12,430 results match your criteria International journal of pharmaceutics[Journal]


Lipoic Acid-derived Cross-linked Liposomes for Reduction-responsive Delivery of Anticancer Drug.

Int J Pharm 2019 Feb 12. Epub 2019 Feb 12.

School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, PR China. Electronic address:

Liposomes have emerged as a fascinating nanocarriers for the delivery of cancer therapeutics. However, their efficacy for cancer therapy is reduced because of the serum-instability and incomplete drug release. In this study, a novel disulfide cross-linked liposomes (CLs) assembled from dimeric lipoic acid-derived glycerophosphorylcholine (di-LA-PC) conjugate was developed. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2019.02.007DOI Listing
February 2019

Correlating Multidimensional Short-Term Empirical Protein Properties to Long-Term Protein Physical Stability Data Via Empirical Phase Diagrams.

Int J Pharm 2019 Feb 12. Epub 2019 Feb 12.

Institute of Engineering in Life Sciences, Section IV: Biomolecular Separation Engineering, Karlsruhe Institute of Technology (KIT), Fritz-Haber-Weg 2, 76131 Karlsruhe, Germany. Electronic address:

Identification of long-term stable biopharmaceutical formulations is essential for biopharmaceutical product development. Reduction of the number of long-term storage experiments and a well-defined formulation search space requires knowledge-based formulation screenings and a detailed protein phase behavior understanding. To achieve this, short-term analytical techniques can serve as predictors for long-term protein phase behavior. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2019.02.006DOI Listing
February 2019

Ratiometric co-encapsulation and co-delivery of doxorubicin and paclitaxel by tumor-targeted lipodisks for combination therapy of breast cancer.

Int J Pharm 2019 Feb 12. Epub 2019 Feb 12.

Department of Pharmaceutics, School of Pharmacy, Jiangsu University, Zhenjiang 212013, PR China. Electronic address:

Combination therapy is a promising treatment for certain advanced drug-resistant cancers. Although effective inhibition of various tumor cells was reported in vitro, combination treatment requires improvement in vivo due to uncontrolled ratiometric delivery. In this study, a tumor-targeting lipodisk nanoparticle formulation was developed for ratiometric loading and the transportation of two hydrophobic model drugs, doxorubicin (DOX) and paclitaxel (PTX), in one single platform. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2019.02.009DOI Listing
February 2019

Mechanistic Study on Rapid Fabrication of Fibrous Films via Centrifugal Melt Spinning.

Int J Pharm 2019 Feb 12. Epub 2019 Feb 12.

College of Pharmacy, University of Rhode Island, Kingston, USA.

Fibrous films have attracted considerable attention in the field of drug delivery and wound dressings owing to their porous structure and highly aligned fiber orientation. However, current fabrication methods such as electrospinning have certain limitations, including high voltage requirement and conductivity dependency. This has greatly hindered the product development and applications of fibrous films. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2019.02.005DOI Listing
February 2019

Corrigendum to "Exosomes derived from TRAIL-engineered mesenchymal stem cells with effective anti-tumor activity in a mouse melanoma model" [International Journal of Pharmaceutics 549 (2018) 218-229].

Int J Pharm 2019 Mar;558:441

Pharmaceutical Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran; Department of Medicinal Chemistry, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:

Exosomes are biological nano-sized vesicles (~30-200 nm in diameter) that are produced by a wide range of cells and play several roles in cell-cell communications. These vesicles contain membrane and cytoplasmic components of producing cells. Mesenchymal stem cells (MSCs) are the ideal producer of exosomes. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2019.02.003DOI Listing

Non-aqueous formulations for ram and screen extrusion-spheronisation.

Int J Pharm 2019 Feb 11. Epub 2019 Feb 11.

Department of Chemical Engineering and Biotechnology, West Cambridge Site, Philippa Fawcett Drive, Cambridge, CB3 0AS, UK.

The use of non-aqueous cellulose-based formulations for extrusion-spheronisation (E-S) is investigated. A 10 wt% hydroxypropyl cellulose/isopropyl alcohol solution (HPC/IPA) was identified as a suitable sticky liquid binder for preparing non-aqueous pastes. Preliminary tests were performed on a series of pastes using a ram as well as a laboratory roller screen extruder, since the former is commonly used in batch testing and the latter replicates the shear range in a manufacturing screen extruder. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2019.01.075DOI Listing
February 2019

An overview on the mathematical modeling of hydrogels' behavior for drug delivery systems.

Authors:
Diego Caccavo

Int J Pharm 2019 Feb 11. Epub 2019 Feb 11.

Department of Industrial Engineering, University of Salerno, 84084 Fisciano, SA, Italy. Electronic address:

Hydrogels-based systems (HBSs) for drug delivery are nowadays extensively used and the interest in modeling their behavior is dramatically increasing. In this review a critical overview on the modeling approaches is given, quantitatively and qualitatively analyzing the publications on the subject, the trend of the publications per year and the type of modeling approaches. It was found that, despite the drug release fitting models (i. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2019.01.076DOI Listing
February 2019

Mucoadhesive olaminosomes: A novel prolonged release nanocarrier of agomelatine for the treatment of ocular hypertension.

