508,032 results match your criteria International journal of pediatric obesity : IJPO : an official journal of the International Association for the Study of Obesity[Journal]


Aqueous shunts with mitomycin C versus aqueous shunts alone for glaucoma.

Cochrane Database Syst Rev 2019 Apr 19;4:CD011875. Epub 2019 Apr 19.

Ophthalmology, Singapore National Eye Centre, Singapore, Singapore.

Background: Glaucoma affects more than 70 million people worldwide, with about 10% being bilaterally blind, making it the leading cause of irreversible blindness globally. In patients with advanced glaucoma or those who have failed medical treatment without achieving adequate intraocular pressure (IOP) control, trabeculectomy (glaucoma filtration surgery where an ostium is created into the anterior chamber from underneath a partial thickness scleral flap to allow for aqueous flow out of the anterior chamber intointo the subconjunctival space forming a filtering bleb) and aqueous shunt surgery for more complex and refractory cases remain the mainstay therapies. Proliferation of fibrous tissue around an implanted aqueous shunt may block the diffusion of aqueous humour. Read More

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http://doi.wiley.com/10.1002/14651858.CD011875.pub2
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http://dx.doi.org/10.1002/14651858.CD011875.pub2DOI Listing
April 2019
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Highlights from RöKo International.

Authors:

Rofo 2019 May 18;191(5):457. Epub 2019 Apr 18.

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http://dx.doi.org/10.1055/a-0864-8263DOI Listing

The Mealtime Assessment Scale (MAS): Part 1 - Development of a Scale for Meal Assessment.

Folia Phoniatr Logop 2019 Apr 18:1-13. Epub 2019 Apr 18.

Department of Biomedical and Clinical Sciences "L. Sacco," Università degli Studi di Milano, Milan, Italy.

Aims: Safety and efficacy of swallowing in instrumental assessment may not overlap safety and efficacy of swallowing during meal, as personal and environmental factors can influence the performance. This study aims to develop a scale to assess the safety and efficacy of swallowing during meal.

Methods: A working group discussed the latent construct, target population, and purposes of the scale. Read More

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http://dx.doi.org/10.1159/000494135DOI Listing

Overview of bioremediation with technology assessment and emphasis on fungal bioremediation of oil contaminated soils.

J Environ Manage 2019 Apr 15;241:156-166. Epub 2019 Apr 15.

PROFNIT - Professional Post-Graduate Program in Intellectual Property and Technology Transfer for Innovation, Federal University of Bahia, Campus de Ondina, R. Barão de Jeremoabo, 147, Ondina, Salvador, BA, 40170-115, Brazil; José de Anchieta College, Av. João Durval Carneiro, n. 3039, São João, Feira de Santana, BA, 44051-605, Brazil. Electronic address:

Environmental contamination is a problem that requires sustainable solutions. Bioremediation technologies have been developed in the last decades and are increasingly used to mitigate environmental accidents and systematic contaminations. A review of bioremediation technologies, based on published article and patent documents, is presented for different types of contaminated matrices, bioremediation agents and contaminants. Read More

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http://dx.doi.org/10.1016/j.jenvman.2019.04.019DOI Listing

Exposure effects of endotoxin-free titanium-based wear particles to human osteoblasts.

J Mech Behav Biomed Mater 2019 Apr 10;95:143-152. Epub 2019 Apr 10.

Department of Physics, UNESP, São Paulo State University, 17033-360, Bauru, SP, Brazil.

Titanium-based materials are widely employed by the biomedical industry in orthopedic and dental implants. However, when placed into the human body, these materials are highly susceptible to degradation processes, such as corrosion, wear, and tribocorrosion. As a consequence, metallic ions or particles (debris) may be released, and although several studies have been conducted in recent years to better understand the effects of their exposure to living cells, a consensual opinion has not yet been obtained. Read More

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http://dx.doi.org/10.1016/j.jmbbm.2019.04.003DOI Listing

Increasing DNA content for cost-effective oil production in Parachlorella kessleri.

Bioresour Technol 2019 Apr 11;285:121332. Epub 2019 Apr 11.

State Key Laboratory of Microbial Metabolism and School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China; Joint International Research Laboratory of Metabolic & Developmental Sciences, Shanghai Jiao Tong University, Shanghai 200240, China; Biomass Energy Research Center, Shanghai Jiao Tong University, Shanghai 200240, China. Electronic address:

The aim of this work was to study salt stress effects on DNA content and oil production processes integrating harvesting, lipid accumulation and oil extraction. Salt-induced enlargement of Parachlorella kessleri cells, with increasing content of DNA and neutral lipid were found. The 34. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09608524193055
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http://dx.doi.org/10.1016/j.biortech.2019.121332DOI Listing
April 2019
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Trophic transfer of cyclic methyl siloxanes in the marine food web in the Bohai Sea, China.

Ecotoxicol Environ Saf 2019 Apr 15;178:86-93. Epub 2019 Apr 15.

