6,657 results match your criteria International journal of molecular medicine[Journal]


Ginsenoside Rg1 protects against H2O2‑induced neuronal damage due to inhibition of the NLRP1 inflammasome signalling pathway in hippocampal neurons in vitro.

Int J Mol Med 2018 Nov 30. Epub 2018 Nov 30.

Department of Pharmacology, Key Laboratory of Anti‑inflammatory and Immunopharmacology, Ministry of Education, Anhui Medical University, Hefei, Anhui 230032, P.R. China.

Oxidative stress and neuroinflammation are important in the pathogenesis of ageing and age‑related neurodegenerative diseases, including Alzheimer's disease. NADPH oxidase 2 (NOX2) is a major source of reactive oxygen species (ROS) in the brain. The nucleotide‑binding oligomerisation domain (NOD)‑like receptor protein 1 (NLRP1) inflammasome is responsible for the formation of pro‑inflammatory molecules in neurons. Read More

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http://dx.doi.org/10.3892/ijmm.2018.4005DOI Listing
November 2018
1 Read

Baicalin inhibits proliferation and promotes apoptosis of vascular smooth muscle cells by regulating the MEG3/p53 pathway following treatment with ox‑LDL.

Int J Mol Med 2018 Nov 30. Epub 2018 Nov 30.

Department of Pharmacy, The First People's Hospital of Lianyungang, Lianyungang, Jiangsu 222002, P.R. China.

Atherosclerosis (AS) is a systemic disease associated with lipid metabolic disorders and abnormal proliferation of smooth muscle cells. Baicalin is a flavonoid compound isolated from the dry roots of Scutellaria baicalensis Georgi and exerts anti‑proliferative effects in various types of cells. However, the effect of baicalin on AS remains unclear. Read More

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http://dx.doi.org/10.3892/ijmm.2018.4009DOI Listing
November 2018

Roles and mechanisms of action of HNF‑4α in the hepatic differentiation of WB‑F344 cells.

Int J Mol Med 2018 Dec 3. Epub 2018 Dec 3.

Department of General Surgery, Tongji Hospital, Tongji University Medical School, Shanghai 200065, P.R. China, P.R. China.

Hepatocyte nuclear factor 4 α (HNF‑4α) is a nuclear receptor and mediates hepatic genes. WB‑F344 liver epithelial cells can differentiate into hepatocytes. The present study aimed to examine the roles and mechanisms of action of HNF‑4α on the hepatic differentiation of WB‑F344 cells. Read More

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http://www.spandidos-publications.com/10.3892/ijmm.2018.4010
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http://dx.doi.org/10.3892/ijmm.2018.4010DOI Listing
December 2018
1 Read

Adipose extracellular matrix promotes skin wound healing by inducing the differentiation of adipose‑derived stem cells into fibroblasts.

Int J Mol Med 2018 Nov 30. Epub 2018 Nov 30.

Department of Plastic and Reconstructive Surgery, General Hospital of Chinese PLA, Beijing 100853, P.R. China.

Fibroblasts are the major effector cells of skin wound healing. Adipose‑derived stem cells can differentiate into fibroblasts under certain conditions. In the present study, it was hypothesized that adipose‑derived stem cells (ADSCs) could be induced by the adipose extracellular matrix (ECM) to differentiate into fibroblasts in order to promote skin wound healing. Read More

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http://dx.doi.org/10.3892/ijmm.2018.4006DOI Listing
November 2018

Astragaloside IV promotes the proliferation and migration of osteoblast-like cells through the hedgehog signaling pathway.

Int J Mol Med 2018 Dec 3. Epub 2018 Dec 3.

Department of Dental Implant Center, Beijing Stomatological Hospital, School of Stomatology, Capital Medical University, Beijing 100050, P.R. China.

The present study aimed to investigate the effects of astragaloside IV on osteoblast‑like cell proliferation and migration, in addition to the underlying signaling pathway. In order to observe the effect on proliferation, a Cell Counting Kit‑8 assay and flow cytometry were used. To detect cell migration ability, cell scratch and Transwell cell migration assays were performed. Read More

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http://dx.doi.org/10.3892/ijmm.2018.4013DOI Listing
December 2018

Cryptotanshinone induces reactive oxygen species‑mediated apoptosis in human rheumatoid arthritis fibroblast‑like synoviocytes.

Int J Mol Med 2018 Dec 3. Epub 2018 Dec 3.

Department of Biochemistry and Molecular Biology, College of Life Science and Technology, Heilongjiang Bayi Agricultural University, Daqing, Heilongjiang 163319, P.R. China.

The present study investigated the mechanisms of apoptosis induced by cryptotanshinone (CT) in human rheumatoid arthritis fibroblast‑like synoviocytes (RA‑FLSs). Cell Counting kit‑8 assay was performed to determine the cytotoxic effects of CT in human RA‑FLSs, including primary RA‑FLS, HFLS‑RA and MH7A cells, and in HFLS cells derived from normal synovial tissue. Annexin V‑FITC/PI staining was used to detect the apoptotic effects of CT in HFLS‑RA and MH7A cells. Read More

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http://dx.doi.org/10.3892/ijmm.2018.4012DOI Listing
December 2018
1.880 Impact Factor

MicroRNA‑124‑3p attenuates severe community‑acquired pneumonia progression in macrophages by targeting tumor necrosis factor receptor‑associated factor 6.

