346 results match your criteria International journal of oral science[Journal]


Transient receptor potential Vanilloid 1-based gene therapy alleviates orthodontic pain in rats.

Int J Oral Sci 2019 Mar 11;11(1):11. Epub 2019 Mar 11.

State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China.

Orthodontic pain that is induced by tooth movement is an important sequela of orthodontic treatment and has a significant effect on patient quality of life. Studies have shown that the high expression of transient receptor potential vanilloid 1 (TRPV1) in trigeminal ganglions plays a vital role in the transmission and modulation of orofacial pain. However, little is known about the role of TRPV1 in orthodontic pain. Read More

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http://dx.doi.org/10.1038/s41368-019-0044-3DOI Listing

Oral bacteria colonize and compete with gut microbiota in gnotobiotic mice.

Int J Oral Sci 2019 Mar 5;11(1):10. Epub 2019 Mar 5.

State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, Sichuan University, Chengdu, China.

The oral microbiota is associated with oral diseases and digestive systemic diseases. Nevertheless, the causal relationship between them has not been completely elucidated, and colonisation of the gut by oral bacteria is not clear due to the limitations of existing research models. The aim of this study was to develop a human oral microbiota-associated (HOMA) mouse model and to investigate the ecological invasion into the gut. Read More

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http://dx.doi.org/10.1038/s41368-018-0043-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399334PMC
March 2019
2 Reads

Defining a critical period in calvarial development for Hedgehog pathway antagonist-induced frontal bone dysplasia in mice.

Int J Oral Sci 2019 Feb 20;11(1). Epub 2019 Feb 20.

Department of Oral and Maxillofacial Surgery, Union Hospital, Fujian Medical University, Fuzhou, Fujian, China.

The Hedgehog (Hh) signalling pathway is essential for cellular proliferation and differentiation during embryonic development. Gain and loss of function of Hh signalling are known to result in an array of craniofacial malformations. To determine the critical period for Hh pathway antagonist-induced frontal bone hypoplasia, we examined patterns of dysmorphology caused by Hh signalling inhibition. Read More

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http://dx.doi.org/10.1038/s41368-018-0040-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381108PMC
February 2019
2.029 Impact Factor

Chronic inflammation deteriorates structure and function of collagen fibril in rat temporomandibular joint disc.

Int J Oral Sci 2019 Feb 20;11(1). Epub 2019 Feb 20.

Department of Orthodontics, Peking University School and Hospital of Stomatology, 22# Zhongguancun South Avenue, Haidian District, Beijing, China.

Collagen is the building component of temporomandibular joint (TMJ) discs and is often affected by inflammation in temporomandibular disorders. The macromechanical properties of collagen are deteriorated by chronic inflammation. However, the mechanism by which inflammation influences disc function remains unknown. Read More

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http://dx.doi.org/10.1038/s41368-018-0036-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381164PMC
February 2019
1 Read

Caffeic acid phenethyl ester protects against oxidative stress and dampens inflammation via heme oxygenase 1.

Int J Oral Sci 2019 Feb 20;11(1). Epub 2019 Feb 20.

Department of Oral Biology, School of Dentistry, Medical University of Vienna, Sensengasse 2a, Vienna, Austria.

Periodontal disease is associated with chronic oxidative stress and inflammation. Caffeic acid phenethyl ester (CAPE), which is a potent inducer of heme oxygenase 1 (HO1), is a central active component of propolis, and the application of propolis improves periodontal status in diabetic patients. Here, primary murine macrophages were exposed to CAPE. Read More

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http://dx.doi.org/10.1038/s41368-018-0039-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381107PMC
February 2019
1 Read

Dental-craniofacial manifestation and treatment of rare diseases.

Int J Oral Sci 2019 Feb 20;11(1). Epub 2019 Feb 20.

State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.

Rare diseases are usually genetic, chronic and incurable disorders with a relatively low incidence. Developments in the diagnosis and management of rare diseases have been relatively slow due to a lack of sufficient profit motivation and market to attract research by companies. However, due to the attention of government and society as well as economic development, rare diseases have been gradually become an increasing concern. Read More

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http://dx.doi.org/10.1038/s41368-018-0041-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381182PMC
February 2019

Effect of the sonic hedgehog inhibitor GDC-0449 on an in vitro isogenic cellular model simulating odontogenic keratocysts.

Int J Oral Sci 2019 Jan 5;11(1). Epub 2019 Jan 5.

Department of Oral Pathology, Peking University School and Hospital of Stomatology, 22 South Zhongguancun Avenue, Haidian District, Beijing, China.

Odontogenic keratocysts (OKCs) are common cystic lesions of odontogenic epithelial origin that can occur sporadically or in association with naevoid basal cell carcinoma syndrome (NBCCS). OKCs are locally aggressive, cause marked destruction of the jaw bones and have a propensity to recur. PTCH1 mutations (at ∼80%) are frequently detected in the epithelia of both NBCCS-related and sporadic OKCs, suggesting that PTCH1 inactivation might constitutively activate sonic hedgehog (SHH) signalling and play a major role in disease pathogenesis. Read More

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http://dx.doi.org/10.1038/s41368-018-0034-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320367PMC
January 2019
3 Reads
2.029 Impact Factor

Enamel biomimetics-fiction or future of dentistry.