International Joint Research Centre for Persistent Toxic Substances (IJRC-PTS), College of Environmental Science and Engineering, Dalian Maritime University, Dalian, 116026, China. Electronic address:

Trophic transfer of cyclic methyl siloxanes (CMS) in aquatic ecosystems is an important criterion for assessing its environmental risks. This study researched the trophic transfer of four CMS (octamethylcyclotetrasiloxane (D), decamethylcyclopentasiloxane (D), dodecamethylcyclohexasiloxane (D), and tetradecamethylcycloheptasiloxane (D)) in marine food web from zooplankton up to seabirds in the Chinese Bohai Sea. In the zooplankton-invertebrate-fish-seabird based food web, the significant trophic magnifications were found for D to D (D: R = 0. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2019.04.034DOI Listing

Successful outcome after Pancreaticodoudenectomy in an elderly cirrhotic patient: A case report.

Int J Surg Case Rep 2019 Apr 10;58:18-20. Epub 2019 Apr 10.

Department of HPB Surgery and Liver Transplantation, Shifa International Hospital, Islamabad, Pakistan; Department of Surgery, Shifa Tameer-e-Millat University, Islamabad, Pakistan. Electronic address:

Introduction: Cirrhosis is a risk factor for poor outcomes in non-hepatic oncological resections. There are only a handful of cases demonstrating outcomes of pancreaticoduodenectomy (PD) in patients with pancreatic cancer and underlying cirrhosis. Moreover, pushing the limits of PD to elderly cirrhotic patients and demonstrating its safety remains under reported. Read More

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http://dx.doi.org/10.1016/j.ijscr.2019.03.034DOI Listing

Environmental impacts of dietary quality improvement in China.

J Environ Manage 2019 Apr 15;240:518-526. Epub 2019 Apr 15.

Institute for Interdisciplinary Information Sciences, Tsinghua University, Beijing, 100084, China.

Dietary-related risks rank top among all the health risks in many countries. The 2nd United Nations Sustainable Development Goal aims to end hunger, achieve food security and improved nutrition and promote sustainable agriculture. Yet whether improving nutritional quality also benefits the environment is still under-explored, particularly for developing countries. Read More

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http://dx.doi.org/10.1016/j.jenvman.2019.03.106DOI Listing

The use of Episcissors-60 to reduce the rate of Obstetric Anal Sphincter Injuries: A systematic review.

Eur J Obstet Gynecol Reprod Biol 2019 Apr 6;237:23-27. Epub 2019 Apr 6.

University Hospital Coventry, Clifford Bridge Road, Coventry, UK.

Objectives: The aim of this systematic review is to evaluate the effect of Episcissors-60, which were designed to improve the accuracy of episiotomies, on the rate of Obstetric Anal Sphincter Injuries.

Study Design: This review is registered with the International Prospective Register of Systematic Reviews (PROSPERO) database (CRD42018094935). A literature search of the PubMed, Embase and Cochrane databases was performed from inception to May 2018. Read More

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http://dx.doi.org/10.1016/j.ejogrb.2019.04.004DOI Listing

De-escalation of complexity in oncoplastic breast surgery: Case series from a specialized breast center.

Breast 2019 Apr 9;46:12-18. Epub 2019 Apr 9.

Multidisciplinary Breast Unit, Azienda Ospedaliera Cannizzaro, Catania, Italy.

Introduction: Oncoplastic breast surgery has evolved the surgical treatment of breast cancer over the past two decades. This practice still lacks validation and poses several dilemmas in terms of safety, local and systemic control, timing of adjuvant treatments and cost-effectiveness. Our case series investigates the effects of a reduced surgical complexity on cosmetic results and quality of life. Read More

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http://dx.doi.org/10.1016/j.breast.2019.04.002DOI Listing

Preloss Psychosocial Resources Predict Depressive-Symptom Trajectories among Terminally Ill Cancer Patients' Caregivers in their First Two Years of Bereavement.

J Pain Symptom Manage 2019 Apr 15. Epub 2019 Apr 15.

Division of Hematology-Oncology, Chang Gung Memorial Hospital at Linkou, Tao-Yuan, Taiwan; Department of Nursing, Chang Gung Memorial Hospital at Kaohsiung; School of Nursing, Chang Gung University, Tao-Yuan, Taiwan. Electronic address:

Context: Postloss depressive-symptom trajectories are heterogeneous and predicted by preloss psychosocial resources, but this evidence was from one old study on terminal cancer patients' caregivers for whom these issues are highly relevant.

Objectives: To identify depressive-symptom trajectories among cancer patients' bereaved caregivers and examine if they are predicted by preloss psychosocial resources while considering caregiving burden.

Methods: Preloss psychosocial resources (sense of coherence [SOC] and social support) were measured among 282 caregivers. Read More

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http://dx.doi.org/10.1016/j.jpainsymman.2019.04.003DOI Listing

Development and pharmacokinetics of a combination vaginal ring for sustained release of dapivirine and the protein microbicide 5P12-RANTES.

Int J Pharm 2019 Apr 15. Epub 2019 Apr 15.