Int J Mol Med 2018 Dec 3. Epub 2018 Dec 3.

Department of Critical Care Medicine, The Second Hospital of Shandong University, Jinan, Shandong 250033, P.R. China.

Community‑acquired pneumonia (CAP) is a severe type of pneumonia in adults, with a high mortality rate. Macrophages have been reported to mediate severe CAP (SCAP) in vitro following administration of LPS. Therefore, the present study established a SCAP model in Ana‑1 macrophages by lipopolysaccharide (LPS) induction, and aimed to explore the function of microRNA (miR)‑124‑3p in the LPS‑induced SCAP. Read More

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http://dx.doi.org/10.3892/ijmm.2018.4011DOI Listing
December 2018

MicroRNA-497 inhibits multiple myeloma growth and increases susceptibility to bortezomib by targeting Bcl-2.

Int J Mol Med 2018 Dec 7. Epub 2018 Dec 7.

Department of Hematology, Longgang District People's Hospital of Shenzhen, Shenzhen, Guangdong 518172, P.R. China.

Multiple myeloma (MM) is a common severe hematopoietic malignancy occuring in aged population. MicroRNA (miR)‑497 was previously reported to contribute to the apoptosis of other cell types, presumably through targeting B‑cell lymphoma 2 (Bcl‑2). In the present study, miRNA and protein expression levels were detected by reverse transcription‑quantitative polymerase chain reaction and western blot analyses, respectively. Read More

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http://dx.doi.org/10.3892/ijmm.2018.4019DOI Listing
December 2018

Akt3 is a target of miR-29c-3p and serves an important function in the pathogenesis of congenital heart disease.

Int J Mol Med 2018 Nov 30. Epub 2018 Nov 30.

Department of Cardiothoracic Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China.

Our previous studies identified that the expression of microRNA‑29c (miR‑29c‑3p) was significantly increased in the serum of pregnant women carrying fetuses with congenital heart disease (CHD) compared with in that of normal pregnant women. However, the mechanism by which miR‑29c‑3p affects development of the embryonic heart remained unclear. The aim of the present study was to investigate the effect and potential molecular mechanism of miR‑29c‑3p overexpression on P19 cell proliferation, apoptosis and differentiation. Read More

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http://dx.doi.org/10.3892/ijmm.2018.4008DOI Listing
November 2018

MicroRNA-323 suppresses nerve cell toxicity in cerebral infarction via the transforming growth factor-β1/SMAD3 signaling pathway.

Int J Mol Med 2018 Dec 7. Epub 2018 Dec 7.

Department of Neurology, Beijing Luhe Hospital Capital Medical University, Beijing 101145, P.R. China.

In the present study, the aim was to investigate the function of microRNA‑323 (miR‑323) in cerebral infarction and its underlying mechanism. A rat model of cerebral infarction was established and hippocampal tissues were analyzed. In addition, to further understand the role of miR‑323, PC12 cells were transfected with miR‑323 mimics or inhibitors and subjected to hypoxia to model cerebral infarction. Read More

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http://dx.doi.org/10.3892/ijmm.2018.4020DOI Listing
December 2018

Cyr61 decreases Cytarabine chemosensitivity in acute lymphoblastic leukemia cells via NF-κB pathway activation.

Int J Mol Med 2018 Dec 6. Epub 2018 Dec 6.

Department of Laboratory Medicine, Fujian Medical University Union Hospital, Fuzhou, Fujian 350001, P.R. China.

Elevated Cyr61 levels have been reported in various malignancies. Elevation of Cyr61 protein levels contributes to the proliferation, metastasis, and chemotherapy resistance of malignant cells. Previously, it was discovered that Cyr61 is elevated in both the plasma and the bone marrow supernatants of patients with acute lymphoblastic leukemia (ALL), promoting ALL cell survival. Read More

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http://dx.doi.org/10.3892/ijmm.2018.4018DOI Listing
December 2018

The AIB1siRNA-loaded hyaluronic acid-assembled PEI/heparin/Ca2+ nanocomplex as a novel therapeutic strategy in lung cancer treatment.

Int J Mol Med 2018 Dec 3. Epub 2018 Dec 3.

Department of Respiratory Medicine, Yanbian University Hospital, Yanji, Jilin 133000, P.R. China.

In the present study, AIB1siRNA‑loaded polyethyleneimine (PEI)/heparin/Ca2+ nanoparticles (NPs) were successfully prepared and evaluated for their efficacy in lung cancer cells. The results demonstrated that the PEI and heparin complex reduced the toxic effect in cancer cells while maintaining its transfection efficiency. A nanosized particle of ~25 nm was formulated and siRNA was demonstrated to possess excellent binding efficiency in the particles. Read More

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http://dx.doi.org/10.3892/ijmm.2018.4014DOI Listing
December 2018

Inhibition of protein kinase CK2 facilitates cellular senescence by inhibiting the expression of HO-1 in articular chondrocytes.

Int J Mol Med 2018 Dec 4. Epub 2018 Dec 4.

Department of Microbiology and Immunology, Pusan National University School of Medicine, Yangsan, Gyeongnam 50612, Republic of Korea.

