393 results match your criteria International journal of nephrology[Journal]


Kidney Injury Molecule 1 (KIM-1) as an Early Predictor for Acute Kidney Injury in Post-Cardiopulmonary Bypass (CPB) in Open Heart Surgery Patients.

Int J Nephrol 2019 12;2019:6265307. Epub 2019 Mar 12.

Mansoura Nephrology and Dialysis Unit, Internal Medicine Department, Mansoura University, Egypt.

Introduction: Postoperative acute kidney injury is associated with a higher mortality, a more complicated hospital course with longer hospital stay. Urinary kidney injury molecule 1 may play an important role as an early predictor of acute kidney injury post-cardiopulmonary in open heart surgery.

Methods: We evaluated 45 patients who underwent open heart surgery from January 2016 to June 2016. Read More

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http://dx.doi.org/10.1155/2019/6265307DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434264PMC
March 2019
1 Read

Reduced Kidney Function in Tenofovir Disoproxil Fumarate Based Regimen and Associated Factors: A Hospital Based Prospective Observational Study in Ethiopian Patients.

Int J Nephrol 2019 3;2019:9172607. Epub 2019 Feb 3.

Department of Internal Medicine, Addis Ababa University, Addis Ababa, Ethiopia.

Purpose: Tenofovir disoproxil fumarate (TDF), a drug broadly used in combination antiretroviral therapy, is associated with renal dysfunction but the prevalence varied from country to country and it is not known in Ethiopia. The objectives of this study were to assess the prevalence of renal dysfunction and risk factors associated with it and the mean change in estimated glomerular filtration rate in human immunodeficiency virus infected patients receiving TDF based antiretroviral regimen at Tikur Anbessa Specialized Hospital.

Method: It was a hospital based prospective cohort study. Read More

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http://dx.doi.org/10.1155/2019/9172607DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377960PMC
February 2019
5 Reads

Renal Recovery following Liposomal Amphotericin B-Induced Nephrotoxicity.

Int J Nephrol 2019 28;2019:8629891. Epub 2019 Jan 28.

Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, USA.

Background: Acute kidney injury (AKI) is a common complication of treatment with liposomal amphotericin B (LAmB). The trajectory of renal recovery after LAmB-associated AKI has not been well described, nor has effect of LAmB dose on recovery of renal function been explored.

Objective: Characterize the pattern of renal recovery after incident AKI during LAmB and determine potential influencing factors. Read More

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http://dx.doi.org/10.1155/2019/8629891DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369474PMC
January 2019
1 Read

Functional and Respiratory Capacity of Patients with Chronic Kidney Disease Undergoing Cycle Ergometer Training during Hemodialysis Sessions: A Randomized Clinical Trial.

Int J Nephrol 2019 21;2019:7857824. Epub 2019 Jan 21.

PT, PhD. Associate Professor in Santa Casa de Sao Paulo School of Medical Sciences, São Paulo, SP, Brazil.

Purpose: Exercise is recommended for patients undergoing hemodialysis, to reduce the decrease in functional capacity secondary to the progression of chronic kidney disease. A cycle ergometer can be easily added to an exercise routine during hemodialysis sessions. The purpose of this article was to assess the results of a training protocol with the cycle ergometer during hemodialysis sessions on the respiratory function and functional capacity of patients with chronic kidney disease on hemodialysis. Read More

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http://dx.doi.org/10.1155/2019/7857824DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360580PMC
January 2019

Management Practice, and Adherence and Its Contributing Factors among Patients with Chronic Kidney Disease at Tikur Anbessa Specialized Hospital: A Hospital Based Cross-Sectional Study.

Int J Nephrol 2018 29;2018:2903139. Epub 2018 Jul 29.

Department of Pharmacology and Clinical Pharmacy, School of Pharmacy, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.

The objective of this study was to assess the management practice, medication adherence, and factors affecting medication adherence in CKD patients at Tikur Anbessa Specialized Hospital (TASH). . A cross-sectional study was conducted at the nephrology clinic of TASH. Read More

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http://dx.doi.org/10.1155/2018/2903139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362475PMC
July 2018
1 Read

Acid-Base Status Disturbances in Patients on Chronic Hemodialysis at High Altitudes.

Int J Nephrol 2018 18;2018:2872381. Epub 2018 Nov 18.

Renal Therapy Service (RTS), Bogotá 110221, Colombia.

Background: Acid-base disorders have been previously described in patients with chronic hemodialysis, with metabolic acidosis being the most important of them; however, little is known about the potential changes in acid-base status of patients on dialysis living at high altitudes.

Methods: Cross-sectional study including 93 patients receiving chronic hemodialysis on alternate days and living in Bogotá, Colombia, at an elevation of 2,640 meters (8,661 feet) over sea level (m.o. Read More

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https://www.hindawi.com/journals/ijn/2018/2872381/
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http://dx.doi.org/10.1155/2018/2872381DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276435PMC
November 2018
25 Reads

A Higher Fructose Intake Is Associated with Greater Albuminuria in Subjects with Type 2 Diabetes Mellitus.

