6,726 results match your criteria International journal of molecular medicine[Journal]


MicroRNA‑223 attenuates LPS‑induced inflammation in an acute lung injury model via the NLRP3 inflammasome and TLR4/NF‑κB signaling pathway via RHOB.

Int J Mol Med 2019 Mar 23;43(3):1467-1477. Epub 2019 Jan 23.

Department of Anesthesiology, Liaocheng People's Hospital, Liaocheng, Shandong 252000, P.R. China.

Acute lung injury (ALI) and the more severe acute respiratory distress syndrome are common and complex inflammatory lung diseases. MicroRNAs (miRs) have emerged as novel gene regulatory molecules, serving a crucial role in a variety of complex diseases, including ALI. In the present study, the anti‑inflammatory action of miR‑223 on inflammation in ALI was demonstrated and the possible mechanism was further examined. Read More

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http://www.spandidos-publications.com/10.3892/ijmm.2019.4075
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http://dx.doi.org/10.3892/ijmm.2019.4075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365085PMC
March 2019
3 Reads

Rapamycin‑induced miR‑30a downregulation inhibits senescence of VSMCs by targeting Beclin1.

Int J Mol Med 2019 Mar 23;43(3):1311-1320. Epub 2019 Jan 23.

Department of Geriatrics, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, P.R. China.

Vascular senescence is considered to be an independent risk factor for cardiovascular diseases. The present study aimed to investigate the effects of rapamycin on miR‑30a and its relationship with autophagy and senescence in vascular smooth muscle cells (VSMCs). Young and aging VSMCs were treated with rapamycin or transfected with miR‑30a mimics. Read More

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http://dx.doi.org/10.3892/ijmm.2019.4074DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365076PMC

Protective effect of a hydrogen sulfide donor on balloon injury-induced restenosis via the Nrf2/HIF-1α signaling pathway.

Int J Mol Med 2019 Mar 23;43(3):1299-1310. Epub 2019 Jan 23.

Department of Vascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China.

Restenosis is liable to occur following treatment with endovascular interventional therapy. Increasing evidence indicates that hydrogen sulfide (H2S) exhibits numerous physiological properties, including antioxidative and cardioprotective disease properties. Thus, the present study aimed to investigate the anti‑restenosis effects of H2S and its protective mechanisms. Read More

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http://dx.doi.org/10.3892/ijmm.2019.4076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365080PMC
March 2019
1 Read

MicroRNA-101 inhibits autophagy to alleviate liver ischemia/reperfusion injury via regulating the mTOR signaling pathway.

Int J Mol Med 2019 Mar 24;43(3):1331-1342. Epub 2019 Jan 24.

First Central Clinical College, Tianjin Medical University, Tianjin 300070, P.R. China.

Liver ischemia/reperfusion injury (LIRI) is a common complication of liver surgery, and affects liver function post‑transplantation. However, the precise mechanism underlying LIRI has not yet been completely elucidated. Previous studies have demonstrated the involvement of a number of microRNAs (miRNAs/miRs) in liver pathophysiology. Read More

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http://dx.doi.org/10.3892/ijmm.2019.4077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365072PMC

miR‑335 promotes stress granule formation to inhibit apoptosis by targeting ROCK2 in acute ischemic stroke.

Int J Mol Med 2019 Mar 22;43(3):1452-1466. Epub 2019 Jan 22.

Department of Anatomy, The Research Center of Basic Integrative Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510006, P.R. China.

Under harmful environmental conditions, stress granules (SGs), macromolecular aggregates that are associated with cell survival and death, are produced in the eukaryotic cytoplasm. However, whether and how microRNAs (miRNAs/miRs) modulate SG formation induced by acute ischemic stroke has not been investigated. In the present study, a rat model of middle cerebral artery occlusion (MCAO) was utilized and miRNA array profiling and reverse transcription‑quantitative polymerase chain reaction were performed. Read More

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http://www.spandidos-publications.com/10.3892/ijmm.2019.4073
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http://dx.doi.org/10.3892/ijmm.2019.4073DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365079PMC
March 2019
2 Reads

Anti‑inflammatory effects of 6‑formyl umbelliferone via the NF‑κB and ERK/MAPK pathway on LPS‑stimulated RAW 264.7 cells.

Int J Mol Med 2019 Jan 25. Epub 2019 Jan 25.

Department of Microbiology, College of Natural Sciences, Pukyong National University, Busan 48513, Republic of Korea.

Inhibition of over‑activated inflammation has been demonstrated as one of the most efficient strategies for treating inflammatory diseases. In the present study, 6‑formyl umbelliferone (6FU) was used to evaluate its anti‑inflammatory effects on lipopolysaccharide (LPS)‑stimulated RAW 264.7 macrophages. Read More

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http://dx.doi.org/10.3892/ijmm.2019.4078DOI Listing
January 2019

Bioinformatic analysis of next‑generation sequencing data to identify dysregulated genes in fibroblasts of idiopathic pulmonary fibrosis.

Int J Mol Med 2019 Jan 31. Epub 2019 Jan 31.

Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan, R.O.C.