Int J Pharm 2019 Feb 11. Epub 2019 Feb 11.

Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Cairo, Egypt. Electronic address:

Mucoadhesive olaminosomes are novel nanocarriers designed to control agomelatine release and enhance its bioavailability. Olaminosomes were prepared using oleic acid, oleylamine and sorbitan monooleate adopting thin film hydration technique. Chitosan HCl was added to impart the mucoadhesive properties to the olaminosomes. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2019.01.070DOI Listing
February 2019

Assessment of blend uniformity in a continuous tablet manufacturing process.

Int J Pharm 2019 Feb 11. Epub 2019 Feb 11.

Center for Structured Organic Particulate Systems (C-SOPS), Department of Chemical Engineering, University of Puerto Rico at Mayaguez, Puerto Rico, 00681, United States. Electronic address:

Blend uniformity was monitored throughout a continuous manufacturing (CM) process by near infrared (NIR) spectroscopic measurements of flowing blends and compared to the drug concentration in the tablets.The NIR spectra were obtained through the chute after the blender and within the feed frame, while transmission spectra were obtained for the tablets. The CM process was performed with semi-fine acetaminophen blends at 10. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2019.01.073DOI Listing
February 2019

Simvastatin-loaded solid lipid nanoparticles for enhanced anti-hyperlipidemic activity in hyperlipidemia animal model.

Int J Pharm 2019 Feb 9. Epub 2019 Feb 9.

Riphah Institute of Pharmaceutical Sciences, Riphah International University, Islamabad, Pakistan. Electronic address:

The objective of current study was to develop solid lipid nanoparticles-loaded with simvastatin (SIM-SLNs) and investigate their in vivo anti-hyperlipidemic activity in poloxamer-induced hyperlipidemia model. Nano-template engineering technique was used to prepare SIM-SLNs with palmityl alcohol as lipid core and a mixture of Tween 40/Span 40/Myrj 52 to stabilize the core. The prepared SIM-SLNs were evaluated for physicochemical parameters including particle diameter, surface charge, morphology, incorporation efficiency, thermal behaviour and crystallinity. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2019.02.002DOI Listing
February 2019

Tailoring Novel Soft Nano-vesicles 'Flexosomes' for Enhanced Transdermal Drug Delivery: Optimization, characterization and comprehensive ex vivo - in vivo evaluation.

Int J Pharm 2019 Feb 9. Epub 2019 Feb 9.

Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt; Pharmaceutical Technology Department, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo, Egypt.

The transdermal route is a convenient non-invasive way for drug delivery, however, the hydrophobic compact nature of stratum corneum (SC) forms an obstacle hindering the diffusion of drugs particularly hydrophilic ones. Hence, the purpose of this study was to develop novel soft nano-vesicles, entitled Flexosomes, amalgamating two penetration enhancers, ethanol and one edge activator (EA) from various types and different hydrophilic-lipophilic balances. The tailored vesicles were loaded with tropisetron hydrochloride (TRO), a potent highly-soluble anti-emetic, and compared with ethosomes. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2019.01.072DOI Listing
February 2019
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Sustained and controlled release of herbal medicines: The concept of synchronized release.

Int J Pharm 2019 Feb 9. Epub 2019 Feb 9.

Department of Pharmacy, Shanghai Dermatology Hospital, Shanghai 200443, China; Center for Medical Research and Innovation, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai, 201399, China; Key Laboratory of Smart Drug Delivery of MOE, School of Pharmacy, Fudan University, Shanghai 201203, China. Electronic address:

Synchronized release, defined as simultaneous release of multiple components while keeping the inter-component ratios steady, is crucial to the design and development of sustained- or controlled-release delivery systems of herbal medicines. A theory of infinite dose dividing is proposed to interpret the rationale behind synchronized release. The key point of the mechanisms is to curb diffusion so as to offset the release divergence caused by differences in physicochemical properties of multiple components. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2019.01.074DOI Listing
February 2019

Biomaterials for local drug delivery in central nervous system.

Int J Pharm 2019 Feb 8. Epub 2019 Feb 8.

Institute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China; Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cell and Regenerative Medicine, Zhejiang University, Hangzhou 310058, China. Electronic address:

The central nervous system (CNS) is a vital part of human body which coordinate the actions by transmitting signals. Because of the existence of the blood-brain barrier and the blood-spinal cord barrier, diseases in CNS can hardly be directly intervened by non-invasive methods. While systemic delivery usually requires extravagant drug dosage and leads into toxicity in unexpected tissues, local drug delivery in CNS tissues provides a solution for the problems of physiological barriers and systematic side effects. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2019.01.071DOI Listing
February 2019
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Fisetin loaded binary ethosomes for management of skin cancer by dermal application on UV exposed mice.