Int J Nephrol 2018 17;2018:5459439. Epub 2018 Oct 17.

Department of Endocrinology and Metabolism, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, 14080 Mexico City, Mexico.

The aim of this single center cross-sectional study was to investigate the association between fructose intake and albuminuria in subjects with type 2 diabetes mellitus (T2DM). This is a single center cross-sectional study. One hundred and forty-three subjects with T2DM were recruited from the Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran. Read More

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https://www.hindawi.com/journals/ijn/2018/5459439/
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http://dx.doi.org/10.1155/2018/5459439DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6207863PMC
October 2018
17 Reads

Prognostic Factors for Survival and Relapse in ANCA-Associated Vasculitis with Renal Involvement: A Clinical Long-Term Follow-Up Study.

Int J Nephrol 2018 16;2018:6369814. Epub 2018 Oct 16.

Abdomen Center, Nephrology, Helsinki University Hospital, Helsinki, Finland.

Aim: We describe the clinical pattern of ANCA-associated vasculitis (AAV) and assess long-term prognostic factors of patients and renal survival and relapse.

Methods: Data from 85 patients with renal biopsy-proven AAV at a single center with up to 20-year [median 16.2 years (95% CI 14. Read More

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https://www.hindawi.com/journals/ijn/2018/6369814/
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http://dx.doi.org/10.1155/2018/6369814DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6206576PMC
October 2018
33 Reads

Glomerulonephritis Pattern at a Jordanian Tertiary Care Center.

Authors:
Randa I Farah

Int J Nephrol 2018 11;2018:2751372. Epub 2018 Oct 11.

Department of Internal Medicine, School of Medicine, University of Jordan, Amman, Jordan.

Aim: To determine the prevalence and frequency of different pathological patterns of glomerulonephritis (GN) in adolescent (age ≥ 11 years) and adult Jordanian patients.

Materials And Methods: A retrospective analysis of all clinical and pathological reports of Jordanian patients who had native renal biopsies at the University of Jordan hospital between January 2007 and March 2018 to assess the prevalence and pathological pattern of GN. The data were analyzed statistically using descriptive statistics, the chi-squared test, and Fisher's exact tests. Read More

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https://www.hindawi.com/journals/ijn/2018/2751372/
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http://dx.doi.org/10.1155/2018/2751372DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201331PMC
October 2018
17 Reads

Cost-Effectiveness Analysis for the Treatment of Hyperphosphatemia in Predialysis Patients: Calcium-Based versus Noncalcium-Based Phosphate Binders.

Int J Nephrol 2018 19;2018:2138528. Epub 2018 Sep 19.

Clinical Research Centre, Serdang Hospital, Kajang 43000, Malaysia.

Background: Hyperphosphatemia in chronic kidney disease (CKD) patients is often treated with calcium carbonate (CaCO3) despite the fact that CaCO3 is associated with increased calcium load and potentially increased cardiovascular risk. Alternative treatments with noncalcium-based phosphate binders do not increase the calcium load but are more costly. This study analyzes the cost-effectiveness of sevelamer versus CaCO3 for the treatment of hyperphosphatemia in stage III-V predialysis CKD patients in Malaysia. Read More

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http://dx.doi.org/10.1155/2018/2138528DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6169205PMC
September 2018
5 Reads

Renal Dysfunction and Recovery following Initial Treatment of Newly Diagnosed Multiple Myeloma.

Int J Nephrol 2018 5;2018:4654717. Epub 2018 Sep 5.

Division of Hematology/Oncology, Rush University Medical Center, Chicago, IL, USA.

Introduction: Renal insufficiency (RI) in Multiple Myeloma (MM) portends a higher tumor burden and worse prognosis. Reversal of RI in newly diagnosed MM (NDMM) improves patient outcomes, but it is unknown if there is a disparity in renal recovery in NDMM between African Americans (AA) and non-African Americans.

Methods: A retrospective chart review was conducted of 690 patients with NDMM at Rush University Medical Center from 2005 to 2016. Read More

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http://dx.doi.org/10.1155/2018/4654717DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6145056PMC
September 2018
2 Reads

Phosphate, Calcification in Blood, and Mineral Stress: The Physiologic Blood Mineral Buffering System and Its Association with Cardiovascular Risk.

Int J Nephrol 2018 2;2018:9182078. Epub 2018 Sep 2.

Department of Nephrology, The Royal Melbourne Hospital, Melbourne, Victoria, Australia.

Phosphate is an important cardiovascular risk factor and lowering elevated blood phosphate concentrations is a main therapeutic target in kidney patients. Phosphate is subject to the which controls the precipitation of calcium and phosphate. Calciprotein particles (CPP), self-assembling complexes of calcium phosphate and serum proteins, are the nanomorphological correlates of this system. Read More

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http://dx.doi.org/10.1155/2018/9182078DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6139212PMC
September 2018
2 Reads

The Urinary Phosphate to Serum Fibroblast Growth Factor 23 Ratio, Deemed the Nephron Index, Is a Useful Clinical Index for Early Stage Chronic Kidney Disease in Patients with Type 2 Diabetes: An Observational Pilot Study.

