497,128 results match your criteria International journal of pediatric obesity : IJPO : an official journal of the International Association for the Study of Obesity[Journal]


[Complications of transperineal template-guided prostate mapping biopsy].

Zhonghua Yi Xue Za Zhi 2019 Feb;99(6):428-431

Department of Urology, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou 225001, China.

To assess the complications of transperineal template-guided prostate mapping biopsy (TTMB). Between May 2017 and March 2018, 142 consecutive patients with prior negative transrectal biopsy results and persistently elevated prostate-specific antigen (PSA) were divided into the observation group and the control group randomly. The observation group underwent TTMB and the control group underwent transperineal template-guided prostate saturation biopsy (TTSB). Read More

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2019.06.009DOI Listing
February 2019

[Comparative observation of thulium laser resection of the prostate-tangerine technique and transurethral resection of the prostate for the treatment of benign prostatic hyperplasia of various sizes].

Zhonghua Yi Xue Za Zhi 2019 Feb;99(6):423-427

Department of Urology, Guizhou Provincial People's Hospital, Guiyang 550002, China.

To compare the efficiency and safety of thulium laser resection of the prostate-tangerine technique (TmLRP-TT) and transurethral resection of the prostate (TURP) for the treatment of benign prostatic hyperplasia (BPH) of various sizes. Clinical data of 249 BPH patients received TmLRP-TT or TURP were retrospectively collected. Patients were divided into small prostate group [prostate volume (PV)<40 ml], medium prostate group (40 ml≤PV<80 ml) and large prostate group (PV ≥ 80 ml) based on transrectal ultrasound (TRUS) results. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2019.06.008DOI Listing
February 2019

An International Summit in Human Genetics and Genomics: Empowering clinical practice and research in developing countries.

Mol Genet Genomic Med 2019 Jan;7(1):e00599

National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland.

To help fill the knowledge gap in human genetics and genomics, an International Summit (IS) in Human Genetics and Genomics was conceived and organized by the National Human Genome Research Institute (NHGRI) of the National Institutes of Health (NIH) as a 5-year initiative, from 2016 to 2020. In its first 3 years, 71 professionals from 34 countries received training. Read More

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http://dx.doi.org/10.1002/mgg3.599DOI Listing
January 2019

Intensity-modulated radiation therapy dose prescription and reporting: Sum and substance of the International Commission on Radiation Units and Measurements Report 83 for veterinary medicine.

Vet Radiol Ultrasound 2019 Feb 20. Epub 2019 Feb 20.

Division of Radiation Oncology, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland.

Institutions' adherence to protocol, quality assurance, and radiation parameter reporting are key to adequately interpret and compare treatment outcomes in radiation oncology. In 2017, the editorial board for Veterinary Radiology & Ultrasound adapted author guidelines on "technical information for radiation therapy (RT)". These guidelines provide a framework to report the RT treatment process in manuscripts resulting from veterinary clinical trials. Read More

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http://dx.doi.org/10.1111/vru.12722DOI Listing
February 2019

International Federation of Gynecology and Obstetrics Global Declaration on Cervical Cancer Elimination.

Authors:

Rev Bras Ginecol Obstet 2019 Feb 20;41(2):102-103. Epub 2019 Feb 20.

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http://dx.doi.org/10.1055/s-0039-1679865DOI Listing
February 2019

Using Electronic Health Records to Identify Adverse Drug Events in Ambulatory Care: A Systematic Review.

Appl Clin Inform 2019 Jan 20;10(1):123-128. Epub 2019 Feb 20.

Department of Global Biostatistics and Data Science, Tulane University School of Public Health and Tropical Medicine, Tulane University, New Orleans, Louisiana, United States.

Objective:  We identified the methods used and determined the roles of electronic health records (EHRs) in detecting and assessing adverse drug events (ADEs) in the ambulatory setting.

Methods:  We performed a systematic literature review by searching PubMed and Google Scholar for studies on ADEs detected in the ambulatory setting involving any EHR use published before June 2017. We extracted study characteristics from included studies related to ADE detection methods for analysis. Read More

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http://dx.doi.org/10.1055/s-0039-1677738DOI Listing
January 2019

International Divergence in Gene Patenting.

Annu Rev Genomics Hum Genet 2019 Feb 20. Epub 2019 Feb 20.

Centre for IT and IP Law, KU Leuven, 3000 Leuven, Belgium.

This review explores the recent divergence in international patent law relating to the patenting of genes and related subject matter. This divergence stems primarily from decisions of the highest courts in the United States and Australia on the eligibility of patent claims relating to the BRCA gene sequences. Patent offices, courts, and policy makers have struggled for many years to clearly articulate the bounds of patent claims on isolated and synthetic DNA and related products and processes, including methods for their use in genetic diagnostics. Read More

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http://dx.doi.org/10.1146/annurev-genom-083118-015112DOI Listing
February 2019

The FDA's Proposed Ban on Menthol Cigarettes.