Int J Pharm 2019 Feb 8. Epub 2019 Feb 8.

Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard (Deemed University), M. B. Road New Delhi 110062, India.

Fisetin loaded binary ethosomes were prepared and optimized using Box-Behnken design for dermal application to alleviate skin cancer. The prepared formulations were evaluated for vesicle size, entrapment efficiency and flux of fisetin. Additionally, the optimized formulation was further evaluated by transmission electron microscopy, confocal laser microscopy, vesicles-skin interaction, dermatokinetic study and DPPH (2, 2-diphenyl-1-picryl-hydrazyl) assay. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2019.01.067DOI Listing
February 2019

A Study on the Applicability of Multiple Process Analysers in the Production of Coated Pellets.

Int J Pharm 2019 Feb 8. Epub 2019 Feb 8.

KRKA, d.d., Novo mesto, Šmarješka cesta 6, 8000 Novo mesto, Slovenia; University of Ljubljana, Faculty of Pharmacy, Aškerčeva 7, 1000 Ljubljana, Slovenia.

Process analytical technology (PAT) has become an important factor in design, analysis and control of complex technological processes. In the present study, pellet coating process was monitored using four different PAT approaches, i.e. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2019.01.069DOI Listing
February 2019

Novel bicephalous heterolipid based self-microemulsifying drug delivery system for solubility and bioavailability enhancement of efavirenz.

Int J Pharm 2019 Feb 8. Epub 2019 Feb 8.

Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Matunga (E), Mumbai 400019, India. Electronic address:

There is an increasing demand of new lipidic biocompatible and safe materials for self-microemulsifying drug delivery system (SMEDDS). The present work reports the synthesis, characterization, oral mucosal irritation study, and application of novel erucic acid ester of G-PETIM dendron based bicephalous heterolipid (BHL) as an oil phase in SMEDDS using Efavirenz (EFA), a BCS class II drug with poor water solubility and poor bioavailability. Studies were conducted to optimize EFA SMEDDS using different ratios of the BHL as oil phase and surfactant: co-surfactant weight ratios (Km). Read More

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http://dx.doi.org/10.1016/j.ijpharm.2019.01.065DOI Listing
February 2019
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Type 1 Diabetes Mellitus reversal via implantation of magnetically purified microencapsulated pseudoislets.

Authors:
A Espona-Noguera

Int J Pharm 2019 Feb 8. Epub 2019 Feb 8.

NanoBioCel Group, Laboratory of Pharmaceutics, School of Pharmacy, University of the Basque Country (UPV/EHU), Paseo de la Universidad 7, 01006, Vitoria-Gasteiz, Spain.

Microencapsulation of pancreatic islets for the treatment of Type I Diabetes Mellitus (T1DM) generates a high quantity of empty microcapsules, resulting in high therapeutic graft volumes that can enhance the host's immune response. We report a 3D printed microfluidic magnetic sorting device for microcapsules purification with the objective to reduce the number of empty microcapsules prior transplantation. In this study, INS1E pseudoislets were microencapsulated within alginate (A) and alginate-poly-L-lysine-alginate (APA) microcapsules and purified through the microfluidic device. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03785173193009
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http://dx.doi.org/10.1016/j.ijpharm.2019.01.058DOI Listing
February 2019
5 Reads

Powder die filling under gravity and suction fill mechanisms.

Int J Pharm 2019 Feb 8. Epub 2019 Feb 8.

Department of Engineering, University of Leicester, Leicester, LE1 7RH, United Kingdom.

In pharmaceutical tablet manufacturing, the powder formulation is filled into a die and compacted into a tablet using rigid punches. Die fill is important because it limits the productivity of tablet presses and determines key quality attributes of tablets including weight and content uniformity. Die fill occurs due to gravity and suction fill mechanisms. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2019.01.068DOI Listing
February 2019

Afatinib-loaded Immunoliposomes Functionalized with Cetuximab: a Novel Strategy Targeting the Epidermal Growth Factor Receptor for Treatment of Non-small-cell Lung Cancer.

Int J Pharm 2019 Feb 8. Epub 2019 Feb 8.

School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation, Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai, 264005, China.

Afatinib, a selective and irreversible inhibitor of tyrosine kinase, was approved for the treatment of advanced non-small-cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) overexpression in 2013. Cetuximab (CTX), an anti-EGFR monoclonal antibody, is co-administered with afatinib to improve efficacy. Unfortunately, dose-related adverse reactions caused by combination therapy have affected patient compliance, and have resulted in treatment discontinuation in severe cases. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2019.02.001DOI Listing
February 2019

Chitosan ascorbate hydrogel improves water uptake capacity and cell adhesion of electrospun poly(epsilon-caprolactone) membranes.

Int J Pharm 2019 Feb 6. Epub 2019 Feb 6.