Int J Nephrol 2018 2;2018:7530923. Epub 2018 Sep 2.

Department of Medicine, Division of Endocrinology and Metabolism, Jichi Medical University Saitama Medical Center, 1-847 Amanuma-cho, Omiya-ku, Saitama 330-8503, Japan.

Renal function decline is associated with progressive type 2 diabetes mellitus, which causes mineral and bone disorders. In the present study, we defined the ratio of urinary phosphate excretion (mg/day) to serum fibroblast growth factor 23 as the nephron index. We examined changes in the nephron index in type 2 diabetes patients with early stage chronic kidney disease (stages 1-3), enrolling 15 patients and retrospectively analysing the follow-up data. Read More

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http://dx.doi.org/10.1155/2018/7530923DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6139210PMC
September 2018
3 Reads

Vascular Calcification in Chronic Kidney Disease: The Role of Inflammation.

Int J Nephrol 2018 13;2018:4310379. Epub 2018 Aug 13.

Department of Nephropathology, Friedrich-Alexander University (FAU) Erlangen-Nürnberg, Germany.

Cardiovascular complications are extremely frequent in patients with chronic kidney disease (CKD) and death from cardiac causes is the most common cause of death in this particular population. Cardiovascular disease is approximately 3 times more frequent in patients with CKD than in other known cardiovascular risk groups and cardiovascular mortality is approximately 10-fold more frequent in patients on dialysis compared to the age- and sex-matched segments of the nonrenal population. Among other structural and functional factors advanced calcification of atherosclerotic plaques as well as of the arterial and venous media has been described as potentially relevant for this high cardiovascular morbidity and mortality. Read More

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http://dx.doi.org/10.1155/2018/4310379DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109995PMC
August 2018
3 Reads

Mortality and Recovery of Renal Function in Acute Kidney Injury Patients Treated with Prolonged Intermittent Hemodialysis Sessions Lasting 10 versus 6 Hours: Results of a Randomized Clinical Trial.

Int J Nephrol 2018 13;2018:4097864. Epub 2018 Aug 13.

Botucatu School of Medicine, University of São Paulo State (UNESP), Brazil.

Purpose: This trial aimed to compare mortality and recovery of renal function in acute kidney injury (AKI) patients treated with different durations of prolonged hemodialysis (PHD) sessions (6 h versus 10 h).

Methodology: We included patients with sepsis-associated AKI, >18 years, who are in use of a norepinephrine (lower than 0.7 ucg/kg/min). Read More

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http://dx.doi.org/10.1155/2018/4097864DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6110015PMC
August 2018
6 Reads

Renal Outcomes in Children with Operated Spina Bifida in Uganda.

Int J Nephrol 2018 7;2018:6278616. Epub 2018 Aug 7.

Department of Paediatric Neurosurgery, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.

Background: To describe the extent of renal disease in Ugandan children surviving at least ten years after spina bifida repair and to investigate risk factors for renal deterioration in this cohort.

Patients And Methods: Children who had undergone spina bifida repair at CURE Children's Hospital of Uganda between 2000 and 2004 were invited to attend interview, physical examination, renal tract ultrasound, and a blood test (creatinine). Medical records were retrospectively reviewed. Read More

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http://dx.doi.org/10.1155/2018/6278616DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6106852PMC
August 2018
2 Reads

Pediatric Nephrology and Rheumatology Practice Patterns in Granulomatosis with Polyangiitis: A Midwest Pediatric Nephrology Consortium Study.

Int J Nephrol 2018 5;2018:8413096. Epub 2018 Aug 5.

Virginia Commonwealth University, Internal Medicine Nephrology, Virginia, USA.

Objective: To assess practice pattern similarities and differences amongst pediatric rheumatologists and nephrologists in the management of pediatric Granulomatosis with Polyangiitis (GPA).

Methods: A voluntary survey was distributed to the Midwest Pediatric Nephrology Consortium Group (MWPNC) and an international pediatric rheumatology email listserv in 2016-2017. Data were collected on general practice characteristics and preferences for induction management under three clinical scenarios (A-C): newly diagnosed GPA with glomerulonephritis, GPA with rapidly progressive glomerulonephritis, and GPA with pulmonary hemorrhage. Read More

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https://www.hindawi.com/journals/ijn/2018/8413096/
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http://dx.doi.org/10.1155/2018/8413096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6098870PMC
August 2018
9 Reads

The Factors Affecting Survival in Geriatric Hemodialysis Patients.

Int J Nephrol 2018 10;2018:5769762. Epub 2018 Jul 10.

Department of Nephrology, Bakirkoy Sadi Konuk Training and Research Hospital, Istanbul, Turkey.