Idiopathic pulmonary fibrosis (IPF) is a lethal fibrotic lung disease with an increasing global burden. It is hypothesized that fibroblasts have a number of functions that may affect the development and progression of IPF. However, the present understanding of cellular and molecular mechanisms associated with fibroblasts in IPF remains limited. Read More

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http://dx.doi.org/10.3892/ijmm.2019.4086DOI Listing
January 2019
1 Read

NR2F2 loss‑of‑function mutation is responsible for congenital bicuspid aortic valve.

Int J Mol Med 2019 Jan 31. Epub 2019 Jan 31.

Department of Cardiology, The Fifth People's Hospital of Shanghai, Fudan University, Shanghai 200240, P.R. China.

Congenital bicuspid aortic valve (BAV) represents the most common type of cardiac birth defect affecting 0.4‑2% of the general population, and accounts for a markedly increased incidence of life‑threatening complications, including valvulopathy and aortopathy. Accumulating evidence has demonstrated the genetic basis of BAV. Read More

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http://dx.doi.org/10.3892/ijmm.2019.4087DOI Listing
January 2019
2 Reads

MicroRNA‑199a‑5p functions as a tumor suppressor in oral squamous cell carcinoma via targeting the IKKβ/NF‑κB signaling pathway.

Int J Mol Med 2019 Jan 29. Epub 2019 Jan 29.

Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Xinxiang Medical University, Weihui, Henan 453100, P.R. China.

MicroRNAs (miRNAs) have been shown to have a significant role in the progression of several types of cancer, including oral squamous cell carcinoma (OSCC). However, the biological function and regulatory mechanisms of miRNAs in OSCC remain to be fully elucidated. The aim of the present study was to investigate the role of miRNAs in OSCC and the relevant mechanism. Read More

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http://dx.doi.org/10.3892/ijmm.2019.4083DOI Listing
January 2019

Salidroside protects PC-12 cells against amyloid β-induced apoptosis by activation of the ERK1/2 and AKT signaling pathways.

Int J Mol Med 2019 Feb 1. Epub 2019 Feb 1.

Department of Psychiatry, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang 310014, P.R. China.

Alzheimer's disease (AD) is one of the most frequent diseases in elderly people and causes high mortality. Its incidence is increasing annually and no effective therapeutic treatment currently exists. In the present study, salidroside, a major active ingredient of Rhodiola rosea, was able to protect PC‑12 cells from the toxicity and apoptosis induced by AD inducer amyloid (A)β1‑42. Read More

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http://dx.doi.org/10.3892/ijmm.2019.4088DOI Listing
February 2019
1 Read

miR-183 modulated cell proliferation and apoptosis in ovarian cancer through the TGF-β/Smad4 signaling pathway.

Int J Mol Med 2019 Jan 29. Epub 2019 Jan 29.

Department of Gynecological Oncology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430071, P.R. China.

An increasing body of evidence has revealed that the aberrant expression of microRNAs (miRNAs/miRs) is involved in the development and progression of ovarian cancer (OC). miR‑183 has been demonstrated to act as a tumor suppressor and oncogene in various types of human cancers. However, the biological role of miR‑183 in OC still remains unclear. Read More

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http://dx.doi.org/10.3892/ijmm.2019.4082DOI Listing
January 2019
1 Read

Inhibition of acid‑sensing ion channel 1a attenuates acid‑induced activation of autophagy via a calcium signaling pathway in articular chondrocytes.

Int J Mol Med 2019 Jan 31. Epub 2019 Jan 31.

School of Pharmacy, Anhui Medical University, Hefei, Anhui 230032, P.R. China.

Acid‑sensing ion channel 1a (ASIC1a), member of the degenerin/epithelial sodium channel protein superfamily, serves a critical role in various physiological and pathological processes. The aim of the present study was to examine the role of ASIC1a in the autophagy of rat articular chondrocytes. Autophagy was induced by acidic stimulation in rat articular chondrocytes and the extent of autophagy was evaluated via the expression levels of microtubule‑associated protein 1 light chain 3II, Beclin1 and uncoordinated‑51 like kinase1. Read More

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http://dx.doi.org/10.3892/ijmm.2019.4085DOI Listing
January 2019
1 Read

Metformin prevents nephrolithiasis formation by inhibiting the expression of OPN and MCP-1 in vitro and in vivo.

Int J Mol Med 2019 Jan 30. Epub 2019 Jan 30.

Department of Urology, Tianjin Institute of Urology, The Second Hospital of Tianjin Medical University, Hexi, Tianjin 300211, P.R. China.

Treatment targeting osteopontin (OPN) and monocyte chemoattractant protein 1 (MCP‑1) has been recognized as a novel approach in renal crystal formation. The present study was designed to investigate the suppressive effects of metformin on nephrolithiasis formation and its potential mechanism. The cytotoxicity of metformin on MDCK and HK‑2 cells was determined using a Cell Counting Kit‑8 assay in vitro. Read More

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http://dx.doi.org/10.3892/ijmm.2019.4084DOI Listing
January 2019
1 Read
1.880 Impact Factor

Nrdp1 is involved in hippocampus apoptosis in cardiopulmonary bypass-induced cognitive dysfunction via the regulation of ErbB3 protein levels.

Int J Mol Med 2019 Jan 28. Epub 2019 Jan 28.

Department of Anesthesiology, The First Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, P.R. China.