Protein kinase casein kinase 2 (CK2) is important in the regulation of cell proliferation and death, even under pathological conditions. Previously, we reported that CK2 regulates the expression of heme oxygenase‑1 (HO‑1) in stress‑induced chondrocytes. In the present study, it was shown that CK2 is involved in the dedifferentiation and cellular senescence of chondrocytes. Read More

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http://dx.doi.org/10.3892/ijmm.2018.4016DOI Listing
December 2018

Expression of microRNA‑27a in a rat model of osteonecrosis of the femoral head and its association with TGF‑β/Smad7 signalling in osteoblasts.

Int J Mol Med 2018 Nov 30. Epub 2018 Nov 30.

Second Department of Orthopaedics, Cangzhou Central Hospital, Cangzhou, Hebei 061000, P.R. China.

The present study assessed whether microRNA (miR)‑27a is an influential factor in steroid‑induced osteonecrosis of the femoral head (ONFH) and investigated the underlying mechanism of action. The results indicated that serum miR‑27a was decreased in a rat model of ONFH compared with that in control rats. It was also observed that increased miR‑27a expression promoted osteogenic differentiation and cell proliferation, inhibited caspase‑3/9 and B‑cell lymphoma‑2‑associated X protein expression and induced alkaline phosphatase (ALP) activity and bone morphogenetic protein (BMP)‑2, runt‑related transcription factor (Runx)2 and osteonectin mRNA expression in osteoblastic MC3T3‑E1 cells. Read More

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http://dx.doi.org/10.3892/ijmm.2018.4007DOI Listing
November 2018

MicroRNA‑100‑5p inhibits osteoclastogenesis and bone resorption by regulating fibroblast growth factor 21.

Int J Mol Med 2018 Dec 6. Epub 2018 Dec 6.

Department of Orthopedic Surgery, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, P.R. China.

MicroRNAs (miRNAs/miRs) are post‑transcriptional regulators that serve important roles in osteoclastogenesis and bone metabolism; however, the roles of miRNAs have not been completely clarified. The present study aimed to investigate the effects of miR‑100‑5p on the mechanism of liver‑bone endocrine metabolism. A miRNA microarray analysis was conducted to evaluate the miRNA expression profile during receptor activator of nuclear factor‑κB ligand‑stimulated osteoclastogenesis. Read More

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http://dx.doi.org/10.3892/ijmm.2018.4017DOI Listing
December 2018

Atorvastatin downregulates HSP22 expression in an atherosclerotic model in vitro and in vivo.

Int J Mol Med 2018 Dec 3. Epub 2018 Dec 3.

Department of Cardiology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China.

One of the pathological functions of heat shock protein 22 (HSP22) is the association with inflammatory diseases and atherosclerosis. However, the effects of a high‑fat diet (HFD) or oxidized low‑density lipoprotein (ox‑LDL) combined with atorvastatin (ATV) on HSP22 expression are entirely unknown. The present study investigated the effects of ATV on HSP22 expression in HFD‑induced atherosclerotic apolipoprotein E‑deficient (ApoE‑/‑) mice and in ox‑LDL‑induced human umbilical vein endothelial cells (HUVECs). Read More

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http://dx.doi.org/10.3892/ijmm.2018.4015DOI Listing
December 2018

Expression of FKBP52 in the ovaries of PCOS rats.

Int J Mol Med 2018 Nov 26. Epub 2018 Nov 26.

Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210029, P.R. China.

The present study aimed to examine the expression of FK‑506 binding protein 52 (FKBP52) in the ovary tissues of rats with polycystic ovarian syndrome (PCOS) and its action on mediating androgen receptor (AR) through the mitogen‑activated protein kinase (MAPK)/extracellular signal‑regulated kinase (ERK) pathway. PCOS model rats were established by dehydroepiandrosterone injection. Enzyme‑linked immunosorbent assay (ELISA) measured serum sex hormones. Read More

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http://dx.doi.org/10.3892/ijmm.2018.3998DOI Listing
November 2018
1 Read

Downregulation of Blimp1 inhibits the maturation of bone marrow-derived dendritic cells.

Int J Mol Med 2018 Nov 26. Epub 2018 Nov 26.

Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, P.R. China.

Modulation of differentiation of dendritic cells (DCs), which are derived from bone marrow cells, may influence their maturation and consequently regulate their ability to present antigens to alloreactive T lymphocytes. B lymphocyte‑induced maturation protein‑1 (Blimp1) is a master regulator of immunocyte differentiation, which has been investigated for its effect on DCs. In the present study, a lentivirus was used as a vector to transduce Blimp1‑short hairpin (sh)RNA into primary bone marrow cells during their differentiation to DCs. Read More

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http://dx.doi.org/10.3892/ijmm.2018.4000DOI Listing
November 2018

Insulin gene enhancer binding protein 1 induces adipose tissue‑derived stem cells to differentiate into pacemaker‑like cells.

Int J Mol Med 2018 Nov 27. Epub 2018 Nov 27.

Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China.

Hybrid approaches combining gene‑ and cell‑based therapies to make biological pacemakers are a promising therapeutic avenue for bradyarrhythmia. The present study aimed to direct adipose tissue‑derived stem cells (ADSCs) to differentiate specifically into cardiac pacemaker cells by overexpressing a single transcription factor, insulin gene enhancer binding protein 1 (ISL‑1). In the present study, the ADSCs were transfected with ISL‑1 or mCherry fluorescent protein lentiviral vectors and co‑cultured with neonatal rat ventricular cardiomyocytes (NRVMs) in vitro for 5‑7 days. Read More

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http://dx.doi.org/10.3892/ijmm.2018.4002DOI Listing
November 2018
2 Reads
1.880 Impact Factor

AngiomiRs: MicroRNAs driving angiogenesis in cancer (Review).