Introduction: The number of geriatric patients is increasing in hemodialysis population over the years and mortality is higher in this group of patients. This study evaluated the factors affecting geriatric hemodialysis patient survival.

Materials And Methods: This retrospective cohort study enrolled patients discharged from our nephrology clinic from 2009 to 2014. Read More

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http://dx.doi.org/10.1155/2018/5769762DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6077547PMC
July 2018
3 Reads

Projecting the Burden of Chronic Kidney Disease in a Developed Country and Its Implications on Public Health.

Int J Nephrol 2018 4;2018:5196285. Epub 2018 Jul 4.

Chronic Disease Epidemiology, Population Health, National Healthcare Group, Singapore.

Background: Chronic Kidney Disease (CKD) is a major public health problem worldwide. There is limited literature on a model to project the number of people with CKD. This study projects the number of residents with CKD in Singapore by 2035 using a Markov model. Read More

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http://dx.doi.org/10.1155/2018/5196285DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6077589PMC
July 2018
2 Reads

Clinical Presentation, Outcomes, and Treatment of Membranous Nephropathy after Transplantation.

Int J Nephrol 2018 5;2018:3720591. Epub 2018 Jul 5.

Federal University of São Paulo (UNIFESP), São Paulo, SP, Brazil.

There are scarce data about clinical presentation and outcomes of posttransplant membranous nephropathy (MN), and few reports include a large number of patients. This was a retrospective cohort including adult patients with posttransplant MN transplanted between 1983 and 2015 in a single center (n=41). Only patients with histological diagnosis of MN in kidney grafts were included. Read More

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http://dx.doi.org/10.1155/2018/3720591DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6077578PMC
July 2018
2 Reads

Characterization and Etiopathogenic Approach of Pediatric Renal Biopsy Patients in a Colombian Medical Center from 2007-2017.

Int J Nephrol 2018 28;2018:9603453. Epub 2018 Jun 28.

Pediatric Nephrology Division, Pediatrics Department, Fundación Cardioinfantil, Bogotá, Cundinamarca, Colombia.

Introduction: Renal biopsy is the principal instrument to evaluate the diagnosis and prognosis of children with kidney disease. There are relatively few studies establishing epidemiology of its findings in the pediatric population.

Methods: A descriptive study was conducted to describe characteristics of pediatric patients who had undergone a renal biopsy over the last 10 years in a national reference center, trying to accomplish an etiopathogenic approach of biopsy findings. Read More

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http://dx.doi.org/10.1155/2018/9603453DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6046137PMC
June 2018
3 Reads

Transforming Growth Factor- Protects against Inflammation-Related Atherosclerosis in South African CKD Patients.

Int J Nephrol 2018 6;2018:8702372. Epub 2018 Jun 6.

Department of Internal Medicine, Faculty of Health Sciences, University of the Witwatersrand, South Africa.

Background: Transforming growth factor- (TGF-) may inhibit the development of atherosclerosis. We evaluated serum levels of TGF- isoforms concurrently with serum levels of endotoxin and various inflammatory markers. In addition, we determined if any association exists between polymorphisms in the gene and atherosclerosis in South African CKD patients. Read More

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https://www.hindawi.com/journals/ijn/2018/8702372/
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http://dx.doi.org/10.1155/2018/8702372DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6011064PMC
June 2018
11 Reads

Microalbuminuria and Retinopathy among Hypertensive Nondiabetic Patients at a Large Public Outpatient Clinic in Southwestern Uganda.

Int J Nephrol 2018 6;2018:4802396. Epub 2018 Jun 6.

Department of Community Health, Mbarara University of Science and Technology, P.O. BOX 1410, Mbarara, Uganda.

Background: Routine testing of microalbuminuria and retinopathy is not done among patients with high blood pressure in resource-limited settings. We determined the prevalence of microalbuminuria and retinopathy and their risk factors among hypertensive patients at a large hospital in western Uganda.

Methods: We consecutively recruited nondiabetic patients with hypertension at the outpatients' clinic over a period of 3 months. Read More

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https://www.hindawi.com/journals/ijn/2018/4802396/
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http://dx.doi.org/10.1155/2018/4802396DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6011089PMC
June 2018
10 Reads

Molecular Mechanisms Underlying Accelerated Aging by Defects in the FGF23-Klotho System.

Authors:
Makoto Kuro-O

Int J Nephrol 2018 21;2018:9679841. Epub 2018 May 21.

Division of Anti-Aging Medicine, Center for Molecular Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan.

The basic research of aging has been primarily focused on elucidating mechanisms of aging and longevity that are evolutionarily conserved from yeasts to primates. Such efforts have culminated in the notion that (1) senescence at the cellular level is associated with aging at the organismal level and that (2) calorie restriction and growth suppression decelerate aging. However, these important findings in the basic research have not necessarily been linked to improvement of daily medical practice in the aging society. Read More

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http://dx.doi.org/10.1155/2018/9679841DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987335PMC
May 2018
29 Reads

Association of Poor Social Support and Financial Insecurity with Psychological Distress of Chronic Kidney Disease Patients Attending National Nephrology Unit in Sri Lanka.