Int J Oral Sci 2019 Jan 5;11(1). Epub 2019 Jan 5.

Center for Craniofacial Research and Diagnosis, Texas A&M College of Dentistry, Dallas, TX, USA.

Tooth enamel is a complex mineralized tissue consisting of long and parallel apatite crystals configured into decussating enamel rods. In recent years, multiple approaches have been introduced to generate or regenerate this highly attractive biomaterial characterized by great mechanical strength paired with relative resilience and tissue compatibility. In the present review, we discuss five pathways toward enamel tissue engineering, (i) enamel synthesis using physico-chemical means, (ii) protein matrix-guided enamel crystal growth, (iii) enamel surface remineralization, (iv) cell-based enamel engineering, and (v) biological enamel regeneration based on de novo induction of tooth morphogenesis. Read More

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http://dx.doi.org/10.1038/s41368-018-0038-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320371PMC
January 2019
1 Read
2.029 Impact Factor

Long-term dexamethasone treatment diminishes store-operated Ca entry in salivary acinar cells.

Int J Oral Sci 2019 Jan 3;11(1). Epub 2019 Jan 3.

Division of Oral Reconstruction and Rehabilitation, Kyushu Dental University, Kitakyushu, Fukuoka, 803-8580, Japan.

Corticosteroids are used in the treatment of many diseases; however, they also induce various side effects. Dexamethasone is one of the most potent corticosteroids, and it has been reported to induce the side effect of impaired salivary gland function. This study aimed to evaluate the effects of dexamethasone on mouse submandibular gland function to gain insight into the mechanism of dexamethasone-induced salivary hypofunction. Read More

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http://dx.doi.org/10.1038/s41368-018-0031-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315037PMC
January 2019
1 Read

Author Correction: Single CD271 marker isolates mesenchymal stem cells from human dental pulp.

Int J Oral Sci 2019 Jan 2;11(1). Epub 2019 Jan 2.

Division of Oral Biology and Medicine, School of Dentistry, University of California at Los Angeles, Los Angeles, USA.

In the original version of this Article, Figure 1c was inadvertently assembled with a duplicate of Figure 1b. The correct image for Figure 1c, shown below, has been added in the HTML and PDF versions of the Article. This does not affect the conclusions of the study. Read More

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http://www.nature.com/articles/s41368-018-0042-x
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http://dx.doi.org/10.1038/s41368-018-0042-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315022PMC
January 2019
7 Reads

Salivary protease spectrum biomarkers of oral cancer.

Int J Oral Sci 2019 Jan 3;11(1). Epub 2019 Jan 3.

State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.

Proteases are important molecules that are involved in many physiological and pathological processes of the human body, such as growth, apoptosis and metastasis cancer cells. They are potential targets in cancer diagnosis and biotherapy. In this study, we analyzed the salivary protease spectrum of patients with oral squamous cell carcinoma (OSCC), oral benign masses and chronic periodontitis, as well as that of health, using human protease array kits, enzyme-linked immunosorbent assay, western blot and immunofluorescence. Read More

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http://dx.doi.org/10.1038/s41368-018-0032-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315043PMC
January 2019
2 Reads
2.029 Impact Factor

Increased virulence of the oral microbiome in oral squamous cell carcinoma revealed by metatranscriptome analyses.

Int J Oral Sci 2018 11 12;10(4):32. Epub 2018 Nov 12.

Department of Oral Biology, College of Dentistry, University of Florida, 1395 Center Drive, Gainesville, FL, 32610-0424, USA.

Oral squamous cell carcinoma (OSCC) is the most prevalent and most commonly studied oral cancer. However, there is a void regarding the role that the oral microbiome may play in OSCC. Although the relationship between microbial community composition and OSCC has been thoroughly investigated, microbial profiles of the human microbiome in cancer are understudied. Read More

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http://dx.doi.org/10.1038/s41368-018-0037-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6232154PMC
November 2018
4 Reads

The functional significance of dentin sialoprotein-phosphophoryn and dentin sialoprotein.

Authors:
Helena Ritchie

Int J Oral Sci 2018 11 5;10(4):31. Epub 2018 Nov 5.

Department of Cariology, Restorative Sciences and Endodontics, University of Michigan School of Dentistry, Ann Arbor, USA.

Phosphophoryn (PP) and dentin sialoprotein (DSP) are the most dominant non-collagenous proteins in dentin. PP is an extremely acidic protein that can function as a mineral nucleator for dentin mineralization. DSP was first identified in 1981, yet its functional significance is still controversial. Read More

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http://www.nature.com/articles/s41368-018-0035-9
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http://dx.doi.org/10.1038/s41368-018-0035-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215839PMC
November 2018
13 Reads

ERK phosphorylation functions in invadopodia formation in tongue cancer cells in a novel silicate fibre-based 3D cell culture system.