Int J Mol Med 2018 Nov 27. Epub 2018 Nov 27.

Posgrado en Ciencias Genomicas, Universidad Autonoma de la Ciudad de Mexico, Ciudad de Mexico 03100, Mexico.

Angiogenesis is an important hallmark of cancer serving a key role in tumor growth and metastasis. Therefore, tumor angiogenesis has become an attractive target for development of novel drug therapies. An increased amount of anti‑angiogenic compounds is currently in preclinical and clinical development for personalized therapies. Read More

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http://dx.doi.org/10.3892/ijmm.2018.4003DOI Listing
November 2018

Dynamic expression of SMAD3 is critical in osteoblast differentiation of PDMCs.

Int J Mol Med 2018 Nov 26. Epub 2018 Nov 26.

School of Medicine, College of Medicine, Fu Jen Catholic University, New Taipei City 24205, Taiwan, R.O.C.

Human pluripotent stem cells have the potential assist in the identification of genes involved in mammalian development. The human placenta is considered a repository of stem cells, termed placenta‑derived multipotent cells (PDMCs), which are able to differentiate into cells with an osteoblastic phenotype. This plasticity of PDMCs maybe applied clinically to the understanding of osteogenesis and osteoporosis. Read More

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http://dx.doi.org/10.3892/ijmm.2018.4001DOI Listing
November 2018
3 Reads

An integrative theory for cancer (Review).

Authors:
Guopei Luo Na Liu

Int J Mol Med 2018 Nov 28. Epub 2018 Nov 28.

Department of Psychiatry, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, P.R. China.

In the integrative theory, chronic irritations induce tumors with genetic alterations and rapid proliferative ability. Tumor cells reprogram the metabolism and employ aerobic glycolysis to sustain rapid growth. The host provides both the nutrients and exhaust system to support tumor growth via the tumor microenvironment. Read More

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http://dx.doi.org/10.3892/ijmm.2018.4004DOI Listing
November 2018

MicroRNA-140-5p aggravates hypertension and oxidative stress of atherosclerosis via targeting Nrf2 and Sirt2.

Int J Mol Med 2018 Nov 26. Epub 2018 Nov 26.

Department of General Surgery II, Central Hospital of Luohe, Luohe, Henan 462000, P.R. China.

In the present study, the function of microRNA (miR)‑140‑5p on oxidative stress in mice with atherosclerosis was investigated. A reverse transcription‑quantitative polymerase chain reaction assay was used to determine the expression of miR‑140‑5p. Oxidative stress kits and reactive oxygen species (ROS) kits were used to analyze alterations in oxidative stress and ROS levels. Read More

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http://dx.doi.org/10.3892/ijmm.2018.3996DOI Listing
November 2018

Knockdown of long non-coding RNA HOST2 inhibits the proliferation of triple negative breast cancer via regulation of the let-7b/CDK6 axis.

Int J Mol Med 2018 Nov 26. Epub 2018 Nov 26.

Department of Oncology, Wuhai People's Hospital, Wuhai, Inner Mongolia Autonomous Region 016000, P.R. China.

The upregulation of long non‑coding RNA (lncRNA) human ovarian cancer‑specific transcript 2 (HOST2) has been identified in breast cancer. The present study aimed to investigate whether lncRNA HOST2 regulated the proliferation of triple negative breast cancer (TNBC) cells, and the underlying molecular mechanism. In total, 30 patients with primary TNBC, who were treated at Wuhai People's Hospital (Wuhai, China), were recruited for the present study. Read More

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http://dx.doi.org/10.3892/ijmm.2018.3995DOI Listing
November 2018
1 Read

Attenuation of autophagy flux by 6-shogaol sensitizes human liver cancer cells to TRAIL-induced apoptosis via p53 and ROS.

Int J Mol Med 2018 Nov 21. Epub 2018 Nov 21.

Department of Biochemistry, College of Veterinary Medicine, Chonbuk National University, Iksan, Jeonbuk 54596, Republic of Korea.

Tumor necrosis factor (TNF)‑related apoptosis‑inducing ligand (TRAIL) is a member of the TNF superfamily and is an antitumor drug that induces apoptosis in tumor cells with minimal or no effects on normal cells. Here, it is demonstrated that 6‑shogaol (6‑sho), a bioactive component of ginger, exerted anti‑inflammatory and anticancer properties, attenuated tumor cell propagation and induced TRAIL‑mediated cell death in liver cancer cells. The current study identified a potential pathway by revealing that TRAIL and 6‑sho or chloroquine acted together to trigger reactive oxygen species (ROS) production, to upregulate tumor‑suppressor protein 53 (p53) expression and to change the mitochondrial transmembrane potential (MTP). Read More

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http://www.spandidos-publications.com/10.3892/ijmm.2018.3994
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http://dx.doi.org/10.3892/ijmm.2018.3994DOI Listing
November 2018
4 Reads

Hyaluronic acid-chitosan nanoparticles encoding CrmA attenuate interleukin-1β induced inflammation in synoviocytes in vitro.