The cardiopulmonary bypass (CPB) is an important risk factor for the development of postoperative cognitive dysfunction (POCD). The pathological mechanism of the neuro‑modulation receptor degradation protein ring finger protein 41 (Nrdp1) in CPB‑induced cognitive dysfunction remains unclear. In the present study, aged Sprague‑Dawley male rats and CPB treatment were selected to duplicate the POCD model. Read More

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http://www.spandidos-publications.com/10.3892/ijmm.2019.4080
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http://dx.doi.org/10.3892/ijmm.2019.4080DOI Listing
January 2019
2 Reads

Nucleolin promotes Ang II‑induced phenotypic transformation of vascular smooth muscle cells via interaction with tropoelastin mRNA.

Int J Mol Med 2019 Feb 4. Epub 2019 Feb 4.

Department of Cardiology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China.

The current study aimed to clarify the role of nucleolin in the phenotypic transformation of vascular smooth muscle cells (VSMCs) and to preliminarily explore its underlying mechanism. The spatial and temporal expression patterns of nucleolin, and the effects of angiotensin II (Ang II) on the expression of VSMC phenotypic transformation markers, α‑smooth muscle‑actin, calponin, smooth muscle protein 22α and osteopontin were investigated. The effects of nucleolin on VSMC phenotypic transformation and the expression of phenotypic transformation‑associated genes, tropoelastin, epiregulin and fibroblast growth factor 2 (b‑FGF), were determined. Read More

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http://dx.doi.org/10.3892/ijmm.2019.4090DOI Listing
February 2019

Beclin1 inhibition enhances paclitaxel‑mediated cytotoxicity in breast cancer in vitro and in vivo.

Int J Mol Med 2019 Feb 1. Epub 2019 Feb 1.

Central Laboratory, Navy General Hospital, Beijing 100048, P.R. China.

Beclin1, a key regulator of autophagy, has been demonstrated to be associated with cancer cell resistance to chemotherapy. Paclitaxel is a conventional chemotherapeutic drug used in the clinical treatment of breast cancer. However, the function and mechanism of Beclin1 in paclitaxel‑mediated cytotoxicity in breast cancer are not well defined. Read More

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http://dx.doi.org/10.3892/ijmm.2019.4089DOI Listing
February 2019
1 Read

[Corrigendum] Methanol extract of Guettarda speciosa Linn. inhibits the production of inflammatory mediators through the inactivation of Syk and JNK in macrophages.

Int J Mol Med 2019 Jan 28. Epub 2019 Jan 28.

Laboratory of Molecular Pharmacological Cell Biology, College of Pharmacy, Chung‑Ang University, Seoul 06974, Republic of Korea.

After the acceptance of the article and during the pre‑publication stages, the author listed second on the paper, Young‑Chang Cho, moved to a new affiliation (College of Pharmacy, Chonnam National University, Gwangju 61186, Korea). Therefore, the published paper should also have included details of the new affiliation as a 'Present address'. The author and affiliation information should have been shown as follows: HIEN THI THU LE1*, YOUNG‑CHANG CHO1,2* and SAYEON CHO1. Read More

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http://dx.doi.org/10.3892/ijmm.2019.4079DOI Listing
January 2019

miR-135 regulated breast cancer proliferation and epithelial-mesenchymal transition acts by the Wnt/β-catenin signaling pathway.

Int J Mol Med 2019 Jan 29. Epub 2019 Jan 29.

Department of Gynecological Oncology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430071, P.R. China.

Breast cancer (BC) is the most common cancer in women around the world. microRNAs (miRNAs/miRs) have been proved to be associated with the development and progression of breast cancer. In the present study, to elucidate the effects of dysregulated miR‑135 on cells and underlying mechanisms in BC, in vitro and in vivo experiments were conducted. Read More

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http://dx.doi.org/10.3892/ijmm.2019.4081DOI Listing
January 2019
1 Read

SIRT1 mediates the role of RNA-binding protein QKI 5 in the synthesis of triglycerides in non-alcoholic fatty liver disease mice via the PPARα/FoxO1 signaling pathway.

Int J Mol Med 2019 Mar 10;43(3):1271-1280. Epub 2019 Jan 10.

Department of Oncology, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, P.R. China.

Non‑alcoholic fatty liver disease (NAFLD) is the consequence of insulin resistance, fatty acid accumulation, oxidative stress and lipotoxicity. The present study aimed to elucidate the effect of Quaking 5 (QKI 5) as mediated by Sirtuin 1 (SIRT1) on triglyceride (TG) synthesis in the liver of an NAFLD mouse model. A high‑fat diet‑induced NAFLD model was established in mice, and mouse hepatocytes were isolated to characterize the effects of QKI 5 mediated by SIRT1 on TG synthesis in the liver. Read More

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http://dx.doi.org/10.3892/ijmm.2019.4059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365049PMC
March 2019
2 Reads

Fibroblast growth factor-21 alleviates hypoxia/reoxygenation injury in H9c2 cardiomyocytes by promoting autophagic flux.

Int J Mol Med 2019 Mar 21;43(3):1321-1330. Epub 2019 Jan 21.