Laboratory of Pharmaceutical Nanomaterials Science, Department of Materials Science and Engineering, Technion-Israel Institute of Technology, De-Jur Building, Technion City, 3200003, Haifa, Israel. Electronic address:

The most important prerequisites for wound coverage matrices are biocompatibility, adequate porosity, degradability and exudate uptake capacity. A moderate hydrophilicity and exudate uptake capacity can often favour cell adhesion and wound healing potential, however, most of the synthetic polymers like polycaprolactone (PCL) are hydrophobic. Hydrogels based on natural polymers can improve the hydrophilicity and exudate uptake capacity of synthetic dressings and improve healing. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2019.01.063DOI Listing
February 2019

A single-layer film coating for colon-targeted oral delivery.

Int J Pharm 2019 Feb 6. Epub 2019 Feb 6.

Department for Management of Science and Technology Development, Ton Duc Thang University, Ho Chi Minh City, Viet Nam; Faculty of Pharmacy, Ton Duc Thang University, Ho Chi Minh City, Viet Nam. Electronic address:

Most pH-sensitive polymer coating studies for potential colonic delivery systems apply multiple layers to protect the active agent from degradation and early release in the stomach and small intestine. This study designed a single-coat pH-sensitive layer for colon-specific delivery with a potential biopolymer, namely, zein. The tablets were coated with a pH-sensitive film combining zein and Kollicoat MAE 100P. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2019.01.066DOI Listing
February 2019

Optimization of preparation conditions for CTAB-modified Polygonatum sibiricum polysaccharide cubosomes using the response surface methodology and their effects on splenic lymphocytes.

Int J Pharm 2019 Feb 6. Epub 2019 Feb 6.

College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, PR China; Fujian Key Laboratory of Traditional Chinese Veterinary Medicine and Animal, Fujian Agriculture and Forestry University, Fuzhou 350002, PR China. Electronic address:

This study aimed to optimize the preparation conditions for cetyltrimethylammonium bromide-modified Polygonatum sibiricum polysaccharide cubosomes (CTAB-modified PSP-Cubs) by response surface methodology (RSM). Glyceryl-monooleate (GMO) was used as the lipid base for the cubosomes. The optimal preparation conditions of CTAB-modified PSP-Cubs were as follows: the mass percentage of PSP to GMO (X), Poloxamer 407 (F127) to GMO (X) and water to GMO (X) was 1. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2019.01.060DOI Listing
February 2019
1 Read
3.650 Impact Factor

Porous and highly dispersible voriconazole dry powders produced by spray freeze drying for pulmonary delivery with efficient lung deposition.

Int J Pharm 2019 Feb 4. Epub 2019 Feb 4.

Department of Pharmacology and Pharmacy, LKS Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong SAR, China. Electronic address:

Systemic administration of antifungal agents for the treatment of pulmonary aspergillosis is limited by the poor lung deposition and severe adverse effects. In contrast, pulmonary delivery allows a higher amount of drug to be delivered directly to the infection site and therefore a lower dose is required. This study aimed to develop porous and inhalable voriconazole dry powder with good lung deposition by spray freeze drying (SFD), using tert-butyl alcohol (TBA) as a co-solvent. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2019.01.057DOI Listing
February 2019
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Separation and identification of acylated leuprorelin inside PLGA microspheres.

Int J Pharm 2019 Feb 4. Epub 2019 Feb 4.

National Institutes for Food and Drug Control, No. 31, Huatuo Road, Daxing District, Beijing 102629, China. Electronic address:

Studies have shown that the N-terminus and lysine side residue of peptides are prone to acylation in poly(D,L-lactide-co-glycolide) (PLGA) microspheres. Peptides such as leuprorelin lack a free N-terminus or lysine and only contain serine, arginine, and tyrosine as nucleophilic residues. The purpose of this study was to detect potential acylation impurities and determine their corresponding acylation sites in commercial leuprorelin-loaded PLGA microspheres. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2019.01.061DOI Listing
February 2019
3.650 Impact Factor

Melatonin loaded with bacterial cellulose nanofiber by Pickering-emulsion solvent evaporation for enhanced dissolution and bioavailability.

Int J Pharm 2019 Feb 4;559:393-401. Epub 2019 Feb 4.

Key Laboratory of Forest Plant Ecology, Northeast Forestry University, Ministry of Education, Harbin 150040, Heilongjiang, China.

The objective of the present work aimed to explore the potential of bacterial cellulose (BC) for oral delivery of melatonin (MLT), a natural hormone that faces problems of low solubility and oral bioavailability. BC was hydrolyzed by sulfuric acid followed by the oxidation to prepare bacterial cellulose nanofiber suspension (BCNs). Melatonin-loaded bacterial cellulose nanofiber suspension (MLT-BCNs) was prepared by emulsion solvent evaporation method. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2019.01.059DOI Listing
February 2019

An evaluation of inhaled antibiotic liposome versus antibiotic nanoplex in controlling infection in bronchiectasis.

Int J Pharm 2019 Feb 4;559:382-392. Epub 2019 Feb 4.