Int J Mol Med 2018 Nov 26. Epub 2018 Nov 26.

Department of Orthopedics, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China.

Osteoarthritis (OA) is a common degenerative joint disease characterized by inflammation of synoviocytes and degradation of cartilage. In the present study, hyaluronic acid/chitosan (HA/CS) nanoparticles were used as a vehicle for gene therapy of OA, and the cytokine response modifier A (CrmA) pDNA was proposed as the target gene. The HA/CS/pCrmA nanoparticles were prepared and the characteristics of the nanoparticles were examined. Read More

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http://dx.doi.org/10.3892/ijmm.2018.3997DOI Listing
November 2018

Astragaloside IV ameliorates high glucose‑induced renal tubular epithelial‑mesenchymal transition by blocking mTORC1/p70S6K signaling in HK‑2 cells.

Int J Mol Med 2018 Nov 26. Epub 2018 Nov 26.

Department of Pharmacy, Children's Hospital of Fudan University, Shanghai 201102, P.R. China.

Astragaloside IV (AST) is the major active saponin in Astragalus membranaceus and, reportedly, has a variety of pharmacological activities. However, the potential of AST to ameliorate high glucose‑mediated renal tubular epithelial‑mesenchymal transition (EMT) remains undetermined. The aim of the present research was to explore the effect and mechanism of AST in EMT of renal tubular epithelial cells, as an underlying mechanism of renal fibrosis and a vital feature involved in diabetic nephropathy. Read More

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http://dx.doi.org/10.3892/ijmm.2018.3999DOI Listing
November 2018
1.880 Impact Factor

Rosiglitazone attenuates cell apoptosis through antioxidative and anti-apoptotic pathways in the hippocampi of spontaneously hypertensive rats.

Int J Mol Med 2018 Nov 19. Epub 2018 Nov 19.

Department of Cardiology, The Second Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, Xi'an, Shanxi 710004, P.R. China.

Oxidative stress serves an important role in hypertensive brain damage. Peroxisome proliferator‑activated receptor γ (PPAR‑γ) agonists possess antioxidative and anti‑apoptotic effects. The present study verified the possibility that rosiglitazone serves a neuroprotective role by alleviating oxidative stress and cell apoptosis in the hippocampi of spontaneously hypertensive rats (SHRs). Read More

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http://dx.doi.org/10.3892/ijmm.2018.3991DOI Listing
November 2018

Physiological function of myocilin and its role in the pathogenesis of glaucoma in the trabecular meshwork (Review).

Int J Mol Med 2018 Nov 20. Epub 2018 Nov 20.

Department of General Surgery, Jingjiang People's Hospital, Jingjiang, Jiangsu 214500, P.R. China.

Myocilin is highly expressed in the trabecular meshwork (TM), which plays an important role in the regulation of intraocular pressure (IOP). Myocilin abnormalities may cause dysfunction of the TM, potentially leading to increased IOP. High IOP is a well‑known primary risk factor for glaucoma. Read More

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http://dx.doi.org/10.3892/ijmm.2018.3992DOI Listing
November 2018

Isorhamnetin alleviates lipopolysaccharide-induced inflammatory responses in BV2 microglia by inactivating NF-κB, blocking the TLR4 pathway and reducing ROS generation.

Int J Mol Med 2018 Nov 20. Epub 2018 Nov 20.

Department of Biochemistry, Dongeui University College of Korean Medicine, Busan 47227, Republic of Korea.

Isorhamnetin, which is a flavonoid predominantly found in fruits and leaves of various plants, including Hippophae rhamnoides L. and Oenanthe javanica (Blume) DC, is known to possess various pharmacological effects. However, the anti‑inflammatory potential of isorhamnetin remains poorly studied. Read More

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http://dx.doi.org/10.3892/ijmm.2018.3993DOI Listing
November 2018

In vitro enhancement and functional characterization of neurite outgrowth by undifferentiated adipose-derived stem cells.

Int J Mol Med 2019 Jan 6;43(1):593-602. Epub 2018 Nov 6.

Department of Plastic, Aesthetic, Hand and Reconstructive Surgery, Hannover Medical School, D‑30625 Hannover, Germany.

Adipose‑derived stem cells (ASCs) can easily be obtained and expanded in vitro for use in autologous cell therapy. Via their production of cytokines and neurotrophic factors, transplanted ASCs provide neuroprotection, neovascularization and induction of axonal sprouting. However, the influencing mechanism of undifferentiated ASCs on nerve regeneration is currently only partially understood. Read More

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http://dx.doi.org/10.3892/ijmm.2018.3979DOI Listing
January 2019

Mitochondria-targeted antioxidant therapy for an animal model of PCOS-IR.

Int J Mol Med 2019 Jan 5;43(1):316-324. Epub 2018 Nov 5.

Central Laboratory, Hangzhou First People's Hospital, Zhejiang University, School of Medicine, Hangzhou, Zhejiang 310006, P.R. China.

Polycystic ovary syndrome (PCOS) is a common endocrine disorder with unknown etiology and unsatisfactory clinical treatment. Considering the ethical limitations of studies involving humans, animal models that reflect features of PCOS and insulin resistance (IR) are crucial resources in investigating this syndrome. Our previous study showed that mitochondrial dysfunction resulted from pathogenic mutations of mitochondrial DNA (mtDNA), and that oxidative stress had an active role in the phenotypic manifestation of PCOS‑IR. Read More

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http://dx.doi.org/10.3892/ijmm.2018.3977DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257859PMC
January 2019
1 Read

C1QTNF6 is overexpressed in gastric carcinoma and contributes to the proliferation and migration of gastric carcinoma cells.