Key Laboratory for Arteriosclerology of Hunan Province, Institute of Cardiovascular Disease, University of South China, Hengyang, Hunan 421001, P.R. China.

Fibroblast growth factor (FGF)‑21, a member of the family of FGFs, exhibits protective effects against myocardial ischemia and ischemia/reperfusion injury; it is also an enhancer of autophagy. However, the mechanisms underlying the protective role of FGF‑21 against cardiomyocyte hypoxia/reoxygenation (H/R) injury remain unclear. The present study aimed to investigate the effect of FGF‑21 on H9c2 cardiomyocyte injury induced by H/R and the mechanism associated with changes in autophagy. Read More

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http://dx.doi.org/10.3892/ijmm.2019.4071DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365083PMC
March 2019
1 Read

Adiponectin protects against uric acid‑induced renal tubular epithelial inflammatory responses via the AdipoR1/AMPK signaling pathway.

Int J Mol Med 2019 Mar 21;43(3):1542-1552. Epub 2019 Jan 21.

Department of Nephrology, Huadong Hospital Affiliated with Fudan University, Shanghai 200040, P.R. China.

Adiponectin (APN) exerts anti‑inflammatory effects in various cells. Uric acid (UA) induces inflammation in proximal renal tubular epithelial cells (PTECs). It remains unknown whether APN protects against UA‑induced inflammation. Read More

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http://dx.doi.org/10.3892/ijmm.2019.4072DOI Listing
March 2019
1 Read

miR‑16‑2‑3p inhibits cell proliferation and migration and induces apoptosis by targeting PDPK1 in maxillary primordium mesenchymal cells.

Int J Mol Med 2019 Mar 21;43(3):1441-1451. Epub 2019 Jan 21.

Department of Burns and Plastic Surgery, Children's Hospital of Nanjing Medical University, Nanjing, Jiangsu 210008, P.R. China.

MicroRNAs (miRNAs) post‑transcriptionally regulate gene expression by targeting the 3' untranslated region (UTR) of target genes, and serve diverse roles in cell proliferation, differentiation and apoptosis. However, the association between miR‑16‑2‑3p and 3‑phosphoinositide‑dependent protein kinase‑1 (PDPK1) in nonsyndromic cleft lip (NSCL) remains unclear. In the present study, a luciferase activity assay indicated that miR‑16‑2‑3p negatively regulated PDPK1 in maxillary primordium mesenchymal cells (MPMCs). Read More

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http://dx.doi.org/10.3892/ijmm.2019.4070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365086PMC
March 2019
1 Read

Canis familiaris allergen Can f 7: Expression, purification and analysis of B cell epitopes in Chinese children with dog allergies.

Int J Mol Med 2019 Mar 15;43(3):1531-1541. Epub 2019 Jan 15.

Research Division of Clinical Pharmacology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China.

Dogs are a major source of indoor allergens. However, the prevalence of dog allergies in China remains unclear, especially in children. In the present study, Can f 7, a canine allergen belonging to the Niemann pick type C2 protein family, was selected to study its sensitization rate in Chinese children with dog allergies. Read More

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http://dx.doi.org/10.3892/ijmm.2019.4065DOI Listing
March 2019
2 Reads
1.880 Impact Factor

Recombinant fimbriae protein of Porphyromonas gingivalis induces an inflammatory response via the TLR4/NF‑κB signaling pathway in human peripheral blood mononuclear cells.

Int J Mol Med 2019 Mar 21;43(3):1430-1440. Epub 2019 Jan 21.

Department of Pathogeny Biology, Jinzhou Medical University, Jinzhou, Liaoning 121000, P.R. China.

Porphyromonas gingivalis (P. gingivalis) is a periodontal pathogen that may accumulate with other organisms in subgingival plaque biofilms and is associated with periodontal disease. P. Read More

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http://dx.doi.org/10.3892/ijmm.2019.4069DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365089PMC
March 2019
1 Read
1.880 Impact Factor

Identification of antiproliferative emodin analogues as inhibitors of epidermal growth factor receptor in cancer.

Int J Mol Med 2019 Mar 16;43(3):1281-1288. Epub 2019 Jan 16.

School of Pharmacy, China Medical University, Taichung 40402, Taiwan, R.O.C.

A series of emodin analogues have been demonstrated to exhibit potent antiproliferative activity in three human epidermal growth factor receptor 2 (HER2)‑overexpressing cell lines. However, in docking simulations, not all of these emodin analogues docked into the HER2 protein binding site. As the epidermal growth factor receptor (EFGR) and HER2 proteins are members of the ErbB family, the present study aimed to determine whether these anthraquinone derivatives exhibit potent antitumour bioactivity due to their inhibition of EGFR protein. Read More

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http://dx.doi.org/10.3892/ijmm.2019.4066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365047PMC
March 2019
1 Read

Biliverdin administration regulates the microRNA-mRNA expressional network associated with neuroprotection in cerebral ischemia reperfusion injury in rats.

Int J Mol Med 2019 Mar 14;43(3):1356-1372. Epub 2019 Jan 14.

Department of Anesthesiology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650000, P.R. China.