Int J Nephrol 2018 16;2018:5678781. Epub 2018 May 16.

Department of Public Health, Faculty of Medicine, University of Kelaniya, Colombo, Sri Lanka.

Background: Chronic kidney disease (CKD) is associated with high morbidity and mortality. Hence, CKD patients are often in chronic psychological distress. The objective of the study was to describe factors associated with psychological distress of CKD patients attending National Nephrology Unit. Read More

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http://dx.doi.org/10.1155/2018/5678781DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5977053PMC
May 2018
2 Reads

Estimating Renal Function in the Elderly Malaysian Patients Attending Medical Outpatient Clinic: A Comparison between Creatinine Based and Cystatin-C Based Equations.

Int J Nephrol 2018 13;2018:3081518. Epub 2018 May 13.

Department of Medicine, University of Malaya Medical Centre, 59100 Kuala Lumpur, Malaysia.

Background: To assess the performance of different GFR estimating equations, test the diagnostic value of serum cystatin-C, and compare the applicability of cystatin-C based equation with serum creatinine based equation for estimating GFR (eGFR) in comparison with measured GFR in the elderly Malaysian patients.

Methods: A cross-sectional study recruiting volunteered patients 65 years and older attending medical outpatient clinic. 51 chromium EDTA (Cr-EDTA) was used as measured GFR. Read More

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http://dx.doi.org/10.1155/2018/3081518DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5971237PMC
May 2018
2 Reads

Undiagnosed Kidney Injury in Uninsured and Underinsured Diabetic African American Men and Putative Role of Meprin Metalloproteases in Diabetic Nephropathy.

Int J Nephrol 2018 29;2018:6753489. Epub 2018 Apr 29.

Department of Biology, North Carolina A&T State University, Greensboro, NC 27411, USA.

Diabetes is the leading cause of chronic kidney disease. African Americans are disproportionately burdened by diabetic kidney disease (DKD) and end stage renal disease (ESRD). Disparities in DKD have genetic and socioeconomic components, yet its prevalence in African Americans is not adequately studied. Read More

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https://www.hindawi.com/journals/ijn/2018/6753489/
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http://dx.doi.org/10.1155/2018/6753489DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5949186PMC
April 2018
4 Reads

Contrast-Induced Nephropathy: Update on the Use of Crystalloids and Pharmacological Measures.

Int J Nephrol 2018 2;2018:5727309. Epub 2018 May 2.

Innere Medizin I, Kardiologie, Angiologie, Nephrologie, Klinikum Brandenburg, Medizinische Hochschule Brandenburg, Brandenburg, Germany.

Contrast-induced nephropathy (CIN) is a frequent and severe complication in subjects receiving iodinated contrast media for diagnostic or therapeutic purposes. Several preventive strategies were evaluated in the past. Recent clinical studies and meta-analyses delivered some new aspects on preventive measures used in the past and present. Read More

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http://dx.doi.org/10.1155/2018/5727309DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5954945PMC
May 2018
1 Read

Phosphate and Cardiovascular Disease beyond Chronic Kidney Disease and Vascular Calcification.

Int J Nephrol 2018 8;2018:3162806. Epub 2018 Apr 8.

Division of Nephrology, Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

Phosphate is essential for life but its accumulation can be detrimental. In end-stage renal disease, widespread vascular calcification occurs as a result of chronic phosphate load. The accumulation of phosphate is likely to occur long before the rise in serum phosphate above the normal range since several observational studies in both general population and early-stage CKD patients have identified the relationship between high-normal serum phosphate and adverse cardiovascular outcomes. Read More

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http://dx.doi.org/10.1155/2018/3162806DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5911324PMC
April 2018
33 Reads

A Web-Based Platform to Collect Data from ESRD Patients Undergoing Dialysis: Methods and Preliminary Results from the Brazilian Dialysis Registry.

Int J Nephrol 2018 5;2018:9894754. Epub 2018 Mar 5.

Universidade Federal de São Paulo, São Paulo, SP, Brazil.

Introduction: The methods and initial results of a web-based platform to collect data from patients receiving maintenance dialysis in Brazil are reported.

Methods: Companies providing management software for dialysis centers adapted their system to comply with a formulary of the Brazilian Society of Nephrology. Baseline and follow-up individual patients' data were transmitted via Internet on monthly bases to the coordinating center from 2011 to 2017. Read More

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http://dx.doi.org/10.1155/2018/9894754DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859861PMC
March 2018
5 Reads

Murine Nephrotoxic Nephritis as a Model of Chronic Kidney Disease.

Int J Nephrol 2018 5;2018:8424502. Epub 2018 Mar 5.

Department of Diabetes Complications Pharmacology, Novo Nordisk, Maaloev, Denmark.