School of Pharmacy, Queen's University Belfast, Belfast BT9 7BL, UK. Electronic address:

The past fifteen years have witnessed a resurgence of interest in vaginal ring technologies for drug delivery applications, mostly driven by the impetus for development of vaginally-administered antiretroviral microbicides to help reduce the high acquisition rates for human immunodeficiency virus (HIV) among Sub-Saharan African women. Currently, the lead candidate microbicide is a 28-day silicone elastomer vaginal ring releasing dapivirine (Ring-004), an experimental non-nucleoside reverse transcriptase inhibitor. The ring was tested in two pivotal Phase III clinical studies in 2016 and is currently undergoing review by the European Medicines Agency. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2019.04.040DOI Listing

A prospective evaluation of the 'C.O.A.C.H.E.D.' cognitive aid for emergency defibrillation.

Australas Emerg Care 2018 Aug 10;21(3):81-86. Epub 2018 Sep 10.

Sydney Medical School, University of Sydney, Sydney, Australia; Simulated Learning Environment for Clinical Training (SiLECT), Sydney, Australia.

Introduction: International guidelines recommend that interruptions to chest compressions are minimised during defibrillation. As a result, some resuscitation educators have adopted a more structured approach to defibrillation. One such approach is the 'C. Read More

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http://dx.doi.org/10.1016/j.auec.2018.08.002DOI Listing

Knowledge and attitude towards identification of systemic inflammatory response syndrome (SIRS) and sepsis among emergency personnel in tertiary teaching hospital.

Australas Emerg Care 2019 Mar 15;22(1):13-21. Epub 2018 Dec 15.

Department of Emergency Medicine, University of Kebangsaan Malaysia, Kuala Lumpur, Malaysia.

Introduction: An emergency department (ED) is often the first point of medical contact for sepsis patient, which plays an important role in early identification and management of high-risk septic patients. The present study was aim to evaluate emergency personnel's knowledge and attitude toward identification and management of systemic inflammatory response syndrome (SIRS) and sepsis.

Methods: This cross-sectional study was conducted in a tertiary teaching hospital and recruited all emergency personnel. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S2588994X183005
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http://dx.doi.org/10.1016/j.auec.2018.11.002DOI Listing
March 2019
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Functional characterization of CEP250 variant identified in nonsyndromic retinitis pigmentosa.

Hum Mutat 2019 Apr 18. Epub 2019 Apr 18.

Division of Ophthalmic Genetics, The Eye Hospital, Wenzhou Medical University, Wenzhou, China.

Retinitis pigmentosa (RP) is the most common manifestation of inherited retinal diseases with high degree of genetic, allelic, and phenotypic heterogeneity. CEP250 encodes the C-Nap1 protein and has been associated with various retinal phenotypes. Here, we report the identification of a mutation (c. Read More

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http://dx.doi.org/10.1002/humu.23759DOI Listing

Novel CaCoxZr1-xO3-δ perovskites as oxygen-selective sorbents for air separation.

ChemSusChem 2019 Apr 18. Epub 2019 Apr 18.

North Carolina State University, UNITED STATES.

ABO3-δ perovskites are ideal for high temperature thermochemical air separation for oxygen production, due to the fact that their oxygen nonstoichiometry δ can be varied in response to changes in temperature and oxygen partial pressure. We are reporting outstanding oxygen sorption performance of CaCoxZr1-xO3-δ perovskites and their potential application as oxygen-selective sorbents for air separation. In situ thermal XRD was used to study the material structural changes in response to temperature variations in air or inert atmosphere. Read More

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http://dx.doi.org/10.1002/cssc.201900644DOI Listing

Subcutaneous vs Intravenous Trastuzumab for Patients With ERBB2-Positive Early Breast Cancer: Final Analysis of the HannaH Phase 3 Randomized Clinical Trial.

JAMA Oncol 2019 Apr 18:e190339. Epub 2019 Apr 18.

Department of Gynecology and Obstetrics, Hospital Pérola Byington, São Paulo, Brazil.

Importance: Confirmation of long-term comparability between subcutaneous and intravenous trastuzumab is essential.

Objective: To evaluate efficacy and safety of subcutaneous trastuzumab compared with that of intravenous trastuzumab for patients with ERBB2 (HER2)-positive early breast cancer after 6 years' follow-up in the HannaH (Enhanced Treatment With Neoadjuvant Herceptin) trial.

Design, Setting, And Participants: Open-label, prospective, multicenter, international, neoadjuvant-adjuvant, randomized, phase 3 noninferiority clinical trial (primary end points: pathologic complete response and serum trough concentration predose cycle 8) conducted for 596 patients with ERBB2-positive early breast cancer enrolled from October 19, 2009, to December 1, 2010. Read More

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http://oncology.jamanetwork.com/article.aspx?doi=10.1001/jam
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http://dx.doi.org/10.1001/jamaoncol.2019.0339DOI Listing
April 2019
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Association of Exercise and Swimming Goggles With Modulation of Cerebro-ocular Hemodynamics and Pressures in a Model of Spaceflight-Associated Neuro-ocular Syndrome.

JAMA Ophthalmol 2019 Apr 18. Epub 2019 Apr 18.

Integrated Cardiovascular Exercise Physiology and Rehabilitation Laboratory, College of Nursing and Health Innovation, University of Texas at Arlington, Arlington.