Inflammatory response has an important role in the outcome of cerebral ischemia reperfusion injury (CIR). Biliverdin (BV) administration can relieve CIR in rats, but the mechanism remains unknown. The aim of the present study was to explore the expressional network of microRNA (miRNA)‑mRNA in CIR rats following BV administration. Read More

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http://dx.doi.org/10.3892/ijmm.2019.4064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365090PMC
March 2019
1 Read

Non‑canonical Wnt signaling contributes to ventilator‑induced lung injury through upregulation of WISP1 expression.

Int J Mol Med 2019 Mar 17;43(3):1217-1228. Epub 2019 Jan 17.

Department of Anesthesiology and Perioperative Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.

Mechanical ventilation may cause ventilator‑induced lung injury (VILI). Canonical Wnt signaling has been reported to serve an important role in the pathogenesis of VILI. Bioinformatics analysis revealed that canonical and non‑canonical Wnt signaling pathways were activated in VILI. Read More

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http://dx.doi.org/10.3892/ijmm.2019.4067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365043PMC
March 2019
2 Reads

MicroRNA‑9‑5p downregulates Klf4 and influences the progression of hepatocellular carcinoma via the AKT signaling pathway.

Int J Mol Med 2019 Mar 14;43(3):1417-1429. Epub 2019 Jan 14.

Department of Oncology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, P.R. China.

Krüppel‑like factor 4 (Klf4) is a transcriptional factor involved in the progression of hepatocellular carcinoma (HCC). However, the underlying regulatory mechanisms associated with the Klf4 gene as a tumor suppressor in HCC remain unclear. microRNAs (miRNAs or miRs) are a series of small non‑coding RNAs that serve a vital role in regulating gene expression via their influence on protein translation and the associated degradation of mRNA. Read More

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http://dx.doi.org/10.3892/ijmm.2019.4062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365078PMC
March 2019
1 Read

Laminar shear stress alters endothelial KCa2.3 expression in H9c2 cells partially via regulating the PI3K/Akt/p300 axis.

Int J Mol Med 2019 Mar 14;43(3):1289-1298. Epub 2019 Jan 14.

Department of Cardiovascular Surgery, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650021, P.R. China.

In cardiac tissues, myoblast atrial myocytes continue to be exposed to mechanical forces including shear stress. However, little is known about the effects of shear stress on atrial myocytes, particularly on ion channel function, in association with disease. The present study demonstrated that the Ca2+‑activated K+ channel (KCa)2. Read More

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http://dx.doi.org/10.3892/ijmm.2019.4063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365081PMC
March 2019
2 Reads

miR‑122 and miR‑199 synergistically promote autophagy in oral lichen planus by targeting the Akt/mTOR pathway.

Int J Mol Med 2019 Mar 21;43(3):1373-1381. Epub 2019 Jan 21.

Department of Geriatrics, Ningbo No. 2 Hospital, Ningbo, Zhejiang 315010, P.R. China.

The aim of the present study was to characterize the roles of two microRNAs (miRNAs), miR‑122 and miR‑199, in oral lichen planus (OLP). miRNA microarray analysis was performed to detect potential miRNAs involved in OLP, while in‑silicon analysis, reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR), western blot and immunohistochemistry (IHC) analyses were utilized to explore the molecular mechanisms underlying the roles of miR‑199 and miR‑122 in OLP. The results from the microarray and RT‑qPCR analyses demonstrated that the expression levels of miR‑122 and miR‑199 were significantly decreased in the peripheral blood mononuclear cells (PBMCs) collected from the OLP group compared with the control group. Read More

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http://dx.doi.org/10.3892/ijmm.2019.4068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365087PMC
March 2019
1 Read

Caspase recruitment domains for protein interactions in cellular signaling (Review).

Authors:
Hyun Ho Park

Int J Mol Med 2019 Mar 11;43(3):1119-1127. Epub 2019 Jan 11.

Department of Pharmacy, College of Pharmacy, Chung‑Ang University, Seoul 06974, Republic of Korea.

The caspase recruitment domain (CARD), a well‑known protein interaction module, belongs to the death domain (DD) superfamily, which includes DDs, death effector domains, and pyrin domains. The DD superfamily mediates the protein interactions necessary for apoptosis and immune cell signaling pathways. Among these domains, the CARD has been studied extensively as it mediates important cellular signaling events that are associated with various human diseases including cancer, neuro‑degenerative diseases and immune disorders. Read More

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http://dx.doi.org/10.3892/ijmm.2019.4060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365033PMC
March 2019
1 Read

Synergistic anticancer effect of acteoside and temozolomide-based glioblastoma chemotherapy.

Int J Mol Med 2019 Mar 11;43(3):1478-1486. Epub 2019 Jan 11.

Department of Medical Science, School of Medicine, Chungnam National University, Daejeon 35015, Republic of Korea.

Temozolomide (TMZ) is an alkylating agent commonly used as a first‑line treatment for high‑grade glioblastoma. However, TMZ has short half‑life and frequently induces tumor resistance, which can limit its therapeutic efficiency. In the present study, it was hypothesized that combined treatment with TMZ and acteoside has synergistic effects in glioblastoma therapy. Read More

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http://www.spandidos-publications.com/10.3892/ijmm.2019.4061
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http://dx.doi.org/10.3892/ijmm.2019.4061DOI Listing
March 2019
7 Reads

Pristimerin enhances the effect of cisplatin by inhibiting the miR‑23a/Akt/GSK3β signaling pathway and suppressing autophagy in lung cancer cells.