School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore 637459, Singapore. Electronic address:

Inhaled antibiotic nanoparticles have emerged as an effective strategy to control infection in bronchiectasis lung owed to their mucus-penetrating ability. Using ciprofloxacin (CIP) as the model antibiotic, we evaluated dry powder inhaler (DPI) formulations of two classes of antibiotic nanoparticles (i.e. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2019.01.062DOI Listing
February 2019
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Advances in nanocarriers enabled brain targeted drug delivery across blood brain barrier.

Int J Pharm 2019 Feb 2;559:360-372. Epub 2019 Feb 2.

Institute for Skeletal Aging & Orthopedic Surgery, Hallym University-Chuncheon Sacred Heart Hospital, Chuncheon 200704, Republic of Korea; Department of Biotechnology, School of Life Science and Biotechnology, Adamas University, Barasat-Barrackpore Rd, Kolkata, West Bengal 700126, India. Electronic address:

The blood brain barrier (BBB) offers protection to the central nervous system (CNS) by maintaining homeostasis. Besides restricting the entry of harmful xenobiotics and endogenous molecules to CNS, BBB also limits the entry of therapeutic agents. Nanotechnology offers the possibility to deliver small molecules/drugs against CNS disorders across BBB. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03785173193009
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http://dx.doi.org/10.1016/j.ijpharm.2019.01.056DOI Listing
February 2019
7 Reads

Development of an amorphous nanosuspension by sonoprecipitation-formulation and process optimization using design of experiment methodology.

Int J Pharm 2019 Feb 2;559:348-359. Epub 2019 Feb 2.

Natoli Institute for Industrial Pharmacy Research and Development at Arnold and Marie Schwartz College of Pharmacy and Health Sciences, Long Island University, Brooklyn, NY, USA. Electronic address:

A Design of Experiment (DoE) methodology was adopted to investigate and optimize process parameters and formulations variables for preparing an amorphous clotrimazole (CLT) nanosuspension by sonoprecipitation technique. The amorphous nanosuspension can provide a synergistic effect of increase in dissolution velocity and kinetic solubility which can be advantageously used to improve bioavailability of low-solubility drugs. A Box-Behnken design was utilized to study the effect of formulation parameters (drug concentration, polymer concentration, and surfactant concentration) and process parameter (antisolvent: solvent ratio) on particle size, polydispersibility index (PDI), and zeta potential of amorphous CLT nanoparticles. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2019.01.054DOI Listing
February 2019

Antibacterial drug release from a biphasic gel system: Mathematical modelling.

Int J Pharm 2019 Feb 2;559:373-381. Epub 2019 Feb 2.

Department of Engineering and Architecture, Trieste University, via Valerio 6, I-34127 Trieste, Italy. Electronic address:

Bacterial infections represent an important drawback in the orthopaedic field, as they can develop either immediately after surgery procedures or after some years. Specifically, in case of implants, they are alleged to be troublesome as their elimination often compels a surgical removal of the infected implant. A possible solution strategy could involve a local coating of the implant by an antibacterial system, which requires to be easily applicable, biocompatible and able to provide the desired release kinetics for the selected antibacterial drug. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2019.01.055DOI Listing
February 2019

Handling forces for the use of different inhaler devices.

Int J Pharm 2019 Jan 31. Epub 2019 Jan 31.

Boehringer Ingelheim Pharma GmbH & Co. KG, Ingelheim, Germany. Electronic address:

Age and comorbidities can impact on the success of handling an inhaler. In this pilot study, we assessed finger strength in 62 participants (aged 5-17 years [n = 20], 18-65 years [n = 22] and > 65 years [n = 20]) by using different types of inhalers with integrated sensors (Respimat®, Breezhaler®, Aerolizer®, Genuair®, Diskus®, Ellipta®, HandiHaler®, Turbohaler® and a pressurized metered-dose inhaler [Atrovent®]). Parameters under investigation included the spontaneous and maximum achievable force and torque required to operate devices. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03785173193009
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http://dx.doi.org/10.1016/j.ijpharm.2019.01.053DOI Listing
January 2019
1 Read
3.650 Impact Factor

Spontaneously formed porous structure and M polarization effect of FeO nanoparticles for enhanced antitumor therapy.

Int J Pharm 2019 Jan 31;559:329-340. Epub 2019 Jan 31.

Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610064, PR China.

In this study, we developed a novel FeO nanoparticles-doxorubicin (DOX)-Hyaluronic acid (HA) nanoparticles on the basis of firstly discovered "formed porous structure" in spontaneously assembled FeO nanoparticles. The Mechanism of Action (MOA) behind this porous DOX-loading cargo was tested and confirmed. A multi-functional FeO-DOX+HA nanoparticle was further constructed by incorporating HA into our system. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2019.01.048DOI Listing
January 2019
1 Read

Entecavir-loaded poly (lactic-co-glycolic acid) microspheres for long-term therapy of chronic hepatitis-B: preparation and in vitro and in vivo evaluation.