Using the nonaccelerated murine nephrotoxic nephritis (NTN) as a model of chronic kidney disease (CKD) could provide an easily inducible model that enables a rapid test of treatments. Originally, the NTN model was developed as an acute model of glomerulonephritis, but in this study we evaluate the model as a CKD model and compare CD1 and C57BL/6 female and male mice. CD1 mice have previously showed an increased susceptibility to CKD in other CKD models. Read More

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http://dx.doi.org/10.1155/2018/8424502DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859794PMC
March 2018
4 Reads

Prevalence of Microalbuminuria in Adult Patients with Sickle Cell Disease in Eastern Saudi Arabia.

Int J Nephrol 2018 27;2018:5015764. Epub 2018 Feb 27.

Royal College of Surgeons in Ireland, Dublin, Ireland.

Background: Proteinuria is a common feature of sickle cell nephropathy (SCN) that can progress to renal insufficiency and end stage renal disease. Microalbuminuria (MA) is the earliest manifestation of SCN and precedes the development of overt proteinuria. In addition to the renal consequences, MA is linked to cardiovascular complications. Read More

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http://dx.doi.org/10.1155/2018/5015764DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5848055PMC
February 2018
7 Reads

Restless Legs Syndrome in Dialysis Patients: Does the Dialysis Modality Influence Its Occurrence and Severity?

Int J Nephrol 2018 25;2018:1414568. Epub 2018 Feb 25.

Postgraduate Program in Health Sciences, Federal University of Sergipe, São Cristóvão, SE, Brazil.

Background: Restless legs syndrome (RLS) is more prevalent in chronic kidney patients than in the general population, but it is often diagnosed late and its predictors are unknown.

Purpose: To diagnose RLS in a group of chronic kidney patients on dialysis, determine its frequency and severity, compare the prevalence and severity of the condition among dialytic modalities, and identify possible predictive factors in this population.

Methods: An observational and cross-sectional study with 326 patients who had been on dialysis for more than 3 months, 241 on hemodialysis (HD) and 85 on automatic peritoneal dialysis (APD), using the criteria established by the International Study Group on RLS for the diagnosis and the RLS Rating Scale to determine its severity. Read More

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http://dx.doi.org/10.1155/2018/1414568DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5845496PMC
February 2018
9 Reads

Low, rather than High, Body Mass Index Is a Risk Factor for Acute Kidney Injury in Multiethnic Asian Patients: A Retrospective Observational Study.

Int J Nephrol 2018 9;2018:3284612. Epub 2018 Jan 9.

Division of Renal Medicine, Department of General Medicine, Khoo Teck Puat Hospital, Singapore.

Background: Acute kidney injury (AKI) is common in hospitalised patients. The relationship between body mass index (BMI) and the risk of having AKI for patients in the acute hospital setting is not known, particularly in the Asian population.

Methods: This was a retrospective, single-centre, observational study conducted in Singapore, a multiethnic population. Read More

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http://dx.doi.org/10.1155/2018/3284612DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5818948PMC
January 2018
4 Reads

Cancer in ANCA-Associated Glomerulonephritis: A Registry-Based Cohort Study.

Int J Nephrol 2017 18;2017:6013038. Epub 2017 Dec 18.

Department of Clinical Medicine, University of Bergen, Bergen, Norway.

Background: Immunosuppressive therapy for antineutrophil cytoplasmic antibody-associated vasculitis has been associated with increased malignancy risk.

Objectives: To quantify the cancer risk associated with contemporary cyclophosphamide-sparing protocols.

Methods: Patients from the Norwegian Kidney Biopsy Registry between 1988 and 2012 who had biopsy-verified pauci-immune glomerulonephritis and positive antineutrophil cytoplasmic antibody (ANCA) serology were included. Read More

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http://dx.doi.org/10.1155/2017/6013038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748316PMC
December 2017
7 Reads

Serial Galactose-Deficient IgA1 Levels in Children with IgA Nephropathy and Healthy Controls.

Int J Nephrol 2017 26;2017:8210641. Epub 2017 Nov 26.

University of Tennessee Health Sciences Center, Memphis, TN 38013, USA.

Galactose-deficient IgA1 (Gd-IgA1) is a key pathogenic factor for IgA nephropathy (IgAN) and a potential biomarker for the disease. This study examined serial serum Gd-IgA1 levels over 1 year in 13 children with IgAN and 40 healthy children, to determine whether or not serum Gd-IgA1 levels changed over time. Subjects were younger than 18 years of age. Read More

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https://www.hindawi.com/journals/ijn/2017/8210641/
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http://dx.doi.org/10.1155/2017/8210641DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5733148PMC
November 2017
6 Reads

Dialysis Provision and Implications of Health Economics on Peritoneal Dialysis Utilization: A Review from a Malaysian Perspective.

Int J Nephrol 2017 31;2017:5819629. Epub 2017 Oct 31.

Hospital Kuala Lumpur, Jalan Pahang, 50586 Kuala Lumpur, Malaysia.