Int J Mol Med 2019 Mar 10;43(3):1382-1394. Epub 2019 Jan 10.

Department of Radiation Oncology, The First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China.

Lung cancer is a common type of cancer with a high mortality rate in China. Cisplatin (Cis) is one of the most effective broad‑spectrum chemotherapeutic drugs for the treatment of advanced lung cancer. However, Cis resistance remains an obstacle in the treatment of advanced lung cancer. Read More

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http://dx.doi.org/10.3892/ijmm.2019.4057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365073PMC
March 2019
1 Read

Protective roles of isoastilbin against Alzheimer's disease via Nrf2‑mediated antioxidation and anti‑apoptosis.

Int J Mol Med 2019 Mar 10;43(3):1406-1416. Epub 2019 Jan 10.

Department of Anesthesiology, Hospital of Stomatology, Jilin University, Changchun, Jilin 130021, P.R. China.

By analyzing the L‑glutamic acid (L‑Glu)‑induced apoptosis of PC12 cells and an AlCl3 combined with D‑galactose (D‑gal)‑developed Alzheimer's disease (AD) mouse model, the protective effects of isoastilbin (IAB) against AD were systematically investigated in the present study. Pre‑incubation with IAB for 3 h prior to treatment with 25 mM L‑Glu decreased cell viability and inhibited apoptosis, suppressed the accumulation of intracellular reactive oxygen species, and restored mitochondrial membrane potential in PC12 cells induced by L‑Glu. In mice with AD, the reduced escape latency time in the water maze test, suppressed chronic movement in the center area of an open field test and enhanced ability to seek hidden food in a Y maze test indicated that abnormal behaviors had improved after 28 days of treatment with IAB. Read More

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http://dx.doi.org/10.3892/ijmm.2019.4058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365075PMC
March 2019
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Differentiation of CD45‑/CD31+ lung side population cells into endothelial and smooth muscle cells in vitro.

Int J Mol Med 2019 Mar 8;43(3):1128-1138. Epub 2019 Jan 8.

Department of Biochemistry and Molecular Biology, College of Basic Medical Sciences, Jinzhou Medical University, Jinzhou, Liaoning 121000, P.R. China.

Side population (SP) cells are a small subpopulation of cells found in many mammalian tissues and organs, identified by their capacity to efflux Hoechst 33342 dye. They are enriched for stem/progenitor cell activity. SP cells isolated from the adult mouse lung can be separated into a CD45+ subset (bone marrow‑derived) and a CD45‑ subset that can be subdivided into CD31‑ and CD31+ subpopulations. Read More

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http://www.spandidos-publications.com/10.3892/ijmm.2019.4053
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http://dx.doi.org/10.3892/ijmm.2019.4053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365051PMC
March 2019
5 Reads

miRNA-20b inhibits cerebral ischemia-induced inflammation through targeting NLRP3.

Int J Mol Med 2019 Mar 31;43(3):1167-1178. Epub 2018 Dec 31.

Department of Neurology, Hebei General Hospital, Shijiazhuang, Hebei 050051, P.R. China.

The present study was designed to investigate the role of microRNA (miRNA)‑20b in the inflammatory response during cerebral ischemia and the underlying mechanism following cerebral ischemia. A reverse transcription quantitative polymerase chain reaction assay was used to measure the expression of miRNA‑20b, and tumor necrosis factor α, interleukin (IL)‑6, IL‑18 and IL‑1β levels were measured using ELISA. In addition, the protein expression levels of NOD‑like receptor pyrin domain containing 3 (NLRP3), caspase‑1, IL‑1β and IL‑18 were determined by western blot analysis. Read More

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http://dx.doi.org/10.3892/ijmm.2018.4043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365032PMC

MicroRNA‑223 promotes osteoblast differentiation of MC3T3‑E1 cells by targeting histone deacetylase 2.

Int J Mol Med 2019 Mar 31;43(3):1513-1521. Epub 2018 Dec 31.

Department of Orthopedics, The Third Affiliated Hospital of Southern Medical University, Guangzhou, Guangdong 510630, P.R. China.

MicroRNAs (miRNAs) have emerged as pivotal regulators in various physiological and pathological processes at the post‑transcriptional level, and may serve important roles in osteogenic differentiation. However, their roles and functions are not fully understood. In the present study, miR‑223‑5p was identified as a modulator of osteoblastic differentiation in MC3T3‑E1 cells. Read More

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http://dx.doi.org/10.3892/ijmm.2018.4042DOI Listing

[Corrigendum] Sequence analysis of the Pre‑S gene in chronic asymptomatic HBV carriers with low‑level HBsAg.

Int J Mol Med 2019 Mar 9;43(3):1553. Epub 2019 Jan 9.

Department of Clinical Laboratory, The 117th Hospital of PLA, Hangzhou, Zhejiang 310013, P.R. China.

After the publication of the article, the authors realize that the grant funding number for the support that they received from Natural Science Foundation of Zhejiang Province appeared incorrectly in the Funding section of the paper: This should have been featured as grant no. LY15H200001 (i.e. Read More

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http://dx.doi.org/10.3892/ijmm.2019.4055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365077PMC

miR‑505 inhibits cell growth and EMT by targeting MAP3K3 through the AKT‑NFκB pathway in NSCLC cells.