Int J Mol Med 2019 Jan 6;43(1):621-629. Epub 2018 Nov 6.

Department of Gastroenterology, Qingdao University Affiliated Qingdao Municipal Hospital, Qingdao, Shandong 266071, P.R. China.

In the present study, proteins differentially expressed between gastric cancer tissue and para‑tumoral normal gastric tissues were screened, and the function of the highly expressed protein C1QTNF6 in gastric carcinoma was investigated. The differential expression of mRNAs extracted from the tumor and adjacent tissues was analyzed using GeneChip assay. An AGS si‑C1QTNF6 cell line was constructed using shRNA‑C1QTNF6 lentivirus. Read More

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http://dx.doi.org/10.3892/ijmm.2018.3978DOI Listing
January 2019
1 Read

Application of metabolomics part II: Focus on fatty acids and their metabolites in healthy adults.

Int J Mol Med 2019 Jan 14;43(1):233-242. Epub 2018 Nov 14.

Laboratory of Toxicology and Forensic Sciences, Medical School, University of Crete, 71003 Heraklion, Greece.

Fatty acids (FAs) play critical roles in health and disease. The detection of FA imbalances through metabolomics can provide an overview of an individual's health status, particularly as regards chronic inflammatory disorders. In this study, we aimed to establish sensitive reference value ranges for targeted plasma FAs in a well‑defined population of healthy adults. Read More

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http://www.spandidos-publications.com/10.3892/ijmm.2018.3989
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http://dx.doi.org/10.3892/ijmm.2018.3989DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257830PMC
January 2019
4 Reads

Proteolysis is the most fundamental property of malignancy and its inhibition may be used therapeutically (Review).

Int J Mol Med 2019 Jan 7;43(1):15-25. Epub 2018 Nov 7.

Urology Research Center, Department of Urology, Health Science Campus, The University of Toledo, Toledo, OH 43614‑2598, USA.

The mortality rates of cancer patients decreased by ~1.5% per year between 2001 and 2015, although the decrease depends on patient sex, ethnic group and type of malignancy. Cancer remains a significant global health problem, requiring a search for novel treatments. Read More

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http://www.spandidos-publications.com/10.3892/ijmm.2018.3983
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http://dx.doi.org/10.3892/ijmm.2018.3983DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257838PMC
January 2019
3 Reads

'Governor vessel-unblocking and mind-regulating' acupuncture therapy ameliorates cognitive dysfunction in a rat model of middle cerebral artery occlusion.

Int J Mol Med 2019 Jan 6;43(1):221-232. Epub 2018 Nov 6.

Department of Rehabilitation, Guangdong Provincial Hospital of Traditional Chinese Medicine Integrated with Western Medicine, Foshan, Guangdong 528200, P.R. China.

Acupuncture is a traditional Chinese medicinal therapy, which is used for the amelioration of cognitive dysfunction. The aim of this study was to investigate the effectiveness and relevancy mechanisms of 'governor vessel‑unblocking and mind‑regulating' acupuncture therapy for cognitive dysfunction in rats with ischemia. For this purpose, we used the middle cerebral artery occlusion (MCAO) method to induce cognitive dysfunction in rats. Read More

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http://dx.doi.org/10.3892/ijmm.2018.3981DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257833PMC
January 2019
5 Reads

Bioinformatics-based study to detect chemical compounds that show potential as treatments for pulmonary thromboembolism.

Int J Mol Med 2019 Jan 12;43(1):276-284. Epub 2018 Nov 12.

Institute of Biomedical Sciences, Fudan University, Shanghai 200032, P.R. China.

The objectives of the present study comprised the recognition of major genes related to pulmonary thromboembolism (PTE) and the evaluation of their functional enrichment levels, in addition to the identification of small chemical molecules that may offer potential for use in PTE treatment. The RNA expression profiling of GSE84738 was obtained from the Gene Expression Omnibus database. Following data preprocessing, the differently expressed genes (DEGs) between the PTE group and the control group were identified using the Linear Models for Microarray package. Read More

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http://www.spandidos-publications.com/10.3892/ijmm.2018.3987
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http://dx.doi.org/10.3892/ijmm.2018.3987DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257851PMC
January 2019
8 Reads

lncRNA MEG3 promotes hepatic insulin resistance by serving as a competing endogenous RNA of miR-214 to regulate ATF4 expression.

Int J Mol Med 2019 Jan 5;43(1):345-357. Epub 2018 Nov 5.

Department of Gerontology, The First Affiliated Hospital of University of Science and Technology of China, Hefei, Anhui 230001, P.R. China.

MicroRNA (miR)‑214 has been demonstrated to suppress gluconeogenesis by targeting activating transcription factor 4 (ATF4), which regulates gluconeogenesis by affecting the transcriptional activity of forkhead box protein O1 (FoxO1). Our previous study revealed that the upregulation of maternally expressed gene 3 (MEG3), a long noncoding RNA, enhanced hepatic insulin resistance via increased FoxO1 expression. The present study aimed to explore whether miR‑214 and ATF4 were involved in the MEG3‑mediated increase of FoxO1 expression. Read More

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http://www.spandidos-publications.com/10.3892/ijmm.2018.3975
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http://dx.doi.org/10.3892/ijmm.2018.3975DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257836PMC
January 2019
3 Reads
1.880 Impact Factor

High-pressure carbon dioxide pneumoperitoneum induces oxidative stress and mitochondria-associated apoptotic pathway in rabbit kidneys with severe hydronephrosis.