Authors:
Keith Wailoo

N Engl J Med 2019 Feb 20. Epub 2019 Feb 20.

From the Woodrow Wilson School of Public and International Affairs, Princeton University, Princeton, NJ.

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http://dx.doi.org/10.1056/NEJMp1900204DOI Listing
February 2019

Increase of germ cell nuclear factor expression in globozoospermic Gopc knockout mice.

Andrology 2019 Feb 20. Epub 2019 Feb 20.

Department of Cell Biology and Histology, School of Medicine and Nursing, University of the Basque Country (UPV/EHU), Leioa, Spain.

Background: Golgi-associated PDZ and coiled-coil motif-containing protein (GOPC) is a Golgi protein that plays a role in vesicular transport and intracellular protein trafficking and degradation. Mice deficient in GOPC protein have globozoospermia and are infertile. The germ cell nuclear factor (GCNF) is a member of the nuclear receptor superfamily which is expressed in male germ cells, from spermatocytes and spermatids, both in the nucleus and the acrosomal region. Read More

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http://dx.doi.org/10.1111/andr.12594DOI Listing
February 2019

Disparities in the delivery of pediatric oncology nursing care by country income classification: International survey results.

Pediatr Blood Cancer 2019 Feb 20:e27663. Epub 2019 Feb 20.

Department of Global Pediatric Medicine, St Jude Children's Research Hospital, Memphis, Tennessee.

Background: In 2014, a task force of the International Society of Paediatric Oncology (SIOP) Paediatric Oncology in Developing Countries Nursing Workgroup published six baseline standards to provide a framework for pediatric oncology nursing care in low- and lower-middle income countries (L/LMIC). We conducted an international survey in 2016-2017 to examine the association between country income level and nurses' resporting of conformity to the standards at their respective institutions.

Procedure: Data from a cross-sectional web-based survey completed by nurses representing 54 countries were analyzed (N = 101). Read More

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http://dx.doi.org/10.1002/pbc.27663DOI Listing
February 2019

Recent Advances of MOF-Derived Nanoporous Carbon Materials.

Chem Asian J 2019 Feb 20. Epub 2019 Feb 20.

Australian Institute for Bioengineering and Nanotechnology (AIBN), The University of Queensland, Brisbane, QLD 4072, Australia, AUSTRALIA.

Metal-organic frameworks (MOFs)-derived nanoporous carbon materials have received significant interest due to their advantages of controllable porosity, good thermal/chemical stability, high electrical conductivity, catalytic activity, easy modification with other elements and materials, etc. Thus, MOF-derived carbons have been used in numerous applications such as environment, energy storage systems (i.e. Read More

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http://doi.wiley.com/10.1002/asia.201900026
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http://dx.doi.org/10.1002/asia.201900026DOI Listing
February 2019
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Validation of an MPC Polymer Coating to Attenuate Surface-Induced Crosstalk between the Complement and Coagulation Systems in Whole Blood in In Vitro and In Vivo Models.

Macromol Biosci 2019 Feb 20:e1800485. Epub 2019 Feb 20.

Department of Immunology, Genetics and Pathology, Uppsala University, Dag Hammarskjölds väg 20, SE-751 85, Uppsala, Sweden.

Artificial surfaces that come into contact with blood induce an immediate activation of the cascade systems of the blood, leading to a thrombotic and/or inflammatory response that can eventually cause damage to the biomaterial or the patient, or to both. Heparin coating has been used to improve hemocompatibility, and another approach is 2-methacryloyloxyethyl phosphorylcholine (MPC)-based polymer coatings. Here, the aim is to evaluate the hemocompatibility of MPC polymer coating by studying the interactions with coagulation and complement systems using human blood in vitro model and pig in vivo model. Read More

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http://dx.doi.org/10.1002/mabi.201800485DOI Listing
February 2019

Correction of pulmonary hypertension with intensive hemodialysis: A case report.

Hemodial Int 2019 Feb 20. Epub 2019 Feb 20.

Division of Nephrology, University Health Network, Toronto, Canada.

Pulmonary hypertension (PH) defined as a mean pulmonary arterial pressure ≥25 mmHg is a common complication in hemodialysis occurring in up to 58% of patients. PH is classified according to its etiology. We report in a patient with severe PH of mixed etiology (connective tissue disease and left-sided heart failure) who improved after initiation of intensive home hemodialysis. Read More

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http://dx.doi.org/10.1111/hdi.12691DOI Listing
February 2019

Expectations and experiences of nursing students in supporting new mothers to breastfeed: A descriptive qualitative study.