Int J Mol Med 2019 Mar 31;43(3):1203-1216. Epub 2018 Dec 31.

Department of Respiration, Qingdao Municipal Hospital, Qingdao, Shandong 266071, P.R. China.

MicroRNAs (miRNAs) are short non‑coding RNAs, which generally regulate gene expression at the post‑transcriptional level. Dysregulation of miRNAs has been reported in numerous cancer types, including lung cancer. In the present study, the role of miR‑505 in non‑small cell lung cancer (NSCLC) cells was investigated. Read More

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http://dx.doi.org/10.3892/ijmm.2018.4041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365022PMC

EGFR inhibitor gefitinib regulates barrier function in human epidermal keratinocytes via the modulation of the expression of claudins.

Int J Mol Med 2019 Mar 31;43(3):1522-1530. Epub 2018 Dec 31.

Department of Dermatology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, P.R. China.

Gefitinib, an epidermal growth factor receptor tyrosine kinase inhibitor, has been frequently used in targeted therapy for lung cancer. However, the widespread use of gefitinib in targeted therapy for patients with lung cancer is hampered by its common skin toxicities. The present study aimed to investigate the mechanisms underlying the skin toxicities of gefitinib. Read More

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http://www.spandidos-publications.com/10.3892/ijmm.2018.4046
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http://dx.doi.org/10.3892/ijmm.2018.4046DOI Listing
March 2019
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Lactobacillus rhamnosus GG treatment improves intestinal permeability and modulates microbiota dysbiosis in an experimental model of sepsis.

Int J Mol Med 2019 Mar 7;43(3):1139-1148. Epub 2019 Jan 7.

Department of Geriatrics, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, P.R. China.

Decrease of 'health‑benefiting' microbes and increase of pathogenic bacteria (a condition termed dysbiosis) in intensive care unit patients is considered to induce or aggravate sepsis (gut‑origin sepsis). Orally administered probiotics have been effective in the prevention of nosocomial infections. However, the mechanisms of probiotic‑induced anti‑infection and anti‑sepsis remain to be explored. Read More

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http://www.spandidos-publications.com/10.3892/ijmm.2019.4050
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http://dx.doi.org/10.3892/ijmm.2019.4050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365041PMC
March 2019
7 Reads

Silica nanoparticles induce cardiomyocyte apoptosis via the mitochondrial pathway in rats following intratracheal instillation.

Int J Mol Med 2019 Mar 31;43(3):1229-1240. Epub 2018 Dec 31.

Department of Toxicology, Shandong Academy of Occupational Health and Occupational Medicine, Shandong Academy of Medical Sciences, Ji'nan, Shandong 250062, P.R. China.

Diseases of the cardiac system caused by silicon dioxide exposure have captured wide public attention. Upon entering the blood circulation, ultrafine particles have the potential to influence cardiomyocytes, leading to myocardial ischemia or even cardiac failure, and the molecular mechanisms remain to be completely elucidated. In this study, the toxicity of ultrafine particles on cardiomyocytes from rats exposed to silica nanoparticles was observed. Read More

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http://dx.doi.org/10.3892/ijmm.2018.4045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365031PMC
March 2019
3 Reads

Characterization of the human mucin 5AC promoter and its regulation by the histone acetyltransferase P300.

Int J Mol Med 2019 Mar 9;43(3):1263-1270. Epub 2019 Jan 9.

Division of Pediatric Pulmonology, Wuxi Children's Hospital Affiliated to Nanjing Medical University, Wuxi, Jiangsu 214023, P.R. China.

Histone acetylation is important in the modification of gene transcription in asthma and is regulated by histone acetyltransferases (HATs). P300 (P300 HAT) is an enzyme that is able to acetylate a wide variety of proteins. The modification of core histones can further regulate gene transcription, cell proliferation and other cell processes. Read More

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http://www.spandidos-publications.com/10.3892/ijmm.2019.4054
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http://dx.doi.org/10.3892/ijmm.2019.4054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365035PMC
March 2019
5 Reads

Gene networking in colistin-induced nephrotoxicity reveals an adverse outcome pathway triggered by proteotoxic stress.

Int J Mol Med 2019 Mar 8;43(3):1343-1355. Epub 2019 Jan 8.

Department of Predictive Toxicology, Korea Institute of Toxicology, Daejeon 34114, Republic of Korea.

Colistin has been widely used for the treatment of infections of multidrug‑resistant Gram‑negative bacteria, despite the fact that it induces serious kidney injury as a side effect. To investigate the mechanism underlying its nephrotoxicity, colistin methanesulfonate sodium (CMS; 25 or 50 mg/kg) was administered via intraperitoneal injection to Sprague‑Dawley rats daily over 7 days. Serum biochemistry and histopathology indicated that nephrotoxicity occurred in the rats administered with CMS. Read More

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http://dx.doi.org/10.3892/ijmm.2019.4052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365082PMC

Mesenchymal stem cells with downregulated Hippo signaling attenuate lung injury in mice with lipopolysaccharide‑induced acute respiratory distress syndrome.