End-stage renal disease (ESRD) is managed by either lifesaving hemodialysis (HD) and peritoneal dialysis (PD) or a kidney transplant. In Malaysia, the prevalence of dialysis-treated ESRD patients has shown an exponential growth from 504 per million population (pmp) in 2005 to 1155 pmp in 2014. There were 1046 pmp patients on HD and 109 pmp patients on PD in 2014. Read More

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http://dx.doi.org/10.1155/2017/5819629DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5684550PMC
October 2017
10 Reads

Complex Monitoring of Biochemical and Radionuclide Parameters in Patients with Metastatic Renal Cell Carcinoma during Immunotherapy.

Int J Nephrol 2017 22;2017:8549502. Epub 2017 Oct 22.

A. Tsyb Medical Radiological Research Centre, Branch of the National Medical Research Radiological Centre of The Ministry of Health of The Russian Federation, 10 Zhukov St., Obninsk, Kaluga 249036, Russia.

Study Objective: To study the effectiveness of complex monitoring of the kidney function, based on biochemical and radionuclide methods in patients with metastatic renal cell carcinoma (mRCC).

Materials And Methods: 41 mRCC patients after nephrectomy received nivolumab ( = 23) and interferon- ( = 18) from 2015 to 2017. At baseline and 2 months after, all patients underwent blood chemistry, urinalysis, Rehberg test, and ELISA to determine serum levels of IL-17A, TGF-, and erythropoietin. Read More

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http://dx.doi.org/10.1155/2017/8549502DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5671726PMC
October 2017
12 Reads

NT-proBNP, Cardiometabolic Risk Factors, and Nutritional Status in Hemodialysis Patients.

Int J Nephrol 2017 17;2017:1312547. Epub 2017 Sep 17.

Centre de Dialyse AUDRA, Hôpital RICOU, Pointe-à-Pitre, Guadeloupe, France.

Background: We aimed to evaluate the association between NT-proBNP and malnutrition in HD patients while taking into account the four established categories of parameters for diagnosis of protein energy wasting (PEW).

Methods: A cross-sectional study was performed in Afro-Caribbean dialysis patients. One component in each of the 4 categories for the wasting syndrome was retained: serum albumin ≤ 38 g/L, BMI ≤ 23 Kg/m, serum creatinine ≤ 818 mol/L, and normalized protein catabolic rate (nPCR) ≤ 0. Read More

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http://dx.doi.org/10.1155/2017/1312547DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5623768PMC
September 2017
4 Reads

The Role of Sodium Bicarbonate in the Management of Some Toxic Ingestions.

Int J Nephrol 2017 8;2017:7831358. Epub 2017 Aug 8.

Department of Medicine, University of Kentucky College of Medicine, Lexington, KY, USA.

Adverse reactions to commonly prescribed medications and to substances of abuse may result in severe toxicity associated with increased morbidity and mortality. According to the Center for Disease Control, in 2013, at least 2113 human fatalities attributed to poisonings occurred in the United States of America. In this article, we review the data regarding the impact of systemic sodium bicarbonate administration in the management of certain poisonings including sodium channel blocker toxicities, salicylate overdose, and ingestion of some toxic alcohols and in various pharmacological toxicities. Read More

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http://dx.doi.org/10.1155/2017/7831358DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5591930PMC
August 2017
19 Reads

Denosumab for Male Hemodialysis Patients with Low Bone Mineral Density: A Case-Control Study.

Int J Nephrol 2017 22;2017:6218129. Epub 2017 Aug 22.

Saiyu Souka Clinic, Souka, Japan.

Denosumab increases bone mineral density (BMD) in patients not receiving hemodialysis therapy. However, limited data are available in the literature concerning the use of denosumab in hemodialysis patients. We treated male hemodialysis patients with low radius BMD with denosumab therapy for 1 year and evaluated its effect on radius BMD. Read More

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http://dx.doi.org/10.1155/2017/6218129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5585574PMC
August 2017
6 Reads

Sleep Parameters in Short Daily versus Conventional Dialysis: An Actigraphic Study.

Int J Nephrol 2017 17;2017:2473217. Epub 2017 Aug 17.

Universidade de Brasília (UnB), Brasília, DF, Brazil.

Previous studies have observed worse sleep quality in patients undergoing conventional dialysis as compared to daily dialysis. Our aim was to compare the sleep parameters of patients undergoing daily or conventional dialysis using an objective measure (actigraphy). This cross-sectional study was performed in three dialysis centers, including a convenience sample (nonprobability sampling) of 73 patients (36 patients on daily hemodialysis and 37 patients on conventional hemodialysis). Read More

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https://www.hindawi.com/journals/ijn/2017/2473217/
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http://dx.doi.org/10.1155/2017/2473217DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5585576PMC
August 2017
18 Reads

Analysis of T Cell Subsets in Adult Primary/Idiopathic Minimal Change Disease: A Pilot Study.

Int J Nephrol 2017 15;2017:3095425. Epub 2017 Aug 15.

Singapore Immunology Network (SIGN), Agency for Science, Technology and Research (ASTAR), Biopolis, Singapore.