Int J Pharm 2019 Jan 31. Epub 2019 Jan 31.

School of Pharmacy, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Yantai University, Yantai, Shandong Province, People's Republic of China. Electronic address:

To avoid severe exacerbations in the load of hepatitis B virus (HBV) as a consequence of discontinuous use of anti-HBV drugs, entecavir (ETV), the first-line anti-HBV drug, was primally formulated as extended-release poly (lactic-co-glycolic acid) microspheres in the present study. Because ETV is slightly soluble in water and in some other organic solvents used for microsphere preparation, methods for solid-microencapsulation were employed to fabricate the ETV microspheres. The optimized microspheres were evaluated for their morphology, particle size, drug loading, in vitro drug release, and in vivo pharmacokinetics in rats. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03785173193009
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http://dx.doi.org/10.1016/j.ijpharm.2019.01.052DOI Listing
January 2019
4 Reads

Storage stability of inhalable phage powders containing lactose at ambient conditions.

Int J Pharm 2019 Jan 30. Epub 2019 Jan 30.

Advanced Drug Delivery Group, School of Pharmacy, University of Sydney, Sydney, NSW, Australia. Electronic address:

The aim of this study was to evaluate the storage stability of inhalable phage powders containing lactose and leucine as excipient. As an FDA-approved excipient for inhalation, lactose is preferred over other sugars. PEV phages active against antibiotic-resistant Pseudomonas aeruginosa was spray dried with lactose (55-90%) and leucine (45-10%). Read More

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http://dx.doi.org/10.1016/j.ijpharm.2019.01.050DOI Listing
January 2019
1 Read

Enhancing analgesic and anti-inflammatory effects of capsaicin when loaded into olive oil nanoemulsion: An in vivo study.

Int J Pharm 2019 Jan 31;559:341-347. Epub 2019 Jan 31.

Natural Products and Medicinal Plants Research Center, North Khorasan University of Medical Sciences, Bojnurd, Iran; Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Topical preparations of capsaicin, the major pungent ingredient of hot pepper, are being used for management of pain and inflammatory disorders. Purpose of this study was to use nanoemulsion as an effective topical drug carrier for in vivo delivery of capsaicin. An oil-in-water nanoemulsion containing capsaicin was prepared by spontaneous emulsification method. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2019.01.043DOI Listing
January 2019
1 Read

Micelle-solubilized axitinib for ocular administration in anti-neovascularization.

Int J Pharm 2019 Jan 30. Epub 2019 Jan 30.

Institute of Biomedical Engineering, School of Ophthalmology & Optometry and Eye Hospital, Wenzhou Medical University, 270 Xueyuan Road, Wenzhou 325027, China. Electronic address:

The development of new blood vessels is directly related to the occurrence of eye diseases. Anti-angiogenic drugs can theoretically be extended to the treatment of ophthalmic diseases. In this study, axitinib, a class of tyrosine kinase inhibitors, was loaded via the amphiphilic copolymer MPEG-PCL, improving its dispersibility in water. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2019.01.051DOI Listing
January 2019

Retentive device for intravesical drug delivery based on water-induced shape memory response of poly(vinyl alcohol): design concept and 4D printing feasibility.

Int J Pharm 2019 Jan 30;559:299-311. Epub 2019 Jan 30.

Dipartimento di Scienze Farmaceutiche, Sezione di Tecnologia e Legislazione Farmaceutiche "Maria Edvige Sangalli", Università degli Studi di Milano, Milano, Italy.

The use of shape memory polymers exhibiting water-induced shape recovery at body temperature and water solubility was proposed for the development of indwelling devices for intravesical drug delivery. These could be administered via catheter in a suitable temporary shape, retained in the bladder for a programmed period of time by recovery of the original shape and eliminated with urine following dissolution/erosion. Hot melt extrusion and fused deposition modeling 3D printing were employed as the manufacturing techniques, the latter resulting in 4D printing because of the shape modifications undergone by the printed item over time. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2019.01.045DOI Listing
January 2019

Pluronic F127-based micelles for tumor-targeted bufalin delivery.

Int J Pharm 2019 Jan 30;559:289-298. Epub 2019 Jan 30.

College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, China. Electronic address:

In this study, we developed novel thermal and redox-responsive micelles based on the Pluronic F127 tri-block copolymer and employed these for redox-responsive intratumor release of bufalin, an anti-cancer drug. Pluronic F127 was first functionalized with carboxylate groups, and then assembled into micelles. The HOOC-F127-COOH micelles are 20 ± 4 nm in size at 37 °C, but expand to 281 ± 5 nm when cooled to 4 °C. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2019.01.049DOI Listing
January 2019

Peptide release from SEDDS containing hydrophobic ion pair therapeutic peptides measured by Taylor dispersion analysis.

Int J Pharm 2019 Jan 28;559:228-234. Epub 2019 Jan 28.