Int J Mol Med 2019 Jan 8;43(1):305-315. Epub 2018 Nov 8.

Department of Urology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430000, P.R. China.

The primary aim of the present study was to investigate the potential effect of high‑pressure carbon dioxide (CO2) pneumoperitoneum on kidneys with severe hydronephrosis and to investigate the possible underlying mechanism. A total of 18 rabbits underwent a surgical procedure inducing severe hydronephrosis. Rabbits were then divided at random into three groups (n=6 each) and subjected to intraabdominal pressure of 0, 8 or 18 mmHg, respectively. Read More

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http://dx.doi.org/10.3892/ijmm.2018.3986DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257853PMC
January 2019
1 Read

WITHDRAWN: Mechanism of extracellular‑superoxide dismutase DNA methylation in a hyperhomocysteinemia‑induced atherosclerosis in a mouse model.

Int J Mol Med 2018 11 15. Epub 2018 Nov 15.

Department of Physiology and Pathophysiology, The School of Basic Medical Sciences, Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region 750004, P.R. China.

Ahead of Print article withdrawn by publisher. Read More

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November 2018

miR-181b-5p suppresses starvation-induced cardiomyocyte autophagy by targeting Hspa5.

Int J Mol Med 2019 Jan 12;43(1):143-154. Epub 2018 Nov 12.

Department of Anesthesiology, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215004, P.R. China.

This study aimed to investigate the role of microRNA‑181b‑5p (miR‑181b‑5p) in starvation‑induced cardiomyocyte autophagy by targeting heat shock protein family A member 5 (Hspa5). For this purpose, H9c2 cardiomyocytes and neonatal rat ventricular myocytes (NRVMs) were glucose‑starved in Earle's Balanced Salt Solution (EBSS) for different periods of time (0, 2, 4, 6 and 8 h). RT‑qPCR analysis was performed to examine the expression of miR‑181b‑5p in the different groups. Read More

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http://www.spandidos-publications.com/10.3892/ijmm.2018.3988
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http://dx.doi.org/10.3892/ijmm.2018.3988DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257845PMC
January 2019
6 Reads

Quercetin‑3‑O‑α‑L‑rhamnopyranoside derived from the leaves of Lindera aggregata (Sims) Kosterm. evokes the autophagy‑induced nuclear factor erythroid 2‑related factor 2 antioxidant pathway in human umbilical vein endothelial cells.

Int J Mol Med 2019 Jan 5;43(1):461-474. Epub 2018 Nov 5.

Department of Biomedical Engineering, Zhejiang University, Hangzhou, Zhejiang 310027, P.R. China.

Quercetin‑3‑O‑α‑L‑rhamnopyranoside (QI) is derived from the leaves of Lindera aggregata (Sims) Kosterm. And exhibits multiple biological activities, including an antioxidant activity. However, the detailed molecular mechanism of its antioxidant activity remains unknown. Read More

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http://www.spandidos-publications.com/10.3892/ijmm.2018.3976
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http://dx.doi.org/10.3892/ijmm.2018.3976DOI Listing
January 2019
5 Reads
1.880 Impact Factor

Overexpression of CDCA8 promotes the malignant progression of cutaneous melanoma and leads to poor prognosis.

Int J Mol Med 2019 Jan 7;43(1):404-412. Epub 2018 Nov 7.

Department of Burn and Plastic Surgery, First Affiliated Hospital of Wannan Medical College, Wuhu, Anhui 241001, P.R. China.

Cutaneous melanoma is very aggressive and results in high mortality rates for cancer patients. Determining molecular targets is important for developing novel therapies for cutaneous melanoma. Cell division cycle associated 8 (CDCA8) is a putative oncogene that is upregulated in multiple types of cancer. Read More

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http://www.spandidos-publications.com/10.3892/ijmm.2018.3985
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http://dx.doi.org/10.3892/ijmm.2018.3985DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257860PMC
January 2019
4 Reads

Overexpression of microRNA-183 promotes apoptosis of substantia nigra neurons via the inhibition of OSMR in a mouse model of Parkinson's disease.

Int J Mol Med 2019 Jan 7;43(1):209-220. Epub 2018 Nov 7.

Department of Neurology, The Second Hospital of Dalian Medical University, Dalian, Liaoning 116027, P.R. China.

The present study aimed to investigate the effect of microRNA‑183 (miR‑183) on substantia nigra neurons by targeting oncostatin M receptor (OSMR) in a mouse model of Parkinson's disease (PD). The positive expression rates of OSMR and the apoptosis of substantia nigra neurons were detected by immunohistochemistry and terminal deoxynucleotidyl transferase‑mediated dUTP‑biotin nick end‑labeling, respectively. Substantia nigra neurons in normal and PD mice were cultured in vitro. Read More

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http://dx.doi.org/10.3892/ijmm.2018.3982DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257840PMC
January 2019
3 Reads

Propofol attenuates inflammatory damage on neurons following cerebral infarction by inhibiting excessive activation of microglia.