Int J Oral Sci 2018 10 22;10(4):30. Epub 2018 Oct 22.

Department of Pathology, Division of Molecular Diagnostic Pathology, Shiga University of Medical Science, Ōtsu, Shiga, Japan.

To screen for additional treatment targets against tongue cancer, we evaluated the contributions of extracellular signal-related kinase (ERK), AKT and ezrin in cancer development. Immunohistochemical staining showed that ERK and ezrin expressions were significantly higher in invasive squamous cell carcinoma than in carcinoma in situ. To investigate the roles of ERK and ezrin in cancer development, we used the non-woven silica fibre sheet Cellbed with a structure resembling the loose connective tissue morphology in a novel 3D culture system. Read More

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http://www.nature.com/articles/s41368-018-0033-y
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http://dx.doi.org/10.1038/s41368-018-0033-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196225PMC
October 2018
11 Reads

TGF-β2 downregulates osteogenesis under inflammatory conditions in dental follicle stem cells.

Int J Oral Sci 2018 10 9;10(3):29. Epub 2018 Oct 9.

Biotooth Engineering Lab, Department of Oral and Maxillofacial Surgery and Craniomaxillofacial Life Science, Dental Research Institute, School of Dentistry, Seoul National University, Seoul, Korea.

Bone formation is important for the reconstruction of bone-related structures in areas that have been damaged by inflammation. Inflammatory conditions such as those that occur in patients with rheumatoid arthritis, cystic fibrosis, and periodontitis have been shown to inhibit osteoblastic differentiation. This study focussed on dental follicle stem cells (DFSCs), which are found in developing tooth germ and participate in the reconstruction of alveolar bone and periodontal tissue in periodontal disease. Read More

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http://dx.doi.org/10.1038/s41368-018-0028-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175959PMC
October 2018
2 Reads

Whole exome sequencing identifies an AMBN missense mutation causing severe autosomal-dominant amelogenesis imperfecta and dentin disorders.

Int J Oral Sci 2018 09 3;10(3):26. Epub 2018 Sep 3.

Department of Medical Genetics, School of Basic Medicine Sciences, Southern Medical University, Guangzhou, Guangdong, China.

Tooth development is a complex process that involves precise and time-dependent orchestration of multiple genetic, molecular, and cellular interactions. Ameloblastin (AMBN, also named "amelin" or "sheathlin") is the second most abundant enamel matrix protein known to have a key role in amelogenesis. Amelogenesis imperfecta (AI [MIM: 104500]) refers to a genetically and phenotypically heterogeneous group of conditions characterized by inherited developmental enamel defects. Read More

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http://dx.doi.org/10.1038/s41368-018-0027-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6119682PMC
September 2018
3 Reads

Selective serotonin re-uptake inhibitor sertraline inhibits bone healing in a calvarial defect model.

Int J Oral Sci 2018 09 3;10(3):25. Epub 2018 Sep 3.

Oral Health Sciences, Medical University of South Carolina, Charleston, SC, USA.

Bone wound healing is a highly dynamic and precisely controlled process through which damaged bone undergoes repair and complete regeneration. External factors can alter this process, leading to delayed or failed bone wound healing. The findings of recent studies suggest that the use of selective serotonin reuptake inhibitors (SSRIs) can reduce bone mass, precipitate osteoporotic fractures and increase the rate of dental implant failure. Read More

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http://dx.doi.org/10.1038/s41368-018-0026-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6119683PMC
September 2018
3 Reads

Transcriptional activation of glucose transporter 1 in orthodontic tooth movement-associated mechanical response.

Int J Oral Sci 2018 08 15;10(3):27. Epub 2018 Aug 15.

Department of Orthodontics, Peking University School and Hospital of Stomatology, Beijing, China.

The interplay between mechanoresponses and a broad range of fundamental biological processes, such as cell cycle progression, growth and differentiation, has been extensively investigated. However, metabolic regulation in mechanobiology remains largely unexplored. Here, we identified glucose transporter 1 (GLUT1)-the primary glucose transporter in various cells-as a novel mechanosensitive gene in orthodontic tooth movement (OTM). Read More

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http://www.nature.com/articles/s41368-018-0029-7
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http://dx.doi.org/10.1038/s41368-018-0029-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6093892PMC
August 2018
19 Reads

Meeting report: a close look at oral biofilms and microbiomes.

Int J Oral Sci 2018 08 15;10(3):28. Epub 2018 Aug 15.

State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of Cariology and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China.