IBMM, University of Montpellier, CNRS, ENSCM, 34095 Montpellier, France. Electronic address:

Therapeutic peptides are facing an increasing interest as drugs for the treatment of many diseases. The challenge in the administration of such drugs, due to inherent properties of these peptides, is to make them bioavailable. Self-emulsifying drug delivery systems (SEDDS) are considered a suitable and promising strategy to deliver the peptides and increase their bioavailability. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2019.01.039DOI Listing
January 2019

Drug combination using an injectable nanomedicine hydrogel for glioblastoma treatment.

Int J Pharm 2019 Jan 28;559:220-227. Epub 2019 Jan 28.

Université catholique de Louvain, Louvain Drug Research Institute, Advanced Drug Delivery and Biomaterials, Brussels, Belgium. Electronic address:

Lauroyl-gemcitabine lipid nanocapsules (GemC-LNC) hydrogel, administered intratumorally or perisurgically in the tumor resection cavity, increases animal survival in several orthotopic GBM models. We hypothesized that GemC-LNC can be used as nanodelivery platform for other drugs, to obtain a combined local therapeutic approach for GBM. Paclitaxel (PTX) was selected as a model molecule and PTX-GemC-LNC formulation was evaluated in terms of physicochemical and mechanical properties. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2019.01.042DOI Listing
January 2019

Advances of nanosystems containing cyclodextrins and their applications in pharmaceuticals.

Int J Pharm 2019 Jan 29;559:312-328. Epub 2019 Jan 29.

Department of Pharmacy, Federal University of Sergipe, São Cristóvão, Brazil. Electronic address:

For many years, researchers have worked with supramolecular structures involving inclusion complexes with cyclodextrins. These studies have resulted in new commercially available drugs which have been of great benefit. More recently, studies using nanoparticles, including nanosystems containing cyclodextrins, have become a focus of academic research due to the versatility of the systems and their remarkable therapeutic potential. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2019.01.041DOI Listing
January 2019

Hot-melt extrusion process impact on polymer choice of glyburide solid dispersions: The effect of wettability and dissolution.

Int J Pharm 2019 Jan 27;559:245-254. Epub 2019 Jan 27.

Department of Pharmacy, University of Huddersfield, Huddersfield HD1 3DH, UK. Electronic address:

The aim of this study was to evaluate the choice of polymer and polymer level on the performance of the microstructure and wettability of hot-melt extruded solid dispersion of Glyburide (Gly) as a model drug. The produced solid dispersion were characterised using scanning electron microscopy (SEM), image analysis using a focus variation instrument (FVI), differential scanning calorimetry (DSC), X-ray powder diffraction (XRPD), X-ray microtomography (XµT), dynamic contact angle measurement and dissolution analysis using biorelevant dissolution media (FASSIF). SEM and focus variation analysis showed that the microstructure and surface morphology was significantly different between samples produced. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03785173193007
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http://dx.doi.org/10.1016/j.ijpharm.2019.01.038DOI Listing
January 2019
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Saporin-loaded CD44 and EGFR dual-targeted nanogels for potent inhibition of metastatic breast cancer in vivo.

Int J Pharm 2019 Jan 27. Epub 2019 Jan 27.

Biomedical Polymers Laboratory, and Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, 215123, People's Republic of China. Electronic address:

Metastasis poses a long-standing treatment challenge for many cancers including breast cancer. Once spreading out, cell-selective delivery of drug appears especially critical. Here, we report on epidermal growth factor receptor and CD44 dual-targeted hyaluronic acid nanogels (EGFR/CD44-NGs) that afford enhanced targetability and protein therapy for metastatic 4T1 breast cancer in vivo. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03785173193007
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http://dx.doi.org/10.1016/j.ijpharm.2019.01.040DOI Listing
January 2019
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A new melatonin oral delivery platform based on orodispersible films containing solid lipid microparticles.

Int J Pharm 2019 Jan 25;559:280-288. Epub 2019 Jan 25.

Department of Pharmaceutical Sciences, Università degli Studi di Milano, Via G. Colombo 71, 20133 Milano, Italy.

An innovative delivery system for melatonin, based on the incorporation of solid lipid microparticles in orodispersible films (ODFs) made of maltodextrin, was designed and developed. Lipid microparticles at two different melatonin concentrations (10 and 20% w/w) were produced by the spray congealing technology using two different lipid carrier (tristearin and hydrogenated castor oil) and characterized in terms of size, solid state, drug loading and drug release pattern. Tristearin microparticles were discarded due to a polymorphic modification of the carrier. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2019.01.046DOI Listing
January 2019

In situ thermo-co-electroresponsive mucogel for controlled release of bioactive agent.

Int J Pharm 2019 Jan 26;559:255-270. Epub 2019 Jan 26.