Importance: Astronauts on International Space Station missions demonstrate adverse neuro-ocular changes. Reversing a negative translaminar pressure gradient (TLPG) by modulating cerebral blood flow, decreasing intracranial pressure, or increasing intraocular pressure (IOP) has been proposed as potential intervention for spaceflight-associated neuro-ocular syndrome (SANS).

Objective: To examine whether exercise (resistance, moderate-intensity aerobic, and high-intensity aerobic) or artificially increasing IOP is associated with modulated cerebro-ocular hemodynamic and pressure changes during head-down tilt (HDT), an analogue of spaceflight, in healthy adults. Read More

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http://dx.doi.org/10.1001/jamaophthalmol.2019.0459DOI Listing

What is the effect of a Mediterranean compared with a Fast Food meal on the exercise induced adipokine changes? A randomized cross-over clinical trial.

PLoS One 2019 18;14(4):e0215475. Epub 2019 Apr 18.

Basic and Clinical Immunology, Department of Pathology, Faculty of Medicine, University of Porto, Porto, Portugal.

Background: Adipose tissue-derived adipokines are pro-inflammatory cytokines involved in metabolic-related diseases and can be influenced by diet and exercise. We aimed to compare the effect of a Mediterranean (MdM) compared with Fast Food (FFM) meal on the exercise induced adipokines changes.

Methods: In a double blinded cross over trial, 46 participants were randomly assigned to one of two standardized iso-energy pre-exercise meals: FFM or MdM-type. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215475PLOS

Population prevalence of myopia, glasses wear and free glasses acceptance among minority versus Han schoolchildren in China.

PLoS One 2019 18;14(4):e0215660. Epub 2019 Apr 18.

Lancang County First People's Hospital, Lancang, Yunnan, China.

Aim: To measure myopia, glasses wear and free glasses acceptance among minority and Han children in China.

Methods: Visual acuity testing and questionnaires assessing ethnicity, study time, and parental and teacher factors were administered to a population-based sample of 9-12 year old minority and Han children in Yunnan and Guangdong, and their teachers and parents. Refraction was performed on children with uncorrected visual acuity (VA) < = 6/12 in either eye, and acceptance of free glasses assessed. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215660PLOS

Farmers' perceptions on the causes of cassava root bitterness: A case of konzo-affected Mtwara region, Tanzania.

PLoS One 2019 18;14(4):e0215527. Epub 2019 Apr 18.

Roots and Tubers Department, Naliendele Agricultural Research Institute, Mtwara, Tanzania.

In areas where konzo (a cassava cyanide related paralytic disorder) persists, the agronomic factors causing increased cyanogenic glucoside levels in cassava, during periods without water stress, are hardly known. However, through their assessment of cassava root toxicity, using its bitter taste, farmers may have noticed factors unrelated to water stress that additionally influence the cyanogenic glucoside content of cassava cultivated in these areas. Increased cassava root bitterness is often associated with an increase in cyanogenic glucoside levels, making it a good indicator of changes in root cyanogenic glucoside content. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215527PLOS

Wide sensory filters underlie performance in memory-based discrimination and generalization.

PLoS One 2019 18;14(4):e0214817. Epub 2019 Apr 18.

Department of Neurogenetics, Max Planck Institute of Experimental Medicine, Göttingen, Germany.

The way animals respond to a stimulus depends largely on an internal comparison between the current sensation and the memory of previous stimuli and outcomes. We know little about the accuracy with which the physical properties of the stimuli influence this type of memory-based discriminative decisions. Research has focused largely on discriminations between stimuli presented in quick succession, where animals can make relative inferences (same or different; higher or lower) from trial to trial. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214817PLOS
April 2019
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Barriers and facilitators of communication about off periods in Parkinson's disease: Qualitative analysis of patient, carepartner, and physician Interviews.

PLoS One 2019 18;14(4):e0215384. Epub 2019 Apr 18.

Morton and Gloria Shulman Movement Disorders Centre and the Edmond J Safra Program in Parkinson's Research, Toronto Western Hospital, Toronto, Ontario, Canada.

Background: Successful patient-physician communication is critical for improving health outcomes, but research regarding optimal communication practices in Parkinson's disease is limited. The objective of the current study was to investigate barriers and facilitators of communication between persons with Parkinson's disease, carepartners, and physicians, specifically in the setting of off periods, with the goal of identifying ways to improve patient-carepartner-physician communication.

Method: We interviewed persons with Parkinson's, carepartners, and physicians (specialists and non-specialists) using a semi-structured questionnaire to identify and describe experiences, barriers, and facilitators relating to communication about off periods in Parkinson's disease. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215384PLOS

Combating infectious disease epidemics through China's Belt and Road Initiative.

PLoS Negl Trop Dis 2019 Apr 18;13(4):e0007107. Epub 2019 Apr 18.

National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, Shanghai, China.

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http://dx.doi.org/10.1371/journal.pntd.0007107DOI Listing
April 2019
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Harmonization of resting-state functional MRI data across multiple imaging sites via the separation of site differences into sampling bias and measurement bias.

PLoS Biol 2019 Apr 18;17(4):e3000042. Epub 2019 Apr 18.

Brain Information Communication Research Laboratory Group, Advanced Telecommunications Research Institutes International, Kyoto, Japan.

When collecting large amounts of neuroimaging data associated with psychiatric disorders, images must be acquired from multiple sites because of the limited capacity of a single site. However, site differences represent a barrier when acquiring multisite neuroimaging data. We utilized a traveling-subject dataset in conjunction with a multisite, multidisorder dataset to demonstrate that site differences are composed of biological sampling bias and engineering measurement bias. Read More

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http://dx.doi.org/10.1371/journal.pbio.3000042DOI Listing

Combining Spinal-Epidural Anesthesia versus Single-Shot Spinal Anesthesia for Cesarean Delivery: A Meta-Analysis of 5 Randomized Controlled Trials.

Med Sci Monit 2019 Apr 18;25:2859-2867. Epub 2019 Apr 18.

Department of International Medical, China-Japan Friendship Hospital, Beijing, China (mainland).

BACKGROUND This study compared combined spinal-epidural anesthesia (CSEA) and single-shot spinal anesthesia (SSSA) by performing a meta-analysis. MATERIAL AND METHODS An electronic search of relevant studies was done through 2017. Primary endpoints included duration of surgery, and time for (1) sensory recovery to thoracic vertebra (T10), (2) maximal sensory, (3) motor blockade, and (4) motor recovery. Read More

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http://dx.doi.org/10.12659/MSM.913744DOI Listing

Pathways to Independent Primary Care Clinical Practice: How Tall Is the Shortest Giant?

Acad Med 2019 Apr 16. Epub 2019 Apr 16.

M.J. Dewan is interim president and SUNY Distinguished Service Professor, Upstate Medical University, Syracuse, New York. J.J. Norcini is president and CEO, Foundation for the Advancement of International Medical Education and Research, Philadelphia, Pennsylvania.

Patients can be treated by a physician, a nurse practitioner (NP), or a physician assistant (PA) despite marked differences in the education and training for these three professions. This natural experiment allows examination of a critical question: what is the minimum education and training required to practice primary care? In other words, how tall is the shortest giant? State licensing requirements, not educational bodies, legislate minimum training. The current minimum is 6 years, which includes 27. Read More

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http://dx.doi.org/10.1097/ACM.0000000000002764DOI Listing

SQUIRE-EDU (Standards for QUality Improvement Reporting Excellence in Education): Publication Guidelines for Educational Improvement.

Acad Med 2019 Apr 16. Epub 2019 Apr 16.

G. Ogrinc is senior associate dean for medical education, and professor of medicine, the Dartmouth Institute, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire. G.E. Armstrong is associate professor, University of Colorado College of Nursing, Aurora, Colorado. M.A. Dolansky is associate professor, Case Western Reserve University, Frances Payne Bolton School of Nursing, and Department of Veterans Affairs Louis Stokes Medical Center, Cleveland, Ohio. M.K .Singh is assistant dean, Health Systems Science, and associate professor of medicine, Case Western Reserve University School of Medicine and Department of Veterans Affairs Louis Stokes Medical Center, Cleveland, Ohio. L. Davies is associate professor, Section of Otolaryngology-Head & Neck Surgery, and the Dartmouth Institute, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire; and associate professor, Department of Veterans Affairs Medical Center, White River Junction, Vermont.

The SQUIRE 2.0 (Standards for QUality Improvement Reporting Excellence) guidelines were published in 2015 to increase the completeness, precision, and transparency of published reports about efforts to improve the safety, value, and quality of health care. The principles and methods applied in work to improve health care are often applied in educational improvement as well. Read More

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http://dx.doi.org/10.1097/ACM.0000000000002750DOI Listing

Response: Comment on "Guideline Assessment Project: Filling the GAP in Surgical Guidelines: Quality Improvement Initiative by an International Working Group".

Ann Surg 2019 Apr 13. Epub 2019 Apr 13.

European Association for Endoscopic Surgery Consensus and Guideline Subcommittee, Eindhoven, Netherlands Department of Surgery, European University Cyprus, Nicosia, Cyprus Department of Vascular and Endovascular Surgery, The Royal Oldham Hospital, Pennine Acute Hospitals NHS Trust, Manchester, UK Division of Cardiovascular Sciences, School of Medical Sciences, University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1097/SLA.0000000000003319DOI Listing

Bifidobacterium longum 1714™ Strain Modulates Brain Activity of Healthy Volunteers During Social Stress.

Am J Gastroenterol 2019 Apr 17. Epub 2019 Apr 17.

Department of Psychosomatic Medicine and Psychotherapy, University of Tübingen, Tübingen, Germany.

Objectives: Accumulating evidence indicates that the gut microbiota communicates with the central nervous system, possibly through neural, endocrine, and immune pathways, and influences brain function. B. longum 1714™ has previously been shown to attenuate cortisol output and stress responses in healthy subjects exposed to an acute stressor. Read More

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http://dx.doi.org/10.14309/ajg.0000000000000203DOI Listing

Study of Knowledge, Attitudes, and Practices Toward Risk Factors and Early Detection of Noncommunicable Diseases Among Rural Women in India.

J Glob Oncol 2019 Apr(5):1-10

3 International Agency for Research on Cancer, Lyon, France.

Purpose: In recognition of the growing burden of noncommunicable diseases (NCDs), including cancer, we assessed the knowledge, attitudes, and practices of rural women in low-resourced countries toward common NCDs and the barriers they face in receiving NCD early detection services.

Patients And Methods: The study was conducted in a rural block of India using the Rapid Assessment and Response Evaluation ethnographic assessment, which included in-depth interviews of key health officials; focus group discussions with women, men, teachers, and health workers from the block; and a knowledge, attitudes, and practices questionnaire survey. The home-based survey was conducted among 1,192 women selected from 50 villages of the block using a two-stage randomization process and stratified to 30- to 44-year and 45- to 60-year age-groups. Read More

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http://dx.doi.org/10.1200/JGO.18.00181DOI Listing

Meeting Overview: Interferon Lambda-Disease Impact and Therapeutic Potential.

J Interferon Cytokine Res 2019 Apr 17. Epub 2019 Apr 17.

4 Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.

A meeting entitled, "Interferon Lambda: Disease Impact and Translational Potential," was held on the campus of the National Institutes of Health in Bethesda, Maryland, on October 25-26, 2018. To our knowledge, this was the first meeting that focused exclusively on interferon lambda (IFN-λ). The meeting's purpose was to enhance interdisciplinary communication and promote new collaborations. Read More

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http://dx.doi.org/10.1089/jir.2019.0018DOI Listing

Changes in State Technical Assistance Priorities and Block Grant Funds for Addiction After ACA Implementation.

Am J Public Health 2019 Apr 18:e1-e7. Epub 2019 Apr 18.

Amanda J. Abraham is with the School of Public and International Affairs, University of Georgia, Athens. Bikki Tran Smith, Colleen M. Grogan, and Harold A. Pollack are with the School of Social Service Administration, University of Chicago, Chicago, IL. Christina M. Andrews is with the College of Social Work, University of South Carolina, Columbia. Clifford S. Bersamira is with the Myron B. Thompson School of Social Work, University of Hawai'i at Mānoa, Honolulu. Peter D. Friedmann is with the University of Massachusetts Medical School Baystate, Springfield.

To assess states' provision of technical assistance and allocation of block grants for treatment, prevention, and outreach after the expansion of health insurance coverage for addiction treatment in the United States under the Affordable Care Act (ACA). We used 2 waves of survey data collected from Single State Agencies in 2014 and 2017 as part of the National Drug Abuse Treatment System Survey. The percentage of states providing technical assistance for cross-sector collaboration and workforce development increased. Read More

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http://dx.doi.org/10.2105/AJPH.2019.305052DOI Listing

Effect of Text Messaging on Risk Factor Management in Patients With Coronary Heart Disease.

Circ Cardiovasc Qual Outcomes 2019 Apr;12(4):e005616

Center for Outcomes Research and Evaluation, Yale-New Haven Hospital, New Haven, CT (E.S.S., Q.D., H.M.K.).

Background: Mobile health technologies are low cost, scalable interventions with the potential to promote patient engagement and behavior change. We aimed to test whether a culturally sensitive text messaging intervention supporting secondary prevention improves the control of risk factors in patients with coronary heart disease in China.

Methods And Results: In this multicenter, single-blinded randomized controlled trial, 822 patients (mean age, 56. Read More

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https://www.ahajournals.org/doi/10.1161/CIRCOUTCOMES.119.005
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http://dx.doi.org/10.1161/CIRCOUTCOMES.119.005616DOI Listing
April 2019
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Selecting household water treatment options on the basis of World Health Organization performance testing protocols.

Environ Sci Technol 2019 Apr 18. Epub 2019 Apr 18.

The World Health Organization's International Scheme to Evaluate Household Water Treatment Technologies serves to benchmark microbiological performance of existing and novel technologies and processes for small-scale drinking water treatment according to a tiered system. There is widespread uncertainty around which tiers of performance are most appropriate for technology selection and recommendation in humanitarian response or for routine safe water programming. We used quantitative microbial risk assessment (QMRA) to evaluate attributable reductions in diarrheal disease burden associated with water treatment technologies meeting the three tiers of performance under this Scheme, across a range of conditions. Read More

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http://dx.doi.org/10.1021/acs.est.8b05682DOI Listing

Phenothiazine-Based Organic Catholyte for High-Capacity and Long-Life Aqueous Redox Flow Batteries.

Adv Mater 2019 Apr 18:e1901052. Epub 2019 Apr 18.

Materials Science and Engineering Program and Department of Mechanical Engineering, The University of Texas at Austin, Austin, TX, 78712, USA.

Redox-active organic materials have been considered as one of the most promising "green" candidates for aqueous redox flow batteries (RFBs) due to the natural abundance, structural diversity, and high tailorability. However, many reported organic molecules are employed in the anode, and molecules with highly reversible capacity for the cathode are limited. Here, a class of heteroaromatic phenothiazine derivatives is reported as promising positive materials for aqueous RFBs. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/adma.2019010
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http://dx.doi.org/10.1002/adma.201901052DOI Listing
April 2019
1 Read

The influence of delay elimination communication on the prevalence of primary nocturnal enuresis-a survey from Mainland China.

Neurourol Urodyn 2019 Apr 18. Epub 2019 Apr 18.

Pediatric Urodynamic Centre, Urology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Aims: A pilot survey shows that primary nocturnal enuresis (PNE) prevalence has increased significantly during the past decade in Mainland China. Whether it is related to the delay of elimination communication (EC) is unclear. This study retrospectively investigated the influence of delayed EC on the PNE prevalence in children and adolescents in mainland China. Read More

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http://dx.doi.org/10.1002/nau.24002DOI Listing
April 2019
2.873 Impact Factor

Longitudinal Examination of Fellow-Eye Vascular Anomalies in Coats' Disease With Widefield Fluorescein Angiography: A Multicenter Study.

Ophthalmic Surg Lasers Imaging Retina 2019 Apr;50(4):221-227

Background And Objective: Retinovascular anomalies in the fellow eyes of patients with Coats' disease have been described, but the clinical significance is unknown, as well as whether these lesions progress over time.

Patients And Methods: This is an international, multicenter, retrospective, observational cohort study of fellow-eye abnormalities on widefield fluorescein angiography in patients with Coats' disease.

Results: Three hundred fifty eyes of 175 patients with Coats' disease were analyzed. Read More

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http://dx.doi.org/10.3928/23258160-20190401-04DOI Listing

Effectiveness of Low Glycemic Index Diet Consultations Through a Diet Glycemic Assessment App Tool on Maternal and Neonatal Insulin Resistance: A Randomized Controlled Trial.

JMIR Mhealth Uhealth 2019 Apr 18;7(4):e12081. Epub 2019 Apr 18.

Children's Hospital of Fudan University, Shanghai, China.

Background: Low glycemic index (LGI) diet has shown to be effective in reducing maternal and neonatal complications in high-risk pregnancies.

Objective: This trial aimed to examine the effectiveness of individualized LGI diet consultations based on the accurate diet glycemic load (GL) assessment tool on maternal and neonatal insulin resistance levels and diet behavior changes in overweight and obese pregnant women.

Methods: Overweight and obese pregnant women were recruited before 16 weeks of gestation and randomized to the LGI diet arm or the control arm. Read More

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http://dx.doi.org/10.2196/12081DOI Listing

The Potential of Self-Management mHealth for Pediatric Cystic Fibrosis: Mixed-Methods Study for Health Care and App Assessment.

JMIR Mhealth Uhealth 2019 Apr 18;7(4):e13362. Epub 2019 Apr 18.

Instituto ITACA, Universitat Politècnica de València, Valencia, Spain.

Background: Remote care services and patient empowerment have boosted mobile health (mHealth). A study of user needs related to mHealth for pediatric cystic fibrosis (PCF) identified the set of preferred features mobile apps should support; however, the potential use of PCF apps and their suitability to fit into PCF clinical management remains unexplored.

Objective: We examine whether PCF holds potential for the implementation of mHealth care. Read More

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http://dx.doi.org/10.2196/13362DOI Listing

Reducing Alcohol Consumption Among Risky Drinkers in the General Population of Sweden Using an Interactive Mobile Health Intervention: Protocol for a Randomized Controlled Trial.

JMIR Res Protoc 2019 Apr 18;8(4):e13119. Epub 2019 Apr 18.

Department of Health Sciences, University of York, York, United Kingdom.

Background: Harmful use of alcohol continues to be a leading contributor to premature deaths globally. Not only does harmful drinking have consequences for the individuals consuming at increased levels, but it may also result in a range of negative consequences for their family members and friends. Interventions delivered via mobile phones (mobile health [mHealth] interventions) could potentially support risky drinkers seeking help to reduce their alcohol consumption. Read More

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http://dx.doi.org/10.2196/13119DOI Listing

Implementing Web-Based Interventions in HIV Primary Care Clinics: Pilot Implementation Evaluation of Positive Health Check.

JMIR Form Res 2019 Apr 18;3(2):e10688. Epub 2019 Apr 18.

Center for Communication Science, RTI International, Durham, NC, United States.

Background: Web-based interventions can help people living with HIV achieve better clinical outcomes and behaviors, but integrating them into clinical practice remains challenging. There is a gap in understanding the feasibility of implementing these interventions in HIV clinic settings from the clinicians' perspective.

Objective: The goal of the research was to determine whether Positive Health Check (PHC)-a Web-based, tailored video counseling tool focused on increasing patient adherence and retention in care and reducing HIV risk among HIV-positive patients-was acceptable, appropriate, and feasible for HIV primary care clinic staff to implement in clinic workflows. Read More

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http://dx.doi.org/10.2196/10688DOI Listing

[Effects of Low-Dose Decitabine on Soluble CD44, GDF11 Levels and Hematopoietic Function in Elderly Patients with MDS].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2019 Apr;27(2):509-514

Department of Hematology, Hengshui Harrison International Peace Hospital, Hengshui 053000, Hebei Province, China,E-mail:

Objective: To investigate the effects of low-dose decitabine on levels of soluble CD44 and GDF11, and hematopoietic function in elderly patients with myelodysplastic syndrome (MDS).

Methods: Ninety-nine patients with senile myelodysplastic syndrome (MDS) admitted to our hospital from October 2015 to October 2017 were divided into group A, B and C according to their treatment, each with 33 cases.The patients in group A were treated with low-dose decitabine, the patients in group B were treated with usual dose of decitabine, and the patients in group C were treated with low-dose decitabine plus G-GSF, cytarabine, and aclarithromycin. Read More

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http://dx.doi.org/10.19746/j.cnki.issn.1009-2137.2019.02.032DOI Listing

[Value of MYC, BCL-2 and BCL-6 for Evaluation of Prognosis in Patients with Diffuse Large B Cell Lymphoma].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2019 Apr;27(2):452-457

Department of Hematology, Hainan Provincial People's Hospital, Haikou 571100, Hainan Province, China.

Objective: To analyze the prognostic value of BCL-2, BCL-6 and MYC in patients with diffuse large B cell lymphoma (DLBCL).

Methods: One hundred and sixty three cases of DLBCL in our hospital from March 2012 to March 2015 were selected. The specimens of lymphoma tissue of patients were collected. Read More

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http://dx.doi.org/10.19746/j.cnki.issn.1009-2137.2019.02.023DOI Listing

[E-cadherin Expression in Children with Acute Leukemia and Its Clinical Significance].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2019 Apr;27(2):339-347

Department of Hematology & Oncology, Childhren's Hospital Affiliated to Chongqing Medical University; Key Laboratory of Child Development and Disorders of Ministry of Education; China International Science and Technology Cooperation Base of Child Development and Critical Disorders; Chongqing Key Laboratory of Pediatrics, Chongqing 400014, China,E-mail:

Objective: To investigate the correlation of E-cadherin expression level with the clinical characterastics in children with acute leukemia (AL), and to explore the possible regulatory mechanism.

Methods: Real-time quantitative RT-PCR was applied to detect the expression level of E-cadherin in bone marrow samples from 135 child patients diagnosed as AL, and its relevance with clinical indicators was statistically analyzed. The expression levels of E-cadherin, β-catenin, and Akt/p-Akt were detected by using Western blot. Read More

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http://dx.doi.org/10.19746/j.cnki.issn.1009-2137.2019.02.005DOI Listing

Cognitive workload measurement and modeling under divided attention.

J Exp Psychol Hum Percept Perform 2019 Apr 18. Epub 2019 Apr 18.

Division of Psychology, University of Tasmania.

Motorists often engage in secondary tasks unrelated to driving that increase cognitive workload, resulting in fatal crashes and injuries. An International Standards Organization method for measuring a driver's cognitive workload, the detection response task (DRT), correlates well with driving outcomes, but investigation of its putative theoretical basis in terms of finite attention capacity remains limited. We address this knowledge gap using evidence-accumulation modeling of simple and choice versions of the DRT in a driving scenario. Read More

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http://dx.doi.org/10.1037/xhp0000638DOI Listing

Mediterranean diet during pregnancy and childhood for asthma in children: A systematic review and meta-analysis of observational studies.

Pediatr Pulmonol 2019 Apr 17. Epub 2019 Apr 17.

Respiratory Department, Children's Hospital of Chongqing Medical University, Chongqing, China.

Objectives: To evaluate the relationship between high adherence to the Mediterranean diet in pregnancy and childhood and the risk of asthma and wheeze in children.

Methods: We conducted searches of PubMed, EMBASE, and Cochrane Central Register of Controlled Trials from inception to 30 October 2018. Observational studies providing risk estimates and corresponding confidence intervals on the association of high adherence to the Mediterranean diet in pregnancy or childhood and the risk of asthma or wheeze in childhood were included. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/ppul.24338
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http://dx.doi.org/10.1002/ppul.24338DOI Listing
April 2019
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Surface Charge-Reversible Tubular Micromotors for Extraction of Nucleic Acids in Microsystems.

Chem Asian J 2019 Apr 17. Epub 2019 Apr 17.

Wuhan University of Technology, 122 Luoshi road, Wuhan, CHINA.

Extraction of nucleic acids in microsystems is of significance for biomedical applications, but the current extraction methods generally require sophisticated microchannels and external equipment, hindering their practical applications. In this work, we have demonstrated a simple, versatile and efficient approach to extract nucleic acids in microsystems by developing cationic branched polyethyleneimine (PEI)-functionalized tubular micromotors. The as-developed tubular micromotors are fabricated by a two-step process combining the template-assisted electrodeposition and carbodiimide chemistry, and contain an inner catalytic Pt layer, a middle magnetic Ni layer and an outer cationic PEI layer. Read More

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http://dx.doi.org/10.1002/asia.201900427DOI Listing
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