The "Biofilms, Microbiomes and Oral Diseases: Challenges and Future Perspectives" symposium jointly organized by Penn Dental Medicine and West China School of Stomatology was held on 30 September 2017 at Penn Wharton China Center (PWCC) in Beijing, China. The topics included the pathogenicity of oral biofilms, novel strategies for the control of biofilm-related diseases, oral microbiome and single-cell approaches, and the link between oral diseases and overall health. Researchers from a number of disciplines, representing institutions from China and Penn Dental Medicine, gathered to discuss advances in our understanding of biofilms, as well as future directions for the control of biofilm-related oral and systemic diseases. Read More

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http://www.nature.com/articles/s41368-018-0030-1
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http://dx.doi.org/10.1038/s41368-018-0030-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6093876PMC
August 2018
26 Reads

MicroRNAs and immunity in periodontal health and disease.

Int J Oral Sci 2018 08 6;10(3):24. Epub 2018 Aug 6.

Department of Periodontics, Texas A&M College of Dentistry, Chicago, IL, USA.

MicroRNAs (miRNAs) are critical regulators of the host immune and inflammatory response against bacterial pathogens. In the present review, we discuss target genes, target gene functions, the potential regulatory role of miRNAs in periodontal tissues, and the potential role of miRNAs as biomarkers and therapeutics. In periodontal disease, miRNAs exert control over all aspects of innate and adaptive immunity, including the functions of neutrophils, macrophages, dendritic cells and T and B cells. Read More

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http://dx.doi.org/10.1038/s41368-018-0025-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6080405PMC
August 2018
14 Reads

Streptococcus mutans activates the AIM2, NLRP3 and NLRC4 inflammasomes in human THP-1 macrophages.

Int J Oral Sci 2018 08 6;10(3):23. Epub 2018 Aug 6.

Department of Oral Microbiology, School of Dentistry, Pusan National University, Yangsan, 50162, Korea.

Streptococcus mutans (S. mutans), a major aetiologic agent of dental caries, is involved in systemic diseases, such as bacterial endocarditis, if it enters the bloodstream through temporary bacteraemia. Interleukin (IL)-1β, a proinflammatory cytokine, is related to the host defences against pathogens, and its synthesis, maturation, and secretion are tightly regulated by the activation of the inflammasome, an inflammatory signalling complex. Read More

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http://dx.doi.org/10.1038/s41368-018-0024-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6080406PMC
August 2018
2 Reads

Effect of low-level laser therapy on tooth-related pain and somatosensory function evoked by orthodontic treatment.

Int J Oral Sci 2018 07 2;10(3):22. Epub 2018 Jul 2.

Center for Sensory-Motor Interaction (SMI), Department of Health Science and Technology, Aalborg University, Aalborg, Denmark.

Low-level laser therapy (LLLT) may have an effect on the pain associated with orthodontic treatment. The aim of this study was to evaluate the effect of LLLT on pain and somatosensory sensitization induced by orthodontic treatment. Forty individuals (12-33 years old; mean ± standard deviations: 20. Read More

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http://dx.doi.org/10.1038/s41368-018-0023-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6028457PMC
July 2018
11 Reads

Epithelial cell adhesion efficacy of a novel peptide identified by panning on a smooth titanium surface.

Int J Oral Sci 2018 07 2;10(3):21. Epub 2018 Jul 2.

Harvard School of Dental Medicine, Boston, MA, USA.

Epithelial attachment via the basal lamina on the tooth surface provides an important structural defence mechanism against bacterial invasion in combating periodontal disease. However, when considering dental implants, strong epithelial attachment does not exist throughout the titanium-soft tissue interface, making soft tissues more susceptible to peri-implant disease. This study introduced a novel synthetic peptide (A10) to enhance epithelial attachment. Read More

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http://dx.doi.org/10.1038/s41368-018-0022-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6026594PMC
July 2018
5 Reads

Effects of water-aging for 6 months on the durability of a novel antimicrobial and protein-repellent dental bonding agent.

Int J Oral Sci 2018 06 21;10(2):18. Epub 2018 Jun 21.

Biomatexrials & Tissue Engineering Division, Department of Endodontics, Periodontics and Prosthodontics, University of Maryland Dental School, Baltimore, MD, USA.

Biofilms at the tooth-restoration bonded interface can produce acids and cause recurrent caries. Recurrent caries is a primary reason for restoration failures. The objectives of this study were to synthesize a novel bioactive dental bonding agent containing dimethylaminohexadecyl methacrylate (DMAHDM) and 2-methacryloyloxyethyl phosphorylcholine (MPC) to inhibit biofilm formation at the tooth-restoration margin and to investigate the effects of water-aging for 6 months on the dentin bond strength and protein-repellent and antibacterial durability. Read More

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http://dx.doi.org/10.1038/s41368-018-0019-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6010414PMC
June 2018
20 Reads

Local icariin application enhanced periodontal tissue regeneration and relieved local inflammation in a minipig model of periodontitis.

Int J Oral Sci 2018 06 12;10(2):19. Epub 2018 Jun 12.

Department of Periodontology, Capital Medical University School of Stomatology, Beijing, China.