Wits Advanced Drug Delivery Platform Research Unit, Department of Pharmacy and Pharmacology, School of Therapeutic Sciences, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, 7 York Road, Parktown, 2193, South Africa. Electronic address:

The purpose of this work was to develop an in situ thermosensitive electro-responsive mucoadhesive gel loaded with bioactive agent (nanocomposite) meant for nose to brain delivery in a controllable manner when electric stimulation is applied. Nanocomposite was developed using a combinatorial blending of chitosan, hydroxypropylmethylcellulose, pluronic F127 and polyaniline which was then loaded with BCNU-Nano-co-Plex (the bioactive agent). The nanocomposite was a liquid at room temperature but formed an in situ mucogel at a temperature of 27. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2019.01.044DOI Listing
January 2019

Glycyrrhizic acid as a multifunctional drug carrier - From physicochemical properties to biomedical applications: A modern insight on the ancient drug.

Int J Pharm 2019 Jan 25;559:271-279. Epub 2019 Jan 25.

Voevodsky Institute of Chemical Kinetics and Combustion of Siberian Branch of the Russian Academy of Sciences, Institutskaya St., 3, 630090 Novosibirsk, Russia.

Glycyrrhizic acid is the main active component of Licorice root which has been known in traditional Chinese and Japanese medicine since ancient times. In these cultures glycyrrhizic acid (GA) is one of the most frequently used drugs. However, only in 21-st century a novel unusual property of the GA to enhance the activity of other drugs has been discovered. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2019.01.047DOI Listing
January 2019
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In vitro dissolution testing of respirable size anti-tubercular drug particles using a small volume dissolution apparatus.

Int J Pharm 2019 Jan 23;559:235-244. Epub 2019 Jan 23.

School of Pharmacy, University of Otago, 18 Frederick St, Dunedin 9054, New Zealand. Electronic address:

A dissolution apparatus that uses a small volume of stationary medium (25 μL) has been developed for in vitro dissolution testing of respirable drug particles and used to evaluate the dissolution of two anti-tubercular drugs, moxifloxacin and ethionamide. Solubilities of moxifloxacin and ethionamide in phosphate buffered saline (PBS, pH 7.4) were 17. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2019.01.035DOI Listing
January 2019
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Fabrication of levofloxacin polyethylene glycol decorated nanoliposomes for enhanced management of acute otitis media: Statistical optimization, trans-tympanic permeation and in vivo evaluation.

Int J Pharm 2019 Jan 23;559:201-209. Epub 2019 Jan 23.

Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Cairo, Egypt. Electronic address:

Acute otitis media (AOM), an infection in the middle ear, is usually treated through systemic administration of antibiotics because the stratum corneum of the intact tympanic-membrane (TM) possesses low permeability that holds against the ototopical antibiotics use. Therefore, the objective of this work was to encapsulate levofloxacin (LFX) into polyethylene glycol 400 (PEG 400) decorated nanoliposomes (PNLs) as an approach for drug delivery through the intact tympanic-membrane. LFX loaded-PNLs were primed by ethanol injection technique. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03785173193007
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http://dx.doi.org/10.1016/j.ijpharm.2019.01.037DOI Listing
January 2019
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Vesicle-like structure of lipid-based nanoparticles as drug delivery system revealed by molecular dynamics simulations.

Int J Pharm 2019 Jan 23;559:173-181. Epub 2019 Jan 23.

Zanjan Pharmaceutical Nanotechnology Research Center, Zanjan University of Medical Sciences, 45139-56184 Zanjan, Iran.

Lipid-based drug delivery systems are considered as promising vehicles for hydrophobic drug compounds. Lipid distribution within the droplet can affect drug loading capacity in these carriers. However, it is extremely challenging to determine the nanostructure within these carriers through the implementation of the direct experimental methods due to the ultrafine size. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2019.01.036DOI Listing
January 2019

Localized drug delivery with mono and bilayered mucoadhesive films and wafers for oral mucosal infections.

Int J Pharm 2019 Jan 22;559:102-112. Epub 2019 Jan 22.

Hacettepe University, Faculty of Pharmacy, Department of Pharmaceutical Technology, 06100 Ankara, Turkey. Electronic address:

Local drug delivery into oral cavity offers many advantages over systemic administration in treatment of the oral infections. In this study, monolayer and bilayered mucoadhesive film and wafer formulations were developed as local drug delivery platforms using chitosan and hydroxypropyl methylcellulose (HPMC). Cefuroxime axetil (CA) was used as the model drug. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2019.01.029DOI Listing
January 2019

Roller compaction: Ribbon splitting and sticking.

Int J Pharm 2019 Jan 22;559:156-172. Epub 2019 Jan 22.

Department of Chemical and Biological Engineering, University of Sheffield, Sheffield S1 3JD, UK.

Roller compaction is the main technique employed in dry granulation. Ribbon sticking and splitting are among the major factors that can hinder the use of this process for some formulations. Ribbon splitting can occur either transversally (through the ribbon thickness) or longitudinally (through the ribbon width). Read More

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http://dx.doi.org/10.1016/j.ijpharm.2019.01.031DOI Listing
January 2019
1 Read