Int J Mol Med 2019 Mar 31;43(3):1241-1252. Epub 2018 Dec 31.

Department of Critical Care Medicine, Wuxi People's Hospital, Nanjing Medical University, Wuxi, Jiangsu 214023, P.R. China.

Mesenchymal stem cell (MSC)‑mediated repair of injured alveolar epithelial cells is a promising potential cure for acute respiratory distress syndrome (ARDS); however, the repairing effect of MSCs is limited by poor homing and differentiation. Our previous study revealed that the inhibition of the Hippo signaling pathway promotes the proliferation, migration and differentiation of MSCs in vitro, leading to the hypothesis that MSCs with downregulated Hippo signaling could further ameliorate lipopolysaccharide (LPS)‑induced ARDS in vivo. In the current study, mouse bone marrow‑derived MSCs (mMSCs) with downregulated Hippo signaling were constructed by shRNA‑mediated knockdown of large tumor suppressor kinase 1 (Lats1) and were intratracheally administered to LPS‑induced mouse models of ARDS. Read More

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http://dx.doi.org/10.3892/ijmm.2018.4047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365074PMC
March 2019
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Study of the cytological features of bone marrow mesenchymal stem cells from patients with neuromyelitis optica.

Int J Mol Med 2019 Mar 9;43(3):1395-1405. Epub 2019 Jan 9.

Department of Neurology, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin 300052, P.R. China.

Neuromyelitis optica (NMO) is a refractory autoimmune inflammatory disease of the central nervous system without an effective cure. Autologous bone marrow‑derived mesenchymal stem cells (BM‑MSCs) are considered to be promising therapeutic agents for this disease due to their potential regenerative, immune regulatory and neurotrophic effects. However, little is known about the cytological features of BM‑MSCs from patients with NMO, which may influence any therapeutic effects. Read More

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http://www.spandidos-publications.com/10.3892/ijmm.2019.4056
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http://dx.doi.org/10.3892/ijmm.2019.4056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365084PMC
March 2019
7 Reads
1.880 Impact Factor

Human ether‑à‑go‑go‑related gene mutation L539fs/47‑hERG leads to cell apoptosis through the endoplasmic reticulum stress pathway.

Int J Mol Med 2019 Mar 2;43(3):1253-1262. Epub 2019 Jan 2.

Department of Cardiovascular Medicine, First Affiliated Hospital of Xi'an Jiaotong University, Institute of Cardiovascular Channelopathy, Key Laboratory of Molecular Cardiology, Xi'an, Shaanxi 710061, P.R. China.

Congenital long QT syndrome (LQTS) is a cardiac channelopathy that often results in fatal arrhythmias. LQTS mutations not only lead to abnormal myocardial electrical activities but are associated with heart contraction abnormalities, cardiomyopathy and congenital heart defects. In vivo and in vitro studies have found that LQTS mutations are associated with cardiomyocyte apoptosis, cardiac developmental disorders and even embryonic mortality. Read More

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http://www.spandidos-publications.com/10.3892/ijmm.2019.4049
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http://dx.doi.org/10.3892/ijmm.2019.4049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365044PMC
March 2019
7 Reads

Antioxidant and cytoprotective effects of Stachys riederi var. japonica ethanol extract on UVA‑irradiated human dermal fibroblasts.

Int J Mol Med 2019 Mar 2;43(3):1497-1504. Epub 2019 Jan 2.

Department of Public Health, Faculty of Food and Health Sciences, Keimyung University, Daegu 42601, Republic of Korea.

Stachys riederi is one of the largest genera in the flowering plant family Lamiaceae. The aqueous extract of Stachys riederi var. japonica is known for its anti‑allergic effect. Read More

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http://dx.doi.org/10.3892/ijmm.2019.4048DOI Listing

MicroRNA-204 inhibits the proliferation, migration and invasion of human lung cancer cells by targeting PCNA-1 and inhibits tumor growth in vivo.

Int J Mol Med 2019 Mar 31;43(3):1149-1156. Epub 2018 Dec 31.

Department of Thoracic Surgery, Shengli Oilfield Central Hospital, Dongying, Shandong 257034, P.R. China.

Lung cancer accounts for ~20% of the total cancer‑associated mortalities worldwide. Lung cancer is often diagnosed at advanced stages and is therefore difficult to treat. The biomarkers for diagnosis of lung cancer are limited and unreliable. Read More

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http://dx.doi.org/10.3892/ijmm.2018.4044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365052PMC

MicroRNA-320a acts as a tumor suppressor in endometrial carcinoma by targeting IGF-1R.

Int J Mol Med 2019 Mar 7;43(3):1505-1512. Epub 2019 Jan 7.

Department of Gynecology and Obstetrics, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong 510630, P.R. China.

Dysregulation of microRNAs (miRs) is implicated in the carcinogenesis of various types of malignant tumor by manipulating cell growth and apoptosis. Abnormal expression of miR‑320a is involved in tumorigenesis of many types of cancer. The potential association of miR‑320a and the possible regulatory mechanisms in endometrial carcinoma is rarely elucidated. Read More

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http://dx.doi.org/10.3892/ijmm.2019.4051DOI Listing
March 2019
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