Periodontitis is an inflammatory autoimmune disease. Treatment should alleviate inflammation, regulate the immune reaction and promote periodontal tissue regeneration. Icariin is the main active ingredient of Epimedii Folium, and it is a promising compound for the enhancement of mesenchymal stem cell function, promotion of bone formation, inhibition of bone resorption, alleviation of inflammation and regulation of immunity. Read More

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http://dx.doi.org/10.1038/s41368-018-0020-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5997630PMC
June 2018
33 Reads

Bone-conditioned medium contributes to initiation and progression of osteogenesis by exhibiting synergistic TGF-β1/BMP-2 activity.

Int J Oral Sci 2018 06 12;10(2):20. Epub 2018 Jun 12.

Department of Oral Surgery and Stomatology, School of Dental Medicine, University of Bern, Bern, Switzerland.

Guided bone regeneration (GBR) often utilizes a combination of autologous bone grafts, deproteinized bovine bone mineral (DBBM), and collagen membranes. DBBM and collagen membranes pre-coated with bone-conditioned medium (BCM) extracted from locally harvested autologous bone chips have shown great regenerative potential in GBR. However, the underlying molecular mechanism remains largely unknown. Read More

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http://dx.doi.org/10.1038/s41368-018-0021-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5997631PMC
June 2018
6 Reads

Differentiation of periapical granulomas and cysts by using dental MRI: a pilot study.

Int J Oral Sci 2018 05 17;10(2):17. Epub 2018 May 17.

Department of Neuroradiology, Heidelberg University Hospital, Im Neuenheimer Feld 400, Heidelberg, Germany.

The purpose of this pilot study was to evaluate whether periapical granulomas can be differentiated from periapical cysts in vivo by using dental magnetic resonance imaging (MRI). Prior to apicoectomy, 11 patients with radiographically confirmed periapical lesions underwent dental MRI, including fat-saturated T2-weighted (T2wFS) images, non-contrast-enhanced T1-weighted images with and without fat saturation (T1w/T1wFS), and contrast-enhanced fat-saturated T1-weighted (T1wFS+C) images. Two independent observers performed structured image analysis of MRI datasets twice. Read More

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http://dx.doi.org/10.1038/s41368-018-0017-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5966810PMC
May 2018
4 Reads

The Oral Microbiome Bank of China.

Int J Oral Sci 2018 05 3;10(2):16. Epub 2018 May 3.

State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.

The human microbiome project (HMP) promoted further understanding of human oral microbes. However, research on the human oral microbiota has not made as much progress as research on the gut microbiota. Currently, the causal relationship between the oral microbiota and oral diseases remains unclear, and little is known about the link between the oral microbiota and human systemic diseases. Read More

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http://dx.doi.org/10.1038/s41368-018-0018-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5966808PMC
May 2018
4 Reads

Recombinant amelogenin regulates the bioactivity of mouse cementoblasts in vitro.

Int J Oral Sci 2018 05 9;10(2):15. Epub 2018 May 9.

Department of Orthodontics, Oral Biology Laboratory, Faculty of Dentistry, University of Bonn, Bonn, Germany.

Amelogenin (AMG) is a cell adhesion molecule that has an important role in the mineralization of enamel and regulates events during dental development and root formation. The purpose of the present study was to investigate the effects of recombinant human AMG (rhAMG) on mineralized tissue-associated genes in cementoblasts. Immortalized mouse cementoblasts (OCCM-30) were treated with different concentrations (0. Read More

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http://dx.doi.org/10.1038/s41368-018-0010-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5966809PMC
May 2018
2 Reads

Autonomic reinnervation and functional regeneration in autologous transplanted submandibular glands in patients with severe keratoconjunctivitis sicca.

Int J Oral Sci 2018 04 25;10(2):14. Epub 2018 Apr 25.

Center for Salivary Gland Diseases and Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, Beijing, China.

Autologous submandibular gland (SMG) transplantation has been proved to ameliorate the discomforts in patients with severe keratoconjunctivitis sicca. The transplanted glands underwent a hypofunctional period and then restored secretion spontaneously. This study aims to investigate whether autonomic nerves reinnervate the grafts and contribute to the functional recovery, and further determine the origin of these nerves. Read More

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http://dx.doi.org/10.1038/s41368-018-0014-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5944256PMC
April 2018
8 Reads

Activation of β-catenin signaling in aggrecan-expressing cells in temporomandibular joint causes osteoarthritis-like defects.

Int J Oral Sci 2018 04 23;10(2):13. Epub 2018 Apr 23.

Department of Orthopaedic Surgery, Rush University Medical Center, Chicago, USA.