J Clin Nurs 2019 Feb 20. Epub 2019 Feb 20.

Western Sydney University, School of Nursing and Midwifery, Locked Bag 1797, Penrith, NSW, 2751.

Background: Improving breastfeeding support to mothers has been the focus of several national and international health organizations. There is evidence that theoretical and clinical education improves breastfeeding knowledge and attitudes among nursing and other health professional students prior to clinical placement, to support women who are breastfeeding.

Aims And Objectives: To explore the expectations and experiences of Taiwanese nursing students in supporting breastfeeding on clinical placement. Read More

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http://dx.doi.org/10.1111/jocn.14836DOI Listing
February 2019

Stiffness-Changing of Polymer Nanocomposites with Cellulose Nanocrystals and Polymeric Dispersant.

Macromol Rapid Commun 2019 Feb 20:e1800910. Epub 2019 Feb 20.

Adolphe Merkle Institute, University of Fribourg, Chemin des Verdiers 4, CH-1700, Fribourg, Switzerland.

Bio-inspired, water-responsive, mechanically adaptive nanocomposites are reported based on cellulose nanocrystals (CNCs), poly(ethylene oxide-co-epichlorohydrin) (EO-EPI), and a small amount of poly(vinyl alcohol) (PVA), which is added to aid the dispersion of the CNCs. In the dry state, the CNCs form a reinforcing network within the polymer matrix, and the substantial stiffness increase relative to the neat polymer is thought to be the result of hydrogen-bonding interactions between the nanocrystals. Exposure to water, however, causes a large stiffness reduction, due to competitive hydrogen bonding of water molecules and the CNCs. Read More

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http://dx.doi.org/10.1002/marc.201800910DOI Listing
February 2019

mHDFS-HoF: A generalized multilevel homodesmotic fragment-separation reaction based program for heat-of-formation calculation for acyclic hydrocarbons.

J Comput Chem 2019 Feb 20. Epub 2019 Feb 20.

Chemical Engineering Department, International University, VNU-HCM, Vietnam.

Based on our modified classification of elemental species, a framework for automatic generation of multilevel Homodesmotic fragment-separation (mHDFS) reactions for chemical species was proposed. Combined the mHDFS framework with a database of heat of formation (HoF) and the calculated electronic structure data for the elemental mHD species, the mHDFS-HoF program was constructed in C/C++ language to calculate heat of formation for a species of interest on-the-fly. Using the electronic structure data calculated at CBS-QB3 level of theory for the elemental mHD species, applications and robustness of the code were discussed with several acyclic hydrocarbon systems including neutral and radical species. Read More

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http://dx.doi.org/10.1002/jcc.25790DOI Listing
February 2019

Epidemiology and resource utilization of ludwig angina ED visits in the United States 2006-2014.

Laryngoscope 2019 Feb 20. Epub 2019 Feb 20.

Department of Surgery, Division of Otolaryngology/Head & Neck Surgery, Howard University College of Medicine, Washington, District of Columbia, U.S.A.

Objectives: Ludwig angina is a potentially lethal submandibular space infection. We aim to describe the epidemiological characteristics of Ludwig angina patients presenting to the emergency department (ED) and to examine outcomes and resource utilization to determine their burden on ED and hospitals.

Methods: Using the Nationwide Emergency Department Sample database, a nationally representative all-payer database, we retrospectively reviewed all ED visits between 2006 and 2014 for patients admitted with a primary diagnosis of Ludwig angina (International Classification of Diseases, Ninth Revision, 528. Read More

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http://dx.doi.org/10.1002/lary.27734DOI Listing
February 2019

Identification of a new inhibitor of KRAS-PDEδ interaction targeting KRAS mutant non-small cell lung cancer.

Int J Cancer 2019 Feb 20. Epub 2019 Feb 20.

State Key Laboratory of Quality Research in Chinese Medicine/Macau Institute For Applied Research in Medicine and Health, Macau University of Science and Technology, Avenida Wai Long, Taipa, Macau (SAR), China.

Oncogenic KRAS is considered a promising target for anti-cancer therapy. However, direct pharmacological strategies targeting KRAS-driven cancers remained unavailable. The prenyl-binding protein PDEδ, a transporter of KRAS, has been identified as a potential target for pharmacological inhibitor by selectively binding to its prenyl-binding pocket, impairing oncogenic KRAS signaling pathway. Read More

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http://dx.doi.org/10.1002/ijc.32222DOI Listing
February 2019

NK007 helps in mitigating paclitaxel resistance through p38MAPK activation and HK2 degradation in ovarian cancer.

J Cell Physiol 2019 Feb 20. Epub 2019 Feb 20.

The First Affiliated Hospital, Biomedical Translational Research Institute and School of Pharmacy, Jinan University, Guangzhou, China.