Int J Mol Med 2019 Jan 5;43(1):452-460. Epub 2018 Nov 5.

Department of Internal Neurology, The Second Affiliated Hospital, Hainan Medical University, Haikou, Hainan 570311, P.R. China.

The overall incidence rate of stroke is increasing worldwide. Inflammatory damage following a stroke is a leading cause for the poor prognosis and high disability rate observed in stroke patients. Microglia are considered to be the main causative agents of inflammatory injury following cerebral infarction, as they secrete various inflammatory cytokines and cytotoxic factors. Read More

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http://www.spandidos-publications.com/10.3892/ijmm.2018.3974
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http://dx.doi.org/10.3892/ijmm.2018.3974DOI Listing
January 2019
4 Reads

Neuroprotective effects of midazolam on focal cerebral ischemia in rats through anti‑apoptotic mechanisms.

Int J Mol Med 2019 Jan 5;43(1):443-451. Epub 2018 Nov 5.

Department of Internal Neurology, The Second Affiliated Hospital of Hainan Medical University, Haikou, Hainan 570311, P.R. China.

Stroke is a cerebrovascular circulatory disorder and its high mortality rate represents a prominent threat to human health. Subsequent apoptosis and cytotoxicity are the main causes underlying the poor prognosis. Midazolam (MDZ) is a benzodiazepine drug that is clinically used during surgical procedures and for the treatment of insomnia, with a potential ability to treat stroke. Read More

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http://www.spandidos-publications.com/10.3892/ijmm.2018.3973
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http://dx.doi.org/10.3892/ijmm.2018.3973DOI Listing
January 2019
6 Reads

Exosome-mediated microRNA-138 and vascular endothelial growth factor in endometriosis through inflammation and apoptosis via the nuclear factor-κB signaling pathway.

Int J Mol Med 2019 Jan 6;43(1):358-370. Epub 2018 Nov 6.

Department of Obstetrics and Gynecology, Liaocheng People's Hospital, Liaocheng, Shandong 252000, P.R. China.

Endometriosis (Ems) is a condition that refers to the ectopic implantation and growth of endometrial tissue outside the uterine cavity. The aim of the present study was to investigate the role of microRNA‑138 (miR‑138) in Ems and the possible underlying mechanism. Flow cytometry was measured CD11b level, cell proliferation was measured using MTT assay and lactate dehydrogenase (LDH) assays was analyzed using LDH activity kits. Read More

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http://www.spandidos-publications.com/10.3892/ijmm.2018.3980
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http://dx.doi.org/10.3892/ijmm.2018.3980DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257842PMC
January 2019
11 Reads

Guanine and nucleotide binding protein 3 promotes odonto/osteogenic differentiation of apical papilla stem cells via JNK and ERK signaling pathways.

Int J Mol Med 2019 Jan 7;43(1):382-392. Epub 2018 Nov 7.

Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China.

Odonto/osteogenic differentiation of stem cells from the apical papilla (SCAPs) is a key process in tooth root formation and development. However, the molecular mechanisms underlying this process remain largely unknown. In the present study, it was identified that guanine and nucleotide binding protein 3 (GNAI3) was at least in part responsible for the odonto/osteogenic differentiation of SCAPs. Read More

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http://www.spandidos-publications.com/10.3892/ijmm.2018.3984
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http://dx.doi.org/10.3892/ijmm.2018.3984DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257834PMC
January 2019
5 Reads

Bone morphogenetic protein 2 alleviated intervertebral disc degeneration through mediating the degradation of ECM and apoptosis of nucleus pulposus cells via the PI3K/Akt pathway.

Int J Mol Med 2019 Jan 2;43(1):583-592. Epub 2018 Nov 2.

Department of Spinal Surgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P.R. China.

The present study aimed to explore the underlying mechanisms of bone morphogenetic protein 2 (BMP2) in alleviating intervertebral disc degeneration (IDD). A rat puncture IDD model was constructed, and the rats were randomly divided into six groups: Control; IDD (model); IDD+PBS [containing 1010 adeno‑associated virus serotype 2 (AAV)]; and IDD + AAV2‑BMP2 (106, 108 and 1010). IL‑1β was used to treat primary nucleus pulposus (NP) cells to mimic IDD in vitro. Read More

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http://www.spandidos-publications.com/10.3892/ijmm.2018.3972
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http://dx.doi.org/10.3892/ijmm.2018.3972DOI Listing
January 2019
2 Reads

Epigenetic mechanisms and implications in tendon inflammation (Review).

Int J Mol Med 2019 Jan 29;43(1):3-14. Epub 2018 Oct 29.

Department of Clinical and Translational Science, Creighton University School of Medicine, Omaha, NE 68178, USA.

Cellular inflammation is not just an immediate response following pathogenic infections or resulting from damage due to injury, it is also associated with normal physiological functions, including wound healing and tissue repair. The existence of such a definitive role in normal physiology and in disease pathology indicates the presence of a regulatory mechanism that is tightly controlled in normal cells. A tight control over gene expression is associated with regulatory mechanisms in the cells, which can be either inducible or epigenetic. Read More

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http://www.spandidos-publications.com/10.3892/ijmm.2018.3961
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http://dx.doi.org/10.3892/ijmm.2018.3961DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257858PMC
January 2019
1 Read