β-Catenin plays a critical role in cartilage formation and development. To further understand the role of β-catenin in osteoarthritis (OA) development in temporomandibular joint (TMJ), we have generated β-catenin conditional activation mice (β-cat(ex3) ) by breeding Agc1-CreER mice with β-catenin mice. Results of histologic analysis showed the progressive TMJ defects in 3- and 6-month-old β-cat(ex3) mice (tamoxifen induction was performed at 2 weeks of age), including decreased chondrocyte numbers in the superficial layer associated with less Alcian blue staining, increased numbers of hypertrophic chondrocytes in deep layers, and rough articular surface. Read More

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http://dx.doi.org/10.1038/s41368-018-0016-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5966811PMC
April 2018
9 Reads

Activation of hypoxia-inducible factor 1 attenuates periapical inflammation and bone loss.

Int J Oral Sci 2018 04 13;10(2):12. Epub 2018 Apr 13.

Department of Cariology, Restorative Sciences & Endodontics, University of Michigan School of Dentistry, Ann Arbor, MI, USA.

Hypoxia (low oxygen level) is an important feature during infections and affects the host defence mechanisms. The host has evolved specific responses to address hypoxia, which are strongly dependent on the activation of hypoxia-inducible factor 1 (HIF-1). Hypoxia interferes degradation of HIF-1 alpha subunit (HIF-1α), leading to stabilisation of HIF-1α, heterodimerization with HIF-1 beta subunit (HIF-1β) and subsequent activation of HIF-1 pathway. Read More

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http://dx.doi.org/10.1038/s41368-018-0015-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5966812PMC
April 2018
47 Reads

The importance of a potential phosphorylation site in enamelin on enamel formation.

Int J Oral Sci 2017 11 29;9(11):e4. Epub 2017 Nov 29.

Department of Biomedical Sciences and Center for Craniofacial Research and Diagnosis, Texas A&M University College of Dentistry, Dallas, USA.

Enamelin (ENAM) has three putative phosphoserines (pSers) phosphorylated by a Golgi-associated secretory pathway kinase (FAM20C) based on their distinctive Ser-x-Glu (S-x-E) motifs. Fam20C-knockout mice show severe enamel defects similar to those in the Enam-knockout mice, implying an important role of the pSers in ENAM. To determine the role of pSer in ENAM, we characterized ENAM mice, in which Ser cannot be phosphorylated by FAM20C due to an E>G mutation in the S-x-E motif. Read More

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http://dx.doi.org/10.1038/ijos.2017.41DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5775333PMC
November 2017
5 Reads

Accelerated and enhanced osteointegration of MAO-treated implants: histological and histomorphometric evaluation in a rabbit model.

Int J Oral Sci 2018 03 22;10(2):11. Epub 2018 Mar 22.

School of Stomatology, Qingdao University, Qingdao, China.

Microarc oxidation (MAO) has become a promising technique for the surface modification of implants. Therefore, the aims of this study were to further quantitatively and qualitatively evaluate the osteointegration abilities of MAO-treated and smooth surface (SF) implants in vivo and to investigate the areas in which the superiority of MAO-treated implants are displayed. In a rabbit model, a comprehensive histomorphological, osteogenic, mineralizational, and integrative assessment was performed using light microscopy, fluorescence microscopy, confocal laser scanning microscopy, and radiographic analyses. Read More

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http://dx.doi.org/10.1038/s41368-018-0008-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5944253PMC
March 2018
3 Reads

Orthodontic tooth separation activates the hypothalamic area in the human brain.

Int J Oral Sci 2018 03 15;10(2). Epub 2018 Mar 15.

Department of Oral and Maxillofacial Radiology, Aichi-Gakuin University School of Dentistry, Nagoya, Japan.

Objectives: An animal experiment clarified that insertion of an orthodontic apparatus activated the trigeminal neurons of the medulla oblongata. Orthodontic tooth movement is known to be associated with the sympathetic nervous system and controlled by the nucleus of the hypothalamus. However, the transmission of both has not been demonstrated in humans. Read More

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http://dx.doi.org/10.1038/s41368-017-0001-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5944252PMC
March 2018
9 Reads

In-vivo optical imaging in head and neck oncology: basic principles, clinical applications and future directions.

Int J Oral Sci 2018 03 18;10(2):10. Epub 2018 Mar 18.

Department of Otolaryngology and Radiology, Stanford University, 94305, Stanford, CA, USA.

Head and neck cancers become a severe threat to human's health nowadays and represent the sixth most common cancer worldwide. Surgery remains the first-line choice for head and neck cancer patients. Limited resectable tissue mass and complicated anatomy structures in the head and neck region put the surgeons in a dilemma between the extensive resection and a better quality of life for the patients. Read More

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http://dx.doi.org/10.1038/s41368-018-0011-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5944254PMC
March 2018
5 Reads

ERG3 and ERG11 genes are critical for the pathogenesis of Candida albicans during the oral mucosal infection.

Int J Oral Sci 2018 03 16;10(2). Epub 2018 Mar 16.

State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.

The hyphal development of Candida albicans (C. albicans) has been considered as an essential virulent factor for host cell damage. However, the missing link between hyphae and virulence of C. Read More

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http://dx.doi.org/10.1038/s41368-018-0013-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5944255PMC
March 2018
6 Reads

Common dental diseases in children and malocclusion.

