose of the study was to assess the differences in the concentration and function of urinary proteins between patients with cystine stones (CYS) and healthy controls (HC). We postulated that CYS and HC groups would demonstrate different proteomic profiles.

Methods: A pilot study was performed comparing urinary proteomes of 10 patients with CYS and 10 age- and gender-matched HC, using liquid chromatography-mass spectrometry. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s11255-018-2044-1
Publisher Site
http://dx.doi.org/10.1007/s11255-018-2044-1DOI Listing
December 2018
9 Reads

The effect of chronic kidney disease on lipid metabolism.

Int Urol Nephrol 2019 Feb 5;51(2):265-277. Epub 2018 Dec 5.

Division of Nephrology, Department of Medicine, Koc University School of Medicine, 34010, Istanbul, Turkey.

The major cause of death among chronic kidney disease patients is cardiovascular diseases. Cardiovascular and kidney disease are interrelated and increase the severity of each other. Dyslipidemia is one the major causes of cardiovascular disease among chronic kidney disease patients along with diabetes and hypertension. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11255-018-2047-yDOI Listing
February 2019
2 Reads

A modification with threading cannula needle-assisted 4-point suspension fixation for retroperitoneal laparoscopic pyeloplasty in children with ureteropelvic junction obstruction: a cohort study in single center.

Int Urol Nephrol 2019 Feb 5;51(2):193-199. Epub 2018 Dec 5.

Department of Urology, The Third Affiliated Hospital of Sun Yat-sen University, Tianhe Road 600, Guangzhou, 510630, Guangdong, China.

Purpose: To evaluate the effect and safety of modifying a threading cannula needle-assisted suspension fixation in retroperitoneal laparoscopic dismembered pyeloplasty (LDP) for children with congenital ureteropelvic junction obstruction (UPJO).

Methods: Between December 2012 and December 2017, 45 children (< 14 years of age) with congenital UPJO were divided into two groups. In Group A, children underwent conventional "no-suspension fixation" LDP; and in Group B, "4-point suspension fixation" LDP was performed to lower difficulties and shorten operative time. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11255-018-2048-xDOI Listing
February 2019
3 Reads

Foreskin reconstruction at the time of single-stage hypospadias repair: is it a safe procedure?

Int Urol Nephrol 2019 Feb 1;51(2):187-191. Epub 2018 Dec 1.

Paediatric Urology, Evelina London Children's Hospital, London, UK.

Introduction: Foreskin reconstruction (FR) is a recognised, yet debated, option for patients undergoing single-stage hypospadias repair (HR).

Methods: We evaluated the incidence of complications after single-stage HR in our institution. This is a retrospective review of all single-stage HR. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s11255-018-2043-2
Publisher Site
http://dx.doi.org/10.1007/s11255-018-2043-2DOI Listing
February 2019
15 Reads

Penile lymphedeme: a very rare complication due to bilateral subinguinal varicocelectomy.

Int Urol Nephrol 2019 Feb 1;51(2):261-262. Epub 2018 Dec 1.

Department of Urology, School of Medicine, Gazi University, Ankara, Turkey.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11255-018-2041-4DOI Listing
February 2019

The effects of oxytocin on penile tissues in experimental priapism model in rats.

Int Urol Nephrol 2019 Feb 4;51(2):231-238. Epub 2018 Dec 4.

Department of Urology, Faculty of Medicine, Gaziosmanpasa University, Tokat, Turkey.

Purpose: This study aimed to demonstrate the effects of oxytocin on penile tissues in ischemia-reperfusion injury developed after priapism.

Methods: Forty Wistar Albino strain male rats were divided into four groups. The control group (n = 10) was not intervened. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11255-018-2046-zDOI Listing
February 2019
4 Reads
1.293 Impact Factor