Aim: To characterise infiltrating T cells in kidneys and circulating lymphocyte subsets of adult patients with primary/idiopathic minimal change disease.

Methods: In a cohort of 9 adult patients with primary/idiopathic minimal change recruited consecutively at disease onset, we characterized (1) infiltrating immune cells in the kidneys using immunohistochemistry and (2) circulating lymphocyte subsets using flow cytometry. As an exploratory analysis, association of the numbers and percentages of both kidney-infiltrating immune cells and the circulating lymphocyte subsets with kidney outcomes including deterioration of kidney function and proteinuria, as well as time to complete clinical remission up to 48 months of follow-up, was investigated. Read More

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http://dx.doi.org/10.1155/2017/3095425DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5574215PMC
August 2017
50 Reads

Malignancy in Membranous Nephropathy: Evaluation of Incidence.

Int J Nephrol 2017 16;2017:8409829. Epub 2017 Jul 16.

Department of Pathology, Auckland City Hospital, 2 Park Drive, Grafton, Auckland 1023, New Zealand.

Background: Membranous nephropathy (MN) can be associated with malignancy. However, the relative risk for malignancy remains unclear. It has been reported that higher numbers of inflammatory cells seen in the glomeruli at biopsy correlate with the occurrence of malignancy in patients with MN and might be used to direct screening. Read More

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http://dx.doi.org/10.1155/2017/8409829DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5534270PMC
July 2017
5 Reads

Comparative Performance of Creatinine-Based Estimated Glomerular Filtration Rate Equations in the Malays: A Pilot Study in Tertiary Hospital in Malaysia.

Int J Nephrol 2017 18;2017:2901581. Epub 2017 Jun 18.

University Malaya Medical Centre, 59100 Kuala Lumpur, Malaysia.

Aim: To validate the accuracy of estimated glomerular filtration rate (eGFR) equations in Malay population attending our hospital in comparison with radiolabeled measured GFR.

Methods: A cross-sectional study recruiting volunteered patients in the outpatient setting. Chromium EDTA (51Cr-EDTA) was used as measured GFR. Read More

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http://dx.doi.org/10.1155/2017/2901581DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5494118PMC
June 2017
24 Reads

End-Stage Kidney Failure in Oman: An Analysis of Registry Data with an Emphasis on Congenital and Inherited Renal Diseases.

Int J Nephrol 2017 8;2017:6403985. Epub 2017 Jun 8.

Institute of Genetic Medicine, Newcastle University, Central Parkway, Newcastle upon Tyne NE1 3BZ, UK.

Globally, end-stage kidney disease (ESKD) is a huge burden on health care systems. The aims of this study were to perform a comprehensive epidemiological and etiological report of ESKD patients commencing RRT in Oman with an emphasis on genetic causes and inherited kidney disease. All newly registered Omani patients with ESKD commencing RRT from 2001 until 2015 ( = 2,922) were analysed using the RRT register in Oman. Read More

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http://dx.doi.org/10.1155/2017/6403985DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5480059PMC
June 2017
15 Reads

Gum Arabic Reduces C-Reactive Protein in Chronic Kidney Disease Patients without Affecting Urea or Indoxyl Sulfate Levels.

Int J Nephrol 2017 14;2017:9501470. Epub 2017 May 14.

King Fahad Specialist Hospital, Dammam 31444, Saudi Arabia.

Introduction: Gum Arabic (GA) is a complex polysaccharide with proven prebiotic properties and potentially beneficial systemic effects.

Methods: We randomly allocated 36 chronic kidney disease (CKD) patients to receive 10, 20, or 40 grams daily of GA for four weeks and studied the systemic effects of this intervention.

Results: Thirty participants completed the study with baseline glomerular filtration rate 29. Read More

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http://dx.doi.org/10.1155/2017/9501470DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5446885PMC
May 2017
14 Reads

R229Q Polymorphism of NPHS2 Gene in Group of Iraqi Children with Steroid-Resistant Nephrotic Syndrome.

Int J Nephrol 2017 26;2017:1407506. Epub 2017 Apr 26.

College of Medicine, Al-Nahrain University, Baghdad, Iraq.

. The polymorphism R229Q is one of the most commonly reported podocin sequence variations among steroid-resistant nephrotic syndromes (SRNS). . Read More

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http://dx.doi.org/10.1155/2017/1407506DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5424166PMC
April 2017
33 Reads

Expression of uPAR in Urinary Podocytes of Patients with Fabry Disease.

Int J Nephrol 2017 24;2017:1287289. Epub 2017 Apr 24.

IFIBIO Houssay, CONICET, Physiopathology, Pharmacy and Biochemistry Faculty, Universidad de Buenos Aires, Buenos Aires, Argentina.

. Despite enzyme replacement therapy, Fabry nephropathy still progresses. Podocyturia is an irreversible event that antedates proteinuria and leads to chronic renal failure. Read More

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http://dx.doi.org/10.1155/2017/1287289DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5420917PMC
April 2017
24 Reads