Int J Oral Sci 2018 03 13;10(1). Epub 2018 Mar 13.

State Key Laboratory of Oral Diseases& National Clinical Research Center for Oral Diseases & Department of Pediatric Dentistry, West China School of Stomatology, Sichuan University, Chengdu 610041, China.

Malocclusion is a worldwide dental problem that influences the affected individuals to varying degrees. Many factors contribute to the anomaly in dentition, including hereditary and environmental aspects. Dental caries, pulpal and periapical lesions, dental trauma, abnormality of development, and oral habits are most common dental diseases in children that strongly relate to malocclusion. Read More

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http://dx.doi.org/10.1038/s41368-018-0012-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5944594PMC
March 2018
15 Reads

Effect of high-frequency loading and parathyroid hormone administration on peri-implant bone healing and osseointegration.

Int J Oral Sci 2018 03 13;10(1). Epub 2018 Mar 13.

Division of Advanced Prosthetic Dentistry, Tohoku University Graduate School of Dentistry, Sendai, Japan.

The objective of this study is to examine the effect of low-magnitude, high-frequency (LMHF) loading, and anti-osteoporosis medications such as parathyroid hormone (PTH) and bisphosphonates on peri-implant bone healing in an osteoporosis model, and to assess their combined effects on these processes. Thirteen-week-old ovariectomized rats (n = 44) were divided into three groups: PTH, alendronate, and saline. After 3 weeks of drug administration, titanium implants were inserted into the tibiae. Read More

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http://www.nature.com/articles/s41368-018-0009-y
Publisher Site
http://dx.doi.org/10.1038/s41368-018-0009-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5944597PMC
March 2018
4 Reads

Influence of glass-based dental ceramic type and thickness with identical shade on the light transmittance and the degree of conversion of resin cement.

Int J Oral Sci 2018 03 2;10(1). Epub 2018 Mar 2.

Department of Conservative Dentistry and Dental Research Institute, School of Dentistry, Seoul National University, Seoul, Korea.

The purpose of this study was to assess the influence of the types and thicknesses of glass ceramic plates on light transmittance and compare the degrees of conversion (DC) of resin cement under the ceramic materials. Three ceramic plates with thicknesses of 0.5, 1. Read More

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http://www.nature.com/articles/s41368-017-0005-7
Publisher Site
http://dx.doi.org/10.1038/s41368-017-0005-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5944596PMC
March 2018
15 Reads

Ectomesenchymal chondromyxoid tumor: a comprehensive updated review of the literature and case report.

Int J Oral Sci 2018 02 28;10(1). Epub 2018 Feb 28.

IMAH, Institute of Morphological Analytics and Human Genetics, Grabenstraße 23, 8010, Graz, Austria.

Prompted by a unique case of an ectomesenchymal chondromyxoid tumor (ECT) of the palate in a 54-year-old female, we reviewed the English and German literature on this entity until the end of 2016 using PubMed. The search produced 74 lingual cases with a nearly equal sex distribution and a mean age of 39.3 years, and two extra-lingual cases sharing histological and immunohistological features including nodular growth, round, fusiform or spindle-shaped cellular architecture, and chondromyxoid stroma. Read More

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http://dx.doi.org/10.1038/s41368-017-0003-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5944469PMC
February 2018
12 Reads

RANKL deletion in periodontal ligament and bone lining cells blocks orthodontic tooth movement.

Int J Oral Sci 2018 02 26;10(1). Epub 2018 Feb 26.

Department of Periodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA.

The bone remodeling process in response to orthodontic forces requires the activity of osteoclasts to allow teeth to move in the direction of the force applied. Receptor activator of nuclear factor-κB ligand (RANKL) is essential for this process although its cellular source in response to orthodontic forces has not been determined. Orthodontic tooth movement is considered to be an aseptic inflammatory process that is stimulated by leukocytes including T and B lymphocytes which are presumed to stimulate bone resorption. Read More

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http://dx.doi.org/10.1038/s41368-017-0004-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5944595PMC
February 2018
12 Reads

Osteocyte morphology and orientation in relation to strain in the jaw bone.

Int J Oral Sci 2018 02 26;10(1). Epub 2018 Feb 26.

Department of Oral Cell Biology, Academic Centre for Dentistry Amsterdam (ACTA), Amsterdam Movement Sciences, University of Amsterdam and Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.

Bone mass is important for dental implant success and is regulated by mechanoresponsive osteocytes. We aimed to investigate the relationship between the levels and orientation of tensile strain and morphology and orientation of osteocytes at different dental implant positions in the maxillary bone. Bone biopsies were retrieved from eight patients who underwent maxillary sinus-floor elevation with β-tricalcium phosphate prior to implant placement. Read More

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http://dx.doi.org/10.1038/s41368-017-0007-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5944599PMC
February 2018
5 Reads

Oral health in China: from vision to action.

Int J Oral Sci 2018 01 17;10(1). Epub 2018 Jan 17.