Ovarian cancer resistance to available medicines is a huge challenge in dire need of a solution, which makes its recurrence and mortality rate further exacerbated. A promising approach to overcome chemoresistance is drug screening from natural products. Here, we report that NK007, a (±)-tylophorine malate isolated from the Asclepiadaceae family, selectively inhibited the proliferation of A2780 and A2780 (Taxol) cells and migration of paclitaxel-sensitive and -resistant ovarian cancer cells. Read More

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http://dx.doi.org/10.1002/jcp.28278DOI Listing
February 2019

[The content of publications in the Netherlands Journal of Dentistry - an analysis of patterns over time].

Ned Tijdschr Tandheelkd 2019 Feb;126(2):91-100

In 2018, the Netherlands Journal of Dentistry (NTVT) had been published for 125 years: reason for a systematic look at the subjects that have received attention since 2000. These subjects were subsequently compared to those in Dutch dental publications in international literature and to leading fields in oral health care. The analysis revealed an increase in the attention given to certain fields in the Netherlands Journal of Dentistry, such as public dental health, during the past 18 years and a decrease in the attention given to other subjects, such as basic scientific research. Read More

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http://dx.doi.org/10.5177/ntvt.2019.02.18242DOI Listing
February 2019

[Epidemiological study of mental health in the general population of Argentina].

Vertex 2018 Nov;XXIX(142):275-299

Departamento de Psiquiatría y Salud Mental, Facultad de Medicina, Universidad de Buenos Aires, Argentina.

In this paper we report the findings of the first "Epidemiological study of mental health in the general population of Argentina" in the framework of the World Mental Health Survey Initiative WHO / Harvard, in collaboration with the Faculty of Medicine of the University of Buenos Aires and the Asociación de Psiquiatras Argentinos (APSA) with funding from the Ministry of Health. Methodology: A multistage probabilistic household survey was conducted using the Composite International Diagnostic Interview (CIDI). The survey was conducted on 3,927 people aged 18 and over (no age limit), with fixed residence in one of the eight largest urban areas in the country (Buenos Aires, Córdoba, Corrientes-Resistencia, Mendoza, Neuquén, Rosario, Salta and Tucumán), representing approximately 50. Read More

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November 2018

Evaluation of hemostasis in patients with end-stage renal disease.

PLoS One 2019 20;14(2):e0212237. Epub 2019 Feb 20.

Department of General, Visceral and Transplant Surgery, University Hospital Essen, University Duisburg-Essen, Essen, Germany.

An increased bleeding risk is reported for patients with end-stage renal disease. This study aims to analyze, whether bleeding risk can be assessed by global tests of hemostasis. Standard laboratory tests and an extended evaluation of hemostasis by rotational thromboelastometry, platelet function analyzer (PFA) and multiple electrode aggregometry as well as thrombin generation assays and measurement of fibrinolytic potential were performed in 20 patients on hemodialysis, 10 patients on peritoneal dialysis, 10 patients with chronic kidney disease stage G5 (CKD5) and in 10 healthy controls (HC). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212237PLOS
February 2019

Transition to middle school: Self-concept changes.

PLoS One 2019 20;14(2):e0212640. Epub 2019 Feb 20.

Department of Physical Education and Sports, University of Granada, Granada, Spain.

Self-concept influences identity and the way that people behave, and it fluctuates over time. The main purpose of this study was to analyze fluctuations in the dimensions of self-concept as a function of gender, educational level, grade, age, physical activity, and weight. In total, 712 Spanish adolescents who were in the 5th and 8th grades (354 boys and 358 girls) and 10 to 14 years old (M = 11. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212640PLOS
February 2019

Towards a universal concept of vulnerability: Broadening the evidence from the elderly to perinatal health using a Delphi approach.

PLoS One 2019 20;14(2):e0212633. Epub 2019 Feb 20.

Public Health, Environmental and Social Determinants of Health Department (PHE), World Health Organization, Geneva, Switzerland.

Background: The concept 'vulnerability' is prevalent in the public domain, health care, social institutions and multidisciplinary research. Conceptual heterogeneity is present, hampering the creation of a common evidence-base of research achievements and successful policies. Recently an international expert group combined a specific literature review with a 2-stage Delphi procedure, arriving at a seemingly universal concept of vulnerability for the elderly with applications for research instruments. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212633PLOS
February 2019

Access to and price trends of antidiabetic, antihypertensive, and antilipidemic drugs in outpatient settings of the Universal Coverage Scheme in Thailand.

PLoS One 2019 20;14(2):e0211759. Epub 2019 Feb 20.

Department of Clinical Pharmacy, Faculty of Pharmacy, Mahasarakham University, Mahasarakham, Thailand.

Under the Universal Coverage Scheme (UCS) with payment per capita for outpatient (OP) services, hospitals' financial risks will rise if access to essential drugs increases. This study examined trends in access to and price of essential drugs for noncommunicable diseases (NCDs) and an overall purchasing price index (PPI) for an OP drug basket from public hospitals. To examine drug access, OP prescription data from 2010-2012 were obtained from the UCS. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211759PLOS
February 2019
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Surgical management of intraocular lens dislocation: A meta-analysis.

PLoS One 2019 20;14(2):e0211489. Epub 2019 Feb 20.

Department of Ophthalmology, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China.

Purpose: To compare the efficacy and safety of intraocular lens (IOL) repositioning and IOL exchange for the treatment of patients with IOL dislocation.

Methods: We systematically searched for relevant publications in English or Chinese in MEDLINE, Embase, the Cochrane Central Register of Controlled Trials, WHO International Clinical Trial Registration Platform, Clinical Trial.gov, China Biology Medicine Database, China National Knowledge Infrastructure Database and grey literature sources. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211489PLOS
February 2019

Averting wheat blast by implementing a 'wheat holiday': In search of alternative crops in West Bengal, India.

PLoS One 2019 20;14(2):e0211410. Epub 2019 Feb 20.

Socioeconomics Program, CIMMYT (International Maize and Wheat Improvement Center), Texcoco, México.

The emergence of wheat-blast in Bangladesh in the 2015-16 wheat (Triticum aestivum L.) crop threatens the food security of South Asia. A potential spread of the disease from Bangladesh to India could have devastating impacts on India's overall food security as wheat is its second most important staple food crop. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211410PLOS
February 2019

Efficient design and analysis of randomized controlled trials in rare neurological diseases: An example in Guillain-Barré syndrome.

PLoS One 2019 20;14(2):e0211404. Epub 2019 Feb 20.

Centre for Medical Decision Making, Department of Public Health, Erasmus University Medical Center, Rotterdam, The Netherlands.

Background: Randomized controlled trials (RCTs) pose specific challenges in rare and heterogeneous neurological diseases due to the small numbers of patients and heterogeneity in disease course. Two analytical approaches have been proposed to optimally handle these issues in RCTs: covariate adjustment and ordinal analysis. We investigated the potential gain in efficiency of these approaches in rare and heterogeneous neurological diseases, using Guillain-Barré syndrome (GBS) as an example. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211404PLOS
February 2019

Oil palm plantations in Peninsular Malaysia: Determinants and constraints on expansion.

PLoS One 2019 20;14(2):e0210628. Epub 2019 Feb 20.

Department of Geographical Sciences, University of Maryland, College Park, Maryland, United States of America.

Agricultural expansion is one of the leading causes of deforestation in the tropics and in Southeast Asia it is predominantly driven by large-scale production for international trade. Peninsular Malaysia has a long history of plantation agriculture and has been a predominantly resource-based economy where expanding plantations like those of oil palm continue to replace natural forests. Habitat loss from deforestation and expanding plantations threatens Malaysian biodiversity. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0210628PLOS
February 2019

Non-communicable diseases and tuberculosis: Anticipating the impending global storm.

Glob Public Health 2019 Feb 20:1-10. Epub 2019 Feb 20.

e Medecins du Monde , Athens , Greece.

The epidemiological transitions that have occurred in low and middle income countries (LMIC) during the past decades have led to an increased prevalence on non-communicable diseases (NCDs) in these countries, where the burden of infectious diseases (IDs), especially tuberculosis (TB), remains high. Although the true dimensions of this comorbidity have not yet been fully understood, there is a growing amount of data, over the last 10 years, that suggest a clear association between NCDs and TB. In particular, there is a continuously increasing body of evidence that diabetes mellitus, chronic respiratory conditions, tobacco use, mental health illnesses and chronic kidney disease increase TB morbidity and mortality and vice versa. Read More

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http://dx.doi.org/10.1080/17441692.2019.1580760DOI Listing
February 2019

High Rate of Serotype Switching and Genetic Variations Indicates Widespread Recombination Between Clinical and Commensal Penicillin-Nonsusceptible Streptococcus pneumoniae in Tehran.

Microb Drug Resist 2019 Feb 20. Epub 2019 Feb 20.

3 Department of Microbiology, Pasteur Institute of Iran, Tehran, Iran.

A total of 161 Streptococcus pneumoniae were collected between 2013 and 2015 in Tehran, Iran. The strains were tested for antimicrobial susceptibility and minimum inhibitory concentrations, serotyped, and genotyped by multilocus sequence typing (MLST) and pulsed-field gel electrophoresis (PFGE). Penicillin-binding proteins (PBPs) were also typed by restriction fragment length polymorphism (PBP-RFLP). Read More

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http://dx.doi.org/10.1089/mdr.2018.0336DOI Listing
February 2019

Care for dementia patients at the end of life.

Authors:
Laura Glenny

Int J Palliat Nurs 2019 Feb;25(2):55

Editor, International Journal of Palliative Nursing.

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http://dx.doi.org/10.12968/ijpn.2019.25.2.55DOI Listing
February 2019

Hospice UK National Conference 2018.

Int J Palliat Nurs 2019 Feb;25(2):81-90

Patient Services Director, Heart of Kent Hospice.

Foreword Hospice UK's annual conference is the national hospice and palliative care charity's flagship event, bringing together everyone involved in leading hospice, palliative and end-of-life care for adults, children and young people. In 2018, the conference spanned two days and was held at the International Centre in Telford, Shropshire. Its theme was Transforming Palliative Care and it provided a unique forum for delegates to discuss current and forthcoming issues facing the hospice and palliative care community, and to discover new ways of thinking from outside of the sector. Read More

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http://dx.doi.org/10.12968/ijpn.2019.25.2.81DOI Listing
February 2019

Robot-assisted Simple Prostatectomy with Tunnel-Shaped Trigonization (RASP-TST) - A Novel Technique.

Int Braz J Urol 2019 Feb 10;45. Epub 2019 Feb 10.

Departamento de Urologia Hospital Alberto Cavalcanti, Belo Horizonte, MG, Brasil.

To describe a technical modifi cation for robotic-assisted simple prostatectomy (RASP) using three-steps reconstructive technique to achieve a 360 trigonization of the bladder mucosa. Through fi ve-trocars transperitoneal access, we perform a longitudinal incision of the bladder wall and prostate capsule. Our technique of RASP is very similar to the standard operative technique described during laparoscopic and robotic removal of adenoma, however, for reconstruction, we propose the Tunnel-Shaped Trigonization (TST). Read More

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http://dx.doi.org/10.1590/S1677-5538.IBJU.2018.0611DOI Listing
February 2019

Controlling Chirality across Length Scales using DNA.

Small 2019 Feb 20:e1805419. Epub 2019 Feb 20.

Physics Department, TU München, Am Coulombwall 4a/II - 85748 Garching b., München, Germany.

Nano-objects with chiral properties attract growing interest due to their relevance for a wide variety of technological applications. For example, chiral nano-objects may be used in characterization platforms that involve chiral molecular recognition of proteins or in the fabrication of nanomechanical devices such as screw-gears or nanoswimmers. Spatial ordering of emitters of circularly polarized light might greatly benefit from the utilization of chiral shapes. Read More

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http://dx.doi.org/10.1002/smll.201805419DOI Listing
February 2019

The role of maternal obesity in infant outcomes in polycystic ovary syndrome-A systematic review, meta-analysis, and meta-regression.

Obes Rev 2019 Feb 20. Epub 2019 Feb 20.

Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.

Polycystic ovary syndrome (PCOS) is associated with worsened pregnancy and infant outcomes, higher body mass index (BMI), and longitudinal weight gain. Despite most of the clinical features of PCOS being risk factors for worsened infant outcomes in the general population, their impact on infant outcomes in PCOS is unknown. We aimed to investigate the association of PCOS with infant outcomes considering maternal adiposity, other known risk factors, and potential confounders. Read More

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http://dx.doi.org/10.1111/obr.12832DOI Listing
February 2019

Effects of long-term diet supplementation with Gliricidia sepium foliage mixed with Enterolobium cyclocarpum pods on enteric methane, apparent digestibility, and rumen microbial population in crossbred heifers.

J Anim Sci 2019 Feb 19. Epub 2019 Feb 19.

Faculty of Veterinary Medicine and Animal Science, University of Yucatan, Carretera Merida-Xmatkuil, Itzimna, Merida, Yucatan, Mexico, C.P.

In the last decades, strategies have been evaluated to reduce rumen methane (CH4) production by supplementing tropical forages rich in secondary compounds; however, most of these beneficial effects need to be validated in terms of their persistence over time. The aim of this study was to assess CH4 emissions over time in heifers fed with and without Gliricidia sepium foliage (G) mixed with ground pods of Enterolobium cyclocarpum(E). Two groups of four crossbred (Bos taurus x Bos indicus) heifers (284 ±17 kg initial weight) were fed with two diets (0 and 15% of a mixture of the pods and foliage [E+G:0 and E+G:15, respectively] over 80 days, plus two weeks before the experiment, in which every animal was fed a legume and pod-free diet. Read More

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http://dx.doi.org/10.1093/jas/skz067DOI Listing
February 2019

Trend of hospitalizations and mortality from surgical causes in Brazil, 2008 to 2016.

Rev Col Bras Cir 2019 Feb 18;46(1):e1979. Epub 2019 Feb 18.

Universidade Estadual de Maringá, Programa de Pós-Graduação em Enfermagem, Maringá, PR, Brasil.

Objective: to evaluate the trend of hospitalazions for surgical procedures and surgical mortality in Brazil, from 2008 to 2016.

Methods: we conducted an ecological, time-series study. We obtained the data on surgical hospitalizations and mortality between 2008 and 2016 from the Department of Informatics of the Unified Health System (SUS). Read More

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http://dx.doi.org/10.1590/0100-6991e-20191979DOI Listing
February 2019

SERUM CYTOKINE OF IL-2, IL-10 AND IL-12 LEVELS IN PATIENTS WITH STOMACH ADENOCARCINOMA.

Arq Gastroenterol 2018 Oct-Dec;55(4):385-389

Mazandaran University of Medical Sciences, Faculty of Pharmacy, Department of Toxicology and Pharmacology, Pharmaceutical Research Center, Sari, Iran.

Background: Gastric adenocarcinoma is the fourth most common cause of cancer-associated death worldwide.

Objective: We evaluated the immunological status of patients with gastric cancer before surgery and circulating cytokines as potential diagnostic biomarkers for gastric cancer.

Methods: We included 90 healthy controls and 95 patients with distal Gastric adenocarcinoma in Mazandaran, Sari, Iran. Read More

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http://dx.doi.org/10.1590/S0004-2803.201800000-83DOI Listing

Membrane pore formation and ion selectivity of the Ebola virus delta peptide.

Phys Chem Chem Phys 2019 Feb 20. Epub 2019 Feb 20.

Department of Physics, Miami, FL 33199, USA and Biomolecular Sciences Institute Florida International University, Miami, FL 33199, USA.

The Ebola virus (EBOV) is a filamentous lipid-enveloped virus that causes severe hemorrhagic fever with a high fatality rate in humans. The EBOV encodes a glycoprotein that when cleaved, produces the delta peptide. Experimental evidence suggests that the delta peptide functions as a viroporin that enhances virus particle release through the host cell membrane. Read More

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http://dx.doi.org/10.1039/c8cp07323fDOI Listing
February 2019

Comorbidity and cognitive overlap between developmental dyslexia and congenital amusia.

Cogn Neuropsychol 2019 Feb 20:1-17. Epub 2019 Feb 20.

c Laboratoire de Sciences Cognitives et Psycholinguistique, Département d'Etudes Cognitives, Ecole Normale Supérieure , PSL Research University, EHESS, CNRS , Paris , France.

This study investigated whether there is a co-occurrence between developmental dyslexia and congenital amusia in adults. First, a database of online musical tests on 18,000 participants was analysed. Self-reported dyslexic participants performed significantly lower on melodic skills than matched controls, suggesting a possible link between reading and musical disorders. Read More

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https://www.tandfonline.com/doi/full/10.1080/02643294.2019.1
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http://dx.doi.org/10.1080/02643294.2019.1578205DOI Listing
February 2019
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Ginseng Extract Modified by Pectin Lyase Inhibits Retinal Vascular Injury and Blood-Retinal Barrier Breakage in a Rat Model of Diabetes.

J Med Food 2019 Feb 20. Epub 2019 Feb 20.

2 Clinical Research Division, Korea Institute of Oriental Medicine, Daejeon, South Korea.

GS-E3D is an enzymatically modified ginseng extract by pectin lyase. In this study, we evaluated the preventive effects of GS-E3D on blood-retinal barrier (BRB) leakage in a rat model of diabetes. To produce diabetes, rats were injected with streptozotocin. Read More

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http://dx.doi.org/10.1089/jmf.2018.4256DOI Listing
February 2019

Cost-Effectiveness Analysis of the MiniMed 670G Hybrid Closed-Loop System Versus Continuous Subcutaneous Insulin Infusion for Treatment of Type 1 Diabetes.

Diabetes Technol Ther 2019 Feb 20. Epub 2019 Feb 20.

4 HEVA HEOR, Lyon, France.

Background: Hybrid closed-loop (HCL) systems combine continuous glucose monitoring with continuous subcutaneous insulin infusion (CSII) to continuously self-adjust basal insulin delivery. Relative to CSII, HCL improves glycemic control and reduces the risk of hypoglycemia but has higher acquisition costs. The aim of this analysis was to assess the cost-effectiveness of the MiniMed™ 670G HCL system versus CSII in people with type 1 diabetes (T1D) in Sweden. Read More

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http://dx.doi.org/10.1089/dia.2018.0328DOI Listing
February 2019

From Single Molecules to Thin Film Electronics, Nanofibers, e-Textiles and Power Cables: Bridging Length Scales with Organic Semiconductors.

Adv Mater 2019 Feb 20:e1807286. Epub 2019 Feb 20.

Fibre and Polymer Technology, KTH Royal Institute of Technology, 100 44 Stockholm, Sweden.

Organic semiconductors are the centerpiece of several vibrant research fields from single-molecule to organic electronics, and they are finding increasing use in bioelectronics and even classical polymer technology. The versatile chemistry and broad range of electronic functionalities of conjugated materials enable the bridging of length scales 15 orders of magnitude apart, ranging from a single nanometer (10 m) to the size of continents (10 m). This work provides a taste of the diverse applications that can be realized with organic semiconductors. Read More

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http://dx.doi.org/10.1002/adma.201807286DOI Listing
February 2019

Addressing potential ethical issues regarding the supply of human-derived products or reagents in in vitro OECD Test Guidelines.

ALTEX 2019 Feb 19. Epub 2019 Feb 19.

Life Science Group Ltd, Wilden, Bedfordshire, UK.

The number and scope of Organisation for Economic Cooperation and Development (OECD) in vitro test guidelines (TGs) are increasing, in an effort to both improve human relevance and replace in vivo animal testing.  In vitro test methods being developed for TG use are increasing the use of human based reagents, in combination with, or replacing animal derived reagents, and demand for human reagents is likely to grow in the near future.  There are a range of issues associated with the ethical use of human reagents, particularly human serum, in the adaptation and development of in vitro TGs, especially to ensure that there is no human exploitation, legal requirements are adhered to, and that the origin of the reagent is assured. Read More

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http://dx.doi.org/10.14573/altex.1901281DOI Listing
February 2019

Flower-like FeS/BiS superstructures with improved near-infrared absorption for efficient chemo-photothermal therapy.

Dalton Trans 2019 Feb 20. Epub 2019 Feb 20.

State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, International Joint Laboratory for Advanced Fiber and Low-dimension Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, P.R. China. and College of Health Science and Environmental Engineering, Shenzhen Technology University, Shenzhen 518118, China.

Although various photothermal therapy (PTT) nanoagents have been developed in recent years, the rational design and easy synthesis of a PTT nanoplatform with improved near-infrared (NIR) absorption have remained challenging. Herein, via a facile one-pot solvothermal strategy, hydrophilic nanosheet-assembled flower-like Fe7S8/Bi2S3 superstructures were fabricated successfully. Such nanoflowers exhibit improved NIR absorption, which is 1. Read More

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http://dx.doi.org/10.1039/c8dt04280bDOI Listing
February 2019

Inhibitory effect of valproate sodium on pain behavior in diabetic mice involves suppression of spinal histone deacetylase 1 and inflammatory mediators.

Int Immunopharmacol 2019 Feb 18;70:16-27. Epub 2019 Feb 18.

Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Tabuk, Tabuk, Saudi Arabia; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt. Electronic address:

Anti-epileptic medications are included in the international guidelines for managing neuropathic pain. Valproate sodium (VPS) was recently described as "the forgotten analgesic" and has been reported to relief pain in various models of neuropathic pain. Some studies reported anti-inflammatory and histone deacetylase 1 (HDA1) inhibitory properties for sodium valproate. Read More

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http://dx.doi.org/10.1016/j.intimp.2019.01.050DOI Listing
February 2019

Associations of demographic and clinical factors with depression over 2.5-years in an international prospective cohort of people living with MS.

Mult Scler Relat Disord 2019 Feb 11;30:165-175. Epub 2019 Feb 11.

Neuroepidemiology Unit, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.

Background: Depression is highly prevalent among people with MS, and determinants thereof would be useful.

Objectives: We examined the relationship of demographic and clinical factors with positive depression-screen and change in depression over 2.5 years in people with MS. Read More

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http://dx.doi.org/10.1016/j.msard.2019.02.014DOI Listing
February 2019

Defining and listing very rare cancers of paediatric age: consensus of the Joint Action on Rare Cancers in cooperation with the European Cooperative Study Group for Pediatric Rare Tumors.

Eur J Cancer 2019 Feb 19;110:120-126. Epub 2019 Feb 19.

Department of Epidemiological Research and Molecular Medicine, Evaluative Epidemiology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Italy. Electronic address:

Although all tumours are rare in childhood, there are some particularly rare paediatric cancers which have not benefited from advances made by the international paediatric oncology network. To establish a shared definition and produce a list of these entities, the European Union Joint Action on Rare Cancers (JARC) promoted a consensus effort. The definition was based on the incidence rates estimated using the information network on rare cancers (RARECAREnet) database, pooling data from 94 population-based cancer registries and 27 countries. Read More

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http://dx.doi.org/10.1016/j.ejca.2018.12.031DOI Listing
February 2019