National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, China.

Chinese president Xi Jinping made clear at the National Health and Wellness Conference that health is the prerequisite for people's all-around development and a precondition for the sustainable development of China. Oral health is an indispensable component of overall health in humans. However, the long neglect of oral health in overall health agendas has made oral diseases an increasing concern. Read More

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http://dx.doi.org/10.1038/s41368-017-0006-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5944598PMC
January 2018
9 Reads

Analysis of differential expression of tight junction proteins in cultured oral epithelial cells altered by Porphyromonas gingivalis, Porphyromonas gingivalis lipopolysaccharide, and extracellular adenosine triphosphate.

Int J Oral Sci 2018 01 10;10(1):e8. Epub 2018 Jan 10.

Institute of Dental Research, Centre for Oral Health, Westmead Hospital, Westmead, Australia.

Tight junctions (TJs) are the most apical intercellular junctions of epithelial cells formed by occludin, claudins, junctional adhesion molecules (JAMs), and zonula occludens (ZO). Tight junction proteins can sense the presence of bacteria and regulate the transcription of target genes that encode effectors and regulators of the immune response. The aim of this study was to determine the impact of TJ proteins in response to Porphyromonas gingivalis (P. Read More

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http://dx.doi.org/10.1038/ijos.2017.51DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5795020PMC
January 2018
6 Reads

Interleukin-1β induces human cementoblasts to support osteoclastogenesis.

Int J Oral Sci 2017 12 13;9(12):e5. Epub 2017 Dec 13.

Research Unit on Oral Microbiology and Immunology, Microbiology Department, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand.

Injury of the periodontium followed by inflammatory response often leads to root resorption. Resorption is accomplished by osteoclasts and their generation may depend on an interaction with the cells in direct contact with the root, the cementoblasts. Our study aimed to investigate the role of human cementoblasts in the formation of osteoclasts and the effect of interleukin (IL)-1β hereupon. Read More

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http://dx.doi.org/10.1038/ijos.2017.45DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5729550PMC
December 2017
5 Reads

Meeting report: a hard look at the state of enamel research.

Int J Oral Sci 2017 11 22;9(11):e3. Epub 2017 Nov 22.

Biologic and Materials Sciences and Division of Prosthodontics, University of Michigan, Ann Arbor, USA.

The Encouraging Novel Amelogenesis Models and Ex vivo cell Lines (ENAMEL) Development workshop was held on 23 June 2017 at the Bethesda headquarters of the National Institute of Dental and Craniofacial Research (NIDCR). Discussion topics included model organisms, stem cells/cell lines, and tissues/3D cell culture/organoids. Scientists from a number of disciplines, representing institutions from across the United States, gathered to discuss advances in our understanding of enamel, as well as future directions for the field. Read More

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http://dx.doi.org/10.1038/ijos.2017.40DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5775332PMC
November 2017
19 Reads

Salivary proteins and microbiota as biomarkers for early childhood caries risk assessment.

Int J Oral Sci 2017 11 10;9(11):e1. Epub 2017 Nov 10.

State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of Pediatric Dentistry, West China Hospital of Stomatology, Sichuan University, Chengdu, China.

Early childhood caries (ECC) is a term used to describe dental caries in children aged 6 years or younger. Oral streptococci, such as Streptococcus mutans and Streptococcus sorbrinus, are considered to be the main etiological agents of tooth decay in children. Other bacteria, such as Prevotella spp. Read More

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http://dx.doi.org/10.1038/ijos.2017.35DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5775330PMC
November 2017
13 Reads

Detection accuracy for epithelial dysplasia using an objective autofluorescence visualization method based on the luminance ratio.

Int J Oral Sci 2017 11 10;9(11):e2. Epub 2017 Nov 10.

Department of Oral and Maxillofacial Surgery, School of Dental Medicine, Tsurumi University, Yokohama, Japan.

The autofluorescence visualization method (AVM) uses blue excitation light to assist in the diagnosis of epithelial dysplasia. It detects epithelial dysplasia as a black area, which is known as fluorescence visualization loss (FVL). In this study, we evaluated the detection accuracy for epithelial dysplasia of the tongue using the objective AVM and assessed its possible clinical utility. Read More

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http://dx.doi.org/10.1038/ijos.2017.37DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5775331PMC
November 2017
22 Reads

Doxycycline induces bone repair and changes in Wnt signalling.

Int J Oral Sci 2017 09;9(3):158-166

Faculty of Medicine, Federal University of Ceará, Fortaleza, Brazil.

Doxycycline (DOX) exhibits anti-inflammatory and MMP inhibitory properties. The objectives of this study were to evaluate the effects of DOX on alveolar bone repair. Controls (CTL) and DOX-treated (10 and 25 mg·kg) molars were extracted, and rats were killed 7 or 14 days later. Read More

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http://dx.doi.org/10.1038/ijos.2017.28DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5709545PMC
September 2